array:24 [ "pii" => "S2444382418301305" "issn" => "24443824" "doi" => "10.1016/j.gastre.2018.07.003" "estado" => "S300" "fechaPublicacion" => "2018-08-01" "aid" => "1187" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2017" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2018;41:440-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1 "HTML" => 1 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0210570517301991" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2017.08.007" "estado" => "S300" "fechaPublicacion" => "2018-08-01" "aid" => "1187" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2018;41:440-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 289 "formatos" => array:2 [ "HTML" => 155 "PDF" => 134 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científica</span>" "titulo" => "La noradrenalina como tratamiento médico alternativo a la terlipresina en el manejo del síndrome hepatorrenal tipo 1" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "440" "paginaFinal" => "441" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Noradrenaline as an alternative medical treatment to terlipressin in the management of hepatorenal syndrome type 1" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 745 "Ancho" => 1827 "Tamanyo" => 109692 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evolutivo de la creatinina y tratamientos administrados durante la hospitalización.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carmen Sendra, María del Pilar Silva Ruiz, María Teresa Ferrer Rios, José Carlos Alarcón García, Juan Manuel Pascasio Acevedo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Carmen" "apellidos" => "Sendra" ] 1 => array:2 [ "nombre" => "María del Pilar" "apellidos" => "Silva Ruiz" ] 2 => array:2 [ "nombre" => "María Teresa" "apellidos" => "Ferrer Rios" ] 3 => array:2 [ "nombre" => "José Carlos" "apellidos" => "Alarcón García" ] 4 => array:2 [ "nombre" => "Juan Manuel" "apellidos" => "Pascasio Acevedo" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2444382418301305" "doi" => "10.1016/j.gastre.2018.07.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382418301305?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570517301991?idApp=UINPBA00004N" "url" => "/02105705/0000004100000007/v1_201808030407/S0210570517301991/v1_201808030407/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S244438241830124X" "issn" => "24443824" "doi" => "10.1016/j.gastre.2018.06.011" "estado" => "S300" "fechaPublicacion" => "2018-08-01" "aid" => "1184" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2018;41:442-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1 "HTML" => 1 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Leukocytoclastic vasculitis complicating adalimumab therapy for Crohn's disease: Report of three cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "442" "paginaFinal" => "443" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vasculitis leucocitoclástica como complicación del adalimumab en el tratamiento de la enfermedad de Crohn: relato de tres casos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 791 "Ancho" => 2333 "Tamanyo" => 150477 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Palpable purpuric lesions on both legs and feet in patients from cases 1 (A and B) and 3 (C).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos Bernardes, Diana Carvalho, Joana Saiote, Jaime Ramos" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Carlos" "apellidos" => "Bernardes" ] 1 => array:2 [ "nombre" => "Diana" "apellidos" => "Carvalho" ] 2 => array:2 [ "nombre" => "Joana" "apellidos" => "Saiote" ] 3 => array:2 [ "nombre" => "Jaime" "apellidos" => "Ramos" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0210570517301966" "doi" => "10.1016/j.gastrohep.2017.08.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570517301966?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S244438241830124X?idApp=UINPBA00004N" "url" => "/24443824/0000004100000007/v2_201810040621/S244438241830124X/v2_201810040621/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2444382418301275" "issn" => "24443824" "doi" => "10.1016/j.gastre.2018.04.021" "estado" => "S300" "fechaPublicacion" => "2018-08-01" "aid" => "1273" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Gastroenterol Hepatol. 2018;41:432-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Benefit of an electronic medical record-based alarm in the optimization of stress ulcer prophylaxis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "432" "paginaFinal" => "439" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Beneficio de una alarma electrónica de la historia clínica en la optimización de la profilaxis de la úlcera por estrés" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2071 "Ancho" => 2294 "Tamanyo" => 288572 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Patient selection: flow chart in pre-intervention and post-intervention periods.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Emanuel José Saad, Marianela Bedini, Ana Florencia Becerra, Gustavo Daniel Martini, Jacqueline Griselda Gonzalez, Andrea Bolomo, Luciana Castellani, Silvana Quiroga, Cristian Morales, James Leathers, Domingo Balderramo, Ricardo Arturo Albertini" "autores" => array:12 [ 0 => array:2 [ "nombre" => "Emanuel José" "apellidos" => "Saad" ] 1 => array:2 [ "nombre" => "Marianela" "apellidos" => "Bedini" ] 2 => array:2 [ "nombre" => "Ana Florencia" "apellidos" => "Becerra" ] 3 => array:2 [ "nombre" => "Gustavo Daniel" "apellidos" => "Martini" ] 4 => array:2 [ "nombre" => "Jacqueline Griselda" "apellidos" => "Gonzalez" ] 5 => array:2 [ "nombre" => "Andrea" "apellidos" => "Bolomo" ] 6 => array:2 [ "nombre" => "Luciana" "apellidos" => "Castellani" ] 7 => array:2 [ "nombre" => "Silvana" "apellidos" => "Quiroga" ] 8 => array:2 [ "nombre" => "Cristian" "apellidos" => "Morales" ] 9 => array:2 [ "nombre" => "James" "apellidos" => "Leathers" ] 10 => array:2 [ "nombre" => "Domingo" "apellidos" => "Balderramo" ] 11 => array:2 [ "nombre" => "Ricardo Arturo" "apellidos" => "Albertini" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0210570518301390" "doi" => "10.1016/j.gastrohep.2018.04.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570518301390?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382418301275?idApp=UINPBA00004N" "url" => "/24443824/0000004100000007/v2_201810040621/S2444382418301275/v2_201810040621/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Noradrenaline as an alternative medical treatment to terlipressin in the management of hepatorenal syndrome type 1" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "440" "paginaFinal" => "441" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carmen Sendra, María del Pilar Silva Ruiz, María Teresa Ferrer Rios, José Carlos Alarcón García, Juan Manuel Pascasio Acevedo" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Carmen" "apellidos" => "Sendra" "email" => array:1 [ 0 => "csendra.fernandez@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "María del Pilar" "apellidos" => "Silva Ruiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "María Teresa" "apellidos" => "Ferrer Rios" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "José Carlos" "apellidos" => "Alarcón García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Juan Manuel" "apellidos" => "Pascasio Acevedo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "UGC Aparato Digestivo, Hospital Universitario Virgen del Rocío, Sevilla, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "UGC Aparato Digestivo, Hospital Juan Ramón Jiménez, Huelva, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La noradrenalina como tratamiento médico alternativo a la terlipresina en el manejo del síndrome hepatorrenal tipo 1" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 797 "Ancho" => 1737 "Tamanyo" => 110949 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Creatinine evolution after introducing noradrenaline.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Type 1 hepatorenal syndrome (HRS) is a form of functional renal failure secondary to splanchnic vasodilation and intense renal vasoconstriction in people with advanced liver disease. Due to its high mortality rate, it is an indication for liver transplantation. Various splanchnic vasoconstrictors are used as a bridge-to-transplantation, with terlipressin being the most studied.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 62-year-old female with alcoholic liver cirrhosis, who was admitted in October 2014 with ascites and kidney failure after a slow post-operative recovery following an umbilical hernia (Child-Pugh B9, MELD 25). After ruling out other causes, type 1 HRS was diagnosed, with creatinine levels of 3.59<span class="elsevierStyleHsp" style=""></span>mg/dl, having had a baseline value of 0.65<span class="elsevierStyleHsp" style=""></span>mg/dl. The patient's ascitic fluid showed no signs of spontaneous bacterial peritonitis (SBP) and treatment with intravenous albumin and terlipressin (1<span class="elsevierStyleHsp" style=""></span>mg every 4<span class="elsevierStyleHsp" style=""></span>h i.v.) was initiated. However, the onset of diarrhoea and abdominal cramps led to the withdrawal thereof after two attempts on consecutive days. Later, with creatinine levels of 3.29<span class="elsevierStyleHsp" style=""></span>mg/dl, treatment and monitoring was initiated with albumin (1<span class="elsevierStyleHsp" style=""></span>g/kg on the first day, then 40<span class="elsevierStyleHsp" style=""></span>g every 2<span class="elsevierStyleHsp" style=""></span>h) and a continuous intravenous noradrenaline perfusion. The starting dose was 0.3<span class="elsevierStyleHsp" style=""></span>mg/h (0.1<span class="elsevierStyleHsp" style=""></span>μg/kg/min) and this was adjusted based on the patient's blood pressure and diuresis, with the aim of increasing her mean blood pressure by at least 10<span class="elsevierStyleHsp" style=""></span>mmHg, for which she required a maximum dose of 0.9<span class="elsevierStyleHsp" style=""></span>mg/h. Her response was favourable and after three days, following a 36% reduction in creatinine levels (2.0<span class="elsevierStyleHsp" style=""></span>mg/dl), the perfusion was suspended and oral midodrine (7.5<span class="elsevierStyleHsp" style=""></span>mg every 8<span class="elsevierStyleHsp" style=""></span>h) and subcutaneous octreotide (100<span class="elsevierStyleHsp" style=""></span>μg every 8<span class="elsevierStyleHsp" style=""></span>h) initiated alongside albumin, with a view to her continuing treatment on an outpatient basis. However, these drugs were suspended three days later due to inefficacy (creatinine 3.24<span class="elsevierStyleHsp" style=""></span>mg/dl). Treatment with terlipressin was resumed and withdrawn once more due to intolerance (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Noradrenaline was then reintroduced, being the only treatment to demonstrate good tolerability and efficacy. It was withdrawn due to a complete response after four days (creatinine<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>1.5<span class="elsevierStyleHsp" style=""></span>mg/dl), with no side effects, and resumed on two subsequent occasions due to relapse, for 5 and 10 days, until a creatinine value of 0.96<span class="elsevierStyleHsp" style=""></span>mg/dl was obtained (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Ten days after being suspended for the last time, the patient was discharged with creatinine levels of 0.70<span class="elsevierStyleHsp" style=""></span>mg/dl. Two months later, she received a liver transplant.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">HRS is the third most common cause of deteriorating renal function in patients with cirrhosis and ascites (20%), behind prerenal failure (48%) and acute tubular necrosis (32%).<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> In type 1 HRS, this decline is fast, generally occurring after a precipitating factor, which in our case was the patient's slow post-operative recovery following an umbilical hernia. From a physiological and pathological point of view, in cirrhotic patients, splanchnic vasodilation, the activation of compensatory vasoconstrictors and a decline in heart function are all conducive to developing the condition. The treatment of choice is liver transplantation, owing to its high mortality rate. Splanchnic vasoconstrictors increase the number of patients who survive while awaiting transplantation and also improve their prognosis thereafter.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> In Europe, the most widely-used vasoconstrictor is terlipressin, the efficacy of which has been proven in placebo-controlled studies.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> However, it is not available in many countries. Among others, diarrhoea and abdominal cramps are commonly described side effects which make it difficult to tolerate. At present, however, there is a controlled study published in 2016, where terlipressin given by continuous infusion was better tolerated at lower doses than those required in boluses.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Alpha-adrenergic drugs (noradrenaline, midodrine) constitute an alternative treatment if terlipressin is not available or in cases such as ours, due to intolerance or inefficacy. Noradrenaline is available worldwide and is cheaper than terlipressin. Its efficacy in type 1 HRS was studied for the first time in 2002. Three studies have been carried out to compare the efficacy of noradrenaline versus terlipressin in type 1 HRS, along with one other in type 2 HRS. However, no strategy has proven superior.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5–8</span></a> There are no controlled, vasoconstrictor-free studies assessing the efficacy of noradrenaline. The drug has been linked to fewer adverse effects, primarily due to the frequency with which patients treated with terlipressin suffer abdominal symptoms.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a> From a cardiovascular point of view, they have been shown to be equally safe. Patients treated with noradrenaline seem to present a milder decline in their MELD score than those treated with terlipressin, due to a supposed deterioration in liver function as a result of decreasing hepatic blood flow, without significant hepatic ischaemia being observed.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">All of the studies make reference to terlipressin's higher cost.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Only one found this strategy to be cheaper, having considered not only the price of the drug but also the cost associated with patients staying at specialist units, which noradrenaline requires.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, noradrenaline is a safe and effective alternative in the treatment of type 1 HRS. It is also more widely available and has fewer adverse effects. More studies are needed to clarify whether or not the added cost of administering noradrenaline at intensive care units makes the strategy the most cost-effective.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Sendra C, Silva Ruiz MP, Ferrer Rios MT, Alarcón García JC, Pascasio Acevedo JM. La noradrenalina como tratamiento médico alternativo a la terlipresina en el manejo del síndrome hepatorrenal tipo 1. Gastroenterol Hepatol. 2018;41:440–441.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 735 "Ancho" => 1831 "Tamanyo" => 108844 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Creatinine evolution and treatments administered during hospital stay.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 797 "Ancho" => 1737 "Tamanyo" => 110949 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Creatinine evolution after introducing noradrenaline.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute renal failure in patients with cirrhosis: perspectives in the age of MELD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Moreau" 1 => "D. Lebrec" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jhep.2003.50084" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2003" "volumen" => "37" "paginaInicial" => "233" "paginaFinal" => "243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12540770" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis and management of hepatorenal syndrome in patients with cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Angeli" 1 => "C. Merkel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2008.01.010" "Revista" => array:7 [ "tituloSerie" => "J Hepatol" "fecha" => "2008" "volumen" => "48" "numero" => "suppl. 1" "paginaInicial" => "S93" "paginaFinal" => "S103" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18304678" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective, randomized, double blind, placebo controlled trial of terlipressin for type 1 hepatorenal syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Sanyal" 1 => "T. Boyer" 2 => "G. Garcia-Tsao" 3 => "F. Regenstein" 4 => "L. Rossaro" 5 => "P. Teuber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hepatology" "fecha" => "2006" "volumen" => "44" "numero" => "suppl." "paginaInicial" => "694A" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terlipressin given by continuous intravenous infusion versus intravenous boluses in the treatment of hepatorenal syndrome: a randomized controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Cavallin" 1 => "S. Piano" 2 => "A. Romano" 3 => "S. Fasolato" 4 => "A.C. Frigo" 5 => "G. Benetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.28396" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2016" "volumen" => "63" "paginaInicial" => "983" "paginaFinal" => "992" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26659927" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An open label, pilot, randomized controlled trial of noradrenaline versus terlipressin in the treatment of type 1 hepatorenal syndrome and predictors of response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Sharma" 1 => "A. Kumar" 2 => "B.C. Shrama" 3 => "S.K. Sarin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1572-0241.2008.01828.x" "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2008" "volumen" => "103" "paginaInicial" => "1689" "paginaFinal" => "1697" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18557715" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noradrenalin vs terlipressin in patients with hepatorenal syndrome: a prospective, randomized, unblinded, pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Alessandria" 1 => "A. Ottobrelli" 2 => "W. Debernardi-Venon" 3 => "L. Todros" 4 => "M.T. Cerenzia" 5 => "S. Martini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2007.04.010" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2007" "volumen" => "47" "paginaInicial" => "499" "paginaFinal" => "505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17560680" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noradrenaline vs. terlipressin in the treatment of hepatorenal syndrome: a randomized study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Singh" 1 => "S. Ghosh" 2 => "B. Singh" 3 => "P. Kumar" 4 => "N. Sharma" 5 => "A. Bhalla" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2012.01.012" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2012" "volumen" => "56" "paginaInicial" => "1293" "paginaFinal" => "1298" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22322237" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noradrenaline vs terlipressin in the treatment of type 2 hepatorenal syndrome: a randomized pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Ghosh" 1 => "N.S. Choudhary" 2 => "A.K. Sharma" 3 => "B. Singh" 4 => "P. Kumar" 5 => "R. Agarwal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/liv.12179" "Revista" => array:6 [ "tituloSerie" => "Liver Int" "fecha" => "2013" "volumen" => "33" "paginaInicial" => "1187" "paginaFinal" => "1193" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23601499" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terlipressin versus norepinephrine in the treatment of hepatorenal syndrome: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.P. Nassar Junior" 1 => "A.Q. Farias" 2 => "L.A. d’Albuquerque" 3 => "F.J. Carrilho" 4 => "L.M. Malbouisson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0107466" "Revista" => array:5 [ "tituloSerie" => "PLOS ONE" "fecha" => "2014" "volumen" => "9" "paginaInicial" => "e107466" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25203311" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terlipressin versus noradrenaline in the treatment of hepatorenal syndrome: systematic review with meta-analysis and full economic evaluation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.Z. Mattos" 1 => "A.A. Mattos" 2 => "R.A. Ribeiro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MEG.0000000000000537" "Revista" => array:6 [ "tituloSerie" => "Eur J Gastroenterol Hepatol" "fecha" => "2016" "volumen" => "28" "paginaInicial" => "345" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26649801" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/24443824/0000004100000007/v2_201810040621/S2444382418301305/v2_201810040621/en/main.assets" "Apartado" => array:4 [ "identificador" => "48446" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/24443824/0000004100000007/v2_201810040621/S2444382418301305/v2_201810040621/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382418301305?idApp=UINPBA00004N" ]
Journal Information
Share
Download PDF
More article options
Scientific letter
Noradrenaline as an alternative medical treatment to terlipressin in the management of hepatorenal syndrome type 1
La noradrenalina como tratamiento médico alternativo a la terlipresina en el manejo del síndrome hepatorrenal tipo 1