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      "cabecera" => "<span class="elsevierStyleTextfn">Clinical Sciences</span>"
      "titulo" => "Reasons for Resubmission of Research Projects to the Research Ethics Committee of a University Hospital in S&#195;O Paulo&#44; Brazil"
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          "autoresLista" => "Mariana Bueno, Maria Meimei Brevidelli, Tha&#237;s Cocarelli, Gianni Mara Silva dos Santos, Maria Auxiliadora Ferraz, D&#233;cio Mion"
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    "titulo" => "In The September 2009 Issue of Clinics"
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        "autoresLista" => "Mauricio Rocha-e-Silva"
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            "nombre" => "Mauricio"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para10" class="elsevierStylePara elsevierViewall">In this September 2009 issue of Clinics we highlight a study by Meneghini et al&#46; on the effect of Memantine&#44; a N-methyl-d-aspartate &#40;NMDA&#41; glutamate receptor antagonist used to treat Alzheimer&#8217;s disease on cardiomyocites&#46; They found that the reduction of nuclear size of rats exposed to a cold stress is effectively prevented by simultaneous treatment with memantine&#46; We publish nine papers on Clinical Science and three other reports on non clinical research&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">Bueno et al&#46; evaluated the reasons for resubmitting research projects to the Research Ethics Committee of a University Hospital in S&#227;o Paulo Brazil&#44; and found that the main reasons for returning the projects to the researchers were the use of inadequate language and&#47;or difficulty understanding the informed consent form&#44; lack of information about the protocol in the informed consent form&#44; as well as doubts regarding methodological and statistical issues of the protocol&#46; Otherreasons involved lack of accuracy or incomplete documentation&#44; need of clarification&#44; approval for participation of external entities&#44; and lack of information on financial support&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">Bittencourt et al&#46; evaluated HFE and non-HFE gene mutations in Brazilian patients with hereditary hemochromatosis and found that one-third of Brazilian subjects with the classical phenotype of HH do not carry HFE or other mutations that are currently associated with the disease in Caucasians&#46; This observation suggests a role for other yet unknown mutations in the aforementioned genes or in other genes involved in iron homeostasis in the pathogenesis of hereditary hemochromatosis in Brazil&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">Kamulegeya et al&#46; investigated the epidemiological characteristics of maxillofacial fractures and associated fractures in 132 patients seen in the Oral Surgery Unit of Mulago Hospital&#44; Kampala&#44; Uganda through a six-month prospective study&#44; which included socio-demographic factors&#44; type and etiology of injury&#44; additional fractures&#44; and post-surgery complications and recommend that anticipated changes in maxillofacial trauma trends necessitate regular epidemiologic studies of facial fractures to allow for development and implementation of timely novel preventive measures&#46;</p><p id="para50" class="elsevierStylePara elsevierViewall">Brand&#227;o et al&#46; followed 53 patients with medullar thyroid carcinoma&#44; a neoplasia of intermediate prognosis and differentiation&#44; which does not always respond predictably to known treatments&#46; They found that clinical and pathological aspects of surgically treated patients are predictors of disease progression&#46; Specifically&#44; even treated cervical lymph node metastases are significantly correlated with disease progression&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">Carvalho et al&#46; evaluated crack cocaine use practices&#44; risk behaviors associated with HIV infection among drug users&#44; and their involvement with violence in 350 drug users attending drug abuse treatment clinics in S&#227;o Paulo&#44; Brazil&#46; A high HIV prevalence and associated risky sexual behaviors were observed among crack cocaine users&#46; The society and the authorities that deal with violence related to crack users and drug trafficking should be aware of these problems&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">Campos et al&#46; endeavored to identify factors associated with increased levels of self-reported quality of life among HIV-infected patients after four months of antiretroviral therapy&#46; Patients were recruited at two public health referral centers for AIDS in the city of Belo Horizonte&#44; Brazil&#44; for a prospective adherence study&#46; Authors highlight the importance of modifiable factors such as psychiatric symptoms and treatment-related variables that may contribute to a better quality of life among patients initiating treatment&#46; Considering that poor quality of life is related to non-adherence to antiretroviral therapy&#44; careful clinical monitoring of these factors may contribute to ensuring the long-term effectiveness of antiretroviral regimens&#46;</p><p id="para80" class="elsevierStylePara elsevierViewall">Meyer et al&#46; evaluated&#44; by means of the Inflammatory Bowel Disease Questionnaire the quality of life of 36 ulcerative colitis patients submitted to proctocolectomy with sphincter preservation using J-pouch reconstruction over ten years ago&#46; They concluded that the possibility of sphincter preservation should always be taken into account&#44; since patients remain clinically stable and have a high quality of life even after long periods&#46;</p><p id="para90" class="elsevierStylePara elsevierViewall">Miot et al&#46; estimated oculometric parameters of 15 cases of Graves&#8217; ophthalmopathy in comparison to 12 healthy eyes using digital photography and digital image analysis&#46; This comparative analysis suggests that eye proptosis is related to an asymmetric increase in lateral oculometric measures&#44; and that standardized digital photographs can be used in clinical practice to objectively estimate oculometric parameters of Graves&#8217; ophthalmopathy patients&#46;</p><p id="para100" class="elsevierStylePara elsevierViewall">Vaz et al&#46; sought to identify the participation of the coagulation system in the differential diagnosis of pleural effusions through the laboratory profile of coagulation and fibrinolysis in 54 pleural fluids &#40;15 transudates and 39 exudates&#41;&#46; The coagulation system was found to play an important role in the development of pleural diseases&#46; Coagulation tests show differences between transudates and exudates but not among exudate subgroups&#46; Understanding the pathophysiological mechanisms of pleural disorders may help to define new diagnostic and therapeutic approaches&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">Pai et al&#46; studied 98 pelvic halves of embalmed cadavers&#44; in which the origin and course of the obturator artery were traced and noted&#46; The data obtained in this study show that it is more common to find an abnormal obturator artery than was reported previously&#44; and this observation has implications for pelvic surgeons and is of academic interest to anatomists&#46; Surgeons dealing with direct&#44; indirect&#44; femoral&#44; or obturator hernias need to be aware of these variations and their close proximity to the femoral ring&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">Cardoso et al&#46; identified the scientific production of tenured faculty from the Universidade de S&#227;o Paulo&#44; Faculdade de Medicina performed from 2001 to 2006&#44; and that it is possible to analyze this by the number of papers published by full professors&#44; taking into account not only their academic position and influence&#44; but also the fact that publication is an opportunity to stimulate joint projects with other members of the same institution&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">Zanoni et al&#46; investigated mesenteric microcirculatory dysfunctions&#44; bacterial translocation phenomenon&#44; and hemodynamic&#47;metabolic disturbances in a rat model of intestinal obstruction and ischemia&#46; They found that Intestinal obstruction and ischemia in rats is a relevant model for the in vivo study of mesenteric microcirculatory dysfunction and the occurrence of bacterial translocation&#46; This model parallels the events implicated in multiple organ dysfunction &#40;MOD&#41; and death&#46;</p><p id="para140" class="elsevierStylePara elsevierViewall">We also publish 3 case reports</p></span>"
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