Association between phase angle, anthropometric measurements, and lipid profile in HCV-infected patients

array:24 ["pii" => "S1807593222020452" "issn" => "18075932" "doi" => "10.6061/clinics/2013(12)13" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "2045" "copyright" => "CLINICS" "copyrightAnyo" => "2013" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2013;68:1555-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222020464" "issn" => "18075932" "doi" => "10.6061/clinics/2013(12)14" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "2046" "copyright" => "CLINICS" "documento" => "simple-article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "err" "cita" => "Clinics. 2013;68:1559-60" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "ERRATA" "titulo" => "ERRATA" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1559" "paginaFinal" => "1560" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020464?idApp=UINPBA00004N" "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020464/v1_202212011241/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222020440" "issn" => "18075932" "doi" => "10.6061/clinics/2013(12)12" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "2044" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2013;68:1548-54" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "BASIC RESEARCH" "titulo" => "Local and remote ischemic preconditioning protect against intestinal ischemic/reperfusion injury after supraceliac aortic clamping" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1548" "paginaFinal" => "1554" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 731 "Ancho" => 722 "Tamanyo" => 49524 ] ] "descripcion" => array:1 [ "en" => "Experimental protocol (A) and main arterial pressure variations during the experiment in the control, ischemia and reperfusion (IR), local ischemic preconditioning (LIPC), and remote ischemic preconditioning (RIPC) groups (B). Data are expressed as the mean ± SE for 7 animals per group. (*) p<0.001: IR, LIPC, and RIPC vs. control, (†) p<0.001: LIPC vs. control." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nilon Erling, Edna Frasson de Souza Montero, Paulina Sannomiya, Luiz Francisco Poli-de-Figueiredo (in memoriam)" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Nilon" "apellidos" => "Erling" "sufijo" => "Junior" ] 1 => array:2 [ "nombre" => "Edna Frasson" "apellidos" => "de Souza Montero" ] 2 => array:2 [ "nombre" => "Paulina" "apellidos" => "Sannomiya" ] 3 => array:2 [ "nombre" => "Luiz Francisco" "apellidos" => "Poli-de-Figueiredo (in memoriam)" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020440?idApp=UINPBA00004N" "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020440/v1_202212011241/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "RAPID COMMUNICATION" "titulo" => "Association between phase angle, anthropometric measurements, and lipid profile in HCV-infected patients" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1555" "paginaFinal" => "1558" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mariana de Souza Dorna, Nara Aline Costa, Erick Prado de Oliveira, Ligia Yukie Sassaki, Fernando Gomes Romeiro, Sergio Alberto Rupp de Paiva, Marcos Ferreira Minicucci, Giovanni Faria Silva" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Mariana" "apellidos" => "de Souza Dorna" "email" => array:1 [ 0 => "mari_dorna@yahoo.com.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Nara Aline" "apellidos" => "Costa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Erick Prado" "apellidos" => "de Oliveira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Ligia Yukie" "apellidos" => "Sassaki" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Fernando Gomes" "apellidos" => "Romeiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "Sergio Alberto Rupp" "apellidos" => "de Paiva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 6 => array:3 [ "nombre" => "Marcos Ferreira" "apellidos" => "Minicucci" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 7 => array:3 [ "nombre" => "Giovanni Faria" "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Department of Internal Medicine, Botucatu/SP, Brazil." "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "School of Medicine, Federal University of Uberlandia, Uberlandia/MG, Brazil." "etiqueta" => "II" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 014 3822-2969" ] ] ] ] "textoCompleto" => "INTRODUCTIONIt is estimated that over 170 million people worldwide have hepatitis C in its chronic form (<a class="elsevierStyleCrossRef" href="#bib1">1</a>). Currently, aside from the established consequence of liver injury, chronic hepatitis C virus (HCV) infection is associated with some metabolic disorders. Several studies have highlighted the association between HCV infection and lipid metabolism; however, the relationship between lipid profile and body composition in HCV carriers is less clear (<a class="elsevierStyleCrossRef" href="#bib2">2</a>–<a class="elsevierStyleCrossRef" href="#bib4">4</a>). Although the importance of nutritional assessment in this population is known, there is not yet a gold standard tool for assessing body composition in these subjects (<a class="elsevierStyleCrossRef" href="#bib5">5</a>).For more than 20 years, bioelectrical impedance analysis (BIA) has been used to assess body composition in several clinical situations. BIA measures the resistance to the movement of an electrical current through the body, allowing for the determination of the fat-free mass and total body water. The body offers two types of resistance to an electrical current, namely, capacitive Xc (reactance) and resistive (simply called resistance) resistance. One measurement of the relationship between capacitance and resistance is the phase angle (PhA), and its association with clinical outcomes has already been shown in different pathological situations (<a class="elsevierStyleCrossRef" href="#bib6">6</a>–<a class="elsevierStyleCrossRef" href="#bib12">12</a>).There are few studies that have evaluated the association between PhA, anthropometric measures, and outcomes in patients with chronic liver disease. Selberg et al. showed that PhA was poorly correlated with disease severity (<a class="elsevierStyleCrossRef" href="#bib6">6</a>). However, in their study, PhA was correlated with muscle mass and strength (<a class="elsevierStyleCrossRef" href="#bib6">6</a>). In addition, Kahraman et al. evaluated 37 consecutive patients with HCV infection and showed that PhA reduction was associated with increased side effects following pegylated interferon-α and ribavirin treatment (<a class="elsevierStyleCrossRef" href="#bib12">12</a>).Although BIA is non-invasive, easy-to-use, portable, and inexpensive, this device is not available at all centers. Thus, in this scenario, anthropometric measures are one method for evaluating body composition (<a class="elsevierStyleCrossRef" href="#bib5">5</a>). Despite the association between PhA and anthropometric data, chronically infected HCV patients have not yet been evaluated.Therefore, the present study aimed to investigate the associations between PhA, anthropometric measures, and lipid profile in patients chronically infected with HCV.MATERIALS AND METHODSSubjectsThe present study was approved by the ethics committee of our institution, and written informed consent was obtained from all subjects. All patients chronically infected with HCV who underwent treatment at the hepatitis C outpatient unit of our hospital from April 2010 to May 2011 were prospectively evaluated. The inclusion criteria were naïve patients or lack of treatment with pegylated interferon and ribavirin for at least 1 year, completion of liver biopsy, and clinical diagnosis of liver cirrhosis. The exclusion criteria were liver cirrhosis with ascites, hepatitis B virus infection, HIV infection, chronic kidney disease, heart failure, and pregnancy. Bioelectrical impedance analysis and anthropometric measurements were performed during the first hospital visit. The lipid profile was considered in cases where it had been measured up to three months prior to the evaluation.Assessment of Body CompositionBody height and weight were measured and used to calculate the body mass index (BMI) (<a class="elsevierStyleCrossRef" href="#bib13">13</a>). Mid-arm circumference (MAC) was measured using a measuring tape, as previously described (<a class="elsevierStyleCrossRef" href="#bib14">14</a>). Triceps skinfold (TSF) was measured according to the standardization of Harrison et al. (<a class="elsevierStyleCrossRef" href="#bib15">15</a>). Mid-arm muscle circumference (MAMC) and arm muscle area (AMA) were obtained from the following respective formulas: MAMC = MAC-(π x TSF) and MAMC = MAC-πx(TSF/10) (<a class="elsevierStyleCrossRef" href="#bib16">16</a>). All measurements were performed by the same researcher.Bioelectrical Impedance AnalysisBIA was conducted using a tetrapolar single-frequency apparatus (Biodynamic-450, Biodynamics Corporation, USA) that was applied to the skin using adhesive electrodes with the subject lying supine. PhA derived from the BIA was determined as previously described (<a class="elsevierStyleCrossRef" href="#bib17">17</a>), and its values were calculated as follows: PhA = (arc tangent reactance/resistance * (180°/π)).Lipid Profile DataTotal cholesterol (TC), HDL-cholesterol (HDL), and triglycerides (TG) were measured using a dry-chemistry method. LDL-cholesterol (LDL) was calculated by the Friedwald formula.Statistical AnalysisData are expressed as the mean ± SD or the median (including the lower and upper quartiles). The Spearman correlation was employed to evaluate the association between continuous variables. Multiple linear regressions were used for PhA prediction and adjusted for gender and age. Data analysis was performed using Sigma Stat 3.5 for Windows (Systat Software, Inc., San Jose, CA, USA). P values lower than 0.05 were considered statistically significant.RESULTSOf the 160 consecutive patients initially evaluated, 25 were excluded (10 had incomplete data, 4 had not undergone liver biopsy, 8 had ascites, 1 was physically disabled, 1 had chronic kidney disease and 1 had heart failure). Thus, a total of 135 patients with a mean age of 49.8±11.4 y were assessed. Demographic, anthropometric, and laboratory data are listed in <a class="elsevierStyleCrossRef" href="#t1-cln_68p1555">Table 1</a>. Of the included patients, 60% were male. The PhA and BMI means were 6.5±0.8° and 26.5±4.8 kg/m2, respectively.<elsevierMultimedia ident="t1-cln_68p1555"></elsevierMultimedia>With regard to anthropometric variables, MAC, MAMC, and AMA presented a positive correlation with PhA. In contrast, when analyzing the lipid profile, only HDL was inversely correlated with PhA.However, in multiple regression models adjusted for age and gender, only MAC (p = 0.005), MAMC (p = 0.003), and AMA (p = 0.001) were associated with PhA in HCV-infected patients (<a class="elsevierStyleCrossRef" href="#t2-cln_68p1555">Table 2</a>).<elsevierMultimedia ident="t2-cln_68p1555"></elsevierMultimedia>DISCUSSIONThe present study aimed to investigate the associations between PhA, anthropometric measures, and lipid profile in patients chronically infected with HCV. In our study, the mid-arm circumference, mid-arm muscle circumference, and arm muscle area were associated with PhA. There was no association between PhA and lipid profile in these patients.PhA has been suggested as an indicator of cellular health, where higher values reflect higher cellularity, better cell membrane integrity, and better cell function. In healthy adults, age, gender, and BMI are the major determinants of PhA (<a class="elsevierStyleCrossRef" href="#bib7">7</a>). Because PhA is a marker of the amount and quality of soft tissue mass and hydration, it has been considered a useful indicator of nutritional status (<a class="elsevierStyleCrossRef" href="#bib7">7</a>).Several studies found a strong correlation between nutritional status and PhA in patients with gastrointestinal and renal diseases, older adult patients, and patients with anorexia nervosa (<a class="elsevierStyleCrossRef" href="#bib18">18</a>–<a class="elsevierStyleCrossRef" href="#bib21">21</a>). Maggiore et al. demonstrated in hemodialysis patients who albumin, age, subjective global assessment, and protein catabolic rate were associated with PhA (<a class="elsevierStyleCrossRef" href="#bib22">22</a>). However, other studies failed to show these associations (<a class="elsevierStyleCrossRef" href="#bib7">7</a>,<a class="elsevierStyleCrossRef" href="#bib23">23</a>).Despite these controversies concerning the results, a low PhA is associated with malnutrition, and mortality in some disease states. In patients with liver diseases, the association between PhA and nutritional status is not well established. In a study of cirrhotic patients with multiple etiologies, Selberg et al. showed that PhA discriminated poorly between cirrhosis patients of different Child-Pugh classes, although it was positively correlated with muscle area mass and muscle strength (<a class="elsevierStyleCrossRef" href="#bib6">6</a>).It is interesting to note that, in our study, there was no correlation between PhA and BMI, although PhA was positively correlated with MAMC and AMA. These results suggest that PhA is more closely correlated with lean body mass than with fat body mass in patients chronically infected with HCV.In addition to alterations in body composition, HCV infection and its treatment interfere with the lipid profile. Several studies showed that HCV infection may be associated with lower serum cholesterol and triglyceride levels (<a class="elsevierStyleCrossRef" href="#bib24">24</a>–<a class="elsevierStyleCrossRef" href="#bib25">25</a>). Some studies also demonstrated that the plasma lipid profile may be a predictor of therapeutic response in patients with HCV (<a class="elsevierStyleCrossRef" href="#bib26">26</a>–<a class="elsevierStyleCrossRef" href="#bib27">27</a>).Cholesterol and lipoproteins are required not only for the entry of HCV into hepatocytes but also for its viral assembly and replication (<a class="elsevierStyleCrossRef" href="#bib27">27</a>). The LDL receptor was reported to facilitate HCV endocytosis into the liver; thus, high LDL may compete with HCV and limit the spread of the virus in hepatocytes (<a class="elsevierStyleCrossRef" href="#bib28">28</a>). In addition, cholesterol is synthesized in the liver through the mevalonate pathway, which is also important for viral replication (<a class="elsevierStyleCrossRef" href="#bib2">2</a>).As stated previously, higher PhA values were associated with better nutritional status. In addition, higher levels of serum lipids were correlated with better outcomes in patients with HCV infection. Thus, our hypothesis was that PhA may also be associated with lipid profile in these patients. Despite all these studies, the relationship between the PhA and lipid profile in these patients has not yet been evaluated. In our study, PhA was not correlated with lipid profile when data were adjusted for age and gender. In agreement with our results, Santarpia et al. demonstrated the absence of a correlation between PhA and cholesterol in patients with advanced cancer (<a class="elsevierStyleCrossRef" href="#bib8">8</a>).An important implication of our results is that when BIA is not available, anthropometric measures, which can be used to estimate lean body mass, could be an alternative method of evaluating body composition in patients chronically infected with HCV.Finally, we should consider the major limitations of the present study, namely, its small sample size and the fact that all of the patients had undergone treatment at a single medical center. In addition, for the BIA, we used a single-frequency apparatus that may have led to biased results in patients with extracellular fluid overload.In conclusion, PhA was positively correlated with mid-arm circumference, mid-arm muscle circumference, and arm muscle area in our study. However, there was no association between PhA and lipid profile in these patients. Our results suggest that PhA is related to lean body mass in patients chronically infected with HCV.ACKNOWLEDGMENTSThis work was supported by CAPES (“Coordenação de Aperfeiçoamento de Pessoal de Nível Superior”)." "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "xpalclavsec1582071" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Subjects" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Assessment of Body Composition" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "Bioelectrical Impedance Analysis" ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "Lipid Profile Data" ] 4 => array:2 [ "identificador" => "cesec70" "titulo" => "Statistical Analysis" ] ] ] 3 => array:2 [ "identificador" => "cesec80" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec90" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec100" "titulo" => "ACKNOWLEDGMENTS" ] 6 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-06-11" "fechaAceptado" => "2013-07-18" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582071" "palabras" => array:5 [ 0 => "Phase Angle" 1 => "Hepatitis C" 2 => "Cholesterol" 3 => "Anthropometry" 4 => "Bioelectrical Impedance Analysis" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVE:The objective of this study was to investigate the associations between phase angle, anthropometric measurements, and lipid profile in patients chronically infected with the hepatitis C virus. METHODS:A total of 160 consecutive patients chronically infected with the hepatitis C virus and who received treatment at the hepatitis C outpatient unit of our hospital from April 2010 to May 2011 were prospectively evaluated. Bioelectrical impedance analysis, anthropometric measurements, and serum lipid profile analysis were performed. RESULTS:Twenty-five patients were excluded. A total of 135 patients with a mean age of 49.8±11.4 years were studied. Among these patients, 60% were male. The phase angle and BMI means were 6.5±0.8° and 26.5±4.8 kg/m2, respectively. Regarding anthropometric variables, mid-arm circumference, mid-arm muscle circumference, and arm muscle area had a positive correlation with phase angle. In contrast, when analyzing the lipid profile, only HDL was inversely correlated with phase angle. However, in multiple regression models adjusted for age and gender, only mid-arm circumference (p = 0.005), mid-arm muscle circumference (p = 0.003), and arm muscle circumference (p = 0.001) were associated with phase angle in hepatitis C virus-infected patients. CONCLUSIONS:In conclusion, phase angle is positively correlated with anthropometric measures in our study. However, there is no association between phase angle and lipid profile in these patients. Our results suggest that phase angle is related to lean body mass in patients chronically infected with hepatitis C virus." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVE:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHODS:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSIONS:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "Dorna MS collected the data and contributed to the conception and design of the study. Costa NA and Oliveira EP collected the data. Sassaki LY and Romeiro FG contributed to the design of the study and translation of the manuscript into English. Paiva SA performed the statistical analysis. Minicucci MF and Silva GF contributed to the conception and design of the study. No potential conflict of interest was reported." ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "t1-cln_68p1555" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "PhA: phase angle; total cholesterol: TC; HDL-cholesterol: HDL; triglycerides: TG; LDL-cholesterol: LDL; BMI: body mass index; MAC: mid-arm circumference; TSF: triceps skinfold; MAMC: mid-arm muscle circumference; AMA: arm muscle area. Data are expressed as the mean ± SD, median (lower to upper quartile), or percentage." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Results \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81 (60%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (y) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49.8±11.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PhA (°) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.5±0.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Resistance (Ohms) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">538.4±99.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reactance (Ohms) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60.8±11.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HDL (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.6±17.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TG (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">105 (79–142) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TC (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">160.5±34.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LDL (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">85.2±29.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.5±4.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MAC (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33.3±4.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TSF (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (13–30) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MAMC (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.9 (23.7–28.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AMA (mm2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45.5 (38–56.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Demographic, anthropometric, and laboratory data from 135 patients with HCV." ] ] 1 => array:7 [ "identificador" => "t2-cln_68p1555" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "Total cholesterol: TC; HDL-cholesterol: HDL; triglycerides: TG; LDL-cholesterol: LDL; BMI: body mass index; MAC: mid-arm circumference; TSF: triceps skinfold; MAMC: mid-arm muscle circumference; AMA: arm muscle area." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Coefficient \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Standard Error \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TC (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.189 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HDL (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.004 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.075 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LDL (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.0002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.899 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TG (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.212 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0208 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0118 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.079 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MAC (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0400 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0140 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TSF (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0042 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0062 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.500 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MAMC (cm2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0564 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0184 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="justify" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AMA (mm2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0145 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0042 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Multiple linear regression models for phase angle prediction, adjusted for gender and age." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eradication of hepatitic C virus by interferon improves whole-body insulin resistance and hyperinsulinaemia in patients with chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ Y Kawaguchi \n \t\t\t\t\t\t\t\t """ 1 => """ T Mizuta \n \t\t\t\t\t\t\t\t """ 2 => """ N Oza \n \t\t\t\t\t\t\t\t """ 3 => """ H Takahashi \n \t\t\t\t\t\t\t\t """ 4 => """ K Ario \n \t\t\t\t\t\t\t\t """ 5 => """ T Yoshimura \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Liver Inter" "fecha" => "2009" "volumen" => "29" "numero" => "6" "paginaInicial" => "871" "paginaFinal" => "877" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of piginterferon alpha and ribavirin treatment on lipid profiles and insulin resistance in hepatitis C virus/HIV-coinfected persons: The AIDS clinical trials group A5178 study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ AA Butt \n \t\t\t\t\t\t\t\t """ 1 => """ T Umbleja \n \t\t\t\t\t\t\t\t """ 2 => """ JW Andersen \n \t\t\t\t\t\t\t\t """ 3 => """ KE Sherman \n \t\t\t\t\t\t\t\t """ 4 => """ TR Chung \n \t\t\t\t\t\t\t\t """ 5 => """ ACTG A5178 Study Team \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CID" "fecha" => "2012" "volumen" => "55" "numero" => "5" "paginaInicial" => "631" "paginaFinal" => "638" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversal hypolipidemia in chronic hepatitis C patients after successful antiviral therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ YH Kuo \n \t\t\t\t\t\t\t\t """ 1 => """ TW Chuang \n \t\t\t\t\t\t\t\t """ 2 => """ CH Hung \n \t\t\t\t\t\t\t\t """ 3 => """ CH Cheng \n \t\t\t\t\t\t\t\t """ 4 => """ JH Wang \n \t\t\t\t\t\t\t\t """ 5 => """ TH Hu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0929-6646(11)60054-5" "Revista" => array:7 [ "tituloSerie" => "J Formos Med Assoc" "fecha" => "2012" "volumen" => "110" "numero" => "6" "paginaInicial" => "363" "paginaFinal" => "371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21741004" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatitis C virus infection and its clearance alter circulating lipids: implications for long term follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ KE Corey \n \t\t\t\t\t\t\t\t """ 1 => """ E Kane \n \t\t\t\t\t\t\t\t """ 2 => """ C Munroe \n \t\t\t\t\t\t\t\t """ 3 => """ LL Barlow \n \t\t\t\t\t\t\t\t """ 4 => """ H Zheng \n \t\t\t\t\t\t\t\t """ 5 => """ RT Chung \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.23219" "Revista" => array:8 [ "tituloSerie" => "Hepatology" "fecha" => "2009" "volumen" => "50" "numero" => "4" "paginaInicial" => "1030" "paginaFinal" => "1037" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19787818" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0885392418304688" "estado" => "S300" "issn" => "08853924" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of nutritional status and diagnosis of malnutrition in patients with liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ B Campillo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "V RPreedy, RLakshman, RSrirajaskanthan, R RWatson" "titulo" => "Nutrition, Diet Therapy and The Liver" "paginaInicial" => "33" "paginaFinal" => "46" "edicion" => "First Edition" "serieFecha" => "2010" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Norms and correlates of bioimpedance phase angle in healthy human subjects, hospitalized patients, and patients with liver cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ O Selberg \n \t\t\t\t\t\t\t\t """ 1 => """ D Selberg \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00421-001-0570-4" "Revista" => array:7 [ "tituloSerie" => "Eur J Appl Physiol" "fecha" => "2002" "volumen" => "86" "numero" => "6" "paginaInicial" => "509" "paginaFinal" => "516" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11944099" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bioelectrical phase angle and impedance vector analysis- clinical relevance and applicability of impedance parameters" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ K Norman \n \t\t\t\t\t\t\t\t """ 1 => """ N Stobäus \n \t\t\t\t\t\t\t\t """ 2 => """ M Pirlich \n \t\t\t\t\t\t\t\t """ 3 => """ A Bosy-Whestphal \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clnu.2012.05.008" "Revista" => array:7 [ "tituloSerie" => "Clin Nutr" "fecha" => "2012" "volumen" => "31" "numero" => "6" "paginaInicial" => "854" "paginaFinal" => "861" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22698802" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of bioelectrical phase angle in advanced câncer: preliminar observations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ L Santarpia \n \t\t\t\t\t\t\t\t """ 1 => """ M Marra \n \t\t\t\t\t\t\t\t """ 2 => """ C Montagnese \n \t\t\t\t\t\t\t\t """ 3 => """ L Alfonsi \n \t\t\t\t\t\t\t\t """ 4 => """ F Pasanisi \n \t\t\t\t\t\t\t\t """ 5 => """ F Contaldo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.nut.2009.01.015" "Revista" => array:7 [ "tituloSerie" => "Nutrition" "fecha" => "2009" "volumen" => "25" "numero" => "9" "paginaInicial" => "930" "paginaFinal" => "931" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19500944" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bioelectrical impedance analysis in clinical practice: a new perspective on its use beyond body composition equations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ MC Barbosa-Silva \n \t\t\t\t\t\t\t\t """ 1 => """ AJ Barros \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.mco.0000165011.69943.39" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Clin Nutr Metab Care" "fecha" => "2005" "volumen" => "8" "numero" => "3" "paginaInicial" => "311" "paginaFinal" => "317" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15809535" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low phase angle determined by bioelectrical impedance analysis is associated with malnutrition and nutritional risk at hospital admission" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ UG Kyle \n \t\t\t\t\t\t\t\t """ 1 => """ L Genton \n \t\t\t\t\t\t\t\t """ 2 => """ C Pichard \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Nutr" "fecha" => "2013" "volumen" => "32" "numero" => "2" "paginaInicial" => "194" "paginaFinal" => "199" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Espen Guidelines on Enteral Nutrition: Liver Disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ M Plauth \n \t\t\t\t\t\t\t\t """ 1 => """ E Cabré \n \t\t\t\t\t\t\t\t """ 2 => """ O Riggio \n \t\t\t\t\t\t\t\t """ 3 => """ M Assis-Camilo \n \t\t\t\t\t\t\t\t """ 4 => """ M Pirlich \n \t\t\t\t\t\t\t\t """ 5 => """ J Kondrup \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clnu.2006.01.018" "Revista" => array:8 [ "tituloSerie" => "Clin Nutr" "fecha" => "2006" "volumen" => "25" "numero" => "2" "paginaInicial" => "285" "paginaFinal" => "294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16707194" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022399918307050" "estado" => "S300" "issn" => "00223999" ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bioelectrical impedance analysis in clinical practice:implications for hepatitis C therapy BIA and hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ A Kahraman \n \t\t\t\t\t\t\t\t """ 1 => """ J Hilsenbeck \n \t\t\t\t\t\t\t\t """ 2 => """ M Nyga \n \t\t\t\t\t\t\t\t """ 3 => """ J Ertle \n \t\t\t\t\t\t\t\t """ 4 => """ A Wree \n \t\t\t\t\t\t\t\t """ 5 => """ M Plauth \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Virol J" "fecha" => "2010" "volumen" => "16" "numero" => "7" "paginaInicial" => "191" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity:preventing and managing the global epidemic" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ World Health Organization \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1997" "editorial" => "World Health Organization" "editorialLocalizacion" => "Geneva" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Circumferences" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ CW Callaway \n \t\t\t\t\t\t\t\t """ 1 => """ WC Chumlea \n \t\t\t\t\t\t\t\t """ 2 => """ C Bouchard \n \t\t\t\t\t\t\t\t """ 3 => """ JH Himes \n \t\t\t\t\t\t\t\t """ 4 => """ TG Lohman \n \t\t\t\t\t\t\t\t """ 5 => """ AD Martin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "T GLohman, A FRoche, RMartorell" "titulo" => "Anthropometric standardizing reference manual" "paginaInicial" => "39" "paginaFinal" => "54" "serieFecha" => "1991" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skinfold thicknesses and measurements technique" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ GG Harrison \n \t\t\t\t\t\t\t\t """ 1 => """ EK Buskirk \n \t\t\t\t\t\t\t\t """ 2 => """ JEL Carter \n \t\t\t\t\t\t\t\t """ 3 => """ JFE Ohmston \n \t\t\t\t\t\t\t\t """ 4 => """ TG Lohman \n \t\t\t\t\t\t\t\t """ 5 => """ ML Pollock \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "T GLohman, A FRoche, RMartorell" "titulo" => "Anthropometric standardizing reference manual" "paginaInicial" => "55" "paginaFinal" => "80" "serieFecha" => "1991" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anthropometric standards for the assessment of growth and nutritional status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ AR Frisancho \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ "fecha" => "1990" "paginaInicial" => "48" "paginaFinal" => "53" "editorial" => "The University of Michigan Press" "editorialLocalizacion" => "Michigan" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Can phase angle determined by bioelectrical impedance analysis assess nutritional risk" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ UG Kyle \n \t\t\t\t\t\t\t\t """ 1 => """ EP Soundar \n \t\t\t\t\t\t\t\t """ 2 => """ L Genton \n \t\t\t\t\t\t\t\t """ 3 => """ C Pichard \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clnu.2012.04.002" "Revista" => array:7 [ "tituloSerie" => "A comparison between healthy and hospitalized subjects. Clin Nutr" "fecha" => "2012" "volumen" => "31" "numero" => "6" "paginaInicial" => "875" "paginaFinal" => "881" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22560739" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The phase angle and mass body cell as markers of nutritional status in hemodialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ CM Oliveira \n \t\t\t\t\t\t\t\t """ 1 => """ M Kubrusly \n \t\t\t\t\t\t\t\t """ 2 => """ RS Mota \n \t\t\t\t\t\t\t\t """ 3 => """ CA Silva \n \t\t\t\t\t\t\t\t """ 4 => """ G Choukroun \n \t\t\t\t\t\t\t\t """ 5 => """ VN Oliveira \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.jrn.2010.01.008" "Revista" => array:7 [ "tituloSerie" => "J Ren Nutr" "fecha" => "2010" "volumen" => "20" "numero" => "5" "paginaInicial" => "314" "paginaFinal" => "320" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20303790" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is bioelectrical impedance vector analysis of value in the elderly with malnutrition and impaired functionality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ K Norman \n \t\t\t\t\t\t\t\t """ 1 => """ C Smoliner \n \t\t\t\t\t\t\t\t """ 2 => """ L Valentini \n \t\t\t\t\t\t\t\t """ 3 => """ H Lochs \n \t\t\t\t\t\t\t\t """ 4 => """ M Pirlich \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.nut.2007.05.007" "Revista" => array:7 [ "tituloSerie" => "Nutrition" "fecha" => "2007" "volumen" => "23" "numero" => "7-8" "paginaInicial" => "564" "paginaFinal" => "569" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17616343" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disease-related malnutrition but not underweight by BMI is reflected by disturbed electric tissue properties in the bioelectrical impedance vector analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ K Norman \n \t\t\t\t\t\t\t\t """ 1 => """ C Smoliner \n \t\t\t\t\t\t\t\t """ 2 => """ A Kilbert \n \t\t\t\t\t\t\t\t """ 3 => """ L Valentini \n \t\t\t\t\t\t\t\t """ 4 => """ H Lochs \n \t\t\t\t\t\t\t\t """ 5 => """ M Pirlich \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S0007114508911545" "Revista" => array:7 [ "tituloSerie" => "Br J Nutr" "fecha" => "2008" "volumen" => "100" "numero" => "3" "paginaInicial" => "590" "paginaFinal" => "595" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18234142" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in bioimpedance analysis after stable refeeding of undernourished anorexic patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ L Scalfi \n \t\t\t\t\t\t\t\t """ 1 => """ M Marra \n \t\t\t\t\t\t\t\t """ 2 => """ A Caldara \n \t\t\t\t\t\t\t\t """ 3 => """ E Silvestri \n \t\t\t\t\t\t\t\t """ 4 => """ F Contaldo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ijo.0800780" "Revista" => array:7 [ "tituloSerie" => "Int J Obes Relat Metab Disord" "fecha" => "1999" "volumen" => "23" "numero" => "2" "paginaInicial" => "133" "paginaFinal" => "137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10078846" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nutritional and prognostic correlates of bioimpedance indexes in hemodialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ Q Maggiore \n \t\t\t\t\t\t\t\t """ 1 => """ S Nigrelli \n \t\t\t\t\t\t\t\t """ 2 => """ C Ciccarelli \n \t\t\t\t\t\t\t\t """ 3 => """ C Grimaldi \n \t\t\t\t\t\t\t\t """ 4 => """ GA Rossi \n \t\t\t\t\t\t\t\t """ 5 => """ C Michelassi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.1996.535" "Revista" => array:7 [ "tituloSerie" => "Kidney Int" "fecha" => "1996" "volumen" => "50" "numero" => "6" "paginaInicial" => "2103" "paginaFinal" => "2108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8943496" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship between bioelectrical impedance phase angle and subjective global assessment in advanced colorectal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ D Gupta \n \t\t\t\t\t\t\t\t """ 1 => """ CG Lis \n \t\t\t\t\t\t\t\t """ 2 => """ SL Dahlk \n \t\t\t\t\t\t\t\t """ 3 => """ J King \n \t\t\t\t\t\t\t\t """ 4 => """ PG Vashi \n \t\t\t\t\t\t\t\t """ 5 => """ J Grutsch \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nutr J" "fecha" => "2008" "volumen" => "30" "numero" => "7" "paginaInicial" => "19" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ G Perlemuter \n \t\t\t\t\t\t\t\t """ 1 => """ A Sabile \n \t\t\t\t\t\t\t\t """ 2 => """ P Letteron \n \t\t\t\t\t\t\t\t """ 3 => """ G Voga \n \t\t\t\t\t\t\t\t """ 4 => """ A Topillo \n \t\t\t\t\t\t\t\t """ 5 => """ Y Chrétien \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1096/fj.01-0396com" "Revista" => array:7 [ "tituloSerie" => "FASEB J" "fecha" => "2002" "volumen" => "16" "numero" => "2" "paginaInicial" => "185" "paginaFinal" => "194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11818366" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolic profiles in patients with chronic hepatitis C: a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ CS Hsu \n \t\t\t\t\t\t\t\t """ 1 => """ CJ Liu \n \t\t\t\t\t\t\t\t """ 2 => """ CH Liu \n \t\t\t\t\t\t\t\t """ 3 => """ CL Chen \n \t\t\t\t\t\t\t\t """ 4 => """ MY Lai \n \t\t\t\t\t\t\t\t """ 5 => """ PJ Chen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s12072-008-9064-3" "Revista" => array:7 [ "tituloSerie" => "Hepatol Int" "fecha" => "2008" "volumen" => "2" "numero" => "2" "paginaInicial" => "250" "paginaFinal" => "257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19669312" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between beta-lipoprotein levels and outcome of hepatitis C treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ K Gopal \n \t\t\t\t\t\t\t\t """ 1 => """ TC Johnson \n \t\t\t\t\t\t\t\t """ 2 => """ S Gopal \n \t\t\t\t\t\t\t\t """ 3 => """ A Wasfish \n \t\t\t\t\t\t\t\t """ 4 => """ CT Bang \n \t\t\t\t\t\t\t\t """ 5 => """ P Suwandhi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.21261" "Revista" => array:7 [ "tituloSerie" => "Hepatology" "fecha" => "2006" "volumen" => "44" "numero" => "2" "paginaInicial" => "335" "paginaFinal" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16871569" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversal of hypolipidemia in chronic hepatitis C patients after successful antiviral therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ YH Kuo \n \t\t\t\t\t\t\t\t """ 1 => """ TW Chuang \n \t\t\t\t\t\t\t\t """ 2 => """ CH Hung \n \t\t\t\t\t\t\t\t """ 3 => """ CH Chen \n \t\t\t\t\t\t\t\t """ 4 => """ JH Wang \n \t\t\t\t\t\t\t\t """ 5 => """ TH Hu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0929-6646(11)60054-5" "Revista" => array:7 [ "tituloSerie" => "J Formos Med Assoc" "fecha" => "2011" "volumen" => "110" "numero" => "6" "paginaInicial" => "363" "paginaFinal" => "371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21741004" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of low- and very-low-density hepatitis C virus RNA-containing particles" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ P André \n \t\t\t\t\t\t\t\t """ 1 => """ F Komurian-Pradel \n \t\t\t\t\t\t\t\t """ 2 => """ S Deforges \n \t\t\t\t\t\t\t\t """ 3 => """ M Perret \n \t\t\t\t\t\t\t\t """ 4 => """ JL Berland \n \t\t\t\t\t\t\t\t """ 5 => """ M Sodoyer \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/jvi.76.14.6919-6928.2002" "Revista" => array:7 [ "tituloSerie" => "J Virol" "fecha" => "2002" "volumen" => "76" "numero" => "14" "paginaInicial" => "6919" "paginaFinal" => "6928" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12072493" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020452/v1_202212011241/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006800000012/v1_202212011241/S1807593222020452/v1_202212011241/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020452?idApp=UINPBA00004N"]

Statistics

RAPID COMMUNICATION

Mariana de Souza DornaI,

Corresponding author

mari_dorna@yahoo.com.br

Tel.: 014 3822-2969

, Nara Aline CostaI, Erick Prado de OliveiraII, Ligia Yukie SassakiI, Fernando Gomes RomeiroI, Sergio Alberto Rupp de PaivaI, Marcos Ferreira MinicucciI, Giovanni Faria SilvaI

I Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Department of Internal Medicine, Botucatu/SP, Brazil.

II School of Medicine, Federal University of Uberlandia, Uberlandia/MG, Brazil.

Read

866

Times
was read the article

290

Total PDF

576

Total HTML

Share statistics

 array:24 [
  "pii" => "S1807593222020452"
  "issn" => "18075932"
  "doi" => "10.6061/clinics/2013(12)13"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "aid" => "2045"
  "copyright" => "CLINICS"
  "copyrightAnyo" => "2013"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
  "subdocumento" => "fla"
  "cita" => "Clinics. 2013;68:1555-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1807593222020464"
    "issn" => "18075932"
    "doi" => "10.6061/clinics/2013(12)14"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "2046"
    "copyright" => "CLINICS"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "err"
    "cita" => "Clinics. 2013;68:1559-60"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ERRATA</span>"
      "titulo" => "ERRATA"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1559"
          "paginaFinal" => "1560"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020464?idApp=UINPBA00004N"
    "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020464/v1_202212011241/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1807593222020440"
    "issn" => "18075932"
    "doi" => "10.6061/clinics/2013(12)12"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "2044"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2013;68:1548-54"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">BASIC RESEARCH</span>"
      "titulo" => "Local and remote ischemic preconditioning protect against intestinal ischemic&#47;reperfusion injury after supraceliac aortic clamping"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1548"
          "paginaFinal" => "1554"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 731
              "Ancho" => 722
              "Tamanyo" => 49524
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Experimental protocol &#40;A&#41; and main arterial pressure variations during the experiment in the control&#44; ischemia and reperfusion &#40;IR&#41;&#44; local ischemic preconditioning &#40;LIPC&#41;&#44; and remote ischemic preconditioning &#40;RIPC&#41; groups &#40;B&#41;&#46; Data are expressed as the mean &#177; SE for 7 animals per group&#46; &#40;&#42;&#41; <span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#58; IR&#44; LIPC&#44; and RIPC <span class="elsevierStyleItalic">vs</span>&#46; control&#44; &#40;&#8224;&#41; <span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#58; LIPC <span class="elsevierStyleItalic">vs</span>&#46; control&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Nilon Erling, Edna Frasson de Souza Montero, Paulina Sannomiya, Luiz Francisco Poli-de-Figueiredo &#40;in memoriam&#41;"
          "autores" => array:4 [
            0 => array:3 [
              "nombre" => "Nilon"
              "apellidos" => "Erling"
              "sufijo" => "Junior"
            ]
            1 => array:2 [
              "nombre" => "Edna Frasson"
              "apellidos" => "de Souza Montero"
            ]
            2 => array:2 [
              "nombre" => "Paulina"
              "apellidos" => "Sannomiya"
            ]
            3 => array:2 [
              "nombre" => "Luiz Francisco"
              "apellidos" => "Poli-de-Figueiredo &#40;in memoriam&#41;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020440?idApp=UINPBA00004N"
    "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020440/v1_202212011241/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">RAPID COMMUNICATION</span>"
    "titulo" => "Association between phase angle&#44; anthropometric measurements&#44; and lipid profile in HCV-infected patients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "1555"
        "paginaFinal" => "1558"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mariana de Souza Dorna, Nara Aline Costa, Erick Prado de Oliveira, Ligia Yukie Sassaki, Fernando Gomes Romeiro, Sergio Alberto Rupp de Paiva, Marcos Ferreira Minicucci, Giovanni Faria Silva"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Mariana"
            "apellidos" => "de Souza Dorna"
            "email" => array:1 [
              0 => "mari_dorna@yahoo.com.br"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Nara Aline"
            "apellidos" => "Costa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Erick Prado"
            "apellidos" => "de Oliveira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">II</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ligia Yukie"
            "apellidos" => "Sassaki"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Fernando Gomes"
            "apellidos" => "Romeiro"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Sergio Alberto Rupp"
            "apellidos" => "de Paiva"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Marcos Ferreira"
            "apellidos" => "Minicucci"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Giovanni Faria"
            "apellidos" => "Silva"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Universidade Estadual Paulista J&#250;lio de Mesquita Filho &#40;UNESP&#41;&#44; Department of Internal Medicine&#44; Botucatu&#47;SP&#44; Brazil&#46;"
            "etiqueta" => "I"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "School of Medicine&#44; Federal University of Uberlandia&#44; Uberlandia&#47;MG&#44; Brazil&#46;"
            "etiqueta" => "II"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Tel&#46;&#58; 014 3822-2969"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">It is estimated that over 170 million people worldwide have hepatitis C in its chronic form &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41;&#46; Currently&#44; aside from the established consequence of liver injury&#44; chronic hepatitis C virus &#40;HCV&#41; infection is associated with some metabolic disorders&#46; Several studies have highlighted the association between HCV infection and lipid metabolism&#59; however&#44; the relationship between lipid profile and body composition in HCV carriers is less clear &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#8211;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41;&#46; Although the importance of nutritional assessment in this population is known&#44; there is not yet a gold standard tool for assessing body composition in these subjects &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41;&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">For more than 20 years&#44; bioelectrical impedance analysis &#40;BIA&#41; has been used to assess body composition in several clinical situations&#46; BIA measures the resistance to the movement of an electrical current through the body&#44; allowing for the determination of the fat-free mass and total body water&#46; The body offers two types of resistance to an electrical current&#44; namely&#44; capacitive Xc &#40;reactance&#41; and resistive &#40;simply called resistance&#41; resistance&#46; One measurement of the relationship between capacitance and resistance is the phase angle &#40;PhA&#41;&#44; and its association with clinical outcomes has already been shown in different pathological situations &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#8211;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#41;&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">There are few studies that have evaluated the association between PhA&#44; anthropometric measures&#44; and outcomes in patients with chronic liver disease&#46; Selberg et al&#46; showed that PhA was poorly correlated with disease severity &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#46; However&#44; in their study&#44; PhA was correlated with muscle mass and strength &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#46; In addition&#44; Kahraman et al&#46; evaluated 37 consecutive patients with HCV infection and showed that PhA reduction was associated with increased side effects following pegylated interferon-&#945; and ribavirin treatment &#40;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#41;&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">Although BIA is non-invasive&#44; easy-to-use&#44; portable&#44; and inexpensive&#44; this device is not available at all centers&#46; Thus&#44; in this scenario&#44; anthropometric measures are one method for evaluating body composition &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41;&#46; Despite the association between PhA and anthropometric data&#44; chronically infected HCV patients have not yet been evaluated&#46;</p><p id="para50" class="elsevierStylePara elsevierViewall">Therefore&#44; the present study aimed to investigate the associations between PhA&#44; anthropometric measures&#44; and lipid profile in patients chronically infected with HCV&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">MATERIALS AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Subjects</span><p id="para60" class="elsevierStylePara elsevierViewall">The present study was approved by the ethics committee of our institution&#44; and written informed consent was obtained from all subjects&#46; All patients chronically infected with HCV who underwent treatment at the hepatitis C outpatient unit of our hospital from April 2010 to May 2011 were prospectively evaluated&#46; The inclusion criteria were na&#239;ve patients or lack of treatment with pegylated interferon and ribavirin for at least 1 year&#44; completion of liver biopsy&#44; and clinical diagnosis of liver cirrhosis&#46; The exclusion criteria were liver cirrhosis with ascites&#44; hepatitis B virus infection&#44; HIV infection&#44; chronic kidney disease&#44; heart failure&#44; and pregnancy&#46; Bioelectrical impedance analysis and anthropometric measurements were performed during the first hospital visit&#46; The lipid profile was considered in cases where it had been measured up to three months prior to the evaluation&#46;</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Assessment of Body Composition</span><p id="para70" class="elsevierStylePara elsevierViewall">Body height and weight were measured and used to calculate the body mass index &#40;BMI&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41;&#46; Mid-arm circumference &#40;MAC&#41; was measured using a measuring tape&#44; as previously described &#40;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#41;&#46; Triceps skinfold &#40;TSF&#41; was measured according to the standardization of Harrison et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#46; Mid-arm muscle circumference &#40;MAMC&#41; and arm muscle area &#40;AMA&#41; were obtained from the following respective formulas&#58; MAMC&#8202;&#61;&#8202;MAC-&#40;&#960; x TSF&#41; and MAMC&#8202;&#61;&#8202;MAC-&#960;x&#40;TSF&#47;10&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib16">16</a>&#41;&#46; All measurements were performed by the same researcher&#46;</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Bioelectrical Impedance Analysis</span><p id="para80" class="elsevierStylePara elsevierViewall">BIA was conducted using a tetrapolar single-frequency apparatus &#40;Biodynamic-450&#44; Biodynamics Corporation&#44; USA&#41; that was applied to the skin using adhesive electrodes with the subject lying supine&#46; PhA derived from the BIA was determined as previously described &#40;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#41;&#44; and its values were calculated as follows&#58; PhA&#8202;&#61;&#8202;&#40;arc tangent reactance&#47;resistance &#42; &#40;180&#176;&#47;&#960;&#41;&#41;&#46;</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Lipid Profile Data</span><p id="para90" class="elsevierStylePara elsevierViewall">Total cholesterol &#40;TC&#41;&#44; HDL-cholesterol &#40;HDL&#41;&#44; and triglycerides &#40;TG&#41; were measured using a dry-chemistry method&#46; LDL-cholesterol &#40;LDL&#41; was calculated by the Friedwald formula&#46;</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">Statistical Analysis</span><p id="para100" class="elsevierStylePara elsevierViewall">Data are expressed as the mean &#177; SD or the median &#40;including the lower and upper quartiles&#41;&#46; The Spearman correlation was employed to evaluate the association between continuous variables&#46; Multiple linear regressions were used for PhA prediction and adjusted for gender and age&#46; Data analysis was performed using Sigma Stat 3&#46;5 for Windows &#40;Systat Software&#44; Inc&#46;&#44; San Jose&#44; CA&#44; USA&#41;&#46; P values lower than 0&#46;05 were considered statistically significant&#46;</p></span></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">RESULTS</span><p id="para110" class="elsevierStylePara elsevierViewall">Of the 160 consecutive patients initially evaluated&#44; 25 were excluded &#40;10 had incomplete data&#44; 4 had not undergone liver biopsy&#44; 8 had ascites&#44; 1 was physically disabled&#44; 1 had chronic kidney disease and 1 had heart failure&#41;&#46; Thus&#44; a total of 135 patients with a mean age of 49&#46;8&#177;11&#46;4 y were assessed&#46; Demographic&#44; anthropometric&#44; and laboratory data are listed in <a class="elsevierStyleCrossRef" href="#t1-cln_68p1555">Table&#160;1</a>&#46; Of the included patients&#44; 60&#37; were male&#46; The PhA and BMI means were 6&#46;5&#177;0&#46;8&#176; and 26&#46;5&#177;4&#46;8 kg&#47;m<span class="elsevierStyleSup">2</span>&#44; respectively&#46;</p><elsevierMultimedia ident="t1-cln_68p1555"></elsevierMultimedia><p id="para120" class="elsevierStylePara elsevierViewall">With regard to anthropometric variables&#44; MAC&#44; MAMC&#44; and AMA presented a positive correlation with PhA&#46; In contrast&#44; when analyzing the lipid profile&#44; only HDL was inversely correlated with PhA&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">However&#44; in multiple regression models adjusted for age and gender&#44; only MAC &#40;<span class="elsevierStyleItalic">p</span>&#8202;&#61;&#8202;0&#46;005&#41;&#44; MAMC &#40;<span class="elsevierStyleItalic">p</span>&#8202;&#61;&#8202;0&#46;003&#41;&#44; and AMA &#40;<span class="elsevierStyleItalic">p</span>&#8202;&#61;&#8202;0&#46;001&#41; were associated with PhA in HCV-infected patients &#40;<a class="elsevierStyleCrossRef" href="#t2-cln_68p1555">Table&#160;2</a>&#41;&#46;</p><elsevierMultimedia ident="t2-cln_68p1555"></elsevierMultimedia></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">DISCUSSION</span><p id="para140" class="elsevierStylePara elsevierViewall">The present study aimed to investigate the associations between PhA&#44; anthropometric measures&#44; and lipid profile in patients chronically infected with HCV&#46; In our study&#44; the mid-arm circumference&#44; mid-arm muscle circumference&#44; and arm muscle area were associated with PhA&#46; There was no association between PhA and lipid profile in these patients&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">PhA has been suggested as an indicator of cellular health&#44; where higher values reflect higher cellularity&#44; better cell membrane integrity&#44; and better cell function&#46; In healthy adults&#44; age&#44; gender&#44; and BMI are the major determinants of PhA &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41;&#46; Because PhA is a marker of the amount and quality of soft tissue mass and hydration&#44; it has been considered a useful indicator of nutritional status &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41;&#46;</p><p id="para160" class="elsevierStylePara elsevierViewall">Several studies found a strong correlation between nutritional status and PhA in patients with gastrointestinal and renal diseases&#44; older adult patients&#44; and patients with anorexia nervosa &#40;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#8211;<a class="elsevierStyleCrossRef" href="#bib21">21</a>&#41;&#46; Maggiore et al&#46; demonstrated in hemodialysis patients who albumin&#44; age&#44; subjective global assessment&#44; and protein catabolic rate were associated with PhA &#40;<a class="elsevierStyleCrossRef" href="#bib22">22</a>&#41;&#46; However&#44; other studies failed to show these associations &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#44;<a class="elsevierStyleCrossRef" href="#bib23">23</a>&#41;&#46;</p><p id="para170" class="elsevierStylePara elsevierViewall">Despite these controversies concerning the results&#44; a low PhA is associated with malnutrition&#44; and mortality in some disease states&#46; In patients with liver diseases&#44; the association between PhA and nutritional status is not well established&#46; In a study of cirrhotic patients with multiple etiologies&#44; Selberg et al&#46; showed that PhA discriminated poorly between cirrhosis patients of different Child-Pugh classes&#44; although it was positively correlated with muscle area mass and muscle strength &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#46;</p><p id="para180" class="elsevierStylePara elsevierViewall">It is interesting to note that&#44; in our study&#44; there was no correlation between PhA and BMI&#44; although PhA was positively correlated with MAMC and AMA&#46; These results suggest that PhA is more closely correlated with lean body mass than with fat body mass in patients chronically infected with HCV&#46;</p><p id="para190" class="elsevierStylePara elsevierViewall">In addition to alterations in body composition&#44; HCV infection and its treatment interfere with the lipid profile&#46; Several studies showed that HCV infection may be associated with lower serum cholesterol and triglyceride levels &#40;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#8211;<a class="elsevierStyleCrossRef" href="#bib25">25</a>&#41;&#46; Some studies also demonstrated that the plasma lipid profile may be a predictor of therapeutic response in patients with HCV &#40;<a class="elsevierStyleCrossRef" href="#bib26">26</a>&#8211;<a class="elsevierStyleCrossRef" href="#bib27">27</a>&#41;&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">Cholesterol and lipoproteins are required not only for the entry of HCV into hepatocytes but also for its viral assembly and replication &#40;<a class="elsevierStyleCrossRef" href="#bib27">27</a>&#41;&#46; The LDL receptor was reported to facilitate HCV endocytosis into the liver&#59; thus&#44; high LDL may compete with HCV and limit the spread of the virus in hepatocytes &#40;<a class="elsevierStyleCrossRef" href="#bib28">28</a>&#41;&#46; In addition&#44; cholesterol is synthesized in the liver through the mevalonate pathway&#44; which is also important for viral replication &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41;&#46;</p><p id="para210" class="elsevierStylePara elsevierViewall">As stated previously&#44; higher PhA values were associated with better nutritional status&#46; In addition&#44; higher levels of serum lipids were correlated with better outcomes in patients with HCV infection&#46; Thus&#44; our hypothesis was that PhA may also be associated with lipid profile in these patients&#46; Despite all these studies&#44; the relationship between the PhA and lipid profile in these patients has not yet been evaluated&#46; In our study&#44; PhA was not correlated with lipid profile when data were adjusted for age and gender&#46; In agreement with our results&#44; Santarpia et al&#46; demonstrated the absence of a correlation between PhA and cholesterol in patients with advanced cancer &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall">An important implication of our results is that when BIA is not available&#44; anthropometric measures&#44; which can be used to estimate lean body mass&#44; could be an alternative method of evaluating body composition in patients chronically infected with HCV&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">Finally&#44; we should consider the major limitations of the present study&#44; namely&#44; its small sample size and the fact that all of the patients had undergone treatment at a single medical center&#46; In addition&#44; for the BIA&#44; we used a single-frequency apparatus that may have led to biased results in patients with extracellular fluid overload&#46;</p><p id="para240" class="elsevierStylePara elsevierViewall">In conclusion&#44; PhA was positively correlated with mid-arm circumference&#44; mid-arm muscle circumference&#44; and arm muscle area in our study&#46; However&#44; there was no association between PhA and lipid profile in these patients&#46; Our results suggest that PhA is related to lean body mass in patients chronically infected with HCV&#46;</p></span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">ACKNOWLEDGMENTS</span><p id="para250" class="elsevierStylePara elsevierViewall">This work was supported by CAPES &#40;&#8220;Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoal de N&#237;vel Superior&#8221;&#41;&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:7 [
        0 => array:2 [
          "identificador" => "xpalclavsec1582071"
          "titulo" => "KEYWORDS"
        ]
        1 => array:2 [
          "identificador" => "cesec10"
          "titulo" => "INTRODUCTION"
        ]
        2 => array:3 [
          "identificador" => "cesec20"
          "titulo" => "MATERIALS AND METHODS"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "cesec30"
              "titulo" => "Subjects"
            ]
            1 => array:2 [
              "identificador" => "cesec40"
              "titulo" => "Assessment of Body Composition"
            ]
            2 => array:2 [
              "identificador" => "cesec50"
              "titulo" => "Bioelectrical Impedance Analysis"
            ]
            3 => array:2 [
              "identificador" => "cesec60"
              "titulo" => "Lipid Profile Data"
            ]
            4 => array:2 [
              "identificador" => "cesec70"
              "titulo" => "Statistical Analysis"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "cesec80"
          "titulo" => "RESULTS"
        ]
        4 => array:2 [
          "identificador" => "cesec90"
          "titulo" => "DISCUSSION"
        ]
        5 => array:2 [
          "identificador" => "cesec100"
          "titulo" => "ACKNOWLEDGMENTS"
        ]
        6 => array:1 [
          "titulo" => "REFERENCES"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-06-11"
    "fechaAceptado" => "2013-07-18"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1582071"
          "palabras" => array:5 [
            0 => "Phase Angle"
            1 => "Hepatitis C"
            2 => "Cholesterol"
            3 => "Anthropometry"
            4 => "Bioelectrical Impedance Analysis"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVE&#58;</span><p id="spara50" class="elsevierStyleSimplePara elsevierViewall">The objective of this study was to investigate the associations between phase angle&#44; anthropometric measurements&#44; and lipid profile in patients chronically infected with the hepatitis C virus&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS&#58;</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">A total of 160 consecutive patients chronically infected with the hepatitis C virus and who received treatment at the hepatitis C outpatient unit of our hospital from April 2010 to May 2011 were prospectively evaluated&#46; Bioelectrical impedance analysis&#44; anthropometric measurements&#44; and serum lipid profile analysis were performed&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Twenty-five patients were excluded&#46; A total of 135 patients with a mean age of 49&#46;8&#177;11&#46;4 years were studied&#46; Among these patients&#44; 60&#37; were male&#46; The phase angle and BMI means were 6&#46;5&#177;0&#46;8&#176; and 26&#46;5&#177;4&#46;8 kg&#47;m<span class="elsevierStyleSup">2</span>&#44; respectively&#46; Regarding anthropometric variables&#44; mid-arm circumference&#44; mid-arm muscle circumference&#44; and arm muscle area had a positive correlation with phase angle&#46; In contrast&#44; when analyzing the lipid profile&#44; only HDL was inversely correlated with phase angle&#46; However&#44; in multiple regression models adjusted for age and gender&#44; only mid-arm circumference &#40;<span class="elsevierStyleItalic">p</span>&#8202;&#61;&#8202;0&#46;005&#41;&#44; mid-arm muscle circumference &#40;<span class="elsevierStyleItalic">p</span>&#8202;&#61;&#8202;0&#46;003&#41;&#44; and arm muscle circumference &#40;<span class="elsevierStyleItalic">p</span>&#8202;&#61;&#8202;0&#46;001&#41; were associated with phase angle in hepatitis C virus-infected patients&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS&#58;</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">In conclusion&#44; phase angle is positively correlated with anthropometric measures in our study&#46; However&#44; there is no association between phase angle and lipid profile in these patients&#46; Our results suggest that phase angle is related to lean body mass in patients chronically infected with hepatitis C virus&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "OBJECTIVE&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "METHODS&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "RESULTS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "CONCLUSIONS&#58;"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">Dorna MS collected the data and contributed to the conception and design of the study&#46; Costa NA and Oliveira EP collected the data&#46; Sassaki LY and Romeiro FG contributed to the design of the study and translation of the manuscript into English&#46; Paiva SA performed the statistical analysis&#46; Minicucci MF and Silva GF contributed to the conception and design of the study&#46;</p> <p class="elsevierStyleNotepara" id="cenpara20">No potential conflict of interest was reported&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "t1-cln_68p1555"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">PhA&#58; phase angle&#59; total cholesterol&#58; TC&#59; HDL-cholesterol&#58; HDL&#59; triglycerides&#58; TG&#59; LDL-cholesterol&#58; LDL&#59; BMI&#58; body mass index&#59; MAC&#58; mid-arm circumference&#59; TSF&#58; triceps skinfold&#59; MAMC&#58; mid-arm muscle circumference&#59; AMA&#58; arm muscle area&#46; Data are expressed as the mean &#177; SD&#44; median &#40;lower to upper quartile&#41;&#44; or percentage&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81 &#40;60&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;y&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;8&#177;11&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PhA &#40;&#176;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;5&#177;0&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resistance &#40;Ohms&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">538&#46;4&#177;99&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reactance &#40;Ohms&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;8&#177;11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;6&#177;17&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TG &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">105 &#40;79&#8211;142&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&#46;5&#177;34&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#46;2&#177;29&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;5&#177;4&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MAC &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;3&#177;4&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TSF &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;13&#8211;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MAMC &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;9 &#40;23&#46;7&#8211;28&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AMA &#40;mm<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#46;5 &#40;38&#8211;56&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Demographic&#44; anthropometric&#44; and laboratory data from 135 patients with HCV&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "t2-cln_68p1555"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Total cholesterol&#58; TC&#59; HDL-cholesterol&#58; HDL&#59; triglycerides&#58; TG&#59; LDL-cholesterol&#58; LDL&#59; BMI&#58; body mass index&#59; MAC&#58; mid-arm circumference&#59; TSF&#58; triceps skinfold&#59; MAMC&#58; mid-arm muscle circumference&#59; AMA&#58; arm muscle area&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Coefficient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Standard Error&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;189&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;075&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;0002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;899&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TG &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;212&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0208&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;079&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MAC &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0140&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TSF &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0062&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MAMC &#40;cm<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0564&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0184&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="justify" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AMA &#40;mm<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0145&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Multiple linear regression models for phase angle prediction&#44; adjusted for gender and age&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:28 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eradication of hepatitic C virus by interferon improves whole-body insulin resistance and hyperinsulinaemia in patients with chronic hepatitis C"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              Y Kawaguchi \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Mizuta \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              N Oza \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              H Takahashi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              K Ario \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              T Yoshimura \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Liver Inter"
                        "fecha" => "2009"
                        "volumen" => "29"
                        "numero" => "6"
                        "paginaInicial" => "871"
                        "paginaFinal" => "877"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of piginterferon alpha and ribavirin treatment on lipid profiles and insulin resistance in hepatitis C virus&#47;HIV-coinfected persons&#58; The AIDS clinical trials group A5178 study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              AA Butt \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Umbleja \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JW Andersen \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              KE Sherman \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              TR Chung \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              ACTG A5178 Study Team \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "CID"
                        "fecha" => "2012"
                        "volumen" => "55"
                        "numero" => "5"
                        "paginaInicial" => "631"
                        "paginaFinal" => "638"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversal hypolipidemia in chronic hepatitis C patients after successful antiviral therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              YH Kuo \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              TW Chuang \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CH Hung \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CH Cheng \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JH Wang \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              TH Hu \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0929-6646(11)60054-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Formos Med Assoc"
                        "fecha" => "2012"
                        "volumen" => "110"
                        "numero" => "6"
                        "paginaInicial" => "363"
                        "paginaFinal" => "371"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21741004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatitis C virus infection and its clearance alter circulating lipids&#58; implications for long term follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              KE Corey \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              E Kane \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Munroe \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              LL Barlow \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              H Zheng \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RT Chung \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.23219"
                      "Revista" => array:8 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "2009"
                        "volumen" => "50"
                        "numero" => "4"
                        "paginaInicial" => "1030"
                        "paginaFinal" => "1037"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19787818"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0885392418304688"
                          "estado" => "S300"
                          "issn" => "08853924"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of nutritional status and diagnosis of malnutrition in patients with liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              B Campillo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "V RPreedy, RLakshman, RSrirajaskanthan, R RWatson"
                        "titulo" => "Nutrition&#44; Diet Therapy and The Liver"
                        "paginaInicial" => "33"
                        "paginaFinal" => "46"
                        "edicion" => "First Edition"
                        "serieFecha" => "2010"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Norms and correlates of bioimpedance phase angle in healthy human subjects&#44; hospitalized patients&#44; and patients with liver cirrhosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              O Selberg \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Selberg \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00421-001-0570-4"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Appl Physiol"
                        "fecha" => "2002"
                        "volumen" => "86"
                        "numero" => "6"
                        "paginaInicial" => "509"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11944099"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bioelectrical phase angle and impedance vector analysis- clinical relevance and applicability of impedance parameters"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              K Norman \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              N Stob&#228;us \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Pirlich \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Bosy-Whestphal \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clnu.2012.05.008"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Nutr"
                        "fecha" => "2012"
                        "volumen" => "31"
                        "numero" => "6"
                        "paginaInicial" => "854"
                        "paginaFinal" => "861"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22698802"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic significance of bioelectrical phase angle in advanced c&#226;ncer&#58; preliminar observations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              L Santarpia \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Marra \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Montagnese \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              L Alfonsi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              F Pasanisi \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              F Contaldo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nut.2009.01.015"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nutrition"
                        "fecha" => "2009"
                        "volumen" => "25"
                        "numero" => "9"
                        "paginaInicial" => "930"
                        "paginaFinal" => "931"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19500944"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bioelectrical impedance analysis in clinical practice&#58; a new perspective on its use beyond body composition equations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              MC Barbosa-Silva \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AJ Barros \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.mco.0000165011.69943.39"
                      "Revista" => array:7 [
                        "tituloSerie" => "Curr Opin Clin Nutr Metab Care"
                        "fecha" => "2005"
                        "volumen" => "8"
                        "numero" => "3"
                        "paginaInicial" => "311"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15809535"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low phase angle determined by bioelectrical impedance analysis is associated with malnutrition and nutritional risk at hospital admission"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              UG Kyle \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              L Genton \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Pichard \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Nutr"
                        "fecha" => "2013"
                        "volumen" => "32"
                        "numero" => "2"
                        "paginaInicial" => "194"
                        "paginaFinal" => "199"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Espen Guidelines on Enteral Nutrition&#58; Liver Disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              M Plauth \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              E Cabr&#233; \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              O Riggio \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              M Assis-Camilo \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              M Pirlich \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              J Kondrup \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clnu.2006.01.018"
                      "Revista" => array:8 [
                        "tituloSerie" => "Clin Nutr"
                        "fecha" => "2006"
                        "volumen" => "25"
                        "numero" => "2"
                        "paginaInicial" => "285"
                        "paginaFinal" => "294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16707194"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022399918307050"
                          "estado" => "S300"
                          "issn" => "00223999"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bioelectrical impedance analysis in clinical practice&#58;implications for hepatitis C therapy BIA and hepatitis C"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              A Kahraman \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              J Hilsenbeck \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Nyga \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Ertle \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Wree \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              M Plauth \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Virol J"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "numero" => "7"
                        "paginaInicial" => "191"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity&#58;preventing and managing the global epidemic"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              World Health Organization \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1997"
                        "editorial" => "World Health Organization"
                        "editorialLocalizacion" => "Geneva"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circumferences"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              CW Callaway \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              WC Chumlea \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Bouchard \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JH Himes \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              TG Lohman \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AD Martin \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "T GLohman, A FRoche, RMartorell"
                        "titulo" => "Anthropometric standardizing reference manual"
                        "paginaInicial" => "39"
                        "paginaFinal" => "54"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skinfold thicknesses and measurements technique"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              GG Harrison \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              EK Buskirk \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JEL Carter \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JFE Ohmston \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              TG Lohman \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              ML Pollock \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "T GLohman, A FRoche, RMartorell"
                        "titulo" => "Anthropometric standardizing reference manual"
                        "paginaInicial" => "55"
                        "paginaFinal" => "80"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anthropometric standards for the assessment of growth and nutritional status"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              AR Frisancho \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:5 [
                        "fecha" => "1990"
                        "paginaInicial" => "48"
                        "paginaFinal" => "53"
                        "editorial" => "The University of Michigan Press"
                        "editorialLocalizacion" => "Michigan"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Can phase angle determined by bioelectrical impedance analysis assess nutritional risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              UG Kyle \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              EP Soundar \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              L Genton \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Pichard \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clnu.2012.04.002"
                      "Revista" => array:7 [
                        "tituloSerie" => "A comparison between healthy and hospitalized subjects&#46; Clin Nutr"
                        "fecha" => "2012"
                        "volumen" => "31"
                        "numero" => "6"
                        "paginaInicial" => "875"
                        "paginaFinal" => "881"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22560739"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The phase angle and mass body cell as markers of nutritional status in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              CM Oliveira \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Kubrusly \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              RS Mota \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CA Silva \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              G Choukroun \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              VN Oliveira \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.jrn.2010.01.008"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Ren Nutr"
                        "fecha" => "2010"
                        "volumen" => "20"
                        "numero" => "5"
                        "paginaInicial" => "314"
                        "paginaFinal" => "320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20303790"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is bioelectrical impedance vector analysis of value in the elderly with malnutrition and impaired functionality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              K Norman \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Smoliner \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              L Valentini \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              H Lochs \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              M Pirlich \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nut.2007.05.007"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nutrition"
                        "fecha" => "2007"
                        "volumen" => "23"
                        "numero" => "7-8"
                        "paginaInicial" => "564"
                        "paginaFinal" => "569"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17616343"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disease-related malnutrition but not underweight by BMI is reflected by disturbed electric tissue properties in the bioelectrical impedance vector analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              K Norman \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Smoliner \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Kilbert \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              L Valentini \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              H Lochs \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              M Pirlich \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1017/S0007114508911545"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Nutr"
                        "fecha" => "2008"
                        "volumen" => "100"
                        "numero" => "3"
                        "paginaInicial" => "590"
                        "paginaFinal" => "595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18234142"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in bioimpedance analysis after stable refeeding of undernourished anorexic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              L Scalfi \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Marra \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Caldara \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              E Silvestri \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              F Contaldo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.ijo.0800780"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Obes Relat Metab Disord"
                        "fecha" => "1999"
                        "volumen" => "23"
                        "numero" => "2"
                        "paginaInicial" => "133"
                        "paginaFinal" => "137"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10078846"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nutritional and prognostic correlates of bioimpedance indexes in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              Q Maggiore \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Nigrelli \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Ciccarelli \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Grimaldi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              GA Rossi \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              C Michelassi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.1996.535"
                      "Revista" => array:7 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1996"
                        "volumen" => "50"
                        "numero" => "6"
                        "paginaInicial" => "2103"
                        "paginaFinal" => "2108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8943496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between bioelectrical impedance phase angle and subjective global assessment in advanced colorectal cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              D Gupta \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CG Lis \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SL Dahlk \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J King \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              PG Vashi \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              J Grutsch \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nutr J"
                        "fecha" => "2008"
                        "volumen" => "30"
                        "numero" => "7"
                        "paginaInicial" => "19"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion&#58; a model of viral-related steatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              G Perlemuter \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Sabile \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              P Letteron \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              G Voga \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Topillo \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              Y Chr&#233;tien \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1096/fj.01-0396com"
                      "Revista" => array:7 [
                        "tituloSerie" => "FASEB J"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "numero" => "2"
                        "paginaInicial" => "185"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11818366"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic profiles in patients with chronic hepatitis C&#58; a case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              CS Hsu \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CJ Liu \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CH Liu \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CL Chen \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MY Lai \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              PJ Chen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12072-008-9064-3"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hepatol Int"
                        "fecha" => "2008"
                        "volumen" => "2"
                        "numero" => "2"
                        "paginaInicial" => "250"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19669312"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between beta-lipoprotein levels and outcome of hepatitis C treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              K Gopal \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              TC Johnson \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Gopal \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Wasfish \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              CT Bang \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              P Suwandhi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.21261"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "2006"
                        "volumen" => "44"
                        "numero" => "2"
                        "paginaInicial" => "335"
                        "paginaFinal" => "340"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16871569"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversal of hypolipidemia in chronic hepatitis C patients after successful antiviral therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              YH Kuo \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              TW Chuang \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CH Hung \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CH Chen \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JH Wang \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              TH Hu \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0929-6646(11)60054-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Formos Med Assoc"
                        "fecha" => "2011"
                        "volumen" => "110"
                        "numero" => "6"
                        "paginaInicial" => "363"
                        "paginaFinal" => "371"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21741004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of low- and very-low-density hepatitis C virus RNA-containing particles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              P Andr&#233; \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              F Komurian-Pradel \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Deforges \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              M Perret \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JL Berland \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              M Sodoyer \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/jvi.76.14.6919-6928.2002"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Virol"
                        "fecha" => "2002"
                        "volumen" => "76"
                        "numero" => "14"
                        "paginaInicial" => "6919"
                        "paginaFinal" => "6928"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12072493"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/0000006800000012/v1_202212011241/S1807593222020452/v1_202212011241/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006800000012/v1_202212011241/S1807593222020452/v1_202212011241/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020452?idApp=UINPBA00004N"
]

Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2013(12)13

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	4	2	6
2024 October	21	28	49
2024 September	24	18	42
2024 August	24	16	40
2024 July	24	17	41
2024 June	31	19	50
2024 May	39	15	54
2024 April	48	9	57
2024 March	41	11	52
2024 February	66	18	84
2024 January	19	13	32
2023 December	15	15	30
2023 November	18	21	39
2023 October	13	17	30
2023 September	17	20	37
2023 August	11	8	19
2023 July	19	17	36
2023 June	14	14	28
2023 May	39	1	40
2023 April	33	2	35
2023 March	22	4	26
2023 February	19	2	21
2023 January	6	2	8
2022 December	9	1	10

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter