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Inicio Gastroenterología y Hepatología (English Edition) Survey on initial management of acute pancreatitis in Latin America
Journal Information
Vol. 46. Issue 8.
Pages 603-611 (October 2023)
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Vol. 46. Issue 8.
Pages 603-611 (October 2023)
Original article
Survey on initial management of acute pancreatitis in Latin America
Encuesta sobre el manejo inicial de la pancreatitis aguda en América Latina
Núria Lluísa,
Corresponding author
nurialluisv@gmail.com

Corresponding author.
, Horacio Asbuna, Sandra Bassob, Natalia Corzo-Zamorac, Andrés Gelrudd, Edson Guzmán-Calderóne, Edgard E. Lozada-Hernándezf, Carla Mancillag, Rodrigo Mansilla-Vivarh,i, Analía V. Pasquaj, Mario Peláez-Lunak,l, Guido Villa-Gómez Roigm, Pedro Zapatern,o, Félix Lluísn, Eva Vaquerop, José Manuel Ramian,q,, Enrique de Madarian,r,
a Division of Hepatobiliary and Pancreas Surgery, Miami Cancer Institute, Miami, FL, USA
b Department of Gastroenterology, Bonorino Udaondo Hospital, Buenos Aires, Argentina
c Department of Gastroenterology, Bolivian Japanese Bolivian Gastroenterological Institute, Cochabamba, Bolivia
d Pancreatic Disease Center, Interventional Endoscopy, Miami Cancer Institute, Gastro Health, Miami, FL, USA
e Gastroenterology Unit, Edgardo Rebagliati Martins National Hospital, Anglo-American Clinic, and School of Medicine of the Peruvian University of Applied Sciences, Lima, Peru
f General Surgery, Department of Diseases of the Digestive Tract, Regional Hospital of High Specialty of Bajío, Guanajuato, Mexico
g Gastroenterology Section and Critical Care Unit, University of Chile Clinical Hospital, Santiago, Chile
h Digestive Endoscopy Unit, Puerto Montt Hospital, Puerto Montt, Chile
i University San Sebastian, Chile
j Department of Gastroenterology, Italian Hospital of Buenos Aires, Buenos Aires, Argentina
k Research Division, School of Medicine, National Autonomous University of Mexico, Mexico
l Department of Gastroenterology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico
m Digestive Endoscopy Unit, Unigastro, La Paz, Bolivia
n Health and Biomedical Research Institute of Alicante (ISABIAL), Alicante, Spain
o CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
p Gastroenterology Department, Hospital Clínic, University of Barcelona, CIBERehd IDIBAPS, Barcelona, Spain
q Department of Surgery, Dr. Balmis General University Hospital, Alicante, Spain
r Department of Gastroenterology, Dr. Balmis General University Hospital, Alicante, Spain
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Tables (2)
Table 1. Participants who completed the survey by Latin American country.
Table 2. Demographic and professional characteristics of participants in Latin America and rest of the world.
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Additional material (1)
Abstract
Objective

The population of Latin America harbors the highest incidence of gallstones and acute biliary pancreatitis, yet little is known about the initial management of acute pancreatitis in this large geographic region.

Participants and methods

We performed a post hoc analysis of responses from physicians based in Latin America to the international multidisciplinary survey on the initial management of acute pancreatitis. The questionnaire asked about management of patients during the first 72h after admission, related to fluid therapy, prescription of prophylactic antibiotics, feeding and nutrition, and timing of cholecystectomy. Adherence to clinical guidelines in this region was compared with the rest of the world.

Results

The survey was completed by 358 participants from 19 Latin American countries (median age, 39 years [33–47]; women, 27.1%). The proportion of participants in Latin America vs. the rest of the world who chose non-compliant options with clinical guidelines were: prescription of fluid therapy rate other than moderate (42.2% vs 34.3%, P=.02); prescription of prophylactic antibiotics for severe (10.6% vs 18.0%, P=.002), necrotizing (28.5% vs 36.9%, P=.008), or systemic inflammatory response syndrome-associated (21.2% vs 30.6%, P=.002) acute pancreatitis; not starting an oral diet to patients with oral tolerance (77.9% vs 71.1%, P=.02); and delayed cholecystectomy (16.2% vs 33.8%, P<.001).

Conclusions

Surveyed physicians in Latin America are less likely to prescribe antibiotics and to delay cholecystectomy when managing patients in the initial phase of acute pancreatitis compared to physicians in the rest of the world. Feeding and nutrition appear to require the greatest improvement.

Keywords:
Fluid therapy
Antibiotic prophylaxis
Feeding
Nutrition
Cholecystectomy timing
Ursodeoxycholic acid
Abbreviations:
ICU
IQR
SIRS
Resumen
Objetivo

La población de América Latina alberga la mayor incidencia de cálculos biliares y pancreatitis biliar aguda, sin embargo, poco se sabe sobre el manejo inicial de la pancreatitis aguda en esta extensa región geográfica.

Participantes y métodos

Se realizó un análisis post hoc de las respuestas de los médicos de América Latina a la encuesta internacional multidisciplinar sobre el tratamiento inicial de la pancreatitis aguda. En el cuestionario se preguntaba por el manejo de los pacientes durante las primeras 72 h tras el ingreso, en relación con la fluidoterapia, la prescripción de antibióticos profilácticos, la alimentación y nutrición y el momento de la colecistectomía. La adherencia a las guías clínicas en esta región se comparó con la del resto del mundo.

Resultados

La encuesta fue completada por 358 participantes de 19 países latinoamericanos (mediana de edad, 39 años [33-47]; mujeres, 27,1%). La proporción de participantes de América Latina frente al resto del mundo que eligieron opciones no conformes con las guías clínicas fueron: prescripción de fluidoterapia en casos distintos de los moderados (42,2 vs. 34,3%, p = 0,02); prescripción de antibióticos profilácticos en casos graves (10,6 vs. 18%, p = 0,002); necrotizante (28,5 vs. 36,9%, p = 0,008) o asociada al síndrome de respuesta inflamatoria sistémica (21,2 vs. 30,6%, p = 0,002); no inicio de dieta oral en pacientes con tolerancia oral (77,9 vs. 71,1%, p = 0,02); y retraso de la colecistectomía (16,2 vs. 33,8%, p < 0,001).

Conclusiones

Los médicos encuestados en América Latina son menos propensos a prescribir antibióticos y a retrasar la colecistectomía cuando tratan a pacientes en la fase inicial de la pancreatitis aguda, en comparación con los médicos del resto del mundo. La alimentación y la nutrición parecen requerir las mayores mejoras.

Palabras clave:
Fluidoterapia
Profilaxis antibiótica
Alimentación
Nutrición
Momento de la colecistectomía
Ácido ursodesoxicólico

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