Positron Emission Tomography With 2-[18F]-Fluoro-2-Deoxy-D-Glucose For Initial Staging Of Hodgkin Lymphoma: A Single Center Experience In Brazil

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LN (lymph node); RMB (right main bronchus); LMB (left main bronchus)" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Teresa Garrido, Fauze Maluf-Filho, Rubens A.A. Sallum, Viviane Rossi Figueiredo, Márcia Jacomelli, Miguel Tedde" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Teresa" "apellidos" => "Garrido" ] 1 => array:2 [ "nombre" => "Fauze" "apellidos" => "Maluf-Filho" ] 2 => array:2 [ "nombre" => "Rubens A.A." 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A) FDG-PET coronal, axial and maximum intensity projection (MIP) images showed additional splenic lesions (arrows) not observed in the CT axial image (1). B) After two ABVD cycles, all lesions, including the splenic foci, disappeared; normal CT axial image (2)." ] ] ] "textoCompleto" => "INTRODUCTIONOver the last several decades, the Hodgkin lymphoma (HL) cure rates have remained among the highest in oncologic patients, mainly due to the improvement of treatment strategies, which include chemotherapy and radiotherapy. A precise staging of HL patients is essential for selecting an appropriate treatment, as well as for determining the prognosis. The Ann-Arbor system modified in Cotswolds<a class="elsevierStyleCrossRef" href="#bib1">1</a> is widely used to define the conventional clinical stage (CCS) of HL patients.Conventional staging procedures include a physical examination, computed tomography (CT), and a bone marrow (BM) biopsy. Although CT provides important anatomic details, it cannot reliably distinguish between malignant and benign lesions because the definition of nodal or organ involvement is based only on morphological criteria. The correlation of CT findings with pathological staging demonstrated that the size of the lymph nodes was not always associated with the presence of HL.<a class="elsevierStyleCrossRef" href="#bib2">2</a> In addition, CT has a limited sensitivity for the detection of splenic, hepatic and bone marrow involvement. Therefore, the clinical staging of patients may be underestimated and thus lead to inappropriate therapy, or clinical staging may overestimate the severity and lead to overtreatment.In recent years, positron emission tomography (PET) with 2-[18F]-fluoro-2-Deoxy-D-glucose (FDG) has become an established modality for staging HL in the United States and Europe.<a class="elsevierStyleCrossRefs" href="#bib3">3–6</a> Besides HL staging, FDG-PET is also useful for evaluating the treatment response and the post-treatment remission status of HL patients, both of which are matters beyond the scope of this paper. Guidelines for its use in lymphomas were recently proposed by an international group.<a class="elsevierStyleCrossRef" href="#bib7">7</a> However, the spectrum of HL varies across different ethnic populations and environments, with different frequencies of Epstein Barr Virus detectable in the tumor, different grades of disease aggressiveness and later diagnoses. In developing countries, such as Brazil, the incidence of the advanced stages is considerably higher than in the United States and Europe.<a class="elsevierStyleCrossRef" href="#bib8">8</a> Although upstaging of the disease is the most common result when PET is integrated into the staging procedure, the performance of FDG-PET staging in populations with a high frequency of advanced HL stages is still unknown.MATERIAL AND METHODSPatientsEighty-two consecutive patients presenting newly diagnosed, biopsy proven, classical HL from the Hematology Division of the São Paulo University Clinics Hospital were eligible for this prospective study performed between August 2005 and January 2008. The only exclusion criterion was pregnancy. Notably, none of the patients had diabetes mellitus. The study was approved by the Ethical Board of the São Paulo University Clinics Hospital, and written informed consent was obtained from all participating patients.Conventional stagingAll patients were subjected to CCS procedures that included a physical examination, complete blood cell counts, blood chemistry analysis, CT scans (cervical, thoracic, abdomen and pelvic), and a bilateral BM biopsy. CT scans were sectioned at a thickness of 5 mm, and oral and intravenous contrast agents were administered to all patients. The nodal or organ involvement, as determined by CT, was defined by the modified Ann Arbor criteria.<a class="elsevierStyleCrossRef" href="#bib1">1</a> All patients had undergone a BM biopsy performed at the posterior iliac crest. Bone marrow involvement was defined as positive only for cases in which the presence of Reed-Sternberg cells or its variants were unequivocally observed. The CCS of each patient was assigned according to the Ann Arbor staging system.<a class="elsevierStyleCrossRef" href="#bib1">1</a>FDG-PET ImagingWhole-body PET images were acquired following a 60-minute uptake period after the intravenous administration of 296 to 444 MBq (8 to 12 mCi) of FDG. Imaging was then performed via 2-D acquisition with a GE Advance PET scanner (General Electric Medical Systems Advance; Milwaukee, Wisconsin, USA). Attenuation correction was performed using68 Ge sources. Prior to FDG administration, the fasting glucose level was measured in order to verify a blood glucose level < 160mg/dL. Diazepam was given orally to the majority of patients in order to avoid muscular and brown fat uptake.Visual interpretation of the images was performed independently by two experienced observers who were not aware of the CCS results. Areas of nonphysiological abnormalities increased the FDG uptake over the background and were classified as positive for the disease. Nodal and extranodal lymphoma involvement was defined according to the criteria established by the Consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma.<a class="elsevierStyleCrossRef" href="#bib7">7</a>The time between the staging CT and PET scan was no longer than two weeks.TreatmentAll patients were treated based on the CCS, regardless of the FDG-PET results. Stage I and II patients were treated with four to six cycles of the ABVD regimen (doxorubicin, bleomycin, vinblastine and dacarbazine). Stage III patients were treated with six to eight cycles of ABVD. Stage IV patients were treated with eight cycles of ABVD. Radiotherapy was included in all stage I or II patients and patients with bulky disease, regardless of their stage.Data analysisIn order to establish the diagnostic accuracy of the FDG-PET and the CT results obtained by both methods in all of the nodal regions and organs, these results had to be compared to a gold standard technique, such as histological examination. However, for obvious practical and ethical reasons, this was not possible. Instead of the histological gold standard, a reference standard was used for this analysis. The reference standard for all nodal regions and organs was obtained by combining the initial FDG-PET and CT results with the results of the FDG-PET performed after the second chemotherapy cycle and CT scans performed after the fourth cycle of chemotherapy. If the initial FDG-PET and CT scans were positive, the region was defined as a true positive for lymphoma involvement, while negative findings gleaned from both of these initial methods were regarded as a true negative. Discordant cases were retrospectively analyzed by an interdisciplinary team consisting of radiologists, nuclear physicians and hemato-oncologists. The status of a region or organ was determined using data from an interim FDG-PET performed after the second chemotherapy cycle, CT scans performed after the fourth cycle, CT and/or FDG-PET analyses obtained at the end of treatment, and, if available, a biopsy of the suspected lesion. For example, if a small lesion (< 1 cm) was radiologically normal and the PET positive lymph node changed to PET negative during follow-up scans, this lesion was labeled as “committed.” Alternatively, a large lymph node was considered “not committed” if it was PET negative and did not shrink during treatment while other enlarged nodes regressed and were PET negative at the end of treatment. To study BM involvement, the FDG-PET results were compared with the results of the bilateral BM biopsy. Notably, all of these patients had at least one year of follow-up evaluation after the completion of chemotherapy.In the analysis of clinical stage, the results of both methods were compared (CCS and FDG-PET alone). This analysis indicated that the PET would lead to a change in the clinical strategy if the patient stage moved from an early to advanced disease stage and vice-versa (either I or II up to III or IV or III or IV down to I or II).The diagnostic accuracies are given in terms of sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). SPSS 10.0 for Windows (SPSS Inc, Chicago, IL) was used for the statistical analysis.RESULTSPatientsOf the 82 patients evaluated, 40 were male. The median age at diagnosis was 32 years (16 to 82 years), and the most frequent histological subtype was nodular sclerosis, which was observed in 45 (54.8%) of the patients. The demographic and clinical characteristics of the patients as well as their corresponding CCS methods are listed in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>.<elsevierMultimedia ident="tbl1"></elsevierMultimedia>Staging accuracy in nodal sitesA total of 535 nodal regions had initial involvement according to the reference standard. CT scans could detect HL in 336 of the 535 regions analyzed, and FDG-PET detected involvement in 477 of the 535 regions. The observed frequency of nodal disease as a function of the site is listed in <a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>. The overall sensitivity, specificity, PPV and NPV for nodal staging of CT and FDG- PET/CT are provided in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>.<elsevierMultimedia ident="tbl2"></elsevierMultimedia><elsevierMultimedia ident="tbl4"></elsevierMultimedia>Staging accuracy in extranodal sitesThe spleen, liver, lungs, bone marrow/bone and soft tissue were evaluated. HL was observed in 43 of the 92 regions analyzed (46.7%) using CT and 86 of the 92 regions (93.4%) using FDG-PET. The frequency of involvement as a function of the site is listed in <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>. <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a> shows the sensitivity, specificity, PPV and NPV of the CT and the FDG-PET methods for detection of organ involvement.<elsevierMultimedia ident="tbl3"></elsevierMultimedia>PET Comparison to BM BiopsyOf the 82 patients, bilateral BM biopsy indicated marrow infiltration in 16 (19.5%) patients. Notably, all of these cases had multiple focal bone uptake of FDG, including the iliac crest region. Five other patients had a positive scan in the bone/BM as observed using FDG-PET in conjunction with negative BM biopsy results. Three patients had positive results in multiple bone/bone marrow areas including the posterior iliac crest FDG uptake, while one patient had a positive FDG uptake in multiple bone/BM areas but only limited uptake in the posterior iliac crest. The other patient had only one focal area of uptake located on a costal arch.Of the five patients with PET positive scans in the bone/BM, the latter case was considered as a false positive due to the fracture of a costal bone observed on the CT results. Regarding the former four patients, two had magnetic resonance imaging results indicating focal BM alterations compatible with lymphoma infiltration, while another patient had bone involvement detected on a bone scintigraphy. In all of these patients, the bone/BM FDG-avid lesions disappeared in the interim PET scan performed after the second cycle of chemotherapy.Change in clinical stage and therapyUpon comparison of both methods used in the staging of patients, the method that included the FDG-PET was concordant with CCS in 56 (68.2%) of the patients. In these concordant cases, additional committed lymph nodes were identified by FDG-PET in 48 (85.7%) of the patients. In 26 (31.7%) patients, the results obtained using FDG-PET scans were discordant with CCS. Seventeen patients (20.7%) were upstaged, while nine patients (10.9%) were downstaged. Of the seventeen upstaged patients, two moved from clinical stage I to II, one patient moved from stage I to IV, three patients moved from stage II to III, three patients moved from stage II to IV, and eight patients moved from stage III to IV. Of the nine downstaged patients, one moved from clinical stage II to I, four patients moved from stage III to II, one patient moved from stage IV to I, one patient moved from stage IV to II, and two patients moved from stage IV to III (<a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>).<elsevierMultimedia ident="tbl5"></elsevierMultimedia>If the FDG-PET results were included in the initial staging procedure, 13 (15.8%) of the 82 patients would have had a change in the therapy strategy. The status of seven patients would have been modified from early to advanced stages, and six patients would have been modified from advanced to early stages. Consequently these patients would have received a more or less aggressive treatment regimen, respectively (<a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>).As an example, <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a> shows images of a patient upstaged after FDG-PET analysis from stage II to III. The PET images demonstrated that FDG-PET positive foci in the spleen were not observed in the CT. While the biopsies of these lesions were not performed, the FDG positivity in the spleen disappeared when an early interim FDG-PET was completed after two cycles of chemotherapy (ABVD). Therefore, these images were considered FDG-PET true positive and CT false negative.<elsevierMultimedia ident="fig1"></elsevierMultimedia>DISCUSSIONThe reliability of FDG-PET in populations of different ethnic groups has not been investigated, as all studies published to date came from Western Europe and North America. In this unselected patient cohort, there was a high frequency of advanced stages of the disease, mainly stage IV (35.4% by conventional staging and 43.9% by FDG-PET). This particularly distinctive stage distribution provided an opportunity to compare the usefulness of FDG-PET with conventional methods not only for staging nodal regions but also for extranodal sites.Although the most important indication of FDG-PET is in the evaluation of the treatment response and post-treatment evaluation of HL, all of which are matters beyond the scope of this paper, FDG-PET may be used in the initial staging and may help classify patients into the appropriate stages of the disease, which can thus change the type and duration of the administered therapy.In this study, FDG-PET had a higher sensitivity than CT for the detection of nodal sites (87.8% vs. 61.6%, respectively), in agreement with other reports.<a class="elsevierStyleCrossRefs" href="#bib3">3–6</a>,<a class="elsevierStyleCrossRefs" href="#bib10">10–13</a> Metabolic testing with fluorine-18-fluorodeoxyglucose has also been described for detecting residual tumor or recurrence.<a class="elsevierStyleCrossRef" href="#bib14">14</a> The sensitivity of PET for detecting organ involvement was also higher than that determined for CT (96.2% vs. 40.0%, respectively), particularly for the evaluation of splenic involvement. The modified Ann-Arbor system indicates that spleen infiltration is positive only when palpable splenomegaly is present or when there is radiological evidence gleaned from the CT results that are indicative of the presence of multiple focal defects. For detecting spleen lesions, the higher PET sensitivity compared to CT is probably related to the ability of FDG-PET to detect metabolic changes in areas involved with HL before anatomical changes become visible.<a class="elsevierStyleCrossRef" href="#bib13">13</a>The diagnostic accuracy of FDG-PET for the detection of bone/BM involvement was also high when compared with results from the BM biopsy. FDG-PET identified all patients with a positive BM biopsy. In addition, another five patients were identified as positive using FDG-PET in bone/bone marrow sites but showed negative results in the BM biopsy. Only one of these discordant cases was considered as a false positive FDG-PET result due to the presence of a bone fracture. In all other discordant cases, the BM FDG-positive foci observed at staging disappeared during treatment. This discrepancy can be explained due to the existence of focal marrow infiltration by HL and biopsy sampling errors, even with bilateral sampling. As a consequence, the focal iliac BM involvement or infiltration at locations other than the posterior iliac crest could be missed by BM biopsy. Early studies have also demonstrated the usefulness of FDG-PET in the evaluation of BM involvement in lymphoma.<a class="elsevierStyleCrossRefs" href="#bib15">15–18</a> In a recent meta-analysis, a good correlation was demonstrated between the results from FDG-PET and the BM biopsy in regard to the detection of BM involvement during the staging of patients with malignant lymphoma. However, the study involved a mixed population of different lymphoma types that have distinct patterns of BM infiltration and FDG avidity.<a class="elsevierStyleCrossRef" href="#bib19">19</a> Therefore, there is no consensus in regard to the idea that FDG-PET significantly reduces the need for BM biopsies as an initial staging procedure in HL stages II to IV.<a class="elsevierStyleCrossRef" href="#bib7">7</a>Computed tomography is the most commonly used imaging modality for staging HL due to its widespread availability and relatively low cost.<a class="elsevierStyleCrossRef" href="#bib12">12</a> Therefore, CT remains the standard imaging modality for initial staging of malignant lymphoma. However, an important limitation of CT is its failure to detect pathological changes in normal-sized structures and lesions that have poor contrast with the surrounding tissue. An additional drawback of CT is that this method is not reliable for the detection of BM disease.<a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib20">20</a>Within recent years, FDG-PET has become the most important nuclear medicine and radiology imaging modality in the management of lymphoma. FDG-PET detects more disease sites and involved organs than conventional staging procedures, including CT, and it has a large influence on staging.<a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib20">20</a>,<a class="elsevierStyleCrossRef" href="#bib21">21</a>The major drawback of all studies that invoke FDG-PET analyses for the staging of HL is the absence of a histological confirmation of all the FDG-avid lesions, which then requires the use of a reference standard instead of the gold standard. This limitation must also be considered in our study, due to the possibility of biasing the results in favor of PET. Consequently, caution must be invoked for cases that are upstaged by FDG-PET because it is well known that benign processes may cause FDG uptake, such as rebound thymic hyperplasia, infection, inflammation and muscular or brown fat uptake.<a class="elsevierStyleCrossRef" href="#bib7">7</a> It is also important to consider the normal bio-distribution of FDG and the lack of anatomical detail of PET scans alone. The FDG-PET/CT fusion, using a combined PET/CT scanner, provides an accurate coregistration between the two modalities, allows for optimal interpretation of both modalities, and produces more accurate localization of the foci with increased FDG uptake than the stand-alone PET; this fusion may reduce the problems of physiological FDG uptake being misinterpreted as pathological and false localization of the disease.<a class="elsevierStyleCrossRef" href="#bib12">12</a> However, the results of this study are similar to the studies reported using PET/CT equipment.<a class="elsevierStyleCrossRef" href="#bib9">9</a>Another limitation of the current study is the analysis of a patient population from a single health center. Several authors have extensively studied the performance of PET and PET/CT compared with CT over the past five years; as such, the compilation of multiple studies with larger series is required to substantiate literature results.Besides the abovementioned limitations, numerous investigations have focused on the prospective impact of FDG-PET on staging and the choice of therapy in HL.<a class="elsevierStyleCrossRef" href="#bib19">19</a> These studies show that 11 to 41% of patients are upstaged by FDG-PET compared with conventional staging procedures and that 0 to 28% of patients are downstaged.The proportion of patients for whom the FDG-PET findings would potentially have changed the treatment strategy ranges from 3 to 25%. Similar to these aforementioned results, this study of a Brazilian population with a high rate of advanced stages of disease that have already been established by conventional methods indicates that 20.7% of these patients would have been upstaged and 10.9% would have been downstaged by implementation of the FDG-PET. If the stage were defined using the FDG-PET results, it would have led to a change in the treatment strategy in 15.8% (13/82) of the patients, whereby seven patients would have received more aggressive treatment strategies and six patients would have received less aggressive treatment strategies.CONCLUSIONThe results of the present study indicate that FDG-PET has a high accuracy for the detection of nodal and extranodal HL and is superior to CT analysis alone. In addition, an excellent sensitivity for the detection of BM disease was observed using FDG-PET. The detection of additional lesions using FDG-PET imaging improves the accuracy of HL staging. Even in a Brazilian population that is characterized by a high rate of advanced stages of the disease using conventional methods, the FDG-PET most often upstages the disease and leads to a change in the treatment strategy in a significant number (16%) of patients. However, changes in the clinical stage based only upon FDG-PET results should be performed with caution, and subsequent biopsy of the site in question may be necessary depending on the clinical context. The results of the modification of HL therapy based on initial FDG-PET findings are still an open question that will only be answered with controlled clinical trials." "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "xpalclavsec1584853" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIAL AND METHODS" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Conventional staging" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "FDG-PET Imaging" ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "Treatment" ] 4 => array:2 [ "identificador" => "cesec70" "titulo" => "Data analysis" ] ] ] 3 => array:3 [ "identificador" => "cesec80" "titulo" => "RESULTS" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "cesec90" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "cesec100" "titulo" => "Staging accuracy in nodal sites" ] 2 => array:2 [ "identificador" => "cesec110" "titulo" => "Staging accuracy in extranodal sites" ] 3 => array:2 [ "identificador" => "cesec120" "titulo" => "PET Comparison to BM Biopsy" ] 4 => array:2 [ "identificador" => "cesec130" "titulo" => "Change in clinical stage and therapy" ] ] ] 4 => array:2 [ "identificador" => "cesec140" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec150" "titulo" => "CONCLUSION" ] 6 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-01-29" "fechaAceptado" => "2009-03-02" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1584853" "palabras" => array:5 [ 0 => "FDG-PET" 1 => "computed tomography" 2 => "Hodgkin" 3 => "lymphoma" 4 => "initial staging" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "BACKGROUND:2-[18F]-Fluoro-2-Deoxy-D-Glucose (FDG-PET) is a well established functional imaging modality for the initial staging of Hodgkin lymphoma (HL) in patients from Western Europe and North America. The reliability of FDG-PET in populations of different ethnic groups is unclear, as all investigations published to date have come from developed countries. PURPOSE:The aim of the present study was to investigate the effectiveness of FDG-PET in the initial staging of HL patients in a Brazilian population. METHODS:Eighty-two patients with newly diagnosed HL were prospectively included in the study. All patients were staged with both conventional clinical staging (CCS) methods, including computed tomography (CT) and whole-body FDG-PET methods. A standard of reference for the nodal regions and the extranodal organs was determined using all available information, including the CCS methods, FDG-PET, the diagnostic histology and the follow-up examinations. The results of the CCS were then compared to the FDG-PET results. RESULTS:The sensitivity of FDG-PET was higher for nodal staging than that of CT (87.8% vs. 61.6%, respectively). FDG-PET was also more sensitive than CT in regard to evaluating the extranodal organs for lymphomatous involvement (96.2% vs. 40.0%, respectively). FDG-PET detected all 16 patients who were characterized by a positive bone marrow biopsy and identified an additional 4 patients with bone marrow disease. The incorporation of FDG-PET coupled with CCS in the staging procedure upstaged 20% (17/82) of the patients and downstaged 11% (9/82) of the patients. As a result of these changes in staging, 15% (13/82) of the patients would have received a different therapeutic regimen. CONCLUSIONS:The FDG-PET method is superior to CT for the detection of nodal and extra-nodal HL. The observation that the FDG-PET method upstaged the disease was the most common result (20% of patients) brought about by the addition of PET to the staging algorithm, even in a population of patients with a high incidence of advanced disease. However, changes in stages based on FDG-PET results should be confirmed by biopsy." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "BACKGROUND:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "PURPOSE:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "METHODS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "RESULTS:" ] 4 => array:2 [ "identificador" => "ceabs50" "titulo" => "CONCLUSIONS:" ] ] ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1 -" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1534 "Ancho" => 2044 "Tamanyo" => 169006 ] ] "descripcion" => array:1 [ "en" => "A 22-year old male patient with conventional clinical stage II disease. A) FDG-PET coronal, axial and maximum intensity projection (MIP) images showed additional splenic lesions (arrows) not observed in the CT axial image (1). B) After two ABVD cycles, all lesions, including the splenic foci, disappeared; normal CT axial image (2)." ] ] 1 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1 -" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Characteristics \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">N = 82 (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="bottom">Sex</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">42 (51.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">40 (48.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Age – median (range) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">32 (16 to 82) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="bottom">Race</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">White \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">39 (47.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Black \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">2 (0.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">1 (0.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Mixed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">40 (48.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="bottom">Pathological subtype</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Nodular sclerosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">45 (54.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Mixed cellularity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">22 (26.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Lymphocyte rich \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">3 (3.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Lymphocyte-depleted \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">3 (3.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Not classified \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">9 (11.0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="bottom">Ann Arbor Clinical Stage</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">8 (9.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">23 (28.0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">22 (26.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">29 (35.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">B Symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">50 (60.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Bulky Disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">48 (58.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Demographic and clinical characteristics of the Hodgkin’s lymphoma patients" ] ] 2 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2 -" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Sites \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Reference Standard \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">FDG-PET \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">TC \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Cervical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">66 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Supraclavicular \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">107 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">68 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Mediastinal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">65 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Axillarys \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">42 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Pulmonar Hilar \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">24 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Paraortic/Mesenteric \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">42 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Iliac \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Inguinal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Others \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom" style="border-bottom: 2px solid black">TOTAL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">535 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">477 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">336 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Region-based analysis of lymph nodes sites using CT and FDG-PET in 82 patients during the initial staging" ] ] 3 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 3 -" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Sites \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Reference Standard \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">FDG-PET \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">TC \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Lungs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">22 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Spleen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">14 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Liver \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Bone/Bone Marrow<a class="elsevierStyleCrossRef" href="#tfn1">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Soft Tissue \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom" style="border-bottom: 2px solid black">TOTAL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">43 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn1" "etiqueta" => "*" "nota" => "Bones includes bone marrow involvement." ] ] ] "descripcion" => array:1 [ "en" => "Region-based analysis of extranodal sites using CT and FDG-PET in 82 patients during initial staging" ] ] 4 => array:7 [ "identificador" => "tbl4" "etiqueta" => "Table 4 -" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="middle" scope="col">Nodal sites</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="middle" scope="col">Extranodal sites</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">PET \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">TC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">PET \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">TC \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Sensitivity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">87.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">61.6% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">96.2% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">40.0% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">Specificity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">98.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">99.0% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">99.5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">98.7% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">PPV<a class="elsevierStyleCrossRef" href="#tfn2">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">98.5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">98.2% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">97.4% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">86.4% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">NPV<a class="elsevierStyleCrossRef" href="#tfn2">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">90.3% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">74.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">99.2% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">86.4% \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn2" "etiqueta" => "*" "nota" => "PPV: positive predictive value; NPV: negative predictive value." ] ] ] "descripcion" => array:1 [ "en" => "Assessment of the overall accuracy rates using CT and FDG-PET on nodal and extranodal sites" ] ] 5 => array:7 [ "identificador" => "tbl5" "etiqueta" => "Table 5 -" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">PET Stage I \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">PET Stage II \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">PET Stage III \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">PET Stage IV \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Total CCS Stage (nº of cases) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">CCS Stage I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">I (8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">CCS Stage II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">II (23) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">CCS Stage III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">III (22) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom">CCS Stage IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom">IV (29) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="bottom" style="border-bottom: 2px solid black">Total PET Stage (n° of cases) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">I (7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">II (23) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">III (15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">IV (37) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="bottom" style="border-bottom: 2px solid black">82 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Initial staging distribution for Conventional Clinical Staging (CCS) and FDG-PET according to the Ann Arbor staging system and the corresponding up- and down-staging" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ TA Lister \n \t\t\t\t\t\t\t\t """ 1 => """ D Crowther \n \t\t\t\t\t\t\t\t """ 2 => """ SB Sutcliffe \n \t\t\t\t\t\t\t\t """ 3 => """ E Glatstein \n \t\t\t\t\t\t\t\t """ 4 => """ GP Canellos \n \t\t\t\t\t\t\t\t """ 5 => """ RC Young \n 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Clinical Science

Juliano Julio CerciI,

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juliano.cerci@incor.usp.br

Tel : 55 11 3069-5091

, Luís Fernando PracchiaII, José Soares JuniorI, Camila da Cruz Gouveia LinardiII, José Claudio MeneghettiI, Valeria BuccheriII

I Serviço de Radioisótopos do Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brasil

II Serviço de Hematologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP - Brasil

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Over the last several decades&#44; the Hodgkin lymphoma &#40;HL&#41; cure rates have remained among the highest in oncologic patients&#44; mainly due to the improvement of treatment strategies&#44; which include chemotherapy and radiotherapy&#46; A precise staging of HL patients is essential for selecting an appropriate treatment&#44; as well as for determining the prognosis&#46; The Ann-Arbor system modified in Cotswolds<a class="elsevierStyleCrossRef" href="#bib1">1</a> is widely used to define the conventional clinical stage &#40;CCS&#41; of HL patients&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">Conventional staging procedures include a physical examination&#44; computed tomography &#40;CT&#41;&#44; and a bone marrow &#40;BM&#41; biopsy&#46; Although CT provides important anatomic details&#44; it cannot reliably distinguish between malignant and benign lesions because the definition of nodal or organ involvement is based only on morphological criteria&#46; The correlation of CT findings with pathological staging demonstrated that the size of the lymph nodes was not always associated with the presence of HL&#46;<a class="elsevierStyleCrossRef" href="#bib2">2</a> In addition&#44; CT has a limited sensitivity for the detection of splenic&#44; hepatic and bone marrow involvement&#46; Therefore&#44; the clinical staging of patients may be underestimated and thus lead to inappropriate therapy&#44; or clinical staging may overestimate the severity and lead to overtreatment&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">In recent years&#44; positron emission tomography &#40;PET&#41; with 2-&#91;18F&#93;-fluoro-2-Deoxy-D-glucose &#40;FDG&#41; has become an established modality for staging HL in the United States and Europe&#46;<a class="elsevierStyleCrossRefs" href="#bib3">3&#8211;6</a> Besides HL staging&#44; FDG-PET is also useful for evaluating the treatment response and the post-treatment remission status of HL patients&#44; both of which are matters beyond the scope of this paper&#46; Guidelines for its use in lymphomas were recently proposed by an international group&#46;<a class="elsevierStyleCrossRef" href="#bib7">7</a> However&#44; the spectrum of HL varies across different ethnic populations and environments&#44; with different frequencies of Epstein Barr Virus detectable in the tumor&#44; different grades of disease aggressiveness and later diagnoses&#46; In developing countries&#44; such as Brazil&#44; the incidence of the advanced stages is considerably higher than in the United States and Europe&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a> Although upstaging of the disease is the most common result when PET is integrated into the staging procedure&#44; the performance of FDG-PET staging in populations with a high frequency of advanced HL stages is still unknown&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">MATERIAL AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Patients</span><p id="para40" class="elsevierStylePara elsevierViewall">Eighty-two consecutive patients presenting newly diagnosed&#44; biopsy proven&#44; classical HL from the Hematology Division of the S&#227;o Paulo University Clinics Hospital were eligible for this prospective study performed between August 2005 and January 2008&#46; The only exclusion criterion was pregnancy&#46; Notably&#44; none of the patients had diabetes mellitus&#46; The study was approved by the Ethical Board of the S&#227;o Paulo University Clinics Hospital&#44; and written informed consent was obtained from all participating patients&#46;</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Conventional staging</span><p id="para50" class="elsevierStylePara elsevierViewall">All patients were subjected to CCS procedures that included a physical examination&#44; complete blood cell counts&#44; blood chemistry analysis&#44; CT scans &#40;cervical&#44; thoracic&#44; abdomen and pelvic&#41;&#44; and a bilateral BM biopsy&#46; CT scans were sectioned at a thickness of 5 mm&#44; and oral and intravenous contrast agents were administered to all patients&#46; The nodal or organ involvement&#44; as determined by CT&#44; was defined by the modified Ann Arbor criteria&#46;<a class="elsevierStyleCrossRef" href="#bib1">1</a> All patients had undergone a BM biopsy performed at the posterior iliac crest&#46; Bone marrow involvement was defined as positive only for cases in which the presence of Reed-Sternberg cells or its variants were unequivocally observed&#46; The CCS of each patient was assigned according to the Ann Arbor staging system&#46;<a class="elsevierStyleCrossRef" href="#bib1">1</a></p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">FDG-PET Imaging</span><p id="para60" class="elsevierStylePara elsevierViewall">Whole-body PET images were acquired following a 60-minute uptake period after the intravenous administration of 296 to 444 MBq &#40;8 to 12 mCi&#41; of FDG&#46; Imaging was then performed via 2-D acquisition with a GE Advance PET scanner &#40;General Electric Medical Systems Advance&#59; Milwaukee&#44; Wisconsin&#44; USA&#41;&#46; Attenuation correction was performed using<span class="elsevierStyleSup">68</span> Ge sources&#46; Prior to FDG administration&#44; the fasting glucose level was measured in order to verify a blood glucose level &#60; 160mg&#47;dL&#46; Diazepam was given orally to the majority of patients in order to avoid muscular and brown fat uptake&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">Visual interpretation of the images was performed independently by two experienced observers who were not aware of the CCS results&#46; Areas of nonphysiological abnormalities increased the FDG uptake over the background and were classified as positive for the disease&#46; Nodal and extranodal lymphoma involvement was defined according to the criteria established by the Consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma&#46;<a class="elsevierStyleCrossRef" href="#bib7">7</a></p><p id="para80" class="elsevierStylePara elsevierViewall">The time between the staging CT and PET scan was no longer than two weeks&#46;</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">Treatment</span><p id="para90" class="elsevierStylePara elsevierViewall">All patients were treated based on the CCS&#44; regardless of the FDG-PET results&#46; Stage I and II patients were treated with four to six cycles of the ABVD regimen &#40;doxorubicin&#44; bleomycin&#44; vinblastine and dacarbazine&#41;&#46; Stage III patients were treated with six to eight cycles of ABVD&#46; Stage IV patients were treated with eight cycles of ABVD&#46; Radiotherapy was included in all stage I or II patients and patients with bulky disease&#44; regardless of their stage&#46;</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Data analysis</span><p id="para100" class="elsevierStylePara elsevierViewall">In order to establish the diagnostic accuracy of the FDG-PET and the CT results obtained by both methods in all of the nodal regions and organs&#44; these results had to be compared to a gold standard technique&#44; such as histological examination&#46; However&#44; for obvious practical and ethical reasons&#44; this was not possible&#46; Instead of the histological gold standard&#44; a reference standard was used for this analysis&#46; The reference standard for all nodal regions and organs was obtained by combining the initial FDG-PET and CT results with the results of the FDG-PET performed after the second chemotherapy cycle and CT scans performed after the fourth cycle of chemotherapy&#46; If the initial FDG-PET and CT scans were positive&#44; the region was defined as a true positive for lymphoma involvement&#44; while negative findings gleaned from both of these initial methods were regarded as a true negative&#46; Discordant cases were retrospectively analyzed by an interdisciplinary team consisting of radiologists&#44; nuclear physicians and hemato-oncologists&#46; The status of a region or organ was determined using data from an interim FDG-PET performed after the second chemotherapy cycle&#44; CT scans performed after the fourth cycle&#44; CT and&#47;or FDG-PET analyses obtained at the end of treatment&#44; and&#44; if available&#44; a biopsy of the suspected lesion&#46; For example&#44; if a small lesion &#40;&#60; 1 cm&#41; was radiologically normal and the PET positive lymph node changed to PET negative during follow-up scans&#44; this lesion was labeled as &#8220;committed&#46;&#8221; Alternatively&#44; a large lymph node was considered &#8220;not committed&#8221; if it was PET negative and did not shrink during treatment while other enlarged nodes regressed and were PET negative at the end of treatment&#46; To study BM involvement&#44; the FDG-PET results were compared with the results of the bilateral BM biopsy&#46; Notably&#44; all of these patients had at least one year of follow-up evaluation after the completion of chemotherapy&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">In the analysis of clinical stage&#44; the results of both methods were compared &#40;CCS and FDG-PET alone&#41;&#46; This analysis indicated that the PET would lead to a change in the clinical strategy if the patient stage moved from an early to advanced disease stage and vice-versa &#40;either I or II up to III or IV or III or IV down to I or II&#41;&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">The diagnostic accuracies are given in terms of sensitivity&#44; specificity&#44; positive predictive value &#40;PPV&#41;&#44; and negative predictive value &#40;NPV&#41;&#46; SPSS 10&#46;0 for Windows &#40;SPSS Inc&#44; Chicago&#44; IL&#41; was used for the statistical analysis&#46;</p></span></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">RESULTS</span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">Patients</span><p id="para130" class="elsevierStylePara elsevierViewall">Of the 82 patients evaluated&#44; 40 were male&#46; The median age at diagnosis was 32 years &#40;16 to 82 years&#41;&#44; and the most frequent histological subtype was nodular sclerosis&#44; which was observed in 45 &#40;54&#46;8&#37;&#41; of the patients&#46; The demographic and clinical characteristics of the patients as well as their corresponding CCS methods are listed in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia></span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle160">Staging accuracy in nodal sites</span><p id="para140" class="elsevierStylePara elsevierViewall">A total of 535 nodal regions had initial involvement according to the reference standard&#46; CT scans could detect HL in 336 of the 535 regions analyzed&#44; and FDG-PET detected involvement in 477 of the 535 regions&#46; The observed frequency of nodal disease as a function of the site is listed in <a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#46; The overall sensitivity&#44; specificity&#44; PPV and NPV for nodal staging of CT and FDG- PET&#47;CT are provided in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><elsevierMultimedia ident="tbl4"></elsevierMultimedia></span><span id="cesec110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle170">Staging accuracy in extranodal sites</span><p id="para150" class="elsevierStylePara elsevierViewall">The spleen&#44; liver&#44; lungs&#44; bone marrow&#47;bone and soft tissue were evaluated&#46; HL was observed in 43 of the 92 regions analyzed &#40;46&#46;7&#37;&#41; using CT and 86 of the 92 regions &#40;93&#46;4&#37;&#41; using FDG-PET&#46; The frequency of involvement as a function of the site is listed in <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>&#46; <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a> shows the sensitivity&#44; specificity&#44; PPV and NPV of the CT and the FDG-PET methods for detection of organ involvement&#46;</p><elsevierMultimedia ident="tbl3"></elsevierMultimedia></span><span id="cesec120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle180">PET Comparison to BM Biopsy</span><p id="para160" class="elsevierStylePara elsevierViewall">Of the 82 patients&#44; bilateral BM biopsy indicated marrow infiltration in 16 &#40;19&#46;5&#37;&#41; patients&#46; Notably&#44; all of these cases had multiple focal bone uptake of FDG&#44; including the iliac crest region&#46; Five other patients had a positive scan in the bone&#47;BM as observed using FDG-PET in conjunction with negative BM biopsy results&#46; Three patients had positive results in multiple bone&#47;bone marrow areas including the posterior iliac crest FDG uptake&#44; while one patient had a positive FDG uptake in multiple bone&#47;BM areas but only limited uptake in the posterior iliac crest&#46; The other patient had only one focal area of uptake located on a costal arch&#46;</p><p id="para170" class="elsevierStylePara elsevierViewall">Of the five patients with PET positive scans in the bone&#47;BM&#44; the latter case was considered as a false positive due to the fracture of a costal bone observed on the CT results&#46; Regarding the former four patients&#44; two had magnetic resonance imaging results indicating focal BM alterations compatible with lymphoma infiltration&#44; while another patient had bone involvement detected on a bone scintigraphy&#46; In all of these patients&#44; the bone&#47;BM FDG-avid lesions disappeared in the interim PET scan performed after the second cycle of chemotherapy&#46;</p></span><span id="cesec130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle190">Change in clinical stage and therapy</span><p id="para180" class="elsevierStylePara elsevierViewall">Upon comparison of both methods used in the staging of patients&#44; the method that included the FDG-PET was concordant with CCS in 56 &#40;68&#46;2&#37;&#41; of the patients&#46; In these concordant cases&#44; additional committed lymph nodes were identified by FDG-PET in 48 &#40;85&#46;7&#37;&#41; of the patients&#46; In 26 &#40;31&#46;7&#37;&#41; patients&#44; the results obtained using FDG-PET scans were discordant with CCS&#46; Seventeen patients &#40;20&#46;7&#37;&#41; were upstaged&#44; while nine patients &#40;10&#46;9&#37;&#41; were downstaged&#46; Of the seventeen upstaged patients&#44; two moved from clinical stage I to II&#44; one patient moved from stage I to IV&#44; three patients moved from stage II to III&#44; three patients moved from stage II to IV&#44; and eight patients moved from stage III to IV&#46; Of the nine downstaged patients&#44; one moved from clinical stage II to I&#44; four patients moved from stage III to II&#44; one patient moved from stage IV to I&#44; one patient moved from stage IV to II&#44; and two patients moved from stage IV to III &#40;<a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl5"></elsevierMultimedia><p id="para190" class="elsevierStylePara elsevierViewall">If the FDG-PET results were included in the initial staging procedure&#44; 13 &#40;15&#46;8&#37;&#41; of the 82 patients would have had a change in the therapy strategy&#46; The status of seven patients would have been modified from early to advanced stages&#44; and six patients would have been modified from advanced to early stages&#46; Consequently these patients would have received a more or less aggressive treatment regimen&#44; respectively &#40;<a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>&#41;&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">As an example&#44; <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a> shows images of a patient upstaged after FDG-PET analysis from stage II to III&#46; The PET images demonstrated that FDG-PET positive foci in the spleen were not observed in the CT&#46; While the biopsies of these lesions were not performed&#44; the FDG positivity in the spleen disappeared when an early interim FDG-PET was completed after two cycles of chemotherapy &#40;ABVD&#41;&#46; Therefore&#44; these images were considered FDG-PET true positive and CT false negative&#46;</p><elsevierMultimedia ident="fig1"></elsevierMultimedia></span></span><span id="cesec140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle200">DISCUSSION</span><p id="para210" class="elsevierStylePara elsevierViewall">The reliability of FDG-PET in populations of different ethnic groups has not been investigated&#44; as all studies published to date came from Western Europe and North America&#46; In this unselected patient cohort&#44; there was a high frequency of advanced stages of the disease&#44; mainly stage IV &#40;35&#46;4&#37; by conventional staging and 43&#46;9&#37; by FDG-PET&#41;&#46; This particularly distinctive stage distribution provided an opportunity to compare the usefulness of FDG-PET with conventional methods not only for staging nodal regions but also for extranodal sites&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall">Although the most important indication of FDG-PET is in the evaluation of the treatment response and post-treatment evaluation of HL&#44; all of which are matters beyond the scope of this paper&#44; FDG-PET may be used in the initial staging and may help classify patients into the appropriate stages of the disease&#44; which can thus change the type and duration of the administered therapy&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">In this study&#44; FDG-PET had a higher sensitivity than CT for the detection of nodal sites &#40;87&#46;8&#37; vs&#46; 61&#46;6&#37;&#44; respectively&#41;&#44; in agreement with other reports&#46;<a class="elsevierStyleCrossRefs" href="#bib3">3&#8211;6</a>&#44;<a class="elsevierStyleCrossRefs" href="#bib10">10&#8211;13</a> Metabolic testing with fluorine-18-fluorodeoxyglucose has also been described for detecting residual tumor or recurrence&#46;<a class="elsevierStyleCrossRef" href="#bib14">14</a> The sensitivity of PET for detecting organ involvement was also higher than that determined for CT &#40;96&#46;2&#37; vs&#46; 40&#46;0&#37;&#44; respectively&#41;&#44; particularly for the evaluation of splenic involvement&#46; The modified Ann-Arbor system indicates that spleen infiltration is positive only when palpable splenomegaly is present or when there is radiological evidence gleaned from the CT results that are indicative of the presence of multiple focal defects&#46; For detecting spleen lesions&#44; the higher PET sensitivity compared to CT is probably related to the ability of FDG-PET to detect metabolic changes in areas involved with HL before anatomical changes become visible&#46;<a class="elsevierStyleCrossRef" href="#bib13">13</a></p><p id="para240" class="elsevierStylePara elsevierViewall">The diagnostic accuracy of FDG-PET for the detection of bone&#47;BM involvement was also high when compared with results from the BM biopsy&#46; FDG-PET identified all patients with a positive BM biopsy&#46; In addition&#44; another five patients were identified as positive using FDG-PET in bone&#47;bone marrow sites but showed negative results in the BM biopsy&#46; Only one of these discordant cases was considered as a false positive FDG-PET result due to the presence of a bone fracture&#46; In all other discordant cases&#44; the BM FDG-positive foci observed at staging disappeared during treatment&#46; This discrepancy can be explained due to the existence of focal marrow infiltration by HL and biopsy sampling errors&#44; even with bilateral sampling&#46; As a consequence&#44; the focal iliac BM involvement or infiltration at locations other than the posterior iliac crest could be missed by BM biopsy&#46; Early studies have also demonstrated the usefulness of FDG-PET in the evaluation of BM involvement in lymphoma&#46;<a class="elsevierStyleCrossRefs" href="#bib15">15&#8211;18</a> In a recent meta-analysis&#44; a good correlation was demonstrated between the results from FDG-PET and the BM biopsy in regard to the detection of BM involvement during the staging of patients with malignant lymphoma&#46; However&#44; the study involved a mixed population of different lymphoma types that have distinct patterns of BM infiltration and FDG avidity&#46;<a class="elsevierStyleCrossRef" href="#bib19">19</a> Therefore&#44; there is no consensus in regard to the idea that FDG-PET significantly reduces the need for BM biopsies as an initial staging procedure in HL stages II to IV&#46;<a class="elsevierStyleCrossRef" href="#bib7">7</a></p><p id="para250" class="elsevierStylePara elsevierViewall">Computed tomography is the most commonly used imaging modality for staging HL due to its widespread availability and relatively low cost&#46;<a class="elsevierStyleCrossRef" href="#bib12">12</a> Therefore&#44; CT remains the standard imaging modality for initial staging of malignant lymphoma&#46; However&#44; an important limitation of CT is its failure to detect pathological changes in normal-sized structures and lesions that have poor contrast with the surrounding tissue&#46; An additional drawback of CT is that this method is not reliable for the detection of BM disease&#46;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib20">20</a></p><p id="para260" class="elsevierStylePara elsevierViewall">Within recent years&#44; FDG-PET has become the most important nuclear medicine and radiology imaging modality in the management of lymphoma&#46; FDG-PET detects more disease sites and involved organs than conventional staging procedures&#44; including CT&#44; and it has a large influence on staging&#46;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#44;<a class="elsevierStyleCrossRef" href="#bib21">21</a></p><p id="para270" class="elsevierStylePara elsevierViewall">The major drawback of all studies that invoke FDG-PET analyses for the staging of HL is the absence of a histological confirmation of all the FDG-avid lesions&#44; which then requires the use of a reference standard instead of the gold standard&#46; This limitation must also be considered in our study&#44; due to the possibility of biasing the results in favor of PET&#46; Consequently&#44; caution must be invoked for cases that are upstaged by FDG-PET because it is well known that benign processes may cause FDG uptake&#44; such as rebound thymic hyperplasia&#44; infection&#44; inflammation and muscular or brown fat uptake&#46;<a class="elsevierStyleCrossRef" href="#bib7">7</a> It is also important to consider the normal bio-distribution of FDG and the lack of anatomical detail of PET scans alone&#46; The FDG-PET&#47;CT fusion&#44; using a combined PET&#47;CT scanner&#44; provides an accurate coregistration between the two modalities&#44; allows for optimal interpretation of both modalities&#44; and produces more accurate localization of the foci with increased FDG uptake than the stand-alone PET&#59; this fusion may reduce the problems of physiological FDG uptake being misinterpreted as pathological and false localization of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib12">12</a> However&#44; the results of this study are similar to the studies reported using PET&#47;CT equipment&#46;<a class="elsevierStyleCrossRef" href="#bib9">9</a></p><p id="para280" class="elsevierStylePara elsevierViewall">Another limitation of the current study is the analysis of a patient population from a single health center&#46; Several authors have extensively studied the performance of PET and PET&#47;CT compared with CT over the past five years&#59; as such&#44; the compilation of multiple studies with larger series is required to substantiate literature results&#46;</p><p id="para290" class="elsevierStylePara elsevierViewall">Besides the abovementioned limitations&#44; numerous investigations have focused on the prospective impact of FDG-PET on staging and the choice of therapy in HL&#46;<a class="elsevierStyleCrossRef" href="#bib19">19</a> These studies show that 11 to 41&#37; of patients are upstaged by FDG-PET compared with conventional staging procedures and that 0 to 28&#37; of patients are downstaged&#46;</p><p id="para300" class="elsevierStylePara elsevierViewall">The proportion of patients for whom the FDG-PET findings would potentially have changed the treatment strategy ranges from 3 to 25&#37;&#46; Similar to these aforementioned results&#44; this study of a Brazilian population with a high rate of advanced stages of disease that have already been established by conventional methods indicates that 20&#46;7&#37; of these patients would have been upstaged and 10&#46;9&#37; would have been downstaged by implementation of the FDG-PET&#46; If the stage were defined using the FDG-PET results&#44; it would have led to a change in the treatment strategy in 15&#46;8&#37; &#40;13&#47;82&#41; of the patients&#44; whereby seven patients would have received more aggressive treatment strategies and six patients would have received less aggressive treatment strategies&#46;</p></span><span id="cesec150" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle210">CONCLUSION</span><p id="para310" class="elsevierStylePara elsevierViewall">The results of the present study indicate that FDG-PET has a high accuracy for the detection of nodal and extranodal HL and is superior to CT analysis alone&#46; In addition&#44; an excellent sensitivity for the detection of BM disease was observed using FDG-PET&#46; The detection of additional lesions using FDG-PET imaging improves the accuracy of HL staging&#46; Even in a Brazilian population that is characterized by a high rate of advanced stages of the disease using conventional methods&#44; the FDG-PET most often upstages the disease and leads to a change in the treatment strategy in a significant number &#40;16&#37;&#41; of patients&#46; However&#44; changes in the clinical stage based only upon FDG-PET results should be performed with caution&#44; and subsequent biopsy of the site in question may be necessary depending on the clinical context&#46; The results of the modification of HL therapy based on initial FDG-PET findings are still an open question that will only be answered with controlled clinical trials&#46;</p></span></span>"
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    "resumen" => array:1 [
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        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">BACKGROUND&#58;</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">2-&#91;18F&#93;-Fluoro-2-Deoxy-D-Glucose &#40;FDG-PET&#41; is a well established functional imaging modality for the initial staging of Hodgkin lymphoma &#40;HL&#41; in patients from Western Europe and North America&#46; The reliability of FDG-PET in populations of different ethnic groups is unclear&#44; as all investigations published to date have come from developed countries&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">PURPOSE&#58;</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">The aim of the present study was to investigate the effectiveness of FDG-PET in the initial staging of HL patients in a Brazilian population&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">METHODS&#58;</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">Eighty-two patients with newly diagnosed HL were prospectively included in the study&#46; All patients were staged with both conventional clinical staging &#40;CCS&#41; methods&#44; including computed tomography &#40;CT&#41; and whole-body FDG-PET methods&#46; A standard of reference for the nodal regions and the extranodal organs was determined using all available information&#44; including the CCS methods&#44; FDG-PET&#44; the diagnostic histology and the follow-up examinations&#46; The results of the CCS were then compared to the FDG-PET results&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">RESULTS&#58;</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">The sensitivity of FDG-PET was higher for nodal staging than that of CT &#40;87&#46;8&#37; vs&#46; 61&#46;6&#37;&#44; respectively&#41;&#46; FDG-PET was also more sensitive than CT in regard to evaluating the extranodal organs for lymphomatous involvement &#40;96&#46;2&#37; vs&#46; 40&#46;0&#37;&#44; respectively&#41;&#46; FDG-PET detected all 16 patients who were characterized by a positive bone marrow biopsy and identified an additional 4 patients with bone marrow disease&#46; The incorporation of FDG-PET coupled with CCS in the staging procedure upstaged 20&#37; &#40;17&#47;82&#41; of the patients and downstaged 11&#37; &#40;9&#47;82&#41; of the patients&#46; As a result of these changes in staging&#44; 15&#37; &#40;13&#47;82&#41; of the patients would have received a different therapeutic regimen&#46;</p></span> <span id="ceabs50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">CONCLUSIONS&#58;</span><p id="spara110" class="elsevierStyleSimplePara elsevierViewall">The FDG-PET method is superior to CT for the detection of nodal and extra-nodal HL&#46; The observation that the FDG-PET method upstaged the disease was the most common result &#40;20&#37; of patients&#41; brought about by the addition of PET to the staging algorithm&#44; even in a population of patients with a high incidence of advanced disease&#46; However&#44; changes in stages based on FDG-PET results should be confirmed by biopsy&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "BACKGROUND&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "PURPOSE&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "METHODS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "RESULTS&#58;"
          ]
          4 => array:2 [
            "identificador" => "ceabs50"
            "titulo" => "CONCLUSIONS&#58;"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig1"
        "etiqueta" => "Figure 1 -"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1534
            "Ancho" => 2044
            "Tamanyo" => 169006
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">A 22-year old male patient with conventional clinical stage II disease&#46; A&#41; FDG-PET coronal&#44; axial and maximum intensity projection &#40;MIP&#41; images showed additional splenic lesions &#40;arrows&#41; not observed in the CT axial image &#40;1&#41;&#46; B&#41; After two ABVD cycles&#44; all lesions&#44; including the splenic foci&#44; disappeared&#59; normal CT axial image &#40;2&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl1"
        "etiqueta" => "Table 1 -"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col"><span class="elsevierStyleBold">Characteristics</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col"><span class="elsevierStyleBold">N &#61; 82 &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="bottom"><span class="elsevierStyleBold">Sex</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">42</span> &#40;51&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">40</span> &#40;48&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">Age &#8211; median &#40;range&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">32</span> &#40;16 to 82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="bottom"><span class="elsevierStyleBold">Race</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">39</span> &#40;47&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Black&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">2</span> &#40;0&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Asian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">1</span> &#40;0&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Mixed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">40</span> &#40;48&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="bottom"><span class="elsevierStyleBold">Pathological subtype</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Nodular sclerosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">45</span> &#40;54&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Mixed cellularity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">22</span> &#40;26&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Lymphocyte rich&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">3</span> &#40;3&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Lymphocyte-depleted&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">3</span> &#40;3&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Not classified&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">9</span> &#40;11&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="bottom"><span class="elsevierStyleBold">Ann Arbor Clinical Stage</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">8</span> &#40;9&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">23</span> &#40;28&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">22</span> &#40;26&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">29</span> &#40;35&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">B Symptoms</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">50</span> &#40;60&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">Bulky Disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleBold">48</span> &#40;58&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Demographic and clinical characteristics of the Hodgkin&#8217;s lymphoma patients</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl2"
        "etiqueta" => "Table 2 -"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col">Sites&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Reference Standard&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">FDG-PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Cervical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">113&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Supraclavicular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Mediastinal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Axillarys&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Pulmonar Hilar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Paraortic&#47;Mesenteric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Iliac&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Inguinal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">TOTAL</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">535</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">477</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">336</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Region-based analysis of lymph nodes sites using CT and FDG-PET in 82 patients during the initial staging</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl3"
        "etiqueta" => "Table 3 -"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col">Sites&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Reference Standard&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">FDG-PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Lungs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Spleen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Liver&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Bone&#47;Bone Marrow<a class="elsevierStyleCrossRef" href="#tfn1">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Soft Tissue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">TOTAL</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">92</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">86</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">43</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tfn1"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">Bones includes bone marrow involvement&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Region-based analysis of extranodal sites using CT and FDG-PET in 82 patients during initial staging</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl4"
        "etiqueta" => "Table 4 -"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="middle" scope="col">Nodal sites</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="middle" scope="col">Extranodal sites</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">PET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Sensitivity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">87&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">61&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">96&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">40&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Specificity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">98&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">99&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">99&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">98&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">PPV<a class="elsevierStyleCrossRef" href="#tfn2">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">98&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">98&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">97&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">86&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">NPV<a class="elsevierStyleCrossRef" href="#tfn2">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">90&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">74&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">99&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">86&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tfn2"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">PPV&#58; positive predictive value&#59; NPV&#58; negative predictive value&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Assessment of the overall accuracy rates using CT and FDG-PET on nodal and extranodal sites</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl5"
        "etiqueta" => "Table 5 -"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">PET Stage I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">PET Stage II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">PET Stage III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">PET Stage IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Total CCS Stage &#40;n&#186; of cases&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">CCS Stage I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom"><span class="elsevierStyleBold">5</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">I &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">CCS Stage II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom"><span class="elsevierStyleBold">16</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">II &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">CCS Stage III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom"><span class="elsevierStyleBold">10</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">III &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">CCS Stage IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom"><span class="elsevierStyleBold">25</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom">IV &#40;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom" style="border-bottom: 2px solid black">Total PET Stage &#40;n&#176; of cases&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black">I &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black">II &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black">III &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black">IV &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="bottom" style="border-bottom: 2px solid black">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Initial staging distribution for Conventional Clinical Staging &#40;CCS&#41; and FDG-PET according to the Ann Arbor staging system and the corresponding up- and down-staging</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
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Article information

ISSN: 18075932
Original language: English

DOI:10.1590/S1807-59322009000600002

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