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array:22 [ "pii" => "S2173510714000561" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2014.05.007" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "747" "copyright" => "SERAM" "copyrightAnyo" => "2014" "documento" => "article" "subdocumento" => "fla" "cita" => "Radiologia. 2014;56:390-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2780 "formatos" => array:2 [ "HTML" => 2199 "PDF" => 581 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0033833814000952" "issn" => "00338338" "doi" => "10.1016/j.rx.2014.05.003" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "747" "copyright" => "SERAM" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Radiologia. 2014;56:390-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 8018 "formatos" => array:3 [ "EPUB" => 13 "HTML" => 5244 "PDF" => 2761 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Actualización</span>" "titulo" => "Mamografía con realce de contraste mediante técnica de energía dual" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "390" "paginaFinal" => "399" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Dual-energy contrast-enhanced mammography" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0040" "etiqueta" => "Figura 8" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr8.jpeg" "Alto" => 1000 "Ancho" => 754 "Tamanyo" => 49292 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Paciente de 70 años con carcinoma intraductal en la mama izquierda a la que se le diagnosticó una lesión sospechosa de malignidad en la mama contralateral (región retroareolar de la mama derecha), que resultó ser un fibroadenoma.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.M. Travieso Aja, M. Rodríguez Rodríguez, S. Alayón Hernández, V. Vega Benítez, O.P. Luzardo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M.M." "apellidos" => "Travieso Aja" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Rodríguez Rodríguez" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Alayón Hernández" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Vega Benítez" ] 4 => array:2 [ "nombre" => "O.P." "apellidos" => "Luzardo" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173510714000561" "doi" => "10.1016/j.rxeng.2014.05.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510714000561?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833814000952?idApp=UINPBA00004N" "url" => "/00338338/0000005600000005/v1_201410110204/S0033833814000952/v1_201410110204/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S217351071400055X" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2014.04.006" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "740" "copyright" => "SERAM" "documento" => "article" "subdocumento" => "fla" "cita" => "Radiologia. 2014;56:400-12" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3979 "formatos" => array:2 [ "HTML" => 3551 "PDF" => 428 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Update in Radiology</span>" "titulo" => "Perineural spread in head and neck tumors" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "400" "paginaFinal" => "412" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Diseminación perineural en tumores de cabeza y cuello" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1635 "Ancho" => 2176 "Tamanyo" => 397450 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Anatomopathological cut. Nerve fasciculus made up of several nerve fibers and the endoneurium surrounded by the perineurium. In this case there was perineural affectation due to tumor cells (arrow points) that completely surrounded the nerve circumference. (B) Diagram of peripheral nerve.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. Brea Álvarez, M. Tuñón Gómez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "B." "apellidos" => "Brea Álvarez" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Tuñón Gómez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0033833814000666" "doi" => "10.1016/j.rx.2014.04.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833814000666?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217351071400055X?idApp=UINPBA00004N" "url" => "/21735107/0000005600000005/v1_201411230009/S217351071400055X/v1_201411230009/en/main.assets" ] "en" => array:21 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Update in Radiology</span>" "titulo" => "Dual-energy contrast-enhanced mammography" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "390" "paginaFinal" => "399" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.M. Travieso Aja, M. Rodríguez Rodríguez, S. Alayón Hernández, V. Vega Benítez, O.P. Luzardo" "autores" => array:5 [ 0 => array:4 [ "nombre" => "M.M." "apellidos" => "Travieso Aja" "email" => array:2 [ 0 => "operez@dcc.ulpgc.es" 1 => "marimartravieso@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Rodríguez Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Alayón Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "V." "apellidos" => "Vega Benítez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "O.P." "apellidos" => "Luzardo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Diagnóstico por Imagen, Grupo Hospitalario San Roque, Las Palmas de Gran Canaria, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía, Complejo Hospitalario Universitario Insular-Materno Infantil (CHUIMI), Las Palmas de Gran Canaria, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Ciencias Clínicas, Facultad de Ciencias de la Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Mamografía con realce de contraste mediante técnica de energía dual" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0050" "etiqueta" => "Figure 10" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr10.jpeg" "Alto" => 973 "Ancho" => 1299 "Tamanyo" => 113691 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">CESM study showing several diffuse and bilateral multiple uptakes not easy to interpret in one patient with high breast density (BI-RADS 3). (A) Cranial-caudal view of her right breast; (B) cranial-caudal view of her left breast.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">It is well known that tumor cells are metabolically very active and require a great deal of nutrients which in their growth causes a process known as angiogenesis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Its clinical importance has been established for breast cancer since it is an independent prognostic factor highly associated with the incidence of metastasis.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Since they are very rapidly forming micro-vessels, porosity is high and when injecting IV contrast media, they spread the interstitial liquid of tumor mass they enhance.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This is why since the 1980s different modalities have been born whose goal is to explore tumor angiogenesis by using contrast media like breast angiography,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> CT<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and magnetic resonance (MR).<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The MR is the most widely used modality and the most important one clinical-wise since it is the most sensitive image diagnostic modality for the detection and study of breast cancer. However, the MR has several drawbacks mainly due to its high cost and also to its limitation in claustrophobic excessively obese patients or with a certain type of extra-breast prostheses, pacemakers or foreign bodies among others. This is why numerous patients cannot have access to it.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">With the arrival of the new millennium digital radiology has gained momentum and it is full of advantages.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> One of the main ones is that it allows us to post-process images with computer applications aimed at improving diagnosis.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,7</span></a> One of these computer apps is iodinated contrast enhanced digital mammography. Several studies have proven that it is a cheaper alternative than MR.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,9–12</span></a> It is also an alternative to conventional mammography in order to avoid unnecessary biopsies<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> also and adjunct modality to conventional mammography and ultrasound in order to improve the diagnosis of malignant lesions,<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,9–12</span></a> and even better than MR for diagnosis.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> However, this modality is still recent and no author has clearly established what role it plays in the diagnostic algorithm of breast disease.</p><p id="par0015" class="elsevierStylePara elsevierViewall">During these years this technique has been developing parallel in two modalities. The first one, more like conventional angiography, is called temporal contrast-enhanced mammography (TCEM). The other one, based on image-acquisition at different energies, is called contrast-enhanced spectral mammography (CESM) (also called dual energy mammography). In both cases we must inject the patient an IV iodinated contrast media through an automatic injector to secure constant flow. During these first ten years of life several studies showing that both modalities are promising have been done since they improve both the specificity and sensibility to diagnose breast lesions. Nonetheless results indicate that TCEM has some important technical limitations still not worked out while the clinical performance of CESM can be improved. In this article we mainly deal with the dual energy modality but in the following segment we will discuss the main features, advantages and limitations of TCEM.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Temporal contrast-enhanced mammography</span><p id="par0020" class="elsevierStylePara elsevierViewall">The main feature of this modality is that other than enhancing the images of those contrast media uptaking-lesions, it also gets information on the temporary pattern of uptake and further iodinated contrast clearance. This is why it is the most similar of the two to the MRI. Although there is some controversy about it, the information delivered by the uptake curves of breast lesions can be very relevant since it seems that the more slowly uptaking-lesions are usually benign while a fast pattern in the uptake is associated with a greater degree of malignancy.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> To be able to use this pattern through digital mammography different images are taken in various moments. In the first place one image before injecting the contrast media with the compressed breast (“mask”) needs to be taken. Then while compressing the breast the contrast media is injected and sequential images are acquired (usually one image per minute) during a different time frame (4–10<span class="elsevierStyleHsp" style=""></span>min) depending on the pattern we want to explore (uptake or uptake<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>clearance). To improve the view of the lesions the “mask” is subtracted from the images acquired through the contrast agent.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,7,14</span></a> One of the main limitations is that patients cannot tolerate so much time of compression (up to 15<span class="elsevierStyleHsp" style=""></span>min),<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> so there are usually numerous movement artifacts that makes images unable to be fully overlapping. This is why we need specific software to compensate all distortions caused by movement. Another important limitation is that with this modality we can study one breast and with one view only and that limits the confirmation of lesions previously diagnosed clinically or radiologically. If we want to study both breasts as we usually do through conventional mammography both the times and contrast doses will multiply by the number of views we want. This is why even though the dose of radiation needed to obtain each individual image is similar to that of routine mammographies (1–3<span class="elsevierStyleHsp" style=""></span>mGy),<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> the total dose will depend on the number of images obtained. Several studies done so far show that when artifact-free images are obtained the TCEM is way more sensitive and specific than conventional mammographies to diagnose cancer.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,10,11,15</span></a> However, the main theoretical advantage of this modality with respect to CESM—that is the study of the uptake/clearance pattern does not seem as closely associated as MRI with malignancies/benignities of lesions.</p><p id="par0025" class="elsevierStylePara elsevierViewall">As a matter of fact in one recent investigation the gradual uptake of contrast was very common in 20 malignant lesions studied (80%).<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">16</span></a> This was attributed to the fact that breast compression probably altered the pattern of local circulation of the breast during the study. For all these reasons at least up to now CESM is being more widely accepted than TCEM in radiology units since its diagnostic power is similar and it is faster, easier to do and is way more tolerated. In <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> we show a comparison between the features of both modalities of digital contrast enhanced-mammographies. In <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> we show a summary of the main investigational studies used to evaluate the clinical performance of digital contrast enhanced-mammographies (both TCEM and CESM).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Contrast-enhanced spectral mammography</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Features</span><p id="par0030" class="elsevierStylePara elsevierViewall">This modality is based on the attenuation of radiation when it goes through different materials, in this case iodine and soft tissues. Hence, after injecting iodinated contrast the usual mammographic views are done with the difference being that two consecutives images are acquired for each view: one of low energy and the other one of high energy. The criteria used to select the range of kVp and mAs for each image are defined in Ref. <a class="elsevierStyleCrossRef" href="#bib0120">17</a>. For the high energy-image adapting the digital mammography is required since we need a breast compression system modified to allow the use of an additional filter.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Low energy-images are obtained through technical exposure similar to that of conventional mammographies (26–31<span class="elsevierStyleHsp" style=""></span>kVp). This is how even iodine cannot be seen; it is already present since the kilovoltage is well below the iodine energy K-absorption edge (33.2<span class="elsevierStyleHsp" style=""></span>kVp).<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Immediately after this the second image of the breast is automatically acquired with a 45–49<span class="elsevierStyleHsp" style=""></span>kVp kilovoltage that because it is above the iodine energy K-absorption edge it obtains information from the lesion on contrast uptake. For low energy exposure anodus, molibdenus (Mo) or rodius (Rh) filters should be used and for high energy exposure aluminum or copper filters which allow the absorption of soft unnecessary radiation and preservation of photons around the iodine absorption energy. Postprocessing allows us to obtain one combined image where contrast uptake-areas are enhanced and the normal tissue areas suppressed.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Up to now one computer program is available for commercial purposes to combine different images (Senobright<span class="elsevierStyleSup">®</span>, General Electric Healthcare™, Buckinghamshire, United Kingdom) that limit the implementation of this modality to many radiology units.</p><p id="par0040" class="elsevierStylePara elsevierViewall">In sum, in around 7<span class="elsevierStyleHsp" style=""></span>min a combination of low and high energy-images is acquired through breast and views (cranial caudal and media-lateral-oblique views). This is how in the same process we acquire both the conventional image of mammography (obtained at low energy) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and the combined image (after applying the subtraction algorithm) which will allow us to view uptake areas only (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). In the CESM the movement artifact is not a problem and the patient can tolerate it very well (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>) while both breasts can be studied in the same proceeding and with one contrast injection only. However, the CESM does not allow us to study the uptake and clearance pattern and it is estimated that the overall average radiation dose is 20–54% greater than the dose of one routine view of a digital mammography.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,14</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The main clinical studies have compared the diagnosis of malignant breast lesions through CESM and conventional digital mammography alone and in combination with breast ultrasound.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> These studies showed that CESM was superior for the diagnosis of malignant lesions (93% and 78%), and also superior for the diagnosis of additional malignant lesions (sensibility) without increasing the number of false positives (specificity). According to these studies both the sensibility and specificity of CESM for the diagnosis of malignant lesions would be equivalent to that of conventional mammographies and ultrasounds combined. As a matter of fact with one experienced radiologist the diagnostic capacity of CESM can be up to 40% greater than conventional mammographies and ultrasounds combined.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">CESM and MRI can be considered equivalent for the detection of primary tumors while for the detecting of additional lesions MRI are superior.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> However, the number of false positives of MRI was greater (greater specificity of CESM) and the predictive value for carcinomas was significantly greater with CESM (97% and 85%). Also, CESM can be better than MRI to estimate the size and stratify tumors.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> we show the main pros and cons of CESM today.</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Examination protocol</span><p id="par0060" class="elsevierStylePara elsevierViewall">The necessary material is an automatic contrast injection pump, one digital mammography kit equipped with a breast compression system with aluminum or copper filters and a working station with the application Senobright<span class="elsevierStyleSup">®</span> (General Electric Healthcare™, Buckinghamshire, United Kingdom). When it comes to human resources we need one nurse for the IV injection and monitoring during the whole process and one expert technician in radiodiagnostics who has experience in mammographies. The physical presence of a radiologist is not necessary. The informed consent from the patient is necessary so that we know if she has prior known allergies to contrast agents or renal disease counter-indicated by the study and we will proceed as in other radiological modalities using IV iodinated contrast. It will also explain what dose of radiation can the patient receive being patients who might be pregnant totally discarded.</p><p id="par0065" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a> we can see the steps to follow during a CESM study. Once the patient is seated and preferably relaxed iodinated contrast is administered (1.5<span class="elsevierStyleHsp" style=""></span>mg/kg iv, at 3<span class="elsevierStyleHsp" style=""></span>ml/s). Two minutes after the injection the acquisition of images begins following a process involving a fewer mammograph manipulations for the patient's convenience. In our unit we are starting to study the unsuspicious breast through and in this order mediolateral oblique and cranial-caudal views. Then the abnormal breast in inverse order is studied. Even though order does not seem to influence the final result of the study,<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,14</span></a> it is recommended that once the protocol to be followed has been established such protocol will not be altered. The acquisition of all images is done in 5<span class="elsevierStyleHsp" style=""></span>min tops.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">In our service we began with CESM back in January 2013 and ever since then we have studied 136 patients (average age 49.1 years; age range 32–83 years). Most patients were studied due to previous suspicion (67%), routine mammographic monitoring (22%) and due the impossibility of doing MRI (7%), and also to monitor the response to neoadjuvant therapy (4%). With this modality we have studied 187 lesions in total (114 malignant and 73 benign).</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Main clinical applications</span><p id="par0225" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">–</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Diagnosis of palpable lesions</span>. Given CESM also includes one image equivalent to conventional mammography it has the same clinical applications with the additional advantage that the combined image can make the diagnostic power be similar to that of the combined used of mammography<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ultrasound<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">–</span><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Diagnosis of lesions lowly suspicious for malignancy</span>. When signs at the conventional mammography or ultrasound are not conclusive the European Society of Breast Imaging claims that due to its high negative predictive value MRI allow us to almost completely discard breast cancer.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Studies done so far have proven that the performance of CESM is similar to that of MRI in these cases,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> yet the series of patients are still relatively small (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">–</span><p id="par0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Complementary study of recently diagnosed-malignant lesions</span>. When breast cancer is clinical or radiologically diagnosed the CESM can be very useful to find multicentric, multifocal, and contralateral lesions that can usually be seen in combined images but that are not so evident in conventional mammographies. Similarly CESM can help in the ultrasound of multiple lesions to decide which ones require biopsy<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">–</span><p id="par0095" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Assessment of the response to neoadjuvant chemotherapy and post-operative follow-up.</span> CESM is potentially a good substitute for MRI in the assessment of the response to neoadjuvant chemotherapy,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,13</span></a> yet we still need solid studies to prove it scientifically (<a class="elsevierStyleCrossRef" href="#fig0030">Fig. 6</a>). On the other hand, the CESM is also a potentially useful modality to distinguish between post-operative breast remodeling and cancer relapse since it allows us to distinguish between the fibrotic tissue—not highly vascularized and tumor neoforming whose contrast uptake-enhancement is equivalent to that of MRI.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">–</span><p id="par0100" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Patients not eligible for MRI studies.</span> CESM is a good substitute for MRI when this modality is relative or absolutely counter-indicated or in the presence of physical limitations.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p></li></ul></p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Main limitations of the contrast-enhanced spectral mammography</span><p id="par0230" class="elsevierStylePara elsevierViewall">– <span class="elsevierStyleItalic">False negatives.</span> Yet, despite the fact that in the clinical studies done so far the percentage of false negatives has been really low, some of them have been associated with poorly vascularized tumors. It also has some diagnostic limitations in deep or axillary tumors and even though clinical performance is better than that of conventional mammography in these cases, the ultrasound is also recommended as an adjunctive modality.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Its limitations with malignant microcalcifications with no underlying mass<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> have also been reported. As a matter of fact our false negatives have been associated with this; they can be seen in low energy images but not in the combined image. In these cases the result of biopsy was malignancy (<a class="elsevierStyleCrossRef" href="#fig0035">Fig. 7</a>). Even though some studies of this sort have precluded them,<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> we have studied them because the low energy image gives us information and sometimes the combined image shows uptake areas.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> This shows that longer series of patients are still necessary to be able to categorically say that this is an absolute limitation.</p><elsevierMultimedia ident="fig0035"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">– <span class="elsevierStyleItalic">False positives.</span> In our patients we also found an intense uptake patter in the case of two benign lesions (fibroadenomes) (<a class="elsevierStyleCrossRef" href="#fig0040">Fig. 8</a>) of an overall 114 lesions (1.7%), a number that is lower to that of our MRI studies. Similar percentages have been published by other authors.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> However, there are not enough publications yet to be able to conclusively determine the real percentage of CESM false positives.</p><elsevierMultimedia ident="fig0040"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">– <span class="elsevierStyleItalic">Other limitations.</span> In our own experience siliconomes through direct injection in the breast of liquid silicone is one important limitation (<a class="elsevierStyleCrossRef" href="#fig0045">Fig. 9</a>A). Even though the effect of these implants is not reviewed in the reference in our unit, we see them often. Due to the features of this material the CESM combined image used with diagnostic purposes is completely useless. Nevertheless, other image diagnostic modalities are not useful in these cases either. On the other hand, patients with silicone surgical implants are usually tagged as not eligible for CESM diagnosis (verbal communication from General Electric Healthcare™). In the 8 patients studied in our unit we could only diagnose cancer through CESM in 50% of all cases (<a class="elsevierStyleCrossRef" href="#fig0045">Fig. 9</a>B).</p><elsevierMultimedia ident="fig0045"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Another limitation is the interpretation of ganglions and adenopathies since most do not have specific features to distinguish benignity from malignancy. However, this also happens with breast MRIs.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Lastly, probably due to the limited experience with this modality and also the limited literature about it we still often find uptake patters in combined images that are not easy to explain and interpret and that can be justified by the patient's moment of hormonal cycle and breast pattern (<a class="elsevierStyleCrossRef" href="#fig0050">Fig. 10</a>). No doubt we need longer series of patients and more cases in order to be able to assess correctly the clinical performance of this modality in the overall spectrum of breast disease.</p><elsevierMultimedia ident="fig0050"></elsevierMultimedia></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="par0140" class="elsevierStylePara elsevierViewall">CESM is at the same time a routine mammographic study and the contrasted image capable of finding angiogenesis. It is faster, easier to do and uses reproducible modality that is also easier to interpret. It is well tolerated by patients and its overlappable signs are similar to those of the MRI with the advantages that it is cheaper and it can be performed in patients in which MRIs are counter-indicated. It also allows us to do a correct diagnosis of multifocal, multicentric and bilateral affectation and a precise monitoring of the response to neoadjuvant chemotherapic therapy. Since both breasts with the same dose of contrast and proceeding are studied it can be recommended as first line diagnostic image—above all in high-risk patients. In any case it is interesting as a complementary test to mammographies and ultrasounds in all patients. However, experience is still limited and we need further studies with larger series of patients to be able to establish correctly both the clinical performance and the sensibility and specificity of this new modality.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Ethical responsibilities</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Protection of people and animals</span><p id="par0145" class="elsevierStylePara elsevierViewall">Authors confirm that no experiments have been performed on human beings or animals.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Data confidentiality</span><p id="par0150" class="elsevierStylePara elsevierViewall">Authors confirm that the protocols of their centers have been followed on matters concerning the publishing of data from patients. They also confirm that all patients included in this study have been given enough information and handed over their written informed consent for their participation in this study.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Right to privacy and informed consent</span><p id="par0155" class="elsevierStylePara elsevierViewall">Authors confirm that they have obtained the written informed prior consent from patients and/or subjects appearing in this article. This document is in the possession of the corresponding author.</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Authors</span><p id="par0160" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">1.</span><p id="par0165" class="elsevierStylePara elsevierViewall">Manager of the integrity of the study: MMTA.</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">2.</span><p id="par0170" class="elsevierStylePara elsevierViewall">Original idea of the study: MMTA, OPL, MRR, SAH, VVB.</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">3.</span><p id="par0175" class="elsevierStylePara elsevierViewall">Study design: MMTA, OPL, MRR, SAH, VVB.</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">4.</span><p id="par0180" class="elsevierStylePara elsevierViewall">Data mining: MMTA, SAH, MRR.</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">5.</span><p id="par0185" class="elsevierStylePara elsevierViewall">Data analysis and interpretation: MMTA, SAH, MRR, VVB, OPL.</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">6.</span><p id="par0190" class="elsevierStylePara elsevierViewall">Statistical analysis: N/A</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">7.</span><p id="par0195" class="elsevierStylePara elsevierViewall">Reference search: MMTA, VVB, OPL.</p></li><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">8.</span><p id="par0200" class="elsevierStylePara elsevierViewall">Writing: MMTA, OPL.</p></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">9.</span><p id="par0205" class="elsevierStylePara elsevierViewall">Manuscript critical review with intellectually relevant contributions: MMTA, OPL, MRR, SAH, VVB.</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">10.</span><p id="par0210" class="elsevierStylePara elsevierViewall">Final version approval: MMTA, OPL, MRR, SAH, VVB.</p></li></ul></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors reported that they have no conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:2 [ "identificador" => "xres384941" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec363757" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres384940" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec363758" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Temporal contrast-enhanced mammography" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Contrast-enhanced spectral mammography" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Features" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Examination protocol" ] 2 => array:2 [ "identificador" => "sec0065" "titulo" => "Main clinical applications" ] 3 => array:2 [ "identificador" => "sec0070" "titulo" => "Main limitations of the contrast-enhanced spectral mammography" ] ] ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Conclusions" ] 8 => array:3 [ "identificador" => "sec0035" "titulo" => "Ethical responsibilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Protection of people and animals" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Data confidentiality" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0055" "titulo" => "Authors" ] 10 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflict of interests" ] 11 => array:2 [ "identificador" => "xack104581" "titulo" => "Acknowledgement" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-03-15" "fechaAceptado" => "2014-05-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec363757" "palabras" => array:8 [ 0 => "Spectral mammography" 1 => "Dual energy" 2 => "Contrast-enhanced mammography" 3 => "Breast disease" 4 => "Breast cancer" 5 => "Iodinated contrast agents" 6 => "Contrast-enhanced spectral mammography" 7 => "Review" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec363758" "palabras" => array:8 [ 0 => "Mamografía espectral" 1 => "Energía dual" 2 => "Mamografía con contraste" 3 => "Patología mamaria" 4 => "Cáncer de mama" 5 => "Contraste yodado" 6 => "Mamografía con realce de contraste espectral" 7 => "Revisión" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The degree of vascularization in breast lesions is related to their malignancy. For this reason, functional diagnostic imaging techniques have become important in recent years. Dual-energy contrast-enhanced mammography is a new, apparently promising technique in breast cancer that provides information about the degree of vascularization of the lesion in addition to the morphological information provided by conventional mammography. This article describes the state of the art for dual-energy contrast-enhanced mammography. Based on 15 months’ clinical experience, we illustrate this review with clinical cases that allow us to discuss the advantages and limitations of this technique.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Es bien conocido que el grado de vascularización de las lesiones mamarias se relaciona con su malignidad. Por ello, las técnicas de diagnóstico por imagen que estudian funcionalmente las lesiones han cobrado mucha relevancia en los últimos años. La mamografía con medio de contraste y energía dual es una técnica de reciente aparición, aparentemente prometedora en el cáncer de mama, que informa del grado de vascularización de la lesión junto con la información morfológica habitual. El propósito de este artículo es presentar el estado actual de esta nueva técnica de imagen. Basándonos en una experiencia de 15 meses, ilustramos esta revisión con casos clínicos que nos permiten presentar también sus ventajas y limitaciones.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Travieso Aja MM, Rodríguez Rodríguez M, Alayón Hernández S, Vega Benítez V, Luzardo OP. Mamografía con realce de contraste mediante técnica de energía dual. Radiología. 2014;56:390–399.</p>" ] ] "multimedia" => array:13 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 669 "Ancho" => 1000 "Tamanyo" => 65284 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Image equivalent to conventional mammography acquired at low energy and (B) image combined after applying the subtraction algorithm showing lesion enhancement uptaking the iodinated contrast (B).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2336 "Ancho" => 3292 "Tamanyo" => 360189 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">CESM exam protocol. Two minutes after injecting the IV contrast media low and high energy images are acquired following this order: (a) medial–lateral oblique view—non-suspicious breast; (b) cranial–caudal view—non-suspicious breast; (c) cranial–caudal view—suspicious breast; (d) medial–lateral oblique view—suspicious breast.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 697 "Ancho" => 1900 "Tamanyo" => 119454 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(A) Palpable lesion in the superior external quadrant of her left breast corresponding to a suspicious solid lesion in the ultrasound. (B) Low energy-CESM and (C) combined in which a lesion with uptake in the irregular thick ring can be seen—suspicious for malignancy. Final outcome: colloid carcinoma. In the breast we can see one percutaneous marker since CESM was done once the patient was diagnosed.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 880 "Ancho" => 1300 "Tamanyo" => 111669 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Patient with suspicious focal asymmetry in the superior external quadrant of the right breast in the low energy-image (A) without uptake in the combined image (B).</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 958 "Ancho" => 1000 "Tamanyo" => 100922 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Patient with extensive comedocarcinoma-like subtype intraductal carcinoma. (A) Low energy image and (B) combined image CESM is performed. Multifocal affectation that CESM allowed to delineate with greater accuracy through ultrasound-directed biopsy.</p>" ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 818 "Ancho" => 1000 "Tamanyo" => 125594 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Patient with neoadjuvant therapy of infiltrating ductal carcinoma. CESM combined image (A) before and (B) after finishing chemotherapy. Complete remission. MRI and CESM can be overlapped. No enhancement.</p>" ] ] 6 => array:7 [ "identificador" => "fig0035" "etiqueta" => "Figure 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 723 "Ancho" => 1330 "Tamanyo" => 117038 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Patient with malignant micro-calcifications in the inferior internal quadrant of her right breast also showing several nodes in the large area of micro-calcifications. (A) Low energy-image and (B) combined in which only the area that coincides with the underlying mass is enhanced. The intermediate area without any findings in the ultrasound does not show uptake. Final outcome: infiltrating intraductal carcinoma.</p>" ] ] 7 => array:7 [ "identificador" => "fig0040" "etiqueta" => "Figure 8" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr8.jpeg" "Alto" => 1000 "Ancho" => 754 "Tamanyo" => 49292 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Seventy-year-old patient with intraductal carcinoma in her left breast diagnosed with a lesion suspicious for malignancy in the contralateral breast (retroareolar region of her right breast) eventually resulting into fibroadenoma.</p>" ] ] 8 => array:7 [ "identificador" => "fig0045" "etiqueta" => "Figure 9" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr9.jpeg" "Alto" => 894 "Ancho" => 1400 "Tamanyo" => 136579 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">(A) Fifty-year-old patient with siliconomes due to the injection of liquid silicone in both breasts. Cranial-caudal view combined image of her left breast. (B) Forty-one-year-old patient diagnosed with CESM due to lobular carcinoma in the presence of breast prosthetic implants.</p>" ] ] 9 => array:7 [ "identificador" => "fig0050" "etiqueta" => "Figure 10" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr10.jpeg" "Alto" => 973 "Ancho" => 1299 "Tamanyo" => 113691 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">CESM study showing several diffuse and bilateral multiple uptakes not easy to interpret in one patient with high breast density (BI-RADS 3). (A) Cranial-caudal view of her right breast; (B) cranial-caudal view of her left breast.</p>" ] ] 10 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">CESM: contrast-enhanced spectral mammography (or dual energy); TCEM: temporal contrast-enhanced mammography.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TCEM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CESM \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Duration of study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15<span class="elsevierStyleHsp" style=""></span>min \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7<span class="elsevierStyleHsp" style=""></span>min \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Compression \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">From the beginning \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>min after the administration of contrast \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mask \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Necessary \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not necessary \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Study range \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One breast-one view \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Two breasts-two views ea \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patient tolerance \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Poor \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Good \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reported information \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">We acquire the contrasted image and clearance and uptake curves \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">We acquire the routine mammographic diagnosis and the contrasted image. No acquisition of clearance/uptake curves \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Prior diagnostic suspicion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Radiation received \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Equivalent to that of conventional mammography based on the views obtained \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20–50% greater than that of conventional mammography \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Artifacts \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Many (movement) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Few \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab588726.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Comparison of the features of TCEM and CESM.</p>" ] ] 11 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">CESM: contrast-enhanced spectral mammography (or dual energy); TCEM: temporal contrast-enhanced mammography.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Authors and reference \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Year \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Type of lesions \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">TCEM</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Jong et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 benign, 10 malignant \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dromain et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">All malignant \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diekmann et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2011 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 benign, 30 malignant \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">CESM</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lewin et al.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 benign, 10 malignant \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dromain et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2011 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62 benign, 80 malignant \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dromain et al.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">110 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54 benign, 84 malignant \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Jochelson et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2013 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">All malignant \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fallenberg et al.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2013 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">All malignant \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab588728.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Summary of the main studies done for the assessment of clinical performance of contrast-enhanced digital mammography.</p>" ] ] 12 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">CESM: contrast-enhanced spectral mammography (or dual energy).</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Pros \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Cons \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fast (7<span class="elsevierStyleHsp" style=""></span>min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Greater dose of radiation than conventional mammography (20–50%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Easy to do \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fasting required (it needs to be planned) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Easy to read \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non eligible for patients allergic to iodine without premedication \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cost-effective (compared to MRI), though it results in 20% more expenses than conventional mammographies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non eligible for patients with renal failure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Well tolerated by all patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Some cases of allergic reactions have been reported \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">It results in the acquisition—in the same process of the routine study and contrast image \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Today one company owns the patent of the needed software only \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">It studies both breasts in the same process \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lesser degree of diagonstic performance in breast prostheses \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Eligible for patients carrying pacemakers and metallic materials \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non eligible to study siliconomes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Eligible in claustrophobic patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Few clinical studies today \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab588727.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Main 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