Hermansky-Pudlak syndrome: A case report

Caballero Vázquez, Alberto; Vizcaíno Ricoma, Joaquín; Rogado González, M. Cruz; Romero Ortiz, Ana Dolores

doi:10.1016/j.medcle.2015.05.006

array:24 ["pii" => "S2387020615000480" "issn" => "23870206" "doi" => "10.1016/j.medcle.2015.05.006" "estado" => "S300" "fechaPublicacion" => "2015-02-02" "aid" => "2932" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2013" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2015;144:141-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 214 "formatos" => array:2 [ "HTML" => 133 "PDF" => 81 ] ] "Traduccion" => array:1 [ "es" => array:18 [ "pii" => "S0025775314002218" "issn" => "00257753" "doi" => "10.1016/j.medcli.2014.03.004" "estado" => "S300" "fechaPublicacion" => "2015-02-02" "aid" => "2932" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "subdocumento" => "cor" "cita" => "Med Clin. 2015;144:141-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 586 "formatos" => array:2 [ "HTML" => 448 "PDF" => 138 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "Carta al Editor" "titulo" => "Síndrome de Hermansky-Pudlak: descripción de un caso" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "141" "paginaFinal" => "142" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hermansky-Pudlak syndrome: A case report" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alberto Caballero Vázquez, Joaquín Vizcaíno Ricoma, M. Cruz Rogado González, Ana Dolores Romero Ortiz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Alberto" "apellidos" => "Caballero Vázquez" ] 1 => array:2 [ "nombre" => "Joaquín" "apellidos" => "Vizcaíno Ricoma" ] 2 => array:2 [ "nombre" => "M. Cruz" "apellidos" => "Rogado González" ] 3 => array:2 [ "nombre" => "Ana Dolores" "apellidos" => "Romero Ortiz" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020615000480" "doi" => "10.1016/j.medcle.2015.05.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020615000480?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775314002218?idApp=UINPBA00004N" "url" => "/00257753/0000014400000003/v2_201706012044/S0025775314002218/v2_201706012044/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2387020615000522" "issn" => "23870206" "doi" => "10.1016/j.medcle.2015.05.010" "estado" => "S300" "fechaPublicacion" => "2015-02-02" "aid" => "3094" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2015;144:143" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 117 "formatos" => array:2 [ "HTML" => 100 "PDF" => 17 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Image of the week" "titulo" => "Groove sign and thickened fascia in eosinophilic fasciitis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "143" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Signo del surco y engrosamiento de la fascia en la fascitis eosinofílica" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 602 "Ancho" => 796 "Tamanyo" => 120336 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gonzalo Labarca, Renatta de Grazia, Pamela Turrillas" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Gonzalo" "apellidos" => "Labarca" ] 1 => array:2 [ "nombre" => "Renatta" "apellidos" => "de Grazia" ] 2 => array:2 [ "nombre" => "Pamela" "apellidos" => "Turrillas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775314006307" "doi" => "10.1016/j.medcli.2014.08.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775314006307?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020615000522?idApp=UINPBA00004N" "url" => "/23870206/0000014400000003/v1_201510132016/S2387020615000522/v1_201510132016/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2387020615000571" "issn" => "23870206" "doi" => "10.1016/j.medcle.2014.06.003" "estado" => "S300" "fechaPublicacion" => "2015-02-02" "aid" => "3048" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2015;144:140-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 123 "formatos" => array:2 [ "HTML" => 89 "PDF" => 34 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "Letter to the Editor" "titulo" => "Enteropathy by olmesartan" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "140" "paginaFinal" => "141" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enteropatía por olmesartán" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luis Téllez Villajos, Laura Crespo Pérez, Ana Cano Ruiz, Víctor Moreira Vicente" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Luis" "apellidos" => "Téllez Villajos" ] 1 => array:2 [ "nombre" => "Laura" "apellidos" => "Crespo Pérez" ] 2 => array:2 [ "nombre" => "Ana" "apellidos" => "Cano Ruiz" ] 3 => array:2 [ "nombre" => "Víctor" "apellidos" => "Moreira Vicente" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775314005077" "doi" => "10.1016/j.medcli.2014.06.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775314005077?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020615000571?idApp=UINPBA00004N" "url" => "/23870206/0000014400000003/v1_201510132016/S2387020615000571/v1_201510132016/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Letter to the Editor" "titulo" => "Hermansky-Pudlak syndrome: A case report" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "141" "paginaFinal" => "142" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Alberto Caballero Vázquez, Joaquín Vizcaíno Ricoma, M. Cruz Rogado González, Ana Dolores Romero Ortiz" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Alberto" "apellidos" => "Caballero Vázquez" "email" => array:2 [ 0 => "trainingpolar@yahoo.es" 1 => "albertocaballerovazquez@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Joaquín" "apellidos" => "Vizcaíno Ricoma" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M. Cruz" "apellidos" => "Rogado González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Ana Dolores" "apellidos" => "Romero Ortiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Área Integrada de Medicina, Unidad de Neumología, Hospital de Poniente, El Ejido, Almería, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario Virgen de las Nieves, Granada, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Hermansky-Pudlak: descripción de un caso" ] ] "textoCompleto" => "Hermansky-Pudlak syndrome is a recessive autosomal genetic disease characterised by oculocutaneous albinism, associated with a tendency to haemorrhage due to the absence of platelet granules and lysosomal dysfunction resulting from ceroid material accumulation. Additionally, patients commonly develop interstitial pneumopathy, which is a pulmonary affection. Given that this syndrome is highly uncommon—only some 200 cases have been described—we believe that the presentation of this case is of clinical interest.A 50-year old female patient with oculocutaneous albinism, with no other history of interest, had undergone a uterine fibroid procedure with hysterectomy and adnexectomy. The patient had several drug allergies (metamizole, acetylsalicylic acid, butylscopolamine, dexchlorpheniramine and cefixime). The patient had never smoked and did not consume toxic substances. She had no occupational or environmental exposure to toxic substances. She did not have regular contact with animals; she lives in a rural convent. Her family history revealed that her father died from an unspecified pulmonary disease and she had an albino brother who also died from a respiratory disease that was not studied. As regular medication, she had amitriptyline and benzodiazepines for the treatment of migraines episodes. She had dry cough and moderate effort dyspnoea of one year of progression, occasional night sweats and slight weight loss of about 5-6 kg during this period. The patient had no other related symptoms. Her physical examination was within normal limits. Laboratory test results were within the normal range for biochemical analysis, haemogram, proteinogram, immunoglobulin G, A and M, anti-nuclear antibodies, angiotensin-converting enzyme and coagulation. An arterial blood gas study showed severe hypoxemia, with partial oxygen pressure of 63 mmHg but with no abnormalities in other parameters. The chest X-ray showed a diffuse reticulonodular pattern and the chest CT scan revealed a diffuse interstitial pattern with subpleural predominance in upper lobes and bilateral basal predominance with cylindrical bronchiectasis in lower lobes and fibrosis areas. Respiratory function tests showed a moderate restrictive pattern with a total pulmonary capacity of 58.6% compared to the reference value and a diffusing capacity for carbon monoxide (DLCO) due to a reduced unique breathing technique (48.7%). There were no findings from sputum bacilloscopy and culture (standard, mycobacteria and fungi). A fibrobronchoscopy showed generalised inflammation of the entire bronchial system with negative bronchoalveolar lavage for neoplastic cells and infectious agents. Based on findings from the imaging tests described above, the patient underwent a videothoracoscopy-assisted pulmonary biopsy, which confirmed interstitial fibrosis with abundant type 2 pneumocytes, granulomas and macrophages containing ceroid material, a histopathologic diagnosis, together with the patient's oculocutaneous albinism, compatible with Hermansky-Pudlak syndrome.Hermansky-Pudlak syndrome is a recessive autosomal disease<a class="elsevierStyleCrossRef" href="#bib0030">1</a> characterised by oculocutaneous albinism positive for tyrosinase, a platelet storage defect due to the absence of dense bodies and ceroid pigment accumulation in all body macrophages<a class="elsevierStyleCrossRef" href="#bib0035">2</a>. The syndrome is highly uncommon and only some 200 cases had been described prior to 1985. Ceroid material accumulation may lead to dysfunction in organs such as the lungs, intestine, kidneys or heart. The worst complication of this disease is pulmonary fibrosis, which begins during the thirties or forties, with symptoms of effort dyspnoea and dry cough, and a greater predisposition to developing infectious processes, as well as a greater tendency towards bleeding secondary to platelet dysfunction<a class="elsevierStyleCrossRef" href="#bib0040">3</a>. In respiratory function tests, the disease shows a restrictive pattern with reduced DLCO, characterised by hypoxemia at rest. Radiologically, it is characterised by a ground-glass reticulonodular pattern in its initial stages and, in its final stages, this develops into parenchymatous and peribronchial fibrosis with a honeycomb pattern. Findings from the pulmonary biopsy include diffuse interstitial fibrosis<a class="elsevierStyleCrossRef" href="#bib0045">4</a>, alveolar macrophages containing ceroid material and vacuolated type 2 pneumocytes<a class="elsevierStyleCrossRef" href="#bib0035">2</a>, which is positively dyed in the presence of Schiff periodic acid and exhibits an intense orange-red fluorescence under UV light due to the ceroid material<a class="elsevierStyleCrossRef" href="#bib0050">5</a> and type 2 pneumocytes. Currently, Hermansky-Pudlak syndrome has no aetiological treatment and therapeutic measures are restricted to the symptomatic treatment of clinical manifestations and related complications." "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Caballero Vázquez A, Vizcaíno Ricoma J, Rogado González MC, Romero Ortiz AD. Síndrome de Hermansky-Pudlak: descripción de un caso. Med Clin (Barc). 2015;144:141–142." ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary fibrosis in Hermansky-Pudlak syndrome. A case report and review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.M. Pierson" 1 => "D. Ionescu" 2 => "G. Qing" 3 => "A.M. Yonan" 4 => "K. Parkinson" 5 => "T.C. Colby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000091609" "Revista" => array:6 [ "tituloSerie" => "Respiration" "fecha" => "2006" "volumen" => "73" "paginaInicial" => "382" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16490934" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coagulopathy in critically ill patients: Part 1: Platelet disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W. Todd" 1 => "R. Wheeler" 2 => "A. Wheeler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.08-2534" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2009" "volumen" => "136" "paginaInicial" => "1622" "paginaFinal" => "1630" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19995764" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HPS gene mutations in Hermansky-Pudlak syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.A. Spritz" 1 => "J. Oh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/302257" "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "1999" "volumen" => "64" "paginaInicial" => "658" "paginaFinal" => "659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9973306" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hermansky-Pudlak syndrome with diffuse pulmonary fibrosis: radiologic-pathologic correlation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Shimizu" 1 => "T. Matsumoto" 2 => "G. Miura" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Comput Assist Tomogr" "fecha" => "1998" "volumen" => "22" "paginaInicial" => "249" "paginaFinal" => "251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9530389" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interstitial lung disease: Genetic predisposition and inherited interstitial lung diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Raghu" 1 => "R. Hert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Semin Respir Med" "fecha" => "1993" "volumen" => "14" "paginaInicial" => "323" "paginaFinal" => "332" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000014400000003/v1_201510132016/S2387020615000480/v1_201510132016/en/main.assets" "Apartado" => array:4 [ "identificador" => "43309" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014400000003/v1_201510132016/S2387020615000480/v1_201510132016/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020615000480?idApp=UINPBA00004N"]

ISSN: 2387-0206

Launched in 1943, Medicina Clínica is a fortnightly journal aimed at the promotion of clinical research and practice among internal medicine and other specialists. The key characteristics of Medicina Clínica are the scientific and methodological rigor of its manuscripts, the topicality of its contents, and, especially, its practical focus with highly useful information for clinical practice. Medicina Clínica is predominantly interested in publishing original research manuscripts, which are rigorously selected according to their quality, originality, and interest, and also in continued medical education-oriented manuscripts, which are commissioned by the journal to relevant authors (Editorials, Reviews, and Diagnosis and Treatment). These manuscripts contain updated topics with a major clinical or conceptual relevance in modern medicine. The journal adheres to the standards of academic research publications in all aspects including peer-review and ethical principles. Medicina Clínica is included in the General and Internal Medicine category of Thomson Reuters.

See more Open Access Option

Indexed in:

Current Contents/Clinical Medicine, Journal Citation Reports, SCI-Expanded, Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME, MEDES, PASCAL, SCOPUS, SciVerse ScienceDirect

Subscribe:

Impact factor

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.

© Clarivate Analytics, Journal Citation Reports 2022

Impact factor 2023

2.6

Citescore

CiteScore measures average citations received per document published.

Citescore 2023

3.1

SJR

SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.

SJR 2023

0.371

SNIP

SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.

SNIP 2023

0.511

View more metrics

Journal Information

Previous article | Next article

Vol. 144. Issue 3.

Pages 141-142 (February 2015)

Lee este artículo en Español

Export reference

Download PDF

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)

Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”

Subscribe to

Medicina Clínica (English Edition)

More information

Purchase

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now

Contact

Phone for subscriptions and reporting of errors

From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.

Calls from Spain

932 415 960

Calls from outside Spain

+34 932 415 960

E-mail

atencionalcliente@elsevier.com

Publish in

Medicina Clínica

Tools

Free access articles

Early cortical atrophy in REM sleep behavior...

Med Clin. 2024;163:70-3

Disability degree assessment: A comprehensive approach...

Med Clin. 2024;163:e3-e7

Inappropriate hospitalization: Measurement...

Med Clin. 2024;163:91-7

Medicina Clínica (English Edition) follows the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals

Indexed in:

Follow us:

Subscribe:

Article

Subscribe to our newsletter