Letters to the Editor
Ovarian vein thrombosis and mirror syndrome in association with sacrococcygeal teratoma
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array:23 [ "pii" => "S1807593222024632" "issn" => "18075932" "doi" => "10.1590/S1807-59322010000400017" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "20222463" "copyright" => "CLINICS" "copyrightAnyo" => "2010" "documento" => "simple-article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "cor" "cita" => "Clinics. 2010;65:452-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemAnterior" => array:19 [ "pii" => "S1807593222024620" "issn" => "18075932" "doi" => "10.1590/S1807-59322010000400016" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "20222462" "copyright" => "CLINICS" "documento" => "simple-article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "cor" "cita" => "Clinics. 2010;65:449-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the Editor</span>" "titulo" => "Double right coronary artery: a report of two cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "449" "paginaFinal" => "451" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f2-cln_65p449" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 422 "Ancho" => 423 "Tamanyo" => 22622 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Selective right coronary angiography (left anterior oblique projection).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yusuf Selcoki, Omer Caglar Yilmaz, Okan Er, Beyhan Eryonucu" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Yusuf" "apellidos" => "Selcoki" ] 1 => array:2 [ "nombre" => "Omer Caglar" "apellidos" => "Yilmaz" ] 2 => array:2 [ "nombre" => "Okan" "apellidos" => "Er" ] 3 => array:2 [ "nombre" => "Beyhan" "apellidos" => "Eryonucu" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222024620?idApp=UINPBA00004N" "url" => "/18075932/0000006500000004/v1_202212011714/S1807593222024620/v1_202212011714/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the Editor</span>" "titulo" => "Ovarian vein thrombosis and mirror syndrome in association with sacrococcygeal teratoma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "452" "paginaFinal" => "455" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Hasan Kafali, Yüksel Arıkan Onaran, Esra Keskin, Umut Sari, Ismail Kirbas" "autores" => array:5 [ 0 => array:4 [ "preGrado" => "MD" "nombre" => "Hasan" "apellidos" => "Kafali" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "afI-cln_65p452" ] ] ] 1 => array:3 [ "nombre" => "Yüksel Arıkan" "apellidos" => "Onaran" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "afI-cln_65p452" ] ] ] 2 => array:3 [ "nombre" => "Esra" "apellidos" => "Keskin" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "afI-cln_65p452" ] ] ] 3 => array:3 [ "nombre" => "Umut" "apellidos" => "Sari" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "afI-cln_65p452" ] ] ] 4 => array:4 [ "nombre" => "Ismail" "apellidos" => "Kirbas" "email" => array:1 [ 0 => "hasankafali@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "afII-cln_65p452" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Obstetrics and Gynecology Department, Fatih University Medical School - Çankaya/Ankara, Turkey" "etiqueta" => "I" "identificador" => "afI-cln_65p452" ] 1 => array:3 [ "entidad" => "Radiology Department, Fatih University Medical School - Çankaya/Ankara, Turkey" "etiqueta" => "II" "identificador" => "afII-cln_65p452" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f3-cln_65p452" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 482 "Ancho" => 432 "Tamanyo" => 24194 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">A computed tomographic image that depicts the obstruction of the right ureter (thin arrow) by the enlarged right ovarian vein (thick dashed arrow).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Ballantyne’s syndrome has originally been described for hydrops fetalis, which is associated with rhesus isoimmunization; however, hydrops fetalis can also occur in association with non-immunological causes, including Ebstein’s anomaly, Galen’s vein aneurysm, fetal arrhythmias, and sacrococcygeal teratoma (SCT). SCT is the most commonly presenting tumor in newborn babies, occurring in approximately 1 in every 40,000 live births. Large or rapidly growing tumors are highly vascular, and lead to high-output cardiac failure, which is characteristic of hydrops fetalis. In non-immune hydrops fetalis maternal preeclampsia (Mirror syndrome) can also sometimes occur. The clinical manifestations of mirror syndrome are quite varied, and the pathophysiology of this syndrome is poorly understood.<a class="elsevierStyleCrossRef" href="#bib1">1</a>–<a class="elsevierStyleCrossRef" href="#bib3">3</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Ovarian vein thrombosis (OVT) is a rare complication of pregnancy; however, recognition and treatment of this condition are critical because a delay in diagnosis can lead to significant maternal morbidity. The diagnosis of OVT remains a challenge because there is no known profile of risk factors.<a class="elsevierStyleCrossRef" href="#bib4">4</a> In this manuscript, we describe a case of a rapidly growing SCT that is associated with Mirror syndrome and ovarian vein thrombosis.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">CASE REPORT</span><p id="para30" class="elsevierStylePara elsevierViewall">A 28-year-old G3P1A1 female was referred to our obstetrics and gynecology department after diagnosis of a fetal SCT with solid and cystic components via routine ultrasound at 16 weeks of gestation. The SCT exhibited a cross-sectional area of 5.6×6.4 cm<span class="elsevierStyleSup">2</span> and there was also evidence of hydronephrosis and bladder compression. There was no evidence of fetal hydrops fetalis and the initial echocardiogram was normal. This patient’s amniotic fluid index was 18 cm. The next fetal ultrasound at 20 weeks demonstrated placentomegaly and polyhydramnios, cross-sectional area of the teratoma was found increased from 5.6×6.4 cm<span class="elsevierStyleSup">2</span> to 8.2×9.5 cm<span class="elsevierStyleSup">2</span>. At 28 weeks, the SCT cross-sectional area was observed to have increased to 17×12 cm<span class="elsevierStyleSup">2</span>. At this point in time, the fetus exhibited generalized skin and scalp edema, abdominal ascites, and pericardial and pleural effusions. The umbilical cord systolic/diastolic ratio was 5.2, with only very subtle umbilical venous pulsations. There was no flow reversal evident in the ductus venosus waveform. The middle cerebral artery flow was 59.5 cm/sec, which is consistent with fetal anemia. Based on an elevation in the middle cerebral artery flow, which is suggestive of fetal anemia, in addition to the ultrasound findings of generalized edema, ascites, and pericardial and pleural effusions, we concluded that the fetus was severely hydropic. After counseling, the decision was made to continue observation and intervene in the pregnancy for maternal benefit only. Two days later after her last visit, the mother was admitted to the hospital due to right lumbar pain and increased lower extremity swelling. Her physical and laboratory examinations showed +++ proteinuria, elevated blood pressure (160/90), and grade I hydronephrosis. Intrauterine ex occurred on the second day of the patient’s hospitalization. An 860 g female infant was delivered at 28 and 4/7 weeks by cesarean delivery with Apgar scores of zero at 1<span class="elsevierStyleSup">th</span> and 5<span class="elsevierStyleSup">th</span> minute after delivery</p><p id="para40" class="elsevierStylePara elsevierViewall">The placenta weighed 980 g. The infant was noted as having marked pitting skin edema, significant pleural effusions, abdominal ascites, and an SCT approximately equal in volume to the remainder of her body (<a class="elsevierStyleCrossRef" href="#f1-cln_65p452">Figure 1</a>).</p><elsevierMultimedia ident="f1-cln_65p452"></elsevierMultimedia><p id="para50" class="elsevierStylePara elsevierViewall">On the second postoperative day, the mother exhibited pain in the right iliac fossa and pyrexia (38°C). An abdominal examination revealed right lower quadrant tenderness that radiated to the ipsilateral flank, rebound tenderness, and right lumbar pain. The patient’s white blood cell count was 1100/μl, and a blood coagulation profile showed an activated partial thromboblastin time of 37 s (normal value: 25–40), a derived fibrinogen level of 445 mg/dl (normal value: 200–450), and a D-dimer level of 865 μ/mm<span class="elsevierStyleSup">3</span> (normal value: 0–200). An abdominal computed tomographic image exhibited extrinsic compression of the ureter by a hypodense filling defect within the right ovarian vein, which is characteristic of ovarian vein thrombosis and grade III–IV hydronephrosis (<a class="elsevierStyleCrossRef" href="#f2-cln_65p452">Figures 2</a>, <a class="elsevierStyleCrossRef" href="#f3-cln_65p452">3</a>, and <a class="elsevierStyleCrossRef" href="#f4-cln_65p452">4</a>). Thus, the patient was treated with a low-molecular weight heparin coagulant (nadroparin 3800 IU, 0.6 ml every 12 h). Three days after the beginning of this therapy, color Doppler ultrasonography revealed a good vascular flow in right ovary, recanalization of the ovarian vein, and a reduction in the amount of fluid in the abdomen. At this point in time, the ureter was still dilated by extrinsic compression; however, a week later, ultrasonography showed normal-size ureter. The patient’s coagulation profile was within normal ranges in the following days.</p><elsevierMultimedia ident="f2-cln_65p452"></elsevierMultimedia><elsevierMultimedia ident="f3-cln_65p452"></elsevierMultimedia><elsevierMultimedia ident="f4-cln_65p452"></elsevierMultimedia></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">DISCUSSION</span><p id="para60" class="elsevierStylePara elsevierViewall">The pathophysiologies of preeclampsia and Mirror syndrome are not clearly understood. Various hypotheses as to the origins of these diseases have been explored, but none have provided exact explanations. Increased oxidative stress in the placental bed in combination with systemic maternal circulation is one of the most popular pathophysiological theories. Several factors that contribute to oxidative stress are plausible as explanations for the pathophysiology of preeclampsia</p><p id="para70" class="elsevierStylePara elsevierViewall">The first factor involves trophoblast invasion and the conversion of maternal spiral arteries into low-resistance vessels that are deficient in preeclampsia. As a result, a risk of residual vascular smooth muscle reactivity with resulting transient hypoxia is hypothesized, which results in an ischemia-reperfusion challenge and increased oxidative stress.<a class="elsevierStyleCrossRefs" href="#bib5">5,6</a> Second, debris from necrotic or apoptotic cells may provide proinflammatory stimuli, especially in the presence of a huge placenta mass, such as in the cases of multiple fetuses or molar pregnancy.<a class="elsevierStyleCrossRef" href="#bib3">3</a> We believe that this second mechanism is responsible for the observations made in this case.</p><p id="para80" class="elsevierStylePara elsevierViewall">In addition, the placental weight was 980 g, which was greater than expected, and there was diffuse hydropic degeneration, which may cause the deportation of more debris than usual to the maternal circulation. An increased inflammatory response to this debris may cause increased oxidative stress and endothelial dysfunction. Endothelial dysfunction results in three processes: impaired homeostasis, an increased risk of thrombosis, and impaired regulation of vascular tone, which clinically presents as hypertension. In fact, as early as 1958, the pathophysiology of preeclampsia was attributed to hyperplacentosis and hypoplacentosis.<a class="elsevierStyleCrossRef" href="#bib3">3</a> In certain types of preeclampsia, as in hydrops fetalis, hydatidiform mole, maternal diabetes, and possibly multiple pregnancies where the placental mass is also often large a state of hyperplacentosis appears to be an essential etiological factor. The main characteristics of hyperplacentosis include a large placental mass with a marked increase in the placental/fetal weight ratio, hydropic chorionic villi, overactivity and immaturity of the trophoblast, and persistence of the Langhans’ layer. In other types of preeclampsia, the placenta is small, underactive, and shows evidence of infarction and acceleration of the normal aging process with, presumably, a decrease in functional activity; these anomalies are grouped under the term of hypoplacentosis and generally accompany intrauterine growth retardation.<a class="elsevierStyleCrossRef" href="#bib3">3</a></p><p id="para90" class="elsevierStylePara elsevierViewall">Ovarian vein thrombosis is a rare, but well-recognized clinical entity that has the potential to cause severe complications. This problem most often occurs in the post-partum period; however, it can also arise in inflammatory disease, after abortion, in association with pre-term or cesarean deliveries, after hysterectomy/salpingo-oophorectomy, or in the setting of gynecological malignancy.<a class="elsevierStyleCrossRef" href="#bib7">7</a> Other risk factors include systemic lupus erythematosus, antiphospholipid syndrome, the presence of Factor V Leiden, paroxysmal nocturnal hemoglobinuria, hyperhomocysteinemia, C and S protein deficiencies, and heparin-induced thrombocytopenia.<a class="elsevierStyleCrossRef" href="#bib8">8</a>–<a class="elsevierStyleCrossRef" href="#bib10">10</a></p><p id="para100" class="elsevierStylePara elsevierViewall">OVT during pregnancy is a rare pathology that is characterized by inflammation or thrombosis of one or both ovarian veins. The pathogenesis of OVT during pregnancy is still not clearly understood. A state of hypercoagulability during pregnancy, an increased diameter of the ovarian vein, a decrease of blood flow velocity in the ovarian veins following delivery, and hereditary prothrombotic predisposition factors have been considered to be possible causes of OVT.<a class="elsevierStyleCrossRef" href="#bib4">4</a> As was true in the current case, 90% of OVT cases occur in the right ovarian vein. This predominant right localization is partly due to the dextrotorsion of the puerperal enlarged uterus, which causes compression of the ovarian vein or of the incompetent valves of the right ovarian vein that induce blood flow stasis. Furthermore, the right ovarian vein is also longer than the left, and its incompetent valves are a nidus for thrombosis.<a class="elsevierStyleCrossRef" href="#bib4">4</a></p><p id="para110" class="elsevierStylePara elsevierViewall">The clinical presentation of OVT is similar to that of acute appendicitis, wherein the latter is the suspected diagnosis in most cases. Fever is seen in 80%, right iliac fossa pain in 55%, and lower left quadrant pain in 3.6% of patients.<a class="elsevierStyleCrossRef" href="#bib11">11</a> In addition to appendicitis, OVT is often difficult to distinguish from endometritis, hydronephrosis, right-sided ureteral obstruction, hydronephritis, and other ovarian diseases, such as torsion. A high index of suspicion and the ability to rule out other processes that may produce similar symptoms is important, as untreated OVT can have catastrophic consequences and may even prove to be fatal.<a class="elsevierStyleCrossRef" href="#bib12">12</a></p><p id="para120" class="elsevierStylePara elsevierViewall">Our patient suffered from lower quadrant and flank pain without fever, as well as grade I hydronephrosis of the right kidney since 28 <span class="elsevierStyleSup">th</span> week of pregnancy. During the postpartum period, her complaint and grade of hydronephrosis was aggravated, and she exhibited a fever despite receiving a broad-spectrum antibiotic. Based on these data, we think that the process of ovarian vein thrombosis began during pregnancy and was aggravated after delivery. During the postpartum period, the question of a hereditary prothrombotic predisposition was explored in our case, but none was found; however, we strongly believe that the ovarian vein compression by the huge SCT, in addition to an enlarged uterus, increased the prothrombotic predisposition because preeclampsia may contribute to the existence of OVT.</p><p id="para130" class="elsevierStylePara elsevierViewall">After an extensive literature search, two cases that associated Mirror syndrome to SCT<a class="elsevierStyleCrossRefs" href="#bib1">1,13</a> and no cases of associations between Mirror syndrome, ovarian vein thrombosis, and SCT were found. Knowledge of these syndromes and clinical suspicion in pregnant patients, whose fetuses show hydrops fetalis, proteinuria, and hypertension, and in puerperal patients suffering from lower quadrant pain and fever (which alone does not respond to adequate broad-spectrum antibiotics), should serve as guides for appropriate diagnosis.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 1 => array:2 [ "identificador" => "cesec20" "titulo" => "CASE REPORT" ] 2 => array:2 [ "identificador" => "cesec30" "titulo" => "DISCUSSION" ] 3 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "f1-cln_65p452" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 320 "Ancho" => 423 "Tamanyo" => 29761 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">A view of the huge SCT and the fetus showing hydrops fetalis.</p>" ] ] 1 => array:7 [ "identificador" => "f2-cln_65p452" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 291 "Ancho" => 423 "Tamanyo" => 19900 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">A computed tomographic image that depicts the patient’s normal left ovarian vein (dashed arrow) and right, enlarged and thrombi-filled, ovarian vein (three solid arrows).</p>" ] ] 2 => array:7 [ "identificador" => "f3-cln_65p452" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 482 "Ancho" => 432 "Tamanyo" => 24194 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">A computed tomographic image that depicts the obstruction of the right ureter (thin arrow) by the enlarged right ovarian vein (thick dashed arrow).</p>" ] ] 3 => array:7 [ "identificador" => "f4-cln_65p452" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 287 "Ancho" => 422 "Tamanyo" => 20942 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Grade III–IV hydronephrosis (thick dashed arrow) and ureter obstruction (thin solid arrow).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mirror syndrome associated with sacrococcygeal teratoma: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ PS Finamore \n \t\t\t\t\t\t\t\t """ 1 => """ E Kontopoulos \n \t\t\t\t\t\t\t\t """ 2 => """ M Price \n \t\t\t\t\t\t\t\t """ 3 => """ G Giannina \n \t\t\t\t\t\t\t\t """ 4 => """ JC Smulian \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Reprod Med" "fecha" => "2007" "volumen" => "52" "paginaInicial" => "225" "paginaFinal" => "227" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17465292" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Mirror syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ DY Midgley \n \t\t\t\t\t\t\t\t """ 1 => """ K Harding \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0301-2115(99)00147-5" "Revista" => array:6 [ "tituloSerie" => "Eur J Obstet Gynecol Reprod Biol" "fecha" => "2000" "volumen" => "88" "paginaInicial" => "201" "paginaFinal" => "202" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10690681" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical biological features of Ballantyne syndrome and the role of placental hydrops" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ L Carbillon \n \t\t\t\t\t\t\t\t """ 1 => """ JF Oury \n \t\t\t\t\t\t\t\t """ 2 => """ JM Guerin \n \t\t\t\t\t\t\t\t """ 3 => """ A Azancot \n \t\t\t\t\t\t\t\t """ 4 => """ P Blot \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 1 | 6 |
| 2024 October | 22 | 17 | 39 |
| 2024 September | 23 | 9 | 32 |
| 2024 August | 27 | 18 | 45 |
| 2024 July | 24 | 25 | 49 |
| 2024 June | 12 | 2 | 14 |
| 2024 May | 29 | 12 | 41 |
| 2024 April | 18 | 8 | 26 |
| 2024 March | 20 | 17 | 37 |
| 2024 February | 69 | 17 | 86 |
| 2024 January | 30 | 15 | 45 |
| 2023 December | 10 | 12 | 22 |
| 2023 November | 12 | 24 | 36 |
| 2023 October | 11 | 27 | 38 |
| 2023 September | 12 | 21 | 33 |
| 2023 August | 6 | 13 | 19 |
| 2023 July | 7 | 14 | 21 |
| 2023 June | 15 | 6 | 21 |
| 2023 May | 25 | 1 | 26 |
| 2023 April | 28 | 3 | 31 |
| 2023 March | 21 | 4 | 25 |
| 2023 February | 12 | 2 | 14 |
| 2023 January | 3 | 3 | 6 |
| 2022 December | 29 | 7 | 36 |
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