metricas
covid
Buscar en
Clinics
Toda la web
Inicio Clinics Effects of the Histamine H2 Receptor Antagonist Famotidine on the Healing of Col...
Journal Information

Statistics

Follow this link to access the full text of the article

Clinical Science
Effects of the Histamine H2 Receptor Antagonist Famotidine on the Healing of Colonic Anastomosis in Rats
Aydın İnan, Meral Şen
Corresponding author
aydininan@ttmail.com

Tel: +90 312 2035555
, Önder Sürgit, Metin Ergin, Mikdat Bozer
Fatih University School of Medicine - Ankara, Türkiye
Read
726
Times
was read the article
308
Total PDF
418
Total HTML
Share statistics
 array:24 [
  "pii" => "S1807593222026163"
  "issn" => "18075932"
  "doi" => "10.1590/S1807-59322009000600012"
  "estado" => "S300"
  "fechaPublicacion" => "2009-06-01"
  "aid" => "2616"
  "copyright" => "CLINICS"
  "copyrightAnyo" => "2009"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
  "subdocumento" => "fla"
  "cita" => "Clinics. 2009;64:567-70"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1807593222026175"
    "issn" => "18075932"
    "doi" => "10.1590/S1807-59322009000600013"
    "estado" => "S300"
    "fechaPublicacion" => "2009-06-01"
    "aid" => "2617"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2009;64:571-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>"
      "titulo" => "Assessing the Scientific Research Productivity of a Brazilian Healthcare Institution&#58; A Case Study at the Heart Institute of S&#227;o Paulo&#44; Brazil"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "571"
          "paginaFinal" => "576"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Beatriz Helena Tess, S&#233;rgio Shiguemi Furuie, Regina C&#233;lia Figueiredo Castro, Maria do Carmo Cavarette Barreto, Moacyr Roberto Cuce Nobre"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Beatriz Helena"
              "apellidos" => "Tess"
            ]
            1 => array:2 [
              "nombre" => "S&#233;rgio Shiguemi"
              "apellidos" => "Furuie"
            ]
            2 => array:2 [
              "nombre" => "Regina C&#233;lia Figueiredo"
              "apellidos" => "Castro"
            ]
            3 => array:2 [
              "nombre" => "Maria"
              "apellidos" => "do Carmo Cavarette Barreto"
            ]
            4 => array:2 [
              "nombre" => "Moacyr Roberto Cuce"
              "apellidos" => "Nobre"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222026175?idApp=UINPBA00004N"
    "url" => "/18075932/0000006400000006/v1_202212060747/S1807593222026175/v1_202212060747/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1807593222026151"
    "issn" => "18075932"
    "doi" => "10.1590/S1807-59322009000600011"
    "estado" => "S300"
    "fechaPublicacion" => "2009-06-01"
    "aid" => "2615"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2009;64:561-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>"
      "titulo" => "Radio Frequency Electromagnetic Radiation &#40;RF-EMR&#41; from GSM &#40;0&#46;9&#47;1&#46;8GHZ&#41; Mobile Phones Induces Oxidative Stress and Reduces Sperm Motility in Rats"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "561"
          "paginaFinal" => "565"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Figure 1 -"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1672
              "Ancho" => 761
              "Tamanyo" => 50209
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Sperm count&#46; A&#46;</span> Total sperm count&#46; No significant difference was observed in the total sperm counts for the control &#40;group I&#41; and RF-EMR exposed rats &#40;group II&#41;&#46; <span class="elsevierStyleBold">B&#46;</span> Percent of motile sperm&#46; RF-EMR from a mobile phone significantly reduced the percentage of motile sperm in group II&#46; The results are expressed as the mean &#177; standard deviation of six epididymides from six rats&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maneesh Mailankot, Anil P Kunnath, H Jayalekshmi, Bhargav Koduru, Rohith Valsalan"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Maneesh"
              "apellidos" => "Mailankot"
            ]
            1 => array:2 [
              "nombre" => "Anil P"
              "apellidos" => "Kunnath"
            ]
            2 => array:2 [
              "nombre" => "H"
              "apellidos" => "Jayalekshmi"
            ]
            3 => array:2 [
              "nombre" => "Bhargav"
              "apellidos" => "Koduru"
            ]
            4 => array:2 [
              "nombre" => "Rohith"
              "apellidos" => "Valsalan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222026151?idApp=UINPBA00004N"
    "url" => "/18075932/0000006400000006/v1_202212060747/S1807593222026151/v1_202212060747/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>"
    "titulo" => "Effects of the Histamine H2 Receptor Antagonist Famotidine on the Healing of Colonic Anastomosis in Rats"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "567"
        "paginaFinal" => "570"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ayd&#305;n &#304;nan, Meral &#350;en, &#214;nder S&#252;rgit, Metin Ergin, Mikdat Bozer"
        "autores" => array:5 [
          0 => array:2 [
            "nombre" => "Ayd&#305;n"
            "apellidos" => "&#304;nan"
          ]
          1 => array:4 [
            "nombre" => "Meral"
            "apellidos" => "&#350;en"
            "email" => array:1 [
              0 => "aydininan@ttmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "c1"
              ]
            ]
          ]
          2 => array:2 [
            "nombre" => "&#214;nder"
            "apellidos" => "S&#252;rgit"
          ]
          3 => array:2 [
            "nombre" => "Metin"
            "apellidos" => "Ergin"
          ]
          4 => array:2 [
            "nombre" => "Mikdat"
            "apellidos" => "Bozer"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Fatih University School of Medicine - Ankara&#44; T&#252;rkiye"
            "identificador" => "af1"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "c1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Tel&#58; &#43;90 312 2035555"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Anastomotic leakage is a serious complication in colorectal surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib1">1&#8211;3</a> Leakage rates vary greatly and are associated with 0 to 30&#37; of all cases&#46; Clinically apparent leakage rates are between 2&#46;1 and 14&#46;9&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#44;<a class="elsevierStyleCrossRef" href="#bib2">2</a> Failure of anastomotic healing is associated with increased duration of hospital stay&#44; morbidity and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib2">2&#8211;4</a> At least one-third of deaths following colorectal surgery are attributed to anastomotic leakage&#44; although the reduction in the incidence of anastomotic dehiscence is due to contributing factors such as advances in perioperative care&#44; bowel preparation&#44; and surgical techniques&#46;<a class="elsevierStyleCrossRef" href="#bib3">3</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Healing of colon anastomoses involves a complex interaction of peptide growth factors and collagen turnover through the phases of inflammation&#44; fibroplasias&#44; and maturation&#46;<a class="elsevierStyleCrossRefs" href="#bib5">5&#8211;7</a></p><p id="para30" class="elsevierStylePara elsevierViewall">Histamine plays an important role in immune reactions&#44; in the coagulation cascade&#44; and in various related inflammatory reactions&#46; Histamine H2 receptors accelerate cell proliferation&#44; thereby impacting both lymphocyte and immune system response&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib9">9</a></p><p id="para40" class="elsevierStylePara elsevierViewall">Acid suppressive drugs &#40;H2 receptor antagonists and proton pump inhibitors&#41; are used for the prevention and treatment of stress-related mucosal diseases and other acid-related disorders&#46;<a class="elsevierStyleCrossRef" href="#bib10">10</a></p><p id="para50" class="elsevierStylePara elsevierViewall">In the context of these histamine-induced effects&#44; we decided to examine the effects of famotidine&#44; an H2 receptor antagonist&#44; on the healing of the anastomosis of the colon&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">METHODS</span><p id="para60" class="elsevierStylePara elsevierViewall">Twenty-eight Sprague-Dawley male rats weighing 230&#8211;255 g were used in this experiment&#46; A biostatistician was consulted to determine the appropriate number of rats per group&#46; The animals had free access to water and were fed standard rodent chow throughout the experiment&#46; Rats were housed for one week prior to surgical intervention&#46; The Ethics Committee of Fatih University Medical School approved the experiment&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">All animals were anesthetized by subcutaneous injection of 30 mL&#47;kg ketamine &#40;Ketalar&#44; Eczac&#305;ba&#351;i&#44; T&#252;rkiye&#41;&#46; The abdomen was shaved and prepared using povidone-iodine and a sterile dressing&#46; A laparotomy was performed with a 2 cm lower midline incision&#46; An end-to-end anastomosis was performed after excision of a 0&#46;5 cm segment of the distal colon&#44; 3 cm proximal to the peritoneal reflection&#46; Ten to twelve interrupted 6&#47;0 polypropylene &#40;Prolene&#44; Ethicon&#41; inverting sutures were used in the anastomosis&#46; The abdominal fascia was closed with 3&#47;0 continuous polyglactine &#40;Polysorb&#44; Tyco&#41; sutures&#44; and the skin was closed with 4&#47;0 polyglactine &#40;Polysorb&#44; Tyco&#41; in a subcuticular manner&#46;</p><p id="para80" class="elsevierStylePara elsevierViewall">The animals were randomly assigned to two groups&#46; The Famotidine Group &#40;14 rats&#41; received 2 mg&#47;kg&#47;day &#40;0&#46;5 mL&#47;kg&#47;day&#41; famotidine &#40;Nevofam-L amp&#44; Mustafa Nevzat&#41;&#44; while the Control Group &#40;14 rats&#41; received the same amount of saline subcutaneously&#46; This dose of famotidine is almost equivalent to double the maximal dose used clinically&#46; The justification for this dose selection was to more clearly elicit the possible effects of famotidine&#46; Following surgery&#44; the rats were allowed free access to water and resumed standard feeding&#46;</p><p id="para90" class="elsevierStylePara elsevierViewall">Seven rats from each group were randomly selected to assess the bursting pressure and hydroxyproline content of anastomosis on the third day following surgery&#46; The remaining seven rats from each group underwent the same procedure on the seventh day following surgery&#46;</p><p id="para100" class="elsevierStylePara elsevierViewall">After anesthesia was maintained with 30 mL&#47;kg Ketamine&#44; the abdomen was opened&#44; and the whole colon was resected&#46; Great attention was paid to preserve the adhesions&#46; Wide resections were performed when necessary&#46; The proximal colon was attached to a continuous pressure monitoring system with a transducer &#40;Peta&#351;&#44; KMA365B&#41; and supplied with air &#40;1 mL&#47;minute&#41; with an air pump&#46; The distal colon was occluded&#46; The entire colon was immersed in saline&#44; and the air pump was activated&#46; The maximum pressure before bubbles were seen was recorded as the bursting pressure for each rat&#46; After the bursting pressure was determined&#44; the perianastomotic region was cleared&#46; A 1-cm colon segment &#40;0&#46;5 cm from each side of the anastomosis&#41; was resected for hydroxyproline determination and stored at &#8722;40&#176;C&#46; Hydroxyproline content determinations of the samples were performed as described by Jamall et al&#46;<a class="elsevierStyleCrossRef" href="#bib11">11</a></p><p id="para110" class="elsevierStylePara elsevierViewall">SPSS for Windows&#174; 10&#46;0 was used for the statistical analysis&#46; Differences between groups in terms of bursting pressure and hydroxyproline content were assessed using a Mann-Whitney <span class="elsevierStyleItalic">U</span> test&#46; The statistical significance was set to p&#60;0&#46;05&#46;</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">RESULTS</span><p id="para120" class="elsevierStylePara elsevierViewall">The effects of famotidine on healing of a colonic anastomosis were examined in rats&#46; All rats survived the experiment&#44; and all anastomoses were intact on both the third and seventh days post surgery&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">Recorded bursting pressures for the Famotidine Group were significantly lower than those for the Control Group on both the third and seventh days post surgery &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#41;&#46; The mean hydroxyproline content was significantly lower for the Famotidine Group than for the Control Group &#40;<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><elsevierMultimedia ident="tbl2"></elsevierMultimedia></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">DISCUSSION</span><p id="para140" class="elsevierStylePara elsevierViewall">Wound healing is a complex cascade of overlapping events that depends on a number of cellular mechanisms and signaling pathways&#46; It requires the coordinated completion of a variety of cellular activities that include phagocytosis&#44; chemotaxis&#44; migration&#44; proliferation&#44; adhesion and differentiation&#46; The end result is synthesis and cross-linking of collagen and remodeling of the connective tissue&#46;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#44;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib13">13</a> The process of anastomotic healing is similar to observations in the skin&#46;<a class="elsevierStyleCrossRef" href="#bib14">14</a> The inflammatory phase is essential for healing&#44; with hemostasis preceding inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib15">15</a> Any factor that disrupts one or more steps in the healing process will likely result in impaired anastomotic healing&#46;<a class="elsevierStyleCrossRef" href="#bib16">16</a> Anastomotic dehiscence is a serious complication that causes significant morbidity and mortality in colorectal surgery&#46;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#44;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#44;<a class="elsevierStyleCrossRef" href="#bib17">17</a></p><p id="para150" class="elsevierStylePara elsevierViewall">Bursting pressure and hydroxyproline determinations are measures that offer insight into the anastomosis healing process&#46;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#44;<a class="elsevierStyleCrossRefs" href="#bib18">18&#8211;20</a> Bursting pressure reveals the mechanical parameters of a colonic anastomosis and reflects growing anastomotic strength&#46; Biochemical parameters of anastomotic healing are reflected by the collagen content in perianastomotic tissues&#44; as determined by hydroxyproline content&#46;<a class="elsevierStyleCrossRef" href="#bib19">19</a> In our experiments&#44; we measured the bursting pressure of the anastomosis and the hydroxyproline levels of the perianastomotic tissue to determine healing rates&#46;</p><p id="para160" class="elsevierStylePara elsevierViewall">Histamine significantly influences healing&#46;<a class="elsevierStyleCrossRef" href="#bib21">21</a> Histamine is one of the regulators of mesenteric blood flow&#44; leading to vasodilatation and increasing the regional blood flow in the mesentery<a class="elsevierStyleCrossRef" href="#bib22">22</a>&#46; Histamine offers homeostatic control of the circulation under both normal and pathologic conditions and causes vasodilatation of the intestine&#46;<a class="elsevierStyleCrossRef" href="#bib23">23</a> H2 receptor antagonists inhibit the vasodilatory effects of histamine&#46;<a class="elsevierStyleCrossRef" href="#bib22">22</a> However&#44; blood supply is one of the determinants of anastomotic healing and is of paramount importance&#46;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#44;<a class="elsevierStyleCrossRef" href="#bib25">25</a></p><p id="para170" class="elsevierStylePara elsevierViewall">Histamine also takes part in the regulation of proliferation and angiogenesis and may play an important role in the growth of both normal and malignant tissue&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a> The blood supply is dependent on the formation of new blood vessels in the anastomosis&#46; <a class="elsevierStyleCrossRef" href="#bib25">25</a></p><p id="para180" class="elsevierStylePara elsevierViewall">An initial consequence of injury is the exposure of collagen in the vascular sub-endothelium&#46; Platelets attach to collagen&#44; secrete their granule constituents&#44; and form aggregates&#46;<a class="elsevierStyleCrossRef" href="#bib26">26</a> Histamine H2 receptor antagonists reduce platelet aggregation&#46;<a class="elsevierStyleCrossRef" href="#bib27">27</a></p><p id="para190" class="elsevierStylePara elsevierViewall">Histamine participates in the regulation of immune reactions&#44; in the coagulation cascade and in inflammatory responses and the formation of proinflammatory mediators&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib28">28</a> Histamine H2 receptors accelerate cell proliferation and affect the immune system&#46; H2 receptor antagonists reverse the histamine-induced increases in IL-4&#44; IL-5&#44; and interferon-&#947; levels&#46;<a class="elsevierStyleCrossRef" href="#bib8">8</a> IL-4 plays a role in wound fibroplasia&#44; and interferon-&#947; has effects on fibroblast proliferation&#44; both of which are components of wound healing&#46;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#44;<a class="elsevierStyleCrossRef" href="#bib29">29</a></p><p id="para200" class="elsevierStylePara elsevierViewall">Cimetidine&#44; an H2 receptor antagonist&#44; effectively inhibits inflammation-generated increases in nitric oxide concentrations&#46;<a class="elsevierStyleCrossRef" href="#bib28">28</a> It is known that nitric oxide plays role in phagocytosis and antimicrobial function and wound healing&#46;<a class="elsevierStyleCrossRef" href="#bib15">15</a></p><p id="para210" class="elsevierStylePara elsevierViewall">Some studies have found that pretreatment with H1 antagonists improves survival in the context of shock&#44; while H2 antagonists exacerbate mortality in low flow scenarios&#46;<a class="elsevierStyleCrossRef" href="#bib22">22</a></p><p id="para220" class="elsevierStylePara elsevierViewall">Very few studies have explored H2 blockers in the context of colorectal anastomosis&#46; Ranitidine has been shown to have no effect on experimental anastomotic strength&#44; but it did result in a lower incidence of septic complications in an animal study&#46; We cannot directly compare the results of this study to our conclusions&#44; as hydroxyproline levels were not reported and the bursting pressure was determined in a different manner&#46;<a class="elsevierStyleCrossRef" href="#bib9">9</a> In our study&#44; famotidine exerted a significant influence on anastomotic strength and decreased the collagen content of anastomoses in rats&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">In conclusion&#44; our study demonstrates that famotidine reduces the bursting pressure of colonic anastomosis and may negatively impact the collagen content of perianastomotic tissue&#46; This is likely a result of impairment of the positive influences of histamine on healing&#46; Further studies are needed to explain the mechanisms of action of famotidine in the context of anastomoses and to determine whether these findings are applicable to humans&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:6 [
        0 => array:2 [
          "identificador" => "xpalclavsec1584863"
          "titulo" => "KEYWORDS"
        ]
        1 => array:2 [
          "identificador" => "cesec10"
          "titulo" => "INTRODUCTION"
        ]
        2 => array:2 [
          "identificador" => "cesec20"
          "titulo" => "METHODS"
        ]
        3 => array:2 [
          "identificador" => "cesec30"
          "titulo" => "RESULTS"
        ]
        4 => array:2 [
          "identificador" => "cesec40"
          "titulo" => "DISCUSSION"
        ]
        5 => array:1 [
          "titulo" => "REFERENCES"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2009-01-30"
    "fechaAceptado" => "2009-03-06"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1584863"
          "palabras" => array:4 [
            0 => "Colonic anastomosis"
            1 => "Anastomotic healing"
            2 => "Famotidine"
            3 => "Histamine"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">BACKGROUND&#58;</span><p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Failure of anastomotic healing is one of the major complications in colorectal surgery&#46; Because histamine plays an important role in immune and inflammatory reactions&#44; we demonstrate the effects of famotidine on the healing of colonic anastomosis in rats&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS&#58;</span><p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Twenty-eight Sprague-Dawley rats were used in the study&#46; Excision and end-to-end anastomosis was performed in the distal colon of the rat&#46; The Famotidine Group received 2 mg&#47;kg&#47;day famotidine&#59; the Control Group received the same amount of saline&#46; Bursting pressure of anastomoses and hydroxyproline content of perianastomotic tissues were evaluated on the third and seventh days following surgery&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Bursting pressures and hydroxyproline contents for the Famotidine Group were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS&#58;</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">According to our findings&#44; famotidine exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "BACKGROUND&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "METHODS&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "RESULTS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "CONCLUSIONS&#58;"
          ]
        ]
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "tbl1"
        "etiqueta" => "Table 1 -"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Number of rats&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Bursting pressure &#40;Mean&#177;SD mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">p-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="top">3</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">131&#46;43&#177;53&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="center" valign="top">&#60;0&#46;05</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Famotidine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">79&#46;57&#177;21&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="top" style="border-bottom: 2px solid black">7</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top" style="border-bottom: 2px solid black">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">209&#46;43&#177;18&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="center" valign="top" style="border-bottom: 2px solid black">&#60;0&#46;05</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Famotidine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">188&#46;29&#177;14&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Mean bursting pressures of the Control and Famotidine Groups</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl2"
        "etiqueta" => "Table 2 -"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Number of rats&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Hydroxyproline Content &#40;Mean&#177;SD &#956;g&#47;mg tissue&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">p value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="top">3</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&#46;92&#177;0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="center" valign="top">&#60;0&#46;05</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Famotidine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&#46;34&#177;0&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="top" style="border-bottom: 2px solid black">7</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top" style="border-bottom: 2px solid black">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top" style="border-bottom: 2px solid black">4&#46;63&#177;0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="center" valign="top" style="border-bottom: 2px solid black">&#60;0&#46;05</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Famotidine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&#46;65&#177;0&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Mean hydroxyproline contents of the Control and Famotidine Groups</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:29 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early bursting strength of human colon anastomoses - an in vitro study comparing current anastomotic techniques"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              R Schwab \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S We&#223;endorf \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Gutcke \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              HP Becker \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Langenbeck&#8217;s Arch Surg"
                        "fecha" => "2002"
                        "volumen" => "386"
                        "paginaInicial" => "507"
                        "paginaFinal" => "511"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anastomotic healing in the rat colon&#58; comparison between a radiological method&#44; breaking strength and bursting pressure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              P M&#229;nsson \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              XW Zhang \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              B Jeppsson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              H Thorlacius \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00384-002-0392-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Colorectal Dis"
                        "fecha" => "2002"
                        "volumen" => "17"
                        "paginaInicial" => "420"
                        "paginaFinal" => "425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12355219"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Insulin-like growth factor I and truncated keratinocyte growth factor accelarate healing of left sided colonic anastomoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              B Egger \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              R Inglin \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J Zeeh \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              O Dirsch \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              Y Huang \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              MW B&#252;chler \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-2168.2001.01617.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Surg"
                        "fecha" => "2001"
                        "volumen" => "88"
                        "paginaInicial" => "90"
                        "paginaFinal" => "98"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11136318"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of arginine dietary supplementation on healing colonic anastomosis in the rat"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              M Shashidharan \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              KM Lin \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CA Ternent \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              TC Smyrk \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              AG Thorson \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              GJ Blatchford \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF02236217"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dis Colon Rectum"
                        "fecha" => "1999"
                        "volumen" => "42"
                        "paginaInicial" => "1613"
                        "paginaFinal" => "1617"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10613483"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modulation of growth factor and cytokine expression by nitric oxide during rat colon anastomotic healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              DT Efron \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Most \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              HP Shi \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              US Tantry \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Barbul \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s1091-255x(02)00433-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gastrointest Surg"
                        "fecha" => "2003"
                        "volumen" => "7"
                        "paginaInicial" => "393"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12654565"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              P Chithra \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              GB Sajithlal \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              G Chandrakasan \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Molec Cellular Biochem"
                        "fecha" => "1998"
                        "volumen" => "181"
                        "paginaInicial" => "71"
                        "paginaFinal" => "76"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tacrolimus enhances colon anastomotic healing in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              T Kiyama \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Tajiri \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Tokunaga \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              T Yoshiyuki \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Barbul \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1524-475x.2002.t01-1-10506.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Wound Repair Regen"
                        "fecha" => "2002"
                        "volumen" => "10"
                        "paginaInicial" => "308"
                        "paginaFinal" => "313"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12406167"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              Y Ashida \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Denda \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              T Hirao \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.2001.01238.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2001"
                        "volumen" => "116"
                        "paginaInicial" => "261"
                        "paginaFinal" => "265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11180002"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of ranitidine on healing of normal and transfusion-suppressed experimental anastomoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              SA Apostolidis \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AA Michalopoulos \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              VN Papadopoulos \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              D Paramythiotis \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Zatagias \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              P Gigigs \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Tech Coloproctol"
                        "fecha" => "2004"
                        "volumen" => "8S"
                        "paginaInicial" => "S104"
                        "paginaFinal" => "S107"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacology of acid suppression in the hospital setting&#58; focus on proton pump inhibition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              JR Pisegna \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2002"
                        "volumen" => "30S"
                        "paginaInicial" => "S356"
                        "paginaFinal" => "S361"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              IS Jamall \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              VN Finelli \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SS Que Hee \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0003-2697(81)90261-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Anal Biochem"
                        "fecha" => "1981"
                        "volumen" => "112"
                        "paginaInicial" => "70"
                        "paginaFinal" => "75"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7258630"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early postoperative enteral feeding increases anastomotic strength in a peritonitis model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              TM Khalili \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RA Navarro \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              Y Middleton \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DR Marguiles \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0002-9610(01)00818-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg"
                        "fecha" => "2001"
                        "volumen" => "182"
                        "paginaInicial" => "621"
                        "paginaFinal" => "624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11839327"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of aloe vera on the healing of dermal wounds in diabetic rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              P Chintra \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              GB Sajithlal \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              G Chandrakasan \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0378-8741(97)00124-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Ethnopharmacol"
                        "fecha" => "1998"
                        "volumen" => "59"
                        "paginaInicial" => "195"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9507904"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Healing in other tissues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              BA Mast \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0039-6109(05)70567-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Clin N Am"
                        "fecha" => "1997"
                        "volumen" => "77"
                        "paginaInicial" => "529"
                        "paginaFinal" => "547"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9194879"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "General principles of wound healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              MB Witte \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Barbul \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0039-6109(05)70566-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Clin N Am"
                        "fecha" => "1997"
                        "volumen" => "77"
                        "paginaInicial" => "509"
                        "paginaFinal" => "528"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9194878"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental study of intraperitoneal suramin on the healing of colonic anastomoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              JMH Hendriks \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              G Hubens \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              FL Wuyts \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              P Vermeulen \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Hubens \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              E Eyskens \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1365-2168.1999.01223.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Surg"
                        "fecha" => "1999"
                        "volumen" => "86"
                        "paginaInicial" => "1171"
                        "paginaFinal" => "1175"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10504372"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagen distribution and expression of matrix metalloproteinases 1 and 13 in patients with anastomotic leakage after large-bowel surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              M Stumpf \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              W Cao \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              U Klinge \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              B Klosterhalfen \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Kasperk \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              V Schumpelick \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Langenbeck&#8217;s Arch Surg"
                        "fecha" => "2002"
                        "volumen" => "386"
                        "paginaInicial" => "502"
                        "paginaFinal" => "506"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of early postoperative feeding on the healing of colonic anastomoses in the presence of intra-abdominal sepsis in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              T Kiyama \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Onda \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A Tokunaga \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              T Yoshiyuki \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Barbul \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dis Colon Rectum"
                        "fecha" => "2000"
                        "volumen" => "43S"
                        "paginaInicial" => "S54"
                        "paginaFinal" => "S58"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Healing of experimental intestinal anastomoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              T Hendricks \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              WJB Mastboom \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF02051930"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dis Colon Rectum"
                        "fecha" => "1990"
                        "volumen" => "33"
                        "paginaInicial" => "891"
                        "paginaFinal" => "901"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2209281"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of experimental diabetes and growth hormone administration on the strength of colonic anastomoses in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              M Seyer-Hansen \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              TT Andreassen \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              H Cristensen \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              H Oxlund \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Surg Res"
                        "fecha" => "1999"
                        "volumen" => "31"
                        "paginaInicial" => "418"
                        "paginaFinal" => "419"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental mast cell activation improves connective tissue repair in the perforated rat mesentery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              L Franz&#233;n \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              R Ghassemifar \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              P Malcherek \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF01986588"
                      "Revista" => array:6 [
                        "tituloSerie" => "Agents Actions"
                        "fecha" => "1991"
                        "volumen" => "33"
                        "paginaInicial" => "371"
                        "paginaFinal" => "377"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1683107"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of histamine receptor antagonists on rat mesenteric microcirculation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              HK Shahinian \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MK Ferguson \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              F Michelassi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0022-4804(87)90014-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Surg Res"
                        "fecha" => "1987"
                        "volumen" => "42"
                        "paginaInicial" => "703"
                        "paginaFinal" => "707"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2884349"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histamine&#44; histamine antagonists and regional blood flow"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              BM Johnston \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              DAA Owen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "European J Pharmacol"
                        "fecha" => "1997"
                        "volumen" => "44"
                        "paginaInicial" => "355"
                        "paginaFinal" => "363"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Healing in the gastrointestinal tract"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              FJ Thornton \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Barbul \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0039-6109(05)70568-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "Surg Clin N Am"
                        "fecha" => "1997"
                        "volumen" => "77"
                        "paginaInicial" => "549"
                        "paginaFinal" => "573"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9194880"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109715014370"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraperitoneal administration of the angiogenesis inhibitor thalidomide does not impair anastomotic healing following large bowel resection in a rabbit model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              JW Mall \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              W Schwemk \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AW Philipp \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              R B&#252;ttemeyer \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Pollmann \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00268-003-7009-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "World J Surg"
                        "fecha" => "2003"
                        "volumen" => "27"
                        "paginaInicial" => "1119"
                        "paginaFinal" => "1123"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12947492"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A role of intracellular histamine in collagen-induced platelet aggregation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              SP Saxena \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A McNichol \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              LJ Brandes \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              AB Becker \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JM Cerrard \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "1990"
                        "volumen" => "75"
                        "paginaInicial" => "407"
                        "paginaFinal" => "414"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2104768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of histamine H2 receptor antagonists on platelet aggregation in man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              MA Horton \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RJ Amos \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              RJ Jones \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0609.1983.tb02130.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Scand J Haematol"
                        "fecha" => "1993"
                        "volumen" => "31"
                        "paginaInicial" => "15"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6135250"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109709016477"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cimetidine inhibits nitric oxide associated nitrate production in a soft-tissue inflammation model in the horse"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              RP Hunter \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CR Short \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JR McClure \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CE Koch \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              ML Keowen \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JL Vansteenhouse \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Vet Pharmacol Therap"
                        "fecha" => "1999"
                        "volumen" => "22"
                        "paginaInicial" => "136"
                        "paginaFinal" => "147"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammatory mediators in wound healing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              G Henry \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              WL Garner \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0039-6109(02)00200-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Clin N Am"
                        "fecha" => "2003"
                        "volumen" => "83"
                        "paginaInicial" => "483"
                        "paginaFinal" => "507"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12822721"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/0000006400000006/v1_202212060747/S1807593222026163/v1_202212060747/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006400000006/v1_202212060747/S1807593222026163/v1_202212060747/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222026163?idApp=UINPBA00004N"
]
Article information
ISSN: 18075932
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 9 0 9
2024 October 45 42 87
2024 September 49 28 77
2024 August 37 25 62
2024 July 31 19 50
2024 June 21 14 35
2024 May 25 16 41
2024 April 18 13 31
2024 March 23 15 38
2024 February 15 12 27
2024 January 25 9 34
2023 December 23 21 44
2023 November 18 21 39
2023 October 17 18 35
2023 September 19 10 29
2023 August 13 3 16
2023 July 13 12 25
2023 June 2 8 10
2023 May 0 1 1
2023 April 2 4 6
2023 March 2 6 8
2023 February 1 1 2
2023 January 1 4 5
2022 December 9 6 15
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos