ORIGINAL RESEARCH
MITRAL VALVE ANNULOPLASTY WITH A BOVINE PERICARDIAL STRIP - 18-YEAR RESULTS
Pablo Maria Alberto Pomerantzeff, Carlos Manuel de Almeida Brandão, João Marcelo Ancilon Albuquerque, Paola Yastrevov Pomerantzeff, Flavio Takeda, Sergio A. Oliveira
Heart Institute (INCOR), Hospital das Clínicas, Faculty of Medicine, University of São Paulo – São Paulo/SP, Brazil
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Oliveira" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Pablo Maria Alberto" "apellidos" => "Pomerantzeff" "email" => array:1 [ 0 => "dcipablo@incor.usp.br" ] ] 1 => array:2 [ "nombre" => "Carlos Manuel" "apellidos" => "de Almeida Brandão" ] 2 => array:2 [ "nombre" => "João Marcelo Ancilon" "apellidos" => "Albuquerque" ] 3 => array:2 [ "nombre" => "Paola Yastrevov" "apellidos" => "Pomerantzeff" ] 4 => array:2 [ "nombre" => "Flavio" "apellidos" => "Takeda" ] 5 => array:2 [ "nombre" => "Sergio A." "apellidos" => "Oliveira" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Heart Institute (INCOR), Hospital das Clínicas, Faculty of Medicine, University of São Paulo – São Paulo/SP, Brazil" "identificador" => "aff1" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig4" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 748 "Ancho" => 1484 "Tamanyo" => 65098 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Actuarial freedom from thromboembolism (% +/- Standard Error)</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para10" class="elsevierStylePara elsevierViewall">Mitral valve repair (MVR) has been established as an excellent procedure for treating mitral regurgitation.<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a> A number of studies have shown the importance of preserving the anatomic characteristics of the mitral annulus.<span class="elsevierStyleInf">2</span> Posterior annuloplasty of the mitral valve can be performed with rigid or flexible materials, and both techniques appear to produce better results than mitral valve replacement.<a class="elsevierStyleCrossRefs" href="#bib3"><span class="elsevierStyleSup">3–6</span></a> The purpose of this study was to analyze the late results of posterior annuloplasty using a bovine pericardial strip.</p><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">MATERIALS AND METHODS</span><p id="para20" class="elsevierStylePara elsevierViewall">Between January 1984 and December 2002, 273 consecutive patients with mitral regurgitation underwent mitral valve repair with posterior annuloplasty using a bovine pericardial strip (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). We excluded patients who had undergone other procedures in the posterior annulus. All procedures were approved by the Scientific Committee of the Heart Institute of University of São Paulo Medical School, and informed consent was obtained from each patient.</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para30" class="elsevierStylePara elsevierViewall">The patients ranged in age between 1 and 76 years, with an average age of 38.3 years and a standard deviation of 21.1 years. One hundred and forty four (52.7%) patients were women and 129 (47.3%) were men. According to the New York Heart Association (NYHA) classification, 25 (9.3%) patients were in functional class II; 138 (50.4%) in class III, and 110 (40.3%) in class IV. Rheumatic fever was present in 142 (52.0%) patients. The other causes of mitral valve disease were ischemia in 34 (12.4%), degenerative disease in 23 (8.5%), congenital malformations in 17 (6.2%), cardiomyopathy in 11 (3.9%), endocarditis in 8 (3.1%), unknown in 15 (5.4%), and other in 23 (8.5%).</p><p id="para40" class="elsevierStylePara elsevierViewall">Associated techniques of valve repair were employed in 71 patients (26.0%). Chordal shortening was employed in 25 (9.2%) patients, papillary muscle splitting in 15 (5.5%), anterior leaflet resection in 11 (4.0%), chordal resection in 6 (2.2%), decalcification in 4 (1.5%), cleft suture in 4 (1.5%), papillary shortening in 2 (0.7%), leaflet thinning in 2 (0.7%), chordal transposition in 1 (0.3%), and anterior leaflet plication in 1 (0.3%).</p><p id="para50" class="elsevierStylePara elsevierViewall">Associated procedures were performed in 137 (50.2%) patients. Aortic valve replacement was performed in 57 (20.9%) patients, tricuspid annuloplasty in 36 (13.2%) patients, coronary artery bypass graft in 29 (10.6%) patients, aortic valve repair in 6 (2.2%), aortic valve commissurotomy in 5 (1.8%), atrial septal defect closure in 3 (1.1%), and left ventricular myectomy in 1 (0.3%).</p><p id="para60" class="elsevierStylePara elsevierViewall">Postoperative follow-up was obtained by contact with the patients through scheduled hospital visits, telephone calls, or questionnaires sent by mail. Data are presented according to the revised rules for data and nomenclature presentation.<a class="elsevierStyleCrossRef" href="#bib7"><span class="elsevierStyleSup">7</span></a></p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">RESULTS</span><p id="para70" class="elsevierStylePara elsevierViewall">The hospital mortality was 3.3% (9 patients), and the main cause was low cardiac output (6 patients). Two of these patients were children undergoing surgery for active rheumatic carditis. The other 3 patients presented multiple organ failure.</p><p id="para80" class="elsevierStylePara elsevierViewall">One patient presented persistent mitral regurgitation and underwent valve replacement on the 27<span class="elsevierStyleSup">nd</span> day of the postoperative period. One patient presented endocarditis and was treated clinically with good evolution.</p><p id="para90" class="elsevierStylePara elsevierViewall">During the late postoperative period, 8 (3.0%) patients died. The causes of late mortality were congestive heart failure (3), stroke (2), unknown (2), and myocardial infarction (1). Linearized rates of late events are presented in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>.</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para100" class="elsevierStylePara elsevierViewall">Actuarial survival was 55.1% ± 16.8% (mean ± SD) in 18 years (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>). Freedom from reoperation was 59.1% ± 13.9% (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>), freedom from thromboembolism was 97.4% ± 2.3% (<a class="elsevierStyleCrossRef" href="#fig4">Figure 4</a>), freedom from hemolysis was 99.2% ± 0.2% (<a class="elsevierStyleCrossRef" href="#fig5">Figure 5</a>) and freedom from endocarditis was 99.6% ± 1.0% in 18 years (<a class="elsevierStyleCrossRef" href="#fig6">Figure 6</a>).</p><elsevierMultimedia ident="fig2"></elsevierMultimedia><elsevierMultimedia ident="fig3"></elsevierMultimedia><elsevierMultimedia ident="fig4"></elsevierMultimedia><elsevierMultimedia ident="fig5"></elsevierMultimedia><elsevierMultimedia ident="fig6"></elsevierMultimedia><p id="para110" class="elsevierStylePara elsevierViewall">Follow-up was 85.1% complete (5993 months/ patients). In the late follow-up period, 215 patients (83.9%) were in NYHA functional class I, 22 (8.6%) were in class II, 18 (7.1%) were in class III, and 1 (0.4%) was in class IV.</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">DISCUSSION</span><p id="para120" class="elsevierStylePara elsevierViewall">In Brazil, valve procedures represent at least 30% of cardiac operations, and the primary cause of valve disease is rheumatic fever.<a class="elsevierStyleCrossRef" href="#bib8"><span class="elsevierStyleSup">8</span></a> In this series, rheumatic fever was present in 52% of the patients. According to David<a class="elsevierStyleCrossRef" href="#bib9"><span class="elsevierStyleSup">9</span></a> and Antunes,<a class="elsevierStyleCrossRef" href="#bib10"><span class="elsevierStyleSup">10</span></a> mitral valve repair in rheumatic patients is a better operation than mitral valve replacement when repair is feasible, because it results in lower immediate and late mortality rates and lower risk of valve-related events. In a previously published series, late results with mitral valve repair in rheumatic patients were satisfactory, especially in patients older than 16 years, who presented lower rates of reoperation in late evolution.<a class="elsevierStyleCrossRef" href="#bib11"><span class="elsevierStyleSup">11</span></a></p><p id="para130" class="elsevierStylePara elsevierViewall">Our hospital mortality was low; at 9 patients, 2 of which had undergone surgery for active rheumatic carditis, which is associated with higher morbidity and mortality.<a class="elsevierStyleCrossRef" href="#bib12"><span class="elsevierStyleSup">12</span></a> Long-term survival has been satisfactory, similar to that reported with flexible ring annuloplasty.<a class="elsevierStyleCrossRef" href="#bib13"><span class="elsevierStyleSup">13</span></a></p><p id="para140" class="elsevierStylePara elsevierViewall">The use of flexible materials to perform valve annuloplasty in mitral regurgitation is intended to preserve the anatomical and physiological characteristics of the mitral annulus,<a class="elsevierStyleCrossRefs" href="#bib14"><span class="elsevierStyleSup">14,15</span></a> since we know that the use of prosthetic rings, especially the rigid ones, impedes normal contraction of the annulus.<a class="elsevierStyleCrossRef" href="#bib16"><span class="elsevierStyleSup">16</span></a> The clinical and echocardiographic results with flexible mitral annuloplasty are well established in the literature.<a class="elsevierStyleCrossRefs" href="#bib6"><span class="elsevierStyleSup">6,17</span></a></p><p id="para150" class="elsevierStylePara elsevierViewall">Our late results were comparable with other reported series, with low rates of late events as presented by Duran et al.<a class="elsevierStyleCrossRef" href="#bib18"><span class="elsevierStyleSup">18</span></a> and Skoularigis.<a class="elsevierStyleCrossRef" href="#bib19"><span class="elsevierStyleSup">19</span></a> Freedom from reoperation of 59.1% in 18 years is reasonable, considering the prevalence of rheumatic disease in these patients. We should also emphasize the great number of associated procedures of valve repair<a class="elsevierStyleCrossRef" href="#bib20"><span class="elsevierStyleSup">20</span></a> and associated operations<a class="elsevierStyleCrossRef" href="#bib21"><span class="elsevierStyleSup">21</span></a> employed in this series that were identified in the literature as risk factors for reoperation in the late postoperative period.</p><p id="para160" class="elsevierStylePara elsevierViewall">The use of associated techniques with valve repair, such as chordal shortening, anterior leaflet resection, and papillary muscle splitting must be accompanied by careful intraoperative decision-making and should be performed by an expert surgeon.<a class="elsevierStyleCrossRefs" href="#bib9"><span class="elsevierStyleSup">9,22</span></a> In rheumatic patients, we repair valves when we judge that the repair will restore satisfactory function to the valve, especially when the anterior leaflet is pliable. In rupture of anterior leaflet chordae, triangular resection associated with posterior annuloplasty is feasible and simple, as demonstrated by others.<a class="elsevierStyleCrossRefs" href="#bib23"><span class="elsevierStyleSup">23,24</span></a></p><p id="para170" class="elsevierStylePara elsevierViewall">Similar to our own findings, reported rates of thromboembolism or endocarditis after mitral valve repair have been low. According to Perier et al.,<a class="elsevierStyleCrossRef" href="#bib25"><span class="elsevierStyleSup">25</span></a> most of the thromboembolic events occur during the immediate postoperative period, as shown in our series.</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">CONCLUSION</span><p id="para180" class="elsevierStylePara elsevierViewall">The use of a bovine pericardial strip for posterior annuloplasty presents some advantages on the annuloplasty rings, even the flexible ones, such as the low cost, the disposability of the material in hospitals, and the ease of handling the bovine pericardium tissue. The technique allows correction of the annulus and prevents further annular dilatation.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1585266" "titulo" => "KEYWORDS" ] 1 => array:3 [ "identificador" => "xres1815613" "titulo" => "RESUMO" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs60" "titulo" => "OBJETIVO" ] 1 => array:2 [ "identificador" => "ceabs70" "titulo" => "MÉTODOS" ] 2 => array:2 [ "identificador" => "ceabs80" "titulo" => "RESULTADOS" ] 3 => array:2 [ "identificador" => "ceabs90" "titulo" => "CONCLUSÕES" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1585267" "titulo" => "UNITERMOS" ] 3 => array:2 [ "identificador" => "cesec10" "titulo" => "MATERIALS AND METHODS" ] 4 => array:2 [ "identificador" => "cesec20" "titulo" => "RESULTS" ] 5 => array:2 [ "identificador" => "cesec30" "titulo" => "DISCUSSION" ] 6 => array:2 [ "identificador" => "cesec40" "titulo" => "CONCLUSION" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-02-25" "fechaAceptado" => "2005-05-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1585266" "palabras" => array:5 [ 0 => "Mitral valve" 1 => "Annuloplasty" 2 => "Valve surgery" 3 => "Bovine pericardium" 4 => "Valve repair" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "UNITERMOS" "identificador" => "xpalclavsec1585267" "palabras" => array:5 [ 0 => "Valva mitral" 1 => "Anuloplastia" 2 => "Cirurgia valvar" 3 => "Pericardio bovino" 4 => "Plástica valvar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">PURPOSE</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">Prosthetic annuloplasty rings are currently used in mitral reconstruction. Posterior annuloplasty with a bovine pericardial strip is a technique largely used in the Heart Institute of University of São Paulo Medical School. The purpose of the study was to analyze the late results of mitral valve repair with posterior annuloplasty using a bovine pericardial strip.</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">Between January 1984 and December 2002, 273 patients underwent mitral valve repair with posterior pericardial annuloplasty in the Heart Institute of University of São Paulo Medical School. One hundred and forty four (52.7%) were women and ages ranged between 1 and 76 years (38.3 ± 21.1). Rheumatic fever was present in 52.0% of the patients. Associated techniques were employed in 26.0% of the patients, and the most frequent was chordal shortening (9.2%).</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">Hospital mortality was 3.3% (9 patients), with the major cause being low cardiac output (6 patients). Actuarial survival was 55.1% ± 16.8% in 18 years. During the 18-year follow-up: patients were free from the following: reoperation (59.1% ±± 13.9%, (percent +/- Standard Error), thromboembolism (97.4% ± 2.3%), hemolysis (99.2% ± 0.2%), and endocarditis (99.6% ± 1.0%). In the late follow-up period, 83.9% were classified as New York Heart Association functional class I.</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS</span><p id="spara110" class="elsevierStyleSimplePara elsevierViewall">Late results with mitral valve repair with posterior annuloplasty using a bovine pericardial strip were satisfactory. The technique is feasible, reproducible, and cost effective.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "PURPOSE" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHODS" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSIONS" ] ] ] "pt" => array:3 [ "titulo" => "RESUMO" "resumen" => "<span id="ceabs60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">OBJETIVO</span><p id="spara130" class="elsevierStyleSimplePara elsevierViewall">Anéis protéticos para anuloplastia são usados nas plásticas da valva mitral de forma rotineira. A anuloplastia posterior com tira de pericárdio bovino é uma técnica largamente utilizada no Instituto do Coração – HC – FMUSP. O objetivo deste estudo foi analisar os resultados tardios da plástica da valva mitral com a utilização desta técnica na nossa instituição.</p></span> <span id="ceabs70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">MÉTODOS</span><p id="spara140" class="elsevierStyleSimplePara elsevierViewall">Entre janeiro de 1984 e dezembro de 2002, 273 pacientes foram submetidos a plástica da valva mitral com anuloplastia posterior no Instituto do Coração. Foram excluídos os pacientes submetidos a outros procedimentos no anel posterior. Cento e quarenta e quatro (52,7%) eram do sexo feminino e a idade variou entre 1 e 76 anos (média: 38,3 ± 21,1 anos). Em 52% dos pacientes, havia história de febre reumática. Técnicas associadas para reconstrução valvar foram empregadas em 26% dos casos, sendo a mais utilizada, o encurtamento de cordas (9,2%).</p></span> <span id="ceabs80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">RESULTADOS</span><p id="spara150" class="elsevierStyleSimplePara elsevierViewall">A mortalidade hospitalar foi de 3,3% (9 casos). A principal causa de óbito foi baixo débito cardíaco (6 pacientes). A sobrevida actuarial foi de 55,1 ± 16,8% (percent +/- Standard Error) em 18 anos, sobrevida livre de reoperação, tromboembolismo, hemólise e endocardite foram respectivamente de 59,1 ± 13,9%, 97,4 ± 2,3%, 99,2 ± 0,2%, 99,6 ± 1,0% em 18 anos. No seguimento tardio, 83,9% dos pacientes se encontravam em classe funcional I (NYHA).</p></span> <span id="ceabs90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">CONCLUSÕES</span><p id="spara160" class="elsevierStyleSimplePara elsevierViewall">Concluímos que os resultados tardios foram satisfatórios. A técnica é fácil, reprodutível e de baixo custo.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs60" "titulo" => "OBJETIVO" ] 1 => array:2 [ "identificador" => "ceabs70" "titulo" => "MÉTODOS" ] 2 => array:2 [ "identificador" => "ceabs80" "titulo" => "RESULTADOS" ] 3 => array:2 [ "identificador" => "ceabs90" "titulo" => "CONCLUSÕES" ] ] ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 535 "Ancho" => 1717 "Tamanyo" => 162026 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Technique of posterior annuloplasty with bovine pericardial strip</p>" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 644 "Ancho" => 1600 "Tamanyo" => 57743 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Actuarial survival (% +/- Standard Error)</p>" ] ] 2 => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 657 "Ancho" => 1683 "Tamanyo" => 57295 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Actuarial freedom from reoperation (% +/- Standard Error)</p>" ] ] 3 => array:7 [ "identificador" => "fig4" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 748 "Ancho" => 1484 "Tamanyo" => 65098 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Actuarial freedom from thromboembolism (% +/- Standard Error)</p>" ] ] 4 => array:7 [ "identificador" => "fig5" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 741 "Ancho" => 1455 "Tamanyo" => 66032 ] ] "descripcion" => array:1 [ "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Actuarial freedom from hemolysis (% +/- Standard Error)</p>" ] ] 5 => array:7 [ "identificador" => "fig6" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 732 "Ancho" => 1478 "Tamanyo" => 52060 ] ] "descripcion" => array:1 [ "en" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Actuarial freedom from endocarditis (% +/- Standard Error)</p>" ] ] 6 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">EVENTS \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">PATIENTS \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">LINEARIZED RATES (% patient-year) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Endocarditis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Thromboembolism \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hemolysis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reoperation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Linearized rates of late events</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac valve surgery - the “French correction”" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ A Carpentier \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "1983" "volumen" => "86" "paginaInicial" => "323" "paginaFinal" => "327" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6887954" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The movements of the annulus of the mitral valve" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ PKB Davis \n 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array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8526596" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mitral valve remodeling: long-term results with posterior pericardial annuloplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ R Scrofani \n \t\t\t\t\t\t\t\t """ 1 => """ S Moriggia \n \t\t\t\t\t\t\t\t """ 2 => """ M Salati \n \t\t\t\t\t\t\t\t """ 3 => """ P Fundaro \n \t\t\t\t\t\t\t\t """ 4 => """ P Danna \n \t\t\t\t\t\t\t\t """ 5 => """ C Santoli \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0003-4975(95)01139-0" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "1996" "volumen" => "61" "paginaInicial" => "895" "paginaFinal" => "899" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8619713" "web" => 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Comparative study between valve reconstruction and replacement for rheumatic mitral valve disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ MJ Antunes \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "1990" "volumen" => "99" "paginaInicial" => "990" "paginaFinal" => "1001" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mitral valve repair in rheumatic patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ PM Pomerantzeff \n \t\t\t\t\t\t\t\t """ 1 => """ CM Brandao \n \t\t\t\t\t\t\t\t """ 2 => """ CM Faber \n \t\t\t\t\t\t\t\t """ 3 => """ M Grinberg \n \t\t\t\t\t\t\t\t """ 4 => """ LF Cardoso \n \t\t\t\t\t\t\t\t """ 5 => """ F Tarasoutchi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Heart Surg Forum" "fecha" => "2000" "volumen" => "3" "numero" => "4" "paginaInicial" => "273" "paginaFinal" => "276" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11178286" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical treatment of acute episodes of rheumatic fever" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ PMA Pomerantzeff \n \t\t\t\t\t\t\t\t """ 1 => """ R Snitcovsky \n \t\t\t\t\t\t\t\t """ 2 => """ IV Trevisan \n \t\t\t\t\t\t\t\t """ 3 => """ MB Marcial \n \t\t\t\t\t\t\t\t """ 4 => """ G Verginelli \n \t\t\t\t\t\t\t\t """ 5 => """ AD Jatene \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cardiol Young" "fecha" => "1992" "volumen" => "2" "paginaInicial" => "244" "paginaFinal" => "246" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mitral valve repair in rheumatic disease. The flexible solution" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ JM Bernal \n \t\t\t\t\t\t\t\t """ 1 => """ JM Rabasa \n \t\t\t\t\t\t\t\t """ 2 => """ FG Vilchez \n \t\t\t\t\t\t\t\t """ 3 => """ JC Cagigas \n \t\t\t\t\t\t\t\t """ 4 => """ JM Revuelta \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.cir.88.4.1746" "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "1993" "volumen" => "88" "numero" => "1" "paginaInicial" => "1746" "paginaFinal" => "1753" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8403321" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Posterior pericardial annuloplasty: a physiological correction?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ M Salati \n \t\t\t\t\t\t\t\t """ 1 => """ R Scrofani \n \t\t\t\t\t\t\t\t """ 2 => """ C Santoli \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/1010-7940(91)90168-j" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "1991" "volumen" => "5" "paginaInicial" => "226" "paginaFinal" => "229" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1859660" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Posterior annuloplasty in the surgical treatment of mitral insufficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ A Pellegrini \n \t\t\t\t\t\t\t\t """ 1 => """ E Quaini \n \t\t\t\t\t\t\t\t """ 2 => """ T Colombo \n 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 24 | 13 | 37 |
| 2024 September | 41 | 13 | 54 |
| 2024 August | 40 | 14 | 54 |
| 2024 July | 48 | 20 | 68 |
| 2024 June | 37 | 20 | 57 |
| 2024 May | 62 | 12 | 74 |
| 2024 April | 43 | 11 | 54 |
| 2024 March | 46 | 14 | 60 |
| 2024 February | 41 | 14 | 55 |
| 2024 January | 45 | 8 | 53 |
| 2023 December | 30 | 18 | 48 |
| 2023 November | 41 | 19 | 60 |
| 2023 October | 43 | 25 | 68 |
| 2023 September | 22 | 25 | 47 |
| 2023 August | 19 | 9 | 28 |
| 2023 July | 10 | 14 | 24 |
| 2023 June | 17 | 11 | 28 |
| 2023 May | 30 | 0 | 30 |
| 2023 April | 32 | 5 | 37 |
| 2023 March | 28 | 0 | 28 |
| 2023 February | 5 | 1 | 6 |
| 2023 January | 2 | 2 | 4 |
| 2022 December | 9 | 0 | 9 |
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