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Vol. 25. Issue S1.
Catástrofes neurológicas
Pages 61-67 (October 2010)
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Vol. 25. Issue S1.
Catástrofes neurológicas
Pages 61-67 (October 2010)
Catástrofes Neurológicas
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Catástrofes derivadas de las técnicas complementarias de diagnóstico neurológico
Catastrophes caused by neurologic diagnostic procedures
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5903
M. Arias Gómez
Servicio de Neurología, Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España
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Resumen

Las complicaciones graves (catástrofes) de las numerosas técnicas diagnósticas neurológicas pueden producirse tanto por indicación y omisión como por retraso, ejecución o interpretación erróneas. La cefalea por hipotensión del LCR es la complicación más frecuente de la punción lumbar; si es intensa, puede tratarse con parche hemático. Las herniaciones cerebrales son la complicación más grave; para evitarlas, siempre hay que realizar antes un estudio de TC o RM: el hallazgo de una lesión con evidente efecto masa contraindica la punción. La no indicación de punción lumbar ante una cefalea centinela puede pasar por alto una hemorragia subaracnoidea menor, que se transformará en catástrofe en caso de recidiva. La prueba del edrofonio (tensilón) puede complicarse con bradicardia y/o asistolia. Su omisión puede dar lugar a que no se diagnostiquen precozmente cuadros de miastenia grave, sobre todo en sujetos de edad avanzada. La electromiografía tiene escasas complicaciones (casos puntuales de hematomas paraespinales y neumotórax). Los ultrasonidos, la angio-TC y la angio-RM han reducido las indicaciones de angiografía cerebral, cuyas complicaciones principales, además de reacciones al contraste, sangrado e infecciones en el lugar de la inyección, son los déficits neurológicos por disección vascular o embolismo de material ateromatoso. En la evaluación prequirúrgica de la epilepsia se realizan determinadas técnicas como vídeo-EEG con supresión de la medicación, lo que puede precipitar la aparición de crisis repetidas con riesgo de lesiones y estatus epiléptico. Los registros mediante electrodos invasivos y las mantas de electrodos pueden complicarse con infecciones y hemorragia intracraneal. La biopsia cerebral se indica ante la sospecha de patología tratable, pero con potenciales efectos secundarios graves de los tratamientos (radioterapia, quimioterapia). Puede agravar déficits neurológicos previos o producir otros nuevos. Las pruebas genéticas no están indicadas en niños sanos en los que se sospeche una entidad sin tratamiento. En los adultos se realizan en casos seleccionados, previa información detallada, y teniendo en cuenta posibles reacciones emocionales graves.

Palabras clave:
Complicaciones neurológicas
Punción lumbar Edrofonio
EMG
Angiografía
Vídeo-EEG
Biopsia cerebral
Pruebas genéticas
Abstract

Serious complications (catastrophes) resulting from diverse neurological diagnostic procedures can be caused by erroneous indication and omission, as well as by delay and erroneous execution or interpretation. Headache, caused by cerebrospinal fluid (CSF) hypotension, is a frequent complication of lumbar puncture; hematic patch is a therapeutic option for severe cases. The most serious complication is cerebral herniation and, for its prevention, computed tomography (CT) or cerebral magnetic resonance imaging (MRI) must always be performed before lumbar puncture: a lesion with evident mass effect is a contraindication. Some cases of minor subarachnoid hemorrhages can produce sentinel headache: when the findings of CT scans are normal, lumbar puncture must be performed for diagnosis and prevention of a catastrophic recurrence. Edrophonium testing can be complicated with bradycardia and/or asystole. The lack of indication of this procedure is a cause of under-diagnosis of myasthenia gravis, especially in older people. Electromyography produces few complications (rare cases of paraspinal hematomas and pneumothorax). Ultrasound, CT angiography and MR angiography examinations have decreased the indications for cerebral angiography, whose main complications —in addition to contrast reactions, hemorrhage and infection at the injection site— are neurological deficits caused by vascular dissection or atheromatous embolus. Video-electroencephalogram (EEG) recording with medication suppression can be used in the presurgical evaluation of epilepsy, which can precipitate repeated seizures with the risk of injuries and status epilepticus. The possible complications of studies performed with invasive electrodes are infections and intracranial hemorrhages. Cerebral biopsy is indicated when treatable disease is suspected but the therapeutic options (radiotherapy, chemotherapy) have potential serious adverse effects. Furthermore, cerebral biopsy can aggravate previous neurological deficits or produce new deficits. Genetic testing is not indicated in healthy children when an untreatable disease is suspected. In adults, genetic testing is appropriate in selected cases, but detailed previous information should be gathered and the possibility of triggering serious emotional reactions should always be considered.

Key words:
Neurologic complications
Lumbar puncture
Edrophonium
EMG
Angiography
Video-EEG
Cerebral biopsy
Genetic testing
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Bibliografía
[1.]
A.I. Faden.
Iatrogenic illness. An overview with particular reference to neurologic complications.
Neurol Clin., 16 (1998), pp. 1-8
[2.]
M.S. Ellenby, K. Tegteyer, S. Lai, D.A.V. Braner.
Lumbar puncture.
N Engl J Med., 355 (2006), pp. 12
[3.]
R.W. Evans.
Complications of the lumbar puncture.
Neurol Clin., 16 (1998), pp. 83-105
[4.]
A.P. Sempere, L. Berenguer-Ruíz, M. Lezcano-Rodas, F. Mira-Berenguer, M. Waez.
Punción lumbar: indicaciones, contraindicaciones, complicaciones y técnica de realización.
Rev Neurol., 45 (2007), pp. 433-436
[5.]
K.M. Kuntz, E. Kokmen, J.C. Stevens, P. Miller, K.P. Offord, M.M. Ho.
Post-lumbar puncture headaches: experience in 501 consecutive procedures.
Neurology., 42 (1992), pp. 1884-1887
[6.]
C. Armon, R.W. Evans.
Prevention of post-lumbar puncture headaches: report of the Therapeutic and Technology Assessment Subcommittee of the American Academy of Neurology.
[7.]
S. Wiesel, M.J. Tessler, L.J. Easdwn.
Postdural puncture headache: a randomized prospective comparison of the 24 gauge Sprotte and the 27 gauge Quincke needles in young patients.
Can J Anaesth., 40 (1993), pp. 607-611
[8.]
F. Van Kooten, R. Oedit, S.L.M. Bakker, D.W.J. Dippel.
Epidural blood patch in post dural puncture headache: a randomized, observer-blind, controlled clinical trial.
J Neurol Neurosurg Psychiatry., 79 (2008), pp. 553-558
[9.]
J.V. McDonald, T.E. Klump.
Intraspinal epidermoid tumours caused by lumbar puncture.
Arch Neurol., 43 (1986), pp. 936-939
[10.]
J. Korein, H. Cravioto, M. Leiach.
Reevaluation of lumbar puncture: a study of 129 patients with papilledema or intracranial hypertension.
Neurology., 9 (1959), pp. 290-297
[11.]
H.C. Sullivan.
Fatal tonsilar herniation in pseudotumor cerebri.
Neurology., 41 (1991), pp. 1142-1144
[12.]
M.M. Mordecai, S.J. Brull.
Spinal anestesia.
Curr Opin Anaesthesiol., 18 (2005), pp. 527-533
[13.]
V. Moen, N. Dahlgren, L. Irestedt.
Severe neurologic complications after central neuraxial blockades in Sweden 1990–1999.
Anaesthesiology., 101 (2004), pp. 950-959
[14.]
J.I. Suarez, R.W. Tarr, W.R. Selman.
Aneurysmal subarachnoid hemorrhage.
N Engl J Med., 354 (2006), pp. 387-396
[15.]
L. Gould, M. Zahir, R.F. Gomprecht.
Cardiac arrest during edrophonium administration.
Am Heart J., 81 (1971), pp. 437-438
[16.]
R.M. Rossen, J. Krikorian, E.W. Hancock.
Ventricular asystole after edrophonium choride administration.
JAMA., 235 (1976), pp. 1041-1042
[17.]
E.B. Ing, S.Y. Ing, T. Ing, J.A. Ramocki.
The complication rate of edrophonium testing for suspected myasthenia gravis.
Can J Ophtalmol., 35 (2000), pp. 141-144
[18.]
G. Kleiner-Fisman, H.S. Kott.
Myasthenia gravis mimicking stroke in elderly patients.
Mayo Clin Proc., 73 (1998), pp. 1077
[19.]
A. Vincent, L. Clover, C. Buckley, J.G. Evans.
Rothwell and the UK Myastenia Gravis Survey. Evidence of underdiagnosis of myasthenia gravis in older people.
J Neurol Neurosurg Psychiatry., 74 (2003), pp. 1105-1108
[20.]
J.B. Caress, S.B. Rutkove, M. Carlin, S. Khoshbin, D.C. Preston.
Paraspinal muscle hematoma after electromyography.
Neurology., 47 (1996), pp. 269-272
[21.]
Y. Baba, K. Hentschel, D. Freeman, D.F. Broderick, Z.K. Wszolek.
Large paraspinal and illiopsoas muscle hematomas.
Arch Neurol., 62 (2005), pp. 1306
[22.]
J.S. Sandhu, A.K. Wakhloo.
Neuroimaging: neuroangiographic anatomy and common cerebrovacular diseases.
Neurology in clinical practice, pp. 625-643
[23.]
T.J. Kaufmann, J. Huston III, J.N. Mandrekar, C.D. Schieck, K.R. Thielen, D.F. Kallmes.
Complications of diagnostic cerebral angiography: evaluation of 19826 consecutive patients.
Radiology., 243 (2007), pp. 813-819
[24.]
A.A. Dawkins, A.L. Evans, J. Wattam, C.A.J. Romanowski, D.J.A. Connoly, T.J. Hodgson, et al.
Complications of cerebral angiography: a prospective analysis of 2924 consecutive procedures.
Neuroradiology., 49 (2007), pp. 753-759
[25.]
A. Kunz, G. Hahn, D. Mucha, A. Müller, A. Barrett, R. Von Kummer, et al.
Echo-enhanced transcranial color-coded duplex sonography in the diagnosis of cerebrovascular events: a validation study.
Am J Neuroradiology., 27 (2006), pp. 2122-2127
[26.]
M.D. Hill, A.M. Demchuck, R. Frayne.
Noinvasive imaging is improving but digital subtraction angiography remains the gold standard.
Neurology., 68 (2007), pp. 2057-2058
[27.]
A.I. Qureshi, V. Janardhan, R.A. Hanel, G. Lareina.
Comparison of endovasacular and surgical treatments for intracranial aneurysms: an evidence-based review.
Lancet Neurol., 6 (2007), pp. 816-825
[28.]
B.N. Mclean, S. Wimalaratna.
Sudden death in epilepsy recorded in ambulatory EEG.
J Neurol Neurosurg Psychiatry., 78 (2007), pp. 1395-1397
[29.]
I. Nashef, S. Garner, J.W.A.S. Sander, D.R. Fish, S.D. Shorvon.
Circumstances of death in sudden death in epilepsy: interviews of bereaved relatives.
J Neurol Neurosurg Psychiatry., 64 (1998), pp. 340-352
[30.]
R. Kloster, T. Engleskjen.
Sudden unexpected death in epilepsy (SUDED): a clinical perspective and a search for risk factors.
J Neurol Neurosurg Psychiatry., 67 (1999), pp. 436-444
[31.]
N.K. So, M.R. Sperling.
Ictal asystole and SUDEP.
[32.]
L. Nashef, F. Walker, P. Allen, J.W. Sander, S.D. Shorvon, D.R. Fish.
Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy.
J Neurol Neurosurg Psychiatry., 60 (1996), pp. 297-300
[33.]
A.B. Rose, P.H. McCabe, F.G. Gilliam, B.J. Smith, J.G. Boggs, J.L. Ficker, et al.
Occurrence of seizures clusters and status epilepticus during inpatient video-EEG.
Neurology., 60 (2003), pp. 975-978
[34.]
E.S. Feen, E.M. Bershad, J.I. Suárez.
Status epilepticus.
South Med J., 101 (2008), pp. 400-406
[35.]
B.A. Malow, T.A. Blaxton, B. Stertz, W.H. Theodore.
Carbamazepine withdrawal: effects of taper rate on seizure frequency.
Neurology., 43 (1993), pp. 2280-2284
[36.]
C. Onal, H. Otsubo, T. Araki, S. Chitoku, A. Ochi, S. Weiss, et al.
Complications of invasive subdural grid monitoring in children with epilepsy.
J Neurosurg., 98 (2003), pp. 1017-1026
[37.]
J.M. Johnston Jr., F.T. Mangano, J.G. Ojemann, T.S. Park, E. Trevathan, M.D. Smyth.
Complications of invasive subdural electrode monitoring at St. Louis Children's Hospital, 1994–2005.
J Neurosurg., 105 (2006), pp. 343-347
[38.]
J.C. Martín-Berra, L.C. Álvaro, I. Aranzábal, M.M. Freijo, B. Huete, C. Cortina.
Biopsias cerebrales no tumorales: análisis de 50 casos.
Rev Neurol., 34 (2002), pp. 306-309
[39.]
M.L. Apuzzo, P.T. Chandrasoma, D. Cohen, C.S. Zee, V. Zelman.
Computed imaging stereotaxy experience and perspective related to 500 procedures applied to brain masses.
Neurosurgery., 20 (1987), pp. 930-937
[40.]
D.G. Thomas, R.M. Nouby.
Experience with 300 cases of CT directed stereotactic surgery for lesion biopsy and aspiration of hematoma.
Br J Neurosurg., 3 (1989), pp. 321-325
[41.]
R.J. Cook, B.L. Guthrie.
Complications of stereotactic biopsy.
Perspect Neurol Surg., 4 (1993), pp. 131
[42.]
W. Burke.
Genetic testing.
N Engl J Med., 347 (2002), pp. 1867-1875
[43.]
E. McPherson.
Clinical diagnosis and testing in clinical practice.
Clin Med Res., 2 (2006), pp. 123-129
Copyright © 2010. Sociedad Española de Neurología
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