Surgical approach in patients with hyperparathyroidism in multiple endocrine neoplasia type 1: total versus partial parathyroidectomy

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The patient is placed in a hyperextension position. 1 – first incision is made below the last rib to create a retroperitoneal space; 2 – second port, 1 cm above the iliac crest, where the 0° endoscope enters; 3 – working port located 4 cm anterior to trocar number 2." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marcelo Hisano, Fabio Carvalho Vicentini, Miguel Srougi" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Marcelo" "apellidos" => "Hisano" ] 1 => array:2 [ "nombre" => "Fabio Carvalho" "apellidos" => "Vicentini" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Srougi" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222024139?idApp=UINPBA00004N" "url" => "/18075932/00000067000000S1/v1_202212010649/S1807593222024139/v1_202212010649/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222024115" "issn" => "18075932" "doi" => "10.6061/clinics/2012(Sup01)25" "estado" => "S300" "fechaPublicacion" => "2012-04-01" "aid" => "2411" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "rev" "cita" => "Clinics. 2012;67 Supl 1:149-54" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "REVIEW" "titulo" => "Surgical approach to medullary thyroid carcinoma associated with multiple endocrine neoplasia type 2" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "149" "paginaFinal" => "154" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 182 "Ancho" => 513 "Tamanyo" => 31397 ] ] "descripcion" => array:1 [ "en" => "Sublevels of the central compartment of the neck. Spaces of the central compartment of the neck: prelaryngeal (<a class="elsevierStyleCrossRef" href="#bib1">1</a>); lateral to the recurrent laryngeal nerves on the right (<a class="elsevierStyleCrossRef" href="#bib2">2</a>) and left (<a class="elsevierStyleCrossRef" href="#bib3">3</a>) sides; pretracheal, between the recurrent laryngeal nerves (<a class="elsevierStyleCrossRef" href="#bib4">4</a>)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marcos R. Tavares, Sérgio P.A. Toledo, Fábio L.M. Montenegro, Raquel A. Moyses, Rodrigo A. Toledo, Tomoko Sekyia, Claudio R. Cernea, Lenine G. Brandão" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Marcos R." "apellidos" => "Tavares" ] 1 => array:2 [ "nombre" => "Sérgio P.A." "apellidos" => "Toledo" ] 2 => array:2 [ "nombre" => "Fábio L.M." "apellidos" => "Montenegro" ] 3 => array:2 [ "nombre" => "Raquel A." "apellidos" => "Moyses" ] 4 => array:2 [ "nombre" => "Rodrigo A." 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"apellidos" => "Brandão" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222024115?idApp=UINPBA00004N" "url" => "/18075932/00000067000000S1/v1_202212010649/S1807593222024115/v1_202212010649/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "REVIEW" "titulo" => "Surgical approach in patients with hyperparathyroidism in multiple endocrine neoplasia type 1: total versus partial parathyroidectomy" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "155" "paginaFinal" => "160" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Francesco Tonelli, Francesco Giudici, Tiziana Cavalli, Maria Luisa Brandi" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Francesco" "apellidos" => "Tonelli" "email" => array:1 [ 0 => "francesco.tonelli@unifi.it" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Francesco" "apellidos" => "Giudici" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Tiziana" "apellidos" => "Cavalli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Maria Luisa" "apellidos" => "Brandi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "University of Florence, Department of Clinical Physiopathology, Surgical Unit, Florence, Italy." "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "University of Florence, Department of Internal Medicine, Florence, Italy." "etiqueta" => "II" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: +39-055-7947559" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 186 "Ancho" => 425 "Tamanyo" => 6755 ] ] "descripcion" => array:1 [ "en" => "Blood sampling after the removal of each parathyroid gland until the parathyroid hormone (PTH) values are practically undetectable in patients with HPT/MEN1 (6)." ] ] ] "textoCompleto" => "INTRODUCTIONUsually, primary hyperparathyroidism (HPT) is the first endocrinopathy to be diagnosed in patients with multiple endocrine neoplasia type 1 (MEN1), and is the most common one(<a class="elsevierStyleCrossRef" href="#bib1">1</a>). The optimal surgical timing and strategy in HPT/MEN1 are still under debate. The aims of surgery are to: correct hypercalcemia, and thus prevent persistent or recurrent hyperparathyroidism; avoid persistent hypoparathyroidism; and facilitate the surgical treatment of possible recurrences. Currently, two types of surgical approaches are indicated: subtotal parathyroidectomy (SPTX) with removal of at least 3–3.5 glands; and total parathyroidectomy with autologous graft of parathyroid tissue (TPTX). Transcervical thymectomy must be performed with both procedures.However, controlled clinical trials comparing SPTX and TPTX are lacking. Review of the published surgical data shows that persistent HPT is more frequent after SPTX than after TPTX, and recurrent hyperparathyroidism has a similar percentage in both surgical options. The recurrence rate is strongly influenced by the lack of a pre-operative diagnosis of MEN1, the surgeon's experience, the timing of the surgery, and the possibility of performing intra-operative confirmation [histologic examination and rapid parathyroid hormone (PTH) assay] of the potential curative capacity of the surgical procedure. To plan further operations, it is very helpful to have all the available data about previous surgery and to undertake accurate identification of the possible site of the recurrence.Penetrance in HPT/MEN1 is nearly 100% at the age of 50 years; the age of onset of biochemical alteration is usually 20–25 years(<a class="elsevierStyleCrossRef" href="#bib2">2</a>).As in sporadic HPT, diagnosis is usually prompted by the presence of hypercalcemia, with elevated serum levels of ionized calcium and PTH. Parathyroid gland involvement in MEN1 is asynchronous and asymmetrical; the change in volume varies, but the maximum/minimum mean volume ratio is 9.6(<a class="elsevierStyleCrossRef" href="#bib3">3</a>). Macroscopically normal parathyroid glands make up 12–55% of all glands; sometimes the intra-operative findings may consist of just one or two enlarged glands(<a class="elsevierStyleCrossRefs" href="#bib4">4–6</a>). Moreover, the frequency of supernumerary glands (up to 20% in HPT/MEN1)(<a class="elsevierStyleCrossRef" href="#bib6">6</a>),(<a class="elsevierStyleCrossRef" href="#bib7">7</a>) and of ectopic glands (often intrathymic, within the thyroid gland, in the anterior mediastinum) is higher than expected(<a class="elsevierStyleCrossRef" href="#bib5">5</a>),(<a class="elsevierStyleCrossRef" href="#bib8">8</a>). Some reports describe the presence of parathyroid nests (embryonic parathyroid rests, a direct result of ontogenesis) embedded within the fatty tissue surrounding the trachea, esophagus, and carotid artery(<a class="elsevierStyleCrossRefs" href="#bib8">8–11</a>). Genetic testing is the gold standard to confirm diagnosis of MEN1, and should be performed in any young patient with hyperparathyroidism, even in the absence of a clear familial history of MEN1 syndrome.Timing of surgeryThe optimal timing for surgery in HPT/MEN1 is still under debate. It is possible to follow the same indications used for sporadic HPT, taking into account that cases of HPT/MEN1 often have only mildly elevated calcium and PTH levels. However, even when MEN1-related HPT has a long asymptomatic phase, it is important to note that it is the cause of a detectable bone mass decrease at a young age(<a class="elsevierStyleCrossRef" href="#bib12">12</a>). Correction of hypercalcemia by prompt intervention is helpful in patients who show a decrease in bone mineral density, as it can prevent renal complications and may be of benefit for other concomitant endocrinopathies, such as hypergastrinemia(<a class="elsevierStyleCrossRef" href="#bib13">13</a>).In the case of concomitant multiple endocrinopathies in patients with HPT/MEN1, there is agreement among authors on the need to treat the HPT first, with the exception of cases of insulinoma.Surgical strategyThe aims of surgery are to correct hypercalcemia, preventing persistent or recurrent HPT; avoid persistent hypoparathyroidism; and facilitate the surgical treatment of possible recurrences.Less than subtotal parathyroidectomy, with removal of enlarged glands only, is associated with a high persistence/recurrence rate, so it is no longer used for diagnosed MEN1-HPT. Therefore, two surgical approaches are in routine use: SPTX, with removal of at least 3–3.5 glands, or TPTX. Transcervical thymectomy must be performed with both procedures as the thymus can harbor an ectopic parathyroid gland; thymectomy is also helpful in preventing thymic carcinoids possibly arising during the evolution of the syndrome.Subtotal parathyroidectomy (SPTX)SPTX is defined as the removal of three glands and part of the fourth (usually the least involved one), preserving not more than 50 mg of parathyroid tissue. The fourth gland can also be completely preserved if normal in volume. SPTX is used with the main aim of avoiding permanent hypoparathyroidism and also of reducing the risk of early postoperative hypocalcemia.SPTX becomes the surgical choice when a fourth parathyroid cannot be found out during surgery. This occurs in up to 20% of cases, even when treatment occurs in specialized centers(<a class="elsevierStyleCrossRef" href="#bib14">14</a>),(<a class="elsevierStyleCrossRef" href="#bib15">15</a>). Nevertheless, there are many criticisms leveled at SPTX as, in most cases, all the parathyroid glands are found to be pathologic and it is difficult to establish which of them is less involved and can be preserved.Furthermore, it can be difficult to preserve enough parathyroid tissue, particularly in the case of small glands. During this maneuver, the fine parathyroid vessels can easily be damaged, with consequent permanent hypoparathyroidism. In addition, surgery on these potentially pathologic glands could expose the patient to the risk of favoring the seeding of parathyroid cells into the nearest structures, thus favoring cervical recurrence of HPT(<a class="elsevierStyleCrossRef" href="#bib16">16</a>).All these considerations may explain the poor outcomes shown in several published studies, with high rates either of persistent and early recurrent HPT or of hypoparathyroidism (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>)(<a class="elsevierStyleCrossRefs" href="#bib4">4,5,13–15,17–29</a>).<elsevierMultimedia ident="tbl1"></elsevierMultimedia>Total parathyroidectomy (TPTX)TPTX consists of total parathyroidectomy with transcervical thymectomy and autologous transplantation of parathyroid tissue. The aim of this technique is to radically remove all the parathyroid tissue, including the occult gland potentially present within the thymus and the surrounding fatty tissues, to avoid cervical recurrences that are difficult to treat, and to reduce the risk of permanent hypoparathyroidism by means of a graft, usually in the nondominant forearm.The graft can be obtained at the end of surgery from fresh autologous tissue preserved at 4°C in Ringer lactate solution or days later (once it has been ascertained that the HPT has been cured) using cryopreserved tissue, using the technique described by Sonoda et al.(<a class="elsevierStyleCrossRef" href="#bib30">30</a>) and Wells et al.(<a class="elsevierStyleCrossRef" href="#bib31">31</a>). The tissue to graft should be chosen from the gland that appears most normal in volume, colour, and texture after analysis of frozen sections. The graft fragments should be the smallest possible (around 1 mm3) to facilitate the graft implant(<a class="elsevierStyleCrossRef" href="#bib32">32</a>). The optimal grafting site is generally the brachio-radialis muscle of the nondominant forearm. This procedure will allow monitoring of the success of the autotransplantation through bilateral blood sampling from each basilic vein for measurement of PTH levels. After incision of the fascia of the brachio-radialis muscle, its fibers are bluntly divided in order to create small spaces in which to embed 2–3 fragments of parathyroid tissue. The fascia is then sutured with nonabsorbable wires to mark the site. The number of fragments that should be grafted is still under debate, with various recommendations in the medical literature. Commonly 20–25 fragments (or more in the case of cryopreserved tissue) are considered the optimal number(<a class="elsevierStyleCrossRef" href="#bib33">33</a>). Other series report 5–10 transplanted fragments(<a class="elsevierStyleCrossRef" href="#bib23">23</a>),(<a class="elsevierStyleCrossRef" href="#bib24">24</a>), but with higher rates (50–60%) of nonworking grafts, either with fresh or cryopreserved parathyroid tissue (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>)(<a class="elsevierStyleCrossRefs" href="#bib13">13,17–20,22,28–30,33,35,36</a>). It is still unclear whether the success rate is associated with the technical procedure or with the parathyroid histopathology.<elsevierMultimedia ident="tbl2"></elsevierMultimedia>Interestingly, in the study by Janson and Tisell, no permanent hypoparathyroidism was seen and rapid parathyroid function restoration was observed after grafting parathyroid tissue within the abdominal subcutaneous fat in seven patients with MEN1(<a class="elsevierStyleCrossRef" href="#bib18">18</a>). In the past few years our center has moved towards implantation of eight fresh fragments instead of more than 12. This choice did not increase the number of cases of permanent hypoparathyroidism. We also implanted the autograft in the subcutaneous tissue of the nondominant forearm with the same optimal results. These data support the importance of local factors (i.e. angiogenesis) for the successful implantation of the graft (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>)(<a class="elsevierStyleCrossRefs" href="#bib13">13,17–20,22,28,30,35,36</a>).Cause of failure of treatment of MEN1-HPTUnsuccessful surgical treatment of HPT is more frequently observed in MEN1 than in sporadic HPT. Persistent hypoparathyroidism seems to be more frequent after SPTX than after TPTX (9% vs. 0.03%), and the cause may be related to hyperfunctioning parathyroid tissue in the portion of the gland preserved during SPTX. Conversely, recurrent hyperparathyroidism has a similar percentage in the two surgical strategies (18.6% vs. 18.5%); it is strongly dependent on the length of follow-up, and the cause may be related to the hyperfunctioning of the tissue if an excessive amount has been left in place after SPTX, or to the presence of supernumerary glands in cases treated with TPTX. There is no evidence in the literature of persistent or recurrent HPT/MEN1 cases caused by parathyreomatosis, although such cases have been reported in sporadic primary HPT (1–2%) and secondary HPT (12%)(<a class="elsevierStyleCrossRefs" href="#bib37">37–39</a>).The recurrence rate is strongly influenced by:1. Pre-operative diagnosis of MEN 1 significantly reduces the rate of surgical failures(<a class="elsevierStyleCrossRef" href="#bib5">5</a>),(<a class="elsevierStyleCrossRef" href="#bib40">40</a>) and pre-operative detection of a MEN1 gene mutation is essential when the clinical history is suggestive of MEN1.2. HPT/MEN1 persistence rates correlate with the experience of the surgeon, being significantly lower for surgeons working centers with high referral rates of HPT(<a class="elsevierStyleCrossRef" href="#bib17">17</a>).3. The optimal timing of surgery in asymptomatic cases with mild hypercalcemia is still debated. In fact, postponing surgery for some patients with MEN1 may increase the chances of identifying all the involved parathyroid glands, as over time, they become enlarged, making surgery easier and more effective.4. Intra-operative histologic examination is useful to confirm the presence of parathyroid tissue in the specimen, especially in doubtful cases when ectopic glands are found. Histologic confirmation may be of value when grafting fresh parathyroid tissue is programmed, making it possible to avoid grafting of fragments of tissue with pathologic histologic features.5. Rapid intra-operative PTH measurement has become important in clinical practice to guide the surgery(<a class="elsevierStyleCrossRef" href="#bib41">41</a>),(<a class="elsevierStyleCrossRef" href="#bib42">42</a>). Its sensitivity is reported as nearly 95% in surgical treatment of sporadic adenoma(<a class="elsevierStyleCrossRef" href="#bib4">4</a>),(<a class="elsevierStyleCrossRef" href="#bib42">42</a>),(<a class="elsevierStyleCrossRef" href="#bib43">43</a>). When used for the discrimination of HPT caused by hyperplasia or multiglandular disease, the rapid intra-operative PTH assay has shown substantially lower reliability, with a high rate of false positive values(<a class="elsevierStyleCrossRefs" href="#bib43">43–45</a>), probably due to the presence of glands suppressed (even if potentially neoplastic) by the most pathologic one. In fact, 10 minutes after removal of the first pathologic gland, PTH values can decrease by more than 50% from baseline. Using other criteria, such as evaluation after 20 minutes and a cut-off of 70%, Thompson et al. did not observe any false positive cases (<a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>)(<a class="elsevierStyleCrossRef" href="#bib46">46</a>). In our opinion, the main role of intra-operative PTH should be to confirm removal of all the parathyroid tissue, so that the search for other parathyroid glands can be stopped and the graft of fresh parathyroid tissue performed. In our experience, stepwise venous sampling after the removal of each parathyroid gland until the PTH values are almost undetectable (i.e. near to the sensitivity limit of the PTH assay used) is a reliable method to confirm effective parathyroidectomy and to indicate that parathyroid autotransplantation can proceed (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>)(<a class="elsevierStyleCrossRef" href="#bib6">6</a>).<elsevierMultimedia ident="tbl3"></elsevierMultimedia><elsevierMultimedia ident="fig1"></elsevierMultimedia>Treatment of persistent and recurrent MEN1-HPTTo plan further operations, it is very helpful to have all the available data regarding previous surgery and to undertake an accurate localization of the site of recurrence. If a forearm graft is present, circulating PTH levels should be monitored after arm ischemia for 30 minutes produced by a tourniquet, in order to establish if such values decrease until they become undetectable(<a class="elsevierStyleCrossRef" href="#bib47">47</a>). Re-operation is characterized by a substantial risk of inferior laryngeal nerve injury; therefore, it is indicated only when the recurrence is symptomatic, with high urinary calcium loss and significant bone mass reduction.In the case of cervical or mediastinal recurrence, the surgical option is to remove the entire residual parathyroid tissue and then to perform heterotopic autologous transplantation. This technique carries a low risk of persistent HPT.After TPTX with autograft, recurrence rates of 38% and 36%, respectively, were reported by Helmann et al.(<a class="elsevierStyleCrossRef" href="#bib20">20</a>) and Kivlen et al.(<a class="elsevierStyleCrossRef" href="#bib43">43</a>). However, TPTX without autograft is a possible choice for these patients after adequate informed consent, as they will need lifelong substitutive therapy with calcium and vitamin D.If recurrence is diagnosed at the graft site, the removal of transplanted tissue is the treatment of choice, even if the best results cannot be always achieved; a 42% cure rate was reported by Kivlen et al.(<a class="elsevierStyleCrossRef" href="#bib43">43</a>).Recently, a pharmacologic approach was proposed for the cure of sporadic primary or secondary HPT, with the introduction of calcimimetics, a new class of drugs with the property of reducing PTH release(<a class="elsevierStyleCrossRef" href="#bib48">48</a>),(<a class="elsevierStyleCrossRef" href="#bib49">49</a>). The efficacy of these molecules in HPT/MEN1, and particularly in its recurrence, needs to be proven through further studies and longer follow-up." "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "xpalclavsec1581192" "titulo" => "KEYWORDS" ] 1 => array:3 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "cesec20" "titulo" => "Timing of surgery" ] 1 => array:3 [ "identificador" => "cesec30" "titulo" => "Surgical strategy" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "cesec40" "titulo" => "Subtotal parathyroidectomy (SPTX)" ] 1 => array:2 [ "identificador" => "cesec50" "titulo" => "Total parathyroidectomy (TPTX)" ] ] ] 2 => array:2 [ "identificador" => "cesec60" "titulo" => "Cause of failure of treatment of MEN1-HPT" ] 3 => array:2 [ "identificador" => "cesec70" "titulo" => "Treatment of persistent and recurrent MEN1-HPT" ] ] ] 2 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1581192" "palabras" => array:5 [ 0 => "Primary hyperparathyroidism" 1 => "MEN1" 2 => "Surgery" 3 => "Total parathyroidectomy" 4 => "Subtotal parathyroidectomy" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:1 [ "resumen" => "Usually, primary hyperparathyroidism is the first endocrinopathy to be diagnosed in patients with multiple endocrine neoplasia type 1, and is also the most common one. The timing of the surgery and strategy in multiple endocrine neoplasia type 1/hyperparathyroidism are still under debate. The aims of surgery are to: 1) correct hypercalcemia, thus preventing persistent or recurrent hyperparathyroidism; 2) avoid persistent hypoparathyroidism; and 3) facilitate the surgical treatment of possible recurrences. Currently, two types of surgical approach are indicated: 1) subtotal parathyroidectomy with removal of at least 3–3½ glands; and 2) total parathyroidectomy with grafting of autologous parathyroid tissue. Transcervical thymectomy must be performed with both of these procedures. Unsuccessful surgical treatment of hyperparathyroidism is more frequently observed in multiple endocrine neoplasia type 1 than in sporadic hyperparathyroidism. The recurrence rate is strongly influenced by: 1) the lack of a pre-operative multiple endocrine neoplasia type 1 diagnosis; 2) the surgeon's experience; 3) the timing of surgery; 4) the possibility of performing intra-operative confirmation (histologic examination, rapid parathyroid hormone assay) of the curative potential of the surgical procedure; and, 5) the surgical strategy. Persistent hyperparathyroidism seems to be more frequent after subtotal parathyroidectomy than after total parathyroidectomy with autologous graft of parathyroid tissue. Conversely, recurrent hyperparathyroidism has a similar frequency in the two surgical strategies. To plan further operations, it is very helpful to know all the available data about previous surgery and to undertake accurate identification of the site of recurrence." ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "No potential conflict of interest was reported. Tonelli F is the principal author of the discussion about the best surgical approach for MEN1 patients. He operated and followed the clinical course of MEN1 patients affected by hyperparathyroidism treated in our Centre. Giudici F has reviewed literature, analyzing the differences between different types of surgery in patients with hyperparathyroidism in MEN1in terms of results and complications. Cavalli T has reviewed the literature on this subject and has contributed to the drafting of the article. Brandi ML has reviewed literature, contributing to the Article and the accuracy of the English language; she carried out the clinical and metabolic follow up of all the patients operated in our Centre." ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 186 "Ancho" => 425 "Tamanyo" => 6755 ] ] "descripcion" => array:1 [ "en" => "Blood sampling after the removal of each parathyroid gland until the parathyroid hormone (PTH) values are practically undetectable in patients with HPT/MEN1 (6)." ] ] 1 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "N.A. = not applicable." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col">Author \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Year \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Period \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Pts \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Mean follow-up (yrs) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Persistent HPT (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Recurrent HPT (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Hypoparathyroidism (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Edis et al. (<a class="elsevierStyleCrossRef" href="#bib23">23</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1979 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1959–76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Prinz et al. (<a class="elsevierStyleCrossRef" href="#bib24">24</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1981 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1955–76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Van Heerden et al. (<a class="elsevierStyleCrossRef" href="#bib25">25</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1983 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1960–83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Goretzki et al. (<a class="elsevierStyleCrossRef" href="#bib26">26</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1991 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1986–90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hellman et al. (<a class="elsevierStyleCrossRef" href="#bib17">17</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1992 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1982–91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">11.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">27.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">27.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Kraimps et al. (<a class="elsevierStyleCrossRef" href="#bib5">5</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1992 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1966–88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">O' Riordain et al. (<a class="elsevierStyleCrossRef" href="#bib15">15</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1970–91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16.4<a class="elsevierStyleCrossRef" href="#tfn1">∗</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Janson et al. (<a class="elsevierStyleCrossRef" href="#bib18">18</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1994 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1971–92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Thompson et al. (<a class="elsevierStyleCrossRef" href="#bib27">27</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1994 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1972–92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Grant at al. (<a class="elsevierStyleCrossRef" href="#bib28">28</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1994 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1980–93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">13.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Nilsson et al. (<a class="elsevierStyleCrossRef" href="#bib19">19</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1994 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1971–92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hellman et al. (<a class="elsevierStyleCrossRef" href="#bib20">20</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1998 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1969–96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Goudet et al. (<a class="elsevierStyleCrossRef" href="#bib14">14</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1986–97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Dotzenrath et al. (<a class="elsevierStyleCrossRef" href="#bib21">21</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1986–98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">8<a class="elsevierStyleCrossRef" href="#tfn1">∗</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Arnalsteen et al. (<a class="elsevierStyleCrossRef" href="#bib4">4</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1992–01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">33<a class="elsevierStyleCrossRef" href="#tfn1">∗</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Elaraj et al. (<a class="elsevierStyleCrossRef" href="#bib22">22</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1960–02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">51<a class="elsevierStyleCrossRef" href="#tfn1">∗</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">26 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hubbard et al. (<a class="elsevierStyleCrossRef" href="#bib29">29</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1974–02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Norton et al. (<a class="elsevierStyleCrossRef" href="#bib13">13</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1970–05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn1" "etiqueta" => "∗" "nota" => "Actuarial estimation." ] ] ] "descripcion" => array:1 [ "en" => "Results after subtotal parathyroidectomy (SPTX) in multiple endocrine neoplasia type 1 (MEN1)-hyperparathyroidism (HPT)." ] ] 2 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "N.A. = not applicable." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col">Author \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Year \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Period \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Pts \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Mean follow-up (yrs) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Persistent HPT (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Recurrent HPT (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Hypoparathyroidism (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Wells et al. (<a class="elsevierStyleCrossRef" href="#bib31">31</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1980 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1973–80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Malmaeus et al. (<a class="elsevierStyleCrossRef" href="#bib36">36</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1986 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1961–85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">26 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hellman et al. (<a class="elsevierStyleCrossRef" href="#bib17">17</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1992 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1982–91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Janson et al. (<a class="elsevierStyleCrossRef" href="#bib18">18</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1994 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1971–92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Dralle et al. (<a class="elsevierStyleCrossRef" href="#bib35">35</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1994 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1976–92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Nilsson et al. (<a class="elsevierStyleCrossRef" href="#bib19">19</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1994 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1971–92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hellmann et al. (<a class="elsevierStyleCrossRef" href="#bib20">20</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1998 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1969–96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">47 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Elaraj et al. (<a class="elsevierStyleCrossRef" href="#bib22">22</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1960–02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16<a class="elsevierStyleCrossRef" href="#tfn3">∗</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">46 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hubbard et al. (<a class="elsevierStyleCrossRef" href="#bib29">29</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1974–02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Norton et al. (<a class="elsevierStyleCrossRef" href="#bib13">13</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1970–05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Tonelli et al. (<a class="elsevierStyleCrossRef" href="#bib6">6</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1990–06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn3" "etiqueta" => "∗" "nota" => "Actuarial estimation." ] ] ] "descripcion" => array:1 [ "en" => "Results after total parathyroidectomy (TPTX) in multiple endocrine neoplasia type 1 (MEN1)-hyperparathyroidism (HPT)." ] ] 3 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col">Author \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Decrease of intra-operative PTH from baseline \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">False positive percentage<a class="elsevierStyleCrossRef" href="#tfn5">∗</a>) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Clerici et al. (<a class="elsevierStyleCrossRef" href="#bib44">44</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">>50% at 10′ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">75% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Jaskowiak et al. (<a class="elsevierStyleCrossRef" href="#bib45">45</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">>50% at 10′ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">50% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Kivlen et al. (<a class="elsevierStyleCrossRef" href="#bib43">43</a>)<a class="elsevierStyleCrossRef" href="#tfn6">†</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">>50% at 10′ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">14% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Arnalsteen et al. (<a class="elsevierStyleCrossRef" href="#bib4">4</a>)<a class="elsevierStyleCrossRef" href="#tfn6">†</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">>50% at 5′ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Thompson et al. (<a class="elsevierStyleCrossRef" href="#bib46">46</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">>70% at 20′ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0% \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tfn5" "etiqueta" => "∗" "nota" => "Decrease below the cut-off point in the presence of other enlarged gland/s." ] 1 => array:3 [ "identificador" => "tfn6" "etiqueta" => "†" "nota" => "Patients with MEN1 only." ] ] ] "descripcion" => array:1 [ "en" => "ntraoperative parathyroid hormone (PTH) monitoring for prediction of multi-glandular parathyroid disease after removal of the first pathological parathyroid gland." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:49 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyperparathyroidism in hereditary syndromes: special expression and special managements" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SJ Marx \n \t\t\t\t\t\t\t\t """ 1 => """ WF Simonds \n \t\t\t\t\t\t\t\t """ 2 => """ SK Agarwal \n \t\t\t\t\t\t\t\t """ 3 => """ AL Burns \n \t\t\t\t\t\t\t\t """ 4 => """ LS Weinstein \n \t\t\t\t\t\t\t\t """ 5 => """ C Cochran \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Bone Miner Res" "fecha" => "2002" "volumen" => "17" "numero" => "Suppl 2" "paginaInicial" => "37" "paginaFinal" => "43" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for diagnosis and therapy of MEN type1 and type2" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ ML Brandi \n \t\t\t\t\t\t\t\t """ 1 => """ RF Gagel \n \t\t\t\t\t\t\t\t """ 2 => """ A Angeli \n \t\t\t\t\t\t\t\t """ 3 => """ JP Bilezikian \n \t\t\t\t\t\t\t\t """ 4 => """ P Beck-Peccoz \n \t\t\t\t\t\t\t\t """ 5 => """ C Bordi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.86.12.8070" "Revista" => array:7 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2001" "volumen" => "86" "numero" => "12" "paginaInicial" => "5658" "paginaFinal" => "5671" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11739416" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1" 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Francesco TonelliI,

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Tel.: +39-055-7947559

, Francesco GiudiciI, Tiziana CavalliI, Maria Luisa BrandiII

I University of Florence, Department of Clinical Physiopathology, Surgical Unit, Florence, Italy.

II University of Florence, Department of Internal Medicine, Florence, Italy.

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          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Blood sampling after the removal of each parathyroid gland until the parathyroid hormone &#40;PTH&#41; values are practically undetectable in patients with HPT&#47;MEN1 &#40;6&#41;&#46;</p>"
        ]
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Usually&#44; primary hyperparathyroidism &#40;HPT&#41; is the first endocrinopathy to be diagnosed in patients with multiple endocrine neoplasia type 1 &#40;MEN1&#41;&#44; and is the most common one&#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41;&#46; The optimal surgical timing and strategy in HPT&#47;MEN1 are still under debate&#46; The aims of surgery are to&#58; correct hypercalcemia&#44; and thus prevent persistent or recurrent hyperparathyroidism&#59; avoid persistent hypoparathyroidism&#59; and facilitate the surgical treatment of possible recurrences&#46; Currently&#44; two types of surgical approaches are indicated&#58; subtotal parathyroidectomy &#40;SPTX&#41; with removal of at least 3&#8211;3&#46;5 glands&#59; and total parathyroidectomy with autologous graft of parathyroid tissue &#40;TPTX&#41;&#46; Transcervical thymectomy must be performed with both procedures&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">However&#44; controlled clinical trials comparing SPTX and TPTX are lacking&#46; Review of the published surgical data shows that persistent HPT is more frequent after SPTX than after TPTX&#44; and recurrent hyperparathyroidism has a similar percentage in both surgical options&#46; The recurrence rate is strongly influenced by the lack of a pre-operative diagnosis of MEN1&#44; the surgeon&#39;s experience&#44; the timing of the surgery&#44; and the possibility of performing intra-operative confirmation &#91;histologic examination and rapid parathyroid hormone &#40;PTH&#41; assay&#93; of the potential curative capacity of the surgical procedure&#46; To plan further operations&#44; it is very helpful to have all the available data about previous surgery and to undertake accurate identification of the possible site of the recurrence&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">Penetrance in HPT&#47;MEN1 is nearly 100&#37; at the age of 50 years&#59; the age of onset of biochemical alteration is usually 20&#8211;25 years&#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41;&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">As in sporadic HPT&#44; diagnosis is usually prompted by the presence of hypercalcemia&#44; with elevated serum levels of ionized calcium and PTH&#46; Parathyroid gland involvement in MEN1 is asynchronous and asymmetrical&#59; the change in volume varies&#44; but the maximum&#47;minimum mean volume ratio is 9&#46;6&#40;<a class="elsevierStyleCrossRef" href="#bib3">3</a>&#41;&#46; Macroscopically normal parathyroid glands make up 12&#8211;55&#37; of all glands&#59; sometimes the intra-operative findings may consist of just one or two enlarged glands&#40;<a class="elsevierStyleCrossRefs" href="#bib4">4&#8211;6</a>&#41;&#46; Moreover&#44; the frequency of supernumerary glands &#40;up to 20&#37; in HPT&#47;MEN1&#41;&#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41; and of ectopic glands &#40;often intrathymic&#44; within the thyroid gland&#44; in the anterior mediastinum&#41; is higher than expected&#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46; Some reports describe the presence of parathyroid nests &#40;embryonic parathyroid rests&#44; a direct result of ontogenesis&#41; embedded within the fatty tissue surrounding the trachea&#44; esophagus&#44; and carotid artery&#40;<a class="elsevierStyleCrossRefs" href="#bib8">8&#8211;11</a>&#41;&#46; Genetic testing is the gold standard to confirm diagnosis of MEN1&#44; and should be performed in any young patient with hyperparathyroidism&#44; even in the absence of a clear familial history of MEN1 syndrome&#46;</p><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">Timing of surgery</span><p id="para50" class="elsevierStylePara elsevierViewall">The optimal timing for surgery in HPT&#47;MEN1 is still under debate&#46; It is possible to follow the same indications used for sporadic HPT&#44; taking into account that cases of HPT&#47;MEN1 often have only mildly elevated calcium and PTH levels&#46; However&#44; even when MEN1-related HPT has a long asymptomatic phase&#44; it is important to note that it is the cause of a detectable bone mass decrease at a young age&#40;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#41;&#46; Correction of hypercalcemia by prompt intervention is helpful in patients who show a decrease in bone mineral density&#44; as it can prevent renal complications and may be of benefit for other concomitant endocrinopathies&#44; such as hypergastrinemia&#40;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41;&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">In the case of concomitant multiple endocrinopathies in patients with HPT&#47;MEN1&#44; there is agreement among authors on the need to treat the HPT first&#44; with the exception of cases of insulinoma&#46;</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">Surgical strategy</span><p id="para70" class="elsevierStylePara elsevierViewall">The aims of surgery are to correct hypercalcemia&#44; preventing persistent or recurrent HPT&#59; avoid persistent hypoparathyroidism&#59; and facilitate the surgical treatment of possible recurrences&#46;</p><p id="para80" class="elsevierStylePara elsevierViewall">Less than subtotal parathyroidectomy&#44; with removal of enlarged glands only&#44; is associated with a high persistence&#47;recurrence rate&#44; so it is no longer used for diagnosed MEN1-HPT&#46; Therefore&#44; two surgical approaches are in routine use&#58; SPTX&#44; with removal of at least 3&#8211;3&#46;5 glands&#44; or TPTX&#46; Transcervical thymectomy must be performed with both procedures as the thymus can harbor an ectopic parathyroid gland&#59; thymectomy is also helpful in preventing thymic carcinoids possibly arising during the evolution of the syndrome&#46;</p><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">Subtotal parathyroidectomy &#40;SPTX&#41;</span><p id="para90" class="elsevierStylePara elsevierViewall">SPTX is defined as the removal of three glands and part of the fourth &#40;usually the least involved one&#41;&#44; preserving not more than 50 mg of parathyroid tissue&#46; The fourth gland can also be completely preserved if normal in volume&#46; SPTX is used with the main aim of avoiding permanent hypoparathyroidism and also of reducing the risk of early postoperative hypocalcemia&#46;</p><p id="para100" class="elsevierStylePara elsevierViewall">SPTX becomes the surgical choice when a fourth parathyroid cannot be found out during surgery&#46; This occurs in up to 20&#37; of cases&#44; even when treatment occurs in specialized centers&#40;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#46; Nevertheless&#44; there are many criticisms leveled at SPTX as&#44; in most cases&#44; all the parathyroid glands are found to be pathologic and it is difficult to establish which of them is less involved and can be preserved&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">Furthermore&#44; it can be difficult to preserve enough parathyroid tissue&#44; particularly in the case of small glands&#46; During this maneuver&#44; the fine parathyroid vessels can easily be damaged&#44; with consequent permanent hypoparathyroidism&#46; In addition&#44; surgery on these potentially pathologic glands could expose the patient to the risk of favoring the seeding of parathyroid cells into the nearest structures&#44; thus favoring cervical recurrence of HPT&#40;<a class="elsevierStyleCrossRef" href="#bib16">16</a>&#41;&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">All these considerations may explain the poor outcomes shown in several published studies&#44; with high rates either of persistent and early recurrent HPT or of hypoparathyroidism &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#41;&#40;<a class="elsevierStyleCrossRefs" href="#bib4">4&#44;5&#44;13&#8211;15&#44;17&#8211;29</a>&#41;&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">Total parathyroidectomy &#40;TPTX&#41;</span><p id="para130" class="elsevierStylePara elsevierViewall">TPTX consists of total parathyroidectomy with transcervical thymectomy and autologous transplantation of parathyroid tissue&#46; The aim of this technique is to radically remove all the parathyroid tissue&#44; including the occult gland potentially present within the thymus and the surrounding fatty tissues&#44; to avoid cervical recurrences that are difficult to treat&#44; and to reduce the risk of permanent hypoparathyroidism by means of a graft&#44; usually in the nondominant forearm&#46;</p><p id="para140" class="elsevierStylePara elsevierViewall">The graft can be obtained at the end of surgery from fresh autologous tissue preserved at 4&#176;C in Ringer lactate solution or days later &#40;once it has been ascertained that the HPT has been cured&#41; using cryopreserved tissue&#44; using the technique described by Sonoda et al&#46;&#40;<a class="elsevierStyleCrossRef" href="#bib30">30</a>&#41; and Wells et al&#46;&#40;<a class="elsevierStyleCrossRef" href="#bib31">31</a>&#41;&#46; The tissue to graft should be chosen from the gland that appears most normal in volume&#44; colour&#44; and texture after analysis of frozen sections&#46; The graft fragments should be the smallest possible &#40;around 1 mm<span class="elsevierStyleSup">3</span>&#41; to facilitate the graft implant&#40;<a class="elsevierStyleCrossRef" href="#bib32">32</a>&#41;&#46; The optimal grafting site is generally the brachio-radialis muscle of the nondominant forearm&#46; This procedure will allow monitoring of the success of the autotransplantation through bilateral blood sampling from each basilic vein for measurement of PTH levels&#46; After incision of the fascia of the brachio-radialis muscle&#44; its fibers are bluntly divided in order to create small spaces in which to embed 2&#8211;3 fragments of parathyroid tissue&#46; The fascia is then sutured with nonabsorbable wires to mark the site&#46; The number of fragments that should be grafted is still under debate&#44; with various recommendations in the medical literature&#46; Commonly 20&#8211;25 fragments &#40;or more in the case of cryopreserved tissue&#41; are considered the optimal number&#40;<a class="elsevierStyleCrossRef" href="#bib33">33</a>&#41;&#46; Other series report 5&#8211;10 transplanted fragments&#40;<a class="elsevierStyleCrossRef" href="#bib23">23</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#41;&#44; but with higher rates &#40;50&#8211;60&#37;&#41; of nonworking grafts&#44; either with fresh or cryopreserved parathyroid tissue &#40;<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#41;&#40;<a class="elsevierStyleCrossRefs" href="#bib13">13&#44;17&#8211;20&#44;22&#44;28&#8211;30&#44;33&#44;35&#44;36</a>&#41;&#46; It is still unclear whether the success rate is associated with the technical procedure or with the parathyroid histopathology&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><p id="para150" class="elsevierStylePara elsevierViewall">Interestingly&#44; in the study by Janson and Tisell&#44; no permanent hypoparathyroidism was seen and rapid parathyroid function restoration was observed after grafting parathyroid tissue within the abdominal subcutaneous fat in seven patients with MEN1&#40;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#41;&#46; In the past few years our center has moved towards implantation of eight fresh fragments instead of more than 12&#46; This choice did not increase the number of cases of permanent hypoparathyroidism&#46; We also implanted the autograft in the subcutaneous tissue of the nondominant forearm with the same optimal results&#46; These data support the importance of local factors &#40;i&#46;e&#46; angiogenesis&#41; for the successful implantation of the graft &#40;<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#41;&#40;<a class="elsevierStyleCrossRefs" href="#bib13">13&#44;17&#8211;20&#44;22&#44;28&#44;30&#44;35&#44;36</a>&#41;&#46;</p></span></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">Cause of failure of treatment of MEN1-HPT</span><p id="para160" class="elsevierStylePara elsevierViewall">Unsuccessful surgical treatment of HPT is more frequently observed in MEN1 than in sporadic HPT&#46; Persistent hypoparathyroidism seems to be more frequent after SPTX than after TPTX &#40;9&#37; vs&#46; 0&#46;03&#37;&#41;&#44; and the cause may be related to hyperfunctioning parathyroid tissue in the portion of the gland preserved during SPTX&#46; Conversely&#44; recurrent hyperparathyroidism has a similar percentage in the two surgical strategies &#40;18&#46;6&#37; vs&#46; 18&#46;5&#37;&#41;&#59; it is strongly dependent on the length of follow-up&#44; and the cause may be related to the hyperfunctioning of the tissue if an excessive amount has been left in place after SPTX&#44; or to the presence of supernumerary glands in cases treated with TPTX&#46; There is no evidence in the literature of persistent or recurrent HPT&#47;MEN1 cases caused by parathyreomatosis&#44; although such cases have been reported in sporadic primary HPT &#40;1&#8211;2&#37;&#41; and secondary HPT &#40;12&#37;&#41;&#40;<a class="elsevierStyleCrossRefs" href="#bib37">37&#8211;39</a>&#41;&#46;</p><p id="para170" class="elsevierStylePara elsevierViewall">The recurrence rate is strongly influenced by&#58;</p><p id="para180" class="elsevierStylePara elsevierViewall">1&#46; Pre-operative diagnosis of MEN 1 significantly reduces the rate of surgical failures&#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib40">40</a>&#41; and pre-operative detection of a <span class="elsevierStyleItalic">MEN1</span> gene mutation is essential when the clinical history is suggestive of MEN1&#46;</p><p id="para190" class="elsevierStylePara elsevierViewall">2&#46; HPT&#47;MEN1 persistence rates correlate with the experience of the surgeon&#44; being significantly lower for surgeons working centers with high referral rates of HPT&#40;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#41;&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">3&#46; The optimal timing of surgery in asymptomatic cases with mild hypercalcemia is still debated&#46; In fact&#44; postponing surgery for some patients with MEN1 may increase the chances of identifying all the involved parathyroid glands&#44; as over time&#44; they become enlarged&#44; making surgery easier and more effective&#46;</p><p id="para210" class="elsevierStylePara elsevierViewall">4&#46; Intra-operative histologic examination is useful to confirm the presence of parathyroid tissue in the specimen&#44; especially in doubtful cases when ectopic glands are found&#46; Histologic confirmation may be of value when grafting fresh parathyroid tissue is programmed&#44; making it possible to avoid grafting of fragments of tissue with pathologic histologic features&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall">5&#46; Rapid intra-operative PTH measurement has become important in clinical practice to guide the surgery&#40;<a class="elsevierStyleCrossRef" href="#bib41">41</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib42">42</a>&#41;&#46; Its sensitivity is reported as nearly 95&#37; in surgical treatment of sporadic adenoma&#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib42">42</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib43">43</a>&#41;&#46; When used for the discrimination of HPT caused by hyperplasia or multiglandular disease&#44; the rapid intra-operative PTH assay has shown substantially lower reliability&#44; with a high rate of false positive values&#40;<a class="elsevierStyleCrossRefs" href="#bib43">43&#8211;45</a>&#41;&#44; probably due to the presence of glands suppressed &#40;even if potentially neoplastic&#41; by the most pathologic one&#46; In fact&#44; 10 minutes after removal of the first pathologic gland&#44; PTH values can decrease by more than 50&#37; from baseline&#46; Using other criteria&#44; such as evaluation after 20 minutes and a cut-off of 70&#37;&#44; Thompson et al&#46; did not observe any false positive cases &#40;<a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>&#41;&#40;<a class="elsevierStyleCrossRef" href="#bib46">46</a>&#41;&#46; In our opinion&#44; the main role of intra-operative PTH should be to confirm removal of all the parathyroid tissue&#44; so that the search for other parathyroid glands can be stopped and the graft of fresh parathyroid tissue performed&#46; In our experience&#44; stepwise venous sampling after the removal of each parathyroid gland until the PTH values are almost undetectable &#40;i&#46;e&#46; near to the sensitivity limit of the PTH assay used&#41; is a reliable method to confirm effective parathyroidectomy and to indicate that parathyroid autotransplantation can proceed &#40;<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>&#41;&#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#46;</p><elsevierMultimedia ident="tbl3"></elsevierMultimedia><elsevierMultimedia ident="fig1"></elsevierMultimedia></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Treatment of persistent and recurrent MEN1-HPT</span><p id="para230" class="elsevierStylePara elsevierViewall">To plan further operations&#44; it is very helpful to have all the available data regarding previous surgery and to undertake an accurate localization of the site of recurrence&#46; If a forearm graft is present&#44; circulating PTH levels should be monitored after arm ischemia for 30 minutes produced by a tourniquet&#44; in order to establish if such values decrease until they become undetectable&#40;<a class="elsevierStyleCrossRef" href="#bib47">47</a>&#41;&#46; Re-operation is characterized by a substantial risk of inferior laryngeal nerve injury&#59; therefore&#44; it is indicated only when the recurrence is symptomatic&#44; with high urinary calcium loss and significant bone mass reduction&#46;</p><p id="para240" class="elsevierStylePara elsevierViewall">In the case of cervical or mediastinal recurrence&#44; the surgical option is to remove the entire residual parathyroid tissue and then to perform heterotopic autologous transplantation&#46; This technique carries a low risk of persistent HPT&#46;</p><p id="para250" class="elsevierStylePara elsevierViewall">After TPTX with autograft&#44; recurrence rates of 38&#37; and 36&#37;&#44; respectively&#44; were reported by Helmann et al&#46;&#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41; and Kivlen et al&#46;&#40;<a class="elsevierStyleCrossRef" href="#bib43">43</a>&#41;&#46; However&#44; TPTX without autograft is a possible choice for these patients after adequate informed consent&#44; as they will need lifelong substitutive therapy with calcium and vitamin D&#46;</p><p id="para260" class="elsevierStylePara elsevierViewall">If recurrence is diagnosed at the graft site&#44; the removal of transplanted tissue is the treatment of choice&#44; even if the best results cannot be always achieved&#59; a 42&#37; cure rate was reported by Kivlen et al&#46;&#40;<a class="elsevierStyleCrossRef" href="#bib43">43</a>&#41;&#46;</p><p id="para270" class="elsevierStylePara elsevierViewall">Recently&#44; a pharmacologic approach was proposed for the cure of sporadic primary or secondary HPT&#44; with the introduction of calcimimetics&#44; a new class of drugs with the property of reducing PTH release&#40;<a class="elsevierStyleCrossRef" href="#bib48">48</a>&#41;&#44;&#40;<a class="elsevierStyleCrossRef" href="#bib49">49</a>&#41;&#46; The efficacy of these molecules in HPT&#47;MEN1&#44; and particularly in its recurrence&#44; needs to be proven through further studies and longer follow-up&#46;</p></span></span></span>"
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        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Usually&#44; primary hyperparathyroidism is the first endocrinopathy to be diagnosed in patients with multiple endocrine neoplasia type 1&#44; and is also the most common one&#46; The timing of the surgery and strategy in multiple endocrine neoplasia type 1&#47;hyperparathyroidism are still under debate&#46; The aims of surgery are to&#58; 1&#41; correct hypercalcemia&#44; thus preventing persistent or recurrent hyperparathyroidism&#59; 2&#41; avoid persistent hypoparathyroidism&#59; and 3&#41; facilitate the surgical treatment of possible recurrences&#46; Currently&#44; two types of surgical approach are indicated&#58; 1&#41; subtotal parathyroidectomy with removal of at least 3&#8211;3&#189; glands&#59; and 2&#41; total parathyroidectomy with grafting of autologous parathyroid tissue&#46; Transcervical thymectomy must be performed with both of these procedures&#46; Unsuccessful surgical treatment of hyperparathyroidism is more frequently observed in multiple endocrine neoplasia type 1 than in sporadic hyperparathyroidism&#46; The recurrence rate is strongly influenced by&#58; 1&#41; the lack of a pre-operative multiple endocrine neoplasia type 1 diagnosis&#59; 2&#41; the surgeon&#39;s experience&#59; 3&#41; the timing of surgery&#59; 4&#41; the possibility of performing intra-operative confirmation &#40;histologic examination&#44; rapid parathyroid hormone assay&#41; of the curative potential of the surgical procedure&#59; and&#44; 5&#41; the surgical strategy&#46; Persistent hyperparathyroidism seems to be more frequent after subtotal parathyroidectomy than after total parathyroidectomy with autologous graft of parathyroid tissue&#46; Conversely&#44; recurrent hyperparathyroidism has a similar frequency in the two surgical strategies&#46; To plan further operations&#44; it is very helpful to know all the available data about previous surgery and to undertake accurate identification of the site of recurrence&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="cenpara50">No potential conflict of interest was reported&#46;</p> <p class="elsevierStyleNotepara" id="cenpara60">Tonelli F is the principal author of the discussion about the best surgical approach for MEN1 patients&#46; He operated and followed the clinical course of MEN1 patients affected by hyperparathyroidism treated in our Centre&#46; Giudici F has reviewed literature&#44; analyzing the differences between different types of surgery in patients with hyperparathyroidism in MEN1in terms of results and complications&#46; Cavalli T has reviewed the literature on this subject and has contributed to the drafting of the article&#46; Brandi ML has reviewed literature&#44; contributing to the Article and the accuracy of the English language&#59; she carried out the clinical and metabolic follow up of all the patients operated in our Centre&#46;</p>"
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          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Blood sampling after the removal of each parathyroid gland until the parathyroid hormone &#40;PTH&#41; values are practically undetectable in patients with HPT&#47;MEN1 &#40;6&#41;&#46;</p>"
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          "leyenda" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">N&#46;A&#46; &#61; not applicable&#46;</p>"
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                  \t\t\t\t  " align="left" valign="top" scope="col">Author&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="top" scope="col">Year&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="top" scope="col">Period&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="top" scope="col">Pts&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="top" scope="col">Mean follow-up &#40;yrs&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Recurrent HPT &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Hypoparathyroidism &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Edis et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib23">23</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1979&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1959&#8211;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Prinz et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1981&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1955&#8211;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Van Heerden et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib25">25</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1960&#8211;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Goretzki et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib26">26</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1991&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1986&#8211;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Hellman et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1992&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1982&#8211;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">11&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">27&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">27&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Kraimps et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1992&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1966&#8211;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">O&#39; Riordain et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1970&#8211;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16&#46;4<a class="elsevierStyleCrossRef" href="#tfn1">&#8727;</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Janson et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1971&#8211;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Thompson et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib27">27</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1972&#8211;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Grant at al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib28">28</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1980&#8211;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">4&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">13&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Nilsson et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1971&#8211;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Hellman et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1998&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1969&#8211;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Goudet et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1986&#8211;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Dotzenrath et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib21">21</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1986&#8211;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">8<a class="elsevierStyleCrossRef" href="#tfn1">&#8727;</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Arnalsteen et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1992&#8211;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">33<a class="elsevierStyleCrossRef" href="#tfn1">&#8727;</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Elaraj et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib22">22</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1960&#8211;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">51<a class="elsevierStyleCrossRef" href="#tfn1">&#8727;</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Hubbard et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1974&#8211;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Norton et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1970&#8211;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tfn1"
              "etiqueta" => "&#8727;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">Actuarial estimation&#46;</p>"
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          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Results after subtotal parathyroidectomy &#40;SPTX&#41; in multiple endocrine neoplasia type 1 &#40;MEN1&#41;-hyperparathyroidism &#40;HPT&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl2"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">N&#46;A&#46; &#61; not applicable&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Author&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Period&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Pts&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Mean follow-up &#40;yrs&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Persistent HPT &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Recurrent HPT &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Hypoparathyroidism &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Wells et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib31">31</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1980&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1973&#8211;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Malmaeus et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib36">36</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1986&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1961&#8211;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Hellman et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1992&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1982&#8211;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Janson et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1971&#8211;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Dralle et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib35">35</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1976&#8211;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Nilsson et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1994&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1971&#8211;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Hellmann et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1998&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1969&#8211;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Elaraj et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib22">22</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1960&#8211;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">N&#46;A&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16<a class="elsevierStyleCrossRef" href="#tfn3">&#8727;</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Hubbard et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1974&#8211;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Norton et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1970&#8211;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Tonelli et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1990&#8211;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
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            0 => array:3 [
              "identificador" => "tfn3"
              "etiqueta" => "&#8727;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">Actuarial estimation&#46;</p>"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Results after total parathyroidectomy &#40;TPTX&#41; in multiple endocrine neoplasia type 1 &#40;MEN1&#41;-hyperparathyroidism &#40;HPT&#41;&#46;</p>"
        ]
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        "identificador" => "tbl3"
        "etiqueta" => "Table 3"
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        "mostrarDisplay" => false
        "tabla" => array:2 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Author&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="top" scope="col">Decrease of intra-operative PTH from baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">False positive percentage<a class="elsevierStyleCrossRef" href="#tfn5">&#8727;</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Clerici et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib44">44</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#62;50&#37; at 10&#8242;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">75&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Jaskowiak et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib45">45</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#62;50&#37; at 10&#8242;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Kivlen et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib43">43</a>&#41;<a class="elsevierStyleCrossRef" href="#tfn6">&#8224;</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#62;50&#37; at 10&#8242;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">14&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Arnalsteen et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41;<a class="elsevierStyleCrossRef" href="#tfn6">&#8224;</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#62;50&#37; at 5&#8242;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Thompson et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib46">46</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#62;70&#37; at 20&#8242;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "etiqueta" => "&#8727;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara30">Decrease below the cut-off point in the presence of other enlarged gland&#47;s&#46;</p>"
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            1 => array:3 [
              "identificador" => "tfn6"
              "etiqueta" => "&#8224;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara40">Patients with MEN1 only&#46;</p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">ntraoperative parathyroid hormone &#40;PTH&#41; monitoring for prediction of multi-glandular parathyroid disease after removal of the first pathological parathyroid gland&#46;</p>"
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      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:49 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyperparathyroidism in hereditary syndromes&#58; special expression and special managements"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              SJ Marx \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              WF Simonds \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SK Agarwal \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              AL Burns \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              LS Weinstein \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              C Cochran \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2002"
                        "volumen" => "17"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "37"
                        "paginaFinal" => "43"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for diagnosis and therapy of MEN type1 and type2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              ML Brandi \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RF Gagel \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Angeli \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JP Bilezikian \n
                              \t\t\t\t\t\t\t\t
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Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2012(Sup01)26

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Year/Month	Html	Pdf	Total

2024 November	5	0	5
2024 October	53	30	83
2024 September	53	24	77
2024 August	62	28	90
2024 July	46	25	71
2024 June	24	21	45
2024 May	30	11	41
2024 April	26	32	58
2024 March	46	17	63
2024 February	54	16	70
2024 January	17	17	34
2023 December	15	23	38
2023 November	23	17	40
2023 October	14	21	35
2023 September	13	22	35
2023 August	5	5	10
2023 July	11	19	30
2023 June	5	2	7
2023 May	0	2	2
2023 April	1	3	4
2023 March	1	5	6
2023 February	1	0	1
2023 January	1	2	3
2022 December	1	2	3

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