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"documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2016;146:334" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1 "PDF" => 1 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in medicine</span>" "titulo" => "Cranial lytic lesions" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "334" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lesiones líticas craneales" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 750 "Ancho" => 726 "Tamanyo" => 92996 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Ángel Santos Sánchez, Almudena Blázquez Sáez, Luís R. Ramos Pascua, M. Antonia Rebollo Alvarado" "autores" => array:4 [ 0 => array:2 [ "nombre" => "José Ángel" "apellidos" => "Santos Sánchez" ] 1 => array:2 [ "nombre" => "Almudena" "apellidos" => "Blázquez Sáez" ] 2 => array:2 [ "nombre" => "Luís R." "apellidos" => "Ramos Pascua" ] 3 => array:2 [ "nombre" => "M. Antonia" "apellidos" => "Rebollo Alvarado" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775315004558" "doi" => "10.1016/j.medcli.2015.07.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315004558?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S238702061630256X?idApp=UINPBA00004N" "url" => "/23870206/0000014600000007/v1_201607151011/S238702061630256X/v1_201607151011/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in medicine</span>" "titulo" => "Methamizole-induced agranulocytosis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e41" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "David Pedrazas López, Bernat de Pablo Márquez, David García Font, Eva Sánchez García" "autores" => array:4 [ 0 => array:3 [ "nombre" => "David" "apellidos" => "Pedrazas López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Bernat" "apellidos" => "de Pablo Márquez" "email" => array:1 [ 0 => "bernatdepablo@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "David" "apellidos" => "García Font" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Eva" "apellidos" => "Sánchez García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Urgencias, Equipo de Atención Primaria Abrera, Abrera, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urgencias, Hospital Universitari Mútua Terrassa, Terrasa, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Interna, Fundació Hospital Sant Joan de Déu de Martorell, Martorell, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Agranulocitosis secundaria a tratamiento con metamizol" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 671 "Ancho" => 1500 "Tamanyo" => 250753 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 38-year-old patient diagnosed with agranulocytosis caused by methimazole, following fever after being treated with that medication. Laboratory tests showed neutropenia and peripheral blood smear (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) showing agranulocytosis (one white blood cell in smear) without any other blood dyscrasias. Methimazole treatment was suspended, empiric coverage was initiated with broad-spectrum antibiotic treatment (amikacin and piperacillin<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>tazobactam) and colony stimulating factors were administered. Agranulocytosis by methimazole is a type B side effect (independent of the effect of the medication), that is potentially serious (close to 10% mortality) and with an estimated incident rate on the population of between 7.3 and 9.3 cases per million per year.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Pedrazas López D, de Pablo Márquez B, García Font D, Sánchez García E. Agranulocitosis secundaria a tratamiento con metamizol. Med Clin (Barc). 2016;146:e41.</p>" ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 671 "Ancho" => 1500 "Tamanyo" => 250753 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000014600000007/v1_201607151011/S2387020616302558/v1_201607151011/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014600000007/v1_201607151011/S2387020616302558/v1_201607151011/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616302558?idApp=UINPBA00004N" ]
