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Inicio Medicina Clínica (English Edition) Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-a...
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Vol. 152. Issue 12.
Pages 473-481 (June 2019)
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Vol. 152. Issue 12.
Pages 473-481 (June 2019)
Original article
Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials
Efecto de los probióticos en los perfiles lipídicos en adultos con hipercolesterolemia: metaanálisis de ensayos clinicos aleatorizados
Rui Moa,b, Xingwei Zhanga,b, Yunsheng Yangb,a,
Corresponding author
sunny301ddc@126.com

Corresponding author.
a School of Medicine, Nankai University, Tianjin, China
b Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China
Article information
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Tables (4)
Table 1. Characteristics of included trials.
Table 2. Methodological quality assessment of included studies.
Table 3. Subgroup analyses of effect of probiotics on TC and LDL-C.
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Abstract
Background

Recent clinical studies have yielded controversial results regarding the effect of probiotics on lipid profiles. To assess the efficacy of probiotics in lowering serum lipid concentrations, we conducted a meta-analysis of randomized controlled trials (RCTs).

Methods

Literature from the PubMed, Embase and Cochrane databases were searched and screened. The effects of probiotics on lipid profiles were assessed by mean difference (MD) and 95% confidence interval (CI). All included studies were analyzed using Review Manager 5.3 (Cochrane Collaboration, 2014).

Results

A total of 19 RCTs, including 967 participants, met the inclusion criteria. Probiotic interventions reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) compared to controls (placebo or no treatment) by −0.25mmol/L (95% CI: −0.39, −0.12) and −0.17mmol/L (95% CI: −0.25, −0.09), respectively. No significant effects of probiotics on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were found. The effects of probiotics on decreasing TC and LDL-C levels were greater for longer intervention times, certain probiotic strains, and in younger mildly hypercholesterolaemic subjects.

Conclusion

This meta-analysis revealed that the use of probiotics can significantly lower TC and LDL-C levels in hypercholesterolaemic adults, which brings hope for reducing the risk factors for developing cardiovascular disease.

Keywords:
Probiotics
Hypercholesterolaemia
Meta-analysis
Resumen
Antecedentes

Los resultados obtenidos por estudios clínicos recientes sobre el efecto de los probióticos en los perfiles lipídicos han generado cierta controversia. Para evaluar la eficacia de los probióticos en la reducción de las concentraciones séricas de lípidos, se realizó un metaanálisis de estudios comparativos aleatorizados (ECA).

Métodos

Se realizó una búsqueda y posterior cribado bibliográfico en las bases de datos PubMed, Embase y Cochrane. Se evaluaron los efectos de los probióticos en los perfiles de lípidos mediante la diferencia de medias (DM) y el intervalo de confianza (IC) del 95%. Todos los estudios incluidos se analizaron con Review Manager 5.3 (Cochrane Collaboration, 2014).

Resultados

Cumplieron con los criterios de inclusión un total de 19 ECA, que incluyeron 967 participantes. Las intervenciones probióticas redujeron el colesterol total (CT) y el colesterol de lipoproteínas de baja densidad (c-LDL) en −0,25mmol/l (IC 95%: −0,39, −0,12) y −0,17mmol/l (IC 95%: −0,25, −0,09), respectivamente, en comparación con los controles (placebo o ningún tratamiento). No se observaron efectos significativos de los probióticos en los niveles de triglicéridos (TG) y en el colesterol de lipoproteínas de alta densidad (c-HDL). Los efectos de los probióticos en la disminución de los niveles de CT y c-LDL fueron mayores en los casos donde la intervención duró más tiempo, en ciertas cepas probióticas y en sujetos más jóvenes con hipercolesterolemia leve.

Conclusión

Este metaanálisis reveló que el uso de probióticos puede reducir significativamente los niveles de CT y c-LDL en adultos hipercolesterolémicos, lo que brinda la esperanza de reducir los factores de riesgo relativos al desarrollo de enfermedad cardiovascular.

Palabras clave:
Probióticos
Hipercolesterolemia
Metaanálisis

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