Article information
Objetivo
Efectuar una puesta al día de las recomendaciones sobre el tratamiento antirretroviral (TAR) para los adultos infectados por el virus de la inmunodeficiencia humana (VIH).
MétodosEstas recomendaciones se han consensuado por un comité del Grupo de Estudio de Sida (GESIDA) y del Plan Nacional sobre el Sida (PNS). Para ello, se han revisado los avances en la fisiopatología del VIH, los resultados de eficacia y seguridad de ensayos clínicos, estudios de cohortes y de farmacocinética, publicados en revistas biomédicas o presentados en congresos en los últimos años. Se han definido tres niveles de evidencia según la procedencia de los datos: estudios aleatorizados (nivel A), de cohortes o de caso-control (nivel B) u opinión de expertos (nivel C). En cada una de las situaciones se ha establecido recomendar, considerar o no recomendar el TAR.
ResultadosEn el momento actual, el TAR con combinaciones de al menos 3 fármacos constituye el tratamiento de elección de la infección crónica por el VIH. En los pacientes con una infección por VIH sintomática se recomienda iniciar el TAR. En los pacientes asintomáticos el inicio de TAR se basará en la cifra de linfocitos CD4+/μl y en la carga viral plasmática (CVP): a) en pacientes con linfocitos CD4+< 200 cél./μl se recomienda iniciar el TAR; b) en pacientes con linfocitos CD4+entre 200 y 350 cél./μl en la mayoría de las ocasiones se debe recomendar el inicio de TAR; si bien se podría diferir cuando la cifra de linfocitos CD4+ se mantiene próxima a 350 cél./μl y la CVP es baja; c) en los pacientes con linfocitos CD4+> 350 cél./μl se puede diferir el inicio del TAR. El objetivo del TAR es lograr una CVP indetectable. La adherencia al TAR tiene un papel en la durabilidad de la respuesta antiviral. Las opciones terapéuticas en los fracasos del TAR son limitadas por la aparición de resistencias cruzadas. Los estudios genotípicos en estos casos son de utilidad. La toxicidad es un factor limitante del TAR. También se discuten los criterios de TAR de la infección aguda, embarazo y profilaxis postexposición, y el manejo de la coinfección por el VIH y los virus de las hepatitis B y C (VHC y VHB).
ConclusionesEn la actualidad existe una actitud más conservadora para iniciar el TAR que en recomendaciones previas. La cifra de linfocitos CD4+ es el factor de referencia más importante para iniciar el TAR en pacientes asintomáticos. Por otra parte, el número considerable de fármacos disponibles, los métodos de monitorización más sensibles (CVP) y la posibilidad de determinar las resistencias hacen que las estrategias terapéuticas sean mucho más individualizadas.
Palabras clave:
Tratamiento antiretroviral
VIH
Sida
Gesida
Plan Nacional sobre el SIDA
Recomendaciones
Resistencias
Prevención
Coinfección VIH y VHC o VHB
Objective
To provide an update of recommendation on antiretroviral treatment (ART) in HIV-infected adults.
MethodsThese recommendations have been agreed by consensus by a committee of the spanish AIDS Study Group (GESIDA) and the National AIDS Plan. To do so, advances in the physiopathology of AIDS and the results on efficacy and safety in clinical trials, cohort and pharmacokinetics studies published in biomedical journals or presented at congresses in the last few years have been reviewed. Three levels of evidence have been defined according to the data source: randomized studies (level A), case-control or cohort studies (level B) and expert opinion (level C). Whether to recommend, consider, or not to recommend ART has been established for each situation.
ResultsCurrently, ART with combinations of at least three drugs constitutes the treatment of choice in chronic HIV infection. In patients with symptomatic HIV infection, initiation of ART is recommended. In asymptomatic patients initiation of ART should be based on the CD4+/μL lymphocyte count and on the plasma viral load (PVL): a) in patients with CD4+ lymphocytes < 200 cells/μL, initiation of ART is recommended; b) in patients with CD4+ lymphocytes between 200 and 300 cells/μL, initiation of ART should, in most cases, be recommended; however, it could be delayed when the CD4+ lymphocyte count remains close to 350 cells/μL and the PVL is low, and c) in patients with CD4+ lymphocytes > 350 cells/μL, initiation of ART can be delayed. The aim of ART is to achieve an undetectable PVL. Adherence to ART plays a role in the durability of the antiviral response. Because of the development of cross-resistance, the therapeutic options in treatment failure are limited. In these cases, genotypic analysis is useful. Toxicity limits ART. The criteria for ART in acute infection, pregnancy and postexposure prophylaxis and in the management of coinfection with HIV and hepatitis C and B virus are controversial.
ConclusionsThe current approach to initiating ART is more conservative than in previous recommendations. In asymptomatic patients, the CD4+ lymphocyte count is the most important reference factor for initiating ART. Because of the considerable number of drugs available, more sensitive monitoring methods (PVL) and the possibility of determining resistance, therapeutic strategies have become much more individualized.
Key words:
Antiretroviral treatment
HIV
AIDS
GESIDA
National AIDS Plan
Recommendations
Resistance
Coinfection
HIV
hepatitis C
B virus
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Bibliografía
[1.]
Consejo Asesor Clínico del Plan Nacional sobre el SIDA. Tratamiento antirretroviral del adulto (1.a ed.). de Sanidad y Consumo. Ministerio.
Madrid, 3 (1995), pp. 1-12
[2.]
Consejo Asesor Clínico del Plan Nacional sobre el SIDA. Tratamiento antirretroviral del adulto (4.a ed.). de Sanidad y Consumo. Ministerio.
Madrid, 10 (1997), pp. 1-16
[4.]
S. Moreno, J. Arrizabalaga, J.J. Gatell, B. Clotet, K. Aguirrebengoa, A. Antela, et al.
Recomendaciones sobre tratamiento antirretroviral.
Med Clin (Barc), 110 (1998), pp. 109-116
[5.]
J.M. Miro, A. Antela, J. Arrizabalaga, B. Clotet, J.M. Gatell, L. Guerra, et al.
Recomendaciones de GESIDA/Plan Nacional sobre el SIDA respecto al tratamiento antirretroviral en pacientes adultos infectados por el virus de la inmunodeficiencia humana en el año 2000 (I).
Enferm Infecc Microbiol Clin, 18 (2000), pp. 51-329
[6.]
J.M. Miro, A. Antela, J. Arrizabalaga, B. Clotet, J.M. Gatell, L. Guerra, et al.
Recomendaciones de GESIDA/Plan Nacional sobre el SIDA respecto al tratamiento antirretroviral en pacientes adultos infectados por el virus de la inmunodeficiencia humana en el año 2000 (II).
Enferm Infecc Microbiol Clin, 18 (2000), pp. 396-412
[7.]
C.C. Carpenter, D.A. Cooper, M.A. Fischl, J.M. Gatell, B.G. Gazzard, S.M. Hammer, et al.
Antiretroviral therapy in adults: Updated recommendations of the International AIDS Society-USA Panel.
JAMA, 283 (2000), pp. 90-381
[8.]
Panel on Clinical Practices for Treatment of HIV. Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents. February 4, 2002 (the Living Document): HIV/AIDS Treatment Information Service, 2002. Disponible en; http://www.hivatis.org.
[9.]
BHIVA Writing Committee on behalf of the BHIVA Executive Committee. British HIV Association (BHIVA) for the treatment of HIV-infected adults with antiretroviral therapy. guidelines.
HIV Med, 2 (2001), pp. 276-313
[10.]
D. Finzi, J. Blankson, J.D. Siliciano, J.B. Margolick, K. Chadwick, T. Pierson, et al.
Latent infection of CD4 + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.
Nat Med, 5 (1999), pp. 7-512
[11.]
B. Autran, G. Carcelain, T.S. Li, C. Blanc, D. Mathez, R. Tubiana, et al.
Positive effects of combined antiretroviral therapy on CD4 + T cell homeostasis and function in advanced HIV disease.
Science, 277 (1997), pp. 112-116
[12.]
A. Carr, K. Samaras, A. Thorisdottir, G.R. Kaufmann, D.J. Chisholm, D.A. Cooper.
Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: A cohort study.
Lancet, 353 (1999), pp. 2093-2099
[13.]
H. Knobel, C. Codina, J.M. Miro, A. Carmona, B. Garcia, A. Antela, et al.
Recomendaciones GESIDA/SEFH/PNS para mejorar la adherencia al tratamiento antirretroviral.
Enferm Infecc Microbiol Clin, 18 (2000), pp. 27-39
[14.]
J.M. Gatell, J.L. Blanco, J. Alcami, A. Antela, J. Arrizabalaga, J.L. Casado, et al.
Documento de consenso de GESIDA sobre la utilización de los estudios de resistencias en la práctica clínica.
Enferm Infecc Microbiol Clin, 19 (2001), pp. 53-60
[15.]
J.A. Iribarren, J.T. Ramos, L. Guerra, O. Coll, M.I. de Jose, P. Domingo, et al.
Prevención de la transmisión vertical y tratamiento de la infección por VIH en la mujer embarazada. Recomendaciones de GESIDA-SEIMC, Asociación Española de Pediatría (AEP), Plan Nacional sobre el Sida y Sociedad Española de Ginecología y Obstetricia (SEGO.
Enferm Infecc Microbiol Clin, 19 (2001), pp. 314-335
[16.]
Almeda J, Casabona J. Grupo de Estudio Ceescat/Gesida/Plan Nacional: Guía de actuación para la profilaxis post-exposición no ocupacional al VIH, 2000. Disponible en: http://www.msc.es/sida.
[17.]
G. Guyatt, D. Rennie.
Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice.
[18.]
A.J. Jovell, M.D. Navarro-Rubio.
Evaluación de la evidencia científica.
Med Clin (Barc), 105 (1995), pp. 740-743
[19.]
L. Guerra Romero.
La medicina basada en la evidencia: un intento de acercar la ciencia al arte de la práctica clínica.
Med Clin (Barc), 107 (1996), pp. 377-382
[20.]
L. Guerra Romero, K. Stanley, F. Parras Vázquez.
La historia natural de los antirretrovirales: el continuum de su evaluación.
Med Clin (Barc), 112 (1999), pp. 59-66
[21.]
M.A. Fischl, D.D. Richman, M.H. Grieco, M.S. Gottlieb, P.A. Volberding, O.L. Laskin, et al.
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
N Engl J Med, 317 (1987), pp. 185-191
[22.]
Delta: A randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals.
Lancet, 348 (1996), pp. 283-291
[23.]
S.M. Hammer, D.A. Katzenstein, M.D. Hughes, H. Gundacker, R.T. Schooley, R.H. Haubrich, et al.
A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. AIDS Clinical Trials Group Study 175 Study Team.
N Engl J Med, 335 (1996), pp. 1081-1090
[24.]
S.M. Hammer, K.E. Squires, M.D. Hughes, J.M. Grimes, L.M. Demeter, J.S. Currier, et al.
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team.
N Engl J Med, 337 (1997), pp. 725-733
[25.]
D.W. Cameron, M. Heath-Chiozzi, S. Danner, C. Cohen, S. Kravcik, C. Maurath, et al.
Randomised placebo-controlled trial of ritonavir in advanced HIV-1 disease. The Advanced HIV Disease Ritonavir Study Group.
Lancet, 351 (1998), pp. 543-549
[26.]
Y. Mouton, S. Alfandari, M. Valette, F. Cartier, P. Dellamonica, G. Humbert, et al.
Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centres. Federation National des Centres de Lutte contre le SIDA.
AIDS, 11 (1997), pp. F101-F105
[27.]
R.A. Torres, M. Barr.
Impact of combination therapy for HIV infection on inpatient census.
N Engl J Med, 336 (1997), pp. 1531-1532
[28.]
F.J. Palella, K.M. Delaney, A.C. Moorman, M.O. Loveless, J. Fuhrer, G.A. Satten, et al.
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
N Engl J Med, 338 (1998), pp. 853-860
[29.]
S. Paul, H.M. Gilbert, W. Ziecheck, J. Jacobs, K.A. Sepkowitz.
The impact of potent antiretroviral therapy on the characteristics of hospitalized patients with HIV infection.
AIDS, 13 (1999), pp. 415-418
[30.]
A. Mocroft, S. Vella, T.L. Benfield, A. Chiesi, V. Miller, P. Gargalianos, et al.
Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group.
Lancet, 352 (1998), pp. 1725-1730
[31.]
J.C. Alberdi, D. Lopez-Gay, A. Ferreras, E. Nieto.
Descenso brusco de la mortalidad por VIH/SIDA en la Comunidad de Madrid.
Med Clin (Barc), 110 (1998), pp. 679
[32.]
D.A. Katzenstein, S.M. Hammer, M.D. Hughes, H. Gundacker, J.B. Jackson, S. Fiscus, et al.
The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team.
N Engl J Med, 335 (1996), pp. 1091-1098
[33.]
W.A. O’Brien, P.M. Hartigan, D. Martin, J. Esinhart, A. Hill, S. Benoit, et al.
Changes in plasma HIV-1 RNA and CD4 + lymphocyte counts and the risk of progression to AIDS. Veterans Affairs Cooperative Study Group on AIDS.
N Engl J Med, 334 (1996), pp. 426-431
[34.]
M.S. Hirsch, F. Brun-Vezinet, R.T. D’Aquila, S.M. Hammer, V.A. Johnson, D.R. Kuritzkes, et al.
Antiretroviral drug resistance testing in adult HIV-1 infection: Recommendations of an International AIDS Society-USA Panel.
JAMA, 283 (2000), pp. 2417-2426
[35.]
A.D. Kelleher, A. Carr, J. Zaunders, D.A. Cooper.
Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir.
J Infect Dis, 173 (1996), pp. 321-329
[36.]
B.F. Haynes, G. Pantaleo, A.S. Fauci.
Toward an understanding of the correlates of protective immunity to HIV infection.
Science, 271 (1996), pp. 324-358
[37.]
A. Carr, D.A. Cooper.
Adverse effects of antiretroviral therapy.
Lancet, 356 (2000), pp. 1423-1430
[38.]
P. Tebas, K. Henry, R. Nease, R. Murphy, J. Phair, W. Powderly.
Use of markov modeling and decision analysis to evaluate the long-term implications of antitretroviral therapy.
[39.]
M. Plana, F. Garcia, T. Gallart, J.M. Miro, J.M. Gatell.
Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease. Immunology Study Group of Spanish EARTH-1 Study.
Lancet, 352 (1998), pp. 1194-1195
[40.]
M.M. Kitahata, T.D. Koepsell, R.A. Deyo, C.L. Maxwell, W.T. Dodge, E.H. Wagner.
Physicians’ experience with the acquired immunodeficiency syndrome as a factor in patients’ survival.
N Engl J Med, 334 (1996), pp. 701-706
[41.]
J.M. Peña, J.M. Miro.
Restauración inmunológica en pacientes con sida. ¿Requiem por las profilaxis?.
Med Clin (Barc, 113 (1999), pp. 375-378
[42.]
K.A. Sepkowitz.
Effect of HAART on natural history of AIDS-related opportunistic disorders.
Lancet, 351 (1998), pp. 228-230
[43.]
M.A. Jacobson, M. Zegans, P.R. Pavan, J.J. O’Donnell, F. Sattler, N. Rao, et al.
Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy.
Lancet, 349 (1997), pp. 1443-1445
[44.]
E.M. Race, J. Adelson-Mitty, G.R. Kriegel, T.F. Barlam, K.A. Reimann, N.L. Letvin, et al.
Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease.
Lancet, 351 (1998), pp. 252-255
[45.]
C. Michelet, C. Arvieux, C. Francois, J.M. Besnier, J.P. Rogez, J.P. Breux, et al.
Opportunistic infections occurring during highly active antiretroviral treatment.
AIDS, 12 (1998), pp. 1815-1822
[46.]
B. Ledergerber, M. Egger, V. Erard, R. Weber, B. Hirschel, H. Furrer, et al.
AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: The Swiss HIV Cohort Study.
JAMA, 282 (1999), pp. 2220-2226
[47.]
T.S. Li, R. Tubiana, C. Katlama, V. Calvez, H. Ait Mohand, B. Autran.
Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease.
Lancet, 351 (1998), pp. 1682-1686
[48.]
S. Kostense, F.M. Raaphorst, D.W. Notermans, J. Joling, B. Hooibrink, N.G. Pakker, et al.
Diversity of the T-cell receptor BV repertoire in HIV-1-infected patients reflects the biphasic CD4 + T-cell repopulation kinetics during highly active antiretroviral therapy.
AIDS, 12 (1998), pp. F235-F240
[49.]
S.G. Deeks, F.M. Hecht, M. Swanson, T. Elbeik, R. Loftus, P.T. Cohen, et al.
HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: Response to both initial and salvage therapy.
AIDS, 13 (1999), pp. F35-F43
[50.]
S.G. Deeks, J.D. Barbour, J.N. Martin, M.S. Swanson, R.M. Grant.
Sustained CD4 + T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection.
J Infect Dis, 181 (2000), pp. 946-953
[51.]
D. Kaufmann, G. Pantaleo, P. Sudre, A. Telenti.
CD4+cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART). Swiss HIV Cohort Study.
Lancet, 351 (1998), pp. 723-724
[52.]
F. Garcia, C. Vidal, M. Plana, A. Cruceta, M.T. Gallart, T. Pumarola, et al.
Residual low-level viral replication could explain discrepancies between viral load and CD4+ cell response in human immunodeficiency virus-infected patients receiving antiretroviral therapy.
Clin Infect Dis, 30 (2000), pp. 392-394
[53.]
A. Moreno, M.J. Pérez Elías, F. Dronda, V. Muñoz, J.L. Casado, A. Antela, et al.
One-year rate and baseline predictors of discordant virological-immunological responses in naïve patients on HAART in the clinical setting.
[54.]
D. Brambilla, P.S. Reichelderfer, J.W. Bremer, D.E. Shapiro, R.C. Hershow, D.A. Katzenstein, et al.
The contribution of assay variation and biological variation to the total variability of plasma HIV-1 RNA measurements. The Women Infant Transmission Study Clinics. Virology Quality Assurance Program.
Aids, 13 (1999), pp. 2269-2279
[55.]
Anónimo. Guidelines for the performance of CD4+ T-cell determinations in persons with human immunodeficiency virus infection.
MMWR Recomm Rep, 41 (1992), pp. 1-17
[56.]
P.E. Sax, S.L. Boswell, M. White-Guthro, M.S. Hirsch.
Potential clinical implications of interlaboratory variability in CD4+ T-lymphocyte counts of patients infected with human immunodeficiency virus.
Clin Infect Dis, 21 (1995), pp. 1121-1125
[57.]
D.J. Kempf, R.A. Rode, Y. Xu, E. Sun, M.E. Heath-Chiozzi, J. Valdes, et al.
The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir.
AIDS, 12 (1998), pp. F9-14
[58.]
J.M. Raboud, J.S. Montaner, B. Conway, S. Rae, P. Reiss, S. Vella, et al.
Suppression of plasma viral load below 20 copies/ml is required to achieve a long-term response to therapy.
AIDS, 12 (1998), pp. 1619-1624
[59.]
L.M. Demeter, M.D. Hughes, R.W. Coombs, J.B. Jackson, J.M. Grimes, R.J. Bosch, et al.
Predictors of virologic and clinical outcomes in HIV-1-infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine. AIDS Clinical Trials Group Protocol 320.
Ann Intern Med, 135 (2001), pp. 954-964
[60.]
W. Huang, V. DeGruttola, M. Fischl, S. Hammer, D.D. Richman, D. Havlir, et al.
Patterns of Plasma HIV RNA Responses in Antiretroviral Treatment Success and Failure.
[61.]
M. King, B. Bernstein, D. Kempf, J. Moseley, K. Gu, E. Sun.
Comparison of time to achiev HIV RNA < 400 copies/mL and < 50 copies/mL in a phase III, blinded, randomized clinical trial of ABT-378/r vs. NFV in ARV-Naive Patients.
[62.]
H.F. Gunthard, J.K. Wong, C.C. Ignacio, J.C. Guatelli, N.L. Riggs, D.V. Havlir, et al.
Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy.
J Virol, 72 (1998), pp. 2422-2428
[63.]
D.V. Havlir, R. Bassett, D. Levitan, P. Gilbert, P. Tebas, A.C. Collier, et al.
Prevalence and predictive value of intermittent viremia with combination HIV therapy.
JAMA, 286 (2001), pp. 171-179
[64.]
G. Greub, A. Cozzi Lepri, B. Ledergerber, S. Staszewski, L. Perrin, V. Miller, et al.
Low-level HIV viral rebound and blips in patients receiving potent antiretroviral therapy.
[65.]
M.S. Saag, M. Holodniy, D.R. Kuritzkes, W.A. O’Brien, R. Coombs, M.E. Poscher, et al.
HIV viral load markers in clinical practice.
Nat Med, 2 (1996), pp. 625-629
[66.]
S.H. Khoo, S.E. Gibbons, D.J. Back.
Therapeutic drug monitoring as a tool in treating HIV infection.
AIDS, 15 (2001), pp. S171-S181
[67.]
J.M. Schapiro, M.A. Winters, F. Stewart, B. Efron, J. Norris, M.J. Kozal, et al.
The effect of high-dose saquinavir on viral load and CD4+T-cell counts in HIV-infected patients.
Ann Intern Med, 124 (1996), pp. 1039-1050
[69.]
M. Harris, C. Durakovic, S. Rae, J. Raboud, S. Fransen, A. Shillington, et al.
A pilot study of nevirapine, indinavir, and lamivudine among patients with advanced human immunodeficiency virus disease who have had failure of combination nucleoside therapy.
J Infect Dis, 177 (1998), pp. 1514-1520
[70.]
D.M. Burger, R.M. Hoetelmans, P.W. Hugen, J.W. Mulder, P.L. Meenhorst, P.P. Koopmans, et al.
Low plasma concentrations of indinavir are related to virological treatment failure in HIV-1-infected patients on indinavir-containing triple therapy.
Antivir Ther, 3 (1998), pp. 47-52
[71.]
J.L. Casado, S. Moreno, K. Hertogs, F. Dronda, A. Antela, P. Dehertogh, et al.
Plasma drug levels, genotypic resistance, and virological response to a nelfinavir plus saquinavir-containing regimen.
AIDS, 16 (2002), pp. 47-52
[72.]
R.M. Hoetelmans, M.H. Reijers, G.J. Weverling, R.W. ten Kate, F.W. Wit, J.W. Mulder, et al.
The effect of plasma drug concentrations on HIV-1 clearance rate during quadruple drug therapy.
AIDS, 12 (1998), pp. F111-F115
[73.]
G. Fatkenheuer, R.M. Hoetelmans, N. Hunn, A. Schwenk, C. Franzen, M. Reiser, et al.
Salvage therapy with regimens containing ritonavir and saquinavir in extensively pretreated HIV-infected patients.
AIDS, 13 (1999), pp. 1485-1489
[74.]
A.I. Veldkamp, G.J. Weverling, J.M. Lange, J.S. Montaner, P. Reiss, D.A. Cooper, et al.
High exposure to nevirapine in plasma is associated with an improved virological response in HIV-1-infected individuals.
AIDS, 15 (2001), pp. 1089-1095
[75.]
J.P. Dieleman, I.C. Gyssens, M.E. van der Ende, S. de Marie, D.M. Burger.
Urological complaints in relation to indinavir plasma concentrations in HIV-infected patients.
AIDS, 13 (1999), pp. 473-478
[76.]
C. Marzolini, A. Telenti, L.A. Decosterd, G. Greub, J. Biollaz, T. Buclin.
Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients.
AIDS, 15 (2001), pp. 71-75
[77.]
D. Gonzalez de Requena, M. Nunez, I. Jimenez-Nacher, V. Soriano.
Liver toxicity caused by nevirapine.
AIDS, 16 (2002), pp. 290-291
[78.]
D. Burger, P. Hugen, J. Droste, A. Huitema.
Therapeutic drug monitoring of nelfinavir and indinavir in treatment-naïve patients improves after 1 year: Results from ATHENA.
[79.]
P. Clevenbergh, J. Durant, R. Garraffo, M. Kirstetter, J.P. Daures, P. Dellamonica.
Usefulness of protease inhibitor therapeutic drug monitoring? PharmAdapt: A prospective multicentric randomized controlled trial: 12 weeks results.
[80.]
J.H. Condra, C.J. Petropoulos, R. Ziermann, W.A. Schleif, M. Shivaprakash, E.A. Emini.
Drug resistance and predicted virologic responses to human immunodeficiency virus type 1 protease inhibitor therapy.
J Infect Dis, 182 (2000), pp. 758-765
[81.]
D. Kempf, A. Hsu, P. Jiang, R. Rode, K. Hertogs, B. Larder, et al.
Response to ritonavir (RTV) intensification in indinavir (IDV) recipients is highly correlated with virtual inhibitory quotient.
[82.]
X. Duval, C. Lamotte, E. Race, D. Descamps, F. Damond, F. Clavel, et al.
Amprenavir inhibitory quotient and virological response in human immunodeficiency virus-infected patients on an amprenavir-containing salvage regimen without or with ritonavir.
Antimicrob Agents Chemother, 46 (2002), pp. 570-574
[83.]
J.W. Drake.
Rates of spontaneous mutation among RNA viruses.
Proc Natl Acad Sci U S A, 90 (1993), pp. 4171-4175
[84.]
J.W. Drake, B. Charlesworth, D. Charlesworth, J.F. Crow.
Rates of spontaneous mutation.
Genetics, 148 (1998), pp. 1667-1686
[85.]
L.M. Mansky, H.M. Temin.
Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.
J Virol, 69 (1995), pp. 5087-5094
[86.]
D.D. Ho, A.U. Neumann, A.S. Perelson, W. Chen, J.M. Leonard, M. Markowitz.
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.
Nature, 373 (1995), pp. 123-126
[87.]
X. Wei, S.K. Ghosh, M.E. Taylor, V.A. Johnson, E.A. Emini, P. Deutsch, et al.
Viral dynamics in human immunodeficiency virus type 1 infection.
Nature, 373 (1995), pp. 117-122
[88.]
J.M. Coffin.
HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy.
Science, 267 (1995), pp. 483-489
[89.]
A.S. Perelson, A.U. Neumann, M. Markowitz, J.M. Leonard, D.D. Ho.
HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time.
Science, 271 (1996), pp. 1582-1586
[90.]
S. Wain-Hobson.
Is antigenic variations of HIV important for AIDS and what might be expected in the future?.
The Evolutionary Biology of Viruses, pp. 185-209
[91.]
R. Schuurman, M. Nijhuis, R. van Leeuwen, P. Schipper, D. de Jong, P. Collis, et al.
Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC.
J Infect Dis, 171 (1995), pp. 1411-1419
[92.]
D.D. Richman.
Susceptibility to nucleoside analogues of zidovudine-resistant isolates of human immunodeficiency virus.
Am J Med, 88 (1990), pp. 8S-10S
[93.]
J.H. Condra, D.J. Holder, W.A. Schleif, O.M. Blahy, R.M. Danovich, L.J. Gabryelski, et al.
Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.
J Virol, 70 (1996), pp. 8270-8276
[94.]
A. Molla, M. Korneyeva, Q. Gao, S. Vasavanonda, P.J. Schipper, H.M. Mo, et al.
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir.
Nat Med, 2 (1996), pp. 760-766
[95.]
H.L. Devereux, M. Youle, M.A. Johnson, C. Loveday.
Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy.
AIDS, 13 (1999), pp. F123-F127
[96.]
A.M.J. Wensing, W. Keulen, M. Buimer, D. Brambilla, R. Schuurman, C. Boucher.
The ENVA-3 World Wide Evaluation Study Shows Extensive Differences in Interpretation on HIV-1 Genotype Analysis.
[97.]
S.H. Oari, R. Respess, H. Weinstock.
A comparative analysis of Virco antivirogram and virologic phenosense phenotypic assays for drug susceptibility of HIV-1. 4th International Workshop on Drug Resistance and Treatment Strategies; Sitges (Spain), 2000.
Antiviral Ther, 5 (2000), pp. 49-62
[98.]
B.A. Larder, S.D. Kemp, K. Hertogs.
Quantitative prediction of HIV-1 phenotypic drug resistance from genotypes: The virtual phenotype (VirtualPhenopyte), 4th International Workshop on Drug Resistance and Treatment Strategies, Sitges (Spain), 2000.
Antiviral Ther, 5 (2000), pp. 49-63
[99.]
J.M. Miró, T. Pumarola, F. García, M. Arnedo, C. Vidal, L. Lozano, et al.
Prevalence of transmission of HIV-1 drug resistant mutations in patients with primary HIV-1 infection in Barcelona (Spain).
[100.]
T. Puig, M. Perez-Olmeda, A. Rubio, L. Ruiz, C. Briones, J.M. Franco, et al.
Prevalence of genotypic resistance to nucleoside analogues and protease inhibitors in Spain. The ERASE-2 Study Group.
AIDS, 14 (2000), pp. 727-732
[101.]
M. Gomez-Cano, A. Rubio, T. Puig, M. Perez-Olmeda, L. Ruiz, V. Soriano, et al.
Prevalence of genotypic resistance to nucleoside analogues in antiretroviral-naive and antiretroviral-experienced HIV-infected patients in Spain.
AIDS, 12 (1998), pp. 1015-1020
[102.]
S. Yerly, L. Kaiser, E. Race, J.P. Bru, F. Clavel, L. Perrin.
Transmission of antiretroviral-drug-resistant HIV-1 variants.
Lancet, 354 (1999), pp. 729-733
[103.]
R.T. D’Aquila, V.A. Johnson, S.L. Welles, A.J. Japour, D.R. Kuritzkes, V. DeGruttola, et al.
Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy. AIDS Clinical Trials Group Protocol 116B/117 Team and the Virology Committee Resistance Working Group.
Ann Intern Med, 122 (1995), pp. 401-408
[104.]
A.J. Japour, S. Welles, R.T. D’Aquila, V.A. Johnson, D.D. Richman, R.W. Coombs, et al.
Prevalence and clinical significance of zidovudine resistance mutations in human immunodeficiency virus isolated from patients after long-term zidovudine treatment. AIDS Clinical Trials Group 116B/117 Study Team and the Virology Committee Resistance Working Group.
J Infect Dis, 171 (1995), pp. 1172-1179
[105.]
M.J. Kozal, R.W. Shafer, M.A. Winters, D.A. Katzenstein, E. Aguiniga, J. Halpern, et al.
HIV-1 syncytium-inducing phenotype, virus burden, codon 215 reverse transcriptase mutation and CD4 cell decline in zidovudine-treated patients.
J Acquir Immune Defic Syndr, 7 (1994), pp. 832-838
[106.]
D.V. Havlir, I.C. Marschner, M.S. Hirsch, A.C. Collier, P. Tebas, R.L. Bassett, et al.
Maintenance antiretroviral therapies in HIV infected patients with undetectable plasma HIV RNA after triple-drug therapy. AIDS Clinical Trials Group Study 343 Team.
Engl J Med, 339 (1998), pp. 1261-1268
[107.]
M.T. Huisman, J.W. Smit, A.H. Schinkel.
Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors.
AIDS, 14 (2000), pp. 237-242
[108.]
V. DeGruttola, L. Dix, R. D’Aquila, D. Holder, A. Phillips, M. Ait-Khaled, et al.
The relation between baseline HIV drug resistance and response to antiretroviral therapy: Re-analysis of retrospective and prospective studies using a standardized data analysis plan.
Antivir Ther, 5 (2000), pp. 41-48
[109.]
G.J. Hanna, R.T. D’Aquila.
Clinical use of genotypic and phenotypic drug resistance testing to monitor antiretroviral chemotherapy.
Clin Infect Dis, 32 (2001), pp. S51-S59
[110.]
R. Haubrich, L. Demeter, et al.
International perspectives on antiretroviral resistance. Clinical utility of resistance testing: Retrospective and prospective data supporting use and current recommendations.
J Acquir Immune Defic Syndr, 26 (2001), pp. S51-S59
[111.]
J. Durant, P. Clevenbergh, P. Halfon, P. Delgiudice, S. Porsin, P. Simonet, et al.
Drug-resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial.
Lancet, 353 (1999), pp. 2195-2199
[112.]
P. Clevenbergh, J. Durant, P. Halfon, P. del Giudice, V. Mondain, N. Montagne, et al.
Persisting long-term benefit of genotype-guided treatment for HIV-infected patients failing HAART. The Viradapt Study: Week 48 follow-up.
Antivir Ther, 5 (2000), pp. 65-70
[113.]
J.D. Baxter, D.L. Mayers, D.N. Wentworth, J.D. Neaton, M.L. Hoover, M.A. Winters, et al.
A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS.
AIDS, 14 (2000), pp. F83-F93
[114.]
C.J. Cohen, S. Hunt, M. Sension, C. Farthing, M. Conant, S. Jacobson, et al.
A randomized trial assessing the impact of phenotypic resistance testing on antiretroviral therapy.
AIDS, 16 (2002), pp. 579-588
[115.]
A. Cingolani, A. Antinori, M.G. Rizzo, R. Murri, A. Ammassari, F. Baldini, et al.
Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: A randomized study (ARGENTA.
AIDS, 16 (2002), pp. 369-379
[116.]
R. Haubrich, P. Keiser, C.A. Kemper, M.D. Witt, J. Leedom, D. Forthol.
CCTG 575: A randomized, prospective study of phenotype testing versus standard of care for patients failing antiretroviral therapy.
[117.]
J.L. Meynard, M. Vray, L. Morand-Joubert, E. Race, D. Descamps, G. Peytavin, et al.
Phenotypic or genotypic resistance testing for choosing antiretroviral therapy after treatment failure: A randomized trial.
AIDS, 16 (2002), pp. 727-736
[118.]
C. Tural, L. Ruiz, C. Holtzer, J. Schapiro, P. Viciana, J. Gonzalez, et al.
Clinical utility of HIV-1 genotyping and expert advice: The Havana trial.
AIDS, 16 (2002), pp. 209-218
[119.]
F. Mazzotta, S. Lo Caputo, L. Scudeller, C. Torti, F. Castelli, G. Carosi.
Real-vs-virtual phenotype: 16 week results of a multicentre randomised trial (The Genpherex study).
[120.]
M.J. Perez-Elias, I. Garcia-Arata, V. Muñoz, I. Santos, J. Sanz, V. Abraira, et al.
A Randomized, Prospective Study of Phenotype (P) versus Virtual Phenotype (VirtualP) Testing for Patients Failing Antiretroviral Therapy (ART).
[121.]
D. Torre, R. Tambini.
Antiretroviral drug resistance testing in patients with HIV-1 infection: A meta-analysis study.
HIV Clin Trials, 3 (2002), pp. 1-8
[122.]
L.M. Mofenson, J.S. Lambert, E.R. Stiehm, J. Bethel, W.A. Meyer, J. Whitehouse, et al.
Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team.
Engl J Med, 341 (1999), pp. 385-393
[123.]
S.L. Welles, J. Pitt, R. Colgrove, K. McIntosh, P.H. Chung, A. Colson, et al.
HIV-1 genotypic zidovudine drug resistance and the risk of maternal–infant transmission in the women and infants transmission study. The Women and Infants Transmission Study Group.
AIDS, 14 (2000), pp. 263-271
[124.]
Comisión asesora sobre resistencias a los antirretrovirales. Las resistencias a los fármacos antirretrovirales: utilización de los tests en la práctica asistencial. Informe de secretaría del Plan Nacional sobre el Sida. Disponible en; http://www.msc.es/sida/novedades/home.htm, 2000
[125.]
J.O. Kahn, B.D. Walker.
Acute human immunodeficiency virus type 1 infection.
Engl J Med, 339 (1998), pp. 33-39
[126.]
J. Stekler, A. Collier.
Treatment of Primary HIV.
Curr Infect Dis Rep, 4 (2002), pp. 81-87
[127.]
E.S. Daar, S. Little, J. Pitt, J. Santangelo, P. Ho, N. Harawa, et al.
Diagnosis of primary HIV-1 infection. Los Angeles County Primary HIV Infection Recruitment Network.
Ann Intern Med, 134 (2001), pp. 25-29
[128.]
S. Lindback, R. Thorstensson, A.C. Karlsson, M. von Sydow, L. Flamholc, A. Blaxhult, et al.
Diagnosis of primary HIV-1 infection and duration of follow-up after HIV exposure. Karolinska Institute Primary HIV Infection Study Group.
AIDS, 14 (2000), pp. 2333-2339
[129.]
D.E. Cohen, B.D. Walker.
Human immunodeficiency virus pathogenesis and prospects for immune control in patients with established infection.
Clin Infect Dis, 32 (2001), pp. 1756-1768
[130.]
A. Oxenius, S. Fidler, M. Brady, S.J. Dawson, K. Ruth, P.J. Easterbrook, et al.
Variable fate of virus-specific CD4(+) T cells during primary HIV-1 infection.
Eur J Immunol, 31 (2001), pp. 3782-3788
[131.]
A. Oxenius, S. Yerly, E. Ramirez, R.E. Phillips, D.A. Price, L. Perrin.
Distribution of functional HIV-specific CD8 T lymphocytes between blood and secondary lymphoid organs after 8-18 months of antiretroviral therapy in acutely infected patients.
AIDS, 15 (2001), pp. 1653-1656
[132.]
M. Altfeld, E.S. Rosenberg, R. Shankarappa, J.S. Mukherjee, F.M. Hecht, R.L. Eldridge, et al.
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
J Exp Med, 193 (2001), pp. 169-180
[133.]
E.S. Rosenberg, M. Altfeld, S.H. Poon, M.N. Phillips, B.M. Wilkes, R.L. Eldridge, et al.
Immune control of HIV-1 after early treatment of acute infection.
Nature, 407 (2000), pp. 523-526
[134.]
F. Lori, M.G. Lewis, J. Xu, G. Varga, D.E. Zinn, C. Crabbs, et al.
Control of SIV rebound through structured treatment interruptions during early infection.
Science, 290 (2000), pp. 1591-1593
[135.]
J. Miró, M. Plana, G.M. Ortiz, M.J. Maleno, M. Arnedo, A. del Rio, et al.
Structured treatment interruptions (STI) in patients receiving HAART since primary HIV-1 infection (PHI): Spontaneous control of viremia in about one third of cases after the first 3 cycles off therapy.
[136.]
L.E. Goh, L. Perrin, B. Hoen, D. Cooper, A. Phillips, G. Janossy, et al.
Study protocol for the evaluation of the potential for durable viral suppression after quadruple HAART with or without HIV vaccination: The QUEST study.
HIV Clin Trials, 2 (2001), pp. 438-444
[137.]
J. Miller, A. Carr, D. Smith, S. Emery, M.G. Law, P. Grey, et al.
Lipodystrophy following antiretroviral therapy of primary HIV infection.
AIDS, 14 (2000), pp. 2406-2407
[138.]
C. Goujard, F. Boufassa, C. Deveau, D. Laskri, L. Meyer.
Incidence of clinical lipodystrophy in HIV-infected patients treated during primary infection.
AIDS, 15 (2001), pp. 282-284
[139.]
P. Narciso, V. Tozzi, G. D’Offizi, G. De Carli, N. Orchi, V. Galati, et al.
Metabolic and morphologic disorders in patients treated with highly active antiretroviral therapy since primary HIV infection.
Ann N Y Acad Sci, 946 (2001), pp. 212-214
[140.]
J.W. Mellors, A. Munoz, J.V. Giorgi, J.B. Margolick, C.J. Tassoni, P. Gupta, et al.
Plasma viral load and CD4+lymphocytes as prognostic markers of HIV-1 infection.
Ann Intern Med, 126 (1997), pp. 946-954
[141.]
I.C. Marschner, A.C. Collier, R.W. Coombs, R.T. D’Aquila, V. DeGruttola, M.A. Fischl, et al.
Use of changes in plasma levels of human immunodeficiency virus type 1 RNA to assess the clinical benefit of antiretroviral therapy.
J Infect Dis, 177 (1998), pp. 40-47
[142.]
H. Farzadegan, D.R. Hoover, J. Astemborski, C.M. Lyles, J.B. Margolick, R.B. Markham, et al.
Sex differences in HIV-1 viral load and progression to AIDS.
Lancet, 352 (1998), pp. 1510-1514
[143.]
T.R. Sterling, C.M. Lyles, D. Vlahov, J. Astemborski, J.B. Margolick, T.C. Quinn.
Sex differences in longitudinal human immunodeficiency virus type 1 RNA levels among seroconverters.
J Infect Dis, 180 (1999), pp. 666-672
[144.]
A. Cozzi Lepri, A.N. Phillips, A. d’Arminio Monforte, F. Castelli, A. Antinori, A. de Luca, et al.
When to start highly active antiretroviral therapy in chronically HIV-infected patients: Evidence from the ICONA study.
AIDS, 15 (2001), pp. 983-990
[145.]
A.N. Phillips, S. Staszewski, R. Weber, O. Kirk, P. Francioli, V. Miller, et al.
HIV viral load response to antiretroviral therapy according to the baseline CD4 cell count and viral load.
JAMA, 286 (2001), pp. 2560-2567
[146.]
R.S. Hogg, B. Yip, K.J. Chan, E. Wood, K.J. Craib, M.V. O’Shaughnessy, et al.
Rates of disease progression by baseline CD4 cell count and viral load after initiating triple-drug therapy.
JAMA, 286 (2001), pp. 2568-2577
[147.]
J. Kaplan, D. Hanson, J. Karon, D. Cohn, M. Thompson, S. Buskin, et al.
Late initiation of antiretroviral therapy (at CD4 + Lymphocyte Count ‐ 200 Cells/mL) is associated with increased risk of death.
[148.]
T.R. Sterling, R.E. Chaisson, R.D. Moore.
HIV-1 RNA, CD4 T-lymphocytes, and clinical response to highly active antiretroviral therapy.
AIDS, 15 (2001), pp. 2251-2257
[149.]
M. Egger.
on behalf of the ART Cohort Collaboration (ART-CC). Prognosis of HIV-1 infected drug naïve patients starting potent antiretroviral therapy: Multicohort analysis of 12,040 patients.
[150.]
CDC. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults.
MMWR Recomm Rep, 41 (1992), pp. 1-19
[151.]
J.A. Bartlett, R. DeMasi, J. Quinn, C. Moxham, F. Rousseau.
Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults.
AIDS, 15 (2001), pp. 1369-1377
[152.]
S. Staszewski, J. Morales-Ramirez, K.T. Tashima, A. Rachlis, D. Skiest, J. Stanford, et al.
Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team.
Engl J Med, 341 (1999), pp. 1865-1873
[153.]
K. Squires.
The Atlantic Study: A randomized, open-label trial comparing two protease inhibitor (pi)-sparing anti-retroviral strategies versus a standard pi-containing regimen, final 48 week data.
[154.]
S. Staszewski, P. Keiser, J. Montaner, F. Raffi, J. Gathe, V. Brotas, et al.
Abacavir-lamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial.
JAMA, 285 (2001), pp. 1155-1163
[155.]
M. Nelson, S. Staszewski, J.O. Morales-Ramirez, C.B. Aguado, D.P. Palter, F. Milazzo, et al.
Successful virologic suppression with Efavirenz in HIV-infected patients with low baseline CD4 cell counts: Post hoc results from Study 006.
[156.]
F. Pulido, J.R. Arribas, J.M. Miró, A. Costa, R. Rubio, J. Gonzalez, et al.
Comparative study of efavirenz or protease inhibitor-based HAART in HIV-infected, antiretroviral naive patients with < 100 cel/μL and opportinistic diseases (EFAVIP-2 study).
[157.]
J.M. Gatell, B. Clotet, D. Podzamcer, J.M. Miró, J. Mallolas.
Guía práctica del SIDA. Clínica, diagnóstico y tratamiento.
[158.]
J.G. Bartlett.
The Johns Hopkins Hospital 2001-2002 Guide to Medical Care of Patients with HIV Infection.
[159.]
Peiperl L, Volberding P. HIV InSite Knowledge Base. University of California San Francisco and San Francisco General Hospital, 2002. Disponible en; http://hivinsite.ucsf.edu/InSite.jsp
[160.]
J.J. Eron, E.S. Yetzer, P.J. Ruane, S. Becker, G.A. Sawyer, R.L. Fisher, et al.
Efficacy, safety, and adherence with a twice-daily combination lamivudine/zidovudine tablet formulation, plus a protease inhibitor, in HIV infection.
AIDS, 14 (2000), pp. 671-681
[161.]
Pollard R, Ive P, Farthing C, Whelden M, Thompson S, Brett-Smith H. Stavudine XR vs Stavudine IR as Part of Potent Antiretroviral Combination Therapy: 24-Week Safety and Antiviral Efficacy. 9th Conference on Retroviruses and Opportunistic Infections, 2002. Resumen 411-W
[162.]
A. Vibhagool, P. Cahn, M. Schechter, L. Soto-Ramirez, M. Montroni, F. Smaill, et al.
Abacavir/Combivir (ABC/COM) is comparable to Indinvavir/Combivir in HIV-1 infected antiretroviral therapy naive adults: Preliminary results of a 48-week open label study (CNA3014).
[163.]
F. Raffi, V. Reliquet, V. Ferre, C. Arvieux, C. Hascoet, V. Bellein, et al.
The VIRGO study: Nevirapine, didanosine and stavudine combination therapy in antiretroviral-naive HIV-1-infected adults.
Antivir Ther, 5 (2000), pp. 267-272
[164.]
D. Podzamcer, E. Ferrer, E. Consiglio, J. Gatell, P. Pérez, K.P..
Final 12-month results from the combine study: A randomized, open, multicenter trial comparing combivir plus nelfinavir or nevirapine in naive patients.
[165.]
C.A. Sabin, M. Fisher, D. Churchill, A. Pozniak, P. Hay, P. Easterbrook, et al.
Long-term follow-up of antiretroviral-naive HIV-positive patients treated with nevirapine.
J Acquir Immune Defic Syndr, 26 (2001), pp. 462-465
[166.]
F. Raffi, V. Reliquet, D. Podzamczer, R.B. Pollard.
Efficacy of nevirapine-based HAART in HIV-1-infected, treatment-naive persons with high and low baseline viral loads.
HIV Clin Trials, 2 (2001), pp. 317-322
[167.]
J.R. Arribas, S. Staszewski, M. Nelson, C. Barros Aguado, R. Rubio Garcia, D. Podzamczer, et al.
3-year durability of response with an efavirenz (EFV)-containing regimen: 144 week follow-up of study 006.
[168.]
M. Dybul, T.W. Chun, D.J. Ward, K. Hertogs, B. Larder, C.H. Fox, et al.
Evaluation of lymph node virus burden in human immunodeficiency virus-infected patients receiving efavirenz-based protease inhibitor–sparing highly active antiretroviral therapy.
J Infect Dis, 181 (2000), pp. 1273-1279
[169.]
A. Stein, R. Luskin-Hawk, S. Pegram.
Efficacy of efavirenz in combination with stavudine (d4T) and didanosine (ddI) in antiretroviral therapy-naïve HIV-infected patients (Study 044).
[170.]
A.C. Friedl, B. Ledergerber, M. Flepp, B. Hirschel, A. Telenti, H. Furrer, et al.
Response to first protease inhibitor- and efavirenz-containing antiretroviral combination therapy. The Swiss HIV Cohort Study.
AIDS, 15 (2001), pp. 1793-1800
[171.]
G.M. Lucas, R.E. Chaisson, R.D. Moore.
Comparison of initial combination antiretroviral therapy with a single protease inhibitor, ritonavir and saquinavir, or efavirenz.
AIDS, 15 (2001), pp. 1679-1686
[172.]
A.C. Ghani, W.E. Henley, C.A. Donnelly, S. Mayer, R.M. Anderson.
Comparison of the effectiveness of non-nucleoside reverse transcriptase inhibitor-containing and protease inhibitor-containing regimens using observational databases.
AIDS, 15 (2001), pp. 1133-1142
[173.]
P. Keiser, N. Nassar, C. White, G. Koen, S. Moreno.
Comparison of efavirenz containing regimens to nevirapine containing regimens in anti-retroviral naive HIV infected patients: A cohort study.
[174.]
A. Cozzi Lepri, A.N. Phillips, A. d’Arminio Monforte, E. Raise, E. Rinaldi, V. Colangeli, et al.
Title Virological and immunological response to nevirapine or efavirenz in combination with two nucleoside analogues in the I.C.O.N.A. study.
[175.]
G.V. Matthews, C.A. Sabin, S. Mandalia, F. Lampe, A.N. Phillips, M.R. Nelson, et al.
Virological suppression at 6 months is related to choice of initial regimen in antiretroviral-naive patients: A cohort study.
AIDS, 16 (2002), pp. 53-61
[176.]
D.W. Haas, E. Arathoon, M.A. Thompson, Pedro R. de Jesus, J.E. Gallant, D.E. Uip, et al.
Comparative studies of two-times-daily versus three-times-daily indinavir in combination with zidovudine and lamivudine.
AIDS, 14 (2000), pp. 1973-1978
[177.]
Petersen A, Antunes F, Arasteh KN, Goebel FD, González-Lahoz J, Lazzarin A,et al. A comparison of the lonf-term antiviral efficacy of bid and tid dosing of nelfinavir in combination with stavudine (d4T) and lamivudine (3TC) beyond 48 weeks. 7th European Conference on Clinical Aspects and treatment of HIV-Infection; Lisboa, 1999. Resumen 205
[178.]
P. Bonfanti, L. Valsecchi, F. Parazzini, S. Carradori, L. Pusterla, P. Fortuna, et al.
Incidence of adverse reactions in HIV patients treated with protease inhibitors: A cohort study. Coordinamento Italiano Studio Allergia e Infezione da HIV (CISAI) Group.
J Acquir Immune Defic Syndr, 23 (2000), pp. 236-245
[179.]
O. Kirk, A. Mocroft, C. Pradier, J.N. Bruun, R. Hemmer, B. Clotet, et al.
Clinical outcome among HIV-infected patients starting saquinavir hard gel compared to ritonavir or indinavir.
AIDS, 15 (2001), pp. 999-1008
[180.]
J.W. Cohen Stuart, R. Schuurman, D.M. Burger, P.P. Koopmans, H.G. Sprenger, J.R. Juttmann, et al.
Randomized trial comparing saquinavir soft gelatin capsules versus indinavir as part of triple therapy (CHEESE study.
AIDS, 13 (1999), pp. F53-F58
[181.]
R.L. Murphy, R.M. Gulick, V. DeGruttola, R.T. D’Aquila, J.J. Eron, J.P. Sommadossi, et al.
Treatment with amprenavir alone or amprenavir with zidovudine and lamivudine in adults with human immunodeficiency virus infection. AIDS Clinical Trials Group 347 Study Team.
J Infect Dis, 179 (1999), pp. 808-816
[182.]
Montaner JSG, Saag MS, Barylski C, Siemon-Hryczyk P. FOCUS Study: Saquinavir QD regimen versus efavirenz QD regimen 24 week analysis in HIV infected patients. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-670
[183.]
Eron JJ, Bernstein B, King M, Manning L, Bertz R, Beall G,et al. Once-Daily vs Twice-Daily Kaletra (Lopinavir/Ritonavir) in Antiretroviral-Naïve HIV + Patients: 48-Week Follow-Up. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 409-W
[184.]
Ruane P, Mendonca J, Timerman A, Cernohous P, Bauer E, Bernstein B,et al. Kaletra vs. Nelfinavir in antiretroviral-naive subjects: Week 60 comparison in a phase III, blinded, randomized clinical trial. The 1st. IAS Conference on HIV Pathogenesis and Treatment; Buenos Aires, 2001. Resumen 6
[185.]
O. Kirk, T.L. Katzenstein, J. Gerstoft, L. Mathiesen, H. Nielsen, C. Pedersen, et al.
Combination therapy containing ritonavir plus saquinavir has superior short-term antiretroviral efficacy: A randomized trial.
Aids, 13 (1999), pp. F9-F16
[186.]
G.M. Lucas, R.E. Chaisson, R.D. Moore.
Highly active antiretroviral therapy in a large urban clinic: Risk factors for virologic failure and adverse drug reactions.
Ann Intern Med, 131 (1999), pp. 81-87
[187.]
B. Ledergerber, M. Egger, M. Opravil, A. Telenti, B. Hirschel, M. Battegay, et al.
Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: A prospective cohort study. Swiss HIV Cohort Study.
Lancet, 353 (1999), pp. 863-868
[188.]
J. Martín, I. Escobar, R. Rubio, G. Sabugal, J. Gascón, F. Pulido.
Study of the validity of a questionnaire to assess the adherence to therapy in patients infected by HIV.
HIV Clinical Trial, 2 (2001), pp. 31-77
[189.]
Montaner J, Hogg R, Yip B, Wood E, Harrigan R, O’Shaughnessy M. Further characterizing determinants of disease progression among HIV-1 infected patients iniating triple drug therapy. 1st IAS Conference on HIV Pathogenesis and Treatment; Buenos Aires, 2001. Resumen LB-010
[190.]
M.A. Chesney, J. Ickovics, F.M. Hecht, G. Sikipa, J. Rabkin.
Adherence: A necessity for successful HIV combination therapy.
AIDS, 13 (1999), pp. S271-S278
[191.]
R.H. Haubrich, S.J. Little, J.S. Currier, D.N. Forthal, C.A. Kemper, G.N. Beall, et al.
The value of patient-reported adherence to antiretroviral therapy in predicting virologic and immunologic response. California Collaborative Treatment Group.
AIDS, 13 (1999), pp. 1099-1107
[192.]
D.L. Paterson, S. Swindells, J. Mohr, M. Brester, E.N. Vergis, C. Squier, et al.
Adherence to protease inhibitor therapy and outcomes in patients with HIV infection.
Ann Intern Med, 133 (2000), pp. 21-30
[193.]
Casado JL, Knobel H, Sabido R, Ruiz I, Rodriguez MA. Initial adherence level predicts antiretroviral efficacy, clinical progression, and mortality: Results of a prospective, nation-based survey over 3,000 patients. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-1719
[194.]
Bartlett JA, DeMasi R, Quinn J, Moxham C, Rousseau F. Correlation between antiretroviral pill burden and durability of virologic response: A systematic overview. Int Conf AIDS; Durban, South Africa, 2000. Resumen ThPeB4998
[195.]
Campo M, Escobar I, Martin J, Torralba M, Costa S, Pulido F,et al. Profile of Patient with Non-Adherence to Highly Active Antiretroviral Therapy. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-1720
[196]
M. Tuset, J.M. Miró, C.J. Codina.
Interacciones medicamentosas de interés en la terapia del VIH.
Infección por VIH 1998 (1.a ed.), pp. 281-296
[197.]
M. Barry, F. Mulcahy, C. Merry, S. Gibbons, D. Back.
Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection.
Clin Pharmacokinet, 36 (1999), pp. 289-304
[198.]
D.V. Havlir, C. Tierney, G.H. Friedland, R.B. Pollard, L. Smeaton, J.P. Sommadossi, et al.
In vivo antagonism with zidovudine plus stavudine combination therapy.
J Infect Dis, 182 (2000), pp. 321-325
[199.]
P.G. Hoggard, S.D. Sales, S. Kewn, D. Sunderland, S.H. Khoo, C.A. Hart, et al.
Correlation between intracellular pharmacological activation of nucleoside analogues and HIV suppression in vitro.
Antivir Chem Chemother, 11 (2000), pp. 353-358
[200.]
D.S. Stein, K.H. Moore.
Phosphorylation of nucleoside analog antiretrovirals: A review for clinicians.
Pharmacotherapy, 21 (2001), pp. 11-34
[201.]
P.G. Hoggard, S.D. Sales, D. Phiboonbanakit, J. Lloyd, B.A. Maher, S.H. Khoo, et al.
Influence of prior exposure to zidovudine on stavudine phosphorylation in vivo and ex vivo.
Antimicrob Agents Chemother, 45 (2001), pp. 577-582
[202.]
J.D. Schuetz, M.C. Connelly, D. Sun, S.G. Paibir, P.M. Flynn, R.V. Srinivas, et al.
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.
Nat Med, 5 (1999), pp. 1048-1051
[203.]
W. Cavert, D.W. Notermans, K. Staskus, S.W. Wietgrefe, M. Zupancic, K. Gebhard, et al.
Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection.
Science, 276 (1997), pp. 960-964
[204.]
A. Erice, W. Li, H.H. Balfour, L.R. Boies, H. Melroe, K. Henry.
Analysis of HIV-1 reverse transcriptase and protease sequences in paired plasma and lymphoid tissue specimens from HIV-1 infected individuals.
AIDS, 15 (2001), pp. 831-836
[205.]
H.F. Gunthard, D.V. Havlir, S. Fiscus, Z.Q. Zhang, J. Eron, J. Mellors, et al.
Residual human immunodeficiency virus (HIV) Type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years.
J Infect Dis, 183 (2001), pp. 1318-1327
[206.]
M. Gisslen, L. Hagberg.
Antiretroviral treatment of central nervous system HIV-1 infection: A review.
HIV Med, 2 (2001), pp. 97-104
[207.]
Antinori A, Perno CF, Giancola ML, Forbici F, Ippolito G, Hoetelmans R,et al. Antiretroviral Distribution in Cerebrospinal Fluid and Viral Resistance in HIV-Infected Patients. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 438-W.
[208.]
J.W. Cohen Stuart, A.A. Wensing, C. Kovacs, M. Righart, D. de Jong, S. Kaye, et al.
Transient relapses (“blips”) of plasma HIV RNA levels during HAART are associated with drug resistance.
J Acquir Immune Defic Syndr, 28 (2001), pp. 105-113
[209.]
Havlir D, Bassett R, DeGruttola V, Hammer S, Gulick R, Mellors J. Are episodes of transient viremia (“Blips” in HIV RNA) predictive of virologic failure in heavily treatment-experienced patients?. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 93
[210.]
S.G. Deeks, J.D. Barbour, R.M. Grant, J.N. Martin.
Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremia.
AIDS, 16 (2002), pp. 201-207
[211.]
Euroguidelines.
Clinical and laboratory guidelines for the use of HIV-1 drug resistance testing as part of treatment management: Recommendations for the European setting.
AIDS, 15 (2001), pp. 309-320
[212.]
J.F. Delfraissy.
ew French guidelines for antiretroviral treatment.
HIV Med, 1 (2000), pp. 133-136
[213.]
M.A. Albrecht, R.J. Bosch, S.M. Hammer, S.H. Liou, H. Kessler, M.F. Para, et al.
elfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection.
Engl J Med, 345 (2001), pp. 398-407
[214.]
D.W. Haas, W.J. Fessel, R.A. Delapenha, H. Kessler, D. Seekins, M. Kaplan, et al.
Therapy with efavirenz plus indinavir in patients with extensive prior nucleoside reverse-transcriptase inhibitor experience: A randomized, double-blind, placebo-controlled trial.
J Infect Dis, 183 (2001), pp. 392-400
[215.]
L. Ross, K. Henry, D. Paar, P. Salvato, M. Shaefer, R. Fisher, et al.
Thymidine-analog and multi-nucleoside resistance mutations are observed in both zidovudine-naive and zidovudine-experienced subjects with viremia after treatment with stavudine-containing regimens.
J Hum Virol, 4 (2001), pp. 217-222
[216.]
V. Picard, E. Angelini, A. Maillard, E. Race, F. Clavel, G. Chene, et al.
Comparison of genotypic and phenotypic resistance patterns of human immunodeficiency virus type 1 isolates from patients treated with stavudine and didanosine or zidovudine and lamivudine.
J Infect Dis, 184 (2001), pp. 781-784
[217.]
N.S. Shulman, R.A. Machekano, R.W. Shafer, M.A. Winters, A.R. Zolopa, S.H. Liou, et al.
Genotypic correlates of a virologic response to stavudine after zidovudine monotherapy.
J Acquir Immune Defic Syndr, 27 (2001), pp. 377-380
[218.]
L. Sarmati, E. Nicastri, S.G. Parisi, G. D’Ettorre, P. Narciso, G. Mancino, et al.
Failure of stavudine-lamivudine combination therapy in antiretroviral-naive patients with AZT-like HIV-1 resistance mutations.
J Med Virol, 65 (2001), pp. 631-636
[219.]
Whitcomb JM, Paxinos E, Huang W, Maranta M, Limoli K, Chappey C,et al. The presence of nucleoside analogue mutations (NAMs) is highly correlated with reduced susceptibility to all NRTIs. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 569-T
[220.]
Harrigan PR, Mckenna P, Larder BA, Miller MD. Phenotypic analysis of tenofovir susceptibility among 5000 clinical HIV-1 isolates. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-1756
[221.]
Miller MD, Margot N, Naeger L, Coakley D, Cheng A. Anti-HIV responses and development of RT mutations in antiretroviral-experienced patients adding tenofovir DF therapy: Baseline and week 24 genotypic analysis of Study 907. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-1928
[222.]
Melby T, Tortell S, Thorborn D, Pearce G, Spreen W, Scott J,et al. Time to Appearance of NRTI-Associated Mutations and Response to Subsequent Therapy for Patients on Failing ABC/COM. 8th Conference on Retroviruses and Opportunistic Infections; Chicago, 2001. Resumen 448
[223.]
R.W. Shafer, D. Stevenson, B. Chan.
Human immunodeficiency virus reverse transcriptase and protease sequence database.
ucleic Acids Res, 27 (1999), pp. 348-352
[224.]
J.L. Casado, K. Hertogs, L. Ruiz, F. Dronda, A. Van Cauwenberge, A. Arno, et al.
Non-nucleoside reverse transcriptase inhibitor resistance among patients failing a nevirapine plus protease inhibitor-containing regimen.
AIDS, 14 (2000), pp. F1-F7
[225.]
C. Briones, V. Soriano, C. Dona, P. Barreiro, J. Gonzalez-Lahoz.
Can early failure with nevirapine be rescued with efavirenz?.
J Acquir Immune Defic Syndr, 24 (2000), pp. 76-78
[226.]
C. Delaugerre, R. Rohban, A. Simon, M. Mouroux, C. Tricot, R. Agher, et al.
Resistance profile and cross-resistance of HIV-1 among patients failing a non-nucleoside reverse transcriptase inhibitor-containing regimen.
J Med Virol, 65 (2001), pp. 445-448
[227.]
J. Durant, P. Clevenbergh, R. Garraffo, P. Halfon, S. Icard, P. Del Giudice, et al.
Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: Pharmacological data from the Viradapt Study.
AIDS, 14 (2000), pp. 1333-1339
[228.]
J.H. Condra, W.A. Schleif, O.M. Blahy, L.J. Gabryelski, D.J. Graham, J.C. Quintero, et al.
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.
Nature, 374 (1995), pp. 569-571
[229.]
M. Tisdale, R.E. Myers, B. Maschera, N.R. Parry, N.M. Oliver, E.D. Blair.
Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors.
Antimicrob Agents Chemother, 39 (1995), pp. 1704-1710
[230.]
H.B. Schock, V.M. Garsky, L.C. Kuo.
Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity.
J Biol Chem, 271 (1996), pp. 31957-31963
[231.]
Dronda F, Casado JL, Moreno S, Ruiz L, Antela A, Perez-Elias MJ,et al. Cross-resistance to nelfinavir can be predicted by previous antiretroviral exposure in the absence of D30N mutation. 7th Conference on Retroviruses and Opportunistic Infections; San Francisco, 2000. Resumen 729.
[232.]
C.A. Kemper, M.D. Witt, P.H. Keiser, M.P. Dube, D.N. Forthal, M. Leibowitz, et al.
Sequencing of protease inhibitor therapy: Insights from an analysis of HIV phenotypic resistance in patients failing protease inhibitors.
AIDS, 15 (2001), pp. 609-615
[233.]
A. Mocroft, A.N. Phillips, V. Miller, J. Gatell, J. van Lunzen, J.M. Parkin, et al.
The use of and response to second-line protease inhibitor regimens: Results from the EuroSIDA study.
AIDS, 15 (2001), pp. 201-209
[234.]
Mellors J, Vaida F, Bennett K, Hellmann NS, DeGruttola V, Hammer S. Efavirenz hypersusceptibility improves virologic response to multidrug salvage regimens in ACTG 398. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 45
[235.]
S.L. Walmsley, D.V. Kelly, A.L. Tseng, A. Humar, P.R. Harrigan.
Non-nucleoside reverse transcriptase inhibitor failure impairs HIV-RNA responses to efavirenz-containing salvage antiretroviral therapy.
AIDS, 15 (2001), pp. 1581-1584
[236.]
Munsiff A, Watson-Bitar M. How effective are various types of HAART after failure of an initial nefinavir-based regimen? XIII International AIDS Conference, Durban, Sudáfrica 2000. Resumen WePeB4176.
[237.]
Danner S, Brun S, Sylte J, Isaacson J, Lazzarin A, Girard PM,et al. Kaletra (lopinavir/ritonavir) and efavirenz: 72 week safety/efficacy evaluation and phenotypic/genotypic breakpoints in multiple PI experienced patients. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-1925.
[238.]
Isaacson J, Kempf D, Calvez V, Cohen-Codar I, Descamps D, Guillevic E,et al. Quantitative estimate of the effect of individual baseline mutations in HIV protease on the virologic response to lopinavir/ritonavir therapy in heavily antiretroviral-experienced patients. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 559-T
[239.]
Parkin NT, Chappey C, Petropoulos CJ. Relationship between lopinavir (LPV) susceptibility and HIV-1 protease genotype. 9th Conference on Retroviruses and Opportunistic Infections, 2002. Resumen 581-T.
[240.]
P. Tebas, A.K. Patick, E.M. Kane, M.K. Klebert, J.H. Simpson, A. Erice, et al.
Virologic responses to a ritonavir– saquinavir-containing regimen in patients who had previously failed nelfinavir.
AIDS, 13 (1999), pp. F23-F28
[241.]
Moreno A, Casado JL, Marte-Belda P, Sabido R, Garcia-Arata I, Martinez C,et al. Efficacy of the combination of ritonavir plus indinavir plus a nonnucleoside reverse transcriptase inhibitor in patients failing multiple antiretroviral regimens: Pharmacokinetic and resistance data (NIVELPROT study). XIII International AIDS Conference, Durban, Sudáfrica 2000. Resumen WePeB4159.
[242.]
Rice H, Zolopa A, Coram M, Murlidharan U, Shulman N, Vaamonde C, et al. Correlation of phenotypic resistance and virologic response to indinavir/ritonavir boosted regimens. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 558-T.
[243.]
Schmidt B. Cross-resistance to amprenavir in PI-treated patients. 7th Conference on Retroviruses and Opportunistic Infections; San Francisco, 2000. Resumen 726
[244.]
Brun S, Kempf D, Isaacson J, Molla A, Mo H, Benson C, et al. Patterns of protease inhibitor cross-resistance in viral isolates with reduced susceptibility to ABT-378. 8th Conference on Retroviruses and Opportunistic Infections; Chicago, 2001. Resumen 452.
[245.]
Swindells S, Cohen C, Berger D, Tashima K, Liao Q, Snidow J,et al. Virologic response to abacavir/efavirenz/ddI + hydroxyurea in subjects failing initial NRTI + PI therapy (NZTA4008 Study). 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-1918
[246.]
W.J. Fessel, S.E. Follansbee, T.P. Young.
Salvage therapy and formulation of highly active antiretroviral therapy.
J Acquir Immune Defic Syndr, 24 (2000), pp. 194-195
[247.]
S. Grabar, V. Le Moing, C. Goujard, C. Leport, M.D. Kazatchkine, D. Costagliola, et al.
Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy.
Ann Intern Med, 133 (2000), pp. 401-410
[248.]
Deeks S, Barbour J, Grant R, Martin J. Incidence and predictors of clinical progression among HIV-infected patients experiencing virologic failure of protease inhibitor-based regimens. 8th Conference on Retroviruses and Opportunistic Infections; Chicago, 2001. Resumen 428.
[249.]
S.G. Deeks, J.N. Martin.
Reassessing the goal of antiretroviral therapy in the heavily pre-treated HIV-infected patient.
AIDS, 15 (2001), pp. 117-119
[251.]
A. Mocroft, J.D. Lundgren, A.D. Phillips.
Response to salvage therapy in patients exposed to all three classes of antiretrovirals: The EuroSIDA study.
Antivir Ther, 5 (2000),
[252.]
Arrizabalaga J, Iribarren JA, Pinilla J, Rodriguez Arrondo FJ, Von Wichmann MA, Labarga P,et al. Prospective, multicenter study of ddI + hydroxyurea (HU) + efavirenz (EFV) + protease inhibitor (PI) salvage therapy. 1-year of follow-up. Correlation of viral outcome and genotypic mutations. XIII International AIDS Conference; Durban, Sudáfrica, 2000. Resumen WePeB4164
[253.]
R. Paredes, T. Puig, A. Arno, E. Negredo, M. Balague, A. Bonjoch, et al.
High-dose saquinavir plus ritonavir: Long-term efficacy in HIV-positive protease inhibitor-experienced patients and predictors of virologic response.
J Acquir Immune Defic Syndr, 22 (1999), pp. 132-138
[254.]
J.S. Montaner, P.R. Harrigan, N. Jahnke, J. Raboud, E. Castillo, R.S. Hogg, et al.
Multiple drug rescue therapy for HIV-infected individuals with prior virologic failure to multiple regimens.
AIDS, 15 (2001), pp. 61-69
[255.]
Katlama C, Dominguez S, Duvivier C, Delaugerre C, Peytavin G, Legrand M, et al. GIGHAART (ANRS 097): A prospective randomized trial comparing the efficacy of a salvage regimen administered with or without treatment interruption in patients with severe biological failure and extensive prior therapy. 8th European Conference on Clinical Aspects and Treatment of HIV-Infection; Atenas, 2001. Resumen 419.
[256.]
Ruiz L, Ribera E, Bonjoch A, Martinez-Picado J, Díaz M, Romeu J,et al. Virological and immunological benefit of a salvage therapy that includes kaletra plus fortovase preceded or not by antiretroviral therapy interruption in advanced HIV-infected patients (6-Month-Follow-up). 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 421-W
[257.]
Squires K, Pierone G, Berger D, Steinhart C, Bellos N, Becker SL,et al. Tenofovir DF: A 48-Week final analysis from a phase III randomized, double blind placebo controlled study in antiretroviral experienced patients. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 413-W
[258.]
Follansbee S, Reynes J, Nelson M, Clotet B, Lazzarin A, Adam A,et al. The Viread expanded access program: Safety and efficacy of Tenofovir disoproxil fumarate in antiretroviral treatment-experienced patients. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 415-W
[259.]
J.S. Montaner, C. Zala, B. Conway, J. Raboud, P. Patenaude, S. Rae, et al.
A pilot study of hydroxyurea among patients with advanced human immunodeficiency virus (HIV) disease receiving chronic didanosine therapy: Canadian HIV trials network protocol 080.
J Infect Dis, 175 (1997), pp. 801-806
[260.]
W.Y. Gao, A. Cara, R.C. Gallo, F. Lori.
Low levels of deoxynucleotides in peripheral blood lymphocytes: A strategy to inhibit human immunodeficiency virus type 1 replication.
Proc Natl Acad Sci USA, 90 (1993), pp. 8925-8928
[261.]
D.V. Havlir, P.B. Gilbert, K. Bennett, A.C. Collier, M.S. Hirsch, P. Tebas, et al.
Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression.
AIDS, 15 (2001), pp. 1379-1388
[262.]
J. Goodrich, N. Khardori.
Hydroxyurea toxicity in human immunodeficiency virus-positive patients.
Clin Infect Dis, 29 (1999), pp. 692-693
[263.]
S.B. Weissman, G.I. Sinclair, C.L. Green, W.H. Fissell, et al.
Hydroxyurea-induced hepatitis in human immunodeficiency virus-positive patients.
Clin Infect Dis, 29 (1999), pp. 223-224
[264.]
V. Miller, C. Sabin, K. Hertogs, S. Bloor, J. Martinez-Picado, R. D’Aquila, et al.
Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure.
AIDS, 14 (2000), pp. 2857-2867
[265.]
S.G. Deeks, T. Wrin, T. Liegler, R. Hoh, M. Hayden, J.D. Barbour, et al.
Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.
N Engl J Med, 344 (2001), pp. 472-480
[266.]
Ribera E, Aguirrebengoa K, Miralles C, Antela A, Rivero A, Arribas JR. Simplificación del tratamiento. Enferm Infecc Microbiol Clin 2002. [en prensa]
[267.]
P. Flandre, F. Raffi, D. Descamps, V. Calvez, G. Peytavin, V. Meiffredy, et al.
Final analysis of the Trilege induction-maintenance trial: Results at 18 months.
AIDS, 16 (2002), pp. 561-568
[268.]
M.H. Reijers, G.J. Weverling, S. Jurriaans, F.W. Wit, H.M. Weigel, R.W. Ten Kate, et al.
Maintenance therapy after quadruple induction therapy in HIV-1 infected individuals: Amsterdam Duration of Antiretroviral Medication (ADAM) study.
Lancet, 352 (1998), pp. 185-190
[269.]
D.A. Cooper, S. Emery.
Therapeutic strategies for HIV infection. Time to think hard.
N Engl J Med, 339 (1998), pp. 1319-1321
[270.]
Katlama C, Rachlis A, Staszewski S, Becker S, Manion DJ, Maa JF,et al. Better virologic suppression after substitution of protease inhibitors with efavirenz in patients with unquantifiable viral loads. 8th European Conference on Clinical Aspects and treatment of HIV-infection; Atenas, 2001. Resumen 06
[271.]
Becker S, Rachlis A, Gill J, Dejesus E, Pierone G, Kirkland L,et al. Successful substitution of protease inhibitors with efavirenz (EFV) in patients with undetectable viral loads—A prospective, randomized, multicenter, open-label study (DMP 049). 8th Conference on Retroviruses and Opportunistic Infections; Chicago, 2001. Resumen 20
[272.]
Katlama C, Stazewsky S, Clumeck N, Arasteh K, Dellamonica P, Molina JM,et al. Successful substitution of protease inhibitors with Sustiva (efavirenz) in patients with undetectable plasma HIV-1 RNA: Results of a prospective, randomized, multicenter, open-label study (DMP 006-027). XIII International AIDS Conference; Durban, Suráfrica, 2000. Resumen LbPeB7044
[273.]
E. Negredo, L. Cruz, R. Paredes, L. Ruiz, C.R. Fumaz, A. Bonjoch, et al.
Virological, immunological, and clinical impact of switching from protease inhibitors to nevirapine or to efavirenz in patients with human immunodeficiency virus infection and long-lasting viral suppression.
Clin Infect Dis, 34 (2002), pp. 504-510
[274.]
Maggiolo F, Migliorino M, Maserati R, Gregis G, Quinzan G, Ripamonti D,et al. Simplified therapeutic strategies in PI-experienced patients successfully treated with HAART. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-1916
[275.]
P. Barreiro, V. Soriano, F. Blanco, C. Casimiro, J.J. de la Cruz, J. Gonzalez-Lahoz.
Risks and benefits of replacing protease inhibitors by nevirapine in HIV-infected subjects under long-term successful triple combination therapy.
AIDS, 14 (2000), pp. 807-812
[276.]
L. Ruiz, E. Negredo, P. Domingo, R. Paredes, E. Francia, M. Balague, et al.
Antiretroviral treatment simplification with nevirapine in protease inhibitor-experienced patients with HIV-associated lipodystrophy: 1-year prospective follow-up of a multicenter, randomized, controlled study.
J Acquir Immune Defic Syndr, 27 (2001), pp. 229-236
[277.]
N. Clumeck, F. Goebel, W. Rozenbaum, J. Gerstoft, S. Staszewski, J. Montaner, et al.
Simplification with abacavir-based triple nucleoside therapy versus continued protease inhibitor-based highly active antiretroviral therapy in HIV-1-infected patients with undetectable plasma HIV-1 RNA.
AIDS, 15 (2001), pp. 1517-1526
[278.]
Katlama C, Fenske S, Gazzard B, Lazzarin A, Beauvais L. Switch to Trizivir versus continued HAART provides equivalent HIV-1 RNA suppression at 48 weeks (TRIZAL-AZL30002). 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-671
[279.]
Opravil M, Yerly S, Lazzarin A, Furrer HJ, Chave JP, Vernazza P,et al. Protease inhibitor class-sparing maintenance therapy with abacavir (ABC) + lamivudine (3TC) + zidovudine (ZDV) in patients with long-term suppression of HIV-1 RNA. 7th Conference on Retroviruses and Opportunistic Infections, San Francisco, 2000. Resumen 457
[280.]
Pulvirenti J, Goodwin D, Slater L. Simplification of protease inhibitor- containing HAART regimens with abacavir maintains viral suppression and favourable adherence in HIV-1 infected adults (COLA30305). 39th Annual Meeting of the Infectious Disease Society of America; San Francisco, 2001. Resumen 689
[281.]
Martinez E, Podzamczer D, Ribera E, Domingo P, Knobel H, Dalmau D,et al. Switching protease inhibitors to nevirapine (NEV), efavirenz (EFA) or abacavir (ABA): A randomized, multicenter, open-label, simplification trial. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen LB17
[282.]
Fisac C, Fumero E, Crespo M, Rosón B, Virgili N, Ribera E,et al. A randomized trial of metabolic and body composition changes in patients switching from PI-containing regimens to abacavir (ABC), efavirenz (EFV) or nevirapine (NVP). 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 699-T
[283.]
M.A. Chesney.
Factors affecting adherence to antiretroviral therapy.
Clin Infect Dis, 30 (2000), pp. S171-S176
[284.]
Carmona A, Knobel H, Guelar A, Grau S, Mateu de Antonio J, Lopez-Colomes JL. Factors influencing survival in HIV infected patients treated with HAART. XIII nternational AIDS Conference; Durban, South Africa, 2000. Resumen TuOrB417
[285.]
Hogg R, Yip B, Chan K, O’Shaughnessy M, Montaner J. Non-adherence to triple combination therapy is predictive of AIDS progression and death in HIV-positive men and women. XIII International AIDS Conference; Durban, South Africa, 2000. Resumen TuOrB419
[286.]
H. Knobel, A. Carmona, S. Grau, J. Pedro-Botet, A. Diez.
Adherence and effectiveness of highly active antiretroviral therapy.
Arch Intern Med, 158 (1998), pp. 1953
[287.]
R. Rodriguez-Rosado, I. Jimenez-Nacher, V. Soriano, P. Anton, J. Gonzalez-Lahoz.
Virological failure and adherence to antiretroviral therapy in HIV-infected patients.
AIDS, 12 (1998), pp. 1112-1113
[288.]
Knobel H, Miró JM, Rubio R, Gatell JM, Del Campo A. Compliance with antiretroviral treatment: The physician’s perspective. 7th European Conference on Clinical Aspects and treatment of HIV- Infection; Lisboa, Portugal, 1999. Resumen 511
[289.]
Knobel H, Rubio R, Miró JM, Gatell JM, Del Campo A. Adherence to antiretroviral therapy: The patient’s perspective. 7th European Conference on Clinical Aspects and treatment of HIV- Infection; Lisboa, Portugal, 1999. Resumen 857
[290.]
V.E. Stone.
Strategies for optimizing adherence to highly active antiretroviral therapy: Lessons from research and clinical practice.
Clin Infect Dis, 33 (2001), pp. 865-872
[291.]
Rubio R, Miró JM, Knobel H, Gatell JM, Del Campo A. Prospective study on adherence to antiretroviral treatment: Future perspectives in Spain. 7th European Conference on Clinical Aspects and treatment of HIV-Infection; Lisboa, Portugal 1999. Resumen 516
[292.]
Collier AC, Ribaudo H, Feinberg J, Mukherjee L, Fischl M, Chesney M. Randomized study of telephone calls to improve adherence to antiretroviral therapy. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 540-T
[293.]
H. Knobel, J. Alonso, J.L. Casado, J. Collazos, J. Gonzalez, I. Ruiz, et al.
Validation of a simplified medication adherence questionnaire in a large cohort of HIV-infected patients: The GEEMA Study.
AIDS, 16 (2002), pp. 605-613
[294.]
Casado JL, Knobel H, Collazos J, Kindelán JM, Gordillo V, González J. Influencia de factores sociales en la adherencia al tratamiento antirretroviral. X Congreso de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica; Sevilla, 2002. Resumen 543
[295.]
Casado JL, Knobel H, Sabido R, Ruiz I, Rodríguez MA, Traseira S. Importance of the physician-patient communication in explaining lack of adherence to HAART. 8th European Conference on Clinical Aspects and Treatment of HIV Infection; Atenas, 2001. Resumen 83
[296.]
Casado JL, Knobel H, Sabido R, Ruiz I, Rodríguez MA, Carmona A,et al. Quantification of the differences in adherence between the clinical setting and clinical trials. 8th European Conference on Clinical Aspects and Treatment of HIV Infection; Atenas, 2001. Resumen 84
[297.]
B. Max, R. Sherer.
Management of the adverse effects of antiretroviral therapy and medication adherence.
Clin Infect Dis, 30 (2000), pp. 96-116
[298.]
D.D. Richman, M.A. Fischl, M.H. Grieco, M.S. Gottlieb, P.A. Volberding, O.L. Laskin, et al.
The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
N Engl J Med, 317 (1987), pp. 192-197
[299.]
M.C. Dalakas, I. Illa, G.H. Pezeshkpour, J.P. Laukaitis, B. Cohen, J.L. Griffin.
Mitochondrial myopathy caused by long-term zidovudine therapy.
N Engl J Med, 322 (1990), pp. 1098-1105
[300.]
D.M. Simpson, M. Tagliati.
Nucleoside analogue-associated peripheral neuropathy in human immunodeficiency virus infection.
J Acquir Immune Defic Syndr Hum Retrovirol, 9 (1995), pp. 153-161
[301.]
J. Blanch, E. Martinez, A. Rousaud, J.L. Blanco, M.A. Garcia-Viejo, J.M. Peri, et al.
Preliminary data of a prospective study on neuropsychiatric side effects after initiation of efavirenz.
J Acquir Immune Defic Syndr, 27 (2001), pp. 336-343
[302.]
H. Knobel, J.M. Miro, P. Domingo, A. Rivero, M. Marquez, L. Force, et al.
Failure of a short-term prednisone regimen to prevent nevirapine-associated rash: A double-blind placebo-controlled trial: The GESIDA 09/99 Study.
J Acquir Immune Defic Syndr, 28 (2001), pp. 14-18
[303.]
S. Mallal, D. Nolan, C. Witt, G. Masel, A.M. Martin, C. Moore, et al.
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir.
Lancet, 359 (2002), pp. 727-732
[304.]
M. den Brinker, F.W. Wit, P.M. Wertheim-van Dillen, S. Jurriaans, J. Weel, R. van Leeuwen, et al.
Hepatitis B and C virus co-infection and the risk for hepatotoxicity of highly active antiretroviral therapy in HIV-1 infection.
AIDS, 14 (2000), pp. 2895-2902
[305.]
E. Martinez, J.L. Blanco, J.A. Arnaiz, J.B. Perez-Cuevas, A. Mocroft, A. Cruceta, et al.
Hepatotoxicity in HIV-1-infected patients receiving nevirapine-containing antiretroviral therapy.
AIDS, 15 (2001), pp. 1261-1268
[306.]
M.S. Sulkowski, D.L. Thomas, S.H. Mehta, R.E. Chaisson, R.D. Moore.
Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: Role of hepatitis C and B infections.
Hepatology, 35 (2002), pp. 182-189
[307.]
E. Martinez, M. Leguizamon, J. Mallolas, J.M. Miro, J.M. Gatell.
Influence of environmental temperature on incidence of indinavir-related nephrolithiasis.
Clin Infect Dis, 29 (1999), pp. 422-425
[308.]
V. Falco, D. Rodriguez, E. Ribera, E. Martinez, J.M. Miro, P. Domingo, et al.
Severe nucleoside-associated lactic acidosis in human immunodeficiency virus-infected patients: Report of 12 cases and review of the literature.
Clin Infect Dis, 34 (2002), pp. 838-846
[309.]
G. Moyle, C. Baldwin, M. Phillpot.
Managing metabolic disturbances and lipodystrophy: Diet, exercise, and smoking advice.
The AIDS Reader, 11 (2001), pp. 589-592
[310.]
E. Martinez, M.A. Garcia-Viejo, L. Blanch, J.M. Gatell.
Lipodystrophy syndrome in patients with HIV infection: Quality of life issues.
Drug Saf, 24 (2001), pp. 157-166
[311.]
T. Saint-Marc, M. Partisani, I. Poizot-Martin, F. Bruno, O. Rouviere, J.M. Lang, et al.
A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy.
AIDS, 13 (1999), pp. 1659-1667
[312.]
E. Martinez, A. Mocroft, M.A. Garcia-Viejo, J.B. Perez Cuevas, J.L. Blanco, J. Mallolas, et al.
Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: A prospective cohort study.
Lancet, 357 (2001), pp. 592-598
[313.]
Hetherington S, Steel H, Naderer O, Cutrell A, Powell W, Sykes R. Hypersensitivity reactions during therapy with abacavir: Analysis of 636 cases for clinical presentation and risk factors. 7th Conference on Retroviruses and Opportunistic Infections; San Francisco, 2000. Resumen 60
[314.]
M.P. Dube, D. Sprecher, W.K. Henry, J.A. Aberg, F.J. Torriani, H.N. Hodis, et al.
Preliminary guidelines for the evaluation and management of dyslipidemia in adults infected with human immunodeficiency virus and receiving antiretroviral therapy: Recommendations of the Adult AIDS Clinical Trial Group Cardiovascular Disease Focus Group.
Clin Infect Dis, 31 (2000), pp. 1216-1224
[315.]
Adult Treatment Panel III. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults.
JAMA, 285 (2001), pp. 2486-2497
[316.]
M.P. Dube.
Disorders of glucose metabolism in patients infected with human immunodeficiency virus.
Clin Infect Dis, 31 (2000), pp. 1467-1475
[317.]
Mary-Krause M, Cotte L, Partisan M, Simon A, Costagliola D. Impact of treatment with protease inhibitor (PI) on myocardial infarction (MI) occurrence in HIV-infected men. 8th Conference on Retroviruses and Opportunistic Infections; Chicago, 2001. Resumen 657
[318.]
E. Martinez, I. Conget, L. Lozano, R. Casamitjana, J.M. Gatell.
Reversion of metabolic abnormalities after switching from HIV-1 protease inhibitors to nevirapine.
AIDS, 13 (1999), pp. 805-810
[319.]
E. Martinez, M.A. Garcia-Viejo, J.L. Blanco, L. Bianchi, E. Buira, I. Conget, et al.
Impact of switching from human immunodeficiency virus type 1 protease inhibitors to efavirenz in successfully treated adults with lipodystrophy.
Clin Infect Dis, 31 (2000), pp. 1266-1273
[320.]
Cohen C, Shen Y, Rode R, Cameron DW, Mellors J, Farthing C,et al. Effect of nucleoside (NRTI) intensification on prevalence of morphologic abnormalities (MoAs) at year 5 of ritonavir (RTV) plus saquinavir (SQV) therapy in an HIV-infected cohort. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 683-T
[321.]
Carr A, Smith D, Workman C, Hoy J, Doong N, Amin J,et al. Switching Stavudine or Zidovudine to Abacavir for HIV Lipoatrophy: A Randomised, Controlled, Open-Label, Multicentre, 24-Week Study. 9th Conference on Retroviruses and Opportunistic Infections, Seattle, 2002. Resumen 32
[322.]
John M, James I, McKinnon E, Nolan D, Herrmann S, Cain A,et al. A randomised, controlled, open-label study of revision of antiretroviral regimens containing stavudine (d4T) and/or a protease inhibitor (PI) to zidovudine (ZDV)/lamivudine (3TC)/abacavir (ABC) to prevent or reverse lipoatrophy: 48-week data. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 700-T
[323.]
McComsey G, Lonergan T, Fisher R, Sension M, Hoppel C, Williams V,et al. Improvements in lipoatrophy (LA) are observed after 24 weeks when stavudine (d4T) is replaced by either abacavir (ABC) or zidovudine (ZDV). 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 701-T
[324.]
C. Hadigan, C. Corcoran, N. Basgoz, B. Davis, P. Sax, S. Grinspoon.
Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled trial.
JAMA, 284 (2000), pp. 472-477
[325.]
R. Walli, G.M. Michl, D. Muhlbayer, L. Brinkmann, F.D. Goebel.
Effects of troglitazone on insulin sensitivity in HIV-infected patients with protease inhibitor-associated diabetes mellitus.
Res Exp Med (Berl), 199 (2000), pp. 253-262
[326.]
Sutinen J, Hakkinen AM, Westerbacka J, Vehkavaara S, Halavaara J, Jarvinen A,et al. Rosiglitazone in the treatment of HAART associated lipodystrophy (HAL): A randomized, double-blind, placebo-controlled study. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen LB13
[327.]
S. Ponce-de-Leon, M. Iglesias, J. Ceballos, L. Ostrosky-Zeichner.
Liposuction for protease-inhibitor-associated lipodystrophy.
Lancet, 353 (1999), pp. 1244
[328.]
Martínez E, Fernández Miranda C, Conget I, Moreno S, Santamaría JM, Boix V; ,et al. Actitud ante las alteraciones metabólicas y de distribución de la grasa corporal en pacientes infectados por el virus de la inmunodeficiencia humana que reciben tratamiento antirretroviral. Disponible en: www.gesidaseimc.com, 2002
[329.]
P. Tebas, W.G. Powderly, S. Claxton, D. Marin, W. Tantisiriwat, S.L. Teitelbaum, et al.
Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy.
AIDS, 14 (2000), pp. F63-F67
[330.]
A.N. Scribner, P.V. Troia-Cancio, B.A. Cox, D. Marcantonio, F. Hamid, P. Keiser, et al.
Osteonecrosis in HIV: A case-control study.
J Acquir Immune Defic Syndr, 25 (2000), pp. 19-25
[331.]
M. Tuset, J.M. Miró, C. Codina, J. Ribas.
Guía de interacciones farmacológicas en VIH. En CD-ROM (2.aed.
[332.]
S.C. Piscitelli, K.A. Rodvold.
Drug interactions in infectious diseases.
[333.]
A. Dasgupta, P.C. Okhuysen.
Pharmacokinetic and other drug interactions in patients with AIDS.
Ther Drug Monit, 23 (2001), pp. 591-605
[334.]
S.C. Piscitelli, K.D. Gallicano.
Interactions among drugs for HIV and opportunistic infections.
N Engl J Med, 344 (2001), pp. 984-996
[335.]
W.J. Burman, B.E. Jones.
Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy.
Am J Respir Crit Care Med, 164 (2001), pp. 7-12
[336.]
Centers for Disease Control and Prevention. Updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors.
MMWR Morb Mortal Wkly Rep, 49 (2000), pp. 185-189
[337.]
E. Ribera, L. Pou, R.M. Lopez, M. Crespo, V. Falco, I. Ocana, et al.
Pharmacokinetic interaction between nevirapine and rifampicin in HIV-infected patients with tuberculosis.
J Acquir Immune Defic Syndr, 28 (2001), pp. 450-453
[338.]
M.N. Gourevitch, G.H. Friedland.
Interactions between methadone and medications used to treat HIV infection: A review.
Mt Sinai J Med, 67 (2000), pp. 429-436
[339.]
S. Clarke, F. Mulcahy, C. Bergin, H. Reynolds, N. Boyle, M. Barry, et al.
Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor lopinavir-ritonavir.
Clin Infect Dis, 34 (2002), pp. 1143-1145
[340.]
S.M. Clarke, F.M. Mulcahy, J. Tjia, H.E. Reynolds, S.E. Gibbons, M.G. Barry, et al.
Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users.
Clin Infect Dis, 33 (2001), pp. 1595-1597
[341.]
S.M. Clarke, F.M. Mulcahy, J. Tjia, H.E. Reynolds, S.E. Gibbons, M.G. Barry, et al.
The pharmacokinetics of methadone in HIV-positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz.
Br J Clin Pharmacol, 51 (2001), pp. 213-217
[342.]
C.J. Fichtenbaum, J.G. Gerber, S.L. Rosenkranz, Y. Segal, J.A. Aberg, T. Blaschke, et al.
Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047.
AIDS, 16 (2002), pp. 569-577
[343.]
I.H. Stockley.
Drug Interactions. 5.aEd.
[344.]
D. Jayasekara, F.T. Aweeka, R. Rodriguez, R.C. Kalayjian, M.H. Humphreys, J.G. Gambertoglio.
Antiviral therapy for HIV patients with renal insufficiency.
J Acquir Immune Defic Syndr, 21 (1999), pp. 384-395
[345.]
A.M. Taburet, S. Naveau, G. Zorza, J.N. Colin, J.F. Delfraissy, J.C. Chaput, et al.
Pharmacokinetics of zidovudine in patients with liver cirrhosis.
Clin Pharmacol Ther, 47 (1990), pp. 731-739
[346.]
J.M. Guardiola, M.A. Mangues, P. Domingo, E. Martinez, J.L. Barrio.
Indinavir pharmacokinetics in haemodialysis-dependent end-stage renal failure.
AIDS, 12 (1998), pp. 1395
[347.]
P.G. Hoggard, S.D. Sales, S. Kewn, D. Sunderland, S.H. Khoo, C.A. Hart, et al.
Correlation between intracellular pharmacological activation of nucleoside analogues and HIV suppression in vitro.
Antivir Chem Chemother, 11 (2000), pp. 353-358
[348.]
M.S. Sulkowski, D.L. Thomas, R.E. Chaisson, R.D. Moore.
Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.
JAMA, 283 (2000), pp. 74-80
[349.]
K.H. Moore, R.H. Raasch, K.L. Brouwer, K. Opheim, S.H. Cheeseman, E. Eyster, et al.
Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease (AIDS Clinical Trials Group protocol 062).
Antimicrob Agents Chemother, 39 (1995), pp. 2732-2737
[350.]
M.A. Johnson, J. Horak, P. Breuel.
The pharmacokinetics of lamivudine in patients with impaired hepatic function.
Eur J Clin Pharmacol, 54 (1998), pp. 363-366
[351.]
H.J. Schaad, B.G. Petty, D.M. Grasela, B. Christofalo, R. Raymond, M. Stewart.
Pharmacokinetics and safety of a single dose of stavudine (d4T) in patients with severe hepatic impairment.
Antimicrob Agents Chemother, 41 (1997), pp. 2793-2796
[352.]
Fiske W, Benedek I, Brennan J, Davidson A, Gillette S, Joseph J,et al. Pharmacokinetics of efavirenz in subjects with chronic liver disease. 6th Conference on Retroviruses and Opportunistic Infections; Chicago, 1999. Resumen 367
[353.]
N. Tachikawa, S. Yoshizawa, Y. Kikuchi, A. Yasuoka, S. Oka.
Saquinavir therapy in patients with the advanced HIV infection and liver cirrhosis.
Jpn J Infect Dis, 52 (1999), pp. 177-178
[354.]
Khaliq Y, Gallicano K, Seguin I, Fyke K, Carignan G, Badley A,et al. Therapeutic Drug Monitoring of Nelfinavir in HIV Patients with Liver Disease. 6th Conference on Retroviruses and Opportunistic Infections; Chicago, 1999. Resumen 369
[355.]
Y. Khaliq, K. Gallicano, I. Seguin, K. Fyke, G. Carignan, D. Bulman, et al.
Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease.
Br J Clin Pharmacol, 50 (2000), pp. 108-115
[356.]
L. Veronese, J. Rautaureau, B.M. Sadler, C. Gillotin, J.P. Petite, B. Pillegand, et al.
Single-dose pharmacokinetics of amprenavir, a human immunodeficiency virus type 1 protease inhibitor, in subjects with normal or impaired hepatic function.
Antimicrob Agents Chemother, 44 (2000), pp. 821-826
[357.]
M.P. Manns, J.G. McHutchison, S.C. Gordon, V.K. Rustgi, M. Shiffman, R. Reindollar, et al.
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial.
Lancet, 358 (2001), pp. 958-965
[358.]
Pérez-Olmeda M, Asensi V, Romero M, Colmenero M, Sánchez-Montero F, Ochoa A,et al. Treatment of chronic hepatitis C: SHIRT (Spanish HIV Interferon Ribavirin Trial). 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 653-M
[359.]
Pérez-Olmeda M, Núñez M, Romero M, González J, Castro A, Arribas JR,et al. Pegylated Interferon plus Ribavirin as Therapy for Chronic Hepatitis C in HIV-Infected Patients. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002. Resumen 652-M
[360.]
J. Balzarini, P. Herdewijn, E. De Clercq.
Potentiating effect of ribavirin on the anti-retrovirus activity of 3’-azido-2,6-diaminopurine-2’,3’-dideoxyriboside in vitro and in vivo.
Antiviral Res, 11 (1989), pp. 161-171
[361.]
M. Baba, R. Pauwels, J. Balzarini, P. Herdewijn, E. De Clercq, J. Desmyter.
Ribavirin antagonizes inhibitory effects of pyrimidine 2’,3’-dideoxynucleosides but enhances inhibitory effects of purine 2’,3’-dideoxynucleosides on replication of human immunodeficiency virus in vitro.
Antimicrob Agents Chemother, 31 (1987), pp. 1613-1617
[362.]
A.J. Japour, J.J. Lertora, P.M. Meehan, A. Erice, J.D. Connor, B.P. Griffith, et al.
A phase-I study of the safety, pharmacokinetics, and antiviral activity of combination didanosine and ribavirin in patients with HIV-1 disease. AIDS Clinical Trials Group 231 Protocol Team.
J Acquir Immune Defic Syndr Hum Retrovirol, 13 (1996), pp. 235-246
[364.]
J.A. Carton, J.A. Maradona, V. Asensi, M. Rodriguez, A. Martinez.
Lamivudine for chronic hepatitis B and HIV co-infection.
AIDS, 13 (1999), pp. 1002-1003
[365.]
M. Bessesen, D. Ives, L. Condreay, S. Lawrence, K.E. Sherman.
Chronic active hepatitis B exacerbations in human immunodeficiency virus-infected patients following development of resistance to or withdrawal of lamivudine.
Clin Infect Dis, 28 (1999), pp. 1032-1035
[366.]
The Working Group on Mother-To-Child Transmission of HIV. Rates of mother-to-child transmission of HIV-1 in Africa, America, and Europe: Results from 13 perinatal studies.
J Acquir Immune Defic Syndr Hum Retrovirol, 8 (1995), pp. 506-510
[367.]
M.L. Newell.
Mechanisms and timing of mother-to-child transmission of HIV-1.
AIDS, 12 (1998), pp. 831-837
[368.]
J.P. Ioannidis, E.J. Abrams, A. Ammann, M. Bulterys, J.J. Goedert, L. Gray, et al.
Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads < 1000 copies/ml.
J Infect Dis, 183 (2001), pp. 539-545
[369.]
M.F. Rogers, N. Shaffer.
Reducing the risk of maternal-infant transmission of HIV by attacking the virus.
N Engl J Med, 341 (1999), pp. 441-443
[370.]
L.M. Mofenson, J.A. McIntyre.
Advances and research directions in the prevention of mother-to-child HIV-1 transmission.
Lancet, 355 (2000), pp. 2237-2244
[371.]
E.M. Connor, R.S. Sperling, R. Gelber, P. Kiselev, G. Scott, M.J. O’Sullivan, et al.
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
N Engl J Med, 331 (1994), pp. 1173-1180
[372.]
R.S. Sperling, D.E. Shapiro, R.W. Coombs, J.A. Todd, S.A. Herman, G.D. McSherry, et al.
Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
N Engl J Med, 335 (1996), pp. 1621-1629
[373.]
L.A. Guay, P. Musoke, T. Fleming, D. Bagenda, M. Allen, C. Nakabiito, et al.
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial.
Lancet, 354 (1999), pp. 795-802
[374.]
Jackson JB, Mracna M, Guay L, Dileanis JA, Musoke P, Mmiro F,et al. Selection of nevirapine (NVP) reistance mutations in Ugandan women and infants receiving NVP prophylaxis to prevent HIV-1 vertical transmission (HIVNET 012). XIII International AIDS Conference; Durban, Suráfrica, 2000. Resumen LbOr13
[375.]
Dorenbaum A for The PPACTG 316 Study Team. Report of results of PPACTG 316: An International phase III trial of standars antiretroviral (ARV) prophylaxis plus nevirapine (NVP) for prevention of perinatal HIV transmission. 8th Conference on Retroviruses and Opportunistic Infections; Chicago, 2001. Resumen LB7
[376.]
Frenkel LM. Pediatric Potpourri. 7th Conference on Retrovirus and Opportunistic Infections; San Francisco, Summary 4-February, 2000. Disponible en; www.medscape.com
[377.]
Blattner W, Cooper E, Charurat M, Thompson B, Hanson C, Mofenson L,et al. Effectiveness of potent anti-retroviral therapies on reducing perinatal transmission of HIV-1. XIII International AIDS Conference; Durban, Suráfrica, 2000. Resumen LbOr4
[378.]
Public Health Service Task Force. Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States. February 4, 2002. Disponible en; http://www.hivatis.org.
[379.]
S. Blanche, M. Tardieu, P. Rustin, A. Slama, B. Barret, G. Firtion, et al.
Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues.
Lancet, 354 (1999), pp. 1084-1089
[380.]
Hanson C, Frederick M, McIntosh K. Evaluation of living uninfected children for mitochondrial defects: Women and infants transmission study, 7th Conference on Retroviruses and Opportunistic Infections; San Francisco, 2000. Resumen 665
[381.]
Birkhead G, Wadw N, Storfer-Isser A, Gallagher B, Singh T, Bornschlegel K. Review of deaths among a cohort of New York State (NYS) infants exposed in the perinatal period to HIV and antiretroviral drugs. 7th Conference on Retroviruses and Opportunistic Infections; San Francisco, 2000. Resumen 692
[382.]
McIntosh K. Mitochondrial Toxicity of Perinatally Administered Zidovudine. 7th Conference on Retroviruses and Opportunistic Infections; San Francisco, 2000. Resumen S14
[383.]
Garcia PM, Beckerman K, Watts DH, Fox HE, Rodríguez E, Tilson H,et al. Assesing the teratogenic potential of antiretroviral drugs: Data from the Antiretroviral Pregnancy Registry. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen I-1325
[384.]
Bristol-Myers Squibb Company. Healthcare Provider Important Drug Warning Letter, January 5, 2001
[385.]
Marcus K, Truffa M, Boxwell D, Toerner J. Recently identified adverse events secondary to NRTI therapy in HIV-infected individuals: Cases from the FDA’s adverse event reporting system (AERS). 9th Conference on Retroviruses and Opportunistic Infections, 2002. Resumen LB14
[386.]
Foster CJ. Lactic acidosis and pancreatitis in the third trimester of pregnancy as a result of antiretroviral medication. 7th Annual Conference of The British HIV Association, 2001. Resumen 023
[387.]
The International Perinatal HIV Group. The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1–a meta-analysis of 15 prospective cohort studies.
N Engl J Med, 340 (1999), pp. 977-987
[388.]
The European Mode of Delivery Collaboration. Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: A randomised clinical trial.
Lancet, 353 (1999), pp. 1035-1039
[389.]
Shapiro D, Tuomala R, Samelson R, Burchett S, Ciupak G, McNamara J,et al. Mother-to-child HIV transmission rates according to antiretroviral therapy, mode of delivery, and viral load (PACTG 367). 9th Conference on Retroviruses and Opportunistic Infections, 2002. Resumen 114
[390.]
J.M. Peña.
Transmisión vertical del VIH-1.¿Hasta dónde se puede reducir?.
Med Clin (Barc, 114 (2000), pp. 297-298
[391.]
D.M. Bell.
Occupational risk of human immunodeficiency virus infection in healthcare workers: An overview.
Am J Med, 102 (1997), pp. 9-15
[392.]
G. Ippolito, V. Puro, G. De Carli.
The risk of occupational human immunodeficiency virus infection in health care workers. Italian Multicenter Study. The Italian Study Group on Occupational Risk of HIV infection.
Arch Intern Med, 153 (1993), pp. 1451-1458
[393.]
D.M. Cardo, D.H. Culver, C.A. Ciesielski, P.U. Srivastava, R. Marcus, D. Abiteboul, et al.
A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group.
N Engl J Med, 337 (1997), pp. 1485-1490
[394.]
P.M. Grob, Y. Cao, E. Muchmore, D.D. Ho, S. Norris, J.W. Pav, et al.
Prophylaxis against HIV-1 infection in chimpanzees by nevirapine, a nonnucleoside inhibitor of reverse transcriptase.
Nat Med, 3 (1997), pp. 665-670
[395.]
Expert Advisory Group on AIDS. Guidelines on post-exposure prophylaxis for health care workers occupationally exposed to HIV.
[396.]
J.L. Gerberding.
Prophylaxis for occupational exposure to HIV.
Ann Intern Med, 125 (1996), pp. 497-501
[397.]
Centers for Disease Control and Prevention. Update: Provisional Public Health Service recommendations for chemoprophylaxis after occupational exposure to HIV.
MMWR Morb Mortal Wkly Rep, 45 (1996), pp. 468-480
[398.]
Centers for Disease Control and Prevention. Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis.
MMWR Recomm Rep, 50 (2001), pp. 1-52
[399.]
Centers for Disease Control and Prevention. Serious adverse events attributed to nevirapine regimens for postexposure prophylaxis after HIV exposures–worldwide, 1997-2000.
MMWR Morb Mortal Wkly Rep, 49 (2001), pp. 1153-1156
[400.]
P.C. Tack, J.W. Bremer, A.A. Harris, A.L. Landay, H.A. Kessler, D.R. Kuritzkes.
Genotypic analysis of HIV-1 isolates to identify antiretroviral resistance mutations from source patients involved in health care worker occupational exposures.
JAMA, 281 (1999), pp. 1085-1086
[401.]
Prevot MH, Descamps D, Migueres B, Troude C, Tarantola A, Collin G,et al. Antiretroviral Resistance Patterns in HIV-1 Infected Source Patients During Occupational Exposure to Blood in French Hospitals. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy; Toronto, 2000. Resumen 1246
[402.]
V. Puro.
Post-exposure prophylaxis for HIV infection. Italian Registry of Post-Exposure Prophylaxis.
Lancet, 355 (2000), pp. 1556-1557
[403.]
E.H. Kaplan, R. Heimer.
A model-based estimate of HIV infectivity via needle sharing.
J Acquir Immune Defic Syndr, 5 (1992), pp. 1116-1118
[404.]
J.I. Tokars, R. Marcus, D.H. Culver, C.A. Schable, P.S. McKibben, C.I. Bandea, et al.
Surveillance of HIV infection and zidovudine use among health care workers after occupational exposure to HIV-infected blood. The CDC Cooperative Needlestick Surveillance Group.
Ann Intern Med, 118 (1993), pp. 913-919
[405.]
T.D. Mastro, I. de Vincenzi.
Probabilities of sexual HIV-1 transmission.
AIDS, 10 (1996), pp. 75-82
[406.]
M.H. Katz, J.L. Gerberding.
Postexposure treatment of people exposed to the human immunodeficiency virus through sexual contact or injection-drug use.
N Engl J Med, 336 (1997), pp. 1097-1100
[407.]
Centers for Disease Control and Prevention. Management of possible sexual, injecting-drug-use, or other nonoccupational exposure to HIV, including considerations related to antiretroviral therapy. Public Health Service statement.
MMWR Recomm Rep, 47 (1998), pp. 1-14
[408.]
J.M. Peña, J. Arribas.
Profilaxis postexposición no ocupacional al VIH: ¿espada de dos filos?.
Enferm Infecc Microbiol Clin, 18 (2000), pp. 105-107
[409.]
Roland MD. Prophylaxis following non-occupational exposure to HIV: University of California San Francisco HIV InSite Knowledge, 2001. Disponible en: http://hivinsite.ucsf.edu
[410.]
C. Rabaud, S. Bevilacqua, I. Beguinot, V. Dorvaux, H. Schuhmacher, T. May, et al.
Tolerability of postexposure prophylaxis with zidovudine, lamivudine, and nelfinavir for human immunodeficiency virus infection.
Clin Infect Dis, 32 (2001), pp. 1494-1495
[411.]
E. Bernasconi, J. Jost, B. Ledergerber, B. Hirschel, P. Francioli, P. Sudre.
Antiretroviral prophylaxis for community exposure to the human immunodeficiency virus in Switzerland, 1997-2000.
Swiss Med Wkly, 131 (2001), pp. 433-437
[412.]
Lot F, Larsen C, Baum-Parmentier V, Laporte A. Sexual HIV post-exposure prophylaxis (PEP) in France. 8th Conference on Retroviruses and Opportunistic infections; Chicago, 2001. Resumen 226
[413.]
J.W. Dilley, W.J. Woods, W. McFarland.
Are advances in treatment changing views about high-risk sex?.
N Engl J Med, 337 (1997), pp. 501-502
[414.]
M.H. Katz, S.K. Schwarcz, T.A. Kellogg, J.D. Klausner, J.W. Dilley, S. Gibson, et al.
Impact of highly active antiretroviral treatment on HIV seroincidence among men who have sex with men: San Francisco.
Am J Public Health, 92 (2002), pp. 388-394
[415.]
A. van der Straten, C.A. Gomez, J. Saul, J. Quan, N. Padian.
Sexual risk behaviors among heterosexual HIV serodiscordant couples in the era of post-exposure prevention and viral suppressive therapy.
AIDS, 14 (2000), pp. F47-F54
[416.]
C.R. Waldo, R.D. Stall, T.J. Coates.
Is offering post-exposure prevention for sexual exposures to HIV related to sexual risk behavior in gay men?.
AIDS, 14 (2000), pp. 1035-1039
[417.]
M. Dybul, T.W. Chun, C. Yoder, B. Hidalgo, M. Belson, K. Hertogs, et al.
Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: Effects on virologic, immunologic, and toxicity parameters.
Proc Natl Acad Sci USA, 98 (2001), pp. 15161-15166
[418.]
R.T. Davey, N. Bhat, C. Yoder, T.W. Chun, J.A. Metcalf, R. Dewar, et al.
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression.
Proc Natl Acad Sci USA, 96 (1999), pp. 15109-15114
[419.]
M. Altfeld, B.D. Walker.
Less is more? STI in acute and chronic HIV-1 infection.
Nat Med, 7 (2001), pp. 881-884
[420.]
Parish MA, Raines C, Higgins M, Gallant JE. Treatment Discontinuation in Patients with Marginal Indications for HAART. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; Chicago, 2001. Resumen 673
[421.]
R.T. Davey, R.L. Murphy, F.M. Graziano, S.L. Boswell, A.T. Pavia, M. Cancio, et al.
Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial.
JAMA, 284 (2000), pp. 183-189
[422.]
S. Emery, W.B. Capra, D.A. Cooper, R.T. Mitsuyasu, J.A. Kovacs, P. Vig, et al.
Pooled analysis of 3 randomized, controlled trials of interleukin-2 therapy in adult human immunodeficiency virus type 1 disease.
J Infect Dis, 182 (2000), pp. 428-434
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