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Inicio Gastroenterología y Hepatología (English Edition) A meta-analysis of Lactate Ringer's solution versus Normal Saline in the treatme...
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Vol. 47. Issue 8.
Pages 876-887 (October 2024)
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Vol. 47. Issue 8.
Pages 876-887 (October 2024)
Review
A meta-analysis of Lactate Ringer's solution versus Normal Saline in the treatment of acute pancreatitis
Un metanálisis de la solución de Ringer con lactato versus solución salina normal en el tratamiento de la pancreatitis aguda
Zhengwang Wanga,, Keru Shib,, Shaojian Mob,c,, Ziang Liub, Jie Yaod,
Corresponding author
dryaojie@yzu.edu.cn

Corresponding author.
a Yangzhou University Medical College, Yangzhou, Jiangsu, China
b Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
c Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
d Department of Hepatobiliary and Pancreatic Surgery, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China
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Table 1. Features of studies.
Table 2. Outcomes of studies.
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Abstract

Fluid resuscitation is an important way in the treatment of acute pancreatitis (AP). This meta-analysis aimed to compare the safety and efficacy of Lactate Ringer's solution (LR) and Normal Saline (NS) in the treatment of patients with acute pancreatitis. Searched in PubMed, Web of Science Core Collection (Clarivate), Embase, Cochrane Library, CNKI, China Wanfang, and China VIP database. All randomized controlled clinical trials (RCTs) were identified. Six studies with 431 patients were included. Compared with NS, LR can significantly reduce the incidence of SIRS at 24h, reduce the length of hospitalization, moderate–severe AP, ICU admission and local complications, especially pancreatic necrosis. It is safe and effective to choose LR for fluid resuscitation in AP, but due to the small number of included studies, multi-center and large-sample RCTs are still needed for further verification.

PROSPERO registration number: CRD42022322788.

Keywords:
Acute pancreatitis
Fluid resuscitation
Lactate Ringer's solution
Meta-analysis
Normal Saline
Resumen

La reanimación con fluidos es una forma importante en el tratamiento de la pancreatitis aguda (PA). Este metaanálisis tuvo como objetivo comparar la seguridad y eficacia de la solución de Ringer de lactato (LR) y la solución salina normal (NS) en el tratamiento de pacientes con pancreatitis aguda. Se realizaron búsquedas en PubMed, Web of Science Core Collection (Clarivate), Embase, Cochrane Library, CNKI, China Wanfang y China VIP database. Se identificaron todos los ensayos clínicos controlados aleatorios (ECA); se incluyeron seis estudios con 431 pacientes. En comparación con la NS, la LR puede reducir significativamente la incidencia de SIRS a las 24 horas, reducir la duración de la hospitalización, la PA moderada-grave, el ingreso en la UCI y las complicaciones locales, especialmente la necrosis pancreática. Es seguro y eficaz elegir LR para la reanimación con fluidos en la AP, pero debido al pequeño número de estudios incluidos, todavía se necesitan ECA multicéntricos y de muestra grande para una verificación adicional.

Palabras clave:
Pancreatitis aguda
Reanimación con fluidos
Solución de Ringer de lactato
Metaanálisis
Solución salina normal

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