Changes of GH-IGFs and its relationship with growth retardation in children with bronchial asthma

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(A) The solid red line represents the smooth curve fit between variables. Blue bands represent the 95 % Confidence Interval from the fit. (B) Smoothed curve results stratified by gender. LSM, Liver Stiffness Median." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Zhiming Lu, Shaojie Wu, Eryou Feng, Xiaoli Chen, Jinhua Chen, Feitai Lin" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Zhiming" "apellidos" => "Lu" ] 1 => array:2 [ "nombre" => "Shaojie" "apellidos" => "Wu" ] 2 => array:2 [ "nombre" => "Eryou" "apellidos" => "Feng" ] 3 => array:2 [ "nombre" => "Xiaoli" "apellidos" => "Chen" ] 4 => array:2 [ "nombre" => "Jinhua" "apellidos" => "Chen" ] 5 => array:2 [ "nombre" => "Feitai" "apellidos" => "Lin" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001">•Positive correlation between arthritis and hepatic steatosis, particularly in women.</li><li class="elsevierStyleListItem" id="celistitem0002">•No significant relationship between arthritis and the risk of liver fibrosis.</li><li class="elsevierStyleListItem" id="celistitem0003">•First study to examine the association between arthritis and both liver steatosis and fibrosis.</li></ul>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593224000553?idApp=UINPBA00004N" "url" => "/18075932/000000790000000C/v123_202411010523/S1807593224000553/v123_202411010523/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "Original articles" "titulo" => "Changes of GH-IGFs and its relationship with growth retardation in children with bronchial asthma" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Li Li, Lihua Qiu, Junchao Xia, Yichun Xiao, Li Zhao, Haiyan Wang" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Li" "apellidos" => "Li" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "1" "identificador" => "fn1" ] ] ] 1 => array:3 [ "nombre" => "Lihua" "apellidos" => "Qiu" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0002" ] 1 => array:2 [ "etiqueta" => "1" "identificador" => "fn1" ] ] ] 2 => array:3 [ "nombre" => "Junchao" "apellidos" => "Xia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] ] ] 3 => array:3 [ "nombre" => "Yichun" "apellidos" => "Xiao" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] ] ] 4 => array:3 [ "nombre" => "Li" "apellidos" => "Zhao" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0003" ] ] ] 5 => array:4 [ "nombre" => "Haiyan" "apellidos" => "Wang" "email" => array:1 [ 0 => "wanghaiyan8009@outlook.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0003" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0001" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Pediatrics, Ganzhou People's Hospital, Ganzhou City, Jiangxi Province, China" "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Department of Pediatrics, Huaian Hospital of Huaian City, Huaian City, Jiangsu Province, China" "etiqueta" => "b" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Department of Pediatrics, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang City, Hebei Province, China" "etiqueta" => "c" "identificador" => "aff0003" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0001" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0002" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 840 "Ancho" => 3167 "Tamanyo" => 230623 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0005" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "GH-IGFs-related parameters in patients with different severity of bronchial asthma." ] ] ] "textoCompleto" => "IntroductionPediatric bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation. At the onset of the disease, sporadic or diffuse wheezing rale in the expiratory phase can be heard in both lungs, and patients are often accompanied by variable expiratory airflow limitation, recurrent wheezing, shortness of breath, chest tightness, or cough. Bronchial asthma is a chronic inflammation involving a variety of inflammatory cells, which can cause airway damage, and then lead to airway smooth muscle thickening.<a class="elsevierStyleCrossRef" href="#bib0001">1</a> Insulin-like Growth Factor-1 (IGF-1) is involved in the repair process of airway epithelium and alveolar injury.<a class="elsevierStyleCrossRef" href="#bib0002">2</a> It has been reported in the past that the growth of airway epithelial cells can be promoted by regulating IGF-1 concentration.<a class="elsevierStyleCrossRef" href="#bib0003">3</a> IGFs are a class of insulin-like peptides that promote cell differentiation and proliferation and are the main factors in the Growth Hormone (GH) - Insulin-like Growth Factors (GH-IGFs). There is a feedback regulatory system between IGF-1 and GH. GH can promote the synthesis and release of IGF-1, while IGF-1 can increase the hypothalamic somatostatin secretion and inhibit the release of GH or directly inhibit the synthesis of GH by pituitary GH cells, thereby reducing GH levels.<a class="elsevierStyleCrossRef" href="#bib0004">4</a> GH-IGFs is related to the growth of children.<a class="elsevierStyleCrossRef" href="#bib0005">5</a> Bone growth and development are mainly regulated by IGF-1′s endocrine function. GH can act on target cells to directly promote cell differentiation and proliferation and stimulate the production of IGF-1 in peripheral tissues.<a class="elsevierStyleCrossRef" href="#bib0006">6</a> However, there is no clear report on its relationship with the growth of children with bronchial asthma. Therefore, the purpose of this study was to explore the relationship between GH-IGFs and growth retardation in children with bronchial asthma to provide a reference for the assessment of the disease and the growth of children.Data and methodsClinical data112 children with bronchial asthma (bronchial asthma group) and 50 healthy children (control group) from January 2021 to January 2022 were studied, showing no significant difference in clinical data between the two groups (p > 0.05, <a class="elsevierStyleCrossRef" href="#tbl0001">Table 1</a>).<elsevierMultimedia ident="tbl0001"></elsevierMultimedia>Inclusion criteria① Meeting the diagnostic criteria for bronchial asthma;<a class="elsevierStyleCrossRef" href="#bib0007">7</a>;② Age < 14 years old;③ Complete clinical data.Exclusion criteria① Severe cardiac, liver and renal dysfunction;② Congenital diseases;③ Intrauterine growth retardation;④ Other lung diseases;⑤ Abnormal thyroid function;⑥ Intracranial tumor disease.Bronchial severityThe bronchial asthma group was divided into grades 1, 2, 3 and 4 according to the Guideline for the diagnosis and optimal management of asthma in children.GH-IGFs-related parameter detectionCentrifuge treatment was conducted on the KDC-1042 high-speed centrifuge (Anhui Zhongke Zhongjia Scientific Instrument Co., Ltd.) at 3000 r/min for 10-min, with the centrifuge radius of 15 cm. Serum was separated to measure GH, IGF-1, and Insulin-like Growth Factor Binding Protein-3 (IGFBP3) on a Lab systems Dragou Wellscan K-3 microplate reader using enzyme-linked immunosorbent assay.Diagnostic criteria for growth retardationThe physical standard of children with developmental delay is 30 % lower than that of children in the same state.<a class="elsevierStyleCrossRef" href="#bib0008">8</a>Outcome measures<ul class="elsevierStyleList" id="celist0002"><li class="elsevierStyleListItem" id="celistitem0007">1)GH-IGFs-related parameters were compared, and the correlation between each parameter and the severity of bronchial asthma was analyzed.</li><li class="elsevierStyleListItem" id="celistitem0008">2)The bronchial asthma group was divided into the growth retardation group and non-growth retardation group according to the growth conditions, and the diagnostic value of GH-IGFs related indicators for growth retardation and its relationship with growth retardation were analyzed.</li></ul>Statistical analysisStatistics were processed using SPSS22.0 software. Enumeration data (%) were compared by χ2 test. Measurement data (x¯ ± s) after the normality test were compared by t-test or multivariate analysis of variance. Spearman test was conducted to analyze the correlation between GH-IGFs and the severity of bronchial asthma. ROC curve was plotted to analyze the diagnostic value of GH-IGFs in growth retardation. Logistic regression was applied to analyze the relationship between GH-IGFs and growth retardation; p < 0.05 meant that the difference was statistically significant.ResultsGH-IGFs-related parametersGH, IGF-1, and IGFBP3 levels in the bronchial asthma group were lower than those in the control group (p < 0.05, <a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a>).<elsevierMultimedia ident="fig0001"></elsevierMultimedia>GH-IGFs-related parameters in patients with different severity of bronchial asthmaGH, IGF-1, and IGFBP3 in patients with bronchial asthma showed a decreasing trend with the severity of the disease (p < 0.05, <a class="elsevierStyleCrossRef" href="#fig0002">Fig. 2</a>).<elsevierMultimedia ident="fig0002"></elsevierMultimedia>Correlation analysis of GH-IGFs-related parameters and severity of bronchial asthmaA negative correlation was found between GH, IGF-1, and IGFBP3 levels and asthma severity (p < 0.05, <a class="elsevierStyleCrossRef" href="#fig0003">Fig. 3</a>).<elsevierMultimedia ident="fig0003"></elsevierMultimedia>GH-IGFs-related parameters in patients with or without growth retardationGH, IGF-1, and IGFBP3 in the growth retardation group were lower than those in the non-growth retardation group (p < 0.05, <a class="elsevierStyleCrossRef" href="#fig0004">Fig. 4</a>).<elsevierMultimedia ident="fig0004"></elsevierMultimedia>Diagnostic value of GH-IGFs-related indicators in growth retardationThe AUC of the combined detection of GH-IGFs-related indicators in the diagnosis of growth retardation was greater than that of GH and IGFBP3 alone (p < 0.05, <a class="elsevierStyleCrossRef" href="#tbl0002">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 5</a>).<elsevierMultimedia ident="tbl0002"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia>Logistic regression analysis of GH-IGFs-related indicators and growth retardationGH <9.27 μg/L and IGF-1 < 179.53 mmoL/L were risk factors for growth retardation in patients with bronchial asthma (p < 0.05, <a class="elsevierStyleCrossRef" href="#tbl0003">Table 3</a>).<elsevierMultimedia ident="tbl0003"></elsevierMultimedia>DiscussionChildren's bronchial asthma is a respiratory disease that seriously affects children's physical and mental health. As this chronic inflammatory response persists, the airway is in a state of hyper-responsiveness, and the symptoms will occur repeatedly upon stimuli exposure.<a class="elsevierStyleCrossRef" href="#bib0010">9</a> Inflammatory cells are involved in bronchial asthma and cause airway injury and airway smooth muscle thickening.<a class="elsevierStyleCrossRef" href="#bib0011">10</a> IGF-1 is involved in the repair process of airway epithelium and alveolar injury,<a class="elsevierStyleCrossRef" href="#bib0012">11</a> and regulating IGF-1 concentration can promote the growth of airway epithelial cells, suggesting that IGF-1 is involved in the process of airway epithelial cell proliferation.<a class="elsevierStyleCrossRef" href="#bib0013">12</a> Blood IGF-1 can participate in the negative feedback regulation of GH by inhibiting GH expression and transcription in the pituitary gland and stimulating GH release in the hypothalamus. GH can directly act on osteoblasts to promote cell proliferation and increase type I collagen synthesis. IGF-1 can stimulate the repair of osteoblast progenitor cells, and osteoblast differentiation, and induce bone collagen synthesis. IGFBP3 is a polypeptide containing multiple amino acids, which is less responsive to GH than IGF-1. Exogenous GH can increase IGF-1 and IGFBP3 in blood, and IGF-1 infusion can decrease GH concentration, suggesting that the amount of GH in blood is closely related to that of IGF-1.<a class="elsevierStyleCrossRef" href="#bib0014">13</a><a class="elsevierStyleCrossRef" href="#bib0015">14</a> In this study, GH, IGF-1, and IGFBP3 in the bronchial asthma group were lower than those in the control group, indicating the abnormal expression of GH-IGFs in children with bronchial asthma, which may be related to the involvement of IGF-1 in the repair of airway epithelium and alveolar injury. In addition, GH, IGF-1, and IGFBP3 were negatively correlated with the severity of bronchial asthma, suggesting that the severity of the disease could be assessed by detecting GH-IGFs-related parameters.Children's is jointly regulated by the GH-IGFs. GH is secreted by adenohypophysis and regulated by growth hormone releasing hormone. Its growth-promoting effect is mainly mediated by IGF-1 and IGF-2, and IGFs secretion depends on GH. Under normal circumstances, IGF-1 level is mainly regulated by GH, and serum IGF-1 level can reflect the synthesis and release of GH. In blood circulation, IGFBP3 can combine with IGF-1 to form a complex, prolong the half-life of IGF-1 in blood vessels, and increase IGF-1 levels in blood. IGFBP3 can be degraded by IGFBP3 protease, and after degradation, the affinity between IGFBP3 and IGF-1 decreases, thereby releasing more free IGF-1 and enhancing the growth-promoting function of IGF-1.<a class="elsevierStyleCrossRef" href="#bib0016">15</a><a class="elsevierStyleCrossRef" href="#bib0017">16</a>In children, GH-IGFs regulate Children's and metabolism, and the growth-promoting effect of GH is mainly mediated by IGF-1 secreted by the liver.<a class="elsevierStyleCrossRef" href="#bib0018">17</a><a class="elsevierStyleCrossRef" href="#bib0019">18</a> GH binding to GHR in target cells triggers IGFs expression and secretion, wherein IGF-1 enters the tissues by binding to IGFBP, and the growth-promoting and anabolic effects of IGF-1 are triggered by IGF-I binding to IGF-IR in target organs.<a class="elsevierStyleCrossRef" href="#bib0020">19</a><a class="elsevierStyleCrossRef" href="#bib0021">20</a> In this study, GH, IGF-1, and IGFBP3 in the growth retardation group were lower than those in the non-growth retardation group. The AUC of the combined detection of GH-IGFs-related indicators in the diagnosis of growth retardation was greater than that of GH and IGFBP3 alone. In addition, GH < 9.27 μg/L and IGF-1 < 179.53 mmoL/L were risk factors for growth retardation in children with bronchial asthma, indicating that decreased GH and IGF-1 could lead to growth retardation in children. The reason is that GH can stimulate peripheral tissues, especially the liver, to secrete IGF-1, which can promote organ development and activate bone anabolism. The effect of GH on growth is mediated by IGF-1, so abnormal IGF-1 can also affect Children.<a class="elsevierStyleCrossRefs" href="#bib0022">21–23</a>In summary, abnormal GH-IGFs-related indicators exist in children with bronchial asthma, and GH-IGFs-related indicators in children are of diagnostic value for growth and development, and decreased levels of GH and IGF-1 are risk factors for growth retardation in children.Availability of data and materialsThe datasets used and/or analyzed during the present study are available from the corresponding author upon reasonable request.Ethics approvalThe present study was approved by the Ethics Committee of Ganzhou People's Hospital and written informed consent was provided by all patients prior to the study start. All procedures were performed in accordance with the ethical standards of the Institutional Review Board and The Declaration of Helsinki, and its later amendments or comparable ethical standards.Authors’ contributionsLi Li and Lihua Qiu designed the research study. Junchao Xia and Yichun Xiao performed the research. Li Zhao and Haiyan Wang provided help and advice on the experiments. Li Li, Lihua Qiu and Haiyan Wang analyzed the data. Li Li and Lihua Qiu wrote the manuscript. Haiyan Wang reviewed and edited the manuscript. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript.FundingJiangxi Provincial Health and Family Planning Commission Science and Technology Program (SKJP220203187)." 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Methods112 children with bronchial asthma and 50 healthy children were studied. Serum GH, IGF-1, and Insulin-like Growth Factor Binding Protein 3 (IGFBP3) were assessed by ELISA. GH-IGFs-related parameters were compared, and the correlation between the parameters and bronchial asthma severity was analyzed. The bronchial asthma group was divided into the growth retardation group and non-growth retardation group to analyze the diagnostic value of GH-IGFs in growth retardation and the relationship between GH-IGFs and growth retardation. ResultsGH, IGF-1, and IGFBP3 in the bronchial asthma group were lower. GH, IGF-1, and IGFBP3 levels were decreased with the severity of bronchial asthma. GH, IGF-1, and IGFBP3 in the growth retardation group were lower than those in the non-growth retardation group. The AUC of GH-IGFs combined detection was higher than that of GH and IGFBP3 alone detection. GH < 9.27 μg/L and IGF-1 < 179.53 mmoL/L were risk factors for growth retardation in patients with bronchial asthma. ConclusionGH-IGFs-related parameters have diagnostic value for growth retardation in children, and decreased levels of GH and IGF-1 are risk factors for growth retardation in children." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0002" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abss0003" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abss0004" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0005" "titulo" => "Conclusion" ] ] ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "Equal contributions to this study." "identificador" => "fn1" ] ] "multimedia" => array:8 [ 0 => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1067 "Ancho" => 3167 "Tamanyo" => 125224 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0004" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "GH-IGFs-related parameters in bronchial asthma." ] ] 1 => array:8 [ "identificador" => "fig0002" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 840 "Ancho" => 3167 "Tamanyo" => 230623 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0005" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "GH-IGFs-related parameters in patients with different severity of bronchial asthma." ] ] 2 => array:8 [ "identificador" => "fig0003" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 712 "Ancho" => 3167 "Tamanyo" => 87655 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0006" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Correlation analysis between GH-IGFs-related parameters and severity of bronchial asthma." ] ] 3 => array:8 [ "identificador" => "fig0004" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1154 "Ancho" => 3167 "Tamanyo" => 130128 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0007" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "GH-IGFs-related parameters in patients with or without growth retardation." ] ] 4 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 3174 "Ancho" => 3167 "Tamanyo" => 312164 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0008" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "ROC curve analysis of GH-IGFs-related indicators in diagnosis of growth retardation in children with bronchial asthma. Note: Comparison between the two groups (*p < 0.05)." ] ] 5 => array:8 [ "identificador" => "tbl0001" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0001"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Items \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0002"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Bronchial asthma group(n=112) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0003"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Control group(n=50) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0004"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">χ2/t \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0005"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0006"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Gender \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0007"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0008"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0009"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0010"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0011"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0012"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">62 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0013"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0014"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.131 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0015"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.716 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0016"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0017"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0018"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0019"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0020"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0021"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0022"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">8.92 ± 1.17 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0023"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">8.76 ± 1.21 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0024"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.672 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0025"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.503 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0026"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Course of disease (days) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0027"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">10.52 ± 2.03 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0028"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">10.98 ± 2.15 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0029"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">1.1 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0030"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.274 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0031"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Maternal height (cm) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0032"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">161.29 ± 4.67 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0033"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">162.02 ± 4.73 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0034"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.777 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0035"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.439 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0036"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Paternal height (cm) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0037"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">172.85 ± 5.06 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0038"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">172.79 ± 5.11 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0039"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.059 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0040"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.953 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0041"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Family history of asthma \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0042"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0043"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0044"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0045"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.764 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3711648.png" ] ] ] ] "descripcion" => array:1 [ "en" => "General data between the bronchial asthma group and the control group." ] ] 6 => array:8 [ "identificador" => "tbl0002" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0002" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "Compared with combined." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0046"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Parameters \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0047"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Cut-off value \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0048"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">AUC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0049"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">SE \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0050"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">95%CI \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0051"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">GH \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0052"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">9.27 μg/L \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0053"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.811<a class="elsevierStyleCrossRef" href="#tb2fn1">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0054"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.049 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0055"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.715ཞ0.907 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0056"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">IGF-1 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0057"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">179.53 mmoL/L \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0058"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.905 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0059"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.028 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0060"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.850ཞ0.960 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0061"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">IGFBP3 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0062"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">8.12 mmoL/L \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0063"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.677<a class="elsevierStyleCrossRef" href="#tb2fn1">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0064"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.06 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0065"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.559ཞ0.795 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0066"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Combined \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0067"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0068"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.941 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0069"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.021 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0070"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.899∼0.982 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3711647.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tb2fn1" "etiqueta" => "a" "nota" => "p < 0.05." ] ] ] "descripcion" => array:1 [ "en" => "Diagnostic value analysis of GH-IGFs system related indexes in growth retardation." ] ] 7 => array:8 [ "identificador" => "tbl0003" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0003" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Assignment: GH (≥ 9.27 μg/L is 1, < 9.27 μg/L is 0); IGF-1 (≥ 179.53 mmol/L is 1, < 179.53 mmoL/L is 0); IGFBP3 (≥ 8.12 mmoL/L is 1, < 8.12 mmoL/L is 0)." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0071"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Parameters \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0072"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">β \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0073"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">SE \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0074"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">waldχ2 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0075"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">OR \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0076"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">95%CI \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0077"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0078"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">GH \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0079"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">−0.614 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0080"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.197 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0081"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">9.714 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0082"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.541 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0083"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.368ཞ0.796 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0084"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0085"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">IGF-1 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0086"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">−0.118 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0087"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.028 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0088"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">17.76 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0089"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.889 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0090"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.841ཞ0.939 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0091"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0092"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">IGFBP3 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0093"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">−0.228 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0094"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.227 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0095"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.009 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0096"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.796 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0097"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.510ཞ1.242 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0098"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.316 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0099"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Constant \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0100"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">2.35 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0101"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.513 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0102"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">20.985 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0103"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">10.486 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0104"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">3.836ཞ28.659 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0105"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3711649.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Logistic regression analysis of GH-IGFs-related indicators and growth retardation." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec1" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0001" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sanfu herbal patch applied at acupoints in patients with bronchial asthma: study protocol for a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "X Xie" 1 => "D Xu" 2 => "L Zhuang" 3 => "H Liu" 4 => "S Tan" 5 => "Y Lu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13063-020-04604-8" "Revista" => array:7 [ "tituloSerie" => "Trials" "fecha" => "2020" "volumen" => "21" "numero" => "1" "paginaInicial" => "684" "paginaFinal" => "689" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32727619" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0002" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correction: Targeting the HIF-1α-IGFBP2 axis therapeutically reduces IGF1-AKT signaling and blocks the growth and metastasis of relapsed anaplastic Wilms tumor" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y Liu" 1 => "MV Nelson" 2 => "C Bailey" 3 => "P Zhang" 4 => "P Zheng" 5 => "JS Dome" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41388-021-02042-7" "Revista" => array:7 [ "tituloSerie" => "Oncogene" "fecha" => "2022" "volumen" => "41" "numero" => "9" "paginaInicial" => "1383" "paginaFinal" => "1405" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35046533" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0003" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "mRNA expression of toll-like receptors 3, 7, 8, and 9 in the nasopharyngeal epithelial cells of coronavirus disease 2019 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Z Bagheri-Hosseinabadi" 1 => "E Rezazadeh Zarandi" 2 => "M Mirabzadeh" 3 => "A Amiri" 4 => "M Abbasifard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12879-022-07437-9" "Revista" => array:7 [ "tituloSerie" => "BMC Infect Dis" "fecha" => "2022" "volumen" => "22" "numero" => "1" "paginaInicial" => "448" "paginaFinal" => "453" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35538443" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0004" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "RH Salama" 1 => "Z Rasheed" 2 => "AA Ahmed" 3 => "GA Bin Saif" 4 => "MM Elkholy" 5 => "AEA 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Li Lia,1, Lihua Qiub,1, Junchao Xiaa, Yichun Xiaoa, Li Zhaoc, Haiyan Wangc,

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wanghaiyan8009@outlook.com

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a Department of Pediatrics, Ganzhou People's Hospital, Ganzhou City, Jiangxi Province, China

b Department of Pediatrics, Huaian Hospital of Huaian City, Huaian City, Jiangsu Province, China

c Department of Pediatrics, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang City, Hebei Province, China

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0008">Introduction</span><p id="para0012" class="elsevierStylePara elsevierViewall">Pediatric bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation&#46; At the onset of the disease&#44; sporadic or diffuse wheezing rale in the expiratory phase can be heard in both lungs&#44; and patients are often accompanied by variable expiratory airflow limitation&#44; recurrent wheezing&#44; shortness of breath&#44; chest tightness&#44; or cough&#46; Bronchial asthma is a chronic inflammation involving a variety of inflammatory cells&#44; which can cause airway damage&#44; and then lead to airway smooth muscle thickening&#46;<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> Insulin-like Growth Factor-1 &#40;IGF-1&#41; is involved in the repair process of airway epithelium and alveolar injury&#46;<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> It has been reported in the past that the growth of airway epithelial cells can be promoted by regulating IGF-1 concentration&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a> IGFs are a class of insulin-like peptides that promote cell differentiation and proliferation and are the main factors in the Growth Hormone &#40;GH&#41; - Insulin-like Growth Factors &#40;GH-IGFs&#41;&#46; There is a feedback regulatory system between IGF-1 and GH&#46; GH can promote the synthesis and release of IGF-1&#44; while IGF-1 can increase the hypothalamic somatostatin secretion and inhibit the release of GH or directly inhibit the synthesis of GH by pituitary GH cells&#44; thereby reducing GH levels&#46;<a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> GH-IGFs is related to the growth of children&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> Bone growth and development are mainly regulated by IGF-1&#8242;s endocrine function&#46; GH can act on target cells to directly promote cell differentiation and proliferation and stimulate the production of IGF-1 in peripheral tissues&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a> However&#44; there is no clear report on its relationship with the growth of children with bronchial asthma&#46; Therefore&#44; the purpose of this study was to explore the relationship between GH-IGFs and growth retardation in children with bronchial asthma to provide a reference for the assessment of the disease and the growth of children&#46;</p></span><span id="sec0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0009">Data and methods</span><span id="sec0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0010">Clinical data</span><p id="para0013" class="elsevierStylePara elsevierViewall">112 children with bronchial asthma &#40;bronchial asthma group&#41; and 50 healthy children &#40;control group&#41; from January 2021 to January 2022 were studied&#44; showing no significant difference in clinical data between the two groups &#40;p &#62; 0&#46;05&#44; <a class="elsevierStyleCrossRef" href="#tbl0001">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0001"></elsevierMultimedia></span><span id="sec0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0011">Inclusion criteria</span><p id="para0014" class="elsevierStylePara elsevierViewall">&#9312; Meeting the diagnostic criteria for bronchial asthma&#59;<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a>&#59;</p><p id="para0015" class="elsevierStylePara elsevierViewall">&#9313; Age &#60; 14 years old&#59;</p><p id="para0016" class="elsevierStylePara elsevierViewall">&#9314; Complete clinical data&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0012">Exclusion criteria</span><p id="para0017" class="elsevierStylePara elsevierViewall">&#9312; Severe cardiac&#44; liver and renal dysfunction&#59;</p><p id="para0018" class="elsevierStylePara elsevierViewall">&#9313; Congenital diseases&#59;</p><p id="para0019" class="elsevierStylePara elsevierViewall">&#9314; Intrauterine growth retardation&#59;</p><p id="para0020" class="elsevierStylePara elsevierViewall">&#9315; Other lung diseases&#59;</p><p id="para0021" class="elsevierStylePara elsevierViewall">&#9316; Abnormal thyroid function&#59;</p><p id="para0022" class="elsevierStylePara elsevierViewall">&#9317; Intracranial tumor disease&#46;</p></span><span id="sec0006" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0013">Bronchial severity</span><p id="para0023" class="elsevierStylePara elsevierViewall">The bronchial asthma group was divided into grades 1&#44; 2&#44; 3 and 4 according to the Guideline for the diagnosis and optimal management of asthma in children&#46;</p></span><span id="sec0007" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0014">GH-IGFs-related parameter detection</span><p id="para0024" class="elsevierStylePara elsevierViewall">Centrifuge treatment was conducted on the KDC-1042 high-speed centrifuge &#40;Anhui Zhongke Zhongjia Scientific Instrument Co&#46;&#44; Ltd&#46;&#41; at 3000 r&#47;min for 10-min&#44; with the centrifuge radius of 15 cm&#46; Serum was separated to measure GH&#44; IGF-1&#44; and Insulin-like Growth Factor Binding Protein-3 &#40;IGFBP3&#41; on a Lab systems Dragou Wellscan K-3 microplate reader using enzyme-linked immunosorbent assay&#46;</p></span><span id="sec0008" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0015">Diagnostic criteria for growth retardation</span><p id="para0025" class="elsevierStylePara elsevierViewall">The physical standard of children with developmental delay is 30 &#37; lower than that of children in the same state&#46;<a class="elsevierStyleCrossRef" href="#bib0008"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0009" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0016">Outcome measures</span><p id="para9001" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="celist0002"><li class="elsevierStyleListItem" id="celistitem0007"><span class="elsevierStyleLabel">1&#41;</span><p id="para0026" class="elsevierStylePara elsevierViewall">GH-IGFs-related parameters were compared&#44; and the correlation between each parameter and the severity of bronchial asthma was analyzed&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0008"><span class="elsevierStyleLabel">2&#41;</span><p id="para0027" class="elsevierStylePara elsevierViewall">The bronchial asthma group was divided into the growth retardation group and non-growth retardation group according to the growth conditions&#44; and the diagnostic value of GH-IGFs related indicators for growth retardation and its relationship with growth retardation were analyzed&#46;</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0017">Statistical analysis</span><p id="para0028" class="elsevierStylePara elsevierViewall">Statistics were processed using SPSS22&#46;0 software&#46; Enumeration data &#40;&#37;&#41; were compared by &#967;<span class="elsevierStyleSup">2</span> test&#46; Measurement data &#40;x&#175; &#177; s&#41; after the normality test were compared by <span class="elsevierStyleItalic">t</span>-test or multivariate analysis of variance&#46; Spearman test was conducted to analyze the correlation between GH-IGFs and the severity of bronchial asthma&#46; ROC curve was plotted to analyze the diagnostic value of GH-IGFs in growth retardation&#46; Logistic regression was applied to analyze the relationship between GH-IGFs and growth retardation&#59; p &#60; 0&#46;05 meant that the difference was statistically significant&#46;</p></span></span><span id="sec0011" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0018">Results</span><span id="sec0012" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0019">GH-IGFs-related parameters</span><p id="para0029" class="elsevierStylePara elsevierViewall">GH&#44; IGF-1&#44; and IGFBP3 levels in the bronchial asthma group were lower than those in the control group &#40;p &#60; 0&#46;05&#44; <a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0001"></elsevierMultimedia></span><span id="sec0013" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0020">GH-IGFs-related parameters in patients with different severity of bronchial asthma</span><p id="para0030" class="elsevierStylePara elsevierViewall">GH&#44; IGF-1&#44; and IGFBP3 in patients with bronchial asthma showed a decreasing trend with the severity of the disease &#40;p &#60; 0&#46;05&#44; <a class="elsevierStyleCrossRef" href="#fig0002">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0002"></elsevierMultimedia></span><span id="sec0014" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0021">Correlation analysis of GH-IGFs-related parameters and severity of bronchial asthma</span><p id="para0031" class="elsevierStylePara elsevierViewall">A negative correlation was found between GH&#44; IGF-1&#44; and IGFBP3 levels and asthma severity &#40;p &#60; 0&#46;05&#44; <a class="elsevierStyleCrossRef" href="#fig0003">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0003"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0022">GH-IGFs-related parameters in patients with or without growth retardation</span><p id="para0032" class="elsevierStylePara elsevierViewall">GH&#44; IGF-1&#44; and IGFBP3 in the growth retardation group were lower than those in the non-growth retardation group &#40;p &#60; 0&#46;05&#44; <a class="elsevierStyleCrossRef" href="#fig0004">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0004"></elsevierMultimedia></span><span id="sec0016" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0023">Diagnostic value of GH-IGFs-related indicators in growth retardation</span><p id="para0033" class="elsevierStylePara elsevierViewall">The AUC of the combined detection of GH-IGFs-related indicators in the diagnosis of growth retardation was greater than that of GH and IGFBP3 alone &#40;p &#60; 0&#46;05&#44; <a class="elsevierStyleCrossRef" href="#tbl0002">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0002"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0017" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0024">Logistic regression analysis of GH-IGFs-related indicators and growth retardation</span><p id="para0034" class="elsevierStylePara elsevierViewall">GH &#60;9&#46;27 &#956;g&#47;L and IGF-1 &#60; 179&#46;53 mmoL&#47;L were risk factors for growth retardation in patients with bronchial asthma &#40;p &#60; 0&#46;05&#44; <a class="elsevierStyleCrossRef" href="#tbl0003">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0003"></elsevierMultimedia></span></span><span id="sec0018" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0025">Discussion</span><p id="para0035" class="elsevierStylePara elsevierViewall">Children&#39;s bronchial asthma is a respiratory disease that seriously affects children&#39;s physical and mental health&#46; As this chronic inflammatory response persists&#44; the airway is in a state of hyper-responsiveness&#44; and the symptoms will occur repeatedly upon stimuli exposure&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">9</span></a> Inflammatory cells are involved in bronchial asthma and cause airway injury and airway smooth muscle thickening&#46;<a class="elsevierStyleCrossRef" href="#bib0011"><span class="elsevierStyleSup">10</span></a> IGF-1 is involved in the repair process of airway epithelium and alveolar injury&#44;<a class="elsevierStyleCrossRef" href="#bib0012"><span class="elsevierStyleSup">11</span></a> and regulating IGF-1 concentration can promote the growth of airway epithelial cells&#44; suggesting that IGF-1 is involved in the process of airway epithelial cell proliferation&#46;<a class="elsevierStyleCrossRef" href="#bib0013"><span class="elsevierStyleSup">12</span></a> Blood IGF-1 can participate in the negative feedback regulation of GH by inhibiting GH expression and transcription in the pituitary gland and stimulating GH release in the hypothalamus&#46; GH can directly act on osteoblasts to promote cell proliferation and increase type I collagen synthesis&#46; IGF-1 can stimulate the repair of osteoblast progenitor cells&#44; and osteoblast differentiation&#44; and induce bone collagen synthesis&#46; IGFBP3 is a polypeptide containing multiple amino acids&#44; which is less responsive to GH than IGF-1&#46; Exogenous GH can increase IGF-1 and IGFBP3 in blood&#44; and IGF-1 infusion can decrease GH concentration&#44; suggesting that the amount of GH in blood is closely related to that of IGF-1&#46;<a class="elsevierStyleCrossRef" href="#bib0014"><span class="elsevierStyleSup">13</span></a><a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">14</span></a> In this study&#44; GH&#44; IGF-1&#44; and IGFBP3 in the bronchial asthma group were lower than those in the control group&#44; indicating the abnormal expression of GH-IGFs in children with bronchial asthma&#44; which may be related to the involvement of IGF-1 in the repair of airway epithelium and alveolar injury&#46; In addition&#44; GH&#44; IGF-1&#44; and IGFBP3 were negatively correlated with the severity of bronchial asthma&#44; suggesting that the severity of the disease could be assessed by detecting GH-IGFs-related parameters&#46;</p><p id="para0036" class="elsevierStylePara elsevierViewall">Children&#39;s is jointly regulated by the GH-IGFs&#46; GH is secreted by adenohypophysis and regulated by growth hormone releasing hormone&#46; Its growth-promoting effect is mainly mediated by IGF-1 and IGF-2&#44; and IGFs secretion depends on GH&#46; Under normal circumstances&#44; IGF-1 level is mainly regulated by GH&#44; and serum IGF-1 level can reflect the synthesis and release of GH&#46; In blood circulation&#44; IGFBP3 can combine with IGF-1 to form a complex&#44; prolong the half-life of IGF-1 in blood vessels&#44; and increase IGF-1 levels in blood&#46; IGFBP3 can be degraded by IGFBP3 protease&#44; and after degradation&#44; the affinity between IGFBP3 and IGF-1 decreases&#44; thereby releasing more free IGF-1 and enhancing the growth-promoting function of IGF-1&#46;<a class="elsevierStyleCrossRef" href="#bib0016"><span class="elsevierStyleSup">15</span></a><a class="elsevierStyleCrossRef" href="#bib0017"><span class="elsevierStyleSup">16</span></a></p><p id="para0037" class="elsevierStylePara elsevierViewall">In children&#44; GH-IGFs regulate Children&#39;s and metabolism&#44; and the growth-promoting effect of GH is mainly mediated by IGF-1 secreted by the liver&#46;<a class="elsevierStyleCrossRef" href="#bib0018"><span class="elsevierStyleSup">17</span></a><a class="elsevierStyleCrossRef" href="#bib0019"><span class="elsevierStyleSup">18</span></a> GH binding to GHR in target cells triggers IGFs expression and secretion&#44; wherein IGF-1 enters the tissues by binding to IGFBP&#44; and the growth-promoting and anabolic effects of IGF-1 are triggered by IGF-I binding to IGF-IR in target organs&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">19</span></a><a class="elsevierStyleCrossRef" href="#bib0021"><span class="elsevierStyleSup">20</span></a> In this study&#44; GH&#44; IGF-1&#44; and IGFBP3 in the growth retardation group were lower than those in the non-growth retardation group&#46; The AUC of the combined detection of GH-IGFs-related indicators in the diagnosis of growth retardation was greater than that of GH and IGFBP3 alone&#46; In addition&#44; GH &#60; 9&#46;27 &#956;g&#47;L and IGF-1 &#60; 179&#46;53 mmoL&#47;L were risk factors for growth retardation in children with bronchial asthma&#44; indicating that decreased GH and IGF-1 could lead to growth retardation in children&#46; The reason is that GH can stimulate peripheral tissues&#44; especially the liver&#44; to secrete IGF-1&#44; which can promote organ development and activate bone anabolism&#46; The effect of GH on growth is mediated by IGF-1&#44; so abnormal IGF-1 can also affect Children&#46;<a class="elsevierStyleCrossRefs" href="#bib0022"><span class="elsevierStyleSup">21&#8211;23</span></a></p><p id="para0038" class="elsevierStylePara elsevierViewall">In summary&#44; abnormal GH-IGFs-related indicators exist in children with bronchial asthma&#44; and GH-IGFs-related indicators in children are of diagnostic value for growth and development&#44; and decreased levels of GH and IGF-1 are risk factors for growth retardation in children&#46;</p></span><span id="sec0019" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0026">Availability of data and materials</span><p id="para0039" class="elsevierStylePara elsevierViewall">The datasets used and&#47;or analyzed during the present study are available from the corresponding author upon reasonable request&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0027">Ethics approval</span><p id="para0040" class="elsevierStylePara elsevierViewall">The present study was approved by the Ethics Committee of Ganzhou People&#39;s Hospital and written informed consent was provided by all patients prior to the study start&#46; All procedures were performed in accordance with the ethical standards of the Institutional Review Board and The Declaration of Helsinki&#44; and its later amendments or comparable ethical standards&#46;</p></span><span id="sec0021" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0028">Authors&#8217; contributions</span><p id="para0041" class="elsevierStylePara elsevierViewall">Li Li and Lihua Qiu designed the research study&#46; Junchao Xia and Yichun Xiao performed the research&#46; Li Zhao and Haiyan Wang provided help and advice on the experiments&#46; Li Li&#44; Lihua Qiu and Haiyan Wang analyzed the data&#46; Li Li and Lihua Qiu wrote the manuscript&#46; Haiyan Wang reviewed and edited the manuscript&#46; All authors contributed to editorial changes in the manuscript&#46; All authors read and approved the final manuscript&#46;</p></span><span id="sec0022" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0029">Funding</span><p id="para0042" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleGrantSponsor" id="gs0001">Jiangxi Provincial Health and Family Planning Commission Science and Technology Program</span> &#40;<span class="elsevierStyleGrantNumber" refid="gs0001">SKJP220203187</span>&#41;&#46;</p></span></span>"
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              "titulo" => "Correlation analysis of GH-IGFs-related parameters and severity of bronchial asthma"
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      "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><p id="spara011" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001"><span class="elsevierStyleLabel">&#8226;</span><p id="para0002" class="elsevierStylePara elsevierViewall">GH-IGFs-related parameters&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0002"><span class="elsevierStyleLabel">&#8226;</span><p id="para0003" class="elsevierStylePara elsevierViewall">GH-IGFs-related parameters in patients with different severity of bronchial asthma&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0003"><span class="elsevierStyleLabel">&#8226;</span><p id="para0004" class="elsevierStylePara elsevierViewall">Correlation analysis of GH-IGFs-related parameters and severity of bronchial asthma&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0004"><span class="elsevierStyleLabel">&#8226;</span><p id="para0005" class="elsevierStylePara elsevierViewall">GH-IGFs-related parameters in patients with or without growth retardation&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0005"><span class="elsevierStyleLabel">&#8226;</span><p id="para0006" class="elsevierStylePara elsevierViewall">Diagnostic value of GH-IGFs-related indicators in growth retardation&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0006"><span class="elsevierStyleLabel">&#8226;</span><p id="para0007" class="elsevierStylePara elsevierViewall">Logistic regression analysis of GH-IGFs-related indicators and growth retardation&#46;</p></li></ul></p></span>"
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        "resumen" => "<span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Objective</span><p id="spara012" class="elsevierStyleSimplePara elsevierViewall">To explore the relationship between Growth Hormone Insulin-like Growth Factors &#40;GH-IGFs&#41; and growth retardation in children with bronchial asthma&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Methods</span><p id="spara013" class="elsevierStyleSimplePara elsevierViewall">112 children with bronchial asthma and 50 healthy children were studied&#46; Serum GH&#44; IGF-1&#44; and Insulin-like Growth Factor Binding Protein 3 &#40;IGFBP3&#41; were assessed by ELISA&#46; GH-IGFs-related parameters were compared&#44; and the correlation between the parameters and bronchial asthma severity was analyzed&#46; The bronchial asthma group was divided into the growth retardation group and non-growth retardation group to analyze the diagnostic value of GH-IGFs in growth retardation and the relationship between GH-IGFs and growth retardation&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0005">Results</span><p id="spara014" class="elsevierStyleSimplePara elsevierViewall">GH&#44; IGF-1&#44; and IGFBP3 in the bronchial asthma group were lower&#46; GH&#44; IGF-1&#44; and IGFBP3 levels were decreased with the severity of bronchial asthma&#46; GH&#44; IGF-1&#44; and IGFBP3 in the growth retardation group were lower than those in the non-growth retardation group&#46; The AUC of GH-IGFs combined detection was higher than that of GH and IGFBP3 alone detection&#46; GH &#60; 9&#46;27 &#956;g&#47;L and IGF-1 &#60; 179&#46;53 mmoL&#47;L were risk factors for growth retardation in patients with bronchial asthma&#46;</p></span> <span id="abss0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0006">Conclusion</span><p id="spara015" class="elsevierStyleSimplePara elsevierViewall">GH-IGFs-related parameters have diagnostic value for growth retardation in children&#44; and decreased levels of GH and IGF-1 are risk factors for growth retardation in children&#46;</p></span>"
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                  \t\t\t\t  " align="" valign="top">Course of disease &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0027"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">10&#46;52 &#177; 2&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0028"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">10&#46;98 &#177; 2&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0029"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0030"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;274&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0031"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">Maternal height &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0032"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">161&#46;29 &#177; 4&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0033"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">162&#46;02 &#177; 4&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0034"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;777&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0035"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;439&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0036"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">Paternal height &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0037"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">172&#46;85 &#177; 5&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0038"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">172&#46;79 &#177; 5&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0039"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;059&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0040"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;953&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0041"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">Family history of asthma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0042"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0043"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0044"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0045"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;764&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab3711648.png"
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          "en" => "<p id="spara006" class="elsevierStyleSimplePara elsevierViewall">General data between the bronchial asthma group and the control group&#46;</p>"
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      6 => array:8 [
        "identificador" => "tbl0002"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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          0 => array:3 [
            "identificador" => "alt0002"
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        "tabla" => array:3 [
          "leyenda" => "<p id="spara008" class="elsevierStyleSimplePara elsevierViewall">Compared with combined&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0046"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Parameters</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0047"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Cut-off value</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0048"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">AUC</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0049"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">SE</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0050"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">95</span><span class="elsevierStyleBold">&#37;CI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0051"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">GH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0052"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">9&#46;27 &#956;g&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0053"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;811<a class="elsevierStyleCrossRef" href="#tb2fn1"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0054"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0055"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;715&#3934;0&#46;907&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0056"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">IGF-1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0057"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">179&#46;53 mmoL&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0058"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;905&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0059"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;028&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0060"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;850&#3934;0&#46;960&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0061"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">IGFBP3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0062"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">8&#46;12 mmoL&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0063"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;677<a class="elsevierStyleCrossRef" href="#tb2fn1"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0064"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0065"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;559&#3934;0&#46;795&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0066"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">Combined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0067"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0068"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;941&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0069"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0070"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;899&#8764;0&#46;982&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "nota" => "<p class="elsevierStyleNotepara" id="notep0003">p &#60; 0&#46;05&#46;</p>"
            ]
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara007" class="elsevierStyleSimplePara elsevierViewall">Diagnostic value analysis of GH-IGFs system related indexes in growth retardation&#46;</p>"
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      ]
      7 => array:8 [
        "identificador" => "tbl0003"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
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            "identificador" => "alt0003"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spara010" class="elsevierStyleSimplePara elsevierViewall">Assignment&#58; GH &#40;&#8805; 9&#46;27 &#956;g&#47;L is 1&#44; &#60; 9&#46;27 &#956;g&#47;L is 0&#41;&#59; IGF-1 &#40;&#8805; 179&#46;53 mmol&#47;L is 1&#44; &#60; 179&#46;53 mmoL&#47;L is 0&#41;&#59; IGFBP3 &#40;&#8805; 8&#46;12 mmoL&#47;L is 1&#44; &#60; 8&#46;12 mmoL&#47;L is 0&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0071"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Parameters</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0072"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">&#946;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0073"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">SE</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0074"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">wald&#967;<span class="elsevierStyleSup">2</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0075"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">OR</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0076"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">95</span><span class="elsevierStyleBold">&#37;CI</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0077"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0078"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">GH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0079"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#8722;0&#46;614&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0080"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;197&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0081"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">9&#46;714&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0082"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;541&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0083"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;368&#3934;0&#46;796&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0084"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0085"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">IGF-1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0086"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#8722;0&#46;118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0087"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;028&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0088"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">17&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0089"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;889&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0090"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;841&#3934;0&#46;939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0091"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0092"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">IGFBP3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0093"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#8722;0&#46;228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0094"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;227&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0095"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0096"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;796&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0097"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;510&#3934;1&#46;242&nbsp;\t\t\t\t\t\t\n
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Article information

ISSN: 18075932
Original language: English

DOI:10.1016/j.clinsp.2024.100385

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	7	0	7
2024 October	42	22	64
2024 September	42	22	64
2024 August	66	13	79
2024 July	61	34	95
2024 June	53	17	70
2024 May	68	50	118

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