PRENATAL DIAGNOSIS AND PERINATAL OUTCOME OF 38 CASES WITH CONGENITAL DIAPHRAGMATIC HERNIA: 8-YEAR EXPERIENCE OF A TERTIARY BRAZILIAN CENTER

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Netto, Pedro Puech-Leão" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Lívio" "apellidos" => "Nakano" ] 1 => array:2 [ "nombre" => "Nelson" "apellidos" => "Wolosker" ] 2 => array:2 [ "nombre" => "Ruben Ayzin" "apellidos" => "Rosoki" ] 3 => array:2 [ "nombre" => "Baptista Muraco" "apellidos" => "Netto" ] 4 => array:2 [ "nombre" => "Pedro" "apellidos" => "Puech-Leão" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222032574?idApp=UINPBA00004N" "url" => "/18075932/0000006100000003/v1_202212060845/S1807593222032574/v1_202212060845/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "ORIGINAL RESEARCH" "titulo" => "PRENATAL DIAGNOSIS AND PERINATAL OUTCOME OF 38 CASES WITH CONGENITAL DIAPHRAGMATIC HERNIA: 8-YEAR EXPERIENCE OF A TERTIARY BRAZILIAN CENTER" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "197" "paginaFinal" => "202" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Rodrigo Ruano, Victor Bunduki, Marcos Marques Silva, Carlos Tadashi Yoshizaki, Uenis Tanuri, João Gilberto Macksoud, Marcelo Zugaib" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Rodrigo" "apellidos" => "Ruano" "email" => array:1 [ 0 => "rodrigoruano@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "Victor" "apellidos" => "Bunduki" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Marcos Marques" "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Carlos Tadashi" "apellidos" => "Yoshizaki" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Uenis" "apellidos" => "Tanuri" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "João Gilberto" "apellidos" => "Macksoud" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 6 => array:3 [ "nombre" => "Marcelo" "apellidos" => "Zugaib" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Obstetrics and Gynecology, Hospital das Clínicas, São Paulo University Medical School." "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Pediatric Surgery Department, Hospital das Clínicas, São Paulo University Medical School." "etiqueta" => "b" "identificador" => "aff2" ] ] ] ] "textoCompleto" => "INTRODUCTIONCongenital diaphragmatic hernia (CDH) - consisting of a diaphragmatic defect that starts early in the embryological period, with consequent herniation of the abdominal structures into thoracic cavity - occurs in approximately 1 of 2,200 live births.<a class="elsevierStyleCrossRefs" href="#bib1">1,2</a> Herniated abdominal structures, such as stomach and liver, shift fetal lungs, and cause pulmonary hypoplasia, which is responsible for the high neonatal mortality rate.<a class="elsevierStyleCrossRef" href="#bib3">3</a> Although the lungs are shifted during fetal life, the placenta maintains respiratory function, allowing correct gas exchange. However, once the umbilical cord is clamped during birth, the hypoplastic lungs cannot perform adequate gas exchange, leading to severe respiratory distress and neonatal death.<a class="elsevierStyleCrossRef" href="#bib4">4</a>Prenatal diagnosis has improved neonatal outcome worldwide through diagnosis of other associated malformations, excluding chromosomal abnormalities, and planning delivery inside a specialized tertiary center.<a class="elsevierStyleCrossRef" href="#bib5">5</a> Before the onset of prenatal sonographic diagnosis, the mortality rate was almost 100%, and CDH was considered a lethal malformation.<a class="elsevierStyleCrossRef" href="#bib6">6</a> Nowadays, the mortality rate has been decreasing among neonates with isolated CDH, varying from 40% to 75% in developed countries.<a class="elsevierStyleCrossRefs" href="#bib1">1,7</a> Nevertheless, in spite of the great advances in prenatal and postnatal diagnosis and management, the mortality rate in neonates with isolated CDH is still high.<a class="elsevierStyleCrossRef" href="#bib8">8</a>Recent research has focused on prenatal predictors of neonatal outcome in isolated CDH cases, such as lung/head ratio<a class="elsevierStyleCrossRefs" href="#bib9">9,10</a> and fetal lung volume,<a class="elsevierStyleCrossRefs" href="#bib11">11–16</a> to differentiate cases with a worse prognosis, in which fetal therapy or termination of pregnancy may be indicated, from those with better prognosis, requiring only specialized postnatal care.<a class="elsevierStyleCrossRefs" href="#bib17">17–19</a>In spite of the worldwide, published experience, there are no data about perinatal results in cases of prenatally diagnosed CDH in Brazil. Therefore, we reviewed all cases of prenatally diagnosed CDH in a specialized tertiary center, focusing on the frequency of associated structural malformations, chromosomal abnormalities, and the mortality rate.PATIENTS AND METHODSWe reviewed the prenatal database from January 1995 to December 2003 of the Fetal Medicine Unit of the Department of Obstetrics and Gynecology, São Paulo University Medical School, identifying 38 cases of CDH.Prenatal characteristics were retrospectively analyzed from the ultrasonographic basic database. The main data analyzed were gestational age at diagnosis, presence of associated structural malformations, fetal karyotyping, side of diaphragmatic defect, mediastinal shift, and liver herniation.Perinatal outcome was reviewed by consulting prenatal, neonatal, and pediatric databases, as well as from telephone contacts with parents. Cases were classified according to perinatal outcome including fetal death, early neonatal death (from birth to 7 days of life), and late neonatal death (after 7 days of life up to 28 days).RESULTSAmong the 38 cases of CDH, 30 (79%) had left CDH, and 8 (21%) had right CDH. Mean gestational age at diagnosis was 29 weeks of gestation (range, 16-37 weeks). Associated structural malformations were observed in 21 cases (55%), of which 12 had normal karyotyping (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>). Chromosomal abnormality was observed in 9 cases (24%), including trisomy 18 (n = 4), trisomy 13 (n = 3), 46XX/47XXX (n = 1), and 45X (n = 1). These two last fetuses had heart malformations in association with congenital diaphragmatic hernia (interventricular defect and aorta coarctation, respectively).<elsevierMultimedia ident="tbl1"></elsevierMultimedia>The overall mortality was 92% (35/38). All cases with chromosomal abnormalities died before the 7th day of life (mortality of 100%). Among the 12 cases with associated structural malformation but normal karyotyping, 11 (92%) also died before the 7th day of life (including fetal deaths). Among all the cases, only 3 infants with CDH survived more than 28 days after surgical repair (including 1 neonate with associated omphalocele, but with a normal karyotype) (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>).<elsevierMultimedia ident="tbl2"></elsevierMultimedia>Isolated CDH was observed in 17 cases (45%). In this group, 15 neonates (88%) died. No fetal death was observed, 2 neonates (12%) survived up to the 28th day of life and 2 neonates (12%) survived after the 28th day of life (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>). Two (12%) neonates underwent surgical repair after satisfactory ventilatory condition and preoperative stabilization between 10 and 22 days of life. Among the neonates with isolated CDH, the diaphragmatic defect was on the left in 12 (71%) and on the right in 5 (29%). Herniated liver and major mediastinal shift were observed in 7 (41%) and 13 cases (77%), respectively. All neonates with a herniated liver or right-sided CDH died before the 7th day of life. Among 13 neonates with major mediastinal shift, early death occurred in 10 (77%), while it occurred in 2 of 4 (50%) without this occurrence (<a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>).<elsevierMultimedia ident="tbl3"></elsevierMultimedia>DISCUSSIONThe results demonstrate that other structural abnormalities are frequently associated with CDH and that perinatal mortality remains very high, even in neonates with isolated CDH. In this series, because termination of pregnancy (TOP) was not performed, it was possible to evaluate the natural history of CDH in cases with associated structural malformations, chromosomal abnormalities, and even in isolated CDH cases.Published reports place the incidence of chromosomal and structural abnormalities in association with CDH at 35% to 50%, including trisomies, most commonly trisomy 18.<a class="elsevierStyleCrossRefs" href="#bib20">20–22</a> In this study, 55% of the neonates had associated malformations, and 24% had chromosomal abnormalities. All neonates with chromosomal abnormalities had other associated structural malformations. Among the neonates with abnormal karyotyping, trisomies 18 and 13 were diagnosed in 4 (44%) and 3 (33%) cases, respectively. Cases with abnormal karyotyping usually have the poorest prognosis, with 100% perinatal mortality, typically earlier, because fetal death occurred more often (56%). In neonates with associated structural malformation but normal karyotype, perinatal mortality was also very high (92%). This particular group contributed to the very high perinatal mortality observed in our study, mainly to the earlier deaths, ie, fetal demise (42%) and early neonatal deaths (58%). One infant who had an associated omphalocele and normal karyotype survived, probably because of the mild or less severe herniation of abdominal organs into the fetal thorax, leading to milder compression of mediastinal structures and lungs. Both groups are candidates for medical termination of pregnancy (TOP) in countries where this is allowed by the local law.In cases with isolated CDH, perinatal mortality was higher in our series (88%) than reported in the international literature (50–70%).<a class="elsevierStyleCrossRefs" href="#bib23">23,24</a> This could be explained by many factors. First, in our series there was no TOP, while in the international literature, TOP was performed in about 20% to 30% of cases.<a class="elsevierStyleCrossRef" href="#bib1">1</a> Second, the main prognostic factor considered was the pulmonary size and/or volume, which is evaluated by the lung-over-head ratio (LOHR)<a class="elsevierStyleCrossRefs" href="#bib9">9,10</a> and the observed/expected fetal lung volume ratio (o/e-FLV).<a class="elsevierStyleCrossRefs" href="#bib12">12,13,16</a> Cases with LOHR < 1.0 and o/e-FLV < 0.35 are associated with poorer outcome (approximately 90%). In many countries, TOP is performed in cases that have a poorer prognosis, with LOHR < 1.0, right defect, and liver herniation. In our series, these parameters were not evaluated; therefore, it is not possible to state whether they are similar or comparable populations.Another possible contributing factor to this difference in perinatal mortality rates is that we included in our study only prenatally diagnosed cases, which are known to have a higher mortality rate than those with only postnatal diagnosis. Skari et al<a class="elsevierStyleCrossRef" href="#bib1">1</a> observed that neonatal mortality is 2 to 4 times higher in prenatally diagnosed than in postnatally diagnosed series. This possibility is supported when the neonatal mortality of 88% in our series is considered in the context of the 40% mortality reported in a previous study published by pediatric surgeons from our hospital; in that study, CDH was diagnosed postnatally.<a class="elsevierStyleCrossRef" href="#bib25">25</a>Additionally, Harrison et al<a class="elsevierStyleCrossRef" href="#bib17">17</a> recently demonstrated that adequate and specialized neonatal care can improve neonatal survival to about 70% in cases with prenatally diagnosed isolated CDH, even in those cases without prenatal treatment. This finding means that each hospital may have different neonatal mortality rates based on the prenatal selection of population, prenatal interventions, degree of specialization of neonatal care group, and type of postnatal treatment. Consequently, meta-analysis and multicenter studies have important inbuilt bias and must be analyzed carefully. Nevertheless, in our series, right-sided lesion as well as major mediastinal shift and herniated liver were more frequently observed in neonates who died before 7 days of life, and these factors have also been related to a poorer outcome in other studies.<a class="elsevierStyleCrossRefs" href="#bib1">1,5,7–16</a>By analyzing the natural history of CDH, the present study is important for demonstrating that each hospital may experience different neonatal mortality rates in isolated CDH. It also motivates us to review our neonatal care and our prenatal evaluation of prognosis as well as to consider fetal interventions in selected cases. By improving the neonatal care and prenatal prediction of perinatal outcome in cases with isolated CDH, minimal fetal invasive surgery could be indicated for those cases with a worse prognosis, based on the fact that we cannot offer TOP to those patients." "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1585082" "titulo" => "KEYWORDS" ] 1 => array:3 [ "identificador" => "xres1815429" "titulo" => "RESUMO" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs50" "titulo" => "OBJETIVO:" ] 1 => array:2 [ "identificador" => "ceabs60" "titulo" => "PACIENTES E MÉTODOS:" ] 2 => array:2 [ "identificador" => "ceabs70" "titulo" => "RESULTADOS:" ] 3 => array:2 [ "identificador" => "ceabs80" "titulo" => "CONCLUSÃO:" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1585083" "titulo" => "UNITERMOS:" ] 3 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 4 => array:2 [ "identificador" => "cesec20" "titulo" => "PATIENTS AND METHODS" ] 5 => array:2 [ "identificador" => "cesec30" "titulo" => "RESULTS" ] 6 => array:2 [ "identificador" => "cesec40" "titulo" => "DISCUSSION" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-09-26" "fechaAceptado" => "2006-02-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1585082" "palabras" => array:5 [ 0 => "Ultrasound" 1 => "Congenital diaphragmatic hernia" 2 => "Neonatal mortality" 3 => "Prenatal diagnosis" 4 => "Fetal malformation" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "UNITERMOS:" "identificador" => "xpalclavsec1585083" "palabras" => array:5 [ 0 => "Ultra-sonografia" 1 => "Hérnia diafragmática congénita" 2 => "Mortalidade neonatal" 3 => "Diagnóstico pré-natal" 4 => "Malformação fetal" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "resumen" => "PURPOSE:To evaluate the perinatal results for neonates with congenital diaphragmatic hernia diagnosed prenatally. METHOD:We reviewed data from 38 cases of congenital diaphragmatic hernia diagnosed prenatally from January 1995 to December 2003 in the Fetal Medicine Unit of the Department of Obstetrics and Gynecology, São Paulo University Medical School. The main data analyzed were gestational age at diagnosis, fetal karyotyping, side of diaphragmatic defect, presence of associated structural malformations, hepatic herniation, and severe mediastinal shift. Perinatal outcomes were obtained by reviewing hospital documents or by directly calling the patients’ immediate relatives. RESULTS:Mean gestational age at diagnosis was 29 weeks (range, 16-37 weeks). Thirty (79%) cases had a left diaphragmatic defect and 8 (21%) had a right lesion. Associated structural malformations were observed in 21 (55%) cases, in which 12 fetuses had a normal karyotype and 9 had chromosomal abnormalities. Isolated congenital diaphragmatic hernia was confirmed in 17 (45%) cases. The overall perinatal mortality rate was 92%. Rates of fetal deaths, early neonatal deaths, late neonatal deaths, and survival were 42%, 50%, 0%, and 8%, respectively, in cases with associated structural malformations but normal karyotyping; 56%, 44%, 0%, and 0% for cases with chromosomal abnormalities; and, 0%, 76%, 12%, and 12% in cases with isolated congenital diaphragmatic hernia. The neonatal mortality rate was 89% in cases with isolated congenital diaphragmatic hernia. CONCLUSION:Perinatal mortality was very high in prenatally diagnosed cases of congenital diaphragmatic hernia. Earlier perinatal deaths are associated with the presence of other structural defects or chromosomal abnormalities. In cases of isolated congenital diaphragmatic hernia, mortality is related to the presence of herniated liver, right-sided lesion, and major mediastinal shift." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "PURPOSE:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHOD:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSION:" ] ] ] "pt" => array:3 [ "titulo" => "RESUMO" "resumen" => "OBJETIVO:Avaliar os resultados neonatais dos casos de hérnia diafragmática congênita com diagnóstico pré-natal. PACIENTES E MÉTODOS:De janeiro de 1995 a dezembro de 2003 foram revisados os dados de 38 fetos com hérnia diafragmática diagnosticada durante o período pré-natal na Unidade de Medicina Fetal do Departamento de Obstetrícia e Ginecologia da Faculdade de Medicina da Universidade de São Paulo. Os dados pré-natais analisados foram: idade gestacional no diagnóstico, cariótipo fetal, lado da lesão, presença de malformação estrutural associada, herniação hepática e desvio garve de mediastino. Os dados perinatais foram avaliados consultando os prontuários médicos ou por contato telefônico. RESULTADOS:A idade gestacional média no diagnóstico foi de 29 semanas (16-37). Trinta (79%) casos apresentavam lesão à esquerda e 8 (21%) à direita. Malformações estruturais associadas foram observadas em 21 (55%) casos, dos quais 12 fetos apresentaram cariótipo normal, enquanto 9 exibiram anomalias cromossômicas. Hérnia diafragmática isolada foi identificada em 17 (457%) casos. A taxa de mortalidade geral foi de 92%. A taxa de óbito fetal, neomorto precoce, neomorto tardio e sobrevivente após 28 dias de vida foram respectivamente: (i) para o grupo com malformação estrutural associada e cariótipo normal, de 42%, 50%, 0% e 8%; (ii) para os casos com cromos-somopatia, de 56%, 44%, 0% e 0%; (iii) para os casos com lesões isoladas de 0%, 76%, 12% e 12%. Na hérnia diafragmática congênita isolada, a mortalidade neonatal foi de 88%. CONCLUSÃO:Em nosso serviço, a mortalidade perinatal nos casos de hérnia diafragmática diagnosticada durante o pré-natal é muito alta. Óbitos neonatais precoces estão associados com presença de outros defeitos estruturais ou anomalias cromossômicas. Nos casos de HDC isolada, a mortalidade está relacionada à presença de fígado herniado, lado direito da lesão e desvio grave de mediastino." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs50" "titulo" => "OBJETIVO:" ] 1 => array:2 [ "identificador" => "ceabs60" "titulo" => "PACIENTES E MÉTODOS:" ] 2 => array:2 [ "identificador" => "ceabs70" "titulo" => "RESULTADOS:" ] 3 => array:2 [ "identificador" => "ceabs80" "titulo" => "CONCLUSÃO:" ] ] ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">CASE \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">STRUCTURAL MALFORMATION \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">KARYOTYPING \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Onphalocele \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XX \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Renal dysplasia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XX \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Spina bifida \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XY \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Occipital ecephalocele \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XY \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Heart defect (Fallot) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XY \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dandy Walker \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XY \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Type III adenomatoid malformation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XX \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dandy Walker and heart defect \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XY \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Occipital encephalocele and heart defect \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XY \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hydrocephaly and renal agenesy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XX \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Spine bifida and left kidney agenesy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XX \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Renal dysplasia and heart defect \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 XY \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Description of the associated structural malformations with normal karyotype" ] ] 1 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "CDH: congenital diaphragmatic hernia; MF: structural malformation; early NND: neonatal death before 7 days of life; late NND: neonatal deaths between 7 and 28 days of life; Survival: cases that survived after 28 days of life" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Fetal deathn (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">early NNDn (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">late NNDn (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Survivaln (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Totaln (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Isolated CDH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (76.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (11.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (11.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Associated MF with normal karyotype \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (41.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (50.0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (8.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chromosomal abnormalities \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (55.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (44.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Perinatal outcome in cases with congenital diaphragmatic hernia according to associated structural and chromosomal abnormalities" ] ] 2 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "CDH: congenital diaphragmatic hernia; early NND: neonatal death before 7 days of life; late NND: neonatal deaths between 7 and 28 days of life; Survival: infants that survived after 28 days of life." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">early NND \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">late NND \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">survival \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Side of CDH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">left CDH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">rigth CDH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Herniated liver \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">present \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">absent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Major mediastinal shift \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">present \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">absent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Outcome for neonates with isolated CDH, by prenatal ultrasonographic findings" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital diaphragmatic hernia: a meta-analysis of mortality factors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ H Skari \n \t\t\t\t\t\t\t\t """ 1 => """ K Bjornland \n \t\t\t\t\t\t\t\t """ 2 => """ G Haugen \n \t\t\t\t\t\t\t\t """ 3 => """ T Egeland \n \t\t\t\t\t\t\t\t """ 4 => """ R Emblem \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jpsu.2000.8725" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Surg" "fecha" => "2000" "volumen" => "35" "paginaInicial" => "1187" "paginaFinal" => "1197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10945692" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital diaphragmatic hernia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ NP Smith \n \t\t\t\t\t\t\t\t """ 1 => """ EC Jesudason \n \t\t\t\t\t\t\t\t """ 2 => """ PD Losty \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s1526-0542(02)00262-2" "Revista" => array:6 [ "tituloSerie" => "Paediatr Respir Rev" "fecha" => "2002" "volumen" => "3" "paginaInicial" => "339" "paginaFinal" => "348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12457605" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary hypoplasia and congenital diaphragmatic hernia: advances in the pathogenetics and regulation of lung development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ MR Chinoy \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/jsre.2002.6390" "Revista" => array:6 [ "tituloSerie" => "J Surg Res" "fecha" => "2002" "volumen" => "106" "paginaInicial" => "209" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12127828" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malformações torácicas não-cardíacas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ V Bunduki \n \t\t\t\t\t\t\t\t """ 1 => """ R Ruano \n \t\t\t\t\t\t\t\t """ 2 => """ Zugaib \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "editores" => "MZugaib" "titulo" => "Medicina Fetal. Segunda edição" "paginaInicial" => "227" "serieFecha" => "1997" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective study of the outcome for fetuses with diaphragmatic hernia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ MR Harrison \n \t\t\t\t\t\t\t\t """ 1 => """ NS Adzick \n \t\t\t\t\t\t\t\t """ 2 => """ JM Estes \n \t\t\t\t\t\t\t\t """ 3 => """ LJ Howell \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1994" "volumen" => "271" "paginaInicial" => "382" "paginaFinal" => "384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8054005" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Real and apparent mortality from congenital diaphragmatic hernia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ B Jaffray \n \t\t\t\t\t\t\t\t """ 1 => """ GA MacKinlay \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/bjs.1800830125" "Revista" => array:6 [ "tituloSerie" => "Br J Surg" "fecha" => "1996" "volumen" => "83" "paginaInicial" => "79" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8653373" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital diaphragmatic hernia: can prenatal ultrasonography predict outcome?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ M Dommergues \n \t\t\t\t\t\t\t\t """ 1 => """ C Louis-Sylvestre \n \t\t\t\t\t\t\t\t """ 2 => """ L Mandelbrot \n \t\t\t\t\t\t\t\t """ 3 => """ JF Oury \n \t\t\t\t\t\t\t\t """ 4 => """ M Herlicoviez \n \t\t\t\t\t\t\t\t """ 5 => """ G Body \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0002-9378(96)70688-9" "Revista" => array:6 [ "tituloSerie" => "Am J Obstet Gynecol" "fecha" => "1996" "volumen" => "174" "paginaInicial" => "1377" "paginaFinal" => "1381" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8623873" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prediction of outcome by computer-assisted analysis of lung area on the chest radiograph of infants with congenital diaphragmatic hernia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ G Dimitriou \n \t\t\t\t\t\t\t\t """ 1 => """ A Greenough \n \t\t\t\t\t\t\t\t """ 2 => """ M Davenport \n \t\t\t\t\t\t\t\t """ 3 => """ K Nicolaides \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0022-3468(00)90219-7" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Surg" "fecha" => "2000" "volumen" => "35" "paginaInicial" => "489" "paginaFinal" => "493" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10726694" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sonographic predictors of survival in fetal diaphragmatic hernia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ AP Metkus \n \t\t\t\t\t\t\t\t """ 1 => """ RA Filly \n \t\t\t\t\t\t\t\t """ 2 => """ MD Stringer \n \t\t\t\t\t\t\t\t """ 3 => """ MR Harrison \n \t\t\t\t\t\t\t\t """ 4 => """ NS Adzick \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0022-3468(96)90338-3" "Revista" => array:7 [ "tituloSerie" => "J Pediatr Surg" "fecha" => "1996" "volumen" => "31" "numero" => "1" "paginaInicial" => "148" "paginaFinal" => "151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8632269" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective analysis of lung-to-head ratio predicts survival for patients with prenatally diagnosed congenital diaphragmatic hernia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ GS Lipshutz \n \t\t\t\t\t\t\t\t """ 1 => """ CT Albanese \n \t\t\t\t\t\t\t\t """ 2 => """ VA Feldstein \n \t\t\t\t\t\t\t\t """ 3 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\t\t\t\t\t\t\t\t """ 4 => """ TM Crombleholme \n \t\t\t\t\t\t\t\t """ 5 => """ AW Flake \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mob.2000.108895" "Revista" => array:6 [ "tituloSerie" => "Am J Obstet Gynecol" "fecha" => "2000" "volumen" => "183" "paginaInicial" => "1067" "paginaFinal" => "1069" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11084542" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fetal lung volume measurement by magnetic resonance imaging in congenital diaphragmatic hernia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ D Mahieu-Caputo \n \t\t\t\t\t\t\t\t """ 1 => """ P Sonigo \n \t\t\t\t\t\t\t\t """ 2 => """ M Dommergues \n \t\t\t\t\t\t\t\t """ 3 => """ JC Fournet \n \t\t\t\t\t\t\t\t """ 4 => """ JC Thalabard 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ORIGINAL RESEARCH

Rodrigo Ruanoa, Victor Bundukia, Marcos Marques Silvab, Carlos Tadashi Yoshizakia, Uenis Tanurib, João Gilberto Macksoudb, Marcelo Zugaiba

a Department of Obstetrics and Gynecology, Hospital das Clínicas, São Paulo University Medical School.

b Pediatric Surgery Department, Hospital das Clínicas, São Paulo University Medical School.

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    "titulo" => "PRENATAL DIAGNOSIS AND PERINATAL OUTCOME OF 38 CASES WITH CONGENITAL DIAPHRAGMATIC HERNIA&#58; 8-YEAR EXPERIENCE OF A TERTIARY BRAZILIAN CENTER"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Congenital diaphragmatic hernia &#40;CDH&#41; - consisting of a diaphragmatic defect that starts early in the embryological period&#44; with consequent herniation of the abdominal structures into thoracic cavity - occurs in approximately 1 of 2&#44;200 live births&#46;<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#44;2</span></a> Herniated abdominal structures&#44; such as stomach and liver&#44; shift fetal lungs&#44; and cause pulmonary hypoplasia&#44; which is responsible for the high neonatal mortality rate&#46;<a class="elsevierStyleCrossRef" href="#bib3"><span class="elsevierStyleSup">3</span></a> Although the lungs are shifted during fetal life&#44; the placenta maintains respiratory function&#44; allowing correct gas exchange&#46; However&#44; once the umbilical cord is clamped during birth&#44; the hypoplastic lungs cannot perform adequate gas exchange&#44; leading to severe respiratory distress and neonatal death&#46;<a class="elsevierStyleCrossRef" href="#bib4"><span class="elsevierStyleSup">4</span></a></p><p id="para20" class="elsevierStylePara elsevierViewall">Prenatal diagnosis has improved neonatal outcome worldwide through diagnosis of other associated malformations&#44; excluding chromosomal abnormalities&#44; and planning delivery inside a specialized tertiary center&#46;<a class="elsevierStyleCrossRef" href="#bib5"><span class="elsevierStyleSup">5</span></a> Before the onset of prenatal sonographic diagnosis&#44; the mortality rate was almost 100&#37;&#44; and CDH was considered a lethal malformation&#46;<a class="elsevierStyleCrossRef" href="#bib6"><span class="elsevierStyleSup">6</span></a> Nowadays&#44; the mortality rate has been decreasing among neonates with isolated CDH&#44; varying from 40&#37; to 75&#37; in developed countries&#46;<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#44;7</span></a> Nevertheless&#44; in spite of the great advances in prenatal and postnatal diagnosis and management&#44; the mortality rate in neonates with isolated CDH is still high&#46;<a class="elsevierStyleCrossRef" href="#bib8"><span class="elsevierStyleSup">8</span></a></p><p id="para30" class="elsevierStylePara elsevierViewall">Recent research has focused on prenatal predictors of neonatal outcome in isolated CDH cases&#44; such as lung&#47;head ratio<a class="elsevierStyleCrossRefs" href="#bib9"><span class="elsevierStyleSup">9&#44;10</span></a> and fetal lung volume&#44;<a class="elsevierStyleCrossRefs" href="#bib11"><span class="elsevierStyleSup">11&#8211;16</span></a> to differentiate cases with a worse prognosis&#44; in which fetal therapy or termination of pregnancy may be indicated&#44; from those with better prognosis&#44; requiring only specialized postnatal care&#46;<a class="elsevierStyleCrossRefs" href="#bib17"><span class="elsevierStyleSup">17&#8211;19</span></a></p><p id="para40" class="elsevierStylePara elsevierViewall">In spite of the worldwide&#44; published experience&#44; there are no data about perinatal results in cases of prenatally diagnosed CDH in Brazil&#46; Therefore&#44; we reviewed all cases of prenatally diagnosed CDH in a specialized tertiary center&#44; focusing on the frequency of associated structural malformations&#44; chromosomal abnormalities&#44; and the mortality rate&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">PATIENTS AND METHODS</span><p id="para50" class="elsevierStylePara elsevierViewall">We reviewed the prenatal database from January 1995 to December 2003 of the Fetal Medicine Unit of the Department of Obstetrics and Gynecology&#44; S&#227;o Paulo University Medical School&#44; identifying 38 cases of CDH&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">Prenatal characteristics were retrospectively analyzed from the ultrasonographic basic database&#46; The main data analyzed were gestational age at diagnosis&#44; presence of associated structural malformations&#44; fetal karyotyping&#44; side of diaphragmatic defect&#44; mediastinal shift&#44; and liver herniation&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">Perinatal outcome was reviewed by consulting prenatal&#44; neonatal&#44; and pediatric databases&#44; as well as from telephone contacts with parents&#46; Cases were classified according to perinatal outcome including fetal death&#44; early neonatal death &#40;from birth to 7 days of life&#41;&#44; and late neonatal death &#40;after 7 days of life up to 28 days&#41;&#46;</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">RESULTS</span><p id="para80" class="elsevierStylePara elsevierViewall">Among the 38 cases of CDH&#44; 30 &#40;79&#37;&#41; had left CDH&#44; and 8 &#40;21&#37;&#41; had right CDH&#46; Mean gestational age at diagnosis was 29 weeks of gestation &#40;range&#44; 16-37 weeks&#41;&#46; Associated structural malformations were observed in 21 cases &#40;55&#37;&#41;&#44; of which 12 had normal karyotyping &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#41;&#46; Chromosomal abnormality was observed in 9 cases &#40;24&#37;&#41;&#44; including trisomy 18 &#40;n &#61; 4&#41;&#44; trisomy 13 &#40;n &#61; 3&#41;&#44; 46XX&#47;47XXX &#40;n &#61; 1&#41;&#44; and 45X &#40;n &#61; 1&#41;&#46; These two last fetuses had heart malformations in association with congenital diaphragmatic hernia &#40;interventricular defect and aorta coarctation&#44; respectively&#41;&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para90" class="elsevierStylePara elsevierViewall">The overall mortality was 92&#37; &#40;35&#47;38&#41;&#46; All cases with chromosomal abnormalities died before the 7th day of life &#40;mortality of 100&#37;&#41;&#46; Among the 12 cases with associated structural malformation but normal karyotyping&#44; 11 &#40;92&#37;&#41; also died before the 7th day of life &#40;including fetal deaths&#41;&#46; Among all the cases&#44; only 3 infants with CDH survived more than 28 days after surgical repair &#40;including 1 neonate with associated omphalocele&#44; but with a normal karyotype&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><p id="para100" class="elsevierStylePara elsevierViewall">Isolated CDH was observed in 17 cases &#40;45&#37;&#41;&#46; In this group&#44; 15 neonates &#40;88&#37;&#41; died&#46; No fetal death was observed&#44; 2 neonates &#40;12&#37;&#41; survived up to the 28th day of life and 2 neonates &#40;12&#37;&#41; survived after the 28th day of life &#40;<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#41;&#46; Two &#40;12&#37;&#41; neonates underwent surgical repair after satisfactory ventilatory condition and preoperative stabilization between 10 and 22 days of life&#46; Among the neonates with isolated CDH&#44; the diaphragmatic defect was on the left in 12 &#40;71&#37;&#41; and on the right in 5 &#40;29&#37;&#41;&#46; Herniated liver and major mediastinal shift were observed in 7 &#40;41&#37;&#41; and 13 cases &#40;77&#37;&#41;&#44; respectively&#46; All neonates with a herniated liver or right-sided CDH died before the 7th day of life&#46; Among 13 neonates with major mediastinal shift&#44; early death occurred in 10 &#40;77&#37;&#41;&#44; while it occurred in 2 of 4 &#40;50&#37;&#41; without this occurrence &#40;<a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl3"></elsevierMultimedia></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">DISCUSSION</span><p id="para110" class="elsevierStylePara elsevierViewall">The results demonstrate that other structural abnormalities are frequently associated with CDH and that perinatal mortality remains very high&#44; even in neonates with isolated CDH&#46; In this series&#44; because termination of pregnancy &#40;TOP&#41; was not performed&#44; it was possible to evaluate the natural history of CDH in cases with associated structural malformations&#44; chromosomal abnormalities&#44; and even in isolated CDH cases&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">Published reports place the incidence of chromosomal and structural abnormalities in association with CDH at 35&#37; to 50&#37;&#44; including trisomies&#44; most commonly trisomy 18&#46;<a class="elsevierStyleCrossRefs" href="#bib20"><span class="elsevierStyleSup">20&#8211;22</span></a> In this study&#44; 55&#37; of the neonates had associated malformations&#44; and 24&#37; had chromosomal abnormalities&#46; All neonates with chromosomal abnormalities had other associated structural malformations&#46; Among the neonates with abnormal karyotyping&#44; trisomies 18 and 13 were diagnosed in 4 &#40;44&#37;&#41; and 3 &#40;33&#37;&#41; cases&#44; respectively&#46; Cases with abnormal karyotyping usually have the poorest prognosis&#44; with 100&#37; perinatal mortality&#44; typically earlier&#44; because fetal death occurred more often &#40;56&#37;&#41;&#46; In neonates with associated structural malformation but normal karyotype&#44; perinatal mortality was also very high &#40;92&#37;&#41;&#46; This particular group contributed to the very high perinatal mortality observed in our study&#44; mainly to the earlier deaths&#44; ie&#44; fetal demise &#40;42&#37;&#41; and early neonatal deaths &#40;58&#37;&#41;&#46; One infant who had an associated omphalocele and normal karyotype survived&#44; probably because of the mild or less severe herniation of abdominal organs into the fetal thorax&#44; leading to milder compression of mediastinal structures and lungs&#46; Both groups are candidates for medical termination of pregnancy &#40;TOP&#41; in countries where this is allowed by the local law&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">In cases with isolated CDH&#44; perinatal mortality was higher in our series &#40;88&#37;&#41; than reported in the international literature &#40;50&#8211;70&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib23"><span class="elsevierStyleSup">23&#44;24</span></a> This could be explained by many factors&#46; First&#44; in our series there was no TOP&#44; while in the international literature&#44; TOP was performed in about 20&#37; to 30&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a> Second&#44; the main prognostic factor considered was the pulmonary size and&#47;or volume&#44; which is evaluated by the lung-over-head ratio &#40;LOHR&#41;<a class="elsevierStyleCrossRefs" href="#bib9"><span class="elsevierStyleSup">9&#44;10</span></a> and the observed&#47;expected fetal lung volume ratio &#40;o&#47;e-FLV&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib12"><span class="elsevierStyleSup">12&#44;13&#44;16</span></a> Cases with LOHR &#60; 1&#46;0 and o&#47;e-FLV &#60; 0&#46;35 are associated with poorer outcome &#40;approximately 90&#37;&#41;&#46; In many countries&#44; TOP is performed in cases that have a poorer prognosis&#44; with LOHR &#60; 1&#46;0&#44; right defect&#44; and liver herniation&#46; In our series&#44; these parameters were not evaluated&#59; therefore&#44; it is not possible to state whether they are similar or comparable populations&#46;</p><p id="para140" class="elsevierStylePara elsevierViewall">Another possible contributing factor to this difference in perinatal mortality rates is that we included in our study only prenatally diagnosed cases&#44; which are known to have a higher mortality rate than those with only postnatal diagnosis&#46; Skari et al<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a> observed that neonatal mortality is 2 to 4 times higher in prenatally diagnosed than in postnatally diagnosed series&#46; This possibility is supported when the neonatal mortality of 88&#37; in our series is considered in the context of the 40&#37; mortality reported in a previous study published by pediatric surgeons from our hospital&#59; in that study&#44; CDH was diagnosed postnatally&#46;<a class="elsevierStyleCrossRef" href="#bib25"><span class="elsevierStyleSup">25</span></a></p><p id="para150" class="elsevierStylePara elsevierViewall">Additionally&#44; Harrison et al<a class="elsevierStyleCrossRef" href="#bib17"><span class="elsevierStyleSup">17</span></a> recently demonstrated that adequate and specialized neonatal care can improve neonatal survival to about 70&#37; in cases with prenatally diagnosed isolated CDH&#44; even in those cases without prenatal treatment&#46; This finding means that each hospital may have different neonatal mortality rates based on the prenatal selection of population&#44; prenatal interventions&#44; degree of specialization of neonatal care group&#44; and type of postnatal treatment&#46; Consequently&#44; meta-analysis and multicenter studies have important inbuilt bias and must be analyzed carefully&#46; Nevertheless&#44; in our series&#44; right-sided lesion as well as major mediastinal shift and herniated liver were more frequently observed in neonates who died before 7 days of life&#44; and these factors have also been related to a poorer outcome in other studies&#46;<a class="elsevierStyleCrossRefs" href="#bib1"><span class="elsevierStyleSup">1&#44;5&#44;7&#8211;16</span></a></p><p id="para160" class="elsevierStylePara elsevierViewall">By analyzing the natural history of CDH&#44; the present study is important for demonstrating that each hospital may experience different neonatal mortality rates in isolated CDH&#46; It also motivates us to review our neonatal care and our prenatal evaluation of prognosis as well as to consider fetal interventions in selected cases&#46; By improving the neonatal care and prenatal prediction of perinatal outcome in cases with isolated CDH&#44; minimal fetal invasive surgery could be indicated for those cases with a worse prognosis&#44; based on the fact that we cannot offer TOP to those patients&#46;</p></span></span>"
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        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">PURPOSE&#58;</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">To evaluate the perinatal results for neonates with congenital diaphragmatic hernia diagnosed prenatally&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHOD&#58;</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">We reviewed data from 38 cases of congenital diaphragmatic hernia diagnosed prenatally from January 1995 to December 2003 in the Fetal Medicine Unit of the Department of Obstetrics and Gynecology&#44; S&#227;o Paulo University Medical School&#46; The main data analyzed were gestational age at diagnosis&#44; fetal karyotyping&#44; side of diaphragmatic defect&#44; presence of associated structural malformations&#44; hepatic herniation&#44; and severe mediastinal shift&#46; Perinatal outcomes were obtained by reviewing hospital documents or by directly calling the patients&#8217; immediate relatives&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">Mean gestational age at diagnosis was 29 weeks &#40;range&#44; 16-37 weeks&#41;&#46; Thirty &#40;79&#37;&#41; cases had a left diaphragmatic defect and 8 &#40;21&#37;&#41; had a right lesion&#46; Associated structural malformations were observed in 21 &#40;55&#37;&#41; cases&#44; in which 12 fetuses had a normal karyotype and 9 had chromosomal abnormalities&#46; Isolated congenital diaphragmatic hernia was confirmed in 17 &#40;45&#37;&#41; cases&#46; The overall perinatal mortality rate was 92&#37;&#46; Rates of fetal deaths&#44; early neonatal deaths&#44; late neonatal deaths&#44; and survival were 42&#37;&#44; 50&#37;&#44; 0&#37;&#44; and 8&#37;&#44; respectively&#44; in cases with associated structural malformations but normal karyotyping&#59; 56&#37;&#44; 44&#37;&#44; 0&#37;&#44; and 0&#37; for cases with chromosomal abnormalities&#59; and&#44; 0&#37;&#44; 76&#37;&#44; 12&#37;&#44; and 12&#37; in cases with isolated congenital diaphragmatic hernia&#46; The neonatal mortality rate was 89&#37; in cases with isolated congenital diaphragmatic hernia&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSION&#58;</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">Perinatal mortality was very high in prenatally diagnosed cases of congenital diaphragmatic hernia&#46; Earlier perinatal deaths are associated with the presence of other structural defects or chromosomal abnormalities&#46; In cases of isolated congenital diaphragmatic hernia&#44; mortality is related to the presence of herniated liver&#44; right-sided lesion&#44; and major mediastinal shift&#46;</p></span>"
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        "resumen" => "<span id="ceabs50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">OBJETIVO&#58;</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">Avaliar os resultados neonatais dos casos de h&#233;rnia diafragm&#225;tica cong&#234;nita com diagn&#243;stico pr&#233;-natal&#46;</p></span> <span id="ceabs60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">PACIENTES E M&#201;TODOS&#58;</span><p id="spara110" class="elsevierStyleSimplePara elsevierViewall">De janeiro de 1995 a dezembro de 2003 foram revisados os dados de 38 fetos com h&#233;rnia diafragm&#225;tica diagnosticada durante o per&#237;odo pr&#233;-natal na Unidade de Medicina Fetal do Departamento de Obstetr&#237;cia e Ginecologia da Faculdade de Medicina da Universidade de S&#227;o Paulo&#46; Os dados pr&#233;-natais analisados foram&#58; idade gestacional no diagn&#243;stico&#44; cari&#243;tipo fetal&#44; lado da les&#227;o&#44; presen&#231;a de malforma&#231;&#227;o estrutural associada&#44; hernia&#231;&#227;o hep&#225;tica e desvio garve de mediastino&#46; Os dados perinatais foram avaliados consultando os prontu&#225;rios m&#233;dicos ou por contato telef&#244;nico&#46;</p></span> <span id="ceabs70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">RESULTADOS&#58;</span><p id="spara120" class="elsevierStyleSimplePara elsevierViewall">A idade gestacional m&#233;dia no diagn&#243;stico foi de 29 semanas &#40;16-37&#41;&#46; Trinta &#40;79&#37;&#41; casos apresentavam les&#227;o &#224; esquerda e 8 &#40;21&#37;&#41; &#224; direita&#46; Malforma&#231;&#245;es estruturais associadas foram observadas em 21 &#40;55&#37;&#41; casos&#44; dos quais 12 fetos apresentaram cari&#243;tipo normal&#44; enquanto 9 exibiram anomalias cromoss&#244;micas&#46; H&#233;rnia diafragm&#225;tica isolada foi identificada em 17 &#40;457&#37;&#41; casos&#46; A taxa de mortalidade geral foi de 92&#37;&#46; A taxa de &#243;bito fetal&#44; neomorto precoce&#44; neomorto tardio e sobrevivente ap&#243;s 28 dias de vida foram respectivamente&#58; &#40;i&#41; para o grupo com malforma&#231;&#227;o estrutural associada e cari&#243;tipo normal&#44; de 42&#37;&#44; 50&#37;&#44; 0&#37; e 8&#37;&#59; &#40;ii&#41; para os casos com cromos-somopatia&#44; de 56&#37;&#44; 44&#37;&#44; 0&#37; e 0&#37;&#59; &#40;iii&#41; para os casos com les&#245;es isoladas de 0&#37;&#44; 76&#37;&#44; 12&#37; e 12&#37;&#46; Na h&#233;rnia diafragm&#225;tica cong&#234;nita isolada&#44; a mortalidade neonatal foi de 88&#37;&#46;</p></span> <span id="ceabs80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">CONCLUS&#195;O&#58;</span><p id="spara130" class="elsevierStyleSimplePara elsevierViewall">Em nosso servi&#231;o&#44; a mortalidade perinatal nos casos de h&#233;rnia diafragm&#225;tica diagnosticada durante o pr&#233;-natal &#233; muito alta&#46; &#211;bitos neonatais precoces est&#227;o associados com presen&#231;a de outros defeitos estruturais ou anomalias cromoss&#244;micas&#46; Nos casos de HDC isolada&#44; a mortalidade est&#225; relacionada &#224; presen&#231;a de f&#237;gado herniado&#44; lado direito da les&#227;o e desvio grave de mediastino&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "ceabs50"
            "titulo" => "OBJETIVO&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs60"
            "titulo" => "PACIENTES E M&#201;TODOS&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs70"
            "titulo" => "RESULTADOS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs80"
            "titulo" => "CONCLUS&#195;O&#58;"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "tbl1"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">CASE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">STRUCTURAL MALFORMATION&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">KARYOTYPING&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Onphalocele&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Renal dysplasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Spina bifida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Occipital ecephalocele&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Heart defect &#40;Fallot&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dandy Walker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Type III adenomatoid malformation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dandy Walker and heart defect&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Occipital encephalocele and heart defect&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hydrocephaly and renal agenesy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Spine bifida and left kidney agenesy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Renal dysplasia and heart defect&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 XY&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Description of the associated structural malformations with normal karyotype</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl2"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">CDH&#58; congenital diaphragmatic hernia&#59; MF&#58; structural malformation&#59; early NND&#58; neonatal death before 7 days of life&#59; late NND&#58; neonatal deaths between 7 and 28 days of life&#59; Survival&#58; cases that survived after 28 days of life</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Fetal deathn &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">early NNDn &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">late NNDn &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Survivaln &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Totaln &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Isolated CDH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;76&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;11&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;11&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Associated MF with normal karyotype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;41&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;50&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;8&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chromosomal abnormalities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;55&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;44&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
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          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Perinatal outcome in cases with congenital diaphragmatic hernia according to associated structural and chromosomal abnormalities</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl3"
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        "mostrarFloat" => true
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        "tabla" => array:2 [
          "leyenda" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">CDH&#58; congenital diaphragmatic hernia&#59; early NND&#58; neonatal death before 7 days of life&#59; late NND&#58; neonatal deaths between 7 and 28 days of life&#59; Survival&#58; infants that survived after 28 days of life&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">early NND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">late NND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">survival&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Side of CDH</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>left CDH&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>rigth CDH&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Herniated liver</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>present&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>absent&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Major mediastinal shift</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>present&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>absent&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Outcome for neonates with isolated CDH&#44; by prenatal ultrasonographic findings</p>"
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      ]
    ]
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      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital diaphragmatic hernia&#58; a meta-analysis of mortality factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              H Skari \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              K Bjornland \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              G Haugen \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              T Egeland \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Emblem \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jpsu.2000.8725"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Surg"
                        "fecha" => "2000"
                        "volumen" => "35"
                        "paginaInicial" => "1187"
                        "paginaFinal" => "1197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10945692"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital diaphragmatic hernia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              NP Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              EC Jesudason \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              PD Losty \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s1526-0542(02)00262-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Paediatr Respir Rev"
                        "fecha" => "2002"
                        "volumen" => "3"
                        "paginaInicial" => "339"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12457605"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary hypoplasia and congenital diaphragmatic hernia&#58; advances in the pathogenetics and regulation of lung development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => """
                              MR Chinoy \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1006/jsre.2002.6390"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Surg Res"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "209"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12127828"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
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            3 => array:3 [
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              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malforma&#231;&#245;es tor&#225;cicas n&#227;o-card&#237;acas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              V Bunduki \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              R Ruano \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              Zugaib \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "editores" => "MZugaib"
                        "titulo" => "Medicina Fetal&#46; Segunda edi&#231;&#227;o"
                        "paginaInicial" => "227"
                        "serieFecha" => "1997"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A prospective study of the outcome for fetuses with diaphragmatic hernia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              MR Harrison \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              NS Adzick \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JM Estes \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
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Article information

ISSN: 18075932
Original language: English

DOI:10.1590/S1807-59322006000300003

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Year/Month	Html	Pdf	Total

2024 November	4	2	6
2024 October	30	30	60
2024 September	34	29	63
2024 August	32	25	57
2024 July	49	21	70
2024 June	50	22	72
2024 May	67	12	79
2024 April	47	15	62
2024 March	29	9	38
2024 February	32	8	40
2024 January	15	10	25
2023 December	16	17	33
2023 November	25	16	41
2023 October	35	20	55
2023 September	23	23	46
2023 August	9	6	15
2023 July	11	19	30
2023 June	14	13	27
2023 May	38	4	42
2023 April	31	4	35
2023 March	22	1	23
2023 February	20	2	22
2023 January	6	2	8
2022 December	17	0	17

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