Changes in fluconazole pharmacokinetics can impact on antifungal effectiveness in critically ill burn patients: a Pharmacokinetic-Pharmacodynamic (PK/PD) approach Victor Kaneko Matsuno; Edvaldo Vieira de Campos; Elson Mendes da Silva Junior; João Manoel da Silva Junior; David de Souza Gomez; Silvia Regina Cavani Jorge Santos;