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"documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;156:254-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Reply" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "254" "paginaFinal" => "255" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Respuesta" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Patricia Richi, Martina Steiner, Santiago Muñoz-Fernández" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Patricia" "apellidos" => "Richi" ] 1 => array:2 [ "nombre" => "Martina" "apellidos" => "Steiner" ] 2 => array:2 [ "nombre" => "Santiago" "apellidos" => "Muñoz-Fernández" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775320301603" "doi" => "10.1016/j.medcli.2020.03.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320301603?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020620304034?idApp=UINPBA00004N" "url" => "/23870206/0000015600000005/v1_202103120836/S2387020620304034/v1_202103120836/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2387020621000590" "issn" => "23870206" "doi" => "10.1016/j.medcle.2020.11.008" "estado" => "S300" "fechaPublicacion" => "2021-03-12" "aid" => "5492" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;156:253-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>" "titulo" => "SARS-CoV-2 infection triggering a giant cell arteritis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "253" "paginaFinal" => "254" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Infección por SARS-CoV-2 como desencadenante de una arteritis de células gigantes" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Núria Riera-Martí, Jorge Romaní, Joan Calvet" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Núria" "apellidos" => "Riera-Martí" ] 1 => array:2 [ "nombre" => "Jorge" "apellidos" => "Romaní" ] 2 => array:2 [ "nombre" => "Joan" "apellidos" => "Calvet" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0025775320308216" "doi" => "10.1016/j.medcli.2020.11.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320308216?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621000590?idApp=UINPBA00004N" "url" => "/23870206/0000015600000005/v1_202103120836/S2387020621000590/v1_202103120836/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Influenza vaccine in patients on biologic therapy; also with belimumab" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "254" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Luis Callejas Rubio, Carmen Valero Ubierna, Norberto Ortego Centeno" "autores" => array:3 [ 0 => array:4 [ "nombre" => "José Luis" "apellidos" => "Callejas Rubio" "email" => array:1 [ 0 => "jlcalleja@telefonica.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Carmen" "apellidos" => "Valero Ubierna" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Norberto" "apellidos" => "Ortego Centeno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Enfermedades Sistémicas, Servicio de Medicina Interna, Hospital San Cecilio de Granada, Granada, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Preventiva, Hospital San Cecilio de Granada, Granada, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vacuna de la gripe en pacientes tratados con fármacos biológicos; también con belimumab" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We have read with interest the article recently published in your journal by Richi et al. on influenza vaccine response in patients receiving biologic therapies<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>. Multiple biologics were included in the study, but we have missed belimumab, a biologic agent approved for the treatment of systemic lupus erythematosus (SLE)<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The pivotal study of belimumab in SLE, BLISS-76, which included patients treated with placebo or monthly intravenous belimumab for 76 weeks, assessed a group of patients who had received different vaccinations, including the influenza vaccine. Antibodies were determined at baseline and at 52 weeks, and the percentage of change in the levels and the proportion of patients who maintained the levels were assessed. No significant changes were observed in the antigens of the vaccine received in 2007–8, nor in the percentage that maintained titers. In patients who received influenza vaccination, overall, the titers increased significantly, although it was higher in patients with placebo than those treated, although in some strains, namely Brisbane 10 and 59, the percentage of patients with titres >1:10 was lower in treated patients<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>. The authors conclude that belimumab treatment does not affect pre-existing antibodies in response to influenza vaccination in SLE patients, and that there does not appear to be an increased risk of inadequate response to vaccination during belimumab treatment.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The current recommendations with the available results are in favour of influenza vaccination of patients with SLE under treatment with belimumab<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>. We vaccinate all our treated patients in our routine practice.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Callejas Rubio JL, Valero Ubierna C, Ortego Centeno N. Vacuna de la gripe en pacientes tratados con fármacos biológicos; también con belimumab. Med Clin (Barc). 2021;156:254.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibody responses to influenza vaccine in patients on biological therapy: results of RIER cohort study [Article in English, Spanish]" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Richi" 1 => "M.D. Martín" 2 => "M.T. Navío" 3 => "L. González-Hombrado" 4 => "M. Salido" 5 => "J. Llorente" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.medcli.2019.02.003" "Revista" => array:6 [ "tituloSerie" => "Med Clin (Barc)." "fecha" => "2019" "volumen" => "153" "paginaInicial" => "380" "paginaFinal" => "386" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31060878" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Belimumab in the treatment of systemic lupus erythematous: an evidence based review of its place in therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Marcondes" 1 => "M. Scheinberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.autrev.2017.11.013" "Revista" => array:6 [ "tituloSerie" => "Autoimmun Rev." 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"fecha" => "2012" "volumen" => "39" "paginaInicial" => "1632" "paginaFinal" => "1640" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22707609" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations and barriers to vaccination in systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Garg" 1 => "N. Mufti" 2 => "T.N. Palmore" 3 => "S.A. Hasni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.autrev.2018.04.006" "Revista" => array:6 [ "tituloSerie" => "Autoimmun Rev." "fecha" => "2018" "volumen" => "17" "paginaInicial" => "990" "paginaFinal" => "1001" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30103044" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015600000005/v1_202103120836/S2387020621000474/v1_202103120836/en/main.assets" "Apartado" => array:4 [ "identificador" => "43309" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015600000005/v1_202103120836/S2387020621000474/v1_202103120836/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621000474?idApp=UINPBA00004N" ]
