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Gastritis cystica profunda mimicking a GIST – A diagnostic challenge
Gastritis cystica profunda simulando GIST – un caso de desafío diagnóstico
Joana Rita Carvalhoa,
Corresponding author
joana.rita.carvalho@gmail.com

Corresponding author.
, Ana Catarina Quadrosb, Liliane Meirelesa, Irina Alvesb, Paula Moura dos Santosa, Fátima Serejoa, Cristina Ferreirab, José Paulo Freirec, José Velosaa
a Department of Gastroenterology and Hepatology, North Lisbon Hospital Center, Portugal
b Department of Pathology, North Lisbon Hospital Center, Portugal
c Department of General Surgery, North Lisbon Hospital Center, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gastritis cystica profunda &#40;GCP&#41; is a rare hyperplastic lesion with unclear pathogenesis histologically characterized by the presence of gastric glands in the submucosa and even muscularis propria of the stomach with normal overlying mucosa&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> There are two histological patterns of gastritis cystica poliposa&#58; gastritis cystica superficialis&#44; in which cystic glands are limited to the mucosal layer&#59; and GCP in which the cystic lesion locates within the submucosa and muscularis propria&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Clinical manifestations of GCP are variable and can include gastrointestinal bleeding&#44; epigastric pain and weight loss&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> An unspecified mucosal insult or injury is widely accepted as etiological mechanism but the pathophysiology is unknown&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;4</span></a> We present a case of acute gastrointestinal bleeding caused by gastritis cystica profunda mimicking a gastrointestinal stromal tumor in a patient without previous gastric surgery&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 67 year-old man was admitted for melena during 4 days associated with syncope&#46; He had a previous history of atrial fibrillation and was medicated with warfarin&#46; At admission&#44; he was hemodynamically stable and had no abdominal pain&#46; Laboratory tests revealed normocytic anemia with hemoglobin 8&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dl &#40;previous value&#58; 13&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41; and an INR of 2&#46;3&#46; Upper gastrointestinal endoscopy &#40;UGIE&#41; revealed a 40<span class="elsevierStyleHsp" style=""></span>mm polypoid lesion in the gastric body with normal mucosa surface and a central 15<span class="elsevierStyleHsp" style=""></span>mm ulcerated bleeding as which was very suggestive of a gastrointestinal stromal tumor &#40;GIST&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no esophageal or duodenal visible bleeding lesions&#46; Biopsies performed during UGIE revealed aspects of chronic active gastritis and <span class="elsevierStyleItalic">Helicobacter pylori</span> was identified&#46; Upper endoscopic ultrasonography &#40;EUS&#41; showed 40<span class="elsevierStyleHsp" style=""></span>mm submucosal a hypoechogenic and heterogeneous mass with cystic areas and no perilesional adenopathies&#46; The EUS findings could also correspond to a GIST&#46; EUS guided fine-needle aspiration &#40;FNA&#41; using 19 gauge needle was preformed but the sample was insufficient for evaluation&#46; A full body computed tomography was performed and revealed a 4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>cm gastric intraluminal lesion without signs of invasion or metastatic disease&#46; The diagnosis of a gastric GIST was assumed and the patient was proposed to surgical resection of the lesion&#46; Macroscopically&#44; a polypoid lesion with a nodular surface and a central ulcer was observed&#44; with multiple cysts and solid areas on cross-section &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Histologically &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; the gastric mucosa showed focal lesions of chronic atrophic gastritis with activity&#44; hemorrhage and ulceration&#44; the submucosa and muscular propria displayed an abundant cystically dilated pyloric-type and foveolar-type glandular proliferation&#44; without mitoses or atypia&#59; surrounding the glands there was a thin layer of lamina propria and fibromuscular hyperplasia&#46; The diagnosis of Gastritis cystica profunda was made&#46; Surgical margins were free of lesion&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">In the majority of reported cases&#44; GCP occurs in patients with a history of gastric surgery&#44; in particular Billroth II procedure&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;3</span></a> It is unclear if it is secondary to chronic inflammation as consequence of duodenal reflux&#44; foreign body reaction or ischemic injury as a result of the surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2&#44;5&#44;6</span></a> Nevertheless&#44; the interruption of the muscularis mucosae appears to allow migration of epithelial cells into the submucosal layer and subsequent cystic dilation&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;7</span></a> In the unoperated stomach&#44; the cause may be congenital in origin in patients with no prior gastric ulceration or trauma history&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> It is more common in men and most frequently develops in the gastric body&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> as seen in this case&#46; Our patient had a history of chronic atrophic gastritis with <span class="elsevierStyleItalic">H&#46; pylori</span> infection which in this case can be considered as a possible etiological factor&#46; The presentation symptoms are not specific and&#44; endoscopically it is impossible to differentiate from other entities like polyps or GIST&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> As biopsy samples are restricted to the spared mucosal the results are often not diagnostic&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;8</span></a> CT can show a heterogeneously iso- to hypoattenuating intraluminal lesion with multiple small cysts but the appearance may be similar to GIST&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;9</span></a> On EUS&#44; GCP can appear as a polymorphic&#44; homogeneous cystic mass with a minimal solid component within the gastric mucosae which is also not specific of GCP&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;3</span></a> However&#44; the accuracy of EUS-FNA with immunostaining in preoperative GIST&#44; diagnosis has been reported at 91&#37;&#8211;100&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Some patients might have to undergo gastric resection when it is impossible to make a definite diagnosis with radiologic study or endoscopic biopsy&#44; as seen in this case&#46; Case reports have revealed the possibility of a malignant transformation from GCP&#44; even in an unoperated stomach&#44; but the incidence of malignancy in GCP patients remains unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Epstein&#8211;Barr virus might have a role as a premalignant factor in cancer tissue with GCP&#46;<span class="elsevierStyleSup">10</span> Given the lack of a pathognomonic endoscopic or radiographic appearance of GCP&#44; diagnostic and surveillance guidelines are not available and further studies are required&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">No funding&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">No conflicts of interest&#46;</p></span></span>"
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Article information
ISSN: 24443824
Original language: English
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2021 December 26 16 42
2021 November 22 9 31
2021 October 71 21 92
2021 September 41 12 53
2021 August 25 15 40
2021 July 13 6 19
2021 June 17 11 28
2021 May 21 5 26
2021 April 25 11 36
2021 March 16 6 22
2021 February 22 12 34
2021 January 37 16 53
2020 December 12 13 25
2020 November 14 9 23
2020 October 7 9 16
2020 September 16 8 24
2020 August 9 4 13
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos