was read the article
array:22 [ "pii" => "S1807593224000140" "issn" => "18075932" "doi" => "10.1016/j.clinsp.2024.100337" "estado" => "S250" "fechaPublicacion" => "2024-01-01" "aid" => "100337" "copyright" => "HCFMUSP" "copyrightAnyo" => "2024" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S180759322400005X" "issn" => "18075932" "doi" => "10.1016/j.clinsp.2024.100328" "estado" => "S250" "fechaPublicacion" => "2024-01-01" "aid" => "100328" "copyright" => "HCFMUSP" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Cross-cultural adaptation of the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH) to Brazilian Portuguese and its psychometric properties—A multicenter cross-sectional study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "en" ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2378 "Ancho" => 3000 "Tamanyo" => 355573 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Flowchart of cultural adaptation and validation processes (OEV, Original English Version; OSV, Original Spanish Version; PV1-6, Portuguese versions 1 to 6; CPV1-2, Consensus Portuguese versions 1 and 2; FCPV, Final Consensus Portuguese Version; FPV, Final Portuguese Version).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pablo Eduardo Pereira Dutra, Laiana Azevedo Quagliato, Filipe Terra Curupaná, Letícia Zangirolami Peres, Victoria Luiza Pacini, Claudia Regina Menezes da Silva, Juliana Seixas Garcia, Beatriz Campillo Zaragoza, Antonio Egidio Nardi" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Pablo Eduardo" "apellidos" => "Pereira Dutra" ] 1 => array:2 [ "nombre" => "Laiana Azevedo" "apellidos" => "Quagliato" ] 2 => array:2 [ "nombre" => "Filipe Terra" "apellidos" => "Curupaná" ] 3 => array:2 [ "nombre" => "Letícia Zangirolami" "apellidos" => "Peres" ] 4 => array:2 [ "nombre" => "Victoria Luiza" "apellidos" => "Pacini" ] 5 => array:2 [ "nombre" => "Claudia Regina Menezes" "apellidos" => "da Silva" ] 6 => array:2 [ "nombre" => "Juliana Seixas" "apellidos" => "Garcia" ] 7 => array:2 [ "nombre" => "Beatriz Campillo" "apellidos" => "Zaragoza" ] 8 => array:2 [ "nombre" => "Antonio Egidio" "apellidos" => "Nardi" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><p id="spara015" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001"><span class="elsevierStyleLabel">•</span><p id="para0001" class="elsevierStylePara elsevierViewall">Despite their importance, dignity and respect are woefully undefined, and often cast aside, which is reflected by the scarcity of in-depth studies.</p></li><li class="elsevierStyleListItem" id="celistitem0002"><span class="elsevierStyleLabel">•</span><p id="para0002" class="elsevierStylePara elsevierViewall">Brazilian patients feel respected, but when it comes to consideration and integrity, it is nothing short of heartbreaking.</p></li><li class="elsevierStyleListItem" id="celistitem0003"><span class="elsevierStyleLabel">•</span><p id="para0003" class="elsevierStylePara elsevierViewall">Brazilian health professionals do not ask their patients whom they would like to share information with. And this demands our utmost attention.</p></li><li class="elsevierStyleListItem" id="celistitem0004"><span class="elsevierStyleLabel">•</span><p id="para0004" class="elsevierStylePara elsevierViewall">A sting of disrespect and affronts to our dignity seldom escape our notice.</p></li><li class="elsevierStyleListItem" id="celistitem0005"><span class="elsevierStyleLabel">•</span><p id="para0005" class="elsevierStylePara elsevierViewall">The Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient sheds light on this aspect of human interaction.</p></li></ul></p></span>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S180759322400005X?idApp=UINPBA00004N" "url" => "/18075932/000000790000000C/v123_202411010523/S180759322400005X/v123_202411010523/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S1807593224000152" "issn" => "18075932" "doi" => "10.1016/j.clinsp.2024.100338" "estado" => "S250" "fechaPublicacion" => "2024-01-01" "aid" => "100338" "copyright" => "HCFMUSP" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Prolonged survival after thoracic metastasectomy in patients with nonseminomatous testicular cancer" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "en" ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 658 "Ancho" => 1667 "Tamanyo" => 79693 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Primary tumors are represented on the left and metastasis in the right. (<span class="elsevierStyleItalic">n</span> = 37 patients). Color code: Choriocarcinoma ‒ light blue; Yolk sac ‒ green; Embryonal carcinoma ‒ yellow; Teratoma ‒ red; Somatic malignancy ‒ pink; Necrosis ‒ dark blue.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jaqueline Schaparini Fonini, Pedro Henrique Xavier Nabuco de Araujo, Paula Duarte D'Ambrosio, Juliana Vieira de Oliveira Salerno, Pedro Prosperi Desenzi Ciaralo, Ricardo Mingarini Terra, Paulo Manuel Pêgo-Fernandes" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Jaqueline Schaparini" "apellidos" => "Fonini" ] 1 => array:2 [ "nombre" => "Pedro Henrique Xavier Nabuco" "apellidos" => "de Araujo" ] 2 => array:2 [ "nombre" => "Paula Duarte" "apellidos" => "D'Ambrosio" ] 3 => array:2 [ "nombre" => "Juliana Vieira de Oliveira" "apellidos" => "Salerno" ] 4 => array:2 [ "nombre" => "Pedro Prosperi Desenzi" "apellidos" => "Ciaralo" ] 5 => array:2 [ "nombre" => "Ricardo Mingarini" "apellidos" => "Terra" ] 6 => array:2 [ "nombre" => "Paulo Manuel" "apellidos" => "Pêgo-Fernandes" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><p id="spara007" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001"><span class="elsevierStyleLabel">•</span><p id="para0001" class="elsevierStylePara elsevierViewall">Few studies have examined outcomes after intrathoracic metastasectomy for nonseminomatous testicular germ cell tumors.</p></li><li class="elsevierStyleListItem" id="celistitem0002"><span class="elsevierStyleLabel">•</span><p id="para0002" class="elsevierStylePara elsevierViewall">Integration of local and systemic therapies yields favorable outcomes with low morbidity and mortality.</p></li><li class="elsevierStyleListItem" id="celistitem0003"><span class="elsevierStyleLabel">•</span><p id="para0003" class="elsevierStylePara elsevierViewall">Surgical management should be considered after chemotherapy, as histology prediction for metastatic lesions remains challenging.</p></li><li class="elsevierStyleListItem" id="celistitem0004"><span class="elsevierStyleLabel">•</span><p id="para0004" class="elsevierStylePara elsevierViewall">This study highlights the importance of aggressive surgical approaches in improving long-term survival in young patients with testicular NSGCT.</p></li></ul></p></span>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593224000152?idApp=UINPBA00004N" "url" => "/18075932/000000790000000C/v123_202411010523/S1807593224000152/v123_202411010523/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Effect of 3D laparoscopy versus traditional laparotomy on serum tumor markers and coagulation function in patients with early-stage endometrial cancer" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Hailong Chen, Dechang Xu, Ying Yu, Jing Huang, Qian Zhou, Qi Wang" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Hailong" "apellidos" => "Chen" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn1" ] ] ] 1 => array:3 [ "nombre" => "Dechang" "apellidos" => "Xu" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn1" ] ] ] 2 => array:3 [ "nombre" => "Ying" "apellidos" => "Yu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] ] ] 3 => array:3 [ "nombre" => "Jing" "apellidos" => "Huang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] ] ] 4 => array:3 [ "nombre" => "Qian" "apellidos" => "Zhou" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] ] ] 5 => array:4 [ "nombre" => "Qi" "apellidos" => "Wang" "email" => array:1 [ 0 => "wangqi138797@163.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0001" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Gynecologic Oncology, Ganzhou Cancer Hospital, Ganzhou, Jiangxi, China" "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Ganzhou Cancer Hospital, Ganzhou, Jiangxi, China" "etiqueta" => "b" "identificador" => "aff0002" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0001" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 3003 "Ancho" => 3167 "Tamanyo" => 631644 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0008" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara005" class="elsevierStyleSimplePara elsevierViewall">Assessment of inflammatory response indicators post 3D laparoscopic and traditional laparotomy in early endometrial cancer patients. Three months post-surgery, <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 5</a> reveals: (A) A marked increase in residual urine volume in both groups. However, this increase was less pronounced in the 3D laparoscopic group. (B) The maximum urinary flow rate and (C) The average urinary flow rate were discernibly reduced, yet these reductions were less substantial in the 3D laparoscopic group. (D) Conversely, the maximal pressure exerted by the forced urethral muscle was elevated, with the 3D laparoscopic group exhibiting a greater increase than the laparotomy group. Note: Compared with the preoperative period, <span class="elsevierStyleItalic">p</span> < 0.001; compared with the laparotomy group, <span class="elsevierStyleSup">###</span><span class="elsevierStyleItalic">p</span> < 0.001.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0008">Introduction</span><p id="para0009" class="elsevierStylePara elsevierViewall">Endometrial Cancer (EC) ranks as the third most prevalent gynecological malignancy in China, surpassed only by cervical and ovarian cancers. Alarmingly, the incidence of EC has surged in recent years, with a notable shift toward younger age groups, posing severe threats to patients' well-being and quality of life.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> Patients in the early stages of EC typically exhibit symptoms such as irregular vaginal discharge and bleeding. Due to heightened health awareness and advancements in medical technology, the majority of EC cases are now diagnosed early.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Presently, surgical intervention is the primary treatment for early-stage EC. Most patients undergoing surgery experience therapeutic benefits, boasting a survival rate exceeding 80 % over a five-year span, and a minimal mortality rate.<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> Historically, traditional laparotomy was the go-to approach for early EC, effectively removing the lesions. However, this method was associated with greater trauma, increased complications, and prolonged recovery.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> Thus, refining treatment strategies for early EC has become a pivotal research focus in leading medical institutions.</p><p id="para0010" class="elsevierStylePara elsevierViewall">In light of ongoing medical advancements, laparoscopic surgery has gained traction for the clinical management of early-stage EC. This method is lauded for its minimal invasiveness, reduced intraoperative bleeding, and fewer complications, subsequently leading to a marked reduction in hospital stays.<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> Yet, conventional laparoscopic procedures primarily offer two-dimensional visualizations, devoid of spatial depth and orientation. This limitation impedes the accurate portrayal of innate anatomical structures, compelling surgeons to rely heavily on their clinical expertise to decipher anatomical nuances, thereby amplifying operational challenges.<a class="elsevierStyleCrossRef" href="#bib0008"><span class="elsevierStyleSup">8</span></a> In contrast, Three-Dimensional (3D) laparoscopic technology furnishes surgeons with accurate spatial and stereoscopic perspectives, engrossing them in a genuine three-dimensional operative environment. This immersion simplifies the procedure and enhances surgical outcomes.<a class="elsevierStyleCrossRef" href="#bib0009"><span class="elsevierStyleSup">9</span></a> Notwithstanding its potential, there are scant clinical evaluations of 3D laparoscopic techniques in treating early-stage EC. To bridge this knowledge gap, the present study juxtaposed the impacts of 3D laparoscopy against traditional laparotomy, focusing on serum tumor markers and coagulation function in early-stage EC patients.</p></span><span id="sec0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0009">Materials and methods</span><span id="sec0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0010">Clinical data</span><p id="para0011" class="elsevierStylePara elsevierViewall">The authors conducted a retrospective analysis of the clinical data from 75 early-stage EC patients treated at the studied hospital between March 2019 and June 2022. Their ages ranged from 37 to 65 years, with an average age of 53.86±5.77 years. According to FIGO staging, 34 patients were in stage I and 41 were in stage II. In terms of pathology, 64 patients had endometrioid adenocarcinoma, 8 had plasma adenocarcinoma, and 3 had clear-cell carcinoma. The body mass index ranged from 17 to 28 kg/m<span class="elsevierStyleSup">2</span>, with a mean of 22.37 ± 1.84 kg/m<span class="elsevierStyleSup">2</span>. Based on the ASA classification, there were 30 cases in Grade I and 45 in Grade II. Patients were categorized into two groups based on the surgical plan: the 3D group (n = 36) and the open surgery group (n = 39). This study was approved by the Ethics Committee of Ganzhou Cancer Hospital. The research objects were informed, and they signed a fully informed consent form.</p></span><span id="sec0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0011">Inclusion and exclusion criteria</span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0012">Inclusion criteria</span><p id="para0012" class="elsevierStylePara elsevierViewall">Patients meeting the diagnostic criteria for EC,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">10</span></a> as confirmed by surgical pathology. Patients with comprehensive clinical data. Age range of 30‒70 years. FIGO stage I or II. Absence of contraindications to surgery. An anticipated survival time exceeding 6 months. ASA classification of Grade I or II.</p></span><span id="sec0006" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0013">Exclusion criteria</span><p id="para0013" class="elsevierStylePara elsevierViewall">Pregnant or lactating women. Patients with distant tumor metastasis. Those diagnosed with other types of malignancies or possessing severe organ function abnormalities. Individuals with a prior history of uterine surgeries. Patients who had undergone radiotherapy before the study's initiation. Those diagnosed with severe internal diseases or psychiatric disorders.</p></span></span></span><span id="sec0007" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0014">Methods</span><span id="sec0008" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0015">Laparotomy group</span><p id="para0014" class="elsevierStylePara elsevierViewall">The procedure commences with a conventional laparotomy. Sequentially: Anesthesia is administered via endotracheal intubation for general anesthesia. The patient is positioned supinely. A surgical incision, approximately 15 cm in length, is rendered along the midline of the lower abdomen. Upon accessing the abdominal cavity, a meticulous examination of the pelvic conditions is conducted.</p><p id="para0015" class="elsevierStylePara elsevierViewall">The peritoneum is extended to the common iliac artery. Lymph nodes, including the common iliac, internal iliac, external iliac, obturator, and inguinal, are extracted, as is the round ligament. The pelvic infundibuliform ligament is ligated, adjacent uterine tissues are coagulated, and a segment of the vaginal wall is excised for pathological scrutiny. The residual vaginal end is meticulously sutured to preclude active bleeding.</p><p id="para0016" class="elsevierStylePara elsevierViewall">Following the purification of the abdominal cavity, standard closure techniques are implemented.</p></span><span id="sec0009" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0016">3D group</span><p id="para0017" class="elsevierStylePara elsevierViewall">This procedure employs three-dimensional laparoscopic surgery. Specifically: Anesthesia is induced through endotracheal intubation.</p><p id="para0018" class="elsevierStylePara elsevierViewall">The patient assumes the lithotomy position. The medical team don's 3D glasses to afford a stereoscopic visualization of the pelvic region, facilitated by the three-dimensional laparoscopic system. Post-anesthesia, a uterine manipulator is positioned. An incision, approximately 1 cm in length, is made about 2 cm above the navel. The abdominal layers are accessed sequentially, and a 10 mm Trocar is situated to establish a CO<span class="elsevierStyleInf">2</span> pneumoperitoneum, with pressure sustained between 12‒15 mmHg.</p><p id="para0019" class="elsevierStylePara elsevierViewall">A laparoscopic 10 mm Trocar is inserted just above the navel. Subsequent Trocars, of dimensions 10 mm, 5 mm, and 5 mm, are strategically placed at the left McBurney's point, the left rectus abdominis level with the navel, and the right McBurney's point, respectively. The abdominal and pelvic structures undergo a routine assessment.</p><p id="para0020" class="elsevierStylePara elsevierViewall">Any prevalent adhesions are disentangled using either an ultrasonic scalpel or through blunt dissection. The left pelvic infundibuliform ligament is revealed up to the peritoneum and then sectioned. After opening the sheath of the left common iliac artery, the left internal iliac lymph nodes are excised. Lymph nodes, spanning both sides, including common iliac, internal iliac, external iliac, obturator, and inguinal, are extracted. The peritoneum overlaying the abdominal aorta is unsealed, facilitating the removal of some peri-aortic lymph nodes. The round ligament is bisected utilizing an ultrasonic scalpel. Exposure of the pelvic infundibuliform ligament is followed by bipolar coagulation and subsequent severance with an ultrasonic scalpel. Both the vesicouterine pouch and broad ligament are accessed, tissues proximal to the uterus are disassociated, and the uterine artery is exposed and cut. The uterus is meticulously extirpated along the periphery of the uterine manipulator. A comprehensive irrigation of the pelvic region is undertaken. The remaining vaginal end is secured with sutures, ensuring the cessation of any active bleeding. The abdominal cavity is then sanitized, concluding with standard closure procedures.</p></span></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0017">Observation indicators</span><span id="sec0011" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0018">Perioperative parameters</span><p id="para0021" class="elsevierStylePara elsevierViewall">Evaluation of the two groups will involve comparing operation durations, intraoperative hemorrhage, lymph node dissections, time to the first post-operative flatus, catheter retention durations, and lengths of hospital stay.</p></span><span id="sec0012" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0019">Tumor markers</span><p id="para0022" class="elsevierStylePara elsevierViewall">From both groups, 3 mL of venous blood is collected on an empty stomach during the early morning, both pre-operatively and 3 days post-operatively. Following a 10 min centrifugation at 3000 rpm (radius of 6 cm), the supernatant serum is transferred to 1.5 mL EP tubes and stored at -80°C for subsequent analysis. Electrochemiluminescence will be employed to determine glycan antigen levels (CA125, CA199) and Human Epididymal secretion protein 4 (HE4). The kits are supplied by Beijing Kang Rui Na Biotechnology Co.</p></span><span id="sec0013" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0020">Coagulation metrics</span><p id="para0023" class="elsevierStylePara elsevierViewall">Indices such as Fibrinogen (FIB), Prothrombin Time (PT), and Activated Partial Thromboplastin Time (APTT) will be gauged using an automated hematology analyzer in both groups before and 3-days following the surgery.</p></span><span id="sec0014" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0021">Immune profiling</span><p id="para0024" class="elsevierStylePara elsevierViewall">The subsets of T-lymphocytes (CD3+, CD4+, CD8+, and CD4+/CD8+ ratios) are quantified by flow cytometry for both cohorts, both pre-surgery and 3 days post-surgery.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0022">Inflammatory markers</span><p id="para0025" class="elsevierStylePara elsevierViewall">3 mL of venous blood, drawn from fasting subjects in the early morning, will be obtained from both groups before and 3 days after the procedure. Post a 10 min centrifugation (3000 rpm with a 6 cm radius), the resultant serum is secured in 1.5 mL EP tubes and refrigerated at -80°C until analysis. Levels of Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-6 (IL-6), and Procalcitonin (PCT) will be assayed using the ELISA technique. The diagnostic kits are courtesy of Bohui Biotechnology (Guangzhou) Co.</p></span><span id="sec0016" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0023">Urinary function assessment</span><p id="para0026" class="elsevierStylePara elsevierViewall">Both groups will undergo evaluations of residual urine volume, peak urinary flow, average urinary flow, and maximal urethral pressure using urodynamic measurements, conducted both pre-surgery and 3 months post-surgery.</p></span><span id="sec0017" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0024">Quality-of-life analysis</span><p id="para0027" class="elsevierStylePara elsevierViewall">The well-being of subjects from both groups will be assessed by employing the Quality-of-Life Assessment Scale for Cancer Patients (QLQ-30).<a class="elsevierStyleCrossRef" href="#bib0011"><span class="elsevierStyleSup">11</span></a> This evaluation, conducted both pre-surgery and 3 months post-surgery, encompasses four dimensions: social relationships, physiological functionality, psychological health, and environmental factors. Each dimension carries a maximum score of 100, with diminished scores indicative of poorer quality-of-life.</p></span><span id="sec0018" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0025">Post-operative complications</span><p id="para0028" class="elsevierStylePara elsevierViewall">These may comprise urinary retention, wound infections, lymphocele formation, and intestinal obstructions, among others.</p></span><span id="sec0019" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0026">Statistical analysis</span><p id="para0029" class="elsevierStylePara elsevierViewall">The data was processed and analyzed using SPSS version 24.0 software. Continuous variables such as perioperative parameters, serum tumor markers, coagulation metrics, immune profiling, inflammatory markers, urinary function, and quality of life metrics were presented as mean ± Standard Deviation (χ±s). For comparing between groups, the independent samples <span class="elsevierStyleItalic">t</span>-test was employed, while within-group comparisons utilized the paired samples <span class="elsevierStyleItalic">t</span>-test. Categorical data were represented as frequencies (n) with percentages (%) and were compared using the χ<span class="elsevierStyleSup">2</span> test. A p-value less than 0.05 (<span class="elsevierStyleItalic">p</span> < 0.05) was deemed statistically significant.</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0027">Results</span><span id="sec0021" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0028">Clinical data comparison between the laparotomy and 3D groups</span><p id="para0030" class="elsevierStylePara elsevierViewall">There was no statistically significant difference between the two groups in terms of age, FIGO stage, pathological type, body mass index, and ASA classification (p > 0.05). Refer to <a class="elsevierStyleCrossRef" href="#tbl0001">Table 1</a> for details.</p><elsevierMultimedia ident="tbl0001"></elsevierMultimedia></span><span id="sec0022" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0029">Perioperative indexes comparison between the laparotomy and 3D groups</span><p id="para0031" class="elsevierStylePara elsevierViewall">The 3D group demonstrated reduced intraoperative bleeding, earlier time to first flatus, shorter catheter retention, and reduced hospitalization duration compared to the laparotomy group (<span class="elsevierStyleItalic">p</span> < 0.05). However, the operation time and the number of lymph nodes dissected showed no significant differences between the two groups (p > 0.05). Further information can be found in <a class="elsevierStyleCrossRef" href="#tbl0002">Table 2</a>.</p><elsevierMultimedia ident="tbl0002"></elsevierMultimedia></span><span id="sec0023" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0030">Tumor marker levels comparison between the laparotomy and 3D groups</span><p id="para0032" class="elsevierStylePara elsevierViewall">There were no significant differences in preoperative levels of CA125, CA199, and HE4 between the two groups (p > 0.05). Postoperatively at 3 days, both groups exhibited a decline in CA125, CA199, and HE4 levels; however, these levels were more pronouncedly decreased in the 3D group compared to the laparotomy group (<span class="elsevierStyleItalic">p</span> < 0.05). See <a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a> for a visual representation.</p><elsevierMultimedia ident="fig0001"></elsevierMultimedia><span id="sec0024" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0031">Coagulation function comparison between the laparotomy and 3D groups</span><p id="para0033" class="elsevierStylePara elsevierViewall">No statistically significant differences were observed in the preoperative levels of FIB, PT, and APTT between the two groups (p > 0.05). At 3 days post-operation, the FIB level in both groups rose, being notably higher in the 3D group than in the laparotomy group. Conversely, PT and APTT durations were reduced, and these reductions were more significant in the 3D group (<span class="elsevierStyleItalic">p</span> < 0.05). Refer to <a class="elsevierStyleCrossRef" href="#fig0002">Fig. 2</a> for details.</p><elsevierMultimedia ident="fig0002"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0032">Immune function comparison between the laparotomy and 3D groups</span><p id="para0034" class="elsevierStylePara elsevierViewall">Comparing the preoperative levels of CD3+, CD4+, CD4+/CD8+, and CD8+, no significant disparities were identified between the groups (p > 0.05). At 3-days post-surgery, both groups presented a decrease in CD3+, CD4+, and CD4+/CD8+ levels, but these levels remained higher in the 3D group. In contrast, CD8+ levels increased in both groups but were less elevated in the 3D group (<span class="elsevierStyleItalic">p</span> < 0.05). These variations are illustrated in <a class="elsevierStyleCrossRef" href="#fig0003">Fig. 3</a>.</p><elsevierMultimedia ident="fig0003"></elsevierMultimedia></span><span id="sec0026" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0033">Inflammatory response comparison between the laparotomy and 3D groups</span><p id="para0035" class="elsevierStylePara elsevierViewall">There was no significant difference between the two groups in preoperative levels of TNF-α, IL-6, and PCT (p > 0.05). However, postoperative day 3 saw an elevation in TNF-α, IL-6, and PCT levels in both groups, with the 3D group having lower levels than the laparotomy group (<span class="elsevierStyleItalic">p</span> < 0.05). This data is depicted in <a class="elsevierStyleCrossRef" href="#fig0004">Fig. 4</a>.</p><elsevierMultimedia ident="fig0004"></elsevierMultimedia></span><span id="sec0027" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0034">Urinary function comparison between the laparotomy and 3D groups</span><p id="para0036" class="elsevierStylePara elsevierViewall">No significant differences in preoperative urinary function indicators were observed between the two groups (p > 0.05). Three months post-surgery, both groups manifested an increase in residual urine volume, with the 3D group showing a lesser increase than the laparotomy group. Meanwhile, maximal urinary flow rate, average urinary flow rate, and maximum urethral pressure displayed decreases, but these decreases were less substantial in the 3D group (<span class="elsevierStyleItalic">p</span> < 0.05). Refer to <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 5</a> for insights.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0028" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0035">Quality of life comparison between the laparotomy and 3D groups</span><p id="para0037" class="elsevierStylePara elsevierViewall">Comparative assessment of preoperative quality of life scores between the two groups revealed no significant difference (p > 0.05). Nonetheless, at 3 months post-operation, both groups recorded increased QLQ-30 index scores, with the scores being notably higher in the 3D group (<span class="elsevierStyleItalic">p</span> < 0.05). Further details are illustrated in <a class="elsevierStyleCrossRef" href="#fig0006">Fig. 6</a>.</p><elsevierMultimedia ident="fig0006"></elsevierMultimedia></span><span id="sec0029" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0036">Complication rates comparison between the laparotomy and 3D groups</span><p id="para0038" class="elsevierStylePara elsevierViewall">The 3D group exhibited a lower complication rate of 5.56 %, in contrast to 25.64 % in the laparotomy group (<span class="elsevierStyleItalic">p</span> < 0.05). Comprehensive data is presented in <a class="elsevierStyleCrossRef" href="#tbl0003">Table 3</a>.</p><elsevierMultimedia ident="tbl0003"></elsevierMultimedia></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0037">Discussion</span><p id="para0039" class="elsevierStylePara elsevierViewall">Endometrial Cancer (EC) stands as a prevalent malignancy in gynecology, predominantly afflicting postmenopausal senior women. The etiology of EC is multifaceted, and predominantly linked to hypertension, cardiovascular diseases, genetic predisposition, obesity, and prolonged estrogen exposure.<a class="elsevierStyleCrossRef" href="#bib0012"><span class="elsevierStyleSup">12</span></a> In contemporary medical practices, early-stage EC patients are primarily chosen for surgical interventions, which demonstrate significant efficacy.<a class="elsevierStyleCrossRef" href="#bib0013"><span class="elsevierStyleSup">13</span></a> However, traditional laparotomy often subjects patients to pronounced trauma and increased postoperative complications, adversely affecting their prognosis.<a class="elsevierStyleCrossRef" href="#bib0014"><span class="elsevierStyleSup">14</span></a> Though laparoscopic surgery promises reduced patient trauma and fewer postoperative complications, it suffers from a limited spatial orientation and depth perception, rendering it challenging.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">15</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0016"><span class="elsevierStyleSup">16</span></a></p><p id="para0040" class="elsevierStylePara elsevierViewall">In the present research, the authors integrated 3D laparoscopic techniques for patients with early EC. Data indicates that the 3D cohort experienced reduced intraoperative bleeding, lesser anal exhaustion, shorter catheter retention and hospital stays, and a diminished complication rate (5.56 %) as opposed to the laparotomy group's 25.64 %. Furthermore, voiding function and quality of life, assessed three months post-surgery, were superior in the 3D group (<span class="elsevierStyleItalic">p</span> < 0.05). This suggests that for early-stage EC, 3D laparoscopy, in contrast to traditional laparotomy, offers precision, fewer complications, expedited recovery, and supplementary benefits. These can actively bolster urinary function restoration and elevate life quality. Factors contributing to these benefits include 3D laparoscopy's ability to offer surgeons a three-dimensional viewpoint, enhancing tissue structure differentiation and meticulous operation, Facilitating direct lesion site identification, allowing comprehensive cancerous tissue and metastatic lymphocyte removal, and Assisting precise adhesion differentiation between the lesion and adjacent tissues, preventing cancer cell proliferation and limiting damage to surrounding structures.<a class="elsevierStyleCrossRef" href="#bib0017"><span class="elsevierStyleSup">17</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0018"><span class="elsevierStyleSup">18</span></a></p><p id="para0041" class="elsevierStylePara elsevierViewall">Tumor markers, notably CA125, CA199, and HE4, play a pivotal role in EC's pathological trajectory.<a class="elsevierStyleCrossRef" href="#bib0019"><span class="elsevierStyleSup">19</span></a> Notably, CA125, an endometrial-secreted glycoprotein antigen, stands out as a primary EC diagnostic tool. Investigations by Kakimoto S et al.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">20</span></a> revealed markedly elevated serum CA125 levels in EC patients compared to a healthy control group. CA199, a tumor-affiliated antigen, correlates with EC's invasive potential and mirrors patient prognosis. Meanwhile, HE4, an expressed glycoprotein in ovarian and endometrial cancers, further underscores its significance. The present findings highlight that postoperative 3D group patients had significantly reduced serum CA125, CA199, and HE4 levels compared to their laparotomy counterparts (<span class="elsevierStyleItalic">p</span> < 0.05). This might be attributed to 3D laparoscopy's precision and comprehensive lesion excision capabilities.</p><p id="para0042" class="elsevierStylePara elsevierViewall">Surgical trauma can compromise immune function, disturb coagulation mechanisms, and escalate risks like secondary infections.<a class="elsevierStyleCrossRef" href="#bib0021"><span class="elsevierStyleSup">21</span></a> Studies, including those by Qian Junxiong,<a class="elsevierStyleCrossRef" href="#bib0022"><span class="elsevierStyleSup">22</span></a> observed hypercoagulability in malignancy patients. Herein, FIB offers insights into coagulation status, while PT and APTT shifts correlate with coagulation factor concentrations. Surgical stress responses can suppress both humoral and cellular immunity and catalyze inflammatory agents like TNF-α, IL-6, and PCT, influencing post-surgical recuperation.<a class="elsevierStyleCrossRef" href="#bib0023"><span class="elsevierStyleSup">23</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0024"><span class="elsevierStyleSup">24</span></a> These observations underscore that, compared to traditional laparotomy, 3D laparoscopic surgery could effectively mitigate inflammatory and immunological repercussions in early EC patients, albeit influencing coagulation more. This discrepancy may arise from 3D laparoscopy-induced hypercoagulability due to pneumoperitoneum establishment, venous stasis from specific positioning, and the activation of the fibrinolytic system.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">25</span></a></p><p id="para0043" class="elsevierStylePara elsevierViewall">However, during the surgical procedure, the authors encountered several challenges related to the 3D technology. Firstly, for those wearing 3D glasses for the first time, there was an initial discomfort and a required focus adjustment. This transition often led to eye strain and necessitated an acclimatization period. Secondly, the frequent transition between 3D stereoscopic vision and 2D planar vision during the operation resulted in visual fatigue, soreness, and other discomforts, such as eye irritation, especially after extended use of 3D glasses. Lastly, beginners to the 3D laparoscopic technique often perceive an exaggerated depth in the surgical field. This could easily lead to a misjudgment of the operative field's depth, necessitating a brief adaptation period.</p></span><span id="sec0031" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0038">Conclusion</span><p id="para0044" class="elsevierStylePara elsevierViewall">In conclusion, when juxtaposed with traditional laparotomy, 3D laparoscopic surgery for early EC exhibits remarkable precision. It offers distinct advantages, such as reduced complications, expedited recovery, effective reduction in serum tumor marker levels, decreased inflammatory responses, minimized immune function damage, enhanced urinary function recovery, and improved quality of life. However, it notably impacts the patient's coagulation function, necessitating vigilant prevention and management of thrombotic events in clinical settings. Yet, it's pertinent to note that the present study is characterized by its small sample size and its retrospective, single-center nature. These factors might introduce potential biases. Moreover, the present research did not delve into the long-term recurrence and prognosis of early EC patients’ post-3D laparoscopic surgery. Thus, there is an eager anticipation for extensive, prospective research in the future to provide a more comprehensive understanding.</p></span><span id="sec0032" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0039">Funding</span><p id="para0045" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</p></span><span id="sec0032a" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0039a">CRediT authorship contribution statement</span><p id="para0045a" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Hailong Chen:</span> Visualization, Writing – original draft. <span class="elsevierStyleBold">Dechang Xu:</span> Visualization, Writing – original draft. <span class="elsevierStyleBold">Ying Yu:</span> Formal analysis, Data curation. <span class="elsevierStyleBold">Jing Huang:</span> Formal analysis, Data curation. <span class="elsevierStyleBold">Qian Zhou:</span> Formal analysis, Data curation. <span class="elsevierStyleBold">Qi Wang:</span> Visualization, Writing – review & editing.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres2290881" "titulo" => "Highlights" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abss0001" ] ] ] 1 => array:3 [ "identificador" => "xres2290880" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0002" "titulo" => "Objectives" ] 1 => array:2 [ "identificador" => "abss0003" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abss0004" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0005" "titulo" => "Conclusions" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1903289" "titulo" => "Keywords" ] 3 => array:2 [ "identificador" => "sec0001" "titulo" => "Introduction" ] 4 => array:3 [ "identificador" => "sec0002" "titulo" => "Materials and methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0003" "titulo" => "Clinical data" ] 1 => array:3 [ "identificador" => "sec0004" "titulo" => "Inclusion and exclusion criteria" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Inclusion criteria" ] 1 => array:2 [ "identificador" => "sec0006" "titulo" => "Exclusion criteria" ] ] ] ] ] 5 => array:3 [ "identificador" => "sec0007" "titulo" => "Methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0008" "titulo" => "Laparotomy group" ] 1 => array:2 [ "identificador" => "sec0009" "titulo" => "3D group" ] ] ] 6 => array:3 [ "identificador" => "sec0010" "titulo" => "Observation indicators" "secciones" => array:9 [ 0 => array:2 [ "identificador" => "sec0011" "titulo" => "Perioperative parameters" ] 1 => array:2 [ "identificador" => "sec0012" "titulo" => "Tumor markers" ] 2 => array:2 [ "identificador" => "sec0013" "titulo" => "Coagulation metrics" ] 3 => array:2 [ "identificador" => "sec0014" "titulo" => "Immune profiling" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Inflammatory markers" ] 5 => array:2 [ "identificador" => "sec0016" "titulo" => "Urinary function assessment" ] 6 => array:2 [ "identificador" => "sec0017" "titulo" => "Quality-of-life analysis" ] 7 => array:2 [ "identificador" => "sec0018" "titulo" => "Post-operative complications" ] 8 => array:2 [ "identificador" => "sec0019" "titulo" => "Statistical analysis" ] ] ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Results" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "sec0021" "titulo" => "Clinical data comparison between the laparotomy and 3D groups" ] 1 => array:2 [ "identificador" => "sec0022" "titulo" => "Perioperative indexes comparison between the laparotomy and 3D groups" ] 2 => array:3 [ "identificador" => "sec0023" "titulo" => "Tumor marker levels comparison between the laparotomy and 3D groups" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0024" "titulo" => "Coagulation function comparison between the laparotomy and 3D groups" ] ] ] 3 => array:2 [ "identificador" => "sec0025" "titulo" => "Immune function comparison between the laparotomy and 3D groups" ] 4 => array:2 [ "identificador" => "sec0026" "titulo" => "Inflammatory response comparison between the laparotomy and 3D groups" ] 5 => array:2 [ "identificador" => "sec0027" "titulo" => "Urinary function comparison between the laparotomy and 3D groups" ] 6 => array:2 [ "identificador" => "sec0028" "titulo" => "Quality of life comparison between the laparotomy and 3D groups" ] 7 => array:2 [ "identificador" => "sec0029" "titulo" => "Complication rates comparison between the laparotomy and 3D groups" ] ] ] 8 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "sec0031" "titulo" => "Conclusion" ] 10 => array:2 [ "identificador" => "sec0032" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "sec0032a" "titulo" => "CRediT authorship contribution statement" ] 12 => array:2 [ "identificador" => "xack786224" "titulo" => "Acknowledgment" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2023-12-01" "fechaAceptado" => "2024-01-14" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1903289" "palabras" => array:4 [ 0 => "Endometrial cancer" 1 => "Early stage" 2 => "3D laparoscopic surgery" 3 => "Laparotomy" ] ] ] ] "tieneResumen" => true "highlights" => array:2 [ "titulo" => "Highlights" "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><p id="spara010" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001"><span class="elsevierStyleLabel">•</span><p id="para0002" class="elsevierStylePara elsevierViewall">3D laparoscopic surgery for early-stage EC seems to be more effective than traditional laparotomy.</p></li><li class="elsevierStyleListItem" id="celistitem0002"><span class="elsevierStyleLabel">•</span><p id="para0003" class="elsevierStylePara elsevierViewall">3D laparoscopic surgery for early EC can attenuate the inflammatory response and damage to immune function, foster urinary function recovery, and enhance the quality of life.</p></li><li class="elsevierStyleListItem" id="celistitem0003"><span class="elsevierStyleLabel">•</span><p id="para0004" class="elsevierStylePara elsevierViewall">3D laparoscopic surgery for early EC impacts the patient's coagulation function, necessitating vigilant prevention and management of thrombotic events in clinical settings.</p></li></ul></p></span>" ] "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Objectives</span><p id="spara011" class="elsevierStyleSimplePara elsevierViewall">To investigate the impact of Three-Dimensional (3D) laparoscopy compared to traditional laparotomy on serum tumor markers and coagulation function in patients diagnosed with early-stage Endometrial Cancer (EC).</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Method</span><p id="spara012" class="elsevierStyleSimplePara elsevierViewall">The authors retrospectively analyzed the clinical data of 75 patients diagnosed with early-stage EC and categorized them into two groups based on the surgical techniques employed. The 3D group consisted of 36 patients who underwent 3D laparoscopic surgery, while the Laparotomy group comprised 39 patients who underwent traditional laparotomy. The authors then compared the alterations in serum tumor markers and coagulation function between the two groups.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0005">Results</span><p id="spara013" class="elsevierStyleSimplePara elsevierViewall">Postoperatively, serum levels of CA125, CA199, and HE4 were notably reduced in both groups on the third day, with the levels being more diminished in the 3D group than in the Laparotomy Group (<span class="elsevierStyleItalic">p</span> < 0.05). Conversely, FIB levels escalated significantly in both groups on the third-day post-surgery, with a more pronounced increase in the 3D group. Additionally, PT and APTT durations were reduced and were more so in the 3D group than in the laparotomy group (<span class="elsevierStyleItalic">p</span> < 0.05).</p></span> <span id="abss0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0006">Conclusions</span><p id="spara014" class="elsevierStyleSimplePara elsevierViewall">When juxtaposed with traditional laparotomy, 3D laparoscopic surgery for early-stage EC appears to be more efficacious, characterized by reduced complications, and expedited recovery. It can effectively mitigate serum tumor marker levels, attenuate the inflammatory response and damage to immune function, foster urinary function recovery, and enhance the quality of life. However, it exerts a more significant influence on the patient's coagulation parameters, necessitating meticulous prevention and treatment strategies for thromboembolic events in clinical settings.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0002" "titulo" => "Objectives" ] 1 => array:2 [ "identificador" => "abss0003" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abss0004" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0005" "titulo" => "Conclusions" ] ] ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="notep0001">Both authors contributed equally to this work and should be considered as equal first coauthors.</p>" "identificador" => "fn1" ] ] "multimedia" => array:9 [ 0 => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 935 "Ancho" => 3167 "Tamanyo" => 241133 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0004" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Comparative analysis of tumor marker levels in early-stage endometrial cancer patients following 3D laparoscopy and traditional laparotomy. <a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a> illustrates the postoperative serum levels of (A) CA125, (B) CA199, and (C) HE4 tumor markers. Notably, three days post-surgery, there was a pronounced reduction in the levels of all these markers in both the 3D laparoscopic group and the laparotomy group. Nevertheless, the decrease was more prominent in the 3D laparoscopic group compared to the laparotomy group (<span class="elsevierStyleItalic">p</span> < 0.05). Note: Compared with the preoperative period, *** <span class="elsevierStyleItalic">p</span> < 0.001; compared with the laparotomy group, ### <span class="elsevierStyleItalic">p</span> < 0.001.</p>" ] ] 1 => array:8 [ "identificador" => "fig0002" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 953 "Ancho" => 3167 "Tamanyo" => 148644 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0005" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Comparative assessment of coagulation function indicators in early endometrial cancer patients following 3D laparoscopy and traditional laparotomy. <a class="elsevierStyleCrossRef" href="#fig0002">Fig. 2</a> delineates the postoperative status of coagulation function indicators three days after surgery. Specifically, (A) FIB levels surged in both groups, with a more pronounced elevation in the 3D laparoscopic group compared to the laparotomy group. Conversely, durations for both (B) PT and (C) APTT diminished, with these reductions being more marked in the 3D laparoscopic group than in the laparotomy group. Note: Compared with the preoperative period, <span class="elsevierStyleSup">⁎⁎</span><span class="elsevierStyleItalic">* p</span> < 0.001; compared with the laparotomy group, <span class="elsevierStyleSup">###</span><span class="elsevierStyleItalic">p</span> < 0.001.</p>" ] ] 2 => array:8 [ "identificador" => "fig0003" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2970 "Ancho" => 3167 "Tamanyo" => 356537 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0006" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Comparative evaluation of immune function indicators in early endometrial cancer patients following 3D laparoscopy and traditional laparotomy. <a class="elsevierStyleCrossRef" href="#fig0003">Fig. 3</a> illustrates the postoperative changes in immune function indicators three days after surgery. Specifically: (A) CD3+ levels decreased in both surgical groups yet remained relatively higher in the 3D laparoscopic group compared to the laparotomy group. (B) CD4+ levels followed a similar trend, with the 3D laparoscopic group showing a lesser decline than the laparotomy group. (C) CD8+ levels, on the other hand, exhibited an increase postoperatively in both groups. Notably, this increase was more pronounced in the 3D laparoscopic group than in the laparotomy group. (D) The CD4+/CD8+ ratio also declined post-surgery, but this decline was less significant in the 3D laparoscopic group when compared to the laparotomy group. Note: Compared with the preoperative period, <span class="elsevierStyleItalic">p</span> < 0.001; compared with the laparotomy group, <span class="elsevierStyleSup">###</span><span class="elsevierStyleItalic">p</span> < 0.001.</p>" ] ] 3 => array:8 [ "identificador" => "fig0004" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 999 "Ancho" => 3167 "Tamanyo" => 247352 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0007" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Comparative analysis of inflammatory response indicators in early endometrial cancer patients after 3D laparoscopy and traditional laparotomy. <a class="elsevierStyleCrossRef" href="#fig0004">Fig. 4</a> delineates the variation in postoperative inflammatory response markers: (A) TNF-α levels surged in both surgical cohorts three days after surgery but exhibited a more subdued rise in the 3D laparoscopic group compared to the laparotomy group. (B) IL-6 and (C) PCT followed a similar trend, presenting heightened levels, with the 3D laparoscopic group showing relatively lower increments than the laparotomy group. Note: Compared with the preoperative period, <span class="elsevierStyleItalic">p</span> < 0.001; compared with the laparotomy group, <span class="elsevierStyleSup">###</span><span class="elsevierStyleItalic">p</span> < 0.001.</p>" ] ] 4 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 3003 "Ancho" => 3167 "Tamanyo" => 631644 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0008" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara005" class="elsevierStyleSimplePara elsevierViewall">Assessment of inflammatory response indicators post 3D laparoscopic and traditional laparotomy in early endometrial cancer patients. Three months post-surgery, <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 5</a> reveals: (A) A marked increase in residual urine volume in both groups. However, this increase was less pronounced in the 3D laparoscopic group. (B) The maximum urinary flow rate and (C) The average urinary flow rate were discernibly reduced, yet these reductions were less substantial in the 3D laparoscopic group. (D) Conversely, the maximal pressure exerted by the forced urethral muscle was elevated, with the 3D laparoscopic group exhibiting a greater increase than the laparotomy group. Note: Compared with the preoperative period, <span class="elsevierStyleItalic">p</span> < 0.001; compared with the laparotomy group, <span class="elsevierStyleSup">###</span><span class="elsevierStyleItalic">p</span> < 0.001.</p>" ] ] 5 => array:8 [ "identificador" => "fig0006" "etiqueta" => "Fig. 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 3089 "Ancho" => 3167 "Tamanyo" => 671708 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0009" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara006" class="elsevierStyleSimplePara elsevierViewall">Evaluating the impact of 3D laparoscopy and traditional laparotomy on quality-of-life metrics in early endometrial cancer patients. Fig. 6 provides insights into the QLQ-30 scores for various domains three months post-surgery: (A) The social relationship score, (B) Physical function score, (C) Psychological function score, and (D) Environmental domain score all experienced a notable enhancement in both surgical groups. Crucially, each of these scores was markedly superior in the 3D laparoscopic group compared to the laparotomy group. Note: Compared with the preoperative period, <span class="elsevierStyleItalic">p</span> < 0.001; compared with the laparotomy group, <span class="elsevierStyleSup">###</span><span class="elsevierStyleItalic">p</span> < 0.001.</p>" ] ] 6 => array:8 [ "identificador" => "tbl0001" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0001"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowgroup " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group</th><a name="en0002"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowgroup " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age (years)</th><a name="en0003"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">FIGO Staging</th><a name="en0004"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Pathology type</th><a name="en0005"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowgroup " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Body mass index (kg/m<span class="elsevierStyleSup">2</span>)</th><a name="en0006"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ASA grading</th></tr><tr title="table-row"><a name="en0009"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Stage I \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0010"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Stage II \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0011"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Endometrioid adenocarcinoma \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0012"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Plasma adenocarcinoma \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0013"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Clear cell carcinoma \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0015"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Grade I \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0016"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Class II \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0017"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Laparotomy group (n = 39) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0018"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">53.72 ± 6.15 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0019"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0020"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0021"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">34 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0022"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0023"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0024"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">22.49 ± 2.06 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0025"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0026"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0027"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">3D Group (n = 36) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0028"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">54.08 ± 6.37 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0029"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0030"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0031"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0032"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0033"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0034"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">22.21 ± 1.97 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0035"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0036"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0037"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"><span class="elsevierStyleItalic">t</span>/χ<span class="elsevierStyleSup">2</span> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0038"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.249 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0039"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="top">0.022</td><a name="en0040"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="3" align="left" valign="top">0.197</td><a name="en0041"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.601 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0042"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="top">0.436</td></tr><tr title="table-row"><a name="en0043"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">p \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0044"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.804 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0045"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="top">0.882</td><a name="en0046"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="3" align="left" valign="top">0.844</td><a name="en0047"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.550 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0048"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="top">0.509</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3711521.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara007" class="elsevierStyleSimplePara elsevierViewall">Comparison of clinical data n/(χ±S).</p>" ] ] 7 => array:8 [ "identificador" => "tbl0002" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0002" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0049"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0050"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Operation time (min) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0051"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Intraoperative bleeding volume (mL) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0052"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Number of lymphatic dissection (pcs) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0053"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Time to first flatus (h) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0054"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Catheter indwelling time (d) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0055"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Length of hospitalization (d) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0056"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Laparotomy group (n = 39) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0057"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">185.69 ± 22.85 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0058"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">258.65 ± 18.23 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0059"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">19.58 ± 2.14 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0060"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">37.89 ± 2.92 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0061"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">2.79 ± 0.86 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0062"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">11.75 ± 2.15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0063"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">3D Group (n = 36) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0064"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">187.45 ± 19.74 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0065"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">182.41 ± 20.05 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0066"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">20.01 ± 2.02 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0067"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">30.57 ± 3.14 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0068"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">1.83 ± 1.02 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0069"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">8.43 ± 1.67 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0070"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"><span class="elsevierStyleItalic">t</span> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0071"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.356 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0072"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">17.249 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0073"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.893 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0074"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">10.461 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0075"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">4.418 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0076"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">7.424 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0077"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">p \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0078"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.723 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0079"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">< 0.001 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0080"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.375 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0081"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">< 0.001 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0082"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">< <span class="elsevierStyleItalic">p</span> < 0.001 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0083"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.375 < 0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3711522.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara008" class="elsevierStyleSimplePara elsevierViewall">Comparison of perioperative indexes (χ±S).</p>" ] ] 8 => array:8 [ "identificador" => "tbl0003" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0003" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0084"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0085"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Urinary retention \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0086"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Incision infection \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0087"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Lymphocysts \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0088"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Intestinal obstruction \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0089"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0090"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Laparotomy group (n = 39) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0091"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">3 (7.69) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0092"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">3 (7.69) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0093"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">3 (7.69) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0094"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">1 (2.56) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0095"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">10 (25.64) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0096"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">3D Group (n = 36) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0097"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">1 (2.78) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0098"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">1 (2.78) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0099"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0100"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0101"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">2 (5.56) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0102"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">χ<span class="elsevierStyleSup">2</span> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0103"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0104"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0105"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0106"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0107"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">5.619 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0108"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">p \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0109"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0110"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0111"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0112"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0113"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.018 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3711523.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara009" class="elsevierStyleSimplePara elsevierViewall">Comparison of complications n (%).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec1" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib0001" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cost-effectiveness of robotic hysterectomy versus abdominal hysterectomy in early endometrial cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.S. 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Year/Month | Html | Total | |
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2024 November | 6 | 0 | 6 |
2024 October | 43 | 22 | 65 |
2024 September | 46 | 23 | 69 |
2024 August | 52 | 20 | 72 |
2024 July | 51 | 20 | 71 |
2024 June | 29 | 15 | 44 |
2024 May | 40 | 13 | 53 |
2024 April | 60 | 16 | 76 |
2024 March | 56 | 30 | 86 |
2024 February | 42 | 38 | 80 |