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B) Ecografía del caso 2 donde se identifica adenopatía de 2,79<span class="elsevierStyleHsp" style=""></span>cm con pequeños focos de necrosis. C) Fotografía de lámpara de hendidura mostrando granuloma conjuntival que protruye desde el fondo de saco conjuntival inferior del ojo derecho. 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Image (B) corresponds to the Warthin–Starry histochemical staining, revealing microorganisms stained with silver impregnation on the luminal surface of the colonic epithelium, corresponding to spirochetes. Image (C) shows the positive immunohistochemical staining for the antitreponema antibody on the luminal surface of the colonic epithelium. After treatment, image (D) (haematoxylin–eosin) shows a colonic mucosa without the presence of the basophilic layer on the luminal surface of the colonic epithelium. Image (E) confirms the absence of microorganisms with Warthin–Starry histochemical staining.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio Rosales-Castillo, Javier López Hidalgo, Carmen Hidalgo Tenorio" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Antonio" "apellidos" => "Rosales-Castillo" ] 1 => array:2 [ "nombre" => "Javier López" "apellidos" => "Hidalgo" ] 2 => array:2 [ "nombre" => "Carmen Hidalgo" "apellidos" => "Tenorio" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213005X19302253" "doi" => "10.1016/j.eimc.2019.08.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X19302253?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X20300265?idApp=UINPBA00004N" "url" => "/2529993X/0000003800000005/v1_202005080627/S2529993X20300265/v1_202005080627/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2529993X20300708" "issn" => "2529993X" "doi" => "10.1016/j.eimce.2019.05.012" "estado" => "S300" "fechaPublicacion" => "2020-05-01" "aid" => "2034" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Enferm Infecc Microbiol Clin. 2020;38:234-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Implementation models and access to HIV pre-exposure prophylaxis in Spain" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "234" "paginaFinal" => "237" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Modelos de implementación y acceso a la profilaxis preexposición para el VIH en España" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Joan Francesc Mir, Manuel F. 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"apellidos" => "Mazarío" ] 2 => array:2 [ "nombre" => "Pep" "apellidos" => "Coll" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213005X19301867" "doi" => "10.1016/j.eimc.2019.05.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X19301867?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X20300708?idApp=UINPBA00004N" "url" => "/2529993X/0000003800000005/v1_202005080627/S2529993X20300708/v1_202005080627/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Diagnosis at first sight</span>" "titulo" => "Granulomatous conjunctivitis in two young patients" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "238" "paginaFinal" => "239" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Marcos Mozo Cuadrado, Laura Tabuenca del Barrio, Sara Mosquera Pedreiro, Kelly García Guevara" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Marcos Mozo" "apellidos" => "Cuadrado" "email" => array:1 [ 0 => "m.mozo.cuadrado@navarra.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Laura Tabuenca" "apellidos" => "del Barrio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Sara Mosquera" "apellidos" => "Pedreiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Kelly García" "apellidos" => "Guevara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Oftalmología, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Conjuntivitis granulomatosa en 2 pacientes jóvenes" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2124 "Ancho" => 2917 "Tamanyo" => 409500 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Image showing papillary follicular conjunctivitis next to a granuloma with an ulcerated surface in the upper tarsal conjunctiva of the left eye. (B) Ultrasound of case 2 wherein a 2.79<span class="elsevierStyleHsp" style=""></span>cm adenopathy is identified with small foci of necrosis. (C) Slit-lamp photograph showing a conjunctival granuloma protruding from the bottom of the lower conjunctival sac of the right eye. (D) Biopsy of a submandibular adenopathy wherein clustered epithelioid histiocytes suggestive of granulomatous lymphadenitis are identified.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical description of the cases</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Case 1</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 20-year-old patient who referred with a two-week evolution of pink eye, tearing and a foreign body sensation. This was also accompanied by the appearance of an ipsilateral painful preauricular mass. On examination, follicular conjunctivitis was identified, accompanied by an upper tarsal granulomatous lesion (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A), with a mobile and painful preauricular adenopathy also present. Given the clinical suspicion, the patient was asked about any history consistent with the condition and according to what they told us, they sleep with a small cat. General analytical testing and indirect immunofluorescence (IIF) for <span class="elsevierStyleItalic">Bartonella</span> were requested.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case 2</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 3-year-old girl, evaluated for a conjunctival lesion in the right eye and foreign body sensation. According to the patient, she is being studied for painful submandibular adenopathy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B) for which surgical debridement and biopsy have been performed. She presented a right lower tarsal granuloma, with no other findings (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C), and a biopsy of the adenopathy revealed the presence of granulomatous lymphadenitis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D). We did not find anything, despite a detailed epidemiological history of contact with animals.</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Evolution</span><p id="par0015" class="elsevierStylePara elsevierViewall">In case 1, the IIF was positive for anti-<span class="elsevierStyleItalic">Bartonella henselae</span> IgM (titre 1/256) and IgG (1/320), indicative of recent infection. Empirical treatment with macrolides was started (azithromycin 500<span class="elsevierStyleHsp" style=""></span>mg/24<span class="elsevierStyleHsp" style=""></span>h/for 5 days) since follow-up was not possible.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Case number 2 presented serology positive for <span class="elsevierStyleItalic">B. henselae</span> (IIF IgM 1/512 and IgG 1/40). Therefore, treatment with azithromycin and amoxicillin/clavulanic acid, adjusted for weight, was started.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In both cases the evolution was favourable.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Final comments</span><p id="par0030" class="elsevierStylePara elsevierViewall">Parinaud's oculoglandular syndrome is one of the ocular manifestations of what is known as cat-scratch disease (CSD) caused by <span class="elsevierStyleItalic">B. henselae</span>, though it is not the only cause.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> It is estimated that it represents around 6% of cases of CSD and presents a seasonal pattern, predominating in autumn and winter.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> It occurs as a unilateral follicular conjunctivitis frequently associating a tarsal focal granulomatous lesion with necrosis or ulceration and regional adenopathies that may be accompanied by mild general symptoms.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4–7</span></a> It is typically referred to as a unilateral ocular redness with non-purulent epiphora, eyelid oedema and conjunctival lesion along with painful regional adenopathy.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">B. henselae</span> is a gram negative bacillus whose culture is complex, but can be done in enriched media with times of up to four weeks. Likewise, Warthin–Starry staining can be used to demonstrate the presence of the pathogen in blood vessel or lymph node samples.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8,9</span></a> In immunocompetent patients <span class="elsevierStyleItalic">B. henselae</span> produces necrotizing granulomas and microabscesses, while in immunosuppressed patients the response tends to be vasoproliferative in nature.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Infection in humans can go unnoticed, and in some symptomatic cases the epidemiological history of contact with animals may be absent. Clinical suspicion in the presence of positive IgG and IgM antibody titres by IFI is the most common method to establish the diagnosis, although molecular biology techniques have been developed that have a higher specificity.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> As for serology, cross-reactions that occur with other species of <span class="elsevierStyleItalic">Bartonella</span>, especially <span class="elsevierStyleItalic">Bartonella quintana</span>, and which limit its accuracy when identifying the species involved must be taken into account.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Antibiotic treatment in immunocompetent patients is controversial and should be individualized based on the degree of involvement and the characteristics of the patient, although it is always worthwhile in immunosuppressed patients or cases with associated intraocular involvement.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Both erythromycin and doxycycline have shown very favourable responses, and the duration of treatment usually ranges from two to six weeks in immunocompetent patients, and up to four months in immunosuppressed patients.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Azithromycin at a rate of 500<span class="elsevierStyleHsp" style=""></span>mg/24<span class="elsevierStyleHsp" style=""></span>h/for 5 days has been shown to be a safe and effective alternative.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">We believe that an adequate knowledge of the disease allows treatments and diagnostic tests that generate iatrogenesis and unnecessary concern in patients and their families to be avoided. Observation in mild cases with ophthalmologic examinations may be more than sufficient in most cases, although the treatment should be individualized based on the characteristics of the patient. In cases where treatment with azithromycin 500<span class="elsevierStyleHsp" style=""></span>mg/24<span class="elsevierStyleHsp" style=""></span>h/for 5 days is considered to be indicated, it has proven to be a valid regimen.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This study has received no specific funding from public, private or non-profit organizations.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:3 [ "identificador" => "sec0005" "titulo" => "Clinical description of the cases" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Case 1" ] 1 => array:2 [ "identificador" => "sec0015" "titulo" => "Case 2" ] ] ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Evolution" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Final comments" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Funding" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Cuadrado MM, del Barrio LT, Pedreiro SM, Guevara KG. Conjuntivitis granulomatosa en 2 pacientes jóvenes. Enferm Infecc Microbiol Clin. 2020;38:238–239.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2124 "Ancho" => 2917 "Tamanyo" => 409500 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Image showing papillary follicular conjunctivitis next to a granuloma with an ulcerated surface in the upper tarsal conjunctiva of the left eye. (B) Ultrasound of case 2 wherein a 2.79<span class="elsevierStyleHsp" style=""></span>cm adenopathy is identified with small foci of necrosis. (C) Slit-lamp photograph showing a conjunctival granuloma protruding from the bottom of the lower conjunctival sac of the right eye. (D) Biopsy of a submandibular adenopathy wherein clustered epithelioid histiocytes suggestive of granulomatous lymphadenitis are identified.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cat's cratch disease and Parinaud's oculoglandular syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Escarmelle" 1 => "N. 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