Share
array:24 [ "pii" => "S2173510724000454" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2024.03.003" "estado" => "S300" "fechaPublicacion" => "2024-03-01" "aid" => "1483" "copyright" => "SERAM" "copyrightAnyo" => "2023" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2024;66:166-80" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0033833823000590" "issn" => "00338338" "doi" => "10.1016/j.rx.2023.04.002" "estado" => "S300" "fechaPublicacion" => "2024-03-01" "aid" => "1483" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2024;66:166-80" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Actualización</span>" "titulo" => "Los retos en la evaluación radiológica de las metástasis cerebrales, más allá de la progresión" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:3 [ 0 => "es" 1 => "es" 2 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "166" "paginaFinal" => "180" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Challenges in radiological evaluation of brain metastases, beyond progression" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2855 "Ancho" => 3008 "Tamanyo" => 682341 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Esquema que representa el efecto <span class="elsevierStyleItalic">bystander</span> (A), donde observamos una respuesta de las células metastásicas (representadas en azul claro) al irradiar células vecinas (representadas en azul). Imagen de TC de cráneo mostrando la planificación del tratamiento con radioterapia (B y C). Imágenes 3DT1 con contraste antes del tratamiento con radioterapia fraccionada (D) y 2 meses después de éste (E), donde se aprecia una respuesta de las metástasis cerebrales radiadas (flechas) pero también de la lesión talámica derecha (círculo), no incluida en el campo de irradiación de ninguna de las lesiones, y en ausencia de otro tratamiento dirigido. Nótese la aparición de una nueva metástasis frontal izquierda (E) (cabeza de flecha).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Ortiz de Mendivil, P. Martín-Medina, L. García-Cañamaque, B. Jiménez-Munarriz, R. Ciérvide, J. Diamantopoulos" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Ortiz de Mendivil" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Martín-Medina" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "García-Cañamaque" ] 3 => array:2 [ "nombre" => "B." "apellidos" => "Jiménez-Munarriz" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Ciérvide" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Diamantopoulos" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0005" class="elsevierStylePara elsevierViewall">Las metástasis cerebrales se tratan con cirugía, radioterapia o terapia sistémica.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0010" class="elsevierStylePara elsevierViewall">Los criterios RANO-BM se han de aplicar con cautela tras radioterapia e inmunoterapia.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0015" class="elsevierStylePara elsevierViewall">La pseudoprogresión es un crecimiento transitorio debido a cambios inflamatorios.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">•</span><p id="par0020" class="elsevierStylePara elsevierViewall">El signo de la «nube inflamatoria» se ha relacionado con la pseudoprogresión.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">•</span><p id="par0025" class="elsevierStylePara elsevierViewall">El signo del «realce en anillo incompleto» puede encontrarse en las radionecrosis.</p></li></ul></p></span>" ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173510724000454" "doi" => "10.1016/j.rxeng.2024.03.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510724000454?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833823000590?idApp=UINPBA00004N" "url" => "/00338338/0000006600000002/v1_202403120553/S0033833823000590/v1_202403120553/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173510724000417" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2023.06.006" "estado" => "S300" "fechaPublicacion" => "2024-03-01" "aid" => "1521" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2024;66:181-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Radiology today</span>" "titulo" => "Paediatric interventional radiology: it’s not child’s play" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "181" "paginaFinal" => "185" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Radiologia intervencionista en pediatría: no es un juego de ninos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Alonso Sánchez, D.A. Parra, C. Parra-Fariñas" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Alonso Sánchez" ] 1 => array:2 [ "nombre" => "D.A." "apellidos" => "Parra" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Parra-Fariñas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0033833823001509" "doi" => "10.1016/j.rx.2023.06.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833823001509?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510724000417?idApp=UINPBA00004N" "url" => "/21735107/0000006600000002/v1_202404120611/S2173510724000417/v1_202404120611/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173510724000399" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2023.05.007" "estado" => "S300" "fechaPublicacion" => "2024-03-01" "aid" => "1500" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2024;66:155-65" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Radiology through images</span>" "titulo" => "Checklist: Neck computed tomography in non-traumatic emergencies" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "155" "paginaFinal" => "165" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lista de verificación: tomografía computarizada de cuello en urgencias no traumáticas" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1149 "Ancho" => 1591 "Tamanyo" => 86811 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Cervical cellulitis, superficial fasciitis and myositis.</span> A 50-year-old male with tumour and neck pain, with no history of trauma. There is a marked enlargement of the left sternocleidomastoid muscle <span class="elsevierStyleItalic">(asterisk),</span> with trabeculation of the adjacent fat and thickening of the superficial cervical fascia and <span class="elsevierStyleItalic">platysma (arrow).</span></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Martínez-Checa Guiote, C. Utrilla Contreras, P. García Raya, S. Ossaba Vélez, M. Martí de Gracia, G. Garzón Moll" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Martínez-Checa Guiote" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Utrilla Contreras" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "García Raya" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Ossaba Vélez" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Martí de Gracia" ] 5 => array:2 [ "nombre" => "G." "apellidos" => "Garzón Moll" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0033833823000966" "doi" => "10.1016/j.rx.2023.05.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833823000966?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510724000399?idApp=UINPBA00004N" "url" => "/21735107/0000006600000002/v1_202404120611/S2173510724000399/v1_202404120611/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Update in Radiology</span>" "titulo" => "Challenges in radiological evaluation of brain metastases, beyond progression" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "166" "paginaFinal" => "180" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Ortiz de Mendivil, P. Martín-Medina, L. García-Cañamaque, B. Jiménez-Munarriz, R. Ciérvide, J. Diamantopoulos" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Ortiz de Mendivil" "email" => array:1 [ 0 => "aomendivil@hmhospitales.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "P." "apellidos" => "Martín-Medina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "L." "apellidos" => "García-Cañamaque" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "B." "apellidos" => "Jiménez-Munarriz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "R." "apellidos" => "Ciérvide" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "J." "apellidos" => "Diamantopoulos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Radiodiagnóstico, Sección de Neurorradiología, Hospital Universitario HM Sanchinarro, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Nuclear, HM Hospitales, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Oncología Médica, Hospital Universitario HM Sanchinarro, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Oncología Radioterápica, Hospital Universitario HM Sanchinarro, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Neurocirugía, HM Hospitales, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Los retos en la evaluación radiológica de las metástasis cerebrales, más allá de la progresión" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 2437 "Ancho" => 2175 "Tamanyo" => 277600 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Partial response associated to the ‘inflammatory cloud’ sign. Case 1: Lung cancer patient. Contrast-enhanced 3D T1-weighted cross-sectional images: pre-treatment (A), and at three months after radiotherapy treatment (B), which show a reduction in the size of the tumour tissue (arrowhead) at the same time that there is a diffuse focal enhancement similar to a ‘cloud’ (arrows in B). Case 2: Breast cancer patient. Contrast-enhanced 3D T1-weighted cross-sectional images at six months after treatment (C), which show the ‘inflammatory cloud’ sign (arrows). Image D shows a partial response in the cluster of LM metastases (arrowheads).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Brain metastases are the most common intracranial tumours among adults and are associated with poor survival. They are found in 15%–40% of cancer patients.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The distribution of brain metastases depends on blood flow, and they usually reach the brain through the arteries. Consequently, they are mostly located in the middle cerebral artery territory, in distal vascular regions and areas where there is an arterial calibre change, such as the grey-white matter junction.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> A venous spread of metastatic disease is typical of pelvic (prostate and uterine) and gastrointestinal primary tumours. It spreads via the Batson venous plexus to the inferior petrosal sinus.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This explains the predisposition to infratentorial involvement.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The first-choice imaging test for the evaluation of brain metastases is MRI.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> CT scans are requested in emergency situations to assess patients with neurological deficits.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Metastases are not usually haemorrhagic, although choriocarcinomas, melanomas, and metastases originating in the thyroid or kidney are more frequently associated with haemorrhage. Lung and breast metastases bleed only occasionally; however, they are responsible for the majority of metastatic haemorrhages since they are the most prevalent primary tumours.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Metastases can be parenchymal or extra-axial.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Leptomeningeal (LM) involvement occurs through the haematogenous spread of malignant cells, whereas meningeal carcinomatosis or meningeal seeding, typical of breast or lung tumours, spreads via the cerebrospinal fluid (CSF). The downward flow of the cancer cells explains the tumour predisposition for the posterior fossa. Some authors do not differentiate between the two situations.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> However, survival in the first scenario can extend to years in patients who respond well to radiotherapy (RT) treatment, or in patients treated with targeted therapies called tyrosine kinase inhibitors (TKIs) for mutations in receptors such as the epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. Conversely, prognosis for carcinomatosis is poor.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The aim of this article is to summarise the radiological features of brain metastases. Growth after RT should not always be interpreted as tumour recurrence, as it may be related to inflammatory phenomena. It is important to differentiate tumour growth from inflammation in order to avoid unnecessary surgery or repeat radiation. This article describes the characteristics of these inflammatory phenomena and highlights two radiological signs, the ‘inflammatory cloud’ and the ‘incomplete ring enhancement’, which have been associated with pseudoprogression and radiation necrosis.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Treatment of brain metastases</span><p id="par0035" class="elsevierStylePara elsevierViewall">Radiologists must be familiar with treatments for brain metastases in order to adequately assess response. Treatment can be local via RT or surgery, or even systemic, in cases where certain mutations allow for targeted therapy.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> According to the European Society for Medical Oncology, the choice depends on the location, size and number of lesions, as well as the status of the extracranial disease, the general condition of the patient and the histological type, given that melanoma and renal cancer are, by way of example, more resistant to radiation.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,10</span></a> Surgery is usually the first-line treatment for patients with unknown histology, good general health, and a single, accessible lesion or metastasis with a mass effect that causes significant symptoms. Radiosurgery can be considered for patients with one to multiple metastases, administered in a single session to lesions with a diameter <3 cm and fractionated when the volume is greater.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Whole brain radiotherapy approaches are only used on patients with multiple metastases and for palliative purposes, in contrast with intracranial stereotactic radiosurgery (SRS), which is more radical.</p><p id="par0045" class="elsevierStylePara elsevierViewall">SRS is a non-invasive technique based on a system that converges radiation beams to deliver a high dose of radiation with great precision to a small volume with a rapid dose fall-off. This gives it high biological effectiveness with high rates of local control of up to 90% in the first year.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Radiosurgery was traditionally reserved for patients with ≤2 brain metastases,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> although international guidelines increasingly recommend it for the treatment of patients with up to 10 lesions, maximising local control and avoiding the long-term effects of whole-brain radiotherapy.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Fractionated SRS is similar to single-dose SRS in that it is performed under stereotactic conditions, but the total dose is fractionated over several sessions. This improves the therapeutic index, the rate of repair for healthy tissue, and thus the level of tolerance when the lesion is large or in close proximity to healthy organs that are sensitive to radiation, such as the optic pathway. Some studies have also demonstrated the efficacy and safety of hypofractionated radiosurgery schedules based on five fractions of 6–7 Gy or 10 fractions of 4 Gy<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14–16</span></a> in patients with brain metastases larger than 3 cm. Hypofractionation is also applied when using radiation to treat a site that has previously undergone surgery.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Assessment of brain metastasis response</span><p id="par0055" class="elsevierStylePara elsevierViewall">MRI is the technique of choice for assessing brain metastasis response to therapy.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> CT is useful in the initial assessment and in the perioperative setting.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> In general, CT scans are requested in emergency situations, such as the presence of neurological deficits, in order to rule out other complications.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Treatment planning, however, is performed by MRI whenever available as it enables the detection of millimetric metastases which would go undetected by CT, and whose detection is likely to change the choice of treatment.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The United States National Comprehensive Cancer Network (NCCN) guidelines recommend that patients with brain metastases receive follow up every two to three months during the first one to two years, and then every four to six months indefinitely.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Whole neuraxis MRI should be performed if there are signs or symptoms suggestive of intraspinal involvement, and some authors argue for its use in cases of cerebral LM involvement given that up to a third of patients have imaging findings that affect the treatment of LM involvement.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Furthermore, in a review of 72 patients with intraspinal involvement that was secondary to primary tumours originating outside the central nervous system, only half presented with concurrent intracranial involvement.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Response assessment scales</span><p id="par0060" class="elsevierStylePara elsevierViewall">Over the years, different scales with heterogeneous radiological criteria have emerged to assess the response of brain metastases. The Response Assessment in Neuro-Oncology (RANO) working group<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21,22</span></a> sought to unify them by proposing new criteria for the assessment of brain metastases (RANO-BM) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> These criteria define a partial response as a 30% reduction in diameter which must be maintained for four weeks. Progression is determined by 20% growth. In addition, the immunotherapy response assessment for neuro-oncology (iRANO) criteria specifically suggest waiting until the sixth month after the start of treatment before determining progression if the patient is clinically stable.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21,23</span></a> The RANO criteria arose from the need to assess the response in patients included in clinical trials and treated in most cases with systemic therapy.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Considerations in assessing response after radiotherapy treatment</span><p id="par0065" class="elsevierStylePara elsevierViewall">The gross tumour volume (GTV) can be measured on MRI.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> In well-delineated metastases, the GTV is equal to the clinical target volume (CTV), which includes microscopic spread around the tumour. The planning target volume (PTV) adds a safety margin around the CTV to overcome both intrinsic and extrinsic uncertainties when performing the technique due to possible organ movement, the positioning of the patient or technical inaccuracies.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> In single-dose radiosurgery of brain metastases, the PTV is generally equal to the GTV and CTV. In fractionated treatments, a margin of 1 mm is usually added to the CTV to generate the PTV (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Increasing this margin has been shown to lead to an increased risk of radiation necrosis.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">When assessing responses after RT treatment, two phenomena are of interest: the abscopal effect and the bystander effect. The abscopal effect, coined by Robin Mole in 1953, is a radiobiological event occurring outside the irradiated volume in the same individual, i.e., it refers to tumour regression of distant metastases away from the local treatment area in the absence of other treatment (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> The bystander effect describes changes to non-irradiated cells as a result of signals received from neighbouring irradiated cells (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27,28</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Growth assessment after radiotherapy treatment</span><p id="par0075" class="elsevierStylePara elsevierViewall">The growth of a metastasis after irradiation can be caused by treatment-related changes, including both pseudoprogression and radiation necrosis. While some authors group them together as a single entity, they constitute two distinct developments.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">(a) Pseudoprogression and the ‘inflammatory cloud’ sign</span><p id="par0080" class="elsevierStylePara elsevierViewall">Pseudoprogression describes a transient growth caused by inflammatory changes induced by RT or systemic treatment (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21,29</span></a> This growth appears early, typically occurring in the first three months after RT and usually before the sixth month, and occurs in up to 10% of cases.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> Its significance is demonstrated by the fact it is responsible for two thirds of growth after RT.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> It has been associated with good local control and immune response, explaining its higher frequency in patients receiving immunotherapy or in young patients.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31–33</span></a> This phenomenon may be suspected in cases where the ‘inflammatory cloud’ radiological sign is present.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> This sign describes enhancement around the metastasis which is more intense than the tumour tissue itself and has blurred, ill-defined margins, resembling a cloud (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> It represents focal uptake as it does not typically surround the entire metastasis and may correspond to an inflammatory infiltrate.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> In the context of pseudoprogression, one working group presented an image similar to that described without describing the inflammatory cloud itself,<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> and others described enhancement that may not have had a tumoural association.<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">32,34</span></a> The ‘inflammatory cloud’ sign appears both in treatment-naïve metastases and in treated lesions. As with pseudoprogression, the ‘inflammatory cloud’ is associated with good local control (<a class="elsevierStyleCrossRef" href="#fig0030">Fig. 6</a>).<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> The fact that this sign is almost exclusive to melanoma, lung and breast metastases, which are precisely those that are typically associated with tumour-infiltrating lymphocytes (TILs), suggests that the two phenomena may be related.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31,35</span></a> The RANO group has also suggested that pseudoprogression may be linked to immune infiltrates in the context of immunotherapy treatment.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">(b) Radiation necrosis and the ‘incomplete ring’ sign</span><p id="par0085" class="elsevierStylePara elsevierViewall">Radiation necrosis is a complication of RT treatment that has been reported in between 3% and 24% of cases depending on the study series, due to vascular and glial damage.<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">36,37</span></a> Histologically, it is an area of coagulative necrosis with fibroblastic proliferation surrounded by a robust infiltrate of inflammatory cells (haemosiderin-laden lymphocytes and macrophages). This marginal reactive zone is circumscribed by an area of gliosis and demyelination.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">38,39,51</span></a> Radiation necroses may contain some tumour cells.<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39–41</span></a> The percentage is variable and possibly depends on the time of evolution.<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">42,43</span></a> It seems reasonable to think that the structural damage, and in particular the vascular compromise RT produces, impacts on the microenvironment required for tumour cell proliferation, thus favouring cell death and regression, making it likely that the tumoural percentage of the radiation necrosis will progressively reduce. This would explain the absence of recurrences in areas of radiation necrosis over time.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Radiation necrosis rarely occurs within six months of or over three years following the end of RT treatment. Eighty-five per cent of cases appear within the first two years; however, there have been cases reported up to 20 years after treatment.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Risk factors associated with the development of radiation necrosis include the type of primary tumour (renal cancer, lung adenocarcinoma and HER-2 breast cancer), some genetic alterations such as ALK translocations and BRAF37 mutations,<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> the addition of systemic treatments (targeted therapies or immunotherapy), the radiation dose and tumour volume, as well as the volume of irradiated healthy tissue receiving a single-dose of ≥10–12 Gy. Sneed et al.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> carried out a retrospective study evaluating a total of 2,200 brain metastases treated with radiosurgery. They found that the risk of symptomatic side effects was 3% after single radiosurgery, 4% after whole brain RT followed by radiosurgery, 8% after whole brain RT combined with radiosurgery, and 20% after two radiosurgeries on the same lesion. Therefore, when metastatic lesions are large, fractionated treatment minimises the risk of radiation necrosis.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Knowledge of these data allows for a more accurate interpretation of the findings. Thus, the active involvement of radiation oncologists results in more accurate response assessment, which is also enriched by multidisciplinary committees discussing the cases.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Suspicion should be raised whenever there is rapid, exponential growth accompanied by extensive vasogenic oedema.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31,46–48</span></a> The lesion typically increases in size progressively over six months, eventually slowing for up to 15 months before stabilising or decreasing in size.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> They are most frequently located in the frontal lobes, followed by the area around the ventricles and the corpus callosum.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> In contrast, the resistance of the brainstem to radiation makes it an unusual location for radiation necrosis.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> When multifocal, radiation necrosis is suspected when findings are on both sides of anatomical boundaries such as the brain sickle or the tentorium. In other words, radiation necrosis is suspected when necrotic enhancing lesions are detected on both sides of these structures with no clear continuity between them.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Radiologically, radiation necrosis is a highly patchy, irregular lesion with heterogeneous peripheral enhancement that resembles cut green pepper, Swiss cheese or soap bubbles.<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> The tissue is disorganised and unstructured, with no delimitation of a mass when using basic sequences.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> Multiple punctate or linear areas are due to the presence of blood degradation products, calcifications and a liquefactive component (necrosis). If there is an ‘incomplete ring enhancement’ sign or a C shape (<a class="elsevierStyleCrossRef" href="#fig0035">Fig. 7</a>) with its opening towards the pial or ventricular surface, radiation necrosis is suspected.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> This could be attributed to the associated demyelination process.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p><elsevierMultimedia ident="fig0035"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">In addition, the area of aseptic coagulative necrosis can contain a viscous pus-like material with abundant polymorphonuclear leukocytes,<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> which explains the restricted diffusion and the low apparent diffusion coefficient (ADC) value identified in the centre of radiation necrosis mainly in the subacute phase (<a class="elsevierStyleCrossRef" href="#fig0040">Fig. 8</a>).<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31,40,53,54</span></a> Diffusibility increases over time, probably due to the degradation of blood products.</p><elsevierMultimedia ident="fig0040"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">The RANO group recognises the need to use imaging techniques in addition to standard MRI in cases of suspected RT-related changes.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Therefore, not all growth above 20% should be considered progression. Nor is waiting until the sixth month in patients treated with immunotherapy a guarantee that the finding signals tumour recurrence, given that radiation necrosis may progressively grow for more than a year before stabilising.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p></span></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">MRI of brain metastases</span><p id="par0120" class="elsevierStylePara elsevierViewall">The basic MRI protocol typically includes T1-weighted, T2-weighted, T2-fluid attenuated inversion recovery (T2-FLAIR), diffusion-weighted and a 3D T1-weighted sequence both non-contrast and following the administration of a gadolinium-based contrast.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Contrast-enhanced FLAIR is more sensitive than contrast-enhanced T1-weighted sequences in the detection of LM disease.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Maximum intensity projection (MIP) reconstructions are useful for detecting small metastases using a contrast-enhanced 3D T1-weighted sequence and reconstructions of four or five millimetres thickness.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Immediate post-surgical MRI is necessary to estimate the tumour remnant. It should ideally be performed within the first 48 h, and no later than 72 h after surgery, to avoid ischaemic or inflammatory enhancements.<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">56,57</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">When assessing response to treatment, tumour growth involves a complex differential diagnosis between tumour recurrence and treatment-related changes. This is where new MRI techniques play an important role.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> There is much ongoing research into diffusion and perfusion imaging, spectroscopy and PET, where several promising avenues of added value have already been identified.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a></p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Diffusion-weighted imaging</span><p id="par0145" class="elsevierStylePara elsevierViewall">Diffusion refers to the random movement of water molecules. The ADC describes the rate of diffusional movement. The ‘b’ value represents the strength of the diffusion gradient, and is usually within the range of 900 to 1,000 s/mm<span class="elsevierStyleSup">2</span>.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">Diffusion-weighted imaging (DWI) can help us differentiate metastases from the annular enhancement of abscesses given that the latter have a viscous purulent content in the centre of the lesion that restricts diffusion.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The role of DWI is indisputable in post-surgical studies as it reveals acute ischaemic infarction.<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a> In MRI follow-up scans, ischaemic enhancement could be misinterpreted as early recurrence if there is no knowledge of the pre-existing infarct in the area.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">The usefulness of DWI in response assessment is contingent on the presence of a tumour with a high nucleus/cytoplasm ratio, which most commonly translates to a lung, breast, colon or testicular tumour.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> In these cases, restriction of the enhancing component is expected. Conversely, tumour recurrence will not display restriction if the original metastasis did not. In general, treated lesions that are progressing well will decrease in size as the restriction subsides (<a class="elsevierStyleCrossRef" href="#fig0045">Fig. 9</a>). Conflicting results have been published on the relationship between the central diffusivity of the necrotic area and tumour progression,<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">38,53</span></a> with most studies reporting increased central diffusion of the necrotic area in cases of tumour recurrence. Thus, the sign of central restriction in the necrotic area is suggestive of radiation necrosis.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31,53,54</span></a></p><elsevierMultimedia ident="fig0045"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Perfusion imaging</span><p id="par0165" class="elsevierStylePara elsevierViewall">The main techniques used to perform MR perfusion studies are dynamic susceptibility contrast (DSC), dynamic contrast enhanced (DCE) and Arterial Spin Labelling (ASL).<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">DSC obtains information from the first passage of paramagnetic contrast through the cerebrovascular system. It estimates the relative cerebral blood volume (rCBV), which is a reflection of neoangiogenesis. This is a validated technique for the diagnosis and management of brain tumours.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">T1-weighted sequence DCE has some advantages over DSC in that it has a higher spatial resolution and is less susceptible to artefacts;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> however, acquisition times are longer. T1-weighted DCE enables the calculation of several parameters related to vascular permeability, such as K<span class="elsevierStyleSup">trans</span> and plasma volume. K<span class="elsevierStyleSup">trans</span> is a transfer constant that describes the diffusivity of gadolinium chelates through the capillary endothelium.<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">60,61</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">ASL is a perfusion method that does not use contrast agents. It uses magnetised blood as an endogenous tracer. However, it is limited in comparisons to other methods by a low signal-to-noise ratio and a lower spatial resolution.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">DSC perfusion imaging is a valuable tool in the differential diagnosis of high-grade glioma from brain metastasis, due to the difference in peritumoural rCBV between the two types of tumours. This difference is explained by the absence of microscopic infiltration beyond the external enhancing margin of the metastasis. By contrast, the peritumoural region of gliomas harbours a combination of vasogenic oedema and infiltrative non-enhancing tumour tissue.<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">62–65</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Perfusion imaging helps differentiate between tumour recurrence and radiation necrosis.<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">61,66</span></a> Morabito et al.<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> set an optimal cut-off point for rCBV at 1.23, with 88% sensitivity (sens.) and 75% specificity (spec.), while the cut-off point for the K<span class="elsevierStyleSup">trans</span> constant was set at 28.76, with 89% sens. and 97% spec. Barajas et al.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> set a cut-off point for rCBV at 1.54 enabling the detection of recurrence with higher sens. and spec. values. In their series, all rCBV values are below 1.35 in radiation necrosis. Other authors suggest that an rCBV to grey matter that is greater than 1.85 excludes the possibility of radiation necrosis. However, the proximity of the metastases to the cerebral cortex and the size of the metastases limit the technique. Thus, the absence of an increase in rCBV does not rule out tumour progression, especially in cystic metastases, where the thin wall may result in an undetectable rCBV. These studies may include examples of radiation necrosis in chronic phases, and it is important to keep in mind that radiation necrosis typically exhibits an elevated rCBV in the acute phase (<a class="elsevierStyleCrossRef" href="#fig0050">Fig. 10</a>).<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p><elsevierMultimedia ident="fig0050"></elsevierMultimedia><p id="par0195" class="elsevierStylePara elsevierViewall">DCE and ASL also play a role in the differential diagnosis between high-grade gliomas and metastasis.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Magnetic resonance spectroscopy</span><p id="par0200" class="elsevierStylePara elsevierViewall">Magnetic resonance spectroscopy evaluates the chemical content of a volume of tissue and generates a frequency spectrum expressed in parts per million (ppm). Multiple metabolites have proven useful in clinical practice.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> N-acetyl-aspartate (NAA) is a marker of neuronal viability and resonates at 2 ppm chemical shift. Choline (Cho) is a marker of cell membrane turnover and resonates at 3.2 ppm chemical shift. Lactate is a marker of metabolism and resonates at 1.3 ppm chemical shift. Myo-inositol is a marker of gliosis and resonates at 3.5 ppm chemical shift. Creatine (peak at 3 ppm chemical shift) is assumed to be stable and is used as an internal standard.<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">60,67</span></a></p><p id="par0205" class="elsevierStylePara elsevierViewall">Elevated Cho/NAA levels in tumours are associated with higher cell density, proliferation rate and cell death rate. Elevated levels of Cho, lactate and lipids are seen in metastases.<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a> NAA is absent in metastases due to the lack of neurons. Spectroscopy enables peritumoural infiltration analysis which can be used to differentiate metastasis from a primary tumour. Glioblastomas tend to exhibit elevated choline/creatine ratios and lymphomas have higher Co/Cr and lipid-lactate/Cr ratios than metastases.<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">60,65,68,69</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">In response assessment, MR spectroscopy alone provides a moderate diagnostic performance due to the fact that treatment-related changes, including radiation necrosis, reveal elevated Cho/Cr and Cho/NAA ratios (<a class="elsevierStyleCrossRef" href="#fig0050">Fig. 10</a>), attributable to a higher cell membrane turnover.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a></p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Positron Emission Tomography (PET)</span><p id="par0215" class="elsevierStylePara elsevierViewall">PET uses a variety of radiotracers which identify different metabolic pathways. It is a complementary test used in the differential diagnosis of tumour recurrence from treatment-induced changes. 18F-fluorodeoxy-glucose (18F-FDG) is not the ideal radiotracer for brain tumour assessment due to the high physiological uptake in the brain, although, thanks to dual-time-point imaging, late acquisition improves diagnostic sensitivity.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a> Radiolabelled amino acid-based tracers have proved to be a useful tool in metastasis response assessment, specifically 11C-methyl-methionine (11C-MET).<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a> Others have also attracted considerable interest, such as 18F-fluorophenylalanine (18F-DOPA) and 18F-fluoroethyl-L-tyrosine (18F-FET), as the 18F-fluorine content improves their availability.<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a> These techniques provide good diagnostic accuracy, although they can give rise to false positives in situations that alter the blood-brain barrier (ischaemia, haemorrhage, infection or demyelination). Acute-phase radiation necrosis exhibits intense uptake of FDG and other radiotracers.<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">74,75</span></a></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusion</span><p id="par0220" class="elsevierStylePara elsevierViewall">Brain metastasis response assessment after RT treatment remains a challenge both clinically and radiologically. The multiparametric approach is most useful when growth is detected after treatment. However, the presence of abrupt and exponential growth after RT, even when advanced techniques suggest tumour recurrence, should be analysed with caution as it is likely to correspond to inflammatory changes. In these cases, close and regular follow-up often confirms the suspicion as the lesion regresses. For this reason, it is important that the type of treatment received is made known and a multidisciplinary approach is applied in the assessment in order to avoid unnecessary aggressive management or withdrawal from a clinical trial.</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0225" class="elsevierStylePara elsevierViewall">This research has not received funding support from public sector agencies, the business sector or any non-profit organisations.</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0230" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres2128835" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1808024" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres2128834" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1808025" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Treatment of brain metastases" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Assessment of brain metastasis response" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Response assessment scales" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Considerations in assessing response after radiotherapy treatment" ] 2 => array:3 [ "identificador" => "sec0030" "titulo" => "Growth assessment after radiotherapy treatment" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "(a) Pseudoprogression and the ‘inflammatory cloud’ sign" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "(b) Radiation necrosis and the ‘incomplete ring’ sign" ] ] ] ] ] 7 => array:3 [ "identificador" => "sec0045" "titulo" => "MRI of brain metastases" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0050" "titulo" => "Diffusion-weighted imaging" ] 1 => array:2 [ "identificador" => "sec0055" "titulo" => "Perfusion imaging" ] 2 => array:2 [ "identificador" => "sec0060" "titulo" => "Magnetic resonance spectroscopy" ] ] ] 8 => array:2 [ "identificador" => "sec0065" "titulo" => "Positron Emission Tomography (PET)" ] 9 => array:2 [ "identificador" => "sec0070" "titulo" => "Conclusion" ] 10 => array:2 [ "identificador" => "sec0075" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "sec0080" "titulo" => "Conflicts of interest" ] 12 => array:2 [ "identificador" => "xack738839" "titulo" => "Acknowledgements" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-11-15" "fechaAceptado" => "2023-04-02" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1808024" "palabras" => array:11 [ 0 => "Malignant brain neoplasm" 1 => "Local neoplasm recurrence" 2 => "Stereotactic radiosurgery" 3 => "Radiation-Induced abnormality" 4 => "Magnetic resonance imaging" 5 => "Inflammatory Cloud sign" 6 => "Incomplete ring enhancement sign" 7 => "Perfusion magnetic resonance imaging" 8 => "Diffusion MRI" 9 => "Multiparametric MRI" 10 => "Tumor-Infiltrating lymphocytes" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1808025" "palabras" => array:11 [ 0 => "Neoplasia cerebral maligna" 1 => "Recurrencia tumoral local" 2 => "Radiocirugía estereotáxica" 3 => "Anomalía inducida por radiación" 4 => "Resonancia magnética" 5 => "Signo de la nube inflamatoria" 6 => "Signo del realce en anillo incompleto" 7 => "Resonancia magnética de perfusión" 8 => "Resonancia magnética de difusión" 9 => "Resonancia magnética multiparamétrica" 10 => "Linfocitos infiltrantes de tumor" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">MRI is the cornerstone in the evaluation of brain metastases. The clinical challenges lie in discriminating metastases from mimickers such as infections or primary tumors and in evaluating the response to treatment. The latter sometimes leads to growth, which must be framed as pseudo-progression or radionecrosis, both inflammatory phenomena attributable to treatment, or be considered as recurrence. To meet these needs, imaging techniques are the subject of constant research. However, an exponential growth after radiotherapy must be interpreted with caution, even in the presence of results suspicious of tumor progression by advanced techniques, because it may be due to inflammatory changes. The aim of this paper is to familiarize the reader with inflammatory phenomena of brain metastases treated with radiotherapy and to describe two related radiological signs: "the inflammatory cloud" and "incomplete ring enhancement", in order to adopt a conservative management with close follow-up.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">La resonancia magnética es la piedra angular en la evaluación de las metástasis cerebrales. Los retos clínicos residen en discriminar las metástasis de imitadores como infecciones o tumores primarios y en evaluar la respuesta al tratamiento. Éste, en ocasiones, condiciona un crecimiento, que debe encuadrarse como una pseudoprogresión o una radionecrosis, ambos fenómenos inflamatorios atribuibles al tratamiento; o bien considerarse como una recurrencia. Para responder a estas necesidades, las técnicas de imagen son objeto de constantes investigaciones. No obstante, un crecimiento exponencial tras radioterapia, debe interpretarse con cautela, incluso ante resultados sospechosos de progresión por técnicas avanzadas, ya que puede tratarse de cambios inflamatorios. El objetivo de este trabajo es familiarizar al lector con los fenómenos inflamatorios de las metástasis cerebrales tratadas con radioterapia y describir dos signos radiológicos relacionados: “la nube inflamatoria” y el “realce en anillo incompleto”, con el fin de adoptar un manejo conservador con seguimiento estrecho.</p></span>" ] ] "multimedia" => array:11 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 858 "Ancho" => 3258 "Tamanyo" => 322707 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Radiotherapy planning image for a metastasis in the right hippocampus (coloured orange and marked with arrow) (A). Organs at risk are delineated including the eyeballs, chiasm, optic nerves and midbrain. The gross tumour volume (GTV) shown in orange is the volume of the metastasis that we can delineate on the MRI. In metastases, the GTV is equal to the clinical target volume (CTV), as there is no peritumoural infiltration. The planning target volume (PTV) may add a margin of 0 mm for radiosurgery or a minimum of 1 mm (green halo) for fractionated treatments.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2127 "Ancho" => 3258 "Tamanyo" => 590286 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Diagram depicting the abscopal effect, where there is a metastatic cell response (in white) when cells in another organ are irradiated (shown in blue) (A). Chest CT coronal image for lung cancer radiotherapy planning (B). Contrast-enhanced 3D T1-weighted images prior to lung irradiation (C, D) and two months after treatment (E, F) showing a response in both brain metastases in the absence of other treatments.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2855 "Ancho" => 3008 "Tamanyo" => 675041 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Diagram depicting the bystander effect (A), where there is a metastatic cell response (in light blue) when neighbouring cells are irradiated (shown in blue). Head CT image showing treatment planning with radiotherapy (B and C). Contrast-enhanced 3D T1-weighted images prior to fractionated radiotherapy (D) and two months after treatment (E), showing a response in the radiated areas of the brain with metastasis (arrows) and the right thalamic lesion (circle) not included in the irradiation field of any of the lesions, and in the absence of any other targeted treatment. Note the appearance of a new left frontal metastasis (E) (arrowhead).</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 824 "Ancho" => 3258 "Tamanyo" => 192910 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pseudoprogression. Ovarian cancer patient with brain metastasis treated with radiosurgery. Contrast-enhanced 3D T1-weighted cross-sectional images: pre-treatment (A), at three months (B), at six months (C) and at nine months (D). A transient growth is shown as the lesion responds progressively at six and nine months. The ‘inflammatory cloud’ sign is visible in the three-month image (B) in the form of intense peripheral enhancement (arrows) surrounding the tumour tissue (arrowhead) with extensive associated vasogenic oedema (*). Note how this tumour tissue enhances less intensely than the ‘cloud’ (arrows) and how it has decreased in size with respect to the previous one, although the overall volume of enhancing tissue is greater in the three-month MRI. The MRI scan performed four years later (not shown) shows no recurrence in this area.</p>" ] ] 4 => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 2307 "Ancho" => 2175 "Tamanyo" => 224005 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">‘Inflammatory cloud’ sign. Contrast-enhanced 3D T1-weighted images show an area of intense, focal and peripheral enhancement that could correspond to an inflammatory infiltrate (arrows) around the tissue interpreted as tumour tissue (arrowhead). The blurred margins give it a cloud-like appearance. In Figure A, the metastasis is located in close relation to the sigmoid sinus (*).</p>" ] ] 5 => array:8 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 2437 "Ancho" => 2175 "Tamanyo" => 277600 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Partial response associated to the ‘inflammatory cloud’ sign. Case 1: Lung cancer patient. Contrast-enhanced 3D T1-weighted cross-sectional images: pre-treatment (A), and at three months after radiotherapy treatment (B), which show a reduction in the size of the tumour tissue (arrowhead) at the same time that there is a diffuse focal enhancement similar to a ‘cloud’ (arrows in B). Case 2: Breast cancer patient. Contrast-enhanced 3D T1-weighted cross-sectional images at six months after treatment (C), which show the ‘inflammatory cloud’ sign (arrows). Image D shows a partial response in the cluster of LM metastases (arrowheads).</p>" ] ] 6 => array:8 [ "identificador" => "fig0035" "etiqueta" => "Figure 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 2328 "Ancho" => 2175 "Tamanyo" => 319349 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">‘Incomplete ring enhancement’ sign open to the ependymal surface in two cases of radiation necrosis. Case 1: Breast cancer patient with brain metastasis (not shown) operated on and treated with RT. 3D T1-weighted cross-sectional images after fractionated RT treatment of the site, at six months (A) showing radiation necrosis with ‘C’ enhancement (arrow), open to the ependymal surface (*) of the right frontal horn, and at 13 months (B), showing regression of the lesion. Case 2: Patient with seminomatous type pineal germinoma treated with chemo- and radiotherapy (ventricular PTV): 32 Gy in 20 sessions of 1.6 Gy/session and PTV boost in the suprasellar region: 46 Gy in 20 sessions of 2.3 Gy/session. 3D T1-weighted cross-sectional images at two years (C) and at four years (D) after fractionated RT treatment. Areas of radiation necrosis (arrows) appear at 20 months (not shown) and maintain a progressive increase in size over five months until 24 months (C), after which they begin to decrease in size. Note the opening to the ependymal surface of the third ventricle (*) and the crossing of anatomical boundaries with non-communicating lesions in both thalami (another lesion was located in the corpus callosum, not shown).</p>" ] ] 7 => array:8 [ "identificador" => "fig0040" "etiqueta" => "Figure 8" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr8.jpeg" "Alto" => 1550 "Ancho" => 2174 "Tamanyo" => 147252 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0040" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Diffusion in radiation necrosis. Breast cancer patient with an operated brain metastasis receiving radiotherapy on the surgical site (fractionated stereotactic radiation therapy with 40 Gy in 10 fractionations). At five months, whole brain RT was performed with a good response from multiple lesions. After 10 months, another lesion close to the site is treated with radiosurgery (20 Gy). At 18 months, the contrast-enhanced 3D T1-weighted cross-sectional image (A) shows a new lesion in the same irradiated area with peripheral patchy enhancement. In diffusion-weighted imaging (B) we identify central restriction (arrows), which suggests radiation necrosis. The follow-up at 27 months (C, D) confirms the suspicion, demonstrating a reduction of the lesion, oedema and restriction, having received no further treatment other than steroids. The central hypersignal at 27 months (C) corresponds to calcifications which are also seen on the non-contrast 3D T1-weighted sequence and on CT (not shown).</p>" ] ] 8 => array:8 [ "identificador" => "fig0045" "etiqueta" => "Figure 9" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr9.jpeg" "Alto" => 1318 "Ancho" => 3258 "Tamanyo" => 303065 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0045" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Patient with microcytic lung cancer treated with prophylactic whole brain radiotherapy; the patient progresses at six months (A and D). Treatment planning images for radiotherapy treatment with 35 Gy in 7 fractionations (A, D) at two months after radiotherapy treatment (B, E) and at four months (C, F). Contrast-enhanced 3D T1-weighted cross-sectional images (arrows) demonstrate a progressive reduction in the volume of the metastasis. The lesions in the diffusion-weighted images (*) exhibit a reduction in restriction in response to treatment.</p>" ] ] 9 => array:8 [ "identificador" => "fig0050" "etiqueta" => "Figure 10" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr10.jpeg" "Alto" => 2526 "Ancho" => 3258 "Tamanyo" => 735953 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0050" "detalle" => "Figure 1" "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Advanced MRI in radiation necrosis. Patient with adenocarcinoma of the colon with a left frontal brain metastasis treated with surgery and fractionated radiotherapy of the surgical site with 10 fractionations of 4 Gy. Six months after radiotherapy treatment (A, B, C, F, G) contrast-enhanced T2-weighted (A) and 3D T1-weighted (B) sequences demonstrate a lesion with peripheral enhancement and irregular margins. The T2* perfusion colour map (C) and time-signal intensity curve (F) reflect an increase in relative cerebral blood volume (arrows) of 2.9. The spectroscopy with TE of 144 ms (G) shows an increase in Cho/Cr and Cho/NAA ratios with a sharp lipid peak. However, the type of enhancement and the extensive oedema (*), as well as the thinning of the enhancement towards the pial surface (arrowhead), should raise suspicion of radiation necrosis. Subsequent follow-up MRI (D,E) demonstrates a reduction in size confirming the suspicion of radiation necrosis.</p>" ] ] 10 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0055" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">DP: disease progression; L: lesion; MD: maximum diameter; Measurement: uni- or bidimensional; PR: partial response; R: response; RANO: response assessment in neuro-oncology; RECIST: response evaluation criteria in solid tumours; S: steroids; /: not included, 0: not specified.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Criteria \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Target L. \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No. target L maximum/measurement \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PR \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MR validation of R \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">DP \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Minimum change to define DP \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">S \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RECIST 1.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥10 MD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥30% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥20% in the sum of lesions, new lesions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RECIST 1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥10 MD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥30% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥20% in the sum of lesions, new lesions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 ≥ 5 mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Macdonald \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥50% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes ≥ 4 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥25%, new lesions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stable or declining \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stable or improving \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">WHO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">All/2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥50% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes ≥ 4 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥25% in the sum of lesions, ≥25% in a new lesion, new lesions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">/ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RANO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥10 MD (5 mm)<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥30%<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes ≥ 4 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥20% in sum of lesions, new lesions,<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> DP in T2/FLAIR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥20% in MT<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stable or declining compared to baseline study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stable or improving \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3509633.png" ] ] ] "notaPie" => array:4 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">One diameter is considered for assessment, but the perpendicular must be at least 5 mm.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">In the sum of the MD of the target lesions. In the case of patients with several lesions, if only one or two have increased in size, these should be considered as target lesions.</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">New lesions except in immunotherapy-based trials.</p>" ] 3 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "d" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">A minimum increase of ≥ 5 mm in absolute value is required in at least one of the lesions.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Characteristics of response assessment criteria in neuro-oncology trials.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:75 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Soffietti" 1 => "P. Cornu" 2 => "J. Delattre" 3 => "R. Grant" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-1331.2006.01506.x" "Revista" => array:6 [ "tituloSerie" => "Eur J Neurol" "fecha" => "2006" "volumen" => "13" "paginaInicial" => "674" "paginaFinal" => "681" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16834697" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical treatment for brain metastases: prognostic factors and survival in 177 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.M. Stark" 1 => "H. Tscheslog" 2 => "R. Buhl" 3 => "J. Held-Feindt" 4 => "H.M. Mehdorn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10143-004-0364-3" "Revista" => array:5 [ "tituloSerie" => "Neurosurg Rev" "fecha" => "2005" "volumen" => "28" "paginaInicial" => "115" "paginaFinal" => "119" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distribution of brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.Y. Delattre" 1 => "G. Krol" 2 => "H.T. Thaler" 3 => "J.B. Posner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/ARCHNEUR.1988.00520310047016" "Revista" => array:5 [ "tituloSerie" => "Arch Neurol" "fecha" => "1988" "volumen" => "45" "paginaInicial" => "741" "paginaFinal" => "744" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of magnetic resonance imaging in the management of brain metastases: diagnosis to prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Zakaria" 1 => "K. Das" 2 => "M. Bhojak" 3 => "M. Radon" 4 => "C. Walker" 5 => "M.D. Jenkinson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1470-7330-14-8" "Revista" => array:6 [ "tituloSerie" => "Cancer Imaging" "fecha" => "2014" "volumen" => "14" "paginaInicial" => "1" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25609460" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging of brain metastases. Comparison of computerized tomography (CT) and magnetic resonance imaging (MRI)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.J. Taphoorn" 1 => "J.J. Heimans" 2 => "M.C. Kaiser" 3 => "R.G. de Slegte" 4 => "F.C. Crezee" 5 => "J. Valk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF00343862" "Revista" => array:6 [ "tituloSerie" => "Neuroradiology" "fecha" => "1989" "volumen" => "31" "paginaInicial" => "391" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2594181" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.B. Lassman" 1 => "L.M. DeAngelis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0733-8619(02)00035-x" "Revista" => array:6 [ "tituloSerie" => "Neurol Clin" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "1" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12690643" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptomeningeal metastasis from systemic cancer: review and update on management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Wang" 1 => "M.S. Bertalan" 2 => "P.K. Brastianos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/CNCR.30911" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2018" "volumen" => "124" "paginaInicial" => "21" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29165794" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptomeningeal metastases: a RANO proposal for response criteria" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Chamberlain" 1 => "L. Junck" 2 => "D. Brandsma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/neuonc/now183" "Revista" => array:6 [ "tituloSerie" => "Neuro Oncol" "fecha" => "2017" "volumen" => "19" "paginaInicial" => "484" "paginaFinal" => "492" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28039364" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.D. Brown" 1 => "K.V. Ballman" 2 => "J.H. Cerhan" 3 => "R. Soffietti" 4 => "R. Rudà" 5 => "J. Raizer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(17)30441-2" "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2017" "volumen" => "18" "paginaInicial" => "1049" "paginaFinal" => "1060" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28687377" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E. Le Rhun" 1 => "M. Guckenberger" 2 => "M. Smits" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.annonc.2021.07.016" "Revista" => array:6 [ "tituloSerie" => "Ann Oncol" "fecha" => "2021" "volumen" => "32" "paginaInicial" => "1332" "paginaFinal" => "1347" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34364998" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.W. Andrews" 1 => "C.B. Scott" 2 => "P.W. Sperduto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(04)16250-8" "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "2004" "volumen" => "363" "paginaInicial" => "1665" "paginaFinal" => "1672" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Kondziolka" 1 => "A. Patel" 2 => "L.D. Lunsford" 3 => "A. Kassam" 4 => "J.C. Flickinger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0360-3016(99)00198-4" "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "1999" "volumen" => "45" "paginaInicial" => "427" "paginaFinal" => "434" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10487566" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Yamamoto" 1 => "T. Serizawa" 2 => "T. Shuto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(14)70061-0" "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2014" "volumen" => "15" "paginaInicial" => "387" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24621620" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H.K. Inoue" 1 => "H. Sato" …1 ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13014-014-0231-5" "Revista" => array:5 [ "tituloSerie" => "Radiation Oncology" "fecha" => "2014" "volumen" => "9" "paginaInicial" => "231" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcomes of hypofractionated stereotactic radiotherapy for metastatic brain tumors with high risk factors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11060-012-0912-6" "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "2012" "volumen" => "109" "paginaInicial" => "425" "paginaFinal" => "432" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypofractionated radiosurgery for intact or resected brain metastases: defining the optimal dose and fractionation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1748-717X-8-135" "Revista" => array:5 [ "tituloSerie" => "Radiat Oncol" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "135" "paginaFinal" => "142" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging of brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/2152-7806.111298" "Revista" => array:5 [ "tituloSerie" => "Surg Neurol Int" "fecha" => "2013" "volumen" => "4" "paginaInicial" => "209" "paginaFinal" => "219" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Central nervous system cancers, version 3.2020" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.6004/JNCCN.2020.0052" "Revista" => array:6 [ "tituloSerie" => "J Natl Compr Canc Netw" "fecha" => "2020" "volumen" => "18" "paginaInicial" => "1537" "paginaFinal" => "1570" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comprehensive neuraxis imaging in leptomeningeal metastasis: a retrospective case series" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2217/cns.12.45" "Revista" => array:5 [ "tituloSerie" => "CNS Oncol" "fecha" => "2013" "volumen" => "2" "paginaInicial" => "121" "paginaFinal" => "128" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leptomeningeal metastases of the spine: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.21873/anticanres.15519" "Revista" => array:6 [ "tituloSerie" => "Anticancer Res" "fecha" => "2022" "volumen" => "42" "paginaInicial" => "619" "paginaFinal" => "628" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Response assessment criteria for brain metastases: proposal from the RANO group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(15)70057-4" "Revista" => array:5 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2015" "volumen" => "16" "paginaInicial" => "270" "paginaFinal" => "278" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(13)70311-5" "Revista" => array:5 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2013" "volumen" => "14" "paginaInicial" => "396" "paginaFinal" => "406" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunotherapy response assessment in neuro-oncology: a report of the RANO working group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(15)00088-1" "Revista" => array:5 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2015" "volumen" => "16" "paginaInicial" => "534" "paginaFinal" => "542" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dose-response effect and dose-toxicity on stereotactic radiotherapy for brain metastases: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3390/cancers13236086" "Revista" => array:5 [ "tituloSerie" => "Cancers." "fecha" => "2021" "volumen" => "13" "paginaInicial" => "6086" "paginaFinal" => "6108" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiosurgery with or without A 2-mm margin for 93 single brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijrobp.2007.11.002" "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2008" "volumen" => "70" "paginaInicial" => "766" "paginaFinal" => "772" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The controversial abscopal effect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ctrv.2005.03.004" "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rev" "fecha" => "2005" "volumen" => "31" "paginaInicial" => "159" "paginaFinal" => "172" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The mechanisms of radiation-induced bystander effect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Biomed Phys Eng" "fecha" => "2014" "volumen" => "4" "paginaInicial" => "163" "paginaFinal" => "172" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bystander effects and radiotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rpor.2014.08.004" "Revista" => array:6 [ "tituloSerie" => "Reports of Practical Oncology and Radiotherapy" "fecha" => "2015" "volumen" => "20" "paginaInicial" => "12" "paginaFinal" => "21" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging changes following stereotactic radiosurgery for metastatic intracranial tumors: differentiating pseudoprogression from tumor progression and its effect on clinical practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10143-013-0504-8" "Revista" => array:6 [ "tituloSerie" => "Neurosurg Rev" "fecha" => "2014" "volumen" => "37" "paginaInicial" => "193" "paginaFinal" => "201" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transient enlargement of contrast uptake on MRI after linear accelerator (linac) stereotactic radiosurgery for brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0360-3016(00)01511-X" "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2001" "volumen" => "49" "paginaInicial" => "1339" "paginaFinal" => "1349" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiologic assessment of brain metastases after radiosurgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Doctoral Thesis" "fecha" => "2017" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/2015.6.JNS142763" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "2015" "volumen" => "125" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship between pattern of enhancement and local control of brain metastases after radiosurgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0360-3016(00)01584-4" "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2001" "volumen" => "50" "paginaInicial" => "139" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pseudo-progression after stereotactic radiotherapy of brain metastases: lesion analysis using MRI cine-loops" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11060-014-1519-x" "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "2014" "volumen" => "119" "paginaInicial" => "437" "paginaFinal" => "443" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain metastasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41568-019-0220-y" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Cancer" "fecha" => "2020" "volumen" => "20" "paginaInicial" => "4" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distinguishing recurrent intra-axial metastatic tumor from radiation necrosis following gamma knife radiosurgery using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3174/ajnr.A1362" "Revista" => array:6 [ "tituloSerie" => "AJNR Am J Neuroradiol" "fecha" => "2009" "volumen" => "30" "paginaInicial" => "367" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between radiation necrosis and tumor biology after stereotactic radiosurgery for brain metastasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijrobp.2016.08.039" "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2016" "volumen" => "96" "paginaInicial" => "1060" "paginaFinal" => "1069" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroimaging in neuro-oncology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/J.NURT.2009.05.002" "Revista" => array:6 [ "tituloSerie" => "Neurotherapeutics" "fecha" => "2009" "volumen" => "6" "paginaInicial" => "465" "paginaFinal" => "477" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comprehensive review of MR imaging changes following radiosurgery to 500 brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3174/ajnr.A2668" "Revista" => array:6 [ "tituloSerie" => "Am J Neuroradiol" "fecha" => "2011" "volumen" => "32" "paginaInicial" => "1885" "paginaFinal" => "1892" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical and pathological characteristics of brain metastasis resected after failed radiosurgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1227/01.NEU.0000359318.90478.69" "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2010" "volumen" => "66" "paginaInicial" => "208" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stereotactic radiosurgery: adjacent tissue injury and response after high-dose single fraction radiation: Part I--Histology, imaging, and molecular events" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1227/01.NEU.0000249191.23162.D2" "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2007" "volumen" => "60" "paginaInicial" => "31" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histopathology of brain metastases after radiosurgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000331169" "Revista" => array:4 [ "tituloSerie" => "Prog Neurol Surg" "fecha" => "2012" "paginaInicial" => "30" "paginaFinal" => "38" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does gamma knife surgery stimulate cellular immune response to metastatic brain tumors? A histopathological and immunohistochemical study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2005.102.s_supplement.0180" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "2005" "volumen" => "102" "paginaInicial" => "180" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11060-015-1881-3" "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "2015" "volumen" => "125" "paginaInicial" => "149" "paginaFinal" => "156" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/2014.10.JNS141610" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "2015" "volumen" => "123" "paginaInicial" => "373" "paginaFinal" => "386" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Universal scaling laws rule explosive growth in human cancers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/S41567-020-0978-6" "Revista" => array:6 [ "tituloSerie" => "Nat Phys" "fecha" => "2020" "volumen" => "16" "paginaInicial" => "1232" "paginaFinal" => "1237" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth dynamics of brain metastases differentiate radiation necrosis from recurrence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/noajnl/vdac179" "Revista" => array:5 [ "tituloSerie" => "Neurooncol Adv" "fecha" => "2022" "volumen" => "5" "paginaInicial" => "1" "paginaFinal" => "8" ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain metastasis response to stereotactic radio surgery: a mathematical approach" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3390/math9070716" "Revista" => array:5 [ "tituloSerie" => "Mathematics" "fecha" => "2021" "volumen" => "9" "paginaInicial" => "716" "paginaFinal" => "735" ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiation necrosis in the brain: imaging features and differentiation from tumor recurrence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/rg.325125002" "Revista" => array:6 [ "tituloSerie" => "Radiographics" "fecha" => "2012" "volumen" => "32" "paginaInicial" => "1343" "paginaFinal" => "1359" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ADULT BRAIN response assessment in neuro-oncology criteria for gliomas: practical approach using conventional and advanced techniques" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3174/ajnr.A6358" "Revista" => array:5 [ "tituloSerie" => "Am J Neuroradiol." "fecha" => "2020" "volumen" => "41" "paginaInicial" => "10" "paginaFinal" => "20" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological review of late cerebral radionecrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/S10014-008-0233-9" "Revista" => array:5 [ "tituloSerie" => "Brain Tumor Pathol" "fecha" => "2008" "volumen" => "25" "paginaInicial" => "51" "paginaFinal" => "58" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of the layering pattern of the apparent diffusion coefficient (ADC) for differentiation of radiation necrosis from tumour progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00330-012-2638-4" "Revista" => array:5 [ "tituloSerie" => "Eur Radiol" "fecha" => "2013" "volumen" => "23" "paginaInicial" => "879" "paginaFinal" => "886" ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The centrally restricted diffusion sign on MRI for assessment of radiation necrosis in metastases treated with stereotactic radiosurgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/S11060-021-03879-4" "Revista" => array:5 [ "tituloSerie" => "J Neurooncol" "fecha" => "2021" "volumen" => "155" "paginaInicial" => "325" "paginaFinal" => "333" ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic accuracy of centrally restricted diffusion in the differentiation of treatment-related necrosis from tumor recurrence in high-grade gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3174/ajnr.A5485" "Revista" => array:5 [ "tituloSerie" => "Am J Neuroradiol" "fecha" => "2018" "volumen" => "39" "paginaInicial" => "260" "paginaFinal" => "264" ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain metastases: neuroimaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/B978-0-12-811161-1.00007-4" "Revista" => array:6 [ "tituloSerie" => "Handb Clin Neurol" "fecha" => "2018" "volumen" => "149" "paginaInicial" => "89" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Timing of postoperative magnetic resonance imaging (MRI) following glioma resection: shattering the 72 hour window" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pak Med Assoc" "fecha" => "2019" "volumen" => "69" "paginaInicial" => "1224" "paginaFinal" => "1225" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Time window for postoperative reactive enhancement after resection of brain tumors: less than 72 hours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/2014.9.FOCUS14479" "Revista" => array:5 [ "tituloSerie" => "Neurosurg Focus" "fecha" => "2014" "volumen" => "37" "paginaInicial" => "1" "paginaFinal" => "6" ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brainstem stroke: anatomy, clinical and radiological findings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.sult.2013.01.004" "Revista" => array:6 [ "tituloSerie" => "Semin Ultrasound CT MR" "fecha" => "2013" "volumen" => "34" "paginaInicial" => "131" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracerebral metastasis showing restricted diffusion: correlation with histopathologic findings" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/J.EJRAD.2009.03.004" "Revista" => array:6 [ "tituloSerie" => "Eur J Radiol" "fecha" => "2010" "volumen" => "74" "paginaInicial" => "117" "paginaFinal" => "120" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MR perfusion and MR spectroscopy of brain neoplasms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rcl.2019.07.008" "Revista" => array:6 [ "tituloSerie" => "Radiol Clin North Am" "fecha" => "2019" "volumen" => "57" "paginaInicial" => "1177" "paginaFinal" => "1188" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DCE and DSC perfusion MRI diagnostic accuracy in the follow-up of primary and metastatic intra-axial brain tumors treated by radiosurgery with cyberknife" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13014-019-1271-7" "Revista" => array:6 [ "tituloSerie" => "Radiat Oncol" "fecha" => "2019" "volumen" => "14" "paginaInicial" => "65" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perfusion MRI as a diagnostic biomarker for differentiating glioma from brain metastasis: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00330-018-5335-0" "Revista" => array:6 [ "tituloSerie" => "Eur Radiol" "fecha" => "2018" "volumen" => "28" "paginaInicial" => "3819" "paginaFinal" => "3831" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differentiation of solitary brain metastasis from glioblastoma multiforme: a predictive multiparametric approach using combined MR diffusion and perfusion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/S00234-015-1524-6" "Revista" => array:6 [ "tituloSerie" => "Neuroradiology" "fecha" => "2015" "volumen" => "57" "paginaInicial" => "697" "paginaFinal" => "703" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Single brain metastasis versus glioblastoma multiforme: a VOI-based multiparametric analysis for differential diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/S11547-022-01480-X" "Revista" => array:4 [ "tituloSerie" => "Radiol Med" "fecha" => "2022" "volumen" => "127" "paginaInicial" => "490" ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiol.2223010558" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "2002" "volumen" => "222" "paginaInicial" => "715" "paginaFinal" => "721" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiological progression of cerebral metastases after radiosurgery: assessment of perfusion MRI for differentiating between necrosis and recurrence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00415-009-5034-5" "Revista" => array:5 [ "tituloSerie" => "J Neurol" "fecha" => "2009" "volumen" => "256" "paginaInicial" => "878" "paginaFinal" => "887" ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical applications of magnetic resonance spectroscopy in brain tumors: from diagnosis to treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rcl.2021.01.004" "Revista" => array:6 [ "tituloSerie" => "Radiol Clin North Am" "fecha" => "2021" "volumen" => "59" "paginaInicial" => "349" "paginaFinal" => "362" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proton magnetic resonance spectroscopy in differentiating glioblastomas from primary cerebral lymphomas and brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RCT.0b013e3181ec554e" "Revista" => array:6 [ "tituloSerie" => "J Comput Assist Tomogr" "fecha" => "2010" "volumen" => "34" "paginaInicial" => "836" "paginaFinal" => "841" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-grade glioma and solitary metastasis: differentiation by spectroscopy and advanced magnetic resonance techniques" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s41984-022-00172-y" "Revista" => array:5 [ "tituloSerie" => "Egypt J Neurosurg" "fecha" => "2020" "volumen" => "222" "paginaInicial" => "715" "paginaFinal" => "721" ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of magnetic resonance spectroscopy for the differentiation of recurrent glioma from radiation necrosis: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejrad.2014.09.018" "Revista" => array:6 [ "tituloSerie" => "Eur J Radiol" "fecha" => "2014" "volumen" => "83" "paginaInicial" => "2181" "paginaFinal" => "2189" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed [18 F]-FDG PET imaging increases diagnostic performance and reproducibility to differentiate recurrence of brain metastases from radionecrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RLU.0000000000004305" "Revista" => array:6 [ "tituloSerie" => "Clin Nucl Med" "fecha" => "2022" "volumen" => "47" "paginaInicial" => "800" "paginaFinal" => "806" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic accuracy of amino acid and FDG-PET in differentiating brain metastasis recurrence from radionecrosis after radiotherapy: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3174/ajnr.A5472" "Revista" => array:6 [ "tituloSerie" => "Am J Neuroradiol" "fecha" => "2018" "volumen" => "39" "paginaInicial" => "280" "paginaFinal" => "288" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolic imaging of brain tumor recurrence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2214/AJR.19.22624" "Revista" => array:5 [ "tituloSerie" => "Am J Roentgenol" "fecha" => "2020" "volumen" => "215" "paginaInicial" => "1199" "paginaFinal" => "1207" ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What does PET imaging bring to neuro-oncology in 2022?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3390/cancers14040879" "Revista" => array:6 [ "tituloSerie" => "A Review" "fecha" => "2022" "volumen" => "10" "numero" => "14" "paginaInicial" => "879" "paginaFinal" => "896" ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular Imaging of Brain Metastases with PET" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.36255/exon-publications.metastasis" "LibroEditado" => array:5 [ "editores" => "C.M.Sergi" "titulo" => "Metastasis" "paginaInicial" => "1" "paginaFinal" => "16" "serieFecha" => "2022" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack738839" "titulo" => "Acknowledgements" "texto" => "<p id="par0235" class="elsevierStylePara elsevierViewall">Our sincere thanks to Julián Pérez-Beteta PhD (Mathematical Oncology Laboratory) and Pablo Cardinal MD, PhD, for their help in the statistical analysis of the doctoral thesis that sparked our interest in the radiological assessment of brain metastases.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21735107/0000006600000002/v1_202404120611/S2173510724000454/v1_202404120611/en/main.assets" "Apartado" => array:4 [ "identificador" => "45683" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Update in Radiology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735107/0000006600000002/v1_202404120611/S2173510724000454/v1_202404120611/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510724000454?idApp=UINPBA00004N" ]
