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Inicio Psiquiatría Biológica Clozapine delay results in poorer outcomes for treatment-resistant schizophrenia...
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Vol. 31. Issue 4.
(October - December 2024)
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Vol. 31. Issue 4.
(October - December 2024)
Review Article
Clozapine delay results in poorer outcomes for treatment-resistant schizophrenia patients
El retraso en la clozapina produce peores resultados en los pacientes con esquizofrenia resistentes al tratamiento
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Kalyani Rajalingham
Corresponding author
kalyani.rajalingham@mail.mcgill.ca

Corresponding author at: 8518 Stuart Ave., Montreal, Quebec H3N 2S5, Canada.
Concordia University, Department of Biology, 7141 Sherbrooke St W, Montreal, Quebec H4B 1R6, Canada
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Abstract

Treatment-resistant schizophrenia (TRS) is a condition where schizophrenia patients do not respond to at least 2 non-clozapine anti-psychotics administered in proper dosage and for a proper period of time. The typical treatment for TRS is clozapine but many alternatives are attempted prior to administering clozapine. Current research shows that the effectiveness of treatment with clozapine decreases with time in TRS patients; the longer a TRS patient waits to use clozapine, the less effective it is likely to be. In this paper, I review clozapine delay; clozapine treatment is effective if it happens within the first 3 years.

Keywords:
Treatment-resistant schizophrenia
Clozapine
Ultra-treatment-resistant schizophrenia
Resumen

La esquizofrenia resistente al tratamiento (TRS) es una afección en la que los pacientes con esquizofrenia no responden a al menos dos antipsicóticos distintos de la clozapina administrados en la dosis adecuada y durante un período de tiempo adecuado. El tratamiento típico para TRS es la clozapina, pero se intentan muchas alternativas antes de administrar clozapina. Las investigaciones actuales muestran que la eficacia del tratamiento con clozapina disminuye con el tiempo en pacientes con TRS; cuanto más espere un paciente con TRS para usar clozapina, menos efectiva será. En este artículo, reviso el retraso de la clozapina; El tratamiento con clozapina es eficaz si se realiza dentro de los primeros 3 años.

Palabras clave:
Esquizofrenia resistente al tratamiento
clozapina
esquizofrenia ultrarresistente al tratamiento

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