metricas
covid
Buscar en
Clinics
Toda la web
Inicio Clinics Homeopathy is not placebo effect: proof of the scientific evidence for homeopath...
Journal Information

Statistics

Follow this link to access the full text of the article

Editorials
Homeopathy is not placebo effect: proof of the scientific evidence for homeopathy in open access trilingual e-book
Marcus Zulian Teixeira
Departamento de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil
Read
897
Times
was read the article
251
Total PDF
646
Total HTML
Share statistics
 array:22 [
  "pii" => "S1807593224001339"
  "issn" => "18075932"
  "doi" => "10.1016/j.clinsp.2024.100456"
  "estado" => "S250"
  "fechaPublicacion" => "2024-01-01"
  "aid" => "100456"
  "copyright" => "HCFMUSP"
  "copyrightAnyo" => "2024"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "edi"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:17 [
    "pii" => "S1807593224001595"
    "issn" => "18075932"
    "doi" => "10.1016/j.clinsp.2024.100482"
    "estado" => "S250"
    "fechaPublicacion" => "2024-01-01"
    "aid" => "100482"
    "copyright" => "HCFMUSP"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "edi"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorials</span>"
      "titulo" => "Resource management strategies for prioritizing non-scheduled surgical procedures in a tertiary public hospital"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0001"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1735
              "Ancho" => 3333
              "Tamanyo" => 539990
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "alt0001"
              "detalle" => "Fig "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Shared panel with the list of patients waiting for an operating room&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Marcelo Cristiano Rocha, Rafaela Alkmin da Costa, Edivaldo Massazo Utiyama"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Marcelo Cristiano"
              "apellidos" => "Rocha"
            ]
            1 => array:2 [
              "nombre" => "Rafaela Alkmin da"
              "apellidos" => "Costa"
            ]
            2 => array:2 [
              "nombre" => "Edivaldo Massazo"
              "apellidos" => "Utiyama"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593224001595?idApp=UINPBA00004N"
    "url" => "/18075932/000000790000000C/v123_202411010523/S1807593224001595/v123_202411010523/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "S1807593224001200"
    "issn" => "18075932"
    "doi" => "10.1016/j.clinsp.2024.100443"
    "estado" => "S250"
    "fechaPublicacion" => "2024-01-01"
    "aid" => "100443"
    "copyright" => "HCFMUSP"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "edi"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorials</span>"
      "titulo" => "Physician leadership in private acquisitions&#58; Styles for all situations"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Max S&#46; Mano, Fadil &#199;itaku"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Max S&#46;"
              "apellidos" => "Mano"
            ]
            1 => array:2 [
              "nombre" => "Fadil"
              "apellidos" => "&#199;itaku"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593224001200?idApp=UINPBA00004N"
    "url" => "/18075932/000000790000000C/v123_202411010523/S1807593224001200/v123_202411010523/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorials</span>"
    "titulo" => "Homeopathy is not placebo effect&#58; proof of the scientific evidence for homeopathy in open access trilingual e-book"
    "tieneTextoCompleto" => true
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Marcus Zulian Teixeira"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "Marcus Zulian"
            "apellidos" => "Teixeira"
            "email" => array:2 [
              0 => "marcus@homeozulian.med.br"
              1 => "mzulian@alumni.usp.br"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Psiquiatria&#44; Faculdade de Medicina&#44; Universidade de S&#227;o Paulo&#44; S&#227;o Paulo&#44; SP&#44; Brazil"
            "identificador" => "aff0001"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0006" class="elsevierStylePara elsevierViewall">Homeopathy was founded in 1796 by the German physician Samuel Hahnemann&#46; It is an integrative medical practice that uses a clinical approach based on four heterodox and complementary scientific assumptions &#40;principle of therapeutic similarity&#44; homeopathic pathogenetic experimentation&#44; use of individualized medicines and in dynamized doses&#41;&#44; with the aim to awaken a healing response from the body against its own disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a></p><p id="para0007" class="elsevierStylePara elsevierViewall">In addition to these scientific premises&#44; the homeopathic epistemological model also uses vitalist and miasmatic philosophical conceptions to expand understanding of the complex process of human illness&#44; attributing to the imbalance of the organic vital force and the manifestation of chronic miasms the primary and fundamental causes of the diseases&#44; respectively&#46; Supported by conceptual&#44; functional and experimental correlations&#44; this homeopathic vital force would find its representation or biological substrate in the genome &#40;exome plus epigenome&#41;&#44; while the chronic miasms would be biologically represented by the disease-promoting epigenetic alterations&#46;<a class="elsevierStyleCrossRefs" href="#bib0002"><span class="elsevierStyleSup">2&#8211;5</span></a></p><p id="para0008" class="elsevierStylePara elsevierViewall">Because it is based on epistemological premises that are different from conventional medical practice&#44; homeopathy is generally poorly understood&#44; suffering criticism from prejudiced individuals who systematically deny homeopathic principles and any scientific evidence that proves them&#46; In reality&#44; they are pseudoskeptics masquerading as pseudoscientists&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a></p><p id="para0009" class="elsevierStylePara elsevierViewall">In order to enlighten everyone and demystify culturally ingrained pseudoskeptical fallacies &#40;such as&#44; &#8220;there is no scientific evidence for homeopathy&#8221; and &#8220;homeopathy is placebo effect&#8221;&#41;&#44; the Technical Chamber for Homeopathy of the Regional Medical Council of the State of S&#227;o Paulo &#40;Cremesp&#41; produced the Special Dossier &#8220;Scientific Evidence for Homeopathy&#8221; in 2017&#44; available in open access trilingual editions &#40;Portuguese&#44; English and Spanish&#41; in the <span class="elsevierStyleItalic">Revista de Homeopatia</span> &#40;S&#227;o Paulo&#41; and <span class="elsevierStyleItalic">La Homeopat&#237;a de M&#233;xico</span> scientific journals&#46;<a class="elsevierStyleCrossRefs" href="#bib0007"><span class="elsevierStyleSup">7-9</span></a></p><p id="para0010" class="elsevierStylePara elsevierViewall">This Dossier is composed of nine narrative research reviews in several medical science fields &#40;historical&#44; social&#44; medical education&#44; pharmacological&#44; basic&#44; clinical&#44; patient safety and pathogenetic experimentation&#41;&#44; encompassing hundreds of scientific articles describing experimental and clinical studies&#46; It seeks to highlight the state of the art of homeopathic research&#46;<a class="elsevierStyleCrossRefs" href="#bib0007"><span class="elsevierStyleSup">7-9</span></a></p><p id="para0011" class="elsevierStylePara elsevierViewall">Then&#44; in order to expand and update this scientific evidence for homeopathy&#44; the authors published the electronic book &#40;e-book&#44; PDF editing&#41; in Portuguese &#8220;<span class="elsevierStyleItalic">Homeopatia n&#227;o &#233; efeito placebo&#58; comprova&#231;&#227;o das evid&#234;ncias cient&#237;ficas da homeopatia</span>&#8221; in 2023&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">10</span></a> which was translated into English and Spanish in 2024 <span class="elsevierStyleItalic">&#40;&#8220;Homeopathy is not placebo effect&#8221;&#58; proof of scientific evidence for homeopathy &#47; &#8220;La homeopat&#237;a no es efecto placebo&#8221;&#58; comprobaci&#243;n de las evidencias cient&#237;ficas en homeopat&#237;a</span><span class="elsevierStyleItalic">&#41;</span>&#44; being made available in open access editions in the Virtual Health Library &#40;VHL-LILACS-BIREME&#41;<a class="elsevierStyleCrossRefs" href="#bib0011"><span class="elsevierStyleSup">11-13</span></a> and in the USP Open Books Portal&#44;<a class="elsevierStyleCrossRef" href="#bib0013"><span class="elsevierStyleSup">14</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0014"><span class="elsevierStyleSup">15</span></a> increasing knowledge of the area in 13 interactive chapters&#46;</p><p id="para0012" class="elsevierStylePara elsevierViewall">In turn&#44; this trilingual book series were also made available in EPUB editing &#40;Kindle&#44; Amazon&#41;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">16-18</span></a> to expand the dissemination scope of the material&#44; and we are inviting homeopaths from other countries to collaborate in translating it into other languages&#46;</p><p id="para0013" class="elsevierStylePara elsevierViewall">Starting the work&#44; the chapter &#8220;Homeopathy&#8221; discusses the epistemological premises of the homeopathic model &#40;principle of therapeutic similitude&#44; homeopathic pathogenetic experimentation&#44; use of individualized medicines and in dynamized doses&#41;<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> in detail&#44; describing its evidence in general and providing the reader with an overview of treatment and clinical practice in homeopathy&#46;</p><p id="para0014" class="elsevierStylePara elsevierViewall">Then in the chapter &#8220;Clinical epidemiology in homeopathy&#8221;&#44; the principles of homeopathic clinical epidemiology are addressed after a review of the principles of classical clinical epidemiology and the types of epidemiological studies used to evaluate the efficacy and effectiveness of conventional treatments&#44; as well as the types of epidemiological studies in homeopathy&#46; It is worth highlighting that the epistemological premise of &#8220;individualization of homeopathic treatment in view of the symptomatic totality characteristic of the patient-disease binomial&#8221; is a <span class="elsevierStyleItalic">sine qua non</span> condition for dynamized homeopathic medicine &#40;ultra-diluted and with infinitesimal pathogenetic power&#41; to be able to awaken a curative response&#46;<a class="elsevierStyleCrossRef" href="#bib0017"><span class="elsevierStyleSup">19</span></a></p><p id="para0015" class="elsevierStylePara elsevierViewall">Next&#44; in addition to general databases &#40;LILACS and PubMed&#41;&#44; several specific homeopathic databases are described in the chapter &#8220;Overview of homeopathy research &#8211; Databases&#8221;&#59; these databases group together a wide range of homeopathic studies indexed in the areas of basic and clinical research&#44; from experimental studies in biological and physicochemical models &#40;Homeopathy Basic Research Experiments database&#44; HomVetCR database and PROVINGS&#46;INFO database&#41; through to epidemiological clinical studies of all types &#40;Clinical Outcome Research in Homeopathy&#44; Homeopathic Intervention Studies and CAM-QUEST databases&#41;&#46;</p><p id="para0016" class="elsevierStylePara elsevierViewall">The principle of similitude &#40;similarity&#41; is approached according to the homeopathic model and modern pharmacology in the chapter &#8220;Pharmacological basis of the principle of similitude&#8221;&#44; describing hundreds of experimental and clinical studies that support the curative response of homeopathic treatment &#40;vital reaction or therapeutic similarity&#41; in accordance with manifestations of the rebound effect of modern drugs &#40;paradoxical reaction of the organism&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0018"><span class="elsevierStyleSup">10-22</span></a> Furthermore&#44; it describes the proposal to use modern drugs according to the principle of therapeutic similitude&#44; using the rebound effect of drugs curatively&#46;<a class="elsevierStyleCrossRefs" href="#bib0021"><span class="elsevierStyleSup">23-25</span></a></p><p id="para0017" class="elsevierStylePara elsevierViewall">In the field of basic research in homeopathy&#44; the chapter &#8220;Experimental studies in biological models &#40;<span class="elsevierStyleItalic">in vitro</span>&#44; plants and animals&#41;&#8221; describes hundreds of experimental studies in cells&#44; plants and animals that demonstrate the superiority of homeopathic medicine over control groups&#44; highlighting that &#8220;homeopathy is not placebo effect&#8221; in systematic reviews and meta-analyses&#46;<a class="elsevierStyleCrossRefs" href="#bib0024"><span class="elsevierStyleSup">26-28</span></a></p><p id="para0018" class="elsevierStylePara elsevierViewall">In the field of clinical research in homeopathy&#44; the chapter &#8220;Randomized Controlled Clinical Trials &#40;RCTs&#41;&#8221; describes dozens of randomized&#44; double-blind and placebo-controlled clinical trials &#40;level of evidence 1B&#41; of good methodological quality which demonstrate the effectiveness of the homeopathic treatment versus placebo&#46; Four chapters address systematic reviews of RCTs&#44; global &#40;any clinical indication&#41; and specific &#40;specific clinical indication&#41; with and without meta-analyses&#44; increasing the level of evidence &#40;1A&#41; of the clinical effectiveness of homeopathy&#46;</p><p id="para0019" class="elsevierStylePara elsevierViewall">In the chapter &#8220;Systematic reviews and global reports with positive results of homeopathy compared to placebo&#8221;&#44; five global systematic reviews of RCTs with meta-analyses are described which demonstrate the superiority of homeopathic treatment over placebo&#46;<a class="elsevierStyleCrossRefs" href="#bib0027"><span class="elsevierStyleSup">29-33</span></a> On the other hand&#44; two global systematic reviews of RCTs&#44; one with meta-analysis and the other without&#44; are described in the chapter &#8220;Systematic reviews and global reports with negative results of homeopathy compared to placebo &#40;Methodological flaws&#41;&#8221;&#46; These presented negative results of homeopathy compared to placebo&#44;<a class="elsevierStyleCrossRef" href="#bib0032"><span class="elsevierStyleSup">34</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0033"><span class="elsevierStyleSup">35</span></a> however numerous biases and methodological flaws in the studies are evidenced&#44; as demonstrated in several post-hoc analyses published later&#46;</p><p id="para0020" class="elsevierStylePara elsevierViewall">Confirming these post-hoc analyses&#44; a systematic review of global systematic reviews of RCTs with meta-analyses described previously was published in 2023&#44; demonstrating that &#8220;global systematic reviews of homeopathic RCTs with meta-analyses reveal significant positive effects of homeopathy compared to placebo&#8221;&#44; and that &#8220;there was no support for the alternative hypothesis of no outcome difference between homeopathy and placebo&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0034"><span class="elsevierStyleSup">36</span></a></p><p id="para0021" class="elsevierStylePara elsevierViewall">Specific systematic reviews are described in the chapter &#8220;Systematic reviews for specific clinical conditions&#8221;&#44; which demonstrated the superiority of homeopathy over placebo in several clinical conditions&#58; with meta-analyses &#40;allergic rhinitis&#44; acute childhood diarrhea&#44; postoperative ileus and attention deficit disorder with hyperactivity&#41; and without meta-analyses &#40;acute otitis media&#44; postoperative inflammation&#44; psychiatric disorders and rheumatic diseases&#41;&#46;</p><p id="para0022" class="elsevierStylePara elsevierViewall">Then in the chapter &#8220;Observational studies&#8221;&#44; analytical observational studies &#40;level of evidence 2B&#41; were mainly addressed&#44; describing robust cohort studies that presented important information about the effectiveness and cost-effectiveness of homeopathic treatment in thousands of patients in the long term and in various clinical conditions&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">37-40</span></a></p><p id="para0023" class="elsevierStylePara elsevierViewall">Concluding the book&#44; the chapter &#8220;Pseudoskeptical and pseudoscientific strategies used in attacks on homeopathy&#8221; discusses pseudoskepticism and pseudoscience&#44; describing the tell-tale signs of pseudoskepticism &#40;bogus skepticism or pathological skepticism&#41; in detail&#44; which is a topic of fundamental importance for unmasking pseudoskeptics and pseudoscientists who systematically deny the vast amount of scientific evidence for homeopathy cited throughout the work&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a></p><p id="para0024" class="elsevierStylePara elsevierViewall">Thus&#44; despite the difficulties and limitations that exist in developing research in homeopathy&#44; whether due to methodological aspects or the lack of institutional and financial support&#44; the significant set of experimental and clinical studies described in the book is indisputable proof that &#8220;there is scientific evidence for homeopathy&#8221; and that &#8220;homeopathy is not placebo effect&#8221;&#44; contrary to the falsely disseminated prejudice&#46; However&#44; new studies must continue to be developed to improve clinical practice and elucidate peculiar aspects of the homeopathic paradigm&#46;</p><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Funding</span><p id="para0025" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:3 [
          "identificador" => "xres2291092"
          "titulo" => "Highlights"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abss0001"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "sec0001"
          "titulo" => "Funding"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2024-04-27"
    "fechaAceptado" => "2024-07-12"
    "tieneResumen" => true
    "highlights" => array:2 [
      "titulo" => "Highlights"
      "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><p id="spara001" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001"><span class="elsevierStyleLabel">&#8226;</span><p id="para0001" class="elsevierStylePara elsevierViewall">Homeopathy is based on four heterodox and complementary scientific assumptions&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0002"><span class="elsevierStyleLabel">&#8226;</span><p id="para0002" class="elsevierStylePara elsevierViewall">Pseudoskeptics deny these assumptions and any scientific evidence that proves them&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0003"><span class="elsevierStyleLabel">&#8226;</span><p id="para0003" class="elsevierStylePara elsevierViewall">The e-book proves the scientific evidence for homeopathy&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0004"><span class="elsevierStyleLabel">&#8226;</span><p id="para0004" class="elsevierStylePara elsevierViewall">The e-book describes hundreds of experimental and clinical studies in homeopathy&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0005"><span class="elsevierStyleLabel">&#8226;</span><p id="para0005" class="elsevierStylePara elsevierViewall">The e-book demystifies the fallacy that &#8220;homeopathy is placebo effect&#8221;&#46;</p></li></ul></p></span>"
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibs1ec1"
          "bibliografiaReferencia" => array:40 [
            0 => array:3 [
              "identificador" => "bib0001"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scientific evidence of the homeopathic epistemological model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J High Dilution Res"
                        "fecha" => "2011"
                        "volumen" => "10"
                        "numero" => "34"
                        "paginaInicial" => "46"
                        "paginaFinal" => "64"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0002"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between vitalism and genetics according to the paradigm of complexity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0039-1692162"
                      "Revista" => array:7 [
                        "tituloSerie" => "Homeopathy"
                        "fecha" => "2020"
                        "volumen" => "109"
                        "numero" => "1"
                        "paginaInicial" => "30"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31319421"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0003"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isopathic use of auto-sarcode of DNA as anti-miasmatic homeopathic medicine and modulator of gene expression&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0038-1676810"
                      "Revista" => array:7 [
                        "tituloSerie" => "Homeopathy"
                        "fecha" => "2019"
                        "volumen" => "108"
                        "numero" => "2"
                        "paginaInicial" => "139"
                        "paginaFinal" => "148"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30759480"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0004"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Telomere and telomerase&#58; biological markers of organic vital force state and homeopathic treatment effectiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0041-1726008"
                      "Revista" => array:7 [
                        "tituloSerie" => "Homeopathy"
                        "fecha" => "2021"
                        "volumen" => "110"
                        "numero" => "4"
                        "paginaInicial" => "283"
                        "paginaFinal" => "291"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34000743"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Genomic Homeopathy&#8221; proposal&#58; use of auto-isotherapic of DNA as a modulator of gene expression in chronic diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/1806-9282.20221156"
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Assoc Med Bras &#40;1992&#41;"
                        "fecha" => "2023"
                        "volumen" => "69"
                        "numero" => "1"
                        "paginaInicial" => "13"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36629657"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0006"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pseudoskeptical and pseudoscientific strategies used in attacks on homeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/1806-9282.20210367"
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Assoc Med Bras &#40;1992&#41;"
                        "fecha" => "2021"
                        "volumen" => "67"
                        "numero" => "6"
                        "paginaInicial" => "777"
                        "paginaFinal" => "780"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34709315"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0007"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Special Dossier&#58; &#8220;Scientific Evidence for Homeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/1806-9282.64.02.93"
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Assoc Med Bras &#40;1992&#41;"
                        "fecha" => "2018"
                        "volumen" => "64"
                        "numero" => "2"
                        "paginaInicial" => "93"
                        "paginaFinal" => "94"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29641670"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0008"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proofs that homeopathic medicine works&#58; Dossier &#8220;Scientific Evidence for Homeopathy&#8221; &#40;Revista de Homeopatia&#44; S&#227;o Paulo Homeopathic Medical Association&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0037-1613677"
                      "Revista" => array:6 [
                        "tituloSerie" => "Homeopathy"
                        "fecha" => "2018"
                        "volumen" => "107"
                        "numero" => "1"
                        "paginaInicial" => "45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29528478"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0009"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Scientific Evidence for Homeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Clinics &#40;Sao Paulo&#41;"
                        "fecha" => "2023"
                        "volumen" => "78"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Homeopathy is not placebo effect&#8221;&#58; proof of the scientific evidence for homeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Assoc Med Bras &#40;1992&#41;"
                        "fecha" => "2024"
                        "volumen" => "70"
                        "numero" => "4"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0011"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Homeopatia n&#227;o &#233; efeito placebo&#8221;&#58; comprova&#231;&#227;o das evid&#234;ncias cient&#237;ficas da homeopatia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2023"
                        "paginaInicial" => "223"
                        "editorial" => "Marcus Zulian Teixeira"
                        "editorialLocalizacion" => "S&#227;o Paulo &#40;SP&#41;"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;docs&#46;bvsalud&#46;org&#47;biblioref&#47;2024&#47;02&#47;1451677&#47;homeopatia-nao-e-efeito-placebo-comprovacao-das-evidencias-cie&#95;wyppAe2&#46;pdf"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0012"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Homeopathy is not placebo effect&#8221;&#58; proof of scientific evidence for homeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2024"
                        "paginaInicial" => "228"
                        "editorial" => "Marcus Zulian Teixeira"
                        "editorialLocalizacion" => "S&#227;o Paulo &#40;SP&#41;"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;docs&#46;bvsalud&#46;org&#47;biblioref&#47;2024&#47;04&#47;1551294&#47;homeopathy-is-not-placebo-effect-proof-of-scientific-evidence-&#95;IDHRIZT&#46;pdf"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0039"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La homeopat&#237;a no es efecto placebo&#58; comprobaci&#243;n de las evidencias cient&#237;ficas en homeopat&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2024"
                        "paginaInicial" => "246"
                        "editorial" => "Marcus Zulian Teixeira"
                        "editorialLocalizacion" => "S&#227;o Paulo &#40;SP&#41;"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;docs&#46;bvsalud&#46;org&#47;biblioref&#47;2024&#47;05&#47;1553352&#47;la-homeopatia-no-es-efecto-placebo-comprobacion-de-las-evidenc&#95;rkdk8el&#46;pdf"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0013"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Homeopatia n&#227;o &#233; efeito placebo&#8221;&#58; comprova&#231;&#227;o das evid&#234;ncias cient&#237;ficas da homeopatia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.11606/9786500794380"
                      "Libro" => array:4 [
                        "fecha" => "2023"
                        "paginaInicial" => "223"
                        "editorial" => "Universidade de S&#227;o Paulo"
                        "editorialLocalizacion" => "Faculdade de Medicina"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0014"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Homeopathy is not placebo effect&#8221;&#58; proof of scientific evidence for homeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.11606/9786500987591"
                      "Libro" => array:4 [
                        "fecha" => "2024"
                        "paginaInicial" => "228"
                        "editorial" => "Universidade de S&#227;o Paulo"
                        "editorialLocalizacion" => "Faculdade de Medicina"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Homeopatia n&#227;o &#233; efeito placebo&#8221;&#58; comprova&#231;&#227;o das evid&#234;ncias cient&#237;ficas da homeopatia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2023"
                        "paginaInicial" => "379"
                        "editorial" => "Marcus Zulian Teixeira"
                        "editorialLocalizacion" => "S&#227;o Paulo &#40;SP&#41;"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;amazon&#46;com&#46;br&#47;dp&#47;B0CK6JDWTJ"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0016"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Homeopathy is not placebo effect&#8221;&#58; proof of scientific evidence for homeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2024"
                        "paginaInicial" => "368"
                        "editorial" => "Marcus Zulian Teixeira"
                        "editorialLocalizacion" => "S&#227;o Paulo &#40;SP&#41;"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;amazon&#46;com&#47;dp&#47;B0CZY9BZLC"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La homeopat&#237;a no es efecto placebo&#58; comprobaci&#243;n de las evidencias cient&#237;ficas en homeopat&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2024"
                        "paginaInicial" => "386"
                        "editorial" => "Marcus Zulian Teixeira"
                        "editorialLocalizacion" => "S&#227;o Paulo &#40;SP&#41;"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;amazon&#46;com&#46;br&#47;gp&#47;product&#47;B0D3B84VPL"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0017"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiologia cl&#237;nica homeop&#225;tica&#58; premissas e princ&#237;pios para a elabora&#231;&#227;o da pesquisa cl&#237;nica em homeopatia &#91;Homeopathic clinical epidemiology&#58; premises and principles for elaboration of clinical research in homeopathy&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev&#46; Homeopatia &#40;S&#227;o Paulo&#41;"
                        "fecha" => "2022"
                        "volumen" => "84"
                        "numero" => "3-4"
                        "paginaInicial" => "4"
                        "paginaFinal" => "24"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;pesquisa&#46;bvsalud&#46;org&#47;portal&#47;resource&#47;pt&#47;biblio-1402361"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0018"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rebound effect of modern drugs&#58; serious adverse event unknown by health professionals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ramb.2013.05.003"
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Assoc Med Bras &#40;1992&#41;"
                        "fecha" => "2013"
                        "volumen" => "59"
                        "numero" => "6"
                        "paginaInicial" => "629"
                        "paginaFinal" => "638"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24211013"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0019"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Similitude in Modern Pharmacology&#8221;&#58; two decades of studies contributing to the scientific basis of the homeopathic healing principle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/1806-9282.20211362"
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Assoc Med Bras &#40;1992&#41;"
                        "fecha" => "2022"
                        "volumen" => "68"
                        "numero" => "3"
                        "paginaInicial" => "303"
                        "paginaFinal" => "307"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35442354"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Similia Similibus Curentur&#8221;&#58; The scientific grounding of the homeopathic therapeutic principle through the systematic study of the rebound effect of modern drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Clinics &#40;Sao Paulo&#41;"
                        "fecha" => "2022"
                        "volumen" => "77"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0021"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New homeopathic medicines&#58; use of modern drugs according to the principle of similitude"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.homp.2011.01.002"
                      "Revista" => array:7 [
                        "tituloSerie" => "Homeopathy"
                        "fecha" => "2011"
                        "volumen" => "100"
                        "numero" => "4"
                        "paginaInicial" => "244"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21962199"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0022"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potentized estrogen in homeopathic treatment of endometriosis-associated pelvic pain&#58; a 24-week&#44; randomized&#44; double-blind&#44; placebo-controlled study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "MZ Teixeira"
                            1 => "S Podgaec"
                            2 => "EC Baracat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejogrb.2017.01.052"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Obstet Gynecol Reprod Biol"
                        "fecha" => "2017"
                        "volumen" => "211"
                        "paginaInicial" => "48"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28187404"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0023"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;New Homeopathic Medicines&#8221; proposal&#58; a database made available in three free-access bilingual digital books"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MZ Teixeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/1806-9282.20210482"
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Assoc Med Bras &#40;1992&#41;"
                        "fecha" => "2021"
                        "volumen" => "67"
                        "numero" => "10"
                        "paginaInicial" => "1387"
                        "paginaFinal" => "1391"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35018963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0024"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The in vitro evidence for an effect of high homeopathic potencies&#8211;a systematic review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "CM Witt"
                            1 => "M Bluth"
                            2 => "H Albrecht"
                            3 => "TE Weisshuhn"
                            4 => "S Baumgartner"
                            5 => "SN Willich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ctim.2007.01.011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Complement Ther Med"
                        "fecha" => "2007"
                        "volumen" => "15"
                        "numero" => "2"
                        "paginaInicial" => "128"
                        "paginaFinal" => "138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17544864"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systematic Review of Plant-Based Homeopathic Basic Research&#58; An Update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A &#220;cker"
                            1 => "S Baumgartner"
                            2 => "A Sokol"
                            3 => "R Huber"
                            4 => "P Doesburg"
                            5 => "T J&#228;ger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0038-1639580"
                      "Revista" => array:7 [
                        "tituloSerie" => "Homeopathy"
                        "fecha" => "2018"
                        "volumen" => "107"
                        "numero" => "2"
                        "paginaInicial" => "115"
                        "paginaFinal" => "129"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29621812"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0026"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of animal models in homeopathic research&#8211;a review of 2010-2014 PubMed indexed papers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "LV Bonamin"
                            1 => "TN Cardoso"
                            2 => "AC de Carvalho"
                            3 => "JG Amaral"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Homeopathy"
                        "fecha" => "2015"
                        "volumen" => "104"
                        "numero" => "4"
                        "paginaInicial" => "283"
                        "paginaFinal" => "291"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0027"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical trials of homoeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J Kleijnen"
                            1 => "P Knipschild"
                            2 => "G ter Riet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.302.6772.316"
                      "Revista" => array:7 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1991"
                        "volumen" => "302"
                        "numero" => "6772"
                        "paginaInicial" => "316"
                        "paginaFinal" => "323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1825800"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0028"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are the clinical effects of homeopathy placebo effects&#63; A meta-analysis of placebo-controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "K Linde"
                            1 => "N Clausius"
                            2 => "G Ramirez"
                            3 => "D Melchart"
                            4 => "F Eitel"
                            5 => "LV Hedges"
                            6 => "WB Jonas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0140-6736(97)02293-9"
                      "Revista" => array:7 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1997"
                        "volumen" => "350"
                        "numero" => "9081"
                        "paginaInicial" => "834"
                        "paginaFinal" => "843"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9310601"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0029"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of study quality on outcome in placebo-controlled trials of homeopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K Linde"
                            1 => "M Scholz"
                            2 => "G Ramirez"
                            3 => "N Clausius"
                            4 => "D Melchart"
                            5 => "WB Jonas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0895-4356(99)00048-7"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Epidemiol"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "numero" => "7"
                        "paginaInicial" => "631"
                        "paginaFinal" => "636"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10391656"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence of clinical efficacy of homeopathy&#46; A meta-analysis of clinical trials&#46; HMRAG&#46; Homeopathic Medicines Research Advisory Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M Cucherat"
                            1 => "MC Haugh"
                            2 => "M Gooch"
                            3 => "JP Boissel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s002280050716"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Clin Pharmacol"
                        "fecha" => "2000"
                        "volumen" => "56"
                        "numero" => "1"
                        "paginaInicial" => "27"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10853874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0031"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomised placebo-controlled trials of individualised homeopathic treatment&#58; systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "RT Mathie"
                            1 => "SM Lloyd"
                            2 => "LA Legg"
                            3 => "J Clausen"
                            4 => "S Moss"
                            5 => "JR Davidson"
                            6 => "I Ford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/2046-4053-3-142"
                      "Revista" => array:5 [
                        "tituloSerie" => "Syst Rev"
                        "fecha" => "2014"
                        "volumen" => "3"
                        "paginaInicial" => "142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25480654"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0032"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are the clinical effects of homoeopathy placebo effects&#63; Comparative study of placebo-controlled trials of homoeopathy and allopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A Shang"
                            1 => "K Huwiler-M&#252;ntener"
                            2 => "L Nartey"
                            3 => "P J&#252;ni"
                            4 => "S D&#246;rig"
                            5 => "JA Sterne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(05)67177-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2005"
                        "volumen" => "366"
                        "numero" => "9487"
                        "paginaInicial" => "726"
                        "paginaFinal" => "732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16125589"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0033"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "NHMRC Information Paper&#58; Evidence on the effectiveness of homeopathy for treating health conditions &#91;March 2015&#93;&#46; &#91;cited on Apr&#46; 27&#44; 2024&#93;&#46; Available from&#58; <a target="_blank" href="https://www.hri-research.org/wp-content/uploads/2015/07/NHMRC-Information-Paper-Mar2015.pdf">https&#58;&#47;&#47;www&#46;hri-research&#46;org&#47;wp-content&#47;uploads&#47;2015&#47;07&#47;NHMRC-Information-Paper-Mar2015&#46;pdf</a>&#46;"
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0034"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of homoeopathic treatment&#58; Systematic review of meta-analyses of randomised placebo-controlled homoeopathy trials for any indication"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "HJ Hamre"
                            1 => "A Glockmann"
                            2 => "K von Ammon"
                            3 => "DS Riley"
                            4 => "H Kiene"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13643-023-02313-2"
                      "Revista" => array:5 [
                        "tituloSerie" => "Syst Rev"
                        "fecha" => "2023"
                        "volumen" => "12"
                        "paginaInicial" => "191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/37805577"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Benchmarking the burden of 100 diseases&#58; results of a nationwide representative survey within general practices"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "EPI3-LA-SER Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L Grimaldi-Bensouda"
                            1 => "B Begaud"
                            2 => "F Lert"
                            3 => "F Rouillon"
                            4 => "J Massol"
                            5 => "D Guillemot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "BMJ Open"
                        "fecha" => "2011"
                        "volumen" => "1"
                        "numero" => "2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0036"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Integration of homeopathy and complementary medicine in the Tuscan Public Health System and the experience of the homeopathic clinic of the Lucca Hospital"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E Rossi"
                            1 => "M Di Stefano"
                            2 => "M Picchi"
                            3 => "MA Panozzo"
                            4 => "C Noberasco"
                            5 => "L Nurra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Homeopathy"
                        "fecha" => "2018"
                        "volumen" => "107"
                        "numero" => "2"
                        "paginaInicial" => "90"
                        "paginaFinal" => "98"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0037"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How healthy are chronically ill patients after eight years of homeopathic treatment&#63;&#8211;Results from a long term observational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "CM Witt"
                            1 => "R L&#252;dtke"
                            2 => "N Mengler"
                            3 => "SN Willich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2458-8-413"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Public Health"
                        "fecha" => "2008"
                        "volumen" => "8"
                        "paginaInicial" => "413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19091085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0038"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effectiveness and cost-effectiveness of treatment with additional enrollment to a homeopathic integrated care contract in Germany"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B Kass"
                            1 => "K Icke"
                            2 => "CM Witt"
                            3 => "T Reinhold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12913-020-05706-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Health Serv Res"
                        "fecha" => "2020"
                        "volumen" => "20"
                        "numero" => "1"
                        "paginaInicial" => "872"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32933511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/000000790000000C/v123_202411010523/S1807593224001339/v123_202411010523/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "94922"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Editorials"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/18075932/000000790000000C/v123_202411010523/S1807593224001339/v123_202411010523/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593224001339?idApp=UINPBA00004N"
]
Article information
ISSN: 18075932
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 28 8 36
2024 October 279 77 356
2024 September 168 65 233
2024 August 171 101 272

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos