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array:23 [ "pii" => "S2173510717300514" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2017.07.002" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "974" "copyright" => "SERAM" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2017;59:523-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1 "PDF" => 1 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S003383381730070X" "issn" => "00338338" "doi" => "10.1016/j.rx.2017.04.008" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "974" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2017;59:523-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 513 "formatos" => array:2 [ "HTML" => 185 "PDF" => 328 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Cicatriz radial sin atipia en biopsia percutánea. ¿Puede evitarse la biopsia quirúrgica?" 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Mesa-Quesada, S. Romero-Martín, M. Cara-García, A. Martínez-López, M. Medina-Pérez, J.L. Raya-Povedano" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Mesa-Quesada" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Romero-Martín" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Cara-García" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Martínez-López" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Medina-Pérez" ] 5 => array:2 [ "nombre" => "J.L." "apellidos" => "Raya-Povedano" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173510717300514" "doi" => "10.1016/j.rxeng.2017.07.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510717300514?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S003383381730070X?idApp=UINPBA00004N" "url" => "/00338338/0000005900000006/v1_201711120018/S003383381730070X/v1_201711120018/es/main.assets" ] ] "itemAnterior" => array:19 [ "pii" => "S2173510717300654" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2017.10.002" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "984" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2017;59:516-22" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2 "HTML" => 2 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Report</span>" "titulo" => "Value of intraoperative ultrasound with conventional probes and its usefulness in surgical and therapeutic management of patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "516" "paginaFinal" => "522" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Valor de la ecografía intraoperatoria realizada con sondas convencionales y su utilidad en el manejo quirúrgico y terapéutico de los pacientes" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2234 "Ancho" => 1645 "Tamanyo" => 114108 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Bar graph showing the matches between the intraoperative ultrasound scan and the histological findings, and pie chart showing the matches between the intraoperative ultrasound scan and the preoperative imaging modalities.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.M. Novo Amado, M. Fraga Sánchez, J. González Ramírez, G. Calvo Arrojo, C. Vidal Cameán, J.M. Crespo Teijeiro" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A.M." "apellidos" => "Novo Amado" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Fraga Sánchez" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "González Ramírez" ] 3 => array:2 [ "nombre" => "G." "apellidos" => "Calvo Arrojo" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Vidal Cameán" ] 5 => array:2 [ "nombre" => "J.M." "apellidos" => "Crespo Teijeiro" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0033833817301029" "doi" => "10.1016/j.rx.2017.06.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833817301029?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510717300654?idApp=UINPBA00004N" "url" => "/21735107/0000005900000006/v1_201711202321/S2173510717300654/v1_201711202321/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Radial scars without atypia in percutaneous biopsy specimens: Can they obviate surgical biopsy?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "523" "paginaFinal" => "530" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Mesa-Quesada, S. Romero-Martín, M. Cara-García, A. Martínez-López, M. Medina-Pérez, J.L. Raya-Povedano" "autores" => array:6 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Mesa-Quesada" "email" => array:1 [ 0 => "juanmeque@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "S." "apellidos" => "Romero-Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Cara-García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Martínez-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "M." "apellidos" => "Medina-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "J.L." "apellidos" => "Raya-Povedano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Sección de Radiología de mama (UGC Radiodiagnóstico y cáncer de mama), Hospital Universitario Reina Sofía, Córdoba, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "UGC de Anatomía Patológica, Hospital Universitario Reina Sofía, Córdoba, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cicatriz radial sin atipia en biopsia percutánea. ¿Puede evitarse la biopsia quirúrgica?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2579 "Ancho" => 2214 "Tamanyo" => 208054 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Types of percutaneous biopsied performed, and management of patients with radial scar without atypia. CNB: core needle biopsy; VAB: vacuum-assisted biopsy.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The radial scar (RS) is a histological entity characterized by one fiber-elastic center continuing glandular elements from which ductal and lobular structures in a “starry sky” configuration irradiate.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1–3</span></a> Sizes >1<span class="elsevierStyleHsp" style=""></span>cm are called “complex sclerosing lesions”,<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">2</span></a> although this term and the term radial scar are used interchangeably.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The radiological appearance of RS is undistinguishable from invasive carcinomas.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">4</span></a> When it is seen in the mammogram, it is common to see a distortion of the architecture (radiolucent core and spiculae irradiating from this core and towards the periphery).<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">5</span></a> However, it may also appear as nodules, microcalcifications, or focal asymmetries.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">6</span></a> Its prevalence is around 2 per cent in the percutaneous biopsies performed to non-palpable lesions.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Benign breast lesions may be categorized into: non-proliferative, proliferative without atypia, and proliferative with atypia. RS may be associated with proliferative lesions without atypia, and proliferative lesions with atypia, cancer.<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">8,9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The increased risk of cancer in proliferative lesions with atypia has been well documented in numerous studies, up to 4.4 times higher than that of the general population.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1,10</span></a> Quantifying the risk of breast cancer in proliferative lesions without atypia is a common issue, which is why the management of patients diagnosed with RS without atypia through a percutaneous biopsy is still controversial.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">6</span></a> Some authors believe that it is a benign lesion with no risk of malignant transformation,<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">3,11,12</span></a> while others believe that it is a pre-malignant lesion precursor of breast cancer.<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">13,14</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The usual management of RS without atypia diagnosed through a percutaneous biopsy has been the surgical biopsy for some time now.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">4,5,15,16</span></a> However, recent evidence suggests that surgical resection is not necessary if the RS does not associate epithelial atypia.<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">17,18</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The main goal of this study is to assess the need for surgical biopsy after the diagnosis of RS without atypia through a percutaneous biopsy, in order to be able to determine if the surgical intervention may be avoided.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">We conducted one retrospective observational trial after obtaining the approval from our center ethics committee. We selected those patients whose anatomopathological report of the percutaneous biopsies performed showed radial scars, sclerosing radial lesions, or complex sclerosing lesions in order to identify cases of RS during a period of 8 years (from 2005 through 2012). The main statistical analysis was performed with the group of patients without atypia. Patients with signs of malignancy and atypia only, and patients without atypia were included in the study while conducting the concordance analyses and diagnostic indices.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Patients diagnosed with RS through the percutaneous biopsy, and those who did not undergo surgical biopsies, or were not followed were excluded.</p><p id="par0045" class="elsevierStylePara elsevierViewall">All those mammographic findings based on the Breast Imaging Reporting and Data System (BIRADS) – 5th edition<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">19</span></a> in nodules, architectural distortion, focal asymmetry, or microcalcifications were assessed.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The percutaneous biopsy was performed while guided by an ultrasound or stereotaxy and depending on the visibility of the lesion and preference of the radiologist. During the first years, the core needle biopsy (CNB) (Acecut biopsy needle, TSK, Japan) was used, but it would be substituted by the vacuum-assisted biopsy (VAB) with one 9 or 10G needle (Mammotome, stereotactic guided breast biopsy system Eviva, Hologic, UK and Stereotactic/Ultrasound Encor Probe, SenoRx Inc., USA). The percutaneous biopsy used to be repeated in the absence of concordance between the radiological and histological findings, or if the pathologist recommended taking more samples. The minimum experience of the radiologists and pathologists who participated in the study was 10 years.</p><p id="par0055" class="elsevierStylePara elsevierViewall">In the case of ultrasound-guided biopsies, there was not such a thing as a standard number of samples, and the final amount depended on the radiologist who performed it (between 3 and 6). In the stereotaxy-guided VAB, the minimum quantity was 12.</p><p id="par0060" class="elsevierStylePara elsevierViewall">All patients with cancer diagnosed by the percutaneous biopsy received therapy. Surgical biopsies were recommended to patients who underwent percutaneous biopsies before 2006 and whose results were RS with or without atypia, because it was the recommended practice at the time. From 2006 through 2012, the common practice was performing one VAB if the CNB findings were RS. The surgical biopsy was only performed in the presence of atypia, or in the absence of concordance between the radiological findings and the anatomopathological findings.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Patients who did not undergo surgical biopsies underwent clinical-radiological follow-up. At least during the first two years, the very first follow-up after the biopsy was conducted after 6 months, and then followed by annual controls. In the remaining cases, follow-up was annual.</p><p id="par0070" class="elsevierStylePara elsevierViewall">The data collected for the study were: age of the patient, type of lesion, size of the lesion, method of percutaneous biopsy used, if needed method of second percutaneous biopsy used, follow-up time of those patients who did not undergo surgical biopsies, and anatomopathology of the percutaneous biopsies and the surgical biopsy. We included the variable of presence of cancer, or not, as definitive diagnosis, with the understanding that it was definitive as long as the patients showed cancer in the surgical biopsy or at some point during follow-up. These data were collected retrospectively using the computing system of radiological reports (PDI), the imaging storage server (PACS, Carestream), and our hospital system for the management of anatomopathological reports.</p><p id="par0075" class="elsevierStylePara elsevierViewall">The statistical analysis was conducted using the IBM SPSS software (version 10.0). We conducted descriptive studies of patients with RS and without atypia. We assessed the differences among the different variables between the follow-up groups and the surgical biopsy group (chi square statistic test, Fisher's exact test, or Student's <span class="elsevierStyleItalic">t</span> test). The underestimation rate of the percutaneous biopsy in both groups was assessed (Fisher's exact test). We defined underestimation as a benign finding in the percutaneous biopsy, and as a malignant finding in the definitive diagnosis. Findings were expressed as absolute numbers, and/or percentages in the qualitative variables, and as mean, standard deviation (SD), and range in the quantitative variables.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Finally we included all patients without atypia, with atypia, and with cancer in order to correlate the findings from the percutaneous biopsy (presence of cancer, or not) with the definitive findings using 2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2 contingency tables, and then proceeded to estimate the diagnostic indices with their corresponding 95 per cent confidence intervals (CI) (sensitivity, specificity, positive predictive value, negative predictive value, and accuracy), and their graphic representation with ROC curves. We used these same variables to conduct the concordance analysis using Cohen's kappa coefficient. <span class="elsevierStyleItalic">p</span>-Value<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 was considered a significant value.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall">We identified a total of 96 patients with histological diagnoses of RS after performing the percutaneous biopsy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The study central group was established with 54 patients without atypia (56.3 per cent).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The age range of patients from this group was between 24 and 71 years old (an average 49.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>10.2 years old).</p><p id="par0095" class="elsevierStylePara elsevierViewall">The most common mammographic finding was the distortion of breast architecture in a total of 32 cases (59.3 per cent), followed by the nodule in 17 patients (31.5 per cent), microcalcifications in 3 patients (5.6 per cent), and focal asymmetry in 2 of these patients (3.7 per cent). The average size was 17.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11.8<span class="elsevierStyleHsp" style=""></span>mm (5–60<span class="elsevierStyleHsp" style=""></span>mm).</p><p id="par0100" class="elsevierStylePara elsevierViewall">Forty-one patients underwent one percutaneous biopsy only. In the remaining 13 cases, two percutaneous biopsies were needed. Data are shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Twelve patients underwent surgical biopsies, and 42 were referred to follow-up. The average follow-up time was 71.4 months (24–113 months). <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the variables included in the study comparing the follow-up patients with the surgical biopsy group. We only found statistically significant differences in the size of the lesion (19.5<span class="elsevierStyleHsp" style=""></span>mm versus 11.8<span class="elsevierStyleHsp" style=""></span>mm; <span class="elsevierStyleItalic">p</span>-value<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.04). <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the number of cancer cases detected by the percutaneous biopsy in the follow-up group compared to the surgical biopsy group. There were not any statistically significant differences (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.778). The overall rate of percutaneous biopsy underestimation in patients without atypia was one case out of a total of 54 patients (1.9 per cent).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">When correlating the study variables with the presence of cancer in the definitive diagnosis we found no differences at all (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05). However, the differences in size between both groups were close to being statistically significant, with an average of 40<span class="elsevierStyleHsp" style=""></span>mm in the cancer group, and an average of 17<span class="elsevierStyleHsp" style=""></span>mm in the cancer-free group (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.057).</p><p id="par0115" class="elsevierStylePara elsevierViewall">The only patient with cancer during follow-up underwent one CNB procedure with a diagnosis of RS without atypia. Ordered by the pathologist, the same percutaneous biopsy was performed through one VAB procedure with the same finding. After two years, one nodule adjacent to the lesion was found with a diagnosis of infiltrating duct carcinoma (IDC) through the CNB (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the findings made through percutaneous biopsies and their correlation with the definitive diagnosis achieved in the 96 cases (patients without atypia, with atypia, and cancer), from which the following diagnostic indices with their corresponding 95 per cent CI were obtained: sensitivity, 92.3 per cent (75.9–97.9 per cent); specificity, 100 per cent (94.8–100 per cent); positive predictive value, 100 per cent (95–100 per cent); negative predictive value, 97.2 per cent (90.4–99.2 per cent), and accuracy, 97.9 per cent (92.7–99.4 per cent). <a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a> shows one ROC curve where these data are graphically represented. The area under the curve was 0.96 (I95 per cent CI; 0.9–1) (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">The concordance using the Cohen's kappa coefficient between the percutaneous biopsy and the definitive diagnosis was 0.95 (95 per cent CI; 0.87–1) (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0130" class="elsevierStylePara elsevierViewall">The radiological definition of RS was established by Tabár and Dean, and in a mammogram it requires the presence of, at least, three of the following criteria: radiolucent core, spiculae irradiating from the radiotransparent center, variable appearance in the different projections, and absence of a palpable lesion, or cutaneous changes.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">4,20</span></a> However, histological tubular carcinomas may present as a lesion similar to the one reported by these authors, which is the reason why it is always necessary to perform a biopsy to confirm diagnosis.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">2</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The RS is present in between 8 per cent, and 16 per cent of all women and goes up to 42 per cent in the contralateral breast in patients with a history of IDC, according to studies based on autopsies.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">11</span></a> Other studies estimate its incidence in autopsies at around 28 per cent, and in biopsized patients due to the presence of radiological anomalies, its incidence remains around 7 per cent.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">21</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">The larger number of RS detection during the last few years has been attributed to the introduction of new more sensitive imaging modalities capable of detecting more of these lesions that before used to be misdiagnosed.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">5</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Our study shows a low rate of percutaneous biopsy underestimation, and excellent diagnostic indices derived from percutaneous biopsies. Equally important is the lack of a statistically significant association between age, type/size of lesion, or type/number of percutaneous biopsies performed and the risk of cancer, and the non-statistically significant differences between the cases underestimated in the follow-up group and the surgical biopsy group in patients without atypia.</p><p id="par0150" class="elsevierStylePara elsevierViewall">In the medical literature we reviewed, we could not find consensus on what cases are truly eligible for surgical biopsy when in the presence of one proliferative lesion after percutaneous biopsy. There is a great variability on the prevalence of carcinomas associated with RS after performing one surgical biopsy, that goes from 0 per cent to 40 per cent.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">12,22</span></a> When a diagnosis of RS with atypical ductal hyperplasia, lobular neoplasm, or papilloma is achieved through one percutaneous biopsy, the frequency of malignancy after surgery is around 26 per cent, number that drops to 7 per cent whenever the RS does not associate this type of proliferative lesion.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">12</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">In our study, the underestimation rate of percutaneous biopsies in the group of patients with RS without atypia was very low (1.9 per cent) and these data are consistent with those reported by other authors such as Li et al. (0.9 per cent),<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">12</span></a> Elizabeth Min (1.6 per cent),<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">22</span></a> Conlon et al. (2 per cent),<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">4</span></a> and Rajan et al. (4.5 per cent).<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a> All of them conclude that the development of cancer close to a region where there already existed one RS is really an incidental finding. This hypothesis is backed by the fact that patients followed-up after RS surgery do not have a higher risk of malignancy than women in the general population. Also, when comparing patients diagnosed with breast cancer with women without cancer, the history of surgery for RS is the same in both groups.<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">24,25</span></a> In our case, there were not any statistically significant differences when comparing cases of cancer between followed patients and patients who underwent surgical biopsies (considered as the best option for a long time).</p><p id="par0160" class="elsevierStylePara elsevierViewall">Some authors claim that the age of the patients, and the size of the lesion may have something to do with the chances of having cancer regions associated with one RS. Thus, lesions <6–7<span class="elsevierStyleHsp" style=""></span>mm in women under 40 do not pose a higher risk of cancer, but in patients over 50 and lesions >2<span class="elsevierStyleHsp" style=""></span>cm, the risk of cancer is higher.<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">17,26</span></a> In our case, the differences in size between patients with and without cancer in the definitive diagnosis were not statistically significant, although they were close to being statistically significant.</p><p id="par0165" class="elsevierStylePara elsevierViewall">This study has some limitations. Although it had access to a numerous population given the circumstances of our center during a long period of time, the number of patients included is not too high, which may lead to inconsistent findings. The type of biopsies performed, the number of samples obtained, and the concordance, or not, between the histological and the radiological findings were not standardized and depended on the radiologist responsible for the patient. Also we did not have the breast cancer family history either, or the personal risk for developing breast cancer. In addition, not all the patients were followed for the same amount of time, since the criterion for referral at discharge was not standardized and depended on other additional factors unforeseen by this analysis.</p><p id="par0170" class="elsevierStylePara elsevierViewall">The surgical biopsy is not free from risks (pain, hematomas, suture dehiscence, infections, risks derived from anesthesia, etc.), which adds to the costs of the intervention, and the anxiety it generates in the patient. The development of multidisciplinary teams, the advances of imaging modalities, and the advances of percutaneous biopsies make follow-up, occasionally, a better option than surgical interventions. This is why we believe that patients diagnosed with RS without atypia through a percutaneous biopsy are eligible for radiological follow-up, and it is not necessary to perform any surgical biopsies since the rate of cancer detected is low and the concordance, sensitivity, and specificity of the percutaneous biopsy for the diagnosis of malignant lesions in one RS is very high. Although the underestimation rate of percutaneous biopsies in patients with RS and atypia has been lower than expected, we think it necessary to make analyses that target this type of lesions in order to confirm the findings reported.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Ethical disclosures</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Protection of human and animal subjects</span><p id="par0230" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed abide by the ethics and regulations of the Human Research Committee, the World Health Organization and the Declaration of Helsinki.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Confidentiality of data</span><p id="par0235" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols from their centers on the disclosure of data from patients.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Right to privacy and informed consent</span><p id="par0240" class="elsevierStylePara elsevierViewall">The authors have obtained prior written informed consent from the aforementioned patients. This document belongs to the corresponding author.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Authors contribution</span><p id="par0175" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1.</span><p id="par0180" class="elsevierStylePara elsevierViewall">Manager of the integrity of the study: JMQ.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2.</span><p id="par0185" class="elsevierStylePara elsevierViewall">Study Idea: MCG, JLRP, SRM, JMQ, MMP, and AML.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3.</span><p id="par0190" class="elsevierStylePara elsevierViewall">Study Design: JMQ, SRM, JLRP, and MCG.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4.</span><p id="par0195" class="elsevierStylePara elsevierViewall">Data Mining: MCG, MMP, JLRP, JMQ, SRM, and AML.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5.</span><p id="par0200" class="elsevierStylePara elsevierViewall">Data Analysis and Interpretation: JMQ, SRM, JLRP, and MCG.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6.</span><p id="par0205" class="elsevierStylePara elsevierViewall">Statistical Analysis: JMQ, and SRM.</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">7.</span><p id="par0210" class="elsevierStylePara elsevierViewall">Reference: JMQ, and SRM.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">8.</span><p id="par0215" class="elsevierStylePara elsevierViewall">Writing: JMQ.</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">9.</span><p id="par0220" class="elsevierStylePara elsevierViewall">Critical review of the manuscript with intellectually relevant remarks: JLRP, MCG, SRM, MMP, and AML.</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">10.</span><p id="par0225" class="elsevierStylePara elsevierViewall">Approval of final version: JLRP, SRM, MCG, AML, MMP, and JMQ.</p></li></ul></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interests</span><p id="par0245" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests associated with this article whatsoever.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres942190" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec915115" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres942191" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec915114" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:3 [ "identificador" => "sec0030" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0025" "titulo" => "Authors contribution" ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflicts of interests" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-12-04" "fechaAceptado" => "2017-04-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec915115" "palabras" => array:5 [ 0 => "Radial scar" 1 => "Complex sclerosing lesion" 2 => "Breast cancer" 3 => "Percutaneous biopsy" 4 => "Surgical biopsy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec915114" "palabras" => array:5 [ 0 => "Cicatriz radial" 1 => "Lesión esclerosante compleja" 2 => "Cáncer de mama" 3 => "Biopsia percutánea" 4 => "Biopsia quirúrgica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate the need for surgical biopsy in patients diagnosed with radial scars without atypia by percutaneous biopsy.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In this retrospective observational study, we selected patients with a histological diagnosis of radial scar in specimens obtained by percutaneous biopsy during an 8-year period. The statistical analysis was centered on patients with radial scar without atypia (we assessed the radiologic presentation, the results of the percutaneous biopsy, and their correlation with the results of surgical biopsy and follow-up) and we added the patients with atypia and cancer in the elaboration of the diagnostic indices.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We identified 96 patients with radial scar on percutaneous biopsy; 54 had no atypia, 18 had atypia, and 24 had cancer. Among patients with radial scar without atypia, there were no statistically significant differences between patients who underwent imaging follow-up and those who underwent surgical biopsy (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05). The rate of underdiagnosis for percutaneous biopsy in patients without atypia was 1.9 per cent. The rates of diagnosis obtained with percutaneous biopsy in relation to follow-up and surgical biopsy in the 96 cases were sensitivity 92.3 per cent, specificity 100 per cent, positive predictive value 100 per cent, negative predictive value 97.2 per cent, and accuracy 97.9 per cent. The area under the ROC curve was 0.96 (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001), and the kappa concordance index was 0.95 (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We consider that it is not necessary to perform surgical biopsies in patients with radial scars without atypia on percutaneous biopsies because the rate of underestimation is very low and the concordance between the diagnosis reached by percutaneous biopsy and the definitive diagnosis is very high.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Evaluar la necesidad de biopsia quirúrgica en pacientes diagnosticadas por biopsia percutánea de cicatriz radial sin atipia.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio observacional retrospectivo y seleccionamos las pacientes con diagnóstico histológico en biopsia percutánea de cicatriz radial durante un periodo de 8 años. El análisis estadístico principal se centró en pacientes con cicatriz radial sin atipia (valoramos la presentación radiológica, los resultados de la biopsia percutánea y su correlación con la biopsia quirúrgica y seguimiento) y añadimos a las pacientes con atipia y cáncer en la elaboración de índices diagnósticos.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Identificamos 96 pacientes con cicatriz radial en biopsia percutánea. Cincuenta y cuatro no presentaban atipia, 18 asociaban algún tipo de atipia y 24, cáncer. No hubo diferencias estadísticas significativas al comparar las pacientes en seguimiento radiológico con aquellas que se sometieron a biopsia quirúrgica en el grupo sin atipia (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0,05). La tasa de infraestimación de la biopsia percutánea en pacientes sin atipia fue del 1,9%. Los índices diagnósticos obtenidos para la biopsia percutánea en relación con el seguimiento y la biopsia quirúrgica en los 96 casos fueron: sensibilidad, 92,3%; especificidad, 100%; valor predictivo positivo, 100%; valor predictivo negativo, 97,2%; y exactitud, 97,9%. El área bajo la curva ROC fue de 0,96 (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001) y el índice de concordancia kappa de 0,95 (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Consideramos que no es necesario realizar biopsia quirúrgica en pacientes diagnosticadas de cicatriz radial sin atipia en biopsia percutánea, ya que la tasa de infraestimación es muy baja y existe un elevado grado de concordancia entre la biopsia percutánea y el diagnóstico definitivo.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Mesa-Quesada J, Romero-Martín S, Cara-García M, Martínez-López A, Medina-Pérez M, Raya-Povedano JL. Cicatriz radial sin atipia en biopsia percutánea. ¿Puede evitarse la biopsia quirúrgica? Radiología. 2017;59:523–530.</p>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1215 "Ancho" => 3333 "Tamanyo" => 229287 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Patients diagnosed of radial scar in the percutaneous biopsy and attitude taken with one of them.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2579 "Ancho" => 2214 "Tamanyo" => 208054 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Types of percutaneous biopsied performed, and management of patients with radial scar without atypia. CNB: core needle biopsy; VAB: vacuum-assisted biopsy.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 3377 "Ancho" => 4000 "Tamanyo" => 2043211 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Fifty-two year-old-patient with a distortion in the external upper quadrant of her left breast (A). The HE<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>40 histological examination after vacuum-assisted biopsy (B) shows breast tissue with hyalinization and areas of central elastosis that capture and distort the ducts. The immunohistochemistry [p63<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>100 (C)], confirms the presence of myoepithelial cells surrounding the ducts–indicative of their non-invasive nature, and all of it compatible with one radial scar. The mammogram (D) and ultrasound (E) of the same patient performed two years after the first diagnosis show one nodule with poorly-defined edges, that is solid in the ultrasound, in the external upper quadrant of her left breast. In the analysis performed using one core needle biopsy [HE<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>40 (F)] the diagnosis of poorly differentiated infiltrating ductal carcinoma in the area of prior radial scar is confirmed.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1636 "Ancho" => 1616 "Tamanyo" => 63617 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">ROC curve. Correlation between the findings of the percutaneous biopsy and the definitive diagnosis. Area under the curve: 0.96; 95 per cent CI: 0.9–1 (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).</p>" ] ] 4 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Quantitative variables expressed in mean and standard deviation (SD); qualitative variables expressed in absolute numbers.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Follow-up (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>42) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Surgical biopsy (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>12) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Statistical significance (<span class="elsevierStyleItalic">p</span>) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Age (years)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>10.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51.25<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>8.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.422 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Size of lesion (mm)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>12.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11.83<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>7.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.04 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Type of lesion</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.123 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nodule \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Distortion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Focal asymmetry \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Microcalcifications \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">1st biopsy</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.278 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CNB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>VAB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">2nd biopsy</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.231 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CNB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>VAB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1594690.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients with radial scar without atypia in the groups of follow-up and surgical biopsy. CNB: core needle biopsy; VAB: vacuum-assisted biopsy.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Definitive diagnosis</th><th class="td" title="table-head " align="left" valign="top" scope="col">Total \t\t\t\t\t\t\n \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cancer \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No cancer \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Follow-up \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 (2.4 per cent) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">41 (97.6 per cent) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">42 (100 per cent) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Surgical biopsy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 (0 per cent) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 (100 per cent) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 (100 per cent) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1594692.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Comparison between follow-up and surgical biopsy groups with respect to the definitive diagnosis in patients without atypia in the percutaneous biopsy.</p>" ] ] 6 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">FN: false negative; FP: false positive; TN: true negative; TP: true positive.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Surgical biopsy and follow-up</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cancer \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No cancer \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Percutaneous biopsy</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 (TP) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (FP) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (FN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70 (TN) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1594691.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Correlation between the percutaneous biopsy findings and the definitive diagnosis in patients without atypia, with atypia, and cancer.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib0135" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The radial scar of the breast diagnosed at core needle biopsy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. 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