metricas
covid
Buscar en
Clinics
Toda la web
Inicio Clinics Correlation between central corneal thickness and intraocular pressure peak and ...
Journal Information

Statistics

Follow this link to access the full text of the article

Clinical Science
Correlation between central corneal thickness and intraocular pressure peak and fluctuation during the water drinking test in glaucoma patients
Rafael Lacerda Furlanetto
Corresponding author
rafael@portaeletrica.com.br

Tel.: +55 11 3067-7000
, Antonio Carlos Facio Jr, Marcelo Hatanaka, Remo Susanna Junior
Glaucoma Service, Department of Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Read
1365
Times
was read the article
329
Total PDF
1036
Total HTML
Share statistics
 array:24 [
  "pii" => "S1807593222029192"
  "issn" => "18075932"
  "doi" => "10.1590/S1807-59322010001000007"
  "estado" => "S300"
  "fechaPublicacion" => "2010-01-01"
  "aid" => "2919"
  "copyright" => "CLINICS"
  "copyrightAnyo" => "2010"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
  "subdocumento" => "fla"
  "cita" => "Clinics. 2010;65:967-70"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1807593222029209"
    "issn" => "18075932"
    "doi" => "10.1590/S1807-59322010001000008"
    "estado" => "S300"
    "fechaPublicacion" => "2010-01-01"
    "aid" => "2920"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2010;65:971-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>"
      "titulo" => "Markers of autoimmune liver diseases in postmenopausal women with osteoporosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "971"
          "paginaFinal" => "974"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Umit Secil Demirdal, Ihsan Hakk&#305; Ciftci, Vural Kavuncu"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Umit Secil"
              "apellidos" => "Demirdal"
            ]
            1 => array:2 [
              "nombre" => "Ihsan Hakk&#305;"
              "apellidos" => "Ciftci"
            ]
            2 => array:2 [
              "nombre" => "Vural"
              "apellidos" => "Kavuncu"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222029209?idApp=UINPBA00004N"
    "url" => "/18075932/0000006500000010/v1_202212010724/S1807593222029209/v1_202212010724/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1807593222029180"
    "issn" => "18075932"
    "doi" => "10.1590/S1807-59322010001000006"
    "estado" => "S300"
    "fechaPublicacion" => "2010-01-01"
    "aid" => "2918"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2010;65:961-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>"
      "titulo" => "Comparison between two shock wave regimens using frequencies of 60 and 90 impulses per minute for urinary stones"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "961"
          "paginaFinal" => "965"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Eduardo Mazzucchi, Artur H Brito, Alexandre Danilovic, Gustavo X Ebaid, Elias Chedid Neto, Jos&#233; Reinaldo Franco de Azevedo, Miguel Srougi"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Eduardo"
              "apellidos" => "Mazzucchi"
            ]
            1 => array:2 [
              "nombre" => "Artur H"
              "apellidos" => "Brito"
            ]
            2 => array:2 [
              "nombre" => "Alexandre"
              "apellidos" => "Danilovic"
            ]
            3 => array:2 [
              "nombre" => "Gustavo X"
              "apellidos" => "Ebaid"
            ]
            4 => array:2 [
              "nombre" => "Elias Chedid"
              "apellidos" => "Neto"
            ]
            5 => array:2 [
              "nombre" => "Jos&#233; Reinaldo Franco"
              "apellidos" => "de Azevedo"
            ]
            6 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Srougi"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222029180?idApp=UINPBA00004N"
    "url" => "/18075932/0000006500000010/v1_202212010724/S1807593222029180/v1_202212010724/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Clinical Science</span>"
    "titulo" => "Correlation between central corneal thickness and intraocular pressure peak and fluctuation during the water drinking test in glaucoma patients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "967"
        "paginaFinal" => "970"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Rafael Lacerda Furlanetto, Antonio Carlos Facio, Marcelo Hatanaka, Remo Susanna Junior"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Rafael Lacerda"
            "apellidos" => "Furlanetto"
            "email" => array:1 [
              0 => "rafael@portaeletrica.com.br"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "c1-cln_65p967"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Antonio Carlos"
            "apellidos" => "Facio"
            "sufijo" => "Jr"
          ]
          2 => array:2 [
            "nombre" => "Marcelo"
            "apellidos" => "Hatanaka"
          ]
          3 => array:2 [
            "nombre" => "Remo Susanna"
            "apellidos" => "Junior"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Glaucoma Service&#44; Department of Ophthalmology&#44; Faculdade de Medicina&#44; Universidade de S&#227;o Paulo&#44; S&#227;o Paulo&#44; Brazil"
            "identificador" => "af1-cln_65p967"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "c1-cln_65p967"
            "etiqueta" => "&#42;"
            "correspondencia" => "Tel&#46;&#58; &#43;55 11 3067-7000"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:6 [
        "identificador" => "fig2-cln_65p967"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 335
            "Ancho" => 415
            "Tamanyo" => 12338
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Correlation between Pachymetry and IOP fluctuation the Water Drinking Test&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Glaucoma is a progressive optic neuropathy that leads to irreversible visual impairment if not properly treated&#46; Intraocular pressure &#40;IOP&#41; is the main risk factor for glaucoma development and progression&#46; However&#44; despite IOP reduction to levels considered to be within normal limits&#44; a significant group of patients still experience progression of glaucomatous optic neuropathy&#46;<a class="elsevierStyleCrossRefs" href="#bib1">1-3</a> Recently&#44; researchers have suggested that factors such as IOP peak and diurnal IOP variability may contribute to the worsening of glaucomatous damage&#46;<a class="elsevierStyleCrossRefs" href="#bib4">4-6</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Some alternative methods to estimate the IOP profile have been described&#46; A diurnal tension curve consisting of four to five measurements during office hours is routinely used&#46; However&#44; this test may miss up to 70&#37; of IOP spikes since the highest IOP levels occur at around 6 and 8 a&#46;m&#46; in a supine position&#44; which also compromises adequate evaluation of IOP fluctuation&#46;<a class="elsevierStyleCrossRefs" href="#bib4">4&#44;7&#44;8</a> The water drinking test &#40;WDT&#41; was demonstrated to be an important tool in the management of glaucoma and has been used to assess IOP peaks <a class="elsevierStyleCrossRefs" href="#bib5">5&#44;9&#44;10</a> and the outflow system of the eye&#46;<a class="elsevierStyleCrossRef" href="#bib11">11</a></p><p id="para30" class="elsevierStylePara elsevierViewall">Central corneal thickness &#40;CCT&#41; was found to correlate positively with IOP&#44;<a class="elsevierStyleCrossRefs" href="#bib12">12&#44;13</a> whereas thinner CCT was suggested to play a role in the development and progression of glaucoma&#46;<a class="elsevierStyleCrossRefs" href="#bib14">14&#44;15</a> It was demonstrated that a diurnal range of CCT occurs&#44; but such variation may not be enough to exert a significant influence on IOP values obtained by applanation tonometry&#44; suggesting a single CCT measurement for assessment of glaucoma patients&#46;<a class="elsevierStyleCrossRef" href="#bib16">16</a></p><p id="para40" class="elsevierStylePara elsevierViewall">The aim of this study was to determine whether different corneal thicknesses may influence the IOP profile during WDT in primary open-angle glaucoma &#40;POAG&#41; subjects&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">MATERIALS AND METHODS</span><p id="para50" class="elsevierStylePara elsevierViewall">In this case series&#44; we reviewed the charts of fifty-five newly diagnosed POAG patients who were submitted&#44; between January 2008 and April 2008&#44; to the water drinking stress test and pachymetry&#46; None of the patients was taking any ocular hypotensive medication during the study&#46; Approval from the Institutional Review Board Ethics Committee was obtained for the study&#44; which followed the principles of the Declaration of Helsinki&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">Glaucoma diagnosis was based on changes in the neuroretinal rim of the optic nerve head and&#47;or retinal nerve fiber layer and the appearance of VF defects&#46;<a class="elsevierStyleCrossRef" href="#bib17">17</a> IOP values were taken into consideration&#44; but they did not constitute an element of the diagnosis&#46; At gonioscopy&#44; all enrolled eyes presented open angle and no evidence of secondary glaucoma&#44; such as pigment dispersion&#44; pseudo-exfoliation material&#44; or peripheral anterior synechiae&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">Patients submitted to any surgical procedure or laser intervention before the investigation period&#44; and patients with corneal or retinal diseases&#44; non-glaucomatous optic neuropathy&#44; or any other disease that could possibly interfere with the IOP or pachymetric measurements were excluded&#46;</p><p id="para80" class="elsevierStylePara elsevierViewall">One eye of each patient was included in this study&#46; If both eyes of the same patient were eligible&#44; one was randomly selected&#46;</p><p id="para90" class="elsevierStylePara elsevierViewall">Patients were submitted to WDT during the morning period&#46; After baseline IOP measurement&#44; they were asked to drink one liter of tap water within 5 minutes&#46; Afterwards&#44; IOP was measured three times at 15-minute intervals&#46; The maximum value of the last three measurements during this stress test was considered to be the IOP peak&#46; IOP fluctuation was considered to be the percentage of absolute fluctuation of IOP and was defined as the difference between the IOP peak and the baseline IOP divided by the baseline IOP &#40;IOP peak &#8211; baseline IOP&#47;baseline IOP&#41;&#46;</p><p id="para100" class="elsevierStylePara elsevierViewall">IOP readings were obtained with a calibrated Goldmann applanation tonometer&#44; and CCT was measured with a commercially available device &#40;AL-3000 ultrasound Biometer&#47;Pachymeter&#44; CDB Ophthalmic&#47;TOMEY&#44; Phoenix&#44; AZ&#44; USA&#41; by taking the average of 5 consecutive ultrasound pachymetry measurements in the elected eye of each subject&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">To compare pachymetry with IOP peak and IOP fluctuation&#44; patients were divided into three groups&#44; according to percentiles 33&#44;33 and 66&#44;67&#46; Thereafter&#44; we compared data from Group 1 and Group 3 and excluded the intermediate pachymetry group &#40;Group 2&#41; from analysis to verify whether there is a correlation between CCT and the WDT results&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">Statistical analysis was performed with commercial software &#40;SPSS 15&#46;0&#44; SPSS Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46; Analysis of variance and analysis of covariance were used to compare continuous data&#44; and the chi-square test was used to analyze categorical demographic data between groups&#46; The data included age&#44; gender&#44; ethnic group&#44; CCT&#44; and baseline IOP&#46; Intraocular pressure peak and IOP fluctuation during the water drinking test were evaluated in each pachymetry group using the Student&#39;s t-test&#46; Pearson&#39;s correlation was employed to verify a possible association between pachymetry values and the WDT results&#46;</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">RESULTS</span><p id="para130" class="elsevierStylePara elsevierViewall">Fifty-five eyes of 55 patients were included in this study&#46; Twenty &#40;36&#44;36&#37;&#41; patients were male&#44; and 35 &#40;63&#44;63&#37;&#41; female&#46; The mean age of all participants was 65&#44;65 &#177; 28&#44;28 years &#40;range 42&#8211;85&#41;&#46; The majority of the patients &#40;29 out of 55&#59; 52&#44;72&#37;&#41; were caucasian&#59; 10 were Afro-Americans &#40;18&#44;18&#37;&#41;&#44; 1 was of Asian descent &#40;1&#44;81&#37;&#41;&#44; and 15 were mixed &#40;27&#44;27&#37;&#41;&#46; Demographic data are summarized in <a class="elsevierStyleCrossRef" href="#t1-cln_65p967"><span class="elsevierStyleBold">Table 1</span></a>&#46;</p><elsevierMultimedia ident="t1-cln_65p967"></elsevierMultimedia><p id="para140" class="elsevierStylePara elsevierViewall">Central corneal thickness &#40;CCT&#41; measurements ranged from 477&#44;5 to 670&#44;2 &#181;m&#44; with a mean&#177;standard deviation of 544&#44;32 &#177; 36&#44;86 &#181;m&#46; The mean baseline IOP and the mean IOP peak were 23&#44;36 &#177; 6&#44;26 mmHg &#40;range 14 &#8211; 40&#41; and 30&#44;43 &#177; 8&#44;13 mmHg &#40;range 20 &#8211; 58&#41;&#44; respectively&#46; The IOP fluctuation ranged from zero to 88&#44;89&#37;&#44; where the mean IOP fluctuation was 31&#44;46 &#177; 18&#44;46&#37;&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">Mean CCT values in Groups 1 and 3 were 505&#44;81 &#177; 13&#44;86 &#181;m and 583&#44;55 &#177; 27&#44;87&#181;m&#44; respectively &#40;p&#60;0&#44;001&#41;&#46; The mean IOP peak was 31&#44;05 &#177; 9&#44;05 mmHg in Group 1 and 27&#44;83 &#177; 4&#44;92 mmHg in Group 3 &#40;p &#61; 0&#44;193&#41;&#46; The IOP fluctuation observed in Group 1 &#40;mean 28&#44;47 &#177; 16&#44;25&#37;&#41; and in Group 3 &#40;mean &#61; 33&#44;27 &#177; 21&#44;27&#37;&#41; also demonstrated no statistical significance &#40;p &#61; 0&#44;43&#41;&#46; Those results are synthesized in <a class="elsevierStyleCrossRef" href="#t2-cln_65p967"><span class="elsevierStyleBold">Table 2</span></a>&#46;</p><elsevierMultimedia ident="t2-cln_65p967"></elsevierMultimedia><p id="para160" class="elsevierStylePara elsevierViewall">No significant correlation was found between CCT and IOP peak &#40;r<span class="elsevierStyleSup">2</span> &#61; 0&#44;021&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig1-cln_65p967"><span class="elsevierStyleBold">Figure 1</span></a>&#41; or between pachymetric values and IOP fluctuation &#40;r<span class="elsevierStyleSup">2</span> &#61; 0&#44;011&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig2-cln_65p967"><span class="elsevierStyleBold">Figure 2</span></a>&#41; in the WDT&#46;</p><elsevierMultimedia ident="fig1-cln_65p967"></elsevierMultimedia><elsevierMultimedia ident="fig2-cln_65p967"></elsevierMultimedia></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">DISCUSSION</span><p id="para170" class="elsevierStylePara elsevierViewall">Glaucoma treatment is mainly based on IOP reduction&#44; but there are some cases in which&#44; even lowering IOP to what is considered adequate limits&#44; progression still occurs&#46;<a class="elsevierStyleCrossRefs" href="#bib1">1-3</a> In this study&#44; we analyzed the relationship between IOP variability&#44; which may be divided into IOP peak and IOP fluctuation&#44; and CCT&#46; Intraocular pressure peaks are not always obtained in office hours but are usually seen either in a 24-hour tension curve&#44; as shown by Drance&#44;<a class="elsevierStyleCrossRef" href="#bib7">7</a> or in the WDT&#44; as demonstrated by other authors&#46;<a class="elsevierStyleCrossRefs" href="#bib5">5&#44;18&#44;19</a> This is the reason ophthalmologists should not perform just a single IOP measurement during office hours&#46;</p><p id="para180" class="elsevierStylePara elsevierViewall">Moreover&#44; CCT was found to be another important factor associated to glaucoma progression&#44; once thinner corneas were observed to provide lower IOP readings compared to actual IOP&#44; when assessed by applanation tonometers&#46;<a class="elsevierStyleCrossRef" href="#bib15">15</a> Since Shah and coworkers showed that the diurnal variation of CCT is too small to have a significant influence on IOP measurement&#44; obtention of a single CCT measurement is likely enough for the assessment of each glaucoma patient or glaucoma suspect&#46;<a class="elsevierStyleCrossRef" href="#bib16">16</a> Based on such observation and associated to the fact that WDT is a stress test that offers a simplified method to assess the 24-hour IOP profile&#44; in our paper CCT was obtained once&#46; Further studies should evaluate the variation of CCT during the WDT&#46;</p><p id="para190" class="elsevierStylePara elsevierViewall">In this stress test&#44; the return to physiological IOP is dependent of the outflow facility&#44; so&#44; at least in part&#44; the facility of outflow determines the IOP fluctuation observed in this exam&#46; Additionally&#44; Brubaker postulated that the WDT could be used as an indirect tool to measure outflow facility&#46;<a class="elsevierStyleCrossRef" href="#bib11">11</a> Indeed&#44; the exact mechanism of the WDT over the IOP remains uncertain&#44; but recently&#44; De Moraes and colleagues demonstrated that there is an increase in choroidal thickness during WDT&#44; what could&#44; at least partially&#44; contribute to the understanding of the WDT mechanism&#46;<a class="elsevierStyleCrossRef" href="#bib20">20</a></p><p id="para200" class="elsevierStylePara elsevierViewall">This study was designed to verify any correlation between CCT and trabecular meshwork outflow facility assessed by the WDT&#46; Mosaed et al&#46; demonstrated that the IOP fluctuation had no correlation with CCT obtained during office hours&#44; what supported an independent role of CCT in glaucoma&#46;<a class="elsevierStyleCrossRef" href="#bib21">21</a> On the other hand&#44; after observing that ocular hypertensive patients with thinner corneas also had thinner nerve fiber layers&#44; Henderson suggested that there may be some anatomic association between CCT and IOP&#46;<a class="elsevierStyleCrossRef" href="#bib22">22</a> This could be a reasonable theory since the cornea and trabecular meshwork are derived from neural crest cells and&#44; though&#44; have the same embryonic origin&#46;<a class="elsevierStyleCrossRef" href="#bib23">23</a> However&#44; our findings suggest that there is no relationship between CCT and trabecular meshwork tissues&#39; resistance&#44; at least when this last parameter is evaluated through the WDT&#46;</p><p id="para210" class="elsevierStylePara elsevierViewall">Among our sample&#44; a predominance of caucasians and females was observed&#44; and our results showed a small difference of baseline IOP values between groups 1 and 3&#44; but it was not statistically significant&#46; Intending to eliminate any influence of IOP difference&#44; we also performed comparisons regarding the IOP peak and IOP fluctuation using the ANCOVA test&#46; The absence of data concerning the severity of the disease could be a limitation of our study&#44; but&#44; on the other hand&#44; we studied glaucoma patients at the moment of diagnosis&#46; Consequently&#44; all enrolled patients&#39; eyes were free of medication or drug side effects&#46; This may be an advantage because it was shown that ocular hypotensive medications may alter CCT&#46;<a class="elsevierStyleCrossRef" href="#bib24">24</a></p><p id="para220" class="elsevierStylePara elsevierViewall">Some previous papers with cultured anterior segment tissues or living animals eyes were performed to assess factors that could be related to elevated trabecular meshwork resistance&#46; <a class="elsevierStyleCrossRefs" href="#bib25">25&#44;26</a> However&#44; such models do not represent the actual dynamics of living human eyes&#46; The WDT offers clinicians a simple method to evaluate <span class="elsevierStyleItalic">in vivo</span> trabecular meshwork resistance through overcharged water ingestion&#46; In our study&#44; the WDT was used to evaluate patients with thicker and thinner corneas in order to verify one possible relationship between trabecular meshwork function and CCT&#46; We found no statistically significant evidence that a thin CCT is correlated with a different IOP peak or IOP fluctuation in the WDT than a thick CCT&#46; This information encourages us to suppose that CCT does not influence the WDT performance and may not indicate eyes that have increased resistance of the outflow drainage pathway&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">In summary&#44; the current study showed that outflow facility assessed through WDT is not influenced by CCT in untreated glaucoma patients&#46; Further studies should be conducted to investigate whether outflow facility is influenced by other corneal properties&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:6 [
        0 => array:2 [
          "identificador" => "xpalclavsec1581297"
          "titulo" => "KEYWORDS"
        ]
        1 => array:2 [
          "identificador" => "cesec10"
          "titulo" => "INTRODUCTION"
        ]
        2 => array:2 [
          "identificador" => "cesec20"
          "titulo" => "MATERIALS AND METHODS"
        ]
        3 => array:2 [
          "identificador" => "cesec30"
          "titulo" => "RESULTS"
        ]
        4 => array:2 [
          "identificador" => "cesec40"
          "titulo" => "DISCUSSION"
        ]
        5 => array:1 [
          "titulo" => "REFERENCES"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-06-16"
    "fechaAceptado" => "2010-07-12"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1581297"
          "palabras" => array:5 [
            0 => "Central Corneal Thickness"
            1 => "Intraocular Pressure"
            2 => "Primary Open-Angle Glaucoma"
            3 => "Stress Test"
            4 => "Water Drinking Test"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVE&#58;</span><p id="spara50" class="elsevierStyleSimplePara elsevierViewall">To investigate the correlation between central corneal thickness and outflow facility assessed by intraocular pressure peak and fluctuation during the water drinking test&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS&#58;</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Fifty-five newly diagnosed primary open-angle glaucoma patients submitted to central corneal thickness measurements and water drinking test were enrolled in this retrospective study&#46;&#59;&#46; Patients were divided into three groups according to their central corneal thickness&#46; Pearson&#39;s Correlation test was performed in the groups with lower and higher pachymetric values&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">The mean age was 65&#44;65 &#177; 28&#44;28 years&#59; 63&#44;63&#37; were female and 52&#44;72&#37; were caucasian&#46; The mean central corneal thickness was 544&#44;32 &#177; 36&#44;86 &#181;m&#44; and the mean baseline intraocular pressure was 23&#44;36 &#177; 6&#44;26 mmHg&#46; During the water drinking test&#44; the mean intraocular pressure peak and mean intraocular pressure fluctuation were 30&#44;43 &#177; 8&#44;13 mmHg and 31&#44;46 &#177; 18&#44;46&#37;&#44; respectively&#46; No relevant correlation was detected between the central corneal thickness and the intraocular pressure peak &#40;r<span class="elsevierStyleSup">2</span> &#61; 0&#44;021&#41; or between the central corneal thickness and the intraocular pressure fluctuation &#40;r<span class="elsevierStyleSup">2</span> &#61; 0&#44;011&#41;&#46; Group 1 presented a mean central corneal thickness of 505&#44;81 &#177; 13&#44;86 &#181;m&#44; and Group 3 was 583&#44;55 &#177; 27&#44;87 &#181;m &#40;p &#61; 0&#44;001&#41;&#46; The mean intraocular pressure peak was 31&#44;05 &#177; 9&#44;05 mmHg and 27&#44;83 &#177; 4&#44;92 mmHg in Group 1 and in Group 3&#44; respectively &#40;p &#61; 0&#44;193&#41;&#46; The difference of intraocular pressure fluctuation was not statistically significant between Group 1 &#40;mean 28&#44;47 &#177; 16&#44;25&#37;&#41; and Group 3 &#40;mean 33&#44;27 &#177; 21&#44;27&#37;&#41; &#40;p &#61; 0&#44;43&#41;&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSION&#58;</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">In our case series&#44; no correlation was found between central corneal thickness and water drinking test results&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "OBJECTIVE&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "METHODS&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "RESULTS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "CONCLUSION&#58;"
          ]
        ]
      ]
    ]
    "multimedia" => array:4 [
      0 => array:6 [
        "identificador" => "fig1-cln_65p967"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 332
            "Ancho" => 415
            "Tamanyo" => 13878
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Correlation between Pachymetry and IOP peak in the Water Drinking Test&#46;</p>"
        ]
      ]
      1 => array:6 [
        "identificador" => "fig2-cln_65p967"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 335
            "Ancho" => 415
            "Tamanyo" => 12338
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Correlation between Pachymetry and IOP fluctuation the Water Drinking Test&#46;</p>"
        ]
      ]
      2 => array:6 [
        "identificador" => "t1-cln_65p967"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="bottom" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Group 1 &#40;477&#8211;523&#44;19&#181;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Group 3 &#40;559&#44;43&#8211;671&#181;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">P Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleItalic">Number of Eyes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#44;000 <a class="elsevierStyleCrossRef" href="#tfn1-cln_65p967">&#8727;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Mean Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">65&#44;50&#177;12&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">66&#44;11&#177;7&#44;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#44;870 <a class="elsevierStyleCrossRef" href="#tfn1-cln_65p967">&#8727;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Age Range &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">43 &#8211; 85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">44 &#8211; 76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Gender &#40;M&#47;F&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">7&#47;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">6&#47;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#44;248 &#8224;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleItalic">Ethnicity</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#44;115 &#8224;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Caucasians&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Afro-Americans&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Asians&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom"><span class="elsevierStyleHsp" style=""></span>Mixed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tfn1-cln_65p967"
              "etiqueta" => "&#8727;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara10"><span class="elsevierStyleItalic">t</span> test &#8224;&#8201;Chi Square test SD &#61; Standard Deviation</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Demographic data according to Central Corneal Thickness</p>"
        ]
      ]
      3 => array:6 [
        "identificador" => "t2-cln_65p967"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Group 1 &#40;477&#8211;523&#44;19&#181;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="bottom" scope="col" style="border-bottom: 2px solid black">Group 3 &#40;559&#44;43&#8211;671&#181;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col" style="border-bottom: 2px solid black">P Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Mean CCT &#40;&#181;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">505&#44;81 &#177; 13&#44;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">583&#44;55 &#177; 27&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#60;0&#44;001 <a class="elsevierStyleCrossRef" href="#tfn2-cln_65p967">&#8727;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">Baseline IOP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">24&#44;67 &#177; 8&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">21&#44;11 &#177; 3&#44;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#44;073 <a class="elsevierStyleCrossRef" href="#tfn2-cln_65p967">&#8727;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">IOP Peak &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">31&#44;05 &#177; 9&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">27&#44;83 &#177; 4&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#44;866 &#8224;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="bottom">IOP Fluctuation &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">28&#44;47 &#177; 16&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">33&#44;27 &#177; 21&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#44;913 &#8224;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tfn2-cln_65p967"
              "etiqueta" => "&#8727;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara20"><span class="elsevierStyleItalic">t</span> test <span class="elsevierStyleBold">&#8224;</span>&#8201;ANCOVA IOP &#61; Intraocular Pressure&#59; CCT &#61; Central Corneal Thickness</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Results of Pachymetry and IOP measurements in Water Drinking Test</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:26 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between control of intraocular pressure and visual field deterioration&#46; The AGIS Investigators"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              The Advanced Glaucoma Intervention Study &#40;AGIS&#41;&#58; 7 \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0002-9394(00)00538-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "2000"
                        "volumen" => "130"
                        "paginaInicial" => "429"
                        "paginaFinal" => "440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11024415"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collaborative Normal-Tension Glaucoma Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0002-9394(98)00272-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "1998"
                        "volumen" => "126"
                        "paginaInicial" => "498"
                        "paginaFinal" => "505"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9780094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between intraocular pressure and visual field progression in glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              BC Chauhan \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SM Drance \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/BF00181772"
                      "Revista" => array:6 [
                        "tituloSerie" => "Graefes Arch Clin Exp Ophthalmol"
                        "fecha" => "1992"
                        "volumen" => "230"
                        "paginaInicial" => "521"
                        "paginaFinal" => "526"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1427134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/BF00181772"
                      "WWW" => array:1 [
                        "link" => "10&#46;1007&#47;BF00181772"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circadian variations in intraocular pressure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              R Zeimer \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "editores" => "RRitch, M BShields, TKrupin"
                        "titulo" => "The glaucomas"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relation between intraocular pressure peak in the water drinking test and visual field progression in glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              R Susanna Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RM Vessani \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              L Sakata \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              LC Zacarias \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              M Hatanaka \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bjo.2005.070649"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Ophthalmol"
                        "fecha" => "2005"
                        "volumen" => "89"
                        "paginaInicial" => "1298"
                        "paginaFinal" => "1301"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16170120"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              S Asrani \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              R Zeimer \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J Wilensky \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              D Gieser \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              S Vitale \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              K Lindenmuth \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Glaucoma"
                        "fecha" => "2000"
                        "volumen" => "9"
                        "paginaInicial" => "134"
                        "paginaFinal" => "142"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The significance of the diurnal tension variations in normal and glaucomatous eyes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              SM Drance \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Ophthalmol"
                        "fecha" => "1960"
                        "volumen" => "64"
                        "paginaInicial" => "494"
                        "paginaFinal" => "501"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              JH Liu \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              X Zhang \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              DF Kripke \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RN Weinreb \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1167/iovs.02-0666"
                      "Revista" => array:6 [
                        "tituloSerie" => "Invest Ophthalmol Vis Sci"
                        "fecha" => "2003"
                        "volumen" => "44"
                        "paginaInicial" => "1586"
                        "paginaFinal" => "1590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12657596"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1167/iovs.02-0666"
                      "WWW" => array:1 [
                        "link" => "10&#46;1167&#47;iovs&#46;02-0666"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation of asymmetric glaucomatous visual field damage and water-drinking test response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              R Susanna Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Hatanaka \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              RM Vessani \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Pinheiro \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Morita \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1167/iovs.04-0268"
                      "Revista" => array:6 [
                        "tituloSerie" => "Invest Ophthalmol Vis Sci"
                        "fecha" => "2006"
                        "volumen" => "47"
                        "paginaInicial" => "641"
                        "paginaFinal" => "644"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16431962"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1167/iovs.04-0268"
                      "WWW" => array:1 [
                        "link" => "10&#46;1167&#47;iovs&#46;04-0268"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does peak intraocular pressure measured by water drinking test reflect peak circadian levels&#63; A pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              RS Kumar \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MH de Guzman \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              PY Ong \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              I Goldberg \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1442-9071.2008.01765.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Experiment Ophthalmol"
                        "fecha" => "2008"
                        "volumen" => "36"
                        "paginaInicial" => "312"
                        "paginaFinal" => "315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18700916"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1111/j.1442-9071.2008.01765.x"
                      "WWW" => array:1 [
                        "link" => "10&#46;1111&#47;j&#46;1442-9071&#46;2008&#46;01866&#46;x"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Importance of outflow facility"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              RF Brubaker \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Int Glaucoma Rev"
                        "fecha" => "2001"
                        "volumen" => "3"
                        "paginaInicial" => "5"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Applanation tonometry and central corneal thickness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              N Ehlers \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Bramsen \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S Sperling \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Ophthalmol Scand"
                        "fecha" => "1975"
                        "volumen" => "53"
                        "paginaInicial" => "34"
                        "paginaFinal" => "43"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of corneal thickness on applanation tonometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              MM Whitacre \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RA Stein \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              K Hassanein \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0002-9394(14)71455-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "1993"
                        "volumen" => "115"
                        "paginaInicial" => "592"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8488910"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The ccular hypertension treatment study&#58; Baseline factors that predict the onset of primary open-angle glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              MO Gordon \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JA Beiser \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JD Brandt \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DK Heuer \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              EJ Higginbotham \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              CA Johnson \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Ophthalmol"
                        "fecha" => "2002"
                        "volumen" => "120"
                        "paginaInicial" => "714"
                        "paginaFinal" => "720"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Corneal thickness as a risk factor for visual field loss in patients with preperimetric glaucomatous optic neuropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              FA Medeiros \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PA Sample \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              LM Zangwill \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Bowd \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              M Aihara \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RN Weinreb \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0002-9394(03)00484-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "2003"
                        "volumen" => "136"
                        "paginaInicial" => "805"
                        "paginaFinal" => "813"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14597030"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of diurnal variation in central corneal thickness and intraocular pressure for patients with suspected glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              S Shah \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Spedding \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Bhojwani \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Kwartz \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              D Henson \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              D McLeod \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0161-6420(00)00090-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthalmology"
                        "fecha" => "2000"
                        "volumen" => "107"
                        "paginaInicial" => "1191"
                        "paginaFinal" => "1193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10857842"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/s0161-6420(00)00090-7"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;S0161-6420&#40;00&#41;00090-7"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary open-angle glaucoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              RN Weinreb \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PT Khaw \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(04)16257-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2004"
                        "volumen" => "363"
                        "paginaInicial" => "1711"
                        "paginaFinal" => "1720"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15158634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/S0140-6736(04)16257-0"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;S0140-6736&#40;04&#41;16257-0"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normal tension glaucoma&#58; The value of predictive tests"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              K Yoshikawa \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Inohue \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              Y Inohue \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Ophthalmol"
                        "fecha" => "1993"
                        "volumen" => "71"
                        "paginaInicial" => "463"
                        "paginaFinal" => "470"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biostatistical analysis of the Collaborative Glaucoma Study&#46; I&#46; Summary report of the risk factors for glaucomatous visual-field defects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              MF Armaly \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              DE Krueger \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              L Maunder \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              B Becker \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              J Hetherington Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AE Kolker \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Ophthalmol"
                        "fecha" => "1980"
                        "volumen" => "98"
                        "paginaInicial" => "2163"
                        "paginaFinal" => "2171"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Choroidal expansion during the water drinking test"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              CG De Moraes \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AS Reis \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AF Cavalcante \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              ME Sano \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Susanna Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s00417-008-0969-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Graefes Arch Clin Exp Ophthalmol"
                        "fecha" => "2009"
                        "volumen" => "247"
                        "paginaInicial" => "385"
                        "paginaFinal" => "389"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18987872"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/s00417-008-0969-2"
                      "WWW" => array:1 [
                        "link" => "10&#46;1007&#47;s00417-008-0969-2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of central corneal thickness and 24-hour intraocular pressure fluctuation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              S Mosaed \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              WD Chamberlain \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JH Liu \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              FA Medeiros \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              RN Weinreb \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/IJG.0b013e31814b9922"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Glaucoma"
                        "fecha" => "2008"
                        "volumen" => "17"
                        "paginaInicial" => "85"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18344752"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertensive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              PA Henderson \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              FA Medeiros \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              LM Zangwill \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RN Weinreb \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ophtha.2004.09.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthalmology"
                        "fecha" => "2005"
                        "volumen" => "112"
                        "paginaInicial" => "251"
                        "paginaFinal" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15691559"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.ophtha.2004.09.016"
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;j&#46;ophtha&#46;2004&#46;09&#46;016"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The eye&#58; Basic sciences in practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              JV Forrester \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AD Dick \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              PG McMenamin \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              WR Lee \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2002"
                        "editorial" => "Saunders Ltd"
                        "editorialLocalizacion" => "Aberdeen"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of prostaglandin analogs and prostamide on central corneal thickness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              M Hatanaka \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RM Vessani \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              IR Elias \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Morita \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Susanna Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1089/jop.2007.0125"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Ocul Pharmacol Ther"
                        "fecha" => "2009"
                        "volumen" => "25"
                        "paginaInicial" => "51"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19232014"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1089/jop.2007.0125"
                      "WWW" => array:1 [
                        "link" => "10&#46;1089&#47;jop&#46;2007&#46;0125"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of cyclic intraocular pressure on conventional outflow facility"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              RF Ramos \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              WD Stamer \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1167/iovs.07-0863"
                      "Revista" => array:6 [
                        "tituloSerie" => "Invest Ophthalmol Vis Sci"
                        "fecha" => "2008"
                        "volumen" => "49"
                        "paginaInicial" => "275"
                        "paginaFinal" => "281"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18172103"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1167/iovs.07-0863"
                      "WWW" => array:1 [
                        "link" => "10&#46;1167&#47;iovs&#46;07-0863"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors affecting outflow facility calculations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              B Tian \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              Y Hu \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              BT Gabelt \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              PL Kaufman \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Exp Eye Res"
                        "fecha" => "2006"
                        "volumen" => "83"
                        "paginaInicial" => "1515"
                        "paginaFinal" => "1520"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "10&#46;1016&#47;j&#46;exer&#46;2006&#46;08&#46;008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/0000006500000010/v1_202212010724/S1807593222029192/v1_202212010724/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006500000010/v1_202212010724/S1807593222029192/v1_202212010724/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222029192?idApp=UINPBA00004N"
]
Article information
ISSN: 18075932
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 3 2 5
2024 October 46 35 81
2024 September 48 20 68
2024 August 72 35 107
2024 July 79 32 111
2024 June 51 20 71
2024 May 61 13 74
2024 April 94 15 109
2024 March 91 14 105
2024 February 70 12 82
2024 January 35 10 45
2023 December 63 24 87
2023 November 67 16 83
2023 October 60 25 85
2023 September 29 19 48
2023 August 18 11 29
2023 July 11 14 25
2023 June 16 1 17
2023 May 31 2 33
2023 April 37 1 38
2023 March 22 2 24
2023 February 12 3 15
2023 January 6 3 9
2022 December 14 0 14
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos