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Scientific letter
First case of non-invasive fungal rhinosinusitis by Aspergillus melleus
Primer caso de rinosinusitis fúngica no invasiva por
Octavio Carretero-Vicarioa,
Corresponding author
octaviocarretero91@gmail.com

Corresponding author.
, Isabel Fradejasa, Isabel Meanab, Ana Perez-Ayalaa
a Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid, Spain
b Servicio de Análisis Clínicos, Hospital Universitario 12 de Octubre, Madrid, Spain
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the patient reported persistence of the pain&#44; in addition to hyposmia and difficulty breathing through her nose&#46; A CT scan showed complete expansive occupation of the left sphenoid sinus with posterior wall bone erosion and complete occupation of the maxillary sinus&#44; ethmoid cells and frontal sinus on the left side&#44; with underlying polyp&#46; Six months later the patient had repeat endoscopic nasal-sinus surgery&#44; with removal of purulent material from the left maxillary&#44; sphenoid and ethmoid sinuses&#44; which was sent to pathology and microbiology for testing&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Pathology reported mucoid material rich in eosinophils and the presence of septate hyphae&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Microbiology received three samples of pus drained from the left maxillary&#44; sphenoid and ethmoid sinuses&#44; which were seeded in Sabouraud-chloramphenicol agar &#40;bioMeri&#232;ux&#41; culture media and incubated at 37<span class="elsevierStyleHsp" style=""></span>&#176;C and 30<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; After 72<span class="elsevierStyleHsp" style=""></span>h of incubation&#44; several 4-cm colonies with a yellowish centre and white periphery had grown in the three cultures incubated at 30<span class="elsevierStyleHsp" style=""></span>&#176;C &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Microscopic examination revealed radiate&#44; biseriate conidial heads &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Initially&#44; the identification was carried out using MALDI-TOF mass spectrometry &#40;Bruker Daltonics&#41;&#44; obtaining a score of 1&#46;8 for <span class="elsevierStyleItalic">Aspergillus ochraceus</span>&#46; To confirm this result&#44; the &#946;-tubulin gene was amplified with conventional PCR&#44; which can discriminate between species of <span class="elsevierStyleItalic">Aspergillus</span>&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> and with its subsequent sequencing <span class="elsevierStyleItalic">Aspergillus melleus</span> was definitively identified with 100 &#37; similarity to the sequence deposited in GeneBank&#174; &#40;FJ491523&#46;1&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was discharged home after surgery&#46; She was prescribed antibiotic treatment &#40;amoxicillin-clavulanic acid 875<span class="elsevierStyleHsp" style=""></span>mg&#47;125<span class="elsevierStyleHsp" style=""></span>mg every 8<span class="elsevierStyleHsp" style=""></span>h for 7 days&#41; and nasal lavage with normal saline followed by inhalations of mometasone furoate in each nostril&#46; Four months later&#44; she had made a good recovery&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Aspergillus melleus</span> belongs to the subgenus <span class="elsevierStyleItalic">Circumdati</span>&#44; section <span class="elsevierStyleItalic">Circumdati</span> and the group <span class="elsevierStyleItalic">Aspergillus ochraceus</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a> It is a fungus of ubiquitous distribution&#44; found in soil&#44; plantations or food&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and has the ability to produce proteolytic enzymes<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and insecticidal compounds&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Like other species in the group&#44; it can also produce ochratoxin&#44; although in small quantities&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> To our knowledge&#44; <span class="elsevierStyleItalic">A&#46; melleus</span> has only been described as a human pathogen in certain cases of onychomycosis&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> so the case we describe would be the first case of fungal rhinosinusitis due to <span class="elsevierStyleItalic">A&#46; melleus</span> and the first infection other than an onychomycosis caused by this microorganism&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In terms of therapeutic management&#44; the fact that it was a non-invasive condition in an immunocompetent patient meant that the use of systemic antifungals was not necessary<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#59; the main treatment being the drainage of the mucous material occupying the sinus cavities&#46; Despite this being an immunocompetent patient with no risk factors for an <span class="elsevierStyleItalic">Aspergillus</span> spp&#46; infection&#44; the anatomical alteration of her nasal sinuses in conjunction with the previous surgery may have played a significant role in the infection and proliferation of the fungus&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">By way of conclusion&#44; we would like to emphasise on the one hand the importance of nucleic acid amplification techniques to precisely identify the species of the <span class="elsevierStyleItalic">Aspergillus</span> genus&#44; and on the other&#44; to raise the possibility that <span class="elsevierStyleItalic">A&#46; melleus</span> cases are underdiagnosed&#46; This is primarily due to their low severity&#44; which means that very often only empirical treatment is considered necessary and microbiological diagnosis is not requested&#46; Another reason is the difficulty in establishing a definitive diagnosis with techniques other than nucleic acid amplification&#44; such as microscopy or MALDI-TOF&#44; which are much more widely available in microbiology laboratories&#46;</p></span>"
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