Demographic characteristics and clinical-radiological correlation in patients with indications for Total Knee Arthroplasty: A cross-sectional study

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Clinical and radiographic results with a mean nine-year follow-up" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "en" ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0002" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1334 "Ancho" => 2500 "Tamanyo" => 200283 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0002" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "(A) Posterior dislocation. (B) Medial opening with avulsion of medial collateral ligament. (C) 6.1 years postoperative single leg standing AP X-Ray showing no medial opening. (D) Lateral view showing good position with patella baja." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Fontes Cintra, Mauricio Etchebehere, Eduardo Rached, Giancarlo Cavenaghi, Paulo Eduardo Dias Rahal, Rodrigo Gonçalves Pagnano" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Francisco Fontes" "apellidos" => "Cintra" ] 1 => array:2 [ "nombre" => "Mauricio" "apellidos" => "Etchebehere" ] 2 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Rached" ] 3 => array:2 [ "nombre" => "Giancarlo" "apellidos" => "Cavenaghi" ] 4 => array:2 [ "nombre" => "Paulo Eduardo Dias" "apellidos" => "Rahal" ] 5 => array:2 [ "nombre" => "Rodrigo Gonçalves" "apellidos" => "Pagnano" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001">•MBV revision knee modular system (MBVS) could be a solution for complex scenarios.</li><li class="elsevierStyleListItem" id="celistitem0002">•In a mean follow up of 9.1 years, the MBVS showed 93.5 % of overall survivorship.</li><li class="elsevierStyleListItem" id="celistitem0003">•The MBV should not be used in cases with major instability.</li></ul>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593224001856?idApp=UINPBA00004N" "url" => "/18075932/000000790000000C/v115_202410170932/S1807593224001856/v115_202410170932/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S1807593224001753" "issn" => "18075932" "doi" => "10.1016/j.clinsp.2024.100498" "estado" => "S250" "fechaPublicacion" => "2024-01-01" "aid" => "100498" "copyright" => "HCFMUSP" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original articles" "titulo" => "Intraoperative changes of surgical approach and a second surgery after percutaneous endoscopic surgery for lumbar spinal stenosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "en" ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1945 "Ancho" => 2667 "Tamanyo" => 470835 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Case 2, a male patient aged 63 years, with lumbar spinal stenosis in the L3–5 space. (A‒B) Preoperative anteroposterior and lateral X-Ray revealed severe lumbar vertebral osteoporosis. (C‒D) Preoperative MRI revealed LIDH and severe lumbar spinal stenosis in the L3–5 space. PIED was performed first. The anatomic structure was not clearly visualized, with loss of orientation. This patient was intraoperatively shifted to MMED with adequate decompression, loosening of the dural sac and nerve root." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "LianSong Lu, ZhenShan Yuan, HaoJie Li, ShaoHua Sun" "autores" => array:4 [ 0 => array:2 [ "nombre" => "LianSong" "apellidos" => "Lu" ] 1 => array:2 [ "nombre" => "ZhenShan" "apellidos" => "Yuan" ] 2 => array:2 [ "nombre" => "HaoJie" "apellidos" => "Li" ] 3 => array:2 [ "nombre" => "ShaoHua" "apellidos" => "Sun" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001">•Surgical approach changes due to severe hyperplasia, obscure anatomic structure, etc.</li><li class="elsevierStyleListItem" id="celistitem0002">•A second surgery is due to nerve entrapment, nerve injury, lumbar instability, etc.</li><li class="elsevierStyleListItem" id="celistitem0003">•Appropriate indications and surgical approaches are chosen accordingly.</li></ul>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593224001753?idApp=UINPBA00004N" "url" => "/18075932/000000790000000C/v115_202410170932/S1807593224001753/v115_202410170932/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "Original articles" "titulo" => "Demographic characteristics and clinical-radiological correlation in patients with indications for Total Knee Arthroplasty: A cross-sectional study" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Diego Ubrig Munhoz, Andre Giardino Moreira da Silva, Pedro Nogueira Giglio, Camilo Partezani Helito, Riccardo Gomes Gobbi, Luís Eduardo Passarelli Tirico" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Diego Ubrig" "apellidos" => "Munhoz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] ] ] 1 => array:4 [ "nombre" => "Andre Giardino" "apellidos" => "Moreira da Silva" "email" => array:1 [ 0 => "andre.giardino1@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0001" ] ] ] 2 => array:3 [ "nombre" => "Pedro Nogueira" "apellidos" => "Giglio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] ] ] 3 => array:3 [ "nombre" => "Camilo Partezani" "apellidos" => "Helito" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0002" ] ] ] 4 => array:3 [ "nombre" => "Riccardo Gomes" "apellidos" => "Gobbi" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "c" "identificador" => "aff0003" ] ] ] 5 => array:3 [ "nombre" => "Luís Eduardo Passarelli" "apellidos" => "Tirico" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0001" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Grupo de Joelho, Instituto de Ortopedia e Traumatologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil" "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Hospital Sírio Libanês, São Paulo, SP, Brazil" "etiqueta" => "b" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "HCor Hospital do Coração, São Paulo, SP, Brazil" "etiqueta" => "c" "identificador" => "aff0003" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0001" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0003" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1439 "Ancho" => 2500 "Tamanyo" => 46713 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0006" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "KOOS total score according to the Kellgren-Lawrence classification in patients with knee osteoarthritis." ] ] ] "textoCompleto" => "IntroductionOsteoarthritis is the most common joint disease,<a class="elsevierStyleCrossRef" href="#bib0001">1</a> and the knee is the most affected site,<a class="elsevierStyleCrossRef" href="#bib0002">2</a> occurring in around 10% of the population over 60 years of age.<a class="elsevierStyleCrossRef" href="#bib0003">3</a> The signs and symptoms include knee pain, stiffness and loss of range of motion, crepitus, loss of function, and need for orthopedic devices.<a class="elsevierStyleCrossRef" href="#bib0004">4</a> Although the main complaint of patients is pain,<a class="elsevierStyleCrossRef" href="#bib0005">5</a> it is not a reliable indicator of the severity of gonarthrosis when assessed in isolation, as patients adjust their activity levels to manage this symptom.<a class="elsevierStyleCrossRef" href="#bib0006">6</a> Regarding the clinical assessment of patients with gonarthrosis, there are validated functional scores, such as KOOS (Knee injury and Osteoarthritis Outcome Score)<a class="elsevierStyleCrossRef" href="#bib0007">7</a> and KSS (Knee Society Score System).<a class="elsevierStyleCrossRef" href="#bib0008">8</a> Concerning radiographic assessment, Kellgren-Lawrence classification,<a class="elsevierStyleCrossRef" href="#bib0009">9</a> the most widely used system, evaluates the presence of the classic signs of osteoarthrosis (narrowing of the joint space, presence of osteophytes, subchondral sclerosis, presence of deformity of the joint surface).Previous studies have demonstrated a clinical-radiographic dissociation in patients with knee osteoarthritis. A population study that evaluated the radiographic prevalence of knee osteoarthritis (considering radiographic osteoarthritis patients with Kellgren-Lawrence ≥ 1), found up to 60% of asymptomatic patients among those with radiographic osteoarthritis.<a class="elsevierStyleCrossRef" href="#bib0010">10</a> On the other hand, in the initial stages of osteoarthrosis, there is a symptomatic phase that precedes the radiographic changes.<a class="elsevierStyleCrossRefs" href="#bib0011">11–13</a> At this stage, magnetic ressonance imaging (MRI) may reveal lesions in the articular cartilage, subchondral bone, bone marrow, and/or menisci, which are likely associated with symptoms.<a class="elsevierStyleCrossRef" href="#bib0012">12</a>,<a class="elsevierStyleCrossRef" href="#bib0013">13</a> Case et al., in their case-control study, showed that patients who developed radiographic osteoarthritis presented progressive symptoms of knee pain, stiffness and difficulties with functional tasks in the pre-radiographic phase.<a class="elsevierStyleCrossRef" href="#bib0013">13</a> Therefore, there are patients with radiographic osteoarthritis with no symptoms, and vice versa.In subjects with indications for Total Knee Arthroplasty (TKA), the gold standard surgical treatment for knee osteoarthritis, the Kellgren-Lawrence classification may underestimate the severity of gonarthrosis. In their study, Abdelaziz et al. demonstrated a discrepancy of 66.1% between the preoperative Kellgren-Lawrence classification and the intraoperative findings of joint degeneration in patients undergoing TKA.<a class="elsevierStyleCrossRef" href="#bib0014">14</a> Therefore, a full clinical assessment and a better understanding of the correlation between symptoms and radiographic changes are essential to determine the right moment to recommend surgery.Although it is well established in the literature that there is a weak correlation between clinical symptoms and radiographic changes in patients with knee osteoarthritis,<a class="elsevierStyleCrossRef" href="#bib0006">6</a>,<a class="elsevierStyleCrossRefs" href="#bib0015">15–17</a> the strength of this correlation can be variable in different phases of the disease. To date, there are still no studies that have evaluated the correlation between Kellgren-Lawrence classification and clinical-functional scores in TKA candidates, whose clinical and radiological parameters and their correlation are fundamental in therapeutic decision-making. In this context, this study aims to evaluate the correlation between KOOS and KSS clinical scores and the radiographic findings classified according to Kellgren-Lawrence in TKA candidates in a tertiary hospital. The secondary objective is to carry out an epidemiological analysis of the studied population, evaluating the variables of age, gender, Body Mass Index (BMI), comorbidities, and laterality of the joint disease.MethodsA cross-sectional study was performed in a tertiary public hospital following STROBE guidelines. The study was approved by the University of São Paulo Institutional Review Board with internal number CAAE 08496919.5.0000.0068, and an Informed Consent Form was signed by all participants.A total of 328 patients with knee osteoarthritis and indications for TKA were selected. 118 had outdated registration data or contact was not possible, 52 did not agree to participate in the study, 20 did not turn up to the appointment, 10 had already undergone surgery and 8 had died. In total, 120 patients (189 knees) were included in the present study.The inclusion criteria were patients with knee osteoarthritis (unilateral or bilateral) who had any indication for TKA between January 2007 and April 2018. Non-inclusion criteria included patients who did not respond to contact attempts, patients who had already undergone TKA and patients who refused to participate.Demographic data collection was conducted using questionnaires, which included age, gender, weight, height, Body Mass Index (BMI), clinical comorbidities, and laterality of gonarthrosis. The analysis of functionality, quality of life, and physical parameters was carried out using two clinical-functional scores: KOOS (Knee Injury and Osteoarthritis Outcome Score) ‒ a clinical scale with 5 subsections ranging from 0 (worst situation) to 100 (best situation);<a class="elsevierStyleCrossRef" href="#bib0007">7</a> and KSS (Knee Society Score System) ‒ a clinical scale, ranging from 0 (worst situation) to 100 (best situation).<a class="elsevierStyleCrossRef" href="#bib0008">8</a>Radiographic analysis was carried out based on full-limb and knee radiographs, including an anteroposterior weight-bearing view, a lateral view with 30° of flexion, and a skyline view. The radiographs were classified by an orthopedic knee surgeon using the Kellgren-Lawrence system (<a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a>), which is an ordinal scale graded from 0 (absence of radiographic features of osteoarthritis) to 4 (large osteophytes, pronounced joint space narrowing, severe sclerosis and defined bone deformity).<a class="elsevierStyleCrossRef" href="#bib0009">9</a><elsevierMultimedia ident="fig0001"></elsevierMultimedia>Statistical analysisQualitative variables were presented as absolute frequencies and percentages. For quantitative variables, the mean, median, standard deviation, minimum value, and maximum value were calculated. Correlation coefficients between clinical scores and radiographic classification were obtained using Kendall's tau test (τ-Kendall), whose values may vary between -1 and +1. A positive value means that variables have a direct relationship, a negative value means that the variables are inversely related, and zero means there is no correlation between the two variables. The strength of the correlation increases both from 0 to +1, and from 0 to -1. The values of +1 or -1 mean a perfect correlation.<a class="elsevierStyleCrossRef" href="#bib0018">18</a>The analysis was performed using the statistical software SPSS v.25 for Windows.ResultsIn total, 120 patients (189 knees) were included in the analysis. The mean age was 64 years (34 to 98 years), with the majority being female (65%). The mean BMI was 30.3 kg/cm2. Systemic arterial hypertension was the most common comorbidity (49.1%), followed by diabetes mellitus (16.6%). 57.5% of patients had bilateral gonarthrosis. Epidemiological characteristics and most common comorbidities were described in <a class="elsevierStyleCrossRef" href="#tbl0001">Table 1</a>.<elsevierMultimedia ident="tbl0001"></elsevierMultimedia>The mean and standard deviation values of the clinical scores according to their distributions in the Kellgren-Lawrence classification are presented in <a class="elsevierStyleCrossRef" href="#tbl0002">Table 2</a>.<elsevierMultimedia ident="tbl0002"></elsevierMultimedia>A weak negative correlation was observed between all clinical scores and radiographic classification, and the results were statistically significant under the null hypothesis. The clinical score with the strongest negative correlation was the KSS (τ = -0.356; p < 0.001) and the weakest negative correlation was the KOOS-sport and recreation function (τ = -0.142; p = 0.025). Test results demonstrating correlations between clinical scores and radiographic classification are presented in <a class="elsevierStyleCrossRef" href="#tbl0003">Table 3</a>.<elsevierMultimedia ident="tbl0003"></elsevierMultimedia>The distribution of patients between KSS and total KOOS scores according to the radiographic classification are summarized in the following box plots (<a class="elsevierStyleCrossRef" href="#fig0002">Figs. 2</a> and <a class="elsevierStyleCrossRef" href="#fig0003">3</a>)<elsevierMultimedia ident="fig0002"></elsevierMultimedia><elsevierMultimedia ident="fig0003"></elsevierMultimedia>DiscussionThis study intended to evaluate TKA candidates and correlate their clinical scores with their radiographic classifications, a fact that had not been previously reported in the literature, in addition to carrying out an epidemiological analysis of the population.In the sample analyzed, the authors found epidemiological data that are similar to those previously described, with a mean age of 64.1 years and a female predominance (65%). In the literature, knee osteoarthritis is found with a frequency of up to 13% in the population aged 60 years or over and is more prevalent in women than in men in the elderly population.<a class="elsevierStyleCrossRef" href="#bib0019">19</a> In the present study, obesity proved to be very prevalent, being present in 50% of cases. There is also a high prevalence of systemic arterial hypertension (52.7%) and diabetes mellitus (17.9%). These findings are in accordance with previous literature, in which higher grades in the Ahlbäck radiographic classification<a class="elsevierStyleCrossRef" href="#bib0020">20</a> were associated with the occurrence of systemic arterial hypertension, and had a weak correlation with the patient's height and weight, but moderate correlation with BMI.<a class="elsevierStyleCrossRef" href="#bib0021">21</a> Furthermore, patients with knee osteoarthritis at Kellgren-Lawrence Grade 2 or above have a higher prevalence of metabolic syndrome, diabetes, and hypertension.<a class="elsevierStyleCrossRef" href="#bib0022">22</a>When comparing the mean functional scores reported in this study with those described in the literature, the scores in this cohort were significantly lower, even in the moderate radiographic grades. In a population study that evaluated 981 patients with knee osteoarthritis, a mean total KOOS of 55.33 was found with a standard deviation of ± 20.641.<a class="elsevierStyleCrossRef" href="#bib0023">23</a> In this study, patients with Kellgren-Lawrence Grade 2 had a mean total KOOS of 31.87, Grade 3 of 22.65, and Grade 4 of 21.45. These lower clinical score values reported are probably due to the fact that only patients with surgical indications were included in this study, which infers that they have more significant symptoms.Regarding the clinical-radiographic correlation, a weak and inversely proportional correlation was observed between all clinical scores analyzed, including the subitems, and the Kellgren-Lawrence classification. As described in <a class="elsevierStyleCrossRef" href="#tbl0003">Table 3</a>, all correlation values between the scores and the radiographic classification were negative, denoting an inversely proportional correlation between these variables, and result values are closer to zero than to -1, denoting a weak correlation. Among clinical scores evaluated, KSS showed the highest correlation with the Kellgren-Lawrence classification (τ = -0.356; p < 0.001), followed by KOOS-quality of life (τ = -0.176; p = 0.004), KOOS-total score (τ=-0.166; p = 0.004), KOOS-function in daily living (τ = -0.160; p = 0.005) and KOOS-symptoms (τ = -0.159; p = 0.006). KOOS-pain (τ = -0.149; p = 0.01) and KOOS-sport and recreation function (τ = -0.142; p = 0.025) scores had the weakest correlations.Therefore, although radiographic classification is an important parameter in the assessment of patients with knee osteoarthritis, its correlation with the clinical presentation proved to be weak and not very consistent. These findings corroborate previous literature, which shows that the prevalence of pain is greater as radiographic osteoarthritis worsens,<a class="elsevierStyleCrossRef" href="#bib0024">24</a> and that these variables present themselves as cause and consequence,<a class="elsevierStyleCrossRef" href="#bib0025">25</a> but neither the intensity of pain nor the worsening of other symptoms were consistently associated with radiographic changes.<a class="elsevierStyleCrossRef" href="#bib0026">26</a>,<a class="elsevierStyleCrossRef" href="#bib0027">27</a> Other biological, psychological, and social factors probably influence the diverse symptoms of osteoarthrosis and the radiographic worsening is not necessarily decisive in the functional worsening of patients.Among the limitations of the study are the low reproducibility between observers and the lack of intra-observer uniformity of the Kellgren-Lawrence classification.<a class="elsevierStyleCrossRef" href="#bib0028">28</a> Another point is the fact that the Kellgren-Lawrence classification limits the final stage of the disease to Stage 4. However, in the analysis with MRI, a progression of the disease is still seen in patients classified as Stage 4, with worsening of cartilage damage, especially in the less affected tibiofemoral compartment, with fluctuations in bone marrow edema and synovitis. Despite this, Kellgren-Lawrence grades in plain radiographs were highly correlated with the MRI grades.<a class="elsevierStyleCrossRef" href="#bib0029">29</a> However, it is noteworthy that the diagnosis of knee osteoarthrosis is more sensitive with the use of MRI than with the Kellgren-Lawrence scale.<a class="elsevierStyleCrossRef" href="#bib0030">30</a> As described for the Ahlbäck classification, the Kellgren-Lawrence classification should not be used routinely without the aid of adequate clinical assessment.<a class="elsevierStyleCrossRef" href="#bib0031">31</a>ConclusionThe present study concludes that there is a weak correlation between the severity of radiographic changes and clinical symptoms in candidates for TKA. Among clinical scores, the objective KSS had the highest correlation with radiographic severity.Authors’ contributionsDiego Ubrig Munhoz: Conceptualization; methodology; investigation; data curation; writing-original draft.Andre Giardino Moreira da Silva: Conceptualization; methodology; investigation; data curation; writing-original draft.Pedro Nogueira Giglio: Methodology; data curation; formal analysis.Camilo Partezani Helito: Methodology; supervision; project administration.Riccardo Gomes Gobbi: Conceptualization; supervision; project administration.Luís Eduardo Passarelli Tirico: Conceptualization; writing-review & editing; supervision; project administration. All authors read and approved the final manuscript.Ethics approvalThis study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the University of São Paulo (CAAE 08496919.5.0000.0068; 15/04/2019)." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres2273791" "titulo" => "Highlights" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abss0001" ] ] ] 1 => array:3 [ "identificador" => "xres2273790" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0002" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abss0003" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abss0004" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0005" "titulo" => "Conclusion" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1895003" "titulo" => "Keywords" ] 3 => array:2 [ "identificador" => "sec0001" "titulo" => "Introduction" ] 4 => array:3 [ "identificador" => "sec0002" "titulo" => "Methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0003" "titulo" => "Statistical analysis" ] ] ] 5 => array:2 [ "identificador" => "sec0004" "titulo" => "Results" ] 6 => array:2 [ "identificador" => "sec0005" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0006" "titulo" => "Conclusion" ] 8 => array:2 [ "identificador" => "sec0007" "titulo" => "Authors’ contributions" ] 9 => array:2 [ "identificador" => "sec0008" "titulo" => "Ethics approval" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-03-08" "fechaAceptado" => "2024-08-25" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1895003" "palabras" => array:6 [ 0 => "Total Knee Arthroplasty" 1 => "Gonarthrosis" 2 => "KSS" 3 => "KOOS" 4 => "Kellgren-Lawrence" 5 => "Osteoarthritis" ] ] ] ] "tieneResumen" => true "highlights" => array:2 [ "titulo" => "Highlights" "resumen" => "<ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001">•Knee osteoarthritis is a common joint disease.</li><li class="elsevierStyleListItem" id="celistitem0002">•Total Knee Arthroplasty (TKA) is the gold standard surgical treatment after failed conservative management.</li><li class="elsevierStyleListItem" id="celistitem0003">•There is a weak correlation between radiographic worsening and functional impairment in patients with knee osteoarthritis and indication for TKA.</li></ul>" ] "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "ObjectiveThe objective of this study is to correlate clinical symptoms and functionality, using the KOOS (Knee Injury and Osteoarthritis Outcome Score) and KSS (Knee Society Score System) scores, with the radiographic changes, using the Kellgren-Lawrence classification, in patients with knee osteoarthritis and indications for Total Knee Arthroplasty (TKA). Methods120 patients (189 knees) with gonarthrosis and indications for TKA were included in the study. Demographic questionnaires were applied, and clinical and functional assessment was carried out using the KOOS and KSS scores. Knee radiographs were taken and graded according to Kellgren-Lawrence. The clinical scores were compared with the radiographic classification to establish a correlation between these two measurements. Statistical analysis was performed using the τ-Kendall correlation test. ResultsWeak and inversely proportional correlations were found between the clinical scores and the radiographic classification. Among clinical scores evaluated, KSS showed the highest correlation with Kellgren-Lawrence classification (τ = -0.356; p < 0.001), followed by KOOS-quality of life (τ = -0.176; p = 0.004), KOOS-total score (τ = -0.166; p = 0.004), KOOS-function in daily living (τ = -0.160; p = 0.005) and KOOS-symptoms (τ = -0.159; p = 0.006). KOOS-pain (τ = -0.149; p = 0.01) and KOOS-sport and recreation function (τ = -0.142; p = 0.025) scores had the weakest correlations. ConclusionThere is a weak correlation between the clinical-functional scores of TKA candidates and their radiographic classification by Kellgren-Lawrence. Among clinical scores evaluated, KSS had the strongest negative correlation with the radiographic classification." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0002" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abss0003" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abss0004" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0005" "titulo" => "Conclusion" ] ] ] ] "multimedia" => array:6 [ 0 => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 851 "Ancho" => 2917 "Tamanyo" => 189146 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0004" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Knee radiographs classified by Kellgren-Lawrence system. (A) Kellgren-Lawrence 1 (doubtful joint space narrowing and possible osteophytic lipping); (B) Kellgren-Lawrence 2 (definite osteophytes and possible joint space narrowing); (C) Kellgren-Lawrence 3 (moderate multiple osteophytes, definite narrowing of joint space, some sclerosis and possible deformity of bone ends); (D) Kellgren-Lawrence 4 (large osteophytes, marked narrowing of joint space, severe sclerosis, and definite deformity of bone ends)." ] ] 1 => array:8 [ "identificador" => "fig0002" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1455 "Ancho" => 2500 "Tamanyo" => 83546 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0005" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "KSS objective score according to the Kellgren-Lawrence classification in patients with knee osteoarthritis." ] ] 2 => array:8 [ "identificador" => "fig0003" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1439 "Ancho" => 2500 "Tamanyo" => 46713 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0006" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "KOOS total score according to the Kellgren-Lawrence classification in patients with knee osteoarthritis." ] ] 3 => array:8 [ "identificador" => "tbl0001" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "SD, Standard Deviation; min, minimum value; max, maximum value." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0001"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col">Characteristic \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0002"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col">n (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0003"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0004"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col">Median (min‒max) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><a name="en0005"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0006"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">n = 120 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0007"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0008"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0009"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0010"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0011"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">64.1 (9.5) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0012"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">64 (34‒98) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0013"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Gender \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0014"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0015"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0016"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0017"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0018"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">78 (65) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0019"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0020"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0021"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0022"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">42 (35) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0023"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0024"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0025"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Weight (kg) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0026"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0027"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">77.9 (15.6) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0028"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">78 (48‒140) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0029"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Height (cm) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0030"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0031"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">160.7 (9.2) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0032"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">160 (142‒180) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0033"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">BMI (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0034"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0035"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">30.3 (5.2) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0036"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">30.1 (20.7‒49.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0037"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Smoking \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0038"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">9 (7.5) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0039"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0040"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0041"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Diabetes mellitus \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0042"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">20 (16.6) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0043"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0044"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0045"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Arterial hypertension \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0046"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">59 (49.1) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0047"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0048"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0049"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Dyslipidemia \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0050"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">11 (9.1) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0051"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0052"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0053"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Thyroid disorder \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0054"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">12 (10) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0055"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0056"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0057"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Depression \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0058"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">5 (4.1) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0059"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0060"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0061"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Coronary disease \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0062"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">5 (4.1) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0063"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0064"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0065"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Heart Failure \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0066"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">10 (8.3) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0067"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0068"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0069"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Rheumatoid arthritis \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0070"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">15 (12.5) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0071"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0072"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0073"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Knee osteoarthritis \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0074"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0075"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0076"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0077"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Right \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0078"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">27 (22.5) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0079"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0080"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0081"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Left \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0082"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">24 (20) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0083"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0084"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0085"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">Bilateral \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0086"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">69 (57.5) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0087"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0088"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3692585.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Epidemiological characteristics of patients with knee osteoarthritis." ] ] 4 => array:8 [ "identificador" => "tbl0002" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0002" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "SD, Standard Deviation." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0089"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowgroup " rowspan="2" align="left" valign="top" scope="col">Clinical score</th><a name="en0090"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Kellgren-Lawrence classification</th></tr><tr title="table-row"><a name="en0092"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col">Grade 2 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0093"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col">Grade 3 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0094"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col">Grade 4 \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><a name="en00d96"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0096"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">n = 45 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0097"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">n = 62 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0098"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">n=82 \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0099"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top">KSS</td></tr><tr title="table-row"><a name="en0100"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0101"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">42.7 (19.3) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0102"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">30.7 (20.4) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0103"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">18.9 (18.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0104"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top">KOOS total</td></tr><tr title="table-row"><a name="en0105"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0106"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">31.9 (18.2) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0107"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">22.7 (16.3) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0108"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">21.5 (16.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0109"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top">KOOS-pain</td></tr><tr title="table-row"><a name="en0110"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0111"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">35.3 (20.9) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0112"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">24.7 (18) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0113"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">24.8 (20) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0114"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top">KOOS-symptoms</td></tr><tr title="table-row"><a name="en0115"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0116"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">40 (20.5) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0117"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">33 (19.7) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0118"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">29.6 (21.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0119"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top">KOOS-function in daily living</td></tr><tr title="table-row"><a name="en0120"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0121"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">34.3 (21.2) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0122"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">23.2 (20) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0123"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">22.7 (20.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0124"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top">KOOS-sport and recreation function</td></tr><tr title="table-row"><a name="en0125"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0126"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">12.4 (15.6) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0127"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">7.2 (12.7) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0128"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">5.6 (9.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0129"></a><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top">KOOS-quality of life</td></tr><tr title="table-row"><a name="en0130"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0131"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">23.9 (20.1) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0132"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">15 (18.8) \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0133"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">13.9 (16.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3692586.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Mean and standard deviation of clinical scores according to Kellgren-Lawrence classification in TKA candidates." ] ] 5 => array:8 [ "identificador" => "tbl0003" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0003" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0134"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowgroup " align="left" valign="top" scope="col">Clinical score \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0135"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Kellgren-Lawrence classification \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0136"></a><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowgroup " align="left" valign="top" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><a name="en0138a"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0138"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black">τ-Kendall \t\t\t\t\t\t\n \t\t\t\t\t\t</th><a name="en0138aa"></a><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0140"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">KSS score objetivo \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0141"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">-0.356 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0142"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0143"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">KOOS score \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0144"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">-0.166 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0145"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.004 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0146"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">KOOS-pain \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0147"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">-0.149 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0148"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.010 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0149"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">KOOS-symptoms \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0150"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">-0.159 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0151"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0152"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">KOOS-function in daily living \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0153"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">-0.160 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0154"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0155"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">KOOS-sport and recreation function \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0156"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">-0.142 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0157"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.025 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><a name="en0158"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">KOOS-quality of life \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0159"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">-0.176 \t\t\t\t\t\t\n \t\t\t\t</td><a name="en0160"></a><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="top">0.004 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3692584.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Correlation between the KSS and KOOS clinical scores and the Kellgren-Lawrence classification in 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Diego Ubrig Munhoza, Andre Giardino Moreira da Silvaa,

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andre.giardino1@gmail.com

Corresponding author.

, Pedro Nogueira Giglioa, Camilo Partezani Helitoa,b, Riccardo Gomes Gobbia,c, Luís Eduardo Passarelli Tiricoa

a Grupo de Joelho, Instituto de Ortopedia e Traumatologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil

b Hospital Sírio Libanês, São Paulo, SP, Brazil

c HCor Hospital do Coração, São Paulo, SP, Brazil

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as patients adjust their activity levels to manage this symptom&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a> Regarding the clinical assessment of patients with gonarthrosis&#44; there are validated functional scores&#44; such as KOOS &#40;Knee injury and Osteoarthritis Outcome Score&#41;<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> and KSS &#40;Knee Society Score System&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0008"><span class="elsevierStyleSup">8</span></a> Concerning radiographic assessment&#44; Kellgren-Lawrence classification&#44;<a class="elsevierStyleCrossRef" href="#bib0009"><span class="elsevierStyleSup">9</span></a> the most widely used system&#44; evaluates the presence of the classic signs of osteoarthrosis &#40;narrowing of the joint space&#44; presence of osteophytes&#44; subchondral sclerosis&#44; presence of deformity of the joint surface&#41;&#46;</p><p id="para0009" class="elsevierStylePara elsevierViewall">Previous studies have demonstrated a clinical-radiographic dissociation in patients with knee osteoarthritis&#46; A population study that evaluated the radiographic prevalence of knee osteoarthritis &#40;considering radiographic osteoarthritis patients with Kellgren-Lawrence &#8805; 1&#41;&#44; found up to 60&#37; of asymptomatic patients among those with radiographic osteoarthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">10</span></a> On the other hand&#44; in the initial stages of osteoarthrosis&#44; there is a symptomatic phase that precedes the radiographic changes&#46;<a class="elsevierStyleCrossRefs" href="#bib0011"><span class="elsevierStyleSup">11&#8211;13</span></a> At this stage&#44; magnetic ressonance imaging &#40;MRI&#41; may reveal lesions in the articular cartilage&#44; subchondral bone&#44; bone marrow&#44; and&#47;or menisci&#44; which are likely associated with symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0012"><span class="elsevierStyleSup">12</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0013"><span class="elsevierStyleSup">13</span></a> Case et al&#46;&#44; in their case-control study&#44; showed that patients who developed radiographic osteoarthritis presented progressive symptoms of knee pain&#44; stiffness and difficulties with functional tasks in the pre-radiographic phase&#46;<a class="elsevierStyleCrossRef" href="#bib0013"><span class="elsevierStyleSup">13</span></a> Therefore&#44; there are patients with radiographic osteoarthritis with no symptoms&#44; and vice versa&#46;</p><p id="para0010" class="elsevierStylePara elsevierViewall">In subjects with indications for Total Knee Arthroplasty &#40;TKA&#41;&#44; the gold standard surgical treatment for knee osteoarthritis&#44; the Kellgren-Lawrence classification may underestimate the severity of gonarthrosis&#46; In their study&#44; Abdelaziz et al&#46; demonstrated a discrepancy of 66&#46;1&#37; between the preoperative Kellgren-Lawrence classification and the intraoperative findings of joint degeneration in patients undergoing TKA&#46;<a class="elsevierStyleCrossRef" href="#bib0014"><span class="elsevierStyleSup">14</span></a> Therefore&#44; a full clinical assessment and a better understanding of the correlation between symptoms and radiographic changes are essential to determine the right moment to recommend surgery&#46;</p><p id="para0011" class="elsevierStylePara elsevierViewall">Although it is well established in the literature that there is a weak correlation between clinical symptoms and radiographic changes in patients with knee osteoarthritis&#44;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">15&#8211;17</span></a> the strength of this correlation can be variable in different phases of the disease&#46; To date&#44; there are still no studies that have evaluated the correlation between Kellgren-Lawrence classification and clinical-functional scores in TKA candidates&#44; whose clinical and radiological parameters and their correlation are fundamental in therapeutic decision-making&#46; In this context&#44; this study aims to evaluate the correlation between KOOS and KSS clinical scores and the radiographic findings classified according to Kellgren-Lawrence in TKA candidates in a tertiary hospital&#46; The secondary objective is to carry out an epidemiological analysis of the studied population&#44; evaluating the variables of age&#44; gender&#44; Body Mass Index &#40;BMI&#41;&#44; comorbidities&#44; and laterality of the joint disease&#46;</p></span><span id="sec0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0009">Methods</span><p id="para0012" class="elsevierStylePara elsevierViewall">A cross-sectional study was performed in a tertiary public hospital following STROBE guidelines&#46; The study was approved by the University of S&#227;o Paulo Institutional Review Board with internal number CAAE 08496919&#46;5&#46;0000&#46;0068&#44; and an Informed Consent Form was signed by all participants&#46;</p><p id="para0013" class="elsevierStylePara elsevierViewall">A total of 328 patients with knee osteoarthritis and indications for TKA were selected&#46; 118 had outdated registration data or contact was not possible&#44; 52 did not agree to participate in the study&#44; 20 did not turn up to the appointment&#44; 10 had already undergone surgery and 8 had died&#46; In total&#44; 120 patients &#40;189 knees&#41; were included in the present study&#46;</p><p id="para0014" class="elsevierStylePara elsevierViewall">The inclusion criteria were patients with knee osteoarthritis &#40;unilateral or bilateral&#41; who had any indication for TKA between January 2007 and April 2018&#46; Non-inclusion criteria included patients who did not respond to contact attempts&#44; patients who had already undergone TKA and patients who refused to participate&#46;</p><p id="para0015" class="elsevierStylePara elsevierViewall">Demographic data collection was conducted using questionnaires&#44; which included age&#44; gender&#44; weight&#44; height&#44; Body Mass Index &#40;BMI&#41;&#44; clinical comorbidities&#44; and laterality of gonarthrosis&#46; The analysis of functionality&#44; quality of life&#44; and physical parameters was carried out using two clinical-functional scores&#58; KOOS &#40;Knee Injury and Osteoarthritis Outcome Score&#41; &#8210; a clinical scale with 5 subsections ranging from 0 &#40;worst situation&#41; to 100 &#40;best situation&#41;&#59;<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> and KSS &#40;Knee Society Score System&#41; &#8210; a clinical scale&#44; ranging from 0 &#40;worst situation&#41; to 100 &#40;best situation&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0008"><span class="elsevierStyleSup">8</span></a></p><p id="para0016" class="elsevierStylePara elsevierViewall">Radiographic analysis was carried out based on full-limb and knee radiographs&#44; including an anteroposterior weight-bearing view&#44; a lateral view with 30&#176; of flexion&#44; and a skyline view&#46; The radiographs were classified by an orthopedic knee surgeon using the Kellgren-Lawrence system &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>&#41;&#44; which is an ordinal scale graded from 0 &#40;absence of radiographic features of osteoarthritis&#41; to 4 &#40;large osteophytes&#44; pronounced joint space narrowing&#44; severe sclerosis and defined bone deformity&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0009"><span class="elsevierStyleSup">9</span></a></p><elsevierMultimedia ident="fig0001"></elsevierMultimedia><span id="sec0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0010">Statistical analysis</span><p id="para0017" class="elsevierStylePara elsevierViewall">Qualitative variables were presented as absolute frequencies and percentages&#46; For quantitative variables&#44; the mean&#44; median&#44; standard deviation&#44; minimum value&#44; and maximum value were calculated&#46; Correlation coefficients between clinical scores and radiographic classification were obtained using Kendall&#39;s tau test &#40;&#964;-Kendall&#41;&#44; whose values may vary between -1 and &#43;1&#46; A positive value means that variables have a direct relationship&#44; a negative value means that the variables are inversely related&#44; and zero means there is no correlation between the two variables&#46; The strength of the correlation increases both from 0 to &#43;1&#44; and from 0 to -1&#46; The values of &#43;1 or -1 mean a perfect correlation&#46;<a class="elsevierStyleCrossRef" href="#bib0018"><span class="elsevierStyleSup">18</span></a></p><p id="para0018" class="elsevierStylePara elsevierViewall">The analysis was performed using the statistical software SPSS v&#46;25 for Windows&#46;</p></span></span><span id="sec0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0011">Results</span><p id="para0019" class="elsevierStylePara elsevierViewall">In total&#44; 120 patients &#40;189 knees&#41; were included in the analysis&#46; The mean age was 64 years &#40;34 to 98 years&#41;&#44; with the majority being female &#40;65&#37;&#41;&#46; The mean BMI was 30&#46;3 kg&#47;cm<span class="elsevierStyleSup">2</span>&#46; Systemic arterial hypertension was the most common comorbidity &#40;49&#46;1&#37;&#41;&#44; followed by diabetes mellitus &#40;16&#46;6&#37;&#41;&#46; 57&#46;5&#37; of patients had bilateral gonarthrosis&#46; Epidemiological characteristics and most common comorbidities were described in <a class="elsevierStyleCrossRef" href="#tbl0001">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0001"></elsevierMultimedia><p id="para0020" class="elsevierStylePara elsevierViewall">The mean and standard deviation values of the clinical scores according to their distributions in the Kellgren-Lawrence classification are presented in <a class="elsevierStyleCrossRef" href="#tbl0002">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0002"></elsevierMultimedia><p id="para0021" class="elsevierStylePara elsevierViewall">A weak negative correlation was observed between all clinical scores and radiographic classification&#44; and the results were statistically significant under the null hypothesis&#46; The clinical score with the strongest negative correlation was the KSS &#40;&#964; &#61; -0&#46;356&#59; p &#60; 0&#46;001&#41; and the weakest negative correlation was the KOOS-sport and recreation function &#40;&#964; &#61; -0&#46;142&#59; p &#61; 0&#46;025&#41;&#46; Test results demonstrating correlations between clinical scores and radiographic classification are presented in <a class="elsevierStyleCrossRef" href="#tbl0003">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0003"></elsevierMultimedia><p id="para0022" class="elsevierStylePara elsevierViewall">The distribution of patients between KSS and total KOOS scores according to the radiographic classification are summarized in the following box plots &#40;<a class="elsevierStyleCrossRef" href="#fig0002">Figs&#46; 2</a> and <a class="elsevierStyleCrossRef" href="#fig0003">3</a>&#41;</p><elsevierMultimedia ident="fig0002"></elsevierMultimedia><elsevierMultimedia ident="fig0003"></elsevierMultimedia></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0012">Discussion</span><p id="para0023" class="elsevierStylePara elsevierViewall">This study intended to evaluate TKA candidates and correlate their clinical scores with their radiographic classifications&#44; a fact that had not been previously reported in the literature&#44; in addition to carrying out an epidemiological analysis of the population&#46;</p><p id="para0024" class="elsevierStylePara elsevierViewall">In the sample analyzed&#44; the authors found epidemiological data that are similar to those previously described&#44; with a mean age of 64&#46;1 years and a female predominance &#40;65&#37;&#41;&#46; In the literature&#44; knee osteoarthritis is found with a frequency of up to 13&#37; in the population aged 60 years or over and is more prevalent in women than in men in the elderly population&#46;<a class="elsevierStyleCrossRef" href="#bib0019"><span class="elsevierStyleSup">19</span></a> In the present study&#44; obesity proved to be very prevalent&#44; being present in 50&#37; of cases&#46; There is also a high prevalence of systemic arterial hypertension &#40;52&#46;7&#37;&#41; and diabetes mellitus &#40;17&#46;9&#37;&#41;&#46; These findings are in accordance with previous literature&#44; in which higher grades in the Ahlb&#228;ck radiographic classification<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">20</span></a> were associated with the occurrence of systemic arterial hypertension&#44; and had a weak correlation with the patient&#39;s height and weight&#44; but moderate correlation with BMI&#46;<a class="elsevierStyleCrossRef" href="#bib0021"><span class="elsevierStyleSup">21</span></a> Furthermore&#44; patients with knee osteoarthritis at Kellgren-Lawrence Grade 2 or above have a higher prevalence of metabolic syndrome&#44; diabetes&#44; and hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0022"><span class="elsevierStyleSup">22</span></a></p><p id="para0025" class="elsevierStylePara elsevierViewall">When comparing the mean functional scores reported in this study with those described in the literature&#44; the scores in this cohort were significantly lower&#44; even in the moderate radiographic grades&#46; In a population study that evaluated 981 patients with knee osteoarthritis&#44; a mean total KOOS of 55&#46;33 was found with a standard deviation of &#177; 20&#46;641&#46;<a class="elsevierStyleCrossRef" href="#bib0023"><span class="elsevierStyleSup">23</span></a> In this study&#44; patients with Kellgren-Lawrence Grade 2 had a mean total KOOS of 31&#46;87&#44; Grade 3 of 22&#46;65&#44; and Grade 4 of 21&#46;45&#46; These lower clinical score values reported are probably due to the fact that only patients with surgical indications were included in this study&#44; which infers that they have more significant symptoms&#46;</p><p id="para0026" class="elsevierStylePara elsevierViewall">Regarding the clinical-radiographic correlation&#44; a weak and inversely proportional correlation was observed between all clinical scores analyzed&#44; including the subitems&#44; and the Kellgren-Lawrence classification&#46; As described in <a class="elsevierStyleCrossRef" href="#tbl0003">Table 3</a>&#44; all correlation values between the scores and the radiographic classification were negative&#44; denoting an inversely proportional correlation between these variables&#44; and result values are closer to zero than to -1&#44; denoting a weak correlation&#46; Among clinical scores evaluated&#44; KSS showed the highest correlation with the Kellgren-Lawrence classification &#40;&#964; &#61; -0&#46;356&#59; p &#60; 0&#46;001&#41;&#44; followed by KOOS-quality of life &#40;&#964; &#61; -0&#46;176&#59; p &#61; 0&#46;004&#41;&#44; KOOS-total score &#40;&#964;&#61;-0&#46;166&#59; p &#61; 0&#46;004&#41;&#44; KOOS-function in daily living &#40;&#964; &#61; -0&#46;160&#59; p &#61; 0&#46;005&#41; and KOOS-symptoms &#40;&#964; &#61; -0&#46;159&#59; p &#61; 0&#46;006&#41;&#46; KOOS-pain &#40;&#964; &#61; -0&#46;149&#59; p &#61; 0&#46;01&#41; and KOOS-sport and recreation function &#40;&#964; &#61; -0&#46;142&#59; p &#61; 0&#46;025&#41; scores had the weakest correlations&#46;</p><p id="para0027" class="elsevierStylePara elsevierViewall">Therefore&#44; although radiographic classification is an important parameter in the assessment of patients with knee osteoarthritis&#44; its correlation with the clinical presentation proved to be weak and not very consistent&#46; These findings corroborate previous literature&#44; which shows that the prevalence of pain is greater as radiographic osteoarthritis worsens&#44;<a class="elsevierStyleCrossRef" href="#bib0024"><span class="elsevierStyleSup">24</span></a> and that these variables present themselves as cause and consequence&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">25</span></a> but neither the intensity of pain nor the worsening of other symptoms were consistently associated with radiographic changes&#46;<a class="elsevierStyleCrossRef" href="#bib0026"><span class="elsevierStyleSup">26</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0027"><span class="elsevierStyleSup">27</span></a> Other biological&#44; psychological&#44; and social factors probably influence the diverse symptoms of osteoarthrosis and the radiographic worsening is not necessarily decisive in the functional worsening of patients&#46;</p><p id="para0028" class="elsevierStylePara elsevierViewall">Among the limitations of the study are the low reproducibility between observers and the lack of intra-observer uniformity of the Kellgren-Lawrence classification&#46;<a class="elsevierStyleCrossRef" href="#bib0028"><span class="elsevierStyleSup">28</span></a> Another point is the fact that the Kellgren-Lawrence classification limits the final stage of the disease to Stage 4&#46; However&#44; in the analysis with MRI&#44; a progression of the disease is still seen in patients classified as Stage 4&#44; with worsening of cartilage damage&#44; especially in the less affected tibiofemoral compartment&#44; with fluctuations in bone marrow edema and synovitis&#46; Despite this&#44; Kellgren-Lawrence grades in plain radiographs were highly correlated with the MRI grades&#46;<a class="elsevierStyleCrossRef" href="#bib0029"><span class="elsevierStyleSup">29</span></a> However&#44; it is noteworthy that the diagnosis of knee osteoarthrosis is more sensitive with the use of MRI than with the Kellgren-Lawrence scale&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">30</span></a> As described for the Ahlb&#228;ck classification&#44; the Kellgren-Lawrence classification should not be used routinely without the aid of adequate clinical assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0031"><span class="elsevierStyleSup">31</span></a></p></span><span id="sec0006" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0013">Conclusion</span><p id="para0029" class="elsevierStylePara elsevierViewall">The present study concludes that there is a weak correlation between the severity of radiographic changes and clinical symptoms in candidates for TKA&#46; Among clinical scores&#44; the objective KSS had the highest correlation with radiographic severity&#46;</p></span><span id="sec0007" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0014">Authors&#8217; contributions</span><p id="para0030" class="elsevierStylePara elsevierViewall">Diego Ubrig Munhoz&#58; Conceptualization&#59; methodology&#59; investigation&#59; data curation&#59; writing-original draft&#46;</p><p id="para0031" class="elsevierStylePara elsevierViewall">Andre Giardino Moreira da Silva&#58; Conceptualization&#59; methodology&#59; investigation&#59; data curation&#59; writing-original draft&#46;</p><p id="para0032" class="elsevierStylePara elsevierViewall">Pedro Nogueira Giglio&#58; Methodology&#59; data curation&#59; formal analysis&#46;</p><p id="para0033" class="elsevierStylePara elsevierViewall">Camilo Partezani Helito&#58; Methodology&#59; supervision&#59; project administration&#46;</p><p id="para0034" class="elsevierStylePara elsevierViewall">Riccardo Gomes Gobbi&#58; Conceptualization&#59; supervision&#59; project administration&#46;</p><p id="para0035" class="elsevierStylePara elsevierViewall">Lu&#237;s Eduardo Passarelli Tirico&#58; Conceptualization&#59; writing-review &#38; editing&#59; supervision&#59; project administration&#46; All authors read and approved the final manuscript&#46;</p></span><span id="sec0008" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0015">Ethics approval</span><p id="para0036" class="elsevierStylePara elsevierViewall">This study was performed in line with the principles of the Declaration of Helsinki&#46; Approval was granted by the Ethics Committee of the University of S&#227;o Paulo &#40;CAAE 08496919&#46;5&#46;0000&#46;0068&#59; 15&#47;04&#47;2019&#41;&#46;</p></span></span>"
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      "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><p id="spara009" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="celist0001"><li class="elsevierStyleListItem" id="celistitem0001"><span class="elsevierStyleLabel">&#8226;</span><p id="para0001" class="elsevierStylePara elsevierViewall">Knee osteoarthritis is a common joint disease&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0002"><span class="elsevierStyleLabel">&#8226;</span><p id="para0002" class="elsevierStylePara elsevierViewall">Total Knee Arthroplasty &#40;TKA&#41; is the gold standard surgical treatment after failed conservative management&#46;</p></li><li class="elsevierStyleListItem" id="celistitem0003"><span class="elsevierStyleLabel">&#8226;</span><p id="para0003" class="elsevierStylePara elsevierViewall">There is a weak correlation between radiographic worsening and functional impairment in patients with knee osteoarthritis and indication for TKA&#46;</p></li></ul></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Objective</span><p id="spara010" class="elsevierStyleSimplePara elsevierViewall">The objective of this study is to correlate clinical symptoms and functionality&#44; using the KOOS &#40;Knee Injury and Osteoarthritis Outcome Score&#41; and KSS &#40;Knee Society Score System&#41; scores&#44; with the radiographic changes&#44; using the Kellgren-Lawrence classification&#44; in patients with knee osteoarthritis and indications for Total Knee Arthroplasty &#40;TKA&#41;&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Methods</span><p id="spara011" class="elsevierStyleSimplePara elsevierViewall">120 patients &#40;189 knees&#41; with gonarthrosis and indications for TKA were included in the study&#46; Demographic questionnaires were applied&#44; and clinical and functional assessment was carried out using the KOOS and KSS scores&#46; Knee radiographs were taken and graded according to Kellgren-Lawrence&#46; The clinical scores were compared with the radiographic classification to establish a correlation between these two measurements&#46; Statistical analysis was performed using the &#964;-Kendall correlation test&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0005">Results</span><p id="spara012" class="elsevierStyleSimplePara elsevierViewall">Weak and inversely proportional correlations were found between the clinical scores and the radiographic classification&#46; Among clinical scores evaluated&#44; KSS showed the highest correlation with Kellgren-Lawrence classification &#40;&#964; &#61; -0&#46;356&#59; p &#60; 0&#46;001&#41;&#44; followed by KOOS-quality of life &#40;&#964; &#61; -0&#46;176&#59; p &#61; 0&#46;004&#41;&#44; KOOS-total score &#40;&#964; &#61; -0&#46;166&#59; p &#61; 0&#46;004&#41;&#44; KOOS-function in daily living &#40;&#964; &#61; -0&#46;160&#59; p &#61; 0&#46;005&#41; and KOOS-symptoms &#40;&#964; &#61; -0&#46;159&#59; p &#61; 0&#46;006&#41;&#46; KOOS-pain &#40;&#964; &#61; -0&#46;149&#59; p &#61; 0&#46;01&#41; and KOOS-sport and recreation function &#40;&#964; &#61; -0&#46;142&#59; p &#61; 0&#46;025&#41; scores had the weakest correlations&#46;</p></span> <span id="abss0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0006">Conclusion</span><p id="spara013" class="elsevierStyleSimplePara elsevierViewall">There is a weak correlation between the clinical-functional scores of TKA candidates and their radiographic classification by Kellgren-Lawrence&#46; Among clinical scores evaluated&#44; KSS had the strongest negative correlation with the radiographic classification&#46;</p></span>"
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          "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Knee radiographs classified by Kellgren-Lawrence system&#46; &#40;A&#41; Kellgren-Lawrence 1 &#40;doubtful joint space narrowing and possible osteophytic lipping&#41;&#59; &#40;B&#41; Kellgren-Lawrence 2 &#40;definite osteophytes and possible joint space narrowing&#41;&#59; &#40;C&#41; Kellgren-Lawrence 3 &#40;moderate multiple osteophytes&#44; definite narrowing of joint space&#44; some sclerosis and possible deformity of bone ends&#41;&#59; &#40;D&#41; Kellgren-Lawrence 4 &#40;large osteophytes&#44; marked narrowing of joint space&#44; severe sclerosis&#44; and definite deformity of bone ends&#41;&#46;</p>"
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col">Characteristic&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="top">64&#46;1 &#40;9&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">64 &#40;34&#8210;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0013"></a><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Gender</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="top">Female&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">78 &#40;65&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0020"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0022"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">42 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0023"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Weight &#40;kg&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">77&#46;9 &#40;15&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0028"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">78 &#40;48&#8210;140&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0029"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Height &#40;cm&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0030"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0031"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">160&#46;7 &#40;9&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0032"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">160 &#40;142&#8210;180&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0033"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0034"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">30&#46;3 &#40;5&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0036"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">30&#46;1 &#40;20&#46;7&#8210;49&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0037"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Smoking</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">9 &#40;7&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0039"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0040"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0041"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0042"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">20 &#40;16&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0043"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0044"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0045"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Arterial hypertension</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0046"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">59 &#40;49&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0047"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0048"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0049"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Dyslipidemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0050"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">11 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0051"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0052"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0053"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Thyroid disorder</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0054"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">12 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0055"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0056"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0057"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Depression</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">5 &#40;4&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0059"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0060"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0061"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Coronary disease</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">5 &#40;4&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0063"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0064"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0065"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Heart Failure</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0066"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">10 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0067"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0068"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0069"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Rheumatoid arthritis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0070"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">15 &#40;12&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0071"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0072"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0073"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top"><span class="elsevierStyleItalic">Knee osteoarthritis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0074"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0075"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0076"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0077"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">Right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0078"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">27 &#40;22&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0079"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0080"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0081"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0082"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">24 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0083"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0084"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0085"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">Bilateral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0086"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">69 &#40;57&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0087"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0088"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Epidemiological characteristics of patients with knee osteoarthritis&#46;</p>"
        ]
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      4 => array:8 [
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        "tabla" => array:2 [
          "leyenda" => "<p id="spara007" class="elsevierStyleSimplePara elsevierViewall">SD&#44; Standard Deviation&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0089"></a><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowgroup " rowspan="2" align="left" valign="top" scope="col">Clinical score</th><a name="en0090"></a><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Kellgren-Lawrence classification</th></tr><tr title="table-row"><a name="en0092"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col">Grade 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0093"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col">Grade 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0094"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col">Grade 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><a name="en00d96"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0096"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">n &#61; 45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0097"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">n &#61; 62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0098"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">n&#61;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0099"></a><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">KSS</span></td></tr><tr title="table-row"><a name="en0100"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0101"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">42&#46;7 &#40;19&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0102"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">30&#46;7 &#40;20&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0103"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">18&#46;9 &#40;18&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0104"></a><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">KOOS total</span></td></tr><tr title="table-row"><a name="en0105"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0106"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">31&#46;9 &#40;18&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0107"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">22&#46;7 &#40;16&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0108"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">21&#46;5 &#40;16&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0109"></a><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">KOOS-pain</span></td></tr><tr title="table-row"><a name="en0110"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0111"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">35&#46;3 &#40;20&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0112"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">24&#46;7 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0113"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">24&#46;8 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0114"></a><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">KOOS-symptoms</span></td></tr><tr title="table-row"><a name="en0115"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0116"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">40 &#40;20&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0117"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">33 &#40;19&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0118"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">29&#46;6 &#40;21&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0119"></a><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">KOOS-function in daily living</span></td></tr><tr title="table-row"><a name="en0120"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0121"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">34&#46;3 &#40;21&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0122"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">23&#46;2 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0123"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">22&#46;7 &#40;20&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0124"></a><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">KOOS-sport and recreation function</span></td></tr><tr title="table-row"><a name="en0125"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0126"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">12&#46;4 &#40;15&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0127"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">7&#46;2 &#40;12&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0128"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">5&#46;6 &#40;9&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0129"></a><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="top"><span class="elsevierStyleBold">KOOS-quality of life</span></td></tr><tr title="table-row"><a name="en0130"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0131"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">23&#46;9 &#40;20&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0132"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">15 &#40;18&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0133"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">13&#46;9 &#40;16&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spara006" class="elsevierStyleSimplePara elsevierViewall">Mean and standard deviation of clinical scores according to Kellgren-Lawrence classification in TKA candidates&#46;</p>"
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      ]
      5 => array:8 [
        "identificador" => "tbl0003"
        "etiqueta" => "Table 3"
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        "detalles" => array:1 [
          0 => array:3 [
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            "detalle" => "Table "
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        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><a name="en0134"></a><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowgroup " align="left" valign="top" scope="col">Clinical score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0135"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">Kellgren-Lawrence classification&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0136"></a><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowgroup " align="left" valign="top" scope="col">p-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><a name="en0138a"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0138"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&#964;-Kendall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><a name="en0138aa"></a><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><a name="en0140"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">KSS score objetivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0141"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">-0&#46;356&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0142"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0143"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">KOOS score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0144"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">-0&#46;166&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0145"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0146"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">KOOS-pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0147"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">-0&#46;149&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0148"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0149"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">KOOS-symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0150"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">-0&#46;159&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><a name="en0151"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="top">0&#46;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><a name="en0152"></a><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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Article information

ISSN: 18075932
Original language: English

DOI:10.1016/j.clinsp.2024.100503

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