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Axial (A) and coronal (B) contrast-enhanced T1-weighted (W) images show a ring-enhancing lesion (arrow) in the left frontal region, with enhancement along the ventriculostomy tract (B, long arrow). Also, note enhancement of the ependyma (B, short arrow) and surrounding edema (C, arrow). Trace diffusion-weighted image (DWI) shows central brightness in the lesion (D, arrow) and a low ADC indicating restricted diffusion (E). These imaging findings are consistent with brain abscess. Three weeks after antibiotherapy, contrast-enhanced T1W images (F, G) show that the lesion is diminished, with predominantly low signal intensity on a DWI (I) and a high ADC on ADC map (J); these findings suggest clear fluid in the abscess cavity.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mehmet Yasir Pektezel, Ilkay Isikay, Rahsan Gocmen, Ahmet Cagkan Inkaya" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Mehmet Yasir" "apellidos" => "Pektezel" ] 1 => array:2 [ "nombre" => "Ilkay" "apellidos" => "Isikay" ] 2 => array:2 [ "nombre" => "Rahsan" "apellidos" => "Gocmen" ] 3 => array:2 [ "nombre" => "Ahmet Cagkan" "apellidos" => "Inkaya" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X22001162?idApp=UINPBA00004N" "url" => "/2529993X/0000004000000006/v1_202206070547/S2529993X22001162/v1_202206070547/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2529993X2200048X" "issn" => 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frente a SARS-CoV-2 en trabajadores de la salud en un hospital monográfico pediátrico en Madrid (España)" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Eva Escribano Ceruelo, Marco Antonio Espinel Ruíz, Marta Ortega López-Peláez, Bárbara Fernández Garoz, Julia Asensio Antón, Raquel Jiménez García" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Eva" "apellidos" => "Escribano Ceruelo" ] 1 => array:2 [ "nombre" => "Marco Antonio" "apellidos" => "Espinel Ruíz" ] 2 => array:2 [ "nombre" => "Marta" "apellidos" => "Ortega López-Peláez" ] 3 => array:2 [ "nombre" => "Bárbara" "apellidos" => "Fernández Garoz" ] 4 => array:2 [ "nombre" => "Julia" "apellidos" => "Asensio Antón" ] 5 => array:2 [ "nombre" => "Raquel" "apellidos" => "Jiménez García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213005X21000136" "doi" => "10.1016/j.eimc.2020.12.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X21000136?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X2200048X?idApp=UINPBA00004N" "url" => "/2529993X/0000004000000006/v1_202206070547/S2529993X2200048X/v1_202206070547/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Diagnosis at first sight</span>" "titulo" => "Onychomycosis of rare etiology" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "330" "paginaFinal" => "331" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Amparo Valentín-Martín, Noelia Hernández-Pérez, Alicia Romero-Noreña, José Miguel Molina-Moreno" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Amparo" "apellidos" => "Valentín-Martín" "email" => array:1 [ 0 => "valentin_amp@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Noelia" "apellidos" => "Hernández-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Alicia" "apellidos" => "Romero-Noreña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "José Miguel" "apellidos" => "Molina-Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Microbiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Microbiología, Hospital de La Plana, Villarreal, Castellón, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro de Salud de Onda, Departamento de Salud Villarreal, Onda, Castellón, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Onicomicosis de rara etiología" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 538 "Ancho" => 1250 "Tamanyo" => 154845 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Macroscopic appearance, top (right) and bottom (left), of <span class="elsevierStyleItalic">Monascus ruber</span> colonies in Sabouraud chloramphenicol agar.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 68-year-old woman visited her primary care physician due to a lesion in her right index fingernail for the past three months. The lesion was painful and affected the proximal nail bed. It showed no change in colour and was unrelated to prior trauma (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). In addition, it was accompanied by neither regional lymphadenopathy nor systemic symptoms. Her personal history included poorly controlled diabetes mellitus type 2 in the context of morbid obesity having led to gastroparesis, as well as retinopathy and polyneuropathy. She had not recently travelled abroad, and she did not have any pets.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">As onychomycosis was suspected, following cleansing with 70% ethanol, a sample was collected from the deep zone, close to the nail matrix, for mycological examination and seeded in Sabouraud chloramphenicol agar (Becton Dickinson [BD], Heidelberg, Germany) and in Mycosel agar (BD). The patient was prescribed treatment with itraconazole 200 mg every 12 h the first week of the month for three months<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>. After a week of incubation of the culture media at 30 °C, the growth of several colonies of a filamentous fungus was seen in the Sabouraud chloramphenicol agar. The colonies had a velvety texture; from the top, they were greyish-violet at the centre and whitish on the periphery, and from the bottom, they were reddish-brown (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Microscopic examination of the colonies revealed hyaline hyphae featuring conidiophores with chains of smooth, pyriform conidia with a truncate base and round cleistothecia with an intense honey colour (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Based on these characteristics, the fungus was identified as <span class="elsevierStyleItalic">Monascus ruber</span><a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>. Morphological identification was confirmed by means of DNA extraction, amplification and subsequent sequencing of the conserved internal transcribed spacer (ITS) regions using ITS4 and ITS5 primers<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>. The sequence obtained was analysed by means of comparison with those deposited in two public databases, GenBank (United States National Center for Biotechnology Information [NCBI], <a href="http://www.ncbi.nlm.nih.gov">http://www.ncbi.nlm.nih.gov</a>) and MycoBank (<a href="http://www.mycobank.org">http://www.mycobank.org</a>), yielding similarities to the <span class="elsevierStyleItalic">Monascus ruber</span> sequence of 99.61% and 100%, respectively.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Clinical course</span><p id="par0015" class="elsevierStylePara elsevierViewall">The patient returned for a follow-up visit two months later, wherein less dystrophy and nail plate growth with a healthy appearance were observed. Given the patient's favourable clinical course and poor drug tolerance due to gastrointestinal discomfort, a decision was made to stop her antifungal treatment.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Closing remarks</span><p id="par0020" class="elsevierStylePara elsevierViewall">Onychomycosis is a nail infection caused by dermatophytes, non-dermatophytic filamentous fungi and yeasts. Among these causal agents, dermatophytes are the most common. There are several risk factors such as diabetes mellitus, immunosuppression and ageing; in the latter, abnormalities in peripheral circulation, difficulties with personal hygiene, sedentary lifestyle and slower nail growth facilitating fungal invasion are common<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>. Onychomycosis caused by non-dermatophytic fungi is uncommon, yet medically significant given its challenging diagnosis and treatment. These fungi are found in nature as soil saprophytes and plant pathogens. They exhibit rapid growth and a universal distribution. Notable examples of non-dermatophytic fungi that cause onychomycosis are <span class="elsevierStyleItalic">Scopulariopsis</span> spp. and <span class="elsevierStyleItalic">Fusarium</span> spp., followed by species from the genus <span class="elsevierStyleItalic">Aspergillus</span><a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a>. <span class="elsevierStyleItalic">Monascus ruber</span> is an ascomycete belonging to the family Monascaceae that was recently identified as a causal agent of onychomycosis in two patients, one from India and one from Morocco<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a>. Our case is the first one reported in Spain and we believe it must be taken into account as a possible emerging cause of onychomycosis in this country; therefore, we feel it is useful to recognise its macroscopic and microscopic characteristics. While the importance of this condition is often underestimated, infected nails act as a reservoir for infection, which in immunosuppressed patients can cause serious systemic infections. Antifungal treatment of onychomycosis is not simple, as long treatment periods are needed, especially in cases of extensive involvement. A lack of immediate satisfactory effects and the side effects associated with the drugs used result in low rates of compliance. Furthermore, said side effects sometimes require treatment suspension, as in our patient<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,10</span></a>. In both our case and the two cases reported in the literature, infection with <span class="elsevierStyleItalic">Monascus ruber</span> successfully resolved.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Funding</span><p id="par0025" class="elsevierStylePara elsevierViewall">No funding was received for this study.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case report" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Clinical course" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Closing remarks" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Funding" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 5 => array:2 [ "identificador" => "xack609228" "titulo" => "Acknowledgements" ] 6 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Valentín-Martín A, Hernández-Pérez N, Romero-Noreña A, Molina-Moreno JM. Onicomicosis de rara etiología. Enferm Infecc Microbiol Clin. 2022;40:330–331.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 450 "Ancho" => 600 "Tamanyo" => 39961 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Proximal nail bed lesion in right index finger.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 538 "Ancho" => 1250 "Tamanyo" => 154845 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Macroscopic appearance, top (right) and bottom (left), of <span class="elsevierStyleItalic">Monascus ruber</span> colonies in Sabouraud chloramphenicol agar.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 663 "Ancho" => 600 "Tamanyo" => 86249 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Microscopic characteristics of <span class="elsevierStyleItalic">Monascus ruber</span> (40x magnification). Conidiophores with chains of smooth, pyriform conidia with a truncate base and round cleistothecia are seen.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guía práctica de identificación y diagnóstico en micología clínica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Pemán" 1 => "E. Martín-Mazuelos" 2 => "M.C. Rubio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ "edicion" => "2 ed." 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Year/Month | Html | Total | |
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2024 October | 10 | 3 | 13 |
2024 September | 14 | 2 | 16 |
2024 August | 24 | 5 | 29 |
2024 July | 10 | 4 | 14 |
2024 June | 13 | 6 | 19 |
2024 May | 11 | 2 | 13 |
2024 April | 11 | 16 | 27 |
2024 March | 28 | 4 | 32 |
2024 February | 27 | 4 | 31 |
2024 January | 12 | 7 | 19 |
2023 December | 27 | 9 | 36 |
2023 November | 29 | 6 | 35 |
2023 October | 46 | 5 | 51 |
2023 September | 19 | 2 | 21 |
2023 August | 26 | 9 | 35 |
2023 July | 18 | 11 | 29 |
2023 June | 25 | 0 | 25 |
2023 May | 35 | 0 | 35 |
2023 April | 33 | 2 | 35 |
2023 March | 20 | 1 | 21 |
2023 February | 9 | 3 | 12 |
2023 January | 5 | 3 | 8 |
2022 December | 10 | 4 | 14 |
2022 June | 0 | 2 | 2 |