LETTER TO THE EDITORS
PEMPHIGUS VEGETANS ASSOCIATED WITH VERRUCOUS LESIONS - EXPANDING A PHENOTYPE
Hiram Larangeira de Almeida Jr., Maria Gertrudes Pereira Neugebauer, Isabelle Maffei Guarenti, Valéria Aoki
Federal University of Pelotas - Pelotas/RS, Brazil.
Catholic University of Pelotas - Pelotas/RS, Brazil.
São Paulo University Medical School - São Paulo/SP, Brazil.
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"tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "277" "paginaFinal" => "278" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1167 "Ancho" => 993 "Tamanyo" => 82617 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Endoscopic image of the vascular lesion on the major duodenal papilla with complete involvement of the ostium (head arrow)</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Everson L.A. Artifon, Paulo Sakai, Gustavo O. Luz, Carlos K. Furuya, Adriana V. 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"apellidos" => "de Souza" ] 6 => array:2 [ "nombre" => "Shinichi" "apellidos" => "Ishioka" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222032707?idApp=UINPBA00004N" "url" => "/18075932/0000006100000003/v1_202212060845/S1807593222032707/v1_202212060845/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">LETTER TO THE EDITORS</span>" "titulo" => "PEMPHIGUS VEGETANS ASSOCIATED WITH VERRUCOUS LESIONS - EXPANDING A PHENOTYPE" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "279" "paginaFinal" => "282" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Hiram Larangeira de Almeida, Maria Gertrudes Pereira Neugebauer, Isabelle Maffei Guarenti, Valéria Aoki" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Hiram Larangeira" "apellidos" => "de Almeida" "sufijo" => "Jr." "email" => array:1 [ 0 => "hiramalmeidajr@hotmail.com" ] ] 1 => array:2 [ "nombre" => "Maria Gertrudes Pereira" "apellidos" => "Neugebauer" ] 2 => array:2 [ "nombre" => "Isabelle Maffei" "apellidos" => "Guarenti" ] 3 => array:2 [ "nombre" => "Valéria" "apellidos" => "Aoki" ] ] "afiliaciones" => array:3 [ 0 => array:2 [ "entidad" => "Federal University of Pelotas - Pelotas/RS, Brazil." "identificador" => "aff1" ] 1 => array:2 [ "entidad" => "Catholic University of Pelotas - Pelotas/RS, Brazil." "identificador" => "aff2" ] 2 => array:2 [ "entidad" => "São Paulo University Medical School - São Paulo/SP, Brazil." "identificador" => "aff3" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig4" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 930 "Ancho" => 1686 "Tamanyo" => 397344 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Light microscopy a. suprabasal cleft in the oral mucosa. b. suprabasal cleft and acantholytic cells (arrow) from a vegetant lesion. c. epithelial hyperplasia with neutrophil abcess from a verrucous acral lesion</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para10" class="elsevierStylePara elsevierViewall">Pemphigus vegetans (PV), a variant of pemphigus vulgaris, is the rarest form of pemphigus, accounting for 2% of patients with this class of disease in Sicily,<a class="elsevierStyleCrossRef" href="#bib1"><span class="elsevierStyleSup">1</span></a> 3.3% in Mali,<a class="elsevierStyleCrossRef" href="#bib2"><span class="elsevierStyleSup">2</span></a> and 5.7% in Tunisia.<a class="elsevierStyleCrossRef" href="#bib3"><span class="elsevierStyleSup">3</span></a> It is an autoimmune disease, characterized by flaccid bullae or pustules that erode to form hypertrophic papillated plaques involving predominantly skin folds, scalp, face, and mucous membranes.<a class="elsevierStyleCrossRef" href="#bib4"><span class="elsevierStyleSup">4</span></a> Nail involvement is seldom described. We report a case of pemphigus vegetans with typical skin fold involvement, nail dystrophy with verrucous paronychia, and acral verrucous lesions.</p><p id="para20" class="elsevierStylePara elsevierViewall">A 65-year-old white woman, in treatment for diabetes mellitus and hyperthyroidism for years, complained of flare-ups of erosions on the oral mucosa, explained by the use of dentures. Biopsy of the oral mucosa was performed and evaluated as inconclusive. After some weeks, additional erosions in the genital mucosa and perianal region were observed. Since the probable initial diagnosis was of Stevens-Johnson’s syndrome, she was placed on steroid therapy, antibiotics, and volume and electrolytic replacement, which controlled her condition. After reduction and withdrawal of the steroids, she presented a worsening of her skin disease with vegetations in inframammary, axillary, and inguinal folds (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). The patient’s vermillion of the lips had a verrucous appearance (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>). She also had hyperkeratotic plaques on the borders of both feet (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>), as well as verrucous paronychia of the 20 nails (<a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>) with pachyonychia and onychorrhexis.</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><elsevierMultimedia ident="fig2"></elsevierMultimedia><elsevierMultimedia ident="fig3"></elsevierMultimedia><p id="para30" class="elsevierStylePara elsevierViewall">Laboratory tests were normal. Some flaccid blisters or blister traces could be also seen (<a class="elsevierStyleCrossRefs" href="#fig1">Figures 1 and 3</a>).</p><p id="para40" class="elsevierStylePara elsevierViewall">Histology of a vegetating lesion from a skin fold revealed a suprabasal cleft with acantholytic cells; from a verrucous acral lesion, epithelial hyperplasia with microabscesses composed of eosinophils, neutrophils, and some acantholytic cells (<a class="elsevierStyleCrossRef" href="#fig4">Figure 4</a>). The first histologic examination of the oral lesion was reviewed, and a suprabasal cleft was found (<a class="elsevierStyleCrossRef" href="#fig4">Figure 4</a>).</p><elsevierMultimedia ident="fig4"></elsevierMultimedia><p id="para50" class="elsevierStylePara elsevierViewall">Indirect immunofluorescence was performed as follows: Sera samples in serial dilutions were incubated for 30 minutes with tissue cryosections on albuminized slides. Two 20-minute-washes with trisma base solution, calcium-enhanced, pH 7.5 (TBS-Ca<span class="elsevierStyleSup">++</span>) were performed, followed by incubation for 30 minutes with conjugates (fluorescein-antihuman immunoglobulins G, A, M, and C3 fractions, SIGMA, USA), at a 1:20 dilution in TBS-Ca<span class="elsevierStyleSup">++</span>. Two final washes with TBS-Ca<span class="elsevierStyleSup">++</span> were performed, and an epiluminescence microscope HBO50W (CB12 filter) (Zeiss, Germany) was used for the reading. Indirect immunofluorescence showed intercellular deposition of IgG4 and IgG1 antibodies at a titer of 1:2560 and 1:20, respectively.</p><p id="para60" class="elsevierStylePara elsevierViewall">Systemic corticosteroid (prednisone 80 mg/day) therapy was reintroduced associated with dapsone (100 mg/day), with a good response.</p><p id="para70" class="elsevierStylePara elsevierViewall">Historically, cases of pemphigus vegetans have been divided into 2 clinical subclasses: the Hallopeau type and the Neumann type. The first starts with circumscribed pustules and has a relatively benign course; in contrast, the Neumann type has vesicles and bullae as primary lesions, is usually more frequently seen and develops extensive lesions that are often refractory to therapy.<a class="elsevierStyleCrossRef" href="#bib5"><span class="elsevierStyleSup">5</span></a> The diagnosis of pemphigus vegetans is based on clinical manifestations and confirmed by histology. Involvement of the vermillion border of the lips is the clinical hallmark of oral involvement. Proliferative growth begins at the sites of pustules or bullae that erode, and it gradually becomes vegetative and hypertrophic.<a class="elsevierStyleCrossRef" href="#bib6"><span class="elsevierStyleSup">6</span></a> These verrucous lesions can be clinically similar to common warts<a class="elsevierStyleCrossRef" href="#bib7"><span class="elsevierStyleSup">7</span></a> or they may evolve into vegetating masses up to several centimeters in diameter, with fresh vesicles or pustules at the periphery of the lesion.<a class="elsevierStyleCrossRef" href="#bib6"><span class="elsevierStyleSup">6</span></a> Both circumstances were present this case. Nail involvement in pemphigus is rare; it has been described in pemphigus vulgaris in a variety of manifestations: chronic paronychia, onychomadesis, onycholysis, Beau’s lines, trachyonychia, subunguial hemorrhage, nail dystrophy, and vegetative lesions over paronychia.<a class="elsevierStyleCrossRefs" href="#bib7"><span class="elsevierStyleSup">7,8</span></a></p><p id="para80" class="elsevierStylePara elsevierViewall">Histological findings, such as epithelial hyperplasia, suprabasal cleft and acantholytic cells, as well as microabscesses composed of eosinophils and neutrophils, are the main characteristics, as seen in this patient.<a class="elsevierStyleCrossRefs" href="#bib6"><span class="elsevierStyleSup">6,9</span></a></p><p id="para90" class="elsevierStylePara elsevierViewall">Immunofluorescence techniques have proved to be important in the differential diagnosis of bullous disorders and the pemphigus group has the classical intercellular pattern.</p><p id="para100" class="elsevierStylePara elsevierViewall">The most important differential diagnosis is the Pyodermatitis-pyostomatitis vegetans, which has similar clinical and histological manifestations, but has negative immunofluorescence results.<a class="elsevierStyleCrossRef" href="#bib10"><span class="elsevierStyleSup">10</span></a></p><p id="para110" class="elsevierStylePara elsevierViewall">Because of the mucosal involvement, the first clinical diagnosis made was of Stevens-Johnson’s syndrome, a severe expression of erythema multiforme that involves the skin and the mucous membranes, which is an important differential diagnosis of bullous disorders. The association of PV with lung neoplasia has already been reported.<a class="elsevierStyleCrossRef" href="#bib11"><span class="elsevierStyleSup">11</span></a></p><p id="para120" class="elsevierStylePara elsevierViewall">Treatment of PV often involves the use of immunosuppressive agents, and steroids have been the mainstay of clinical management. However, oral administration of corticosteroids alone does not always induce disease remission.<a class="elsevierStyleCrossRef" href="#bib12"><span class="elsevierStyleSup">12</span></a> In the literature reviewed, the association of systemic steroid therapy with azathioprine, dapsone, cyclophosphamide, and cyclosporine as effective treatment has been described. When it comes to persistent, verrucous vegetations, the combination of corticosteroid and etretinate resulted in healing of the lesions.<a class="elsevierStyleCrossRef" href="#bib12"><span class="elsevierStyleSup">12</span></a> Moreover, the association of methotrexate, dicloxacillin, oral steroids, and periodic intralesional corticosteroid injections were effective in a relatively resistant scalp disease.<a class="elsevierStyleCrossRef" href="#bib13"><span class="elsevierStyleSup">13</span></a></p><p id="para130" class="elsevierStylePara elsevierViewall">The vermillion and nail involvement, as well as the verrucous, hyperkeratotic acral plaques seen in this patient were also described in other cases of pemphigus vulgaris\vegetans,<a class="elsevierStyleCrossRefs" href="#bib6"><span class="elsevierStyleSup">6–8</span></a> and these should be considered, together with the classical vegetant lesions in the skin folds, characteristic of the verrucous variant of this condition.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 990 "Ancho" => 1433 "Tamanyo" => 217762 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">a. vegetating plaques on the inframammary fold. b.similar lesions in the axilary fold with two small blisters (arrows)</p>" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 664 "Ancho" => 2045 "Tamanyo" => 204951 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">a. verrucous plaque on the right foot, note the pustule on the periphery (arrow) b. verrucous aspect of the lips</p>" ] ] 2 => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 770 "Ancho" => 1488 "Tamanyo" => 214356 ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">a. verrucous paronychia with dystrophic finger nail b. similar aspect of the halux. Note the rest of some flacid bullae (arrows)</p>" ] ] 3 => array:7 [ "identificador" => "fig4" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 930 "Ancho" => 1686 "Tamanyo" => 397344 ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Light microscopy a. suprabasal cleft in the oral mucosa. b. suprabasal cleft and acantholytic cells (arrow) from a vegetant lesion. c. epithelial hyperplasia with neutrophil abcess from a verrucous acral lesion</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiologic analysis and clinical course of 84 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] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/s0041-87812002000500007" "Revista" => array:6 [ "tituloSerie" => "Rev Hosp Clín Fac Med S Paulo" "fecha" => "2002" "volumen" => "57" "paginaInicial" => "229" "paginaFinal" => "234" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12436180" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pemphigus vegetans. A historical perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ T Jansen \n \t\t\t\t\t\t\t\t """ 1 => """ G Messer \n \t\t\t\t\t\t\t\t """ 2 => """ M Meurer \n \t\t\t\t\t\t\t\t """ 3 => """ G Plewig \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s001050000088" "Revista" => array:6 [ "tituloSerie" => "Hautarzt" "fecha" => "2001" "volumen" => "52" "paginaInicial" => "504" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11428079" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pyodermatitis-pyostomatitis vegetans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ M Mehravaran \n \t\t\t\t\t\t\t\t """ 1 => """ L Kemény \n \t\t\t\t\t\t\t\t """ 2 => """ S Husz \n \t\t\t\t\t\t\t\t """ 3 => """ I Korom \n \t\t\t\t\t\t\t\t """ 4 => """ M Kiss \n \t\t\t\t\t\t\t\t """ 5 => """ A Dobozy \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1365-2133.1997.18181914.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1997" "volumen" => "137" "paginaInicial" => "266" "paginaFinal" => "269" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9292079" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pemphigus vegetans in a patient with lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ AB Serwin \n \t\t\t\t\t\t\t\t """ 1 => """ E Bokiniec \n \t\t\t\t\t\t\t\t """ 2 => """ B Chodynicka \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatology Online Journal" "fecha" => "2005" "volumen" => "11" "paginaInicial" => "13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16409909" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of pemphigus vegetans by addition of etretinate to systemic steroids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ M Ichimiya \n \t\t\t\t\t\t\t\t """ 1 => """ K Yamamoto \n \t\t\t\t\t\t\t\t """ 2 => """ M Muto \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Experim Derm" "fecha" => "1998" "volumen" => "23" "paginaInicial" => "178" "paginaFinal" => "180" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment-resistant pemphigus vegetans of the scalp" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ SC Rackett \n \t\t\t\t\t\t\t\t """ 1 => """ MJ Rothe \n \t\t\t\t\t\t\t\t """ 2 => """ DM Hoss \n \t\t\t\t\t\t\t\t """ 3 => """ CM Grin-Jorgensen \n \t\t\t\t\t\t\t\t """ 4 => """ JM Grant-Kels \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4362.1995.tb04426.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "1995" "volumen" => "34" "paginaInicial" => "865" "paginaFinal" => "866" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8647669" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006100000003/v1_202212060845/S1807593222032719/v1_202212060845/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006100000003/v1_202212060845/S1807593222032719/v1_202212060845/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222032719?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 5 | 14 |
| 2024 October | 65 | 31 | 96 |
| 2024 September | 61 | 30 | 91 |
| 2024 August | 76 | 40 | 116 |
| 2024 July | 55 | 45 | 100 |
| 2024 June | 33 | 26 | 59 |
| 2024 May | 45 | 16 | 61 |
| 2024 April | 43 | 14 | 57 |
| 2024 March | 50 | 12 | 62 |
| 2024 February | 73 | 13 | 86 |
| 2024 January | 80 | 14 | 94 |
| 2023 December | 84 | 25 | 109 |
| 2023 November | 79 | 27 | 106 |
| 2023 October | 98 | 32 | 130 |
| 2023 September | 81 | 42 | 123 |
| 2023 August | 55 | 13 | 68 |
| 2023 July | 56 | 27 | 83 |
| 2023 June | 42 | 15 | 57 |
| 2023 May | 38 | 8 | 46 |
| 2023 April | 10 | 6 | 16 |
| 2023 March | 9 | 8 | 17 |
| 2023 February | 1 | 4 | 5 |
| 2023 January | 0 | 1 | 1 |
| 2022 December | 1 | 1 | 2 |
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