Streptococcus agalactiae altamente resistente a fluoroquinolonas

Antecedentes

Streptococcus agalactiae se mantiene sensible a la penicilina, si bien se ha descrito un incremento en la resistencia a otras familias de antimicrobianos como macrólidos y más raramente fluoroquinolonas.

Métodos y resultados

Entre 2003 y 2004 se detectaron dos cepas de S. agalactiae resistentes a fluoroquinolonas, que presentaron mutaciones en parC (Ser₇₉ → Phe) y gyrA (Glu₈₅ → Ala o Glu₈₅ → Lys).

Conclusión

Se describen por primera vez en España cepas de S. agalactiae altamente resistentes a fluoroquinolonas.

Background

Streptococcus agalactiae remains susceptible to penicillin; nevertheless, an increase in the resistance to other antimicrobial families, such as macrolides and more rarely fluoroquinolones, has been described.

Methods

and results. From 2003 to 2004, two fluoroquinolone-resistant S. agalactiae strains were detected. The strains presented one mutation in parC (Ser₇₉ → Phe) and an additional mutation in gyrA (Glu₈₅ → Ala or Glu₈₅ → Lys).

Conclusion

This study describes the first S. agalactiae strains highly resistant to fluoroquinolones in Spain.