CLINICAL SCIENCES
MULTICENTER STUDY OF PERIOPERATIVE EVALUATION FOR NONCARDIAC SURGERIES IN BRAZIL (EMAPO)
Claudio Pinho, Paulo C Grandini, Danielle M Gualandro, Daniela Calderaro, Maristela Monachini, Bruno Caramelli
Pontifical Catholic University of Campinas – Campinas/SP, Brazil.
Interdisciplinary Medicine in Cardiology Unit, Heart Institute, University of São Paulo - São Paulo/SP, Brazil.
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"identificador" => "aff1" ] 1 => array:2 [ "entidad" => "Interdisciplinary Medicine in Cardiology Unit, Heart Institute, University of São Paulo - São Paulo/SP, Brazil." "identificador" => "aff2" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2616 "Ancho" => 2045 "Tamanyo" => 665219 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Risk factors for perioperative complications and respective points in the EMAPO project</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para10" class="elsevierStylePara elsevierViewall">There were 2,747,254 hospitalizations for surgical interventions in Brazil in 2000. The mortality rate associated with these hospitalizations was 2.1%, and the average period of hospitalization was 4.6 days, generating a cost of roughly 750 million dollars.<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a> In the United States, 3% to 10% of the patients undergoing surgical intervention have some sort of complication, and of the deaths that occur in the postoperative period, 40% have a cardiovascular cause.<a class="elsevierStyleCrossRef" href="#bib2"><span class="elsevierStyleSup">2</span></a></p><p id="para20" class="elsevierStylePara elsevierViewall">Perioperative evaluation consists of a set of medical procedures performed before, during, and after the surgery to establish the degree of risk and to propose strategies for reducing the incidence of cardiovascular complications.<a class="elsevierStyleCrossRefs" href="#bib3"><span class="elsevierStyleSup">3–26</span></a> The existing evaluation methods are based on studies that consider the impact of clinical and surgical characteristics on the postoperative evolution. The currently available evaluation methods have limitations because they leave out certain diseases, do not adopt modern diagnostic criteria and treatment options for others, and do not consider the extent of the surgery or the functional capacity. The accuracy of these methods is better than chance, but their performance is not ideal. The American College of Physicians (ACP) method is the most widely used method internationally, but it also has problems,<a class="elsevierStyleCrossRef" href="#bib6"><span class="elsevierStyleSup">6</span></a> eg, the wide range of different risk levels—particularly that of the intermediate level—in which different patients with clearly different risk profiles are classified in the same category.</p><p id="para30" class="elsevierStylePara elsevierViewall">The objectives of this study were to determine the risk profile and the incidence of perioperative complications in a Brazilian population and to compare an international evaluation method (ACP) with a new one called EMAPO (Multicenter Study of Perioperative Evaluation), which considers diseases that were not mentioned in the previous guidelines and modern treatment options in order to determine new clinical variables associated with cardiovascular complications.</p><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">Population</span><p id="para40" class="elsevierStylePara elsevierViewall">After approval by the local ethics committee, all consecutive patients older than 15 years referred for noncardiac surgeries, for whom perioperative evaluation was requested in the period between February 2001 and May 2002 in 3 centers (1 university hospital and 2 private clinics: Hospital das Clínicas, São Paulo University Medical School, Clinicor Clinic of Ribeirão Preto, and Ritmocordis Clinics of Valinhos) were studied. Patients who did not undergo surgery for any reason were excluded.</p></span></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">METHODS</span><p id="para50" class="elsevierStylePara elsevierViewall">The patients were evaluated through the method proposed by the EMAPO Project (Multicenter Study of Perioperative Evaluation of SOCESP – Society of Cardiology of the State of São Paulo). This method proposes calculating the cardiovascular risk index by adding the accumulated points that correspond to the presence of risk factors described previously and new variables that were added based on the clinical experience of the authors (Appendix).<a class="elsevierStyleCrossRefs" href="#bib5"><span class="elsevierStyleSup">5,6,27</span></a> Additionally, EMAPO proposes a new classification, stratifying the perioperative risk into 5 levels according to the expected complication rate (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>).</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para60" class="elsevierStylePara elsevierViewall">The same population was also evaluated using the American College of Physicians (ACP) criteria, which stratifies the perioperative risk into 3 levels according to the expected complication rate.<a class="elsevierStyleCrossRef" href="#bib6"><span class="elsevierStyleSup">6</span></a></p><p id="para70" class="elsevierStylePara elsevierViewall">The patients were monitored until discharge, and cardiac events and deaths were recorded. The cardiac events considered were ischemic events (unstable angina and myocardial infarction), embolic events, cardiac arrhythmias, and others. Cardiac events were defined as previous reported.<a class="elsevierStyleCrossRef" href="#bib8"><span class="elsevierStyleSup">8</span></a></p><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle160">Statistical Analysis</span><p id="para80" class="elsevierStylePara elsevierViewall">We estimated that the sample to be studied should have roughly 700 individuals. The risk variables were descriptively analyzed, and their relationship to the occurrence of perioperative cardiac complications was subsequently verified. Although some patients presented more than 1 complication, such patients were reckoned in the same manner as patients with a single complication. The chi-square method was used for this first analysis. Multivariate analysis was performed based on the variables identified in the univariate model. A <span class="elsevierStyleItalic">P</span> value lower than or equal to 0.05 was considered statistically significant.</p><p id="para90" class="elsevierStylePara elsevierViewall">Both methods were then compared according to criteria of sensitivity and specificity using the areas under the receiver operating characteristic (ROC) curve.<a class="elsevierStyleCrossRefs" href="#bib28"><span class="elsevierStyleSup">28–30</span></a></p></span></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle170">RESULTS</span><p id="para100" class="elsevierStylePara elsevierViewall">Seven hundred patients with a mean age of 56 years (18 to 96 years) were evaluated. The majority of these patients were women (59.1%), and the presence of clinically detectable cardiac disease was described in 52%. Regarding the type of surgery, 95% were elective, 4% urgent, and 0.4% emergency surgery. The average hospitalization period was 3.6 days (1 to 72 days).</p><p id="para110" class="elsevierStylePara elsevierViewall">The evaluation with the EMAPO method yielded a mean score of 3.5 points (within a range of 0 to 33), and patients with low and very low risk prevailed (83%). The evaluation of the same sample by the ACP method resulted in a mean score of 2.0 points (0 to 20) and the patients with low risk (94.4%) also prevailed.</p><p id="para120" class="elsevierStylePara elsevierViewall">The mortality rate was 3.4%. Perioperative complications were observed in 64 patients (9.1%). There were 42 cardiovascular events in 37 patients (5.3%) as follows: 16 ischemic, 10 arrhythmic, 6 embolic, 2 congestive, and 8 nonspecified cardiovascular etiologies. Among the patients that presented complications, 37.5% died (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>).</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><p id="para130" class="elsevierStylePara elsevierViewall">The significance of the variables used in the EMAPO questionnaire regarding the existence of cardiac complications during the perioperative period was determined. In the univariate analysis, the statistically significant variables were detectable cardiopathy, poor general medical status (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>), urea > 50 mg/dL or creatinine > 2.3 mg/dL, emergency surgery, major surgery, surgery duration > 4 hours, blood loss > 1000 mL, hospitalization > 3 days, chronic coronary disease with negative noninvasive stress testing (less than 3 months), male gender, general anesthesia, myocardial infarction < 6 months, aortic aneurism, and age > 70 years. In the multivariate analysis, the variables related to renal failure (<span class="elsevierStyleItalic">P</span> = 0.016), major surgery (<span class="elsevierStyleItalic">P</span> = 0.004), and emergency surgery (<span class="elsevierStyleItalic">P</span> = 0.03) remained significant.</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para140" class="elsevierStylePara elsevierViewall">The ROC curves derived from patient data according to EMAPO and ACP methods were analyzed. In order for the two methods to be compared, the 5 levels of the EMAPO method were grouped in 3 categories: very low and low risks were compared with the ACP low risk; moderate was compared with the ACP intermediate risk; elevated and very elevated were compared with the ACP high risk. The ROC curves are represented in <a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>.</p><elsevierMultimedia ident="fig2"></elsevierMultimedia><p id="para150" class="elsevierStylePara elsevierViewall">The comparison of the two methods showed that the areas did not differ and there was no significant difference between them in predicting the occurrence of cardiovascular complications. Besides that, new variables related to surgical risk were identified, such as male gender, aortic aneurysm and major surgery.</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle180">DISCUSSION</span><p id="para160" class="elsevierStylePara elsevierViewall">The majority of patients in our study was classified within the low risk group for perioperative cardiovascular complications. Nevertheless, we observed a high overall incidence of perioperative cardiovascular complications (5.3%). The accuracy of perioperative evaluation methods available today is low, limiting our ability to take measures that would reduce cardiovascular complications. Gilbert et al compared the perioperative evaluation methods used in clinical practice in 2035 patients. These methods were the ACP, the American Society of Anesthesiologists Index (ASA), the Canadian Cardiovascular Society Index, and the Goldman Index. In this population, 30% of the patients underwent low risk surgeries (ophthalmologic, superficial, and endoscopic), and cardiac complications occurred in 6.4% of patients. By comparing the accuracy of the methods using the ROC curve analysis, the authors concluded that all of them have limited accuracy and no method was better than the others. The authors suggest that more efficient methods are needed to prevent the occurrence of perioperative cardiovascular complications and that other clinical variables should be considered during the evaluation of risk.<a class="elsevierStyleCrossRef" href="#bib31"><span class="elsevierStyleSup">31</span></a> Consequently, we tried to create a new score to predict cardiac complications.</p><p id="para170" class="elsevierStylePara elsevierViewall">Existing methods of perioperative evaluation were developed by choosing variables previously described in the literature as predictors of perioperative events and giving points in order to create a score. The EMAPO was designed by updating variable definitions and adding new ones based on clinical experience, and it was as good as the ACP method in predicting cardiac events. Additionally, in the EMAPO model, major surgery was significant as a predictor of cardiac complications; this variable is not considered in the ACP model.</p><p id="para180" class="elsevierStylePara elsevierViewall">The intermediate risk of the ACP model includes patients with a wide risk range (chance of cardiac complications between 3% and 15%). By proposing an extra 2 risk levels for cardiovascular complications, the EMAPO method intended to split the two most important strata, low risk and high risk, into 2 groups to disclose the differences in these very heterogeneous groups. However, this strategy failed, since no increased risk levels were identified, probably because of the relatively small number of patients in each group. Although the efficacy of EMAPO is similar to that of ACP, the execution of the former is more complex because of the number of items and consequently the amount of information needed. Besides that, as this is a new score, there are no guidelines regarding the strategy to be taken in order to minimize the cardiac risk for each category of patients.</p><p id="para190" class="elsevierStylePara elsevierViewall">As the cost of hospital expenditures increases, the reduction of perioperative complication incidence becomes mandatory, because complications often result in a longer hospitalization period and in subsidiary exams and other medical interventions.<a class="elsevierStyleCrossRefs" href="#bib3"><span class="elsevierStyleSup">3,7,8,32</span></a></p><p id="para200" class="elsevierStylePara elsevierViewall">More studies are needed to improve our ability to determine which patient has more cardiac risk after noncardiac surgery. The division of the intermediate risk into a more narrow risk range may be the first stage in this direction.</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle190">ACKNOWLEDGEMENTS</span><p id="para210" class="elsevierStylePara elsevierViewall">To SOCESP – Sociedade de Cardiologia do Estado de São Paulo (Society of Cardiology of the State of São Paulo), for the support given for the execution of this clinical study.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "xpalclavsec1584833" "titulo" => "KEYWORDS" ] 1 => array:3 [ "identificador" => "xres1815182" "titulo" => "RESUMO" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "ceabs60" "titulo" => "INTRODUÇÃO:" ] 1 => array:2 [ "identificador" => "ceabs70" "titulo" => "OBJETIVOS:" ] 2 => array:2 [ "identificador" => "ceabs80" "titulo" => "MÉTODOS:" ] 3 => array:2 [ "identificador" => "ceabs90" "titulo" => "RESULTADOS:" ] 4 => array:2 [ "identificador" => "ceabs100" "titulo" => "CONCLUSÕES:" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1584834" "titulo" => "UNITERMOS:" ] 3 => array:2 [ "identificador" => "cesec10" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "cesec20" "titulo" => "Population" ] ] ] 4 => array:3 [ "identificador" => "cesec30" "titulo" => "METHODS" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "cesec40" "titulo" => "Statistical Analysis" ] ] ] 5 => array:2 [ "identificador" => "cesec50" "titulo" => "RESULTS" ] 6 => array:2 [ "identificador" => "cesec60" "titulo" => "DISCUSSION" ] 7 => array:2 [ "identificador" => "cesec70" "titulo" => "ACKNOWLEDGEMENTS" ] 8 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-08-08" "fechaAceptado" => "2006-10-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1584833" "palabras" => array:5 [ 0 => "Cardiac risk" 1 => "Noncardiac surgery" 2 => "Algorithms" 3 => "Cardiovascular complications" 4 => "Risk factors" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "UNITERMOS:" "identificador" => "xpalclavsec1584834" "palabras" => array:5 [ 0 => "Avaliação perioperatória" 1 => "Risco cardíaco" 2 => "Algorítimos" 3 => "Fatores de risco" 4 => "Complicações cardiovasculares" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">INTRODUCTION:</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">The accuracy of perioperative evaluation methods available is better than chance, but their performance is not ideal.</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">OBJECTIVES:</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">To compare a new evaluation method (EMAPO) to the American College of Physicians method for determining the risk of cardiovascular complications in noncardiac surgeries and to look for new influencing variables.</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">METHODS:</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">Evaluations through EMAPO and the American College of Physicians method were employed for 700 patients. Cardiac events and deaths were recorded, the risk variables related to the occurrence of complications were verified, and the models were compared by analyzing the areas under the receiver operating characteristic curves.</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">RESULTS:</span><p id="spara110" class="elsevierStyleSimplePara elsevierViewall">Mortality rate was 3.4%, and the incidence of cardiovascular complications was 5.3%. Renal failure (<span class="elsevierStyleItalic">P</span> = 0.01), major surgery (<span class="elsevierStyleItalic">P</span> = 0.004), and emergency surgery (<span class="elsevierStyleItalic">P</span> = 0.003) were independently related to the occurrence of cardiovascular complications. The two methods produced similar results.</p></span> <span id="ceabs50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">CONCLUSION:</span><p id="spara120" class="elsevierStyleSimplePara elsevierViewall">EMAPO is as good as the American College of Physicians method in determining the risk of cardiovascular complications in noncardiac surgeries. New variables related to surgical risk were identified.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "INTRODUCTION:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "OBJECTIVES:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "METHODS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "RESULTS:" ] 4 => array:2 [ "identificador" => "ceabs50" "titulo" => "CONCLUSION:" ] ] ] "pt" => array:3 [ "titulo" => "RESUMO" "resumen" => "<span id="ceabs60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">INTRODUÇÃO:</span><p id="spara130" class="elsevierStyleSimplePara elsevierViewall">A precisão dos métodos de avaliação perioperatória disponíveis é melhor que o acaso, porém está longe do ideal.</p></span> <span id="ceabs70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">OBJETIVOS:</span><p id="spara140" class="elsevierStyleSimplePara elsevierViewall">Comparar um novo método de avaliação perioperatória (EMAPO) ao método do American College of Physicians para determinar o risco cardíaco em cirurgias não cardíacas e buscar novas variáveis envolvidas na determinação deste risco.</p></span> <span id="ceabs80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">MÉTODOS:</span><p id="spara150" class="elsevierStyleSimplePara elsevierViewall">O EMAPO e o método do American College of Physicians foram aplicados em 700 pacientes. A ocorrência de eventos cardíacos e de mortes foi documentada, a relação entre as variáveis de risco e as complicações foi estabelecida e os métodos foram comparados analisando as áreas sob a curva ROC.</p></span> <span id="ceabs90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">RESULTADOS:</span><p id="spara160" class="elsevierStyleSimplePara elsevierViewall">A mortalidade foi 3.4% e a incidência de complicações cardiovasculares 5.3%. A presença de insuficiência renal (p=0.01), cirurgia de grande porte (p=0.004) e cirurgia de emergência (p=0.003) se correlacionaram com a ocorrência de complicações cardiovasculares na análise multivariada. Não houve diferença entre os dois métodos.</p></span> <span id="ceabs100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">CONCLUSÕES:</span><p id="spara170" class="elsevierStyleSimplePara elsevierViewall">O EMAPO é tão eficaz quanto o método do American College of Physicians para determinar o risco de complicações cardiovasculares em cirurgias não cardíacas. Novas variáveis relacionadas com o risco perioperatório foram encontradas.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "ceabs60" "titulo" => "INTRODUÇÃO:" ] 1 => array:2 [ "identificador" => "ceabs70" "titulo" => "OBJETIVOS:" ] 2 => array:2 [ "identificador" => "ceabs80" "titulo" => "MÉTODOS:" ] 3 => array:2 [ "identificador" => "ceabs90" "titulo" => "RESULTADOS:" ] 4 => array:2 [ "identificador" => "ceabs100" "titulo" => "CONCLUSÕES:" ] ] ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2616 "Ancho" => 2045 "Tamanyo" => 665219 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Risk factors for perioperative complications and respective points in the EMAPO project</p>" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 815 "Ancho" => 993 "Tamanyo" => 90649 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">ROC (receiver operating characteristic) curves according to the results from EMAPO and ACP evaluations</p>" ] ] 2 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">EMAPO = Multicenter Study of Perioperative Evaluation</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Risk Status \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Total Score \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Expected Cardiac Complications \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Very low \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">< 1% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Low \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Up to 5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">< 3% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Moderate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">From 6 to 10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">< 7% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Elevated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">From 11 to 15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7% –13% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Very elevated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Above 15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">> 13% \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Complication risk index according to the EMAPO</p>" ] ] 3 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">EMAPO = Multicenter Study of Perioperative Evaluation</p><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">ACP = American College of Physicians method</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Risk \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">EMAPO Patients (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">CC (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">ACP Patients (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">CC (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Very Low \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">370 (52.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11/370 (3.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">_____ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">_____ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Low \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">211 (30.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12/211 (5.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">661 (94.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34/661 (5.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Moderate / Intermediate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64 (9.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10/64 (15.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 (5.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/35 (5.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Elevated / High \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 (5.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/37 (2.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/4 (25.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Very Elevated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 (2.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/18 (16.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">_____ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">_____ \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Risk level classification and cardiovascular complications (CC)</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ministério da Saúde; SUS – DATASUS – Morbidade. www.datasus.gov.br (Accessed 20/08/2002)." ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation and treatment of the perioperative patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ HU Simon \n \t\t\t\t\t\t\t\t """ 1 => """ AS Blaustein \n \t\t\t\t\t\t\t\t """ 2 => """ LF Wexler \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "MHCrawford" "titulo" => "Current diagnosis & treatment in cardiology" "paginaInicial" => "595" "paginaFinal" => "609" "edicion" => "2<span class="elsevierStyleSup">nd</span> ed" "serieFecha" => "2003" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ DT Mangano \n \t\t\t\t\t\t\t\t """ 1 => """ EL Layug \n \t\t\t\t\t\t\t\t """ 2 => """ A Wallace \n \t\t\t\t\t\t\t\t """ 3 => """ I Tateo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199612053352301" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 0 | 10 |
| 2024 October | 54 | 29 | 83 |
| 2024 September | 26 | 13 | 39 |
| 2024 August | 27 | 14 | 41 |
| 2024 July | 18 | 16 | 34 |
| 2024 June | 25 | 13 | 38 |
| 2024 May | 21 | 10 | 31 |
| 2024 April | 24 | 12 | 36 |
| 2024 March | 14 | 14 | 28 |
| 2024 February | 15 | 11 | 26 |
| 2024 January | 18 | 14 | 32 |
| 2023 December | 12 | 20 | 32 |
| 2023 November | 11 | 19 | 30 |
| 2023 October | 17 | 22 | 39 |
| 2023 September | 22 | 26 | 48 |
| 2023 August | 20 | 6 | 26 |
| 2023 July | 21 | 17 | 38 |
| 2023 June | 13 | 8 | 21 |
| 2023 May | 33 | 2 | 35 |
| 2023 April | 33 | 2 | 35 |
| 2023 March | 25 | 1 | 26 |
| 2023 February | 3 | 1 | 4 |
| 2023 January | 0 | 2 | 2 |
| 2022 December | 7 | 0 | 7 |
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