Letters to the Editor
Fatal Bronchovascular Fistula after a Single Lung Transplantation: A Case Report
Marcos Naoyuki SamanoI, Juliana Akemi SakaI, Marlova Luzzi CaramoriII, Paulo Manuel Pêgo-FernandesI, Fabio Biscegli JateneI
I Thoracic Surgery Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brazil
II Pulmonology Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brazil., Tel.: 55 113069.5248
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Note the disruption of the anterior atlanto-occipital ligament, which connects the lower anterior clivus with the anterior aspect of the body of C2, <span class="elsevierStyleItalic">as visualized by the superior continuation of the anterior longitudinal ligament.</span> In addition, disruption of the anterior longitudinal ligament is evident (arrow-b). Note the dislocated atlas (arrow-c) and compression of the <span class="elsevierStyleItalic">dura mater</span> space. Line (d) represents the Wachenheim-clivus line (a method to evaluate craniocervical abnormalities). The line is drawn along the posterior aspect of the clivus, toward the odontoid process (OP). In normal subjects, the line is tangential to the posterior aspect of the OP. In contrast, in our patient, this line intersects the anterior aspect of the OP</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ali Al Kaissi, Klaus Klaushofer, Franz Grill" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Ali Al" "apellidos" => "Kaissi" ] 1 => array:2 [ "nombre" => "Klaus" "apellidos" => "Klaushofer" ] 2 => array:2 [ "nombre" => "Franz" "apellidos" => "Grill" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222025480?idApp=UINPBA00004N" "url" => "/18075932/0000006400000010/v1_202212060817/S1807593222025480/v1_202212060817/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222025467" "issn" => "18075932" "doi" => "10.1590/S1807-59322009001000014" "estado" => "S300" "fechaPublicacion" => "2009-10-01" "aid" => "20222546" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "rev" "cita" => "Clinics. 2009;64:1025-30" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Epidemiology of Human Infection with the Novel Virus Influenza A (H1H1) in the Hospital das Clínicas, São Paulo, Brazil – June–September 2009" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1025" "paginaFinal" => "1030" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f4-cln_64p1025" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 497 "Ancho" => 984 "Tamanyo" => 80899 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Distribution of reportable cases in the HC-FMUSP according to the local of attending - June 16 to September 18</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Denise Schout, Ludhmila Abrahao Hajjar, Filomena Regina Barbosa Gomes Galas, David Everson Uip, Anna Sara Shafferman Levin, Helio Hehl Caiaffa Filho, Pedro Takanori Sakane, Carlos Alberto Suslik, Jose Manoel de Camargo Teixeira, Eloisa Bonfa, Antonio Alci Barone, Milton de Arruda Martins, Marcos Boulos, Jose Otavio Costa Auler" "autores" => array:14 [ 0 => array:2 [ "nombre" => "Denise" "apellidos" => "Schout" ] 1 => array:2 [ "nombre" => "Ludhmila Abrahao" "apellidos" => "Hajjar" ] 2 => array:2 [ "nombre" => "Filomena Regina Barbosa Gomes" "apellidos" => "Galas" ] 3 => array:2 [ "nombre" => "David Everson" "apellidos" => "Uip" ] 4 => array:2 [ "nombre" => "Anna Sara Shafferman" "apellidos" => "Levin" ] 5 => array:2 [ "nombre" => "Helio Hehl Caiaffa" "apellidos" => "Filho" ] 6 => array:2 [ "nombre" => "Pedro Takanori" "apellidos" => "Sakane" ] 7 => array:2 [ "nombre" => "Carlos Alberto" "apellidos" => "Suslik" ] 8 => array:2 [ "nombre" => "Jose Manoel" "apellidos" => "de Camargo Teixeira" ] 9 => array:2 [ "nombre" => "Eloisa" "apellidos" => "Bonfa" ] 10 => array:2 [ "nombre" => "Antonio Alci" "apellidos" => "Barone" ] 11 => array:2 [ "nombre" => "Milton" "apellidos" => "de Arruda Martins" ] 12 => array:2 [ "nombre" => "Marcos" "apellidos" => "Boulos" ] 13 => array:3 [ "nombre" => "Jose Otavio Costa" "apellidos" => "Auler" "sufijo" => "Jr." ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222025467?idApp=UINPBA00004N" "url" => "/18075932/0000006400000010/v1_202212060817/S1807593222025467/v1_202212060817/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the Editor</span>" "titulo" => "Fatal Bronchovascular Fistula after a Single Lung Transplantation: A Case Report" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1031" "paginaFinal" => "1033" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Marcos Naoyuki Samano, Juliana Akemi Saka, Marlova Luzzi Caramori, Paulo Manuel Pêgo-Fernandes, Fabio Biscegli Jatene" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Marcos Naoyuki" "apellidos" => "Samano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "afI-cln_64p1031" ] ] ] 1 => array:3 [ "nombre" => "Juliana Akemi" "apellidos" => "Saka" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "afI-cln_64p1031" ] ] ] 2 => array:4 [ "nombre" => "Marlova Luzzi" "apellidos" => "Caramori" "email" => array:1 [ 0 => "marcos.samano@incor.usp.br" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "afII-cln_64p1031" ] ] ] 3 => array:3 [ "nombre" => "Paulo Manuel" "apellidos" => "Pêgo-Fernandes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "afI-cln_64p1031" ] ] ] 4 => array:3 [ "nombre" => "Fabio Biscegli" "apellidos" => "Jatene" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "afI-cln_64p1031" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Thoracic Surgery Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brazil" "etiqueta" => "I" "identificador" => "afI-cln_64p1031" ] 1 => array:3 [ "entidad" => "Pulmonology Division, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brazil., Tel.: 55 113069.5248" "etiqueta" => "II" "identificador" => "afII-cln_64p1031" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f3-cln_64p1031" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 745 "Ancho" => 994 "Tamanyo" => 112994 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Autopsy examination of the bronchovascular fistula orifice through the pulmonary artery</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Airway complications following bronchial anastomosis remain an important cause of morbidity and mortality in patients who undergo lung transplantation.<a class="elsevierStyleCrossRef" href="#bib1">1</a> The main complications associated with this procedure are airway stenosis, dehiscence and tissue granulation.<a class="elsevierStyleCrossRef" href="#bib2">2</a> Bronchovascular fistulas are a very rare but serious and fatal complication of altered bronchial anastomotic healing, which leads to massive hemoptysis and death in almost all cases. We report the first Brazilian case of fatal hemoptysis due to the formation of a bronchial fistula within the pulmonary artery during the early postoperative period of a left single-lung transplantation for idiopathic fibrosis.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">CASE DESCRIPTION</span><p id="para20" class="elsevierStylePara elsevierViewall">A 59-year-old male underwent a left single-lung transplant for idiopathic pulmonary fibrosis after being on a waiting list for 4 months. The operation was uneventful, with a total ischemic time of 170 minutes. Bronchial anastomosis was performed using a telescoping technique and with a continuous suture using 4-0 Prolene (Ethicon, Somerville, NJ) in the posterior membranous portion and invaginating “U” stitch sutures in the cartilaginous portion. The venous and arterial anastomoses were made with continuous sutures using 5-0 Prolene.</p><p id="para30" class="elsevierStylePara elsevierViewall">The patient was extubated after 12 hours of mechanical ventilation. The patient’s ICU length-of-stay was 14 days, and the total length-of-stay was 28 days. Initial immunosuppressive therapy included tacrolimus, prednisone and azathioprine, substituted 14 days later with mycophenolate mofetil, due to leukopenia. Prophylaxis against Cytomegalovirus and <span class="elsevierStyleItalic">P. carinii</span> was provided by treatment with ganciclovir and co-trimoxazole. The patient developed significant inflammatory infiltration in the left lung on the 14<span class="elsevierStyleSup">th</span> postoperative day. Transbronchial biopsy showed minimal rejection (grade A1) of the transplanted lung, and the patient was treated with methylprednisolone resulting in total recovery. A bronchoscopic evaluation also showed partial necrosis at the anastomotic site, but no signs of dehiscence (<a class="elsevierStyleCrossRef" href="#f1-cln_64p1031">Figure 1</a>).</p><elsevierMultimedia ident="f1-cln_64p1031"></elsevierMultimedia><p id="para40" class="elsevierStylePara elsevierViewall">Ten days after discharge, on the 38<span class="elsevierStyleSup">th</span> postoperative day, the patient had a massive hemoptysis and died of hypovolemic shock in the emergency room. An autopsy revealed a fistula between the pulmonary artery and the left main bronchus, which was identified as the cause of the massive hemoptysis (<a class="elsevierStyleCrossRefs" href="#f2-cln_64p1031">Figures 2 and 3</a>).</p><elsevierMultimedia ident="f3-cln_64p1031"></elsevierMultimedia><elsevierMultimedia ident="f2-cln_64p1031"></elsevierMultimedia><p id="para50" class="elsevierStylePara elsevierViewall">Analysis of bronchoalveolar lavage (BAL) fluid obtained shortly after the surgical procedure indicated the presence of <span class="elsevierStyleItalic">Serratia marcescens and Staphylococcus epidermidis.</span> Ten days later, analysis of sputum cultures revealed the presence of coagulase-positive <span class="elsevierStyleItalic">Staphylococcus</span>, <span class="elsevierStyleItalic">Corynebacterium sp.</span> and <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>. Antimicrobial therapy included second, third and fourth generation cephalosporins, amikacin, ciprofloxacin and imipenem. Although several tests for mycobacteria and fungi were performed from BAL and sputum samples, there was no evidence for the presence of such infections.</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">DISCUSSION</span><p id="para60" class="elsevierStylePara elsevierViewall">Fistulas between vascular structures and the tracheobronchial tree are a potentially fatal condition associated with hemoptysis.<a class="elsevierStyleCrossRefs" href="#bib3">3,4,5</a> The majority of these types of complications are related to general thoracic surgical procedures, especially aneurysms of the thoracic aorta.<a class="elsevierStyleCrossRef" href="#bib6">6</a> The appearance of bronchovascular fistulas after lung transplantation has been previously reported, but mainly in association with the pulmonary artery.<a class="elsevierStyleCrossRefs" href="#bib3">3,5,7</a> Knight et al.<a class="elsevierStyleCrossRef" href="#bib4">4</a> reported three cases of fatal bronchial fistulas occurring at the azygos vein and the descending aorta.</p><p id="para70" class="elsevierStylePara elsevierViewall">The treatment for this condition depends on early diagnosis and the correction of bronchial and vascular communication by restricting bleeding and avoiding hypovolemic shock.<a class="elsevierStyleCrossRefs" href="#bib7">7,8</a> If only one lung is affected, selective intubation is indicated in order to preserve the other lung by avoiding “blood drainage” and allowing some ventilation.</p><p id="para80" class="elsevierStylePara elsevierViewall">Surgical treatment is based on pneumonectomy or resection of the fistulas with reconstruction of the pulmonary artery and bronchial anastomosis; however, the morbimortality of this emergency procedure is excessively high, and its recommendation depends on the risks, underlying conditions and expected complications.<a class="elsevierStyleCrossRef" href="#bib8">8</a> Davidson et al.<a class="elsevierStyleCrossRef" href="#bib9">9</a> reported a case of a pulmonary artery-to-bronchial stump fistula after a right upper lobectomy that was successfully treated with endovascular placement of a covered stent. Management by endovascular stent placement has been primarily used for aortobronchial fistulas related to aneurysms or pseudoaneurysms of the descending thoracic aorta with successful occlusion.<a class="elsevierStyleCrossRefs" href="#bib10">10,11,12</a> Unfortunately, urgent treatment of our patient was not possible, and the patient died shortly after arriving in the emergency room.</p><p id="para90" class="elsevierStylePara elsevierViewall">Abnormal healing of the bronchus is the cornerstone for the occurrence of bronchial anastomotic complications, since deficient vascularization causes ischemia of the bronchial tree after anastomosis. Although bronchial artery anastomosis has been supported by some authors, it is technically complicated and ineffective.<a class="elsevierStyleCrossRef" href="#bib13">13</a> Other techniques, such as using a short donor-derived bronchial stump, reinforcement of the site of anastomosis with an omental flap, donor pericardium or intercostal muscle pedicle, and the use of a telescoping technique, have been shown to be more effective in promoting bronchial healing, improving the coverage of anastomosis and enhancing neovascularization.<a class="elsevierStyleCrossRefs" href="#bib14">14,15</a> The telescoping technique for bronchial anastomosis was introduced in order to minimize the risk of complications. In addition, this technique is especially useful when there are discrepancies in bronchial size between the recipient and donor.<a class="elsevierStyleCrossRef" href="#bib16">16</a> This technique was used in the first reported cases of bronchial anastomosis, including in the case presented here; however, end-to-end anastomosis is more often performed contemporarily. End-to-end anastomosis has been shown to be superior to the telescoping technique with respect to the incidence of complications, such as severe stenosis, ischemia and dehiscence.<a class="elsevierStyleCrossRefs" href="#bib17">17,18</a> However, there are no reports that consider the implications of end-to-end anastomosis on fistula formation.</p><p id="para100" class="elsevierStylePara elsevierViewall">Surveillance bronchoscopy allows for the direct evaluation of anastomosis healing and the appearance of related complications. When performed in conjunction with transbronchial biopsy and BAL, surveillance bronchoscopy can be a very important tool for patient follow-up after lung transplantation. This technique is also useful for the early diagnosis of infection by <span class="elsevierStyleItalic">Aspergillus</span> and for the identification of ulcerative and necrotizing defects of the airways.<a class="elsevierStyleCrossRef" href="#bib5">5</a> Unfortunately, in our patient, cultures of BAL and sputum specimens revealed no signs of fungal infection. Previous bronchoscopy revealed the presence of necrotic and granulated tissue around the site of anastomosis, but bronchoscopy was not able to identify the formation of a fistula. Fungal infection, or aspergillosis, is frequently associated with bronchial complications, such as stenosis, dehiscence and bronchovascular fistulas.<a class="elsevierStyleCrossRefs" href="#bib4">4,5,7,19</a> This infection increases the risk of morbimortality after lung transplantation, which varies according to the time of onset, the site of infection and the type of transplant procedure.<a class="elsevierStyleCrossRef" href="#bib20">20</a></p><p id="para110" class="elsevierStylePara elsevierViewall">Bronchovascular fistulas are a very dangerous complication of airway anastomoses. The type or form of treatment depends on early diagnosis and is based on re-operation or stent placement. Even though it is a very rare condition, improved evaluation of the factors that contribute to fistula formation must be developed and always considered during follow-up evaluations of lung transplant patients. In addition, surveillance bronchoscopy should be routinely performed in order to identify patients at risk for developing fistulas.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 1 => array:2 [ "identificador" => "cesec20" "titulo" => "CASE DESCRIPTION" ] 2 => array:2 [ "identificador" => "cesec30" "titulo" => "DISCUSSION" ] 3 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "f1-cln_64p1031" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 542 "Ancho" => 542 "Tamanyo" => 26481 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Endoscopic image of necrosis in the bronchial anastomosis</p>" ] ] 1 => array:7 [ "identificador" => "f2-cln_64p1031" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 745 "Ancho" => 994 "Tamanyo" => 139340 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Posterior view of the fistula orifice in the donor bronchus right below the anastomotic site</p>" ] ] 2 => array:7 [ "identificador" => "f3-cln_64p1031" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 745 "Ancho" => 994 "Tamanyo" => 112994 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Autopsy examination of the bronchovascular fistula orifice through the pulmonary artery</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early and late airway complications after lung transplantation: incidence and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ VR Kshettry \n \t\t\t\t\t\t\t\t """ 1 => """ TJ Kroshus \n \t\t\t\t\t\t\t\t """ 2 => """ MI Hertz \n \t\t\t\t\t\t\t\t """ 3 => """ DW Hunter \n \t\t\t\t\t\t\t\t """ 4 => """ SJ Shumway \n \t\t\t\t\t\t\t\t """ 5 => """ RM Bolman III \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0003-4975(97)83852-0" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "1997" "volumen" => "63" "paginaInicial" => "1576" "paginaFinal" => "1583" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9205151" "web" => 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| Year/Month | Html | Total | |
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