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Inicio Medicina Clínica (English Edition) Renal involvement in adults with cystic fibrosis: Study of 89 patients
Journal Information
Vol. 163. Issue 5.
Pages 238-241 (September 2024)
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Vol. 163. Issue 5.
Pages 238-241 (September 2024)
Brief report
Renal involvement in adults with cystic fibrosis: Study of 89 patients
Afectación renal en adultos con fibrosis quística: estudio de 89 pacientes
Ester Zamarróna,
Corresponding author
Ester.zamarron@gmail.com

Corresponding author.
, Layla Diabb, Jaime Pavóna, Carlos Carpioa, Rodolfo Álvarez-Salaa, María Concepción Pradosa
a Servicio de Neumología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain
b Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain
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Tables (2)
Table 1. Baseline characteristics.
Table 2. Variables associated with glomerular filtration rate values below 90 ml/min/1.73 m2.
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Abstract
Introduction

We are assisting to an increase in survival rates among individuals with cystic fibrosis (CF). Until now, renal involvement was a minority issue, but with the rise in life expectancy, we will likely see an increase in its prevalence. Our main objective was to assess renal function in CF and study risk factors associated with its deterioration.

Methods

A cross-sectional, retrospective study was conducted, including adults with CF. Clinical, respiratory function, microbiological, blood and urine analysis, and major chronic treatments received were collected.

Results

Eighty nine patients with a mean age of 35 ± 12 years were analyzed. Mean serum creatinine levels were 0.8 ± 0.2 mg/dL. 10.6% had a glomerular filtration rate less than 90 ml/min/1.73 m2. No patient showed albuminuria. In multivariate model, only age was an independent risk factor for reduced glomerular filtration (OR 0.344, 95% CI 0.004−0.017, p = 0.002).

Conclusions

11% of CF adults show decreased glomerular filtration, with age being the sole independent risk factor. Vigilance for this uncommon condition is crucial.

Keywords:
Cystic fibrosis
Renal
Kidney
Life expectancy
Resumen
Introducción

Estamos asistiendo a un progresivo incremento de la supervivencia en la fibrosis quística (FQ). Hasta ahora, la afectación renal era minoritaria, pero con la mejoría de la esperanza de vida, probablemente veremos un aumento de su prevalencia. Nuestro objetivo principal fue evaluar la función renal en FQ y estudiar factores de riesgo asociados a su deterioro.

Métodos

Estudio transversal, retrospectivo en el que se incluyeron adultos con FQ. Se recogieron las características clínicas, de función respiratoria, microbiológicas, análisis de sangre y orina y principales tratamientos crónicos recibidos.

Resultados

Ochenta y nueve pacientes con una edad media de 35 ± 12 años. Los niveles medios de creatinina sérica fueron de 0,8 ± 0,2 mg/dl. El 10,6% tenían un filtrado glomerular menor a 90 ml/min/1,73 m2. Ningún paciente mostró albuminuria. Solo la edad fue factor de riesgo independiente para un filtrado glomerular reducido (OR 0,344, IC95% 0,004–0,017, p = 0,002).

Conclusiones

El 11% de adultos con FQ tienen disminución del filtrado glomerular y la edad es el único factor de riesgo asociado independientemente. Es importante estar alerta de esta entidad hasta ahora poco frecuente.

Palabras clave:
Fibrosis quística
Renal
Riñón
Supervivencia

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