Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2

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(B) Chromatograms of exon 1 of the SDHD gene showing the wild type and the heterozygote form of the G12S (GGT12AGT) polymorphism." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nikoletta Lendvai, Miklos Tóth, Zsuzsanna Valkusz, Gabriella Bekő, Nikolette Szücs, Éva Csajbók, Péter Igaz, Balázs Kriszt, Balázs Kovács, Károly Rácz, Attila Patócs" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Nikoletta" "apellidos" => "Lendvai" ] 1 => array:2 [ "nombre" => "Miklos" "apellidos" => "Tóth" ] 2 => array:2 [ "nombre" => "Zsuzsanna" "apellidos" => "Valkusz" ] 3 => array:2 [ "nombre" => "Gabriella" "apellidos" => "Bekő" ] 4 => array:2 [ "nombre" => "Nikolette" "apellidos" => "Szücs" ] 5 => array:2 [ "nombre" => "Éva" "apellidos" => "Csajbók" ] 6 => array:2 [ "nombre" => "Péter" "apellidos" => "Igaz" ] 7 => array:2 [ "nombre" => "Balázs" "apellidos" => "Kriszt" ] 8 => array:2 [ "nombre" => "Balázs" "apellidos" => "Kovács" ] 9 => array:2 [ "nombre" => "Károly" "apellidos" => "Rácz" ] 10 => array:2 [ "nombre" => "Attila" "apellidos" => "Patócs" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222024012?idApp=UINPBA00004N" "url" => "/18075932/00000067000000S1/v1_202212010649/S1807593222024012/v1_202212010649/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222023997" "issn" => "18075932" "doi" => "10.6061/clinics/2012(Sup01)13" "estado" => "S300" "fechaPublicacion" => "2012-04-01" "aid" => "2399" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "rev" "cita" => "Clinics. 2012;67 Supl 1:69-75" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "REVIEW" "titulo" => "Genotype-phenotype correlation in multiple endocrine neoplasia type 2" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "69" "paginaFinal" => "75" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 194 "Ancho" => 425 "Tamanyo" => 14300 ] ] "descripcion" => array:1 [ "en" => "Germline mutations in the RET proto-oncogene associated with MEN2 and FMTC. Numbers indicate the mutated codons of the RET gene." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Friedhelm Raue, Karin Frank-Raue" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Friedhelm" "apellidos" => "Raue" ] 1 => array:2 [ "nombre" => "Karin" "apellidos" => "Frank-Raue" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222023997?idApp=UINPBA00004N" "url" => "/18075932/00000067000000S1/v1_202212010649/S1807593222023997/v1_202212010649/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "REVIEW" "titulo" => "Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "77" "paginaFinal" => "84" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Simona M. Wagner, ShuJun Zhu, Adrian C. Nicolescu, Lois M Mulligan" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Simona M." "apellidos" => "Wagner" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "∗" "identificador" => "fn1" ] ] ] 1 => array:3 [ "nombre" => "ShuJun" "apellidos" => "Zhu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "∗" "identificador" => "fn1" ] ] ] 2 => array:2 [ "nombre" => "Adrian C." "apellidos" => "Nicolescu" ] 3 => array:4 [ "nombre" => "Lois M" "apellidos" => "Mulligan" "email" => array:1 [ 0 => "mulligal@queensu.ca" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Pathology & Molecular Medicine, Queen′s University, Kingston, ON, Canada." "identificador" => "aff1" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 1 613 533 6000 ext.77475" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 480 "Ancho" => 559 "Tamanyo" => 32125 ] ] "descripcion" => array:1 [ "en" => "The RET receptor: structure, activation, and oncogenic mutations. (A) Schematic diagram depicting RET tyrosine kinase receptor domains and the location of recurrent oncogenic mutations. The RET protein has a large extracellular domain containing a cysteine-rich region and a series of cadherin homology domains, a transmembrane domain, and an intracellular tyrosine kinase domain. The positions of the most common mutations found in patients with multiple endocrine neoplasia type 2 (MEN 2) are shown. (B) Mechanism of RET activation. Wild-type RET activation requires the dimerization of RET, mediated through formation of a multicomponent complex. RET is activated by binding both a soluble ligand (glial cell-line-derived neurotrophic factor; GDNF) and a non-signaling extracellular co-receptor (GDNF family receptor; GFRα). Upon activation of RET, phosphorylation of multiple intracellular tyrosines leads to stimulation of downstream signaling pathways." ] ] ] "textoCompleto" => "INTRODUCTIONMultiple endocrine neoplasia type 2 (MEN 2) is an inherited cancer syndrome, characterized by medullary thyroid carcinoma (MTC). The disease has three clinically defined subtypes, as described elsewhere in this volume. Briefly, familial MTC (FMTC), considered the least aggressive form of MEN 2, exhibits MTC without additional tumors or phenotypes, and frequently shows later onset than other disease subtypes. MEN 2A is characterized by MTC with pheochromocytoma, which occurs in approximately 50% of cases, and parathyroid hyperplasia or adenoma in 10–35%. Finally, MEN 2B is also characterized by MTC and pheochromocytoma, but parathyroid hyperplasia is rare. This is the most aggressive subtype, with earliest onset of disease and metastasis, and poorest prognosis. In MEN 2B, MTC has been documented in patients as young as 2 months (<a class="elsevierStyleCrossRef" href="#bib1">1</a>). In addition, patients with MEN 2B frequently present with other non-tumor features including ganglioneuromatosis of the mouth and gut, corneal nerve thickening, delayed puberty, and a marfanoid habitus (<a class="elsevierStyleCrossRef" href="#bib2">2</a>),(<a class="elsevierStyleCrossRef" href="#bib3">3</a>).MEN 2 is dominantly inherited, and its genetic cause, mutations of the REarranged during Transfection (RET) proto-oncogene, was first recognized nearly 20 years ago (<a class="elsevierStyleCrossRefs" href="#bib4">4–6</a>). Since then, the range of mutations identified, their potential for predicting clinical course, and the underlying functional effects have been explored. Detection of RET mutations in MEN 2 represents a paradigm for genetically guided patient management, and genotype–phenotype correlations in this disease now inform recommended interventions, patient and family screening, and long-term follow-up (<a class="elsevierStyleCrossRef" href="#bib7">7</a>),(<a class="elsevierStyleCrossRef" href="#bib8">8</a>). Functional characterization of these mutations also has the potential to define optimal therapeutic regimens, and may identify additional phenotypic implications that have not been broadly recognized. Here, we discuss our current understanding of the molecular mechanisms for the more common RET mutations and their potential significance.RET RECEPTORThe RET proto-oncogene encodes a receptor tyrosine kinase that is required for the development of neural-crest-derived cells, the urogenital system, and the central and peripheral nervous systems, notably the enteric nervous system (<a class="elsevierStyleCrossRef" href="#bib9">9</a>),(<a class="elsevierStyleCrossRef" href="#bib10">10</a>). The RET protein has a large extracellular domain containing a cysteine-rich region and a series of cadherin homology domains, a transmembrane domain, and an intracellular tyrosine kinase domain, required for RET phosphorylation and downstream signaling (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>) (<a class="elsevierStyleCrossRef" href="#bib11">11</a>),(<a class="elsevierStyleCrossRef" href="#bib12">12</a>). The RET kinase is structurally similar to other tyrosine kinases, sharing many conserved functional motifs and regulatory residues that have been shown to have importance for kinase enzyme function (<a class="elsevierStyleCrossRef" href="#bib13">13</a>). RET is activated by binding of a multi-protein ligand complex. RET binds a soluble ligand of the glial cell-line-derived neurotrophic factor (GDNF) family but also requires a co-receptor of the GDNF family receptors α (GFRα), which is tethered to the cell membrane via glycosylphosphatidylinositol linkage (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1B</a>) (<a class="elsevierStyleCrossRef" href="#bib14">14</a>),(<a class="elsevierStyleCrossRef" href="#bib15">15</a>). Initially, GDNF binds to GFRα, and these complexes are then able to recruit RET to form heterohexamers that are concentrated in regions of the cell membrane called lipid rafts (<a class="elsevierStyleCrossRef" href="#bib14">14</a>),(<a class="elsevierStyleCrossRef" href="#bib16">16</a>). These are membrane domains enriched in glycosylphosphatidylinositol-linked proteins and signaling molecules that provide a platform not only for enhanced cell signaling, but also for regulation of receptor kinase activity and downregulation (<a class="elsevierStyleCrossRef" href="#bib17">17</a>). Activation of RET leads to stimulation of multiple downstream pathways, including mitogen-activated protein kinase and extracellular signal-regulated kinase, phosphoinositide 3-kinase and protein kinase B, signal transducer and activator of transcription 3, proto-oncogene tyrosine-protein kinase Src1, and focal adhesion kinase (<a class="elsevierStyleCrossRef" href="#bib18">18</a>),(<a class="elsevierStyleCrossRef" href="#bib19">19</a>), that promote cell growth, proliferation, survival, and/or differentiation.<elsevierMultimedia ident="fig1"></elsevierMultimedia>THE RET PROTO-ONCOGENE IN MEN 2MEN 2 is associated with point mutations of RET, predictably leading to its activation in the absence of ligands and co-receptors. Mutations are primarily amino acid substitutions affecting a very small number of RET codons in either the extracellular domain or within the kinase domain (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>); <a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>. Mutations are dominant, requiring only a single mutant allele to confer the disease phenotype. Summaries of MEN 2 RET mutation occurrence are well reviewed elsewhere (<a class="elsevierStyleCrossRefs" href="#bib20">20–23</a>) or are available online (<a href="http://www.arup.utah.edu/database/MEN2/MEN2_welcome.php">http://www.arup.utah.edu/database/MEN2/MEN2_welcome.php</a>). Together, these data suggest strong overall themes as to functional effects of these mutations, but also as to their clinical significance.<elsevierMultimedia ident="tbl1"></elsevierMultimedia>Strong associations of disease subtype, and also specific disease phenotypes, with individual RET mutations have made it possible to stratify risk of MEN 2 by genotype (<a class="elsevierStyleCrossRef" href="#bib7">7</a>),(<a class="elsevierStyleCrossRef" href="#bib8">8</a>). The management guidelines of the American Thyroid Association (<a class="elsevierStyleCrossRef" href="#bib8">8</a>) base the recommendations for initial diagnosis, therapeutic intervention, and long-term follow-up on patient genotype and the current understanding of the natural history of the disease associated with each RET mutation. Mutations of cysteine residues (primarily cysteines 609, 611, 618, 620, 630, and 634) in the RET extracellular domain account for the majority of MEN 2A cases, and are also common in patients with FMTC. Intracellular kinase domain mutations are mainly associated with FMTC and MEN 2B. Mutations in the intracellular codons 768, 790, 791, 804, and 891 underlie FMTC, and occur less commonly in patients with MEN 2A (<a class="elsevierStyleCrossRef" href="#bib20">20</a>),(<a class="elsevierStyleCrossRef" href="#bib24">24</a>), while specific mutations of codon 918 (M918T) or 883 (A883F) account for the vast majority of MEN 2B cases, and are exclusive to the subtype (<a class="elsevierStyleCrossRef" href="#bib3">3</a>),(<a class="elsevierStyleCrossRef" href="#bib25">25</a>). In addition to association with disease subtype, significant correlations of specific mutations with disease features are reported. For example, RET codon 634 mutations carry a greater patient risk for pheochromocytoma and parathyroid hyperplasia (<a class="elsevierStyleCrossRef" href="#bib4">4</a>),(<a class="elsevierStyleCrossRefs" href="#bib26">26–28</a>), and are associated with a higher frequency of detection of MTC at the time of early thyroidectomy (<a class="elsevierStyleCrossRef" href="#bib29">29</a>). Variation in clinical presentation has even been observed with different codon 634 substitutions. The specific substitution of an arginine at codon 634 (C634R) is strongly associated with increased risk of parathyroid hyperplasia (<a class="elsevierStyleCrossRef" href="#bib4">4</a>),(<a class="elsevierStyleCrossRefs" href="#bib26">26–28</a>), increased frequency of distant metastases, earlier onset of both lymph node and distant metastases, and bilaterality of pheochromocytoma (<a class="elsevierStyleCrossRef" href="#bib30">30</a>),(<a class="elsevierStyleCrossRef" href="#bib31">31</a>).MOLECULAR MECHANISMS OF RET MUTATIONSEvidence-based assessment of MEN 2 genotypic data demonstrate that not all RET mutations have equivalent clinical significance, although all reported mutations are thought to lead to ligand-independent constitutive activation of the RET receptor, autophosphorylation of RET, and aberrant stimulation of downstream signaling pathways. It follows that the molecular mechanisms of mutations associated with these different phenotypes may also be distinct and that these mechanisms may provide clues to disease origin and, potentially, treatment for patients with these mutations. Here, we discuss some of the current understanding of the mechanisms of RET dysfunction seen in MEN 2, and explore the potential implications of these mechanisms.RET Extracellular Domain Cysteine ResiduesThe most frequently identified RET mutations in MEN 2 affect cysteines in the extracellular cysteine-rich region (primarily residues between Cys515 and Cys634) (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>); <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>. In the normal protein, intramolecular cysteine–cysteine disulfide bonds contribute to the tertiary structure of the RET extracellular domain. Correct positioning of residues in this region is critical to interactions with GDNF–GFRα ligand complexes (<a class="elsevierStyleCrossRef" href="#bib14">14</a>),(<a class="elsevierStyleCrossRef" href="#bib15">15</a>),(<a class="elsevierStyleCrossRef" href="#bib32">32</a>). Amino acid substitutions, resulting in replacement of a normal cysteine with any amino acid, lead to loss of intramolecular bonds and to an unpaired cysteine that is available for intermolecular interactions with other mutant RET proteins (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2A</a>) (<a class="elsevierStyleCrossRefs" href="#bib33">33–35</a>). These mutant RET dimers are constitutively active in the absence of ligands. Furthermore, mutant dimers are not recruited to lipid rafts through GFRα interactions, and may be activated in other membrane compartments, which can affect the nature and intensity of the resultant downstream signals (<a class="elsevierStyleCrossRef" href="#bib36">36</a>),(<a class="elsevierStyleCrossRef" href="#bib37">37</a>). Downstream signaling regulation, via interactions with ubiquitin ligases such as CasitasB-lineage lymphoma proto-oncogene (CBL) (<a class="elsevierStyleCrossRef" href="#bib38">38</a>), or with cellular phosphatases such as SHP1 and SHP2 (<a class="elsevierStyleCrossRef" href="#bib39">39</a>),(<a class="elsevierStyleCrossRef" href="#bib40">40</a>) that are involved in limiting or terminating signals, differ from that of the raft-associated wild-type receptor, enhancing the effect of the oncogenic mutation.<elsevierMultimedia ident="fig2"></elsevierMultimedia>Although the molecular mechanisms of activation are similar, cysteine RET mutations also vary in impact. In general, mutations located closer to the RET transmembrane domain have greater transforming ability and are linked to increased risks of more aggressive MEN 2 disease (<a class="elsevierStyleCrossRef" href="#bib41">41</a>) (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>). Codon 634 mutations confer the greatest degree of RET activation, with higher levels of autophosphorylation and transforming ability than the other cysteine mutations, and are linked to broader phenotypes and more severe disease, as described above. Interestingly, mutations of other cysteine residues are believed to affect the efficiency of RET protein folding and maturation, and to impair transport to the cell membrane, resulting in decreased levels of cell surface protein and weaker signaling capability (<a class="elsevierStyleCrossRefs" href="#bib33">33–35,42,43</a>). In fact, a subset of RET cysteine mutations, sometimes referred to as Janus mutations, can lead to a partial loss-of-function phenotype, as well as to oncogenic effects. These mutations, generally affecting codons 609, 611, 618 or 620, are thought to confer cell-type-specific decreases in functional protein on the cell surface. Inactivating mutations of RET can lead to the congenital abnormality Hirschsprung disease, which is characterized by the absence of the enteric neurons from the distal colon (<a class="elsevierStyleCrossRef" href="#bib44">44</a>). Janus mutations have been linked to an insufficiency of mature RET protein in the gut, resulting in the Hirschsprung phenotype, yet at the same time, risks remain high for MEN 2 phenotypes, as sufficient mature protein is expressed in the thyroid for development of MTC (<a class="elsevierStyleCrossRefs" href="#bib45">45–47</a>).RET Intracellular Domain MutationsIntracellular RET kinase mutations fall into two groups: high-penetrance mutations causing MEN 2B, and less aggressive mutations that lead to FMTC or, more rarely, MEN 2A (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>). These RET mutations fall within the N-terminal and C-terminal lobes of the kinase (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>). Although the mutations are spread out along the linear protein sequence (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>), they appear to cluster on either the ATP-binding face or substrate-binding/autoinhibitory face of the protein tertiary structure, suggesting some common themes in their functional effects (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>); <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>. The precise mechanisms by which these intracellular mutations activate RET are various, but it is suggested that they all do so through destabilizing the inactive form of RET, and shifting the equilibrium of RET receptors towards the active state (<a class="elsevierStyleCrossRef" href="#bib48">48</a>).<elsevierMultimedia ident="fig3"></elsevierMultimedia>MEN 2B MutationsOver 95% of MEN 2B cases are associated with the same methionine to threonine change at codon 918 (M918T) in the RET kinase domain (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>). Structurally, this residue lies in the substrate-binding pocket of the kinase, and the M918T mutation appears to increase RET–ATP binding affinity and the stability of the active ATP-bound form, effectively making RET more active, more of the time (<a class="elsevierStyleCrossRefs" href="#bib48">48–51</a>). The M918T mutation appears to increase the stability of monomeric active forms of RET, but activation of these mutants can also be further enhanced by binding of GDNF–GFRα complexes, suggesting that these mutant RET forms may induce signal transduction from both within and outside the lipid rafts, perhaps via distinct signaling complexes (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2B</a>). As a result, RET downstream signals are enhanced, and activation of targets is increased, notably including upregulation of gene transcripts that contribute to cell proliferation or to metastasis-promoting cell behaviors (<a class="elsevierStyleCrossRef" href="#bib52">52</a>),(<a class="elsevierStyleCrossRef" href="#bib53">53</a>). Although it has been postulated that the M918T mutation alters the preferred substrates of the mutant RET protein with respect to both autophosphorylation of RET tyrosine residues, and phosphorylation of downstream signaling molecules (<a class="elsevierStyleCrossRef" href="#bib54">54</a>),(<a class="elsevierStyleCrossRef" href="#bib55">55</a>), novel downstream targets that cannot also be stimulated at lower levels by other less active RET mutants or by ligand activation of wild-type RET have not been broadly identified (<a class="elsevierStyleCrossRefs" href="#bib48">48–51,53</a>).An intriguing finding has been that activation of M918T RET begins before the receptor arrives at the cell surface, stimulating signaling pathways from the endoplasmic reticulum before the receptor reaches its fully glycosylated mature form (<a class="elsevierStyleCrossRef" href="#bib56">56</a>), which has not been observed for other mutants. RET signaling from intracellular compartments may differ (in intensity or otherwise) from that at the plasma membrane, which has been shown to be the case when wild-type RET is internalized into endosomes following ligand stimulation (<a class="elsevierStyleCrossRef" href="#bib57">57</a>) and for cytosolic RET mutants found in papillary thyroid carcinoma (<a class="elsevierStyleCrossRef" href="#bib37">37</a>).An alanine to phenylalanine substitution at codon 883 (A883F) is the only other recurring MEN 2B mutation (<a class="elsevierStyleCrossRef" href="#bib58">58</a>),(<a class="elsevierStyleCrossRef" href="#bib59">59</a>). Structurally, this residue lies between the activation and catalytic loops of the kinase (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>), and would be predicted to increase the flexibility of these domains, so destabilizing the inactive form of the protein and promoting its activation. Although generally considered a high-risk mutation, some studies suggest that it may have a lesser effect than the M918T mutation (<a class="elsevierStyleCrossRef" href="#bib60">60</a>).A handful of instances of double mutations in MEN 2B have also been reported: V804M/E805K (<a class="elsevierStyleCrossRef" href="#bib51">51</a>), V804M/Y806C (<a class="elsevierStyleCrossRef" href="#bib61">61</a>), and V804M/S904C (<a class="elsevierStyleCrossRef" href="#bib62">62</a>). It appears that the combination of two mild intracellular mutations can cooperate to produce a more severe mutant. Each mutation alone (V804M, E805K, Y806C, S904C) has low or no transforming ability, consistent with the observation that V804M generally leads to FMTC (discussed below), but when coupled together, they exert a synergistic effect on the transforming ability of mutated RET (<a class="elsevierStyleCrossRef" href="#bib51">51</a>),(<a class="elsevierStyleCrossRef" href="#bib63">63</a>).Lower Risk Intracellular Domain MutationsRecurrent mutations in the intracellular codons 768, 790, 791, 804, and 891 are found in patients with FMTC and, less commonly, MEN 2A (<a class="elsevierStyleCrossRef" href="#bib20">20</a>),(<a class="elsevierStyleCrossRef" href="#bib64">64</a>). This group of mutations is the most diverse in functional effects, phenotypic variability, and long-term clinical implications.Mutations of glutamic acid 768 occur almost exclusively in patients with FMTC, whereas leucine 790 mutations have been recognized in both FMTC and MEN 2A families (<a class="elsevierStyleCrossRefs" href="#bib20">20–23</a>). These are considered lower penetrance mutations, associated with later-onset disease, as reflected by evidence-based clinical management recommendations suggesting that delayed prophylactic surgery may be acceptable (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>) (<a class="elsevierStyleCrossRef" href="#bib8">8</a>). The E768 and L790 residues lie close to the ATP binding site (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>) and may alter interactions in this region, and/or increase flexibility of domains, making the transition to an active conformation relatively easy.Mutation of serine 891 to an alanine was initially recognized as an FMTC mutation, but more recently has been linked to MEN 2A features (<a class="elsevierStyleCrossRef" href="#bib65">65</a>). Codon 891 lies in a conserved region of the RET protein, and its mutation appears to alter protein autoinhibition and ATP binding, favoring an active conformation. Interestingly, S891A and Y791F mutations are functionally unique in that they do not require RET dimerization for full activation, and so RET autophosphorylation and downstream signaling are not further enhanced by ligand binding (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2C</a>) (<a class="elsevierStyleCrossRef" href="#bib66">66</a>). As for other RET mutants, this means that RET is not recruited into lipid rafts by GFRα, and hence it is likely that the nature, intensity, and duration of signaling is altered for these mutants (<a class="elsevierStyleCrossRefs" href="#bib36">36–40</a>).The most common of these lower-risk mutations is substitution of valine 804 (<a class="elsevierStyleCrossRef" href="#bib67">67</a>). This residue lies in the sequence linking the N-terminal and C-terminal lobes of the kinase domain, in a conserved region critical for RET–ATP binding, which is required for activation of the kinase. Substitution of valine 804 for a leucine (V804L) or methionine (V804M) changes the conformation of the ATP binding pocket, making it more permissive for binding ATP, and thus enhancing RET activation (<a class="elsevierStyleCrossRef" href="#bib51">51</a>),(<a class="elsevierStyleCrossRef" href="#bib68">68</a>),(<a class="elsevierStyleCrossRef" href="#bib69">69</a>). Residue 804 represents a classical gatekeeper residue (<a class="elsevierStyleCrossRef" href="#bib51">51</a>), positioned so as to regulate access to the ATP-binding site. Competitive binding to this region is the mechanism of action of multikinase inhibitors such as vandetanib, which has recently been approved for treatment of advanced MTC (<a class="elsevierStyleCrossRef" href="#bib70">70</a>). Although vandetanib effectively inhibits wild-type and other mutant RET forms, the V804L or V804M mutations confer resistance to the drug (<a class="elsevierStyleCrossRef" href="#bib48">48</a>),(<a class="elsevierStyleCrossRef" href="#bib68">68</a>). As other kinase inhibitors (such as sorafenib, which is currently under review for managing advanced thyroid carcinoma (<a class="elsevierStyleCrossRef" href="#bib71">71</a>),(<a class="elsevierStyleCrossRef" href="#bib72">72</a>) are not affected by codon 804 mutations (<a class="elsevierStyleCrossRef" href="#bib68">68</a>), RET mutation status can have profound clinical importance for optimizing treatment regimens.The molecular effects of substitution of phenylalanine for tyrosine at codon 791 (Y791F) of RET are not clearly defined. This residue is not a known site of tyrosine phosphorylation (<a class="elsevierStyleCrossRef" href="#bib73">73</a>), so direct protein interactions of RET with other molecules are unlikely to be altered by this mutation. The position of the residue, close to the ATP binding pocket, may enhance ATP access, or may again alter protein flexibility, favoring the active conformation. In vitro, Y791F mutations have been shown to enhance signal transducer and activator of transcription 3 (STAT3) signaling (<a class="elsevierStyleCrossRef" href="#bib74">74</a>). Like S891A mutants, the Y791F form of RET appears to exist as an active monomer as it does not require dimerization to be activated, and ligand binding does not further enhance autophosphorylation or downstream signaling (<a class="elsevierStyleCrossRef" href="#bib66">66</a>). The significance of the Y791F mutation remains somewhat controversial. Reports have identified this mutation, alone or in combination with other mutations, in MEN 2A and FMTC, and in sporadic MTC and pheochromocytoma tumors (<a class="elsevierStyleCrossRef" href="#bib24">24</a>),(<a class="elsevierStyleCrossRef" href="#bib75">75</a>). Co-occurrence of Y791F and codon 634 mutations has been shown to increase the risk of pheochromocytoma in some families (<a class="elsevierStyleCrossRef" href="#bib76">76</a>), whereas other studies have concluded that this mutation is not pathogenic (<a class="elsevierStyleCrossRef" href="#bib77">77</a>). Interestingly, a clue is perhaps provided by studies identifying Y791F and Y791N mutations in patients with Hirschsprung disease (<a class="elsevierStyleCrossRef" href="#bib75">75</a>),(<a class="elsevierStyleCrossRef" href="#bib78">78</a>),(<a class="elsevierStyleCrossRef" href="#bib79">79</a>), possibly suggesting that mutations of tyrosine 791 may act as modifiers of multiple phenotypes.CONCLUSIONS AND PERSPECTIVESThe landscape of MEN 2 disease management has been transformed by the identification and cataloguing of its underlying genetic causes. Mutation genotype has guided the evidence-based diagnosis, prediction, and management of MEN 2 as for few other diseases. However, we are only beginning to reap the benefits of functional characterization of RET mutations. The new crop of anti-RET therapeutics being developed has implications not just for MEN 2, but for thyroid cancer in general, and for other diseases that have recently been linked to RET activity including pancreatic and breast cancers (<a class="elsevierStyleCrossRefs" href="#bib80">80–82</a>). Conversely, mutations or altered expression of RET that result in decreased receptor function have been linked to developmental defects, such as Hirschsprung disease (<a class="elsevierStyleCrossRef" href="#bib44">44</a>) and kidney anomalies (<a class="elsevierStyleCrossRef" href="#bib83">83</a>),(<a class="elsevierStyleCrossRef" href="#bib84">84</a>), and current research also links GDNF and survival of dopaminergic neurons in Parkinson disease (<a class="elsevierStyleCrossRef" href="#bib85">85</a>). Together, these studies clearly indicate that understanding of the normal functions and physiological role of RET are essential in assessing the short-term and long-term benefits and potential harms of novel RET-targeted therapeutics." "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "xpalclavsec1581207" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:2 [ "identificador" => "cesec20" "titulo" => "RET RECEPTOR" ] 3 => array:2 [ "identificador" => "cesec30" "titulo" => "THE RET PROTO-ONCOGENE IN MEN 2" ] 4 => array:3 [ "identificador" => "cesec40" "titulo" => "MOLECULAR MECHANISMS OF RET MUTATIONS" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "cesec50" "titulo" => "RET Extracellular Domain Cysteine Residues" ] 1 => array:2 [ "identificador" => "cesec60" "titulo" => "RET Intracellular Domain Mutations" ] 2 => array:2 [ "identificador" => "cesec70" "titulo" => "MEN 2B Mutations" ] 3 => array:2 [ "identificador" => "cesec80" "titulo" => "Lower Risk Intracellular Domain Mutations" ] ] ] 5 => array:2 [ "identificador" => "cesec90" "titulo" => "CONCLUSIONS AND PERSPECTIVES" ] 6 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1581207" "palabras" => array:3 [ 0 => "RET" 1 => "Multiple Endocrine Neoplasia Type 2" 2 => "Genotype–Phenotype" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:1 [ "resumen" => "Multiple endocrine neoplasia type 2 is an inherited cancer syndrome characterized by tumors of thyroid and adrenal tissues. Germline mutations of the REarranged during Transfection (RET) proto-oncogene, leading to its unregulated activation, are the underlying cause of this disease. Multiple endocrine neoplasia type 2 has been a model in clinical cancer genetics, demonstrating how knowledge of the genetic basis can shape the diagnosis and treatment of the disease. Here, we discuss the nature and effects of the most common recurrent mutations of RET found in multiple endocrine neoplasia type 2. Current understanding of the molecular mechanisms of RET mutations and how they alter the structure and function of the RET protein leading to its aberrant activation, and the effects on RET localization and signaling are described." ] ] "NotaPie" => array:2 [ 0 => array:1 [ "nota" => "Wagner SM prepared the figures and was also responsible for the manuscript writing. Zhu S contributed to the manuscript writing. Nicolescu A prepared the models and figures. Mulligan LM is the senior author who prepared the final manuscript version. Wagner SM and Zhu S contributed equally to the study." ] 1 => array:3 [ "etiqueta" => "∗" "nota" => "contributed equally to the study" "identificador" => "fn1" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 480 "Ancho" => 559 "Tamanyo" => 32125 ] ] "descripcion" => array:1 [ "en" => "The RET receptor: structure, activation, and oncogenic mutations. (A) Schematic diagram depicting RET tyrosine kinase receptor domains and the location of recurrent oncogenic mutations. The RET protein has a large extracellular domain containing a cysteine-rich region and a series of cadherin homology domains, a transmembrane domain, and an intracellular tyrosine kinase domain. The positions of the most common mutations found in patients with multiple endocrine neoplasia type 2 (MEN 2) are shown. (B) Mechanism of RET activation. Wild-type RET activation requires the dimerization of RET, mediated through formation of a multicomponent complex. RET is activated by binding both a soluble ligand (glial cell-line-derived neurotrophic factor; GDNF) and a non-signaling extracellular co-receptor (GDNF family receptor; GFRα). Upon activation of RET, phosphorylation of multiple intracellular tyrosines leads to stimulation of downstream signaling pathways." ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 364 "Ancho" => 661 "Tamanyo" => 36827 ] ] "descripcion" => array:1 [ "en" => "Molecular mechanisms of pathogenic RET activation. Schematic diagrams showing mechanisms of RET activation in the presence of various multiple endocrine neoplasia type 2 (MEN 2) mutations. (A) Substitutions of extracellular cysteines lead to formation of intermolecular disulfide bonds and to constitutive RET dimerization and activation. (B) The MEN 2B mutation, M918T (star) in the kinase domain, leads to a conformational change with multiple effects including an increase in RET kinase activity and activation of receptors in either dimeric or monomeric form. (C) Intracellular kinase domain mutations asterisk implicated in familial medullary thyroid carcinoma (FMTC) (e.g. residues 791 and 891), permit activation of monomeric RET, allowing for a partially active conformation." ] ] 2 => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 381 "Ancho" => 662 "Tamanyo" => 42700 ] ] "descripcion" => array:1 [ "en" => "Structure of the RET tyrosine kinase domain. Ribbon diagrams of the intracellular regions of activated RET, in two orientations, showing the positions of key functional features of the kinase: the ATP binding pocket; the activation or autoinhibitory loop; and the substrate binding pocket. Two orientations of the model, displaying the autoinhibitory/substrate binding face (left) and the ATP-binding face (right), are shown. Amino acid residues that are mutated in patients with multiple endocrine neoplasia type 2 (MEN 2) are represented in the stick form. The three-dimensional representation was based on the crystal structure of the phosphorylated (activated) RET tyrosine kinase domain (residues 709–990)." ] ] 3 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "FMTC, familial medullary thyroid carcinoma; MEN 2, multiple endocrine neoplasia 2; RET, REarranged during Transfection." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col">Mutation location \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Affected RET Codons \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Putative function of thewild-type residue \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Predicted mutation effects \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Phenotype \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Recommendedintervention (<a class="elsevierStyleCrossRef" href="#bib8">8</a>) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Extracellular- cysteine rich domain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">C609C611C618C620C630 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Contributes to tertiary structure of RET through the formation of intramolecular disulfide bonds \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Weakly activating. Alteration in protein folding and maturation.Formation of mutant RET dimers that are constitutively active in the absence of ligands \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">MEN 2A and FMTC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Prophylactic thyroid surgery before the age of 5. Under some conditions may delay beyond 5 years \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">C634 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Role in formation of intramolecular disulfide bonds \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Strongly activating. Ligand-independent dimerization of receptor molecules, enhanced phosphorylation of intracellular substrates. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">MEN 2A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Surgery before age 5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Intracellular tyrosine kinase domain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">L790, Y791 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">In the N-terminal lobe of the RET kinase \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Moderately activating. Affects ATP binding and inter-lobe flexibility. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">MEN 2A and FMTC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">May delay surgery beyond 5 years \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">E768 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">In close proximity with the ATP binding site \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Alters interactions within the region and facilitates the transition to an active conformation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">FMTC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">V804 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">A gatekeeper residue which regulates access to the ATP binding site \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Alters hinge flexibility and positioning of RET helices for catalysis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">FMTC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">S891 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">C-terminal lobe of the kinase, adjacent to the activation loop of the kinase \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Alters activation loop conformation and promotes monomeric RET activation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">MEN 2A and FMTC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">A883 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Situated next to activation loop \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Strongly activating. Local conformational change which destabilizes the inactive form of the protein and promotes its activation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">MEN 2B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">As early as possible (within first year of life) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">M918 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Lies in the substrate-binding pocket of the kinase and plays a role in stabilizing the receptor–ATP complex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Strongly activating. Alters protein conformation and substrate specificity. The mutant can dimerize and become phosphorylated in the absence of ligand stimulation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">MEN 2B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Molecular effects of RET mutations in multiple endocrine neoplasia 2." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:85 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medullary thyroid carcinoma as part of a multiple endocrine neoplasia type 2B syndrome: influence of the stage on the clinical course" "autores" => array:1 [ 0 => 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Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Pathology & Molecular Medicine, Queen′s University, Kingston, ON, Canada.

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            "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Gel electrophoresis of PCR fragments after digestion with <span class="elsevierStyleItalic">Ban</span>I for identification of the G12S polymorphism of the <span class="elsevierStyleItalic">SDHD</span> gene by RFLP &#40;L &#61; DNA ladder&#59; C&#43; &#61; positive control&#59; heterozygote for G12S&#59; C- &#61; negative control&#59; G12 normal&#44; P1&#8211;P5 &#61; patients&#46; &#40;B&#41; Chromatograms of exon 1 of the <span class="elsevierStyleItalic">SDHD</span> gene showing the wild type and the heterozygote form of the G12S &#40;GGT12AGT&#41; polymorphism&#46;</p>"
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      "titulo" => "Genotype-phenotype correlation in multiple endocrine neoplasia type 2"
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    "titulo" => "Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2"
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          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">The RET receptor&#58; structure&#44; activation&#44; and oncogenic mutations&#46; &#40;A&#41; Schematic diagram depicting RET tyrosine kinase receptor domains and the location of recurrent oncogenic mutations&#46; The RET protein has a large extracellular domain containing a cysteine-rich region and a series of cadherin homology domains&#44; a transmembrane domain&#44; and an intracellular tyrosine kinase domain&#46; The positions of the most common mutations found in patients with multiple endocrine neoplasia type 2 &#40;MEN 2&#41; are shown&#46; &#40;B&#41; Mechanism of RET activation&#46; Wild-type RET activation requires the dimerization of RET&#44; mediated through formation of a multicomponent complex&#46; RET is activated by binding both a soluble ligand &#40;glial cell-line-derived neurotrophic factor&#59; GDNF&#41; and a non-signaling extracellular co-receptor &#40;GDNF family receptor&#59; GFR&#945;&#41;&#46; Upon activation of RET&#44; phosphorylation of multiple intracellular tyrosines leads to stimulation of downstream signaling pathways&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Multiple endocrine neoplasia type 2 &#40;MEN 2&#41; is an inherited cancer syndrome&#44; characterized by medullary thyroid carcinoma &#40;MTC&#41;&#46; The disease has three clinically defined subtypes&#44; as described elsewhere in this volume&#46; Briefly&#44; familial MTC &#40;FMTC&#41;&#44; considered the least aggressive form of MEN 2&#44; exhibits MTC without additional tumors or phenotypes&#44; and frequently shows later onset than other disease subtypes&#46; MEN 2A is characterized by MTC with pheochromocytoma&#44; which occurs in approximately 50&#37; of cases&#44; and parathyroid hyperplasia or adenoma in 10&#8211;35&#37;&#46; Finally&#44; MEN 2B is also characterized by MTC and pheochromocytoma&#44; but parathyroid hyperplasia is rare&#46; This is the most aggressive subtype&#44; with earliest onset of disease and metastasis&#44; and poorest prognosis&#46; In MEN 2B&#44; MTC has been documented in patients as young as 2 months &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41;&#46; In addition&#44; patients with MEN 2B frequently present with other non-tumor features including ganglioneuromatosis of the mouth and gut&#44; corneal nerve thickening&#44; delayed puberty&#44; and a marfanoid habitus &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib3">3</a>&#41;&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">MEN 2 is dominantly inherited&#44; and its genetic cause&#44; mutations of the <span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">RE</span>arranged during <span class="elsevierStyleUnderline">T</span>ransfection</span> &#40;<span class="elsevierStyleItalic">RET</span>&#41; proto-oncogene&#44; was first recognized nearly 20 years ago &#40;<a class="elsevierStyleCrossRefs" href="#bib4">4&#8211;6</a>&#41;&#46; Since then&#44; the range of mutations identified&#44; their potential for predicting clinical course&#44; and the underlying functional effects have been explored&#46; Detection of <span class="elsevierStyleItalic">RET</span> mutations in MEN 2 represents a paradigm for genetically guided patient management&#44; and genotype&#8211;phenotype correlations in this disease now inform recommended interventions&#44; patient and family screening&#44; and long-term follow-up &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46; Functional characterization of these mutations also has the potential to define optimal therapeutic regimens&#44; and may identify additional phenotypic implications that have not been broadly recognized&#46; Here&#44; we discuss our current understanding of the molecular mechanisms for the more common <span class="elsevierStyleItalic">RET</span> mutations and their potential significance&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RET RECEPTOR</span><p id="para30" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">RET</span> proto-oncogene encodes a receptor tyrosine kinase that is required for the development of neural-crest-derived cells&#44; the urogenital system&#44; and the central and peripheral nervous systems&#44; notably the enteric nervous system &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib10">10</a>&#41;&#46; The RET protein has a large extracellular domain containing a cysteine-rich region and a series of cadherin homology domains&#44; a transmembrane domain&#44; and an intracellular tyrosine kinase domain&#44; required for RET phosphorylation and downstream signaling &#40;<a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib11">11</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#41;&#46; The RET kinase is structurally similar to other tyrosine kinases&#44; sharing many conserved functional motifs and regulatory residues that have been shown to have importance for kinase enzyme function &#40;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41;&#46; RET is activated by binding of a multi-protein ligand complex&#46; RET binds a soluble ligand of the glial cell-line-derived neurotrophic factor &#40;GDNF&#41; family but also requires a co-receptor of the GDNF family receptors &#945; &#40;GFR&#945;&#41;&#44; which is tethered to the cell membrane via glycosylphosphatidylinositol linkage &#40;<a class="elsevierStyleCrossRef" href="#fig1">Figure 1B</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#46; Initially&#44; GDNF binds to GFR&#945;&#44; and these complexes are then able to recruit RET to form heterohexamers that are concentrated in regions of the cell membrane called lipid rafts &#40;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib16">16</a>&#41;&#46; These are membrane domains enriched in glycosylphosphatidylinositol-linked proteins and signaling molecules that provide a platform not only for enhanced cell signaling&#44; but also for regulation of receptor kinase activity and downregulation &#40;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#41;&#46; Activation of RET leads to stimulation of multiple downstream pathways&#44; including mitogen-activated protein kinase and extracellular signal-regulated kinase&#44; phosphoinositide 3-kinase and protein kinase B&#44; signal transducer and activator of transcription 3&#44; proto-oncogene tyrosine-protein kinase Src1&#44; and focal adhesion kinase &#40;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#41;&#44; that promote cell growth&#44; proliferation&#44; survival&#44; and&#47;or differentiation&#46;</p><elsevierMultimedia ident="fig1"></elsevierMultimedia></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">THE <span class="elsevierStyleItalic">RET</span> PROTO-ONCOGENE IN MEN 2</span><p id="para40" class="elsevierStylePara elsevierViewall">MEN 2 is associated with point mutations of RET&#44; predictably leading to its activation in the absence of ligands and co-receptors&#46; Mutations are primarily amino acid substitutions affecting a very small number of <span class="elsevierStyleItalic">RET</span> codons in either the extracellular domain or within the kinase domain &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#41;&#59; <a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>&#46; Mutations are dominant&#44; requiring only a single mutant allele to confer the disease phenotype&#46; Summaries of MEN 2 <span class="elsevierStyleItalic">RET</span> mutation occurrence are well reviewed elsewhere &#40;<a class="elsevierStyleCrossRefs" href="#bib20">20&#8211;23</a>&#41; or are available online &#40;<a href="http://www.arup.utah.edu/database/MEN2/MEN2_welcome.php">http&#58;&#47;&#47;www&#46;arup&#46;utah&#46;edu&#47;database&#47;MEN2&#47;MEN2&#95;welcome&#46;php</a>&#41;&#46; Together&#44; these data suggest strong overall themes as to functional effects of these mutations&#44; but also as to their clinical significance&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para50" class="elsevierStylePara elsevierViewall">Strong associations of disease subtype&#44; and also specific disease phenotypes&#44; with individual RET mutations have made it possible to stratify risk of MEN 2 by genotype &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46; The management guidelines of the American Thyroid Association &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41; base the recommendations for initial diagnosis&#44; therapeutic intervention&#44; and long-term follow-up on patient genotype and the current understanding of the natural history of the disease associated with each <span class="elsevierStyleItalic">RET</span> mutation&#46; Mutations of cysteine residues &#40;primarily cysteines 609&#44; 611&#44; 618&#44; 620&#44; 630&#44; and 634&#41; in the RET extracellular domain account for the majority of MEN 2A cases&#44; and are also common in patients with FMTC&#46; Intracellular kinase domain mutations are mainly associated with FMTC and MEN 2B&#46; Mutations in the intracellular codons 768&#44; 790&#44; 791&#44; 804&#44; and 891 underlie FMTC&#44; and occur less commonly in patients with MEN 2A &#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#41;&#44; while specific mutations of codon 918 &#40;M918T&#41; or 883 &#40;A883F&#41; account for the vast majority of MEN 2B cases&#44; and are exclusive to the subtype &#40;<a class="elsevierStyleCrossRef" href="#bib3">3</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib25">25</a>&#41;&#46; In addition to association with disease subtype&#44; significant correlations of specific mutations with disease features are reported&#46; For example&#44; RET codon 634 mutations carry a greater patient risk for pheochromocytoma and parathyroid hyperplasia &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRefs" href="#bib26">26&#8211;28</a>&#41;&#44; and are associated with a higher frequency of detection of MTC at the time of early thyroidectomy &#40;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#41;&#46; Variation in clinical presentation has even been observed with different codon 634 substitutions&#46; The specific substitution of an arginine at codon 634 &#40;C634R&#41; is strongly associated with increased risk of parathyroid hyperplasia &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRefs" href="#bib26">26&#8211;28</a>&#41;&#44; increased frequency of distant metastases&#44; earlier onset of both lymph node and distant metastases&#44; and bilaterality of pheochromocytoma &#40;<a class="elsevierStyleCrossRef" href="#bib30">30</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib31">31</a>&#41;&#46;</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">MOLECULAR MECHANISMS OF RET MUTATIONS</span><p id="para60" class="elsevierStylePara elsevierViewall">Evidence-based assessment of MEN 2 genotypic data demonstrate that not all RET mutations have equivalent clinical significance&#44; although all reported mutations are thought to lead to ligand-independent constitutive activation of the RET receptor&#44; autophosphorylation of RET&#44; and aberrant stimulation of downstream signaling pathways&#46; It follows that the molecular mechanisms of mutations associated with these different phenotypes may also be distinct and that these mechanisms may provide clues to disease origin and&#44; potentially&#44; treatment for patients with these mutations&#46; Here&#44; we discuss some of the current understanding of the mechanisms of RET dysfunction seen in MEN 2&#44; and explore the potential implications of these mechanisms&#46;</p><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">RET Extracellular Domain Cysteine Residues</span><p id="para70" class="elsevierStylePara elsevierViewall">The most frequently identified <span class="elsevierStyleItalic">RET</span> mutations in MEN 2 affect cysteines in the extracellular cysteine-rich region &#40;primarily residues between Cys515 and Cys634&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>&#41;&#59; <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#46; In the normal protein&#44; intramolecular cysteine&#8211;cysteine disulfide bonds contribute to the tertiary structure of the RET extracellular domain&#46; Correct positioning of residues in this region is critical to interactions with GDNF&#8211;GFR&#945; ligand complexes &#40;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib32">32</a>&#41;&#46; Amino acid substitutions&#44; resulting in replacement of a normal cysteine with any amino acid&#44; lead to loss of intramolecular bonds and to an unpaired cysteine that is available for intermolecular interactions with other mutant RET proteins &#40;<a class="elsevierStyleCrossRef" href="#fig2">Figure 2A</a>&#41; &#40;<a class="elsevierStyleCrossRefs" href="#bib33">33&#8211;35</a>&#41;&#46; These mutant RET dimers are constitutively active in the absence of ligands&#46; Furthermore&#44; mutant dimers are not recruited to lipid rafts through GFR&#945; interactions&#44; and may be activated in other membrane compartments&#44; which can affect the nature and intensity of the resultant downstream signals &#40;<a class="elsevierStyleCrossRef" href="#bib36">36</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib37">37</a>&#41;&#46; Downstream signaling regulation&#44; via interactions with ubiquitin ligases such as CasitasB-lineage lymphoma proto-oncogene &#40;CBL&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib38">38</a>&#41;&#44; or with cellular phosphatases such as SHP1 and SHP2 &#40;<a class="elsevierStyleCrossRef" href="#bib39">39</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib40">40</a>&#41; that are involved in limiting or terminating signals&#44; differ from that of the raft-associated wild-type receptor&#44; enhancing the effect of the oncogenic mutation&#46;</p><elsevierMultimedia ident="fig2"></elsevierMultimedia><p id="para80" class="elsevierStylePara elsevierViewall">Although the molecular mechanisms of activation are similar&#44; cysteine RET mutations also vary in impact&#46; In general&#44; mutations located closer to the RET transmembrane domain have greater transforming ability and are linked to increased risks of more aggressive MEN 2 disease &#40;<a class="elsevierStyleCrossRef" href="#bib41">41</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#41;&#46; Codon 634 mutations confer the greatest degree of RET activation&#44; with higher levels of autophosphorylation and transforming ability than the other cysteine mutations&#44; and are linked to broader phenotypes and more severe disease&#44; as described above&#46; Interestingly&#44; mutations of other cysteine residues are believed to affect the efficiency of RET protein folding and maturation&#44; and to impair transport to the cell membrane&#44; resulting in decreased levels of cell surface protein and weaker signaling capability &#40;<a class="elsevierStyleCrossRefs" href="#bib33">33&#8211;35&#44;42&#44;43</a>&#41;&#46; In fact&#44; a subset of RET cysteine mutations&#44; sometimes referred to as Janus mutations&#44; can lead to a partial loss-of-function phenotype&#44; as well as to oncogenic effects&#46; These mutations&#44; generally affecting codons 609&#44; 611&#44; 618 or 620&#44; are thought to confer cell-type-specific decreases in functional protein on the cell surface&#46; Inactivating mutations of RET can lead to the congenital abnormality Hirschsprung disease&#44; which is characterized by the absence of the enteric neurons from the distal colon &#40;<a class="elsevierStyleCrossRef" href="#bib44">44</a>&#41;&#46; Janus mutations have been linked to an insufficiency of mature RET protein in the gut&#44; resulting in the Hirschsprung phenotype&#44; yet at the same time&#44; risks remain high for MEN 2 phenotypes&#44; as sufficient mature protein is expressed in the thyroid for development of MTC &#40;<a class="elsevierStyleCrossRefs" href="#bib45">45&#8211;47</a>&#41;&#46;</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">RET Intracellular Domain Mutations</span><p id="para90" class="elsevierStylePara elsevierViewall">Intracellular RET kinase mutations fall into two groups&#58; high-penetrance mutations causing MEN 2B&#44; and less aggressive mutations that lead to FMTC or&#44; more rarely&#44; MEN 2A &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#41;&#46; These RET mutations fall within the N-terminal and C-terminal lobes of the kinase &#40;<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>&#41;&#46; Although the mutations are spread out along the linear protein sequence &#40;<a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>&#41;&#44; they appear to cluster on either the ATP-binding face or substrate-binding&#47;autoinhibitory face of the protein tertiary structure&#44; suggesting some common themes in their functional effects &#40;<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>&#41;&#59; <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#46; The precise mechanisms by which these intracellular mutations activate RET are various&#44; but it is suggested that they all do so through destabilizing the inactive form of RET&#44; and shifting the equilibrium of RET receptors towards the active state &#40;<a class="elsevierStyleCrossRef" href="#bib48">48</a>&#41;&#46;</p><elsevierMultimedia ident="fig3"></elsevierMultimedia></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">MEN 2B Mutations</span><p id="para100" class="elsevierStylePara elsevierViewall">Over 95&#37; of MEN 2B cases are associated with the same methionine to threonine change at codon 918 &#40;M918T&#41; in the RET kinase domain &#40;<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>&#41;&#46; Structurally&#44; this residue lies in the substrate-binding pocket of the kinase&#44; and the M918T mutation appears to increase RET&#8211;ATP binding affinity and the stability of the active ATP-bound form&#44; effectively making RET more active&#44; more of the time &#40;<a class="elsevierStyleCrossRefs" href="#bib48">48&#8211;51</a>&#41;&#46; The M918T mutation appears to increase the stability of monomeric active forms of RET&#44; but activation of these mutants can also be further enhanced by binding of GDNF&#8211;GFR&#945; complexes&#44; suggesting that these mutant RET forms may induce signal transduction from both within and outside the lipid rafts&#44; perhaps via distinct signaling complexes &#40;<a class="elsevierStyleCrossRef" href="#fig2">Figure 2B</a>&#41;&#46; As a result&#44; RET downstream signals are enhanced&#44; and activation of targets is increased&#44; notably including upregulation of gene transcripts that contribute to cell proliferation or to metastasis-promoting cell behaviors &#40;<a class="elsevierStyleCrossRef" href="#bib52">52</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib53">53</a>&#41;&#46; Although it has been postulated that the M918T mutation alters the preferred substrates of the mutant RET protein with respect to both autophosphorylation of RET tyrosine residues&#44; and phosphorylation of downstream signaling molecules &#40;<a class="elsevierStyleCrossRef" href="#bib54">54</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib55">55</a>&#41;&#44; novel downstream targets that cannot also be stimulated at lower levels by other less active RET mutants or by ligand activation of wild-type RET have not been broadly identified &#40;<a class="elsevierStyleCrossRefs" href="#bib48">48&#8211;51&#44;53</a>&#41;&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">An intriguing finding has been that activation of M918T RET begins before the receptor arrives at the cell surface&#44; stimulating signaling pathways from the endoplasmic reticulum before the receptor reaches its fully glycosylated mature form &#40;<a class="elsevierStyleCrossRef" href="#bib56">56</a>&#41;&#44; which has not been observed for other mutants&#46; RET signaling from intracellular compartments may differ &#40;in intensity or otherwise&#41; from that at the plasma membrane&#44; which has been shown to be the case when wild-type RET is internalized into endosomes following ligand stimulation &#40;<a class="elsevierStyleCrossRef" href="#bib57">57</a>&#41; and for cytosolic RET mutants found in papillary thyroid carcinoma &#40;<a class="elsevierStyleCrossRef" href="#bib37">37</a>&#41;&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">An alanine to phenylalanine substitution at codon 883 &#40;A883F&#41; is the only other recurring MEN 2B mutation &#40;<a class="elsevierStyleCrossRef" href="#bib58">58</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib59">59</a>&#41;&#46; Structurally&#44; this residue lies between the activation and catalytic loops of the kinase &#40;<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>&#41;&#44; and would be predicted to increase the flexibility of these domains&#44; so destabilizing the inactive form of the protein and promoting its activation&#46; Although generally considered a high-risk mutation&#44; some studies suggest that it may have a lesser effect than the M918T mutation &#40;<a class="elsevierStyleCrossRef" href="#bib60">60</a>&#41;&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">A handful of instances of double mutations in MEN 2B have also been reported&#58; V804M&#47;E805K &#40;<a class="elsevierStyleCrossRef" href="#bib51">51</a>&#41;&#44; V804M&#47;Y806C &#40;<a class="elsevierStyleCrossRef" href="#bib61">61</a>&#41;&#44; and V804M&#47;S904C &#40;<a class="elsevierStyleCrossRef" href="#bib62">62</a>&#41;&#46; It appears that the combination of two mild intracellular mutations can cooperate to produce a more severe mutant&#46; Each mutation alone &#40;V804M&#44; E805K&#44; Y806C&#44; S904C&#41; has low or no transforming ability&#44; consistent with the observation that V804M generally leads to FMTC &#40;discussed below&#41;&#44; but when coupled together&#44; they exert a synergistic effect on the transforming ability of mutated RET &#40;<a class="elsevierStyleCrossRef" href="#bib51">51</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib63">63</a>&#41;&#46;</p></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Lower Risk Intracellular Domain Mutations</span><p id="para140" class="elsevierStylePara elsevierViewall">Recurrent mutations in the intracellular codons 768&#44; 790&#44; 791&#44; 804&#44; and 891 are found in patients with FMTC and&#44; less commonly&#44; MEN 2A &#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib64">64</a>&#41;&#46; This group of mutations is the most diverse in functional effects&#44; phenotypic variability&#44; and long-term clinical implications&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">Mutations of glutamic acid 768 occur almost exclusively in patients with FMTC&#44; whereas leucine 790 mutations have been recognized in both FMTC and MEN 2A families &#40;<a class="elsevierStyleCrossRefs" href="#bib20">20&#8211;23</a>&#41;&#46; These are considered lower penetrance mutations&#44; associated with later-onset disease&#44; as reflected by evidence-based clinical management recommendations suggesting that delayed prophylactic surgery may be acceptable &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46; The E768 and L790 residues lie close to the ATP binding site &#40;<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>&#41; and may alter interactions in this region&#44; and&#47;or increase flexibility of domains&#44; making the transition to an active conformation relatively easy&#46;</p><p id="para160" class="elsevierStylePara elsevierViewall">Mutation of serine 891 to an alanine was initially recognized as an FMTC mutation&#44; but more recently has been linked to MEN 2A features &#40;<a class="elsevierStyleCrossRef" href="#bib65">65</a>&#41;&#46; Codon 891 lies in a conserved region of the RET protein&#44; and its mutation appears to alter protein autoinhibition and ATP binding&#44; favoring an active conformation&#46; Interestingly&#44; S891A and Y791F mutations are functionally unique in that they do not require RET dimerization for full activation&#44; and so RET autophosphorylation and downstream signaling are not further enhanced by ligand binding &#40;<a class="elsevierStyleCrossRef" href="#fig2">Figure 2C</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib66">66</a>&#41;&#46; As for other RET mutants&#44; this means that RET is not recruited into lipid rafts by GFR&#945;&#44; and hence it is likely that the nature&#44; intensity&#44; and duration of signaling is altered for these mutants &#40;<a class="elsevierStyleCrossRefs" href="#bib36">36&#8211;40</a>&#41;&#46;</p><p id="para170" class="elsevierStylePara elsevierViewall">The most common of these lower-risk mutations is substitution of valine 804 &#40;<a class="elsevierStyleCrossRef" href="#bib67">67</a>&#41;&#46; This residue lies in the sequence linking the N-terminal and C-terminal lobes of the kinase domain&#44; in a conserved region critical for RET&#8211;ATP binding&#44; which is required for activation of the kinase&#46; Substitution of valine 804 for a leucine &#40;V804L&#41; or methionine &#40;V804M&#41; changes the conformation of the ATP binding pocket&#44; making it more permissive for binding ATP&#44; and thus enhancing RET activation &#40;<a class="elsevierStyleCrossRef" href="#bib51">51</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib68">68</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib69">69</a>&#41;&#46; Residue 804 represents a classical gatekeeper residue &#40;<a class="elsevierStyleCrossRef" href="#bib51">51</a>&#41;&#44; positioned so as to regulate access to the ATP-binding site&#46; Competitive binding to this region is the mechanism of action of multikinase inhibitors such as vandetanib&#44; which has recently been approved for treatment of advanced MTC &#40;<a class="elsevierStyleCrossRef" href="#bib70">70</a>&#41;&#46; Although vandetanib effectively inhibits wild-type and other mutant RET forms&#44; the V804L or V804M mutations confer resistance to the drug &#40;<a class="elsevierStyleCrossRef" href="#bib48">48</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib68">68</a>&#41;&#46; As other kinase inhibitors &#40;such as sorafenib&#44; which is currently under review for managing advanced thyroid carcinoma &#40;<a class="elsevierStyleCrossRef" href="#bib71">71</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib72">72</a>&#41; are not affected by codon 804 mutations &#40;<a class="elsevierStyleCrossRef" href="#bib68">68</a>&#41;&#44; <span class="elsevierStyleItalic">RET</span> mutation status can have profound clinical importance for optimizing treatment regimens&#46;</p><p id="para180" class="elsevierStylePara elsevierViewall">The molecular effects of substitution of phenylalanine for tyrosine at codon 791 &#40;Y791F&#41; of RET are not clearly defined&#46; This residue is not a known site of tyrosine phosphorylation &#40;<a class="elsevierStyleCrossRef" href="#bib73">73</a>&#41;&#44; so direct protein interactions of RET with other molecules are unlikely to be altered by this mutation&#46; The position of the residue&#44; close to the ATP binding pocket&#44; may enhance ATP access&#44; or may again alter protein flexibility&#44; favoring the active conformation&#46; <span class="elsevierStyleItalic">In vitro</span>&#44; Y791F mutations have been shown to enhance signal transducer and activator of transcription 3 &#40;STAT3&#41; signaling &#40;<a class="elsevierStyleCrossRef" href="#bib74">74</a>&#41;&#46; Like S891A mutants&#44; the Y791F form of RET appears to exist as an active monomer as it does not require dimerization to be activated&#44; and ligand binding does not further enhance autophosphorylation or downstream signaling &#40;<a class="elsevierStyleCrossRef" href="#bib66">66</a>&#41;&#46; The significance of the Y791F mutation remains somewhat controversial&#46; Reports have identified this mutation&#44; alone or in combination with other mutations&#44; in MEN 2A and FMTC&#44; and in sporadic MTC and pheochromocytoma tumors &#40;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib75">75</a>&#41;&#46; Co-occurrence of Y791F and codon 634 mutations has been shown to increase the risk of pheochromocytoma in some families &#40;<a class="elsevierStyleCrossRef" href="#bib76">76</a>&#41;&#44; whereas other studies have concluded that this mutation is not pathogenic &#40;<a class="elsevierStyleCrossRef" href="#bib77">77</a>&#41;&#46; Interestingly&#44; a clue is perhaps provided by studies identifying Y791F and Y791N mutations in patients with Hirschsprung disease &#40;<a class="elsevierStyleCrossRef" href="#bib75">75</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib78">78</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib79">79</a>&#41;&#44; possibly suggesting that mutations of tyrosine 791 may act as modifiers of multiple phenotypes&#46;</p></span></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">CONCLUSIONS AND PERSPECTIVES</span><p id="para190" class="elsevierStylePara elsevierViewall">The landscape of MEN 2 disease management has been transformed by the identification and cataloguing of its underlying genetic causes&#46; Mutation genotype has guided the evidence-based diagnosis&#44; prediction&#44; and management of MEN 2 as for few other diseases&#46; However&#44; we are only beginning to reap the benefits of functional characterization of <span class="elsevierStyleItalic">RET</span> mutations&#46; The new crop of anti-RET therapeutics being developed has implications not just for MEN 2&#44; but for thyroid cancer in general&#44; and for other diseases that have recently been linked to RET activity including pancreatic and breast cancers &#40;<a class="elsevierStyleCrossRefs" href="#bib80">80&#8211;82</a>&#41;&#46; Conversely&#44; mutations or altered expression of RET that result in decreased receptor function have been linked to developmental defects&#44; such as Hirschsprung disease &#40;<a class="elsevierStyleCrossRef" href="#bib44">44</a>&#41; and kidney anomalies &#40;<a class="elsevierStyleCrossRef" href="#bib83">83</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib84">84</a>&#41;&#44; and current research also links GDNF and survival of dopaminergic neurons in Parkinson disease &#40;<a class="elsevierStyleCrossRef" href="#bib85">85</a>&#41;&#46; Together&#44; these studies clearly indicate that understanding of the normal functions and physiological role of RET are essential in assessing the short-term and long-term benefits and potential harms of novel RET-targeted therapeutics&#46;</p></span></span>"
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          "titulo" => "INTRODUCTION"
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        2 => array:2 [
          "identificador" => "cesec20"
          "titulo" => "RET RECEPTOR"
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        3 => array:2 [
          "identificador" => "cesec30"
          "titulo" => "THE RET PROTO-ONCOGENE IN MEN 2"
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        4 => array:3 [
          "identificador" => "cesec40"
          "titulo" => "MOLECULAR MECHANISMS OF RET MUTATIONS"
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              "titulo" => "RET Extracellular Domain Cysteine Residues"
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            1 => array:2 [
              "identificador" => "cesec60"
              "titulo" => "RET Intracellular Domain Mutations"
            ]
            2 => array:2 [
              "identificador" => "cesec70"
              "titulo" => "MEN 2B Mutations"
            ]
            3 => array:2 [
              "identificador" => "cesec80"
              "titulo" => "Lower Risk Intracellular Domain Mutations"
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          "identificador" => "cesec90"
          "titulo" => "CONCLUSIONS AND PERSPECTIVES"
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          "titulo" => "REFERENCES"
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          "palabras" => array:3 [
            0 => "RET"
            1 => "Multiple Endocrine Neoplasia Type 2"
            2 => "Genotype&#8211;Phenotype"
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        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Multiple endocrine neoplasia type 2 is an inherited cancer syndrome characterized by tumors of thyroid and adrenal tissues&#46; Germline mutations of the <span class="elsevierStyleItalic">REarranged during Transfection</span> &#40;RET&#41; proto-oncogene&#44; leading to its unregulated activation&#44; are the underlying cause of this disease&#46; Multiple endocrine neoplasia type 2 has been a model in clinical cancer genetics&#44; demonstrating how knowledge of the genetic basis can shape the diagnosis and treatment of the disease&#46; Here&#44; we discuss the nature and effects of the most common recurrent mutations of <span class="elsevierStyleItalic">RET</span> found in multiple endocrine neoplasia type 2&#46; Current understanding of the molecular mechanisms of <span class="elsevierStyleItalic">RET</span> mutations and how they alter the structure and function of the RET protein leading to its aberrant activation&#44; and the effects on <span class="elsevierStyleItalic">RET</span> localization and signaling are described&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">Wagner SM prepared the figures and was also responsible for the manuscript writing&#46; Zhu S contributed to the manuscript writing&#46; Nicolescu A prepared the models and figures&#46; Mulligan LM is the senior author who prepared the final manuscript version&#46; Wagner SM and Zhu S contributed equally to the study&#46;</p>"
      ]
      1 => array:3 [
        "etiqueta" => "&#8727;"
        "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">contributed equally to the study</p>"
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      0 => array:7 [
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        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">The RET receptor&#58; structure&#44; activation&#44; and oncogenic mutations&#46; &#40;A&#41; Schematic diagram depicting RET tyrosine kinase receptor domains and the location of recurrent oncogenic mutations&#46; The RET protein has a large extracellular domain containing a cysteine-rich region and a series of cadherin homology domains&#44; a transmembrane domain&#44; and an intracellular tyrosine kinase domain&#46; The positions of the most common mutations found in patients with multiple endocrine neoplasia type 2 &#40;MEN 2&#41; are shown&#46; &#40;B&#41; Mechanism of RET activation&#46; Wild-type RET activation requires the dimerization of RET&#44; mediated through formation of a multicomponent complex&#46; RET is activated by binding both a soluble ligand &#40;glial cell-line-derived neurotrophic factor&#59; GDNF&#41; and a non-signaling extracellular co-receptor &#40;GDNF family receptor&#59; GFR&#945;&#41;&#46; Upon activation of RET&#44; phosphorylation of multiple intracellular tyrosines leads to stimulation of downstream signaling pathways&#46;</p>"
        ]
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        "etiqueta" => "Figure 2"
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        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Molecular mechanisms of pathogenic RET activation&#46; Schematic diagrams showing mechanisms of RET activation in the presence of various multiple endocrine neoplasia type 2 &#40;MEN 2&#41; mutations&#46; &#40;A&#41; Substitutions of extracellular cysteines lead to formation of intermolecular disulfide bonds and to constitutive RET dimerization and activation&#46; &#40;B&#41; The MEN 2B mutation&#44; M918T &#40;star&#41; in the kinase domain&#44; leads to a conformational change with multiple effects including an increase in RET kinase activity and activation of receptors in either dimeric or monomeric form&#46; &#40;C&#41; Intracellular kinase domain mutations asterisk implicated in familial medullary thyroid carcinoma &#40;FMTC&#41; &#40;e&#46;g&#46; residues 791 and 891&#41;&#44; permit activation of monomeric RET&#44; allowing for a partially active conformation&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig3"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Structure of the RET tyrosine kinase domain&#46; Ribbon diagrams of the intracellular regions of activated RET&#44; in two orientations&#44; showing the positions of key functional features of the kinase&#58; the ATP binding pocket&#59; the activation or autoinhibitory loop&#59; and the substrate binding pocket&#46; Two orientations of the model&#44; displaying the autoinhibitory&#47;substrate binding face &#40;left&#41; and the ATP-binding face &#40;right&#41;&#44; are shown&#46; Amino acid residues that are mutated in patients with multiple endocrine neoplasia type 2 &#40;MEN 2&#41; are represented in the stick form&#46; The three-dimensional representation was based on the crystal structure of the phosphorylated &#40;activated&#41; RET tyrosine kinase domain &#40;residues 709&#8211;990&#41;&#46;</p>"
        ]
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        "identificador" => "tbl1"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">FMTC&#44; familial medullary thyroid carcinoma&#59; MEN 2&#44; multiple endocrine neoplasia 2&#59; RET&#44; <span class="elsevierStyleUnderline">RE</span>arranged during <span class="elsevierStyleUnderline">T</span>ransfection&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Mutation location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Affected RET Codons&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Putative function of thewild-type residue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Predicted mutation effects&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Phenotype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Recommendedintervention &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Extracellular- cysteine rich domain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">C609C611C618C620C630&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Contributes to tertiary structure of RET through the formation of intramolecular disulfide bonds&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Weakly activating&#46; Alteration in protein folding and maturation&#46;Formation of mutant RET dimers that are constitutively active in the absence of ligands&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">MEN 2A and FMTC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Prophylactic thyroid surgery before the age of 5&#46; Under some conditions may delay beyond 5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">C634&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Role in formation of intramolecular disulfide bonds&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Strongly activating&#46; Ligand-independent dimerization of receptor molecules&#44; enhanced phosphorylation of intracellular substrates&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">MEN 2A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Surgery before age 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Intracellular tyrosine kinase domain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">L790&#44; Y791&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">In the N-terminal lobe of the RET kinase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Moderately activating&#46; Affects ATP binding and inter-lobe flexibility&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">MEN 2A and FMTC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">May delay surgery beyond 5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">E768&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">In close proximity with the ATP binding site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Alters interactions within the region and facilitates the transition to an active conformation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">FMTC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">V804&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">A gatekeeper residue which regulates access to the ATP binding site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Alters hinge flexibility and positioning of RET helices for catalysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">FMTC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">S891&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">C-terminal lobe of the kinase&#44; adjacent to the activation loop of the kinase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Alters activation loop conformation and promotes monomeric RET activation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">MEN 2A and FMTC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">A883&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Situated next to activation loop&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Strongly activating&#46; Local conformational change which destabilizes the inactive form of the protein and promotes its activation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">MEN 2B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">As early as possible &#40;within first year of life&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">M918&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Lies in the substrate-binding pocket of the kinase and plays a role in stabilizing the receptor&#8211;ATP complex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Strongly activating&#46; Alters protein conformation and substrate specificity&#46; The mutant can dimerize and become phosphorylated in the absence of ligand stimulation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">MEN 2B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Molecular effects of RET mutations in multiple endocrine neoplasia 2&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:85 [
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                            3 => """
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                            4 => """
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                              """
                            5 => """
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                        ]
                      ]
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                  ]
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                        "tituloSerie" => "Cancer"
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            1 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation&#58; clinical manifestation and course in early and late onset disease"
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                        "fecha" => "2004"
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            2 => array:3 [
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              "referencia" => array:1 [
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                  "contribucion" => array:1 [
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                      "autores" => array:1 [
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                          "etal" => true
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                            0 => """
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                      "Revista" => array:5 [
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                      "autores" => array:1 [
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                              """
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                              """
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                      "Revista" => array:5 [
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                        "fecha" => "1994"
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                            "web" => "Medline"
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
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                              """
                            1 => """
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                              """
                            2 => """
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                              """
                            3 => """
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => """
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                              """
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                              """
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                      "autores" => array:1 [
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                          "etal" => true
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                              ML Brandi \n
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                              """
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            7 => array:3 [
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              "etiqueta" => "8"
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                  "contribucion" => array:1 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              RT Kloos \n
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                              """
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Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2012(Sup01)14

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