Share
array:23 [ "pii" => "S2173510714000482" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2012.11.003" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "649" "copyright" => "SERAM" "copyrightAnyo" => "2012" "documento" => "article" "subdocumento" => "fla" "cita" => "Radiologia. 2014;56:429-34" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1773 "formatos" => array:2 [ "HTML" => 1487 "PDF" => 286 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0033833812002858" "issn" => "00338338" "doi" => "10.1016/j.rx.2012.11.007" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "649" "copyright" => "SERAM" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Radiologia. 2014;56:429-34" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1808 "formatos" => array:3 [ "EPUB" => 13 "HTML" => 1263 "PDF" => 532 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Estimación semiautomática de la densidad mamaria con DM-Scan" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "429" "paginaFinal" => "434" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Semiautomatic estimation of breast density with DM-Scan software" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1245 "Ancho" => 3000 "Tamanyo" => 228519 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Clasificación visual Boyd/BI-RADS<span class="elsevierStyleSup">®</span>.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Martínez Gómez, M. Casals el Busto, J. Antón Guirao, F. Ruiz Perales, R. Llobet Azpitarte" "autores" => array:5 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Martínez Gómez" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Casals el Busto" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Antón Guirao" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Ruiz Perales" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Llobet Azpitarte" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173510714000482" "doi" => "10.1016/j.rxeng.2012.11.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510714000482?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833812002858?idApp=UINPBA00004N" "url" => "/00338338/0000005600000005/v1_201410110204/S0033833812002858/v1_201410110204/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2173510714000470" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2012.06.005" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "624" "copyright" => "SERAM" "documento" => "article" "subdocumento" => "fla" "cita" => "Radiologia. 2014;56:435-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1287 "formatos" => array:2 [ "HTML" => 965 "PDF" => 322 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Report</span>" "titulo" => "Multislice computed tomography for the study of complications of gastric fundoplication" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "435" "paginaFinal" => "439" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tomografía computarizada multicorte para el estudio de complicaciones de la funduplicatura gástrica" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2276 "Ancho" => 846 "Tamanyo" => 183154 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Multidetector computed tomography (MDCT) in a patient with Nissen-fundoplication dehiscence and hernia in the posterior side. (A) Axial image. (B) Oblique coronal reconstruction. (C) Volumetric reconstruction. The study shows the hernia of the posterior side of fundoplication (h). The anterior side of fundoplication (*)–though collapsed can be seen in the right position below the diaphragm. e: esophagus; S: stomach; L: liver.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Rodríguez Carnero, A. Herrasti Gallego, C. García Villafañe, R. Méndez Fernández, R. Rodríguez González" "autores" => array:5 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Rodríguez Carnero" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Herrasti Gallego" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "García Villafañe" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Méndez Fernández" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Rodríguez González" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0033833812002111" "doi" => "10.1016/j.rx.2012.06.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833812002111?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510714000470?idApp=UINPBA00004N" "url" => "/21735107/0000005600000005/v1_201411230009/S2173510714000470/v1_201411230009/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173510714000494" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2012.12.001" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "657" "copyright" => "SERAM" "documento" => "article" "subdocumento" => "fla" "cita" => "Radiologia. 2014;56:420-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2075 "formatos" => array:2 [ "HTML" => 1711 "PDF" => 364 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Value of doppler ultrasonography in the study of hemodialysis peripheral vascular access dysfunction" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "420" "paginaFinal" => "428" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Valor de la ecografía doppler en la disfunción de los accesos vasculares periféricos para hemodiálisis" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 323 "Ancho" => 1900 "Tamanyo" => 105835 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Vascular access with functioning polytetrafluoroethylene (PTFE) prostheses and no ultrasound alterations. Both anastomoses–proximal to the efferent vein (V, efferent vein) and distal to the brachial artery (dotted line). The PTFE prosthesis whose wall can be seen with a triple band with a hypoechoic central line shows some irregularities secondary to repeated punctures.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "T. Moreno Sánchez, C. Martín Hervás, E. Sola Martínez, F. Moreno Rodríguez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "T." "apellidos" => "Moreno Sánchez" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Martín Hervás" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Sola Martínez" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Moreno Rodríguez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0033833813000088" "doi" => "10.1016/j.rx.2012.12.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833813000088?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510714000494?idApp=UINPBA00004N" "url" => "/21735107/0000005600000005/v1_201411230009/S2173510714000494/v1_201411230009/en/main.assets" ] "en" => array:21 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Semiautomatic estimation of breast density with DM-Scan software" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "429" "paginaFinal" => "434" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Martínez Gómez, M. Casals el Busto, J. Antón Guirao, F. Ruiz Perales, R. Llobet Azpitarte" "autores" => array:5 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Martínez Gómez" "email" => array:1 [ 0 => "martinez_inm@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Casals el Busto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Antón Guirao" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Ruiz Perales" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "R." "apellidos" => "Llobet Azpitarte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Programa de Cribado de Cáncer de Mama de la Comunidad Valenciana, Unidad de Alzira, Alzira, Valencia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Programa de Cribado de Cáncer de Mama de la Comunidad Valenciana, Unidad de Valencia, Valencia, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Instituto Tecnológico de Informática, Universidad Politécnica de Valencia, Valencia, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Programa de Cribado de Cáncer de Mama, Centro Superior de Investigación Salud Pública (CSISP), Valencia, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estimación semiautomática de la densidad mamaria con DM-Scan" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1761 "Ancho" => 1575 "Tamanyo" => 273610 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">DM-Scan user interface.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Screening mammography programs have reduced the rates of mortality of breast cancer up to 22% in women >50 years old and 15% in women between 40 and 49 years old.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> However, the larger the breast density is, the lower the sensibility of the mammography – also associated with higher rates of interval cancers with poor prognosis when detected clinically.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a> A dense breast tissue is <span class="elsevierStyleItalic">per se</span> a risk factor for breast cancer that is 4–6 times bigger in high dense breasts (breast density >75%) than in fat breasts (breast density <10%).<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4–6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Breast density shows the amount of fibrograndular tissue with respect to breast fat. Since 1976 when Wolfe<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> associated breast density with breast cancer and defined a 4 grade-categorization to grade it different categorizations have been used–all of them based on qualitative<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> or quantitative<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9–11</span></a> criteria from visual or semiautomatic analysis of mammographies. BI-RADS<span class="elsevierStyleSup">®10</span> 4th edition published by the American College of Radiology (ACR) standardizes breast density in the visual inspection by using a discrete quantitative scale categorizing density into four different categories. Both this and Boyd's categorization establishing 6 different quantitative categories<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> are the most widely accepted scales today. There is proof that the quantitative measure in the mammographic percentage of dense area is a better predictor of risk than the categorization in qualitative categories.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Today there are several automation modalities<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> that improve the estimation of breast density and the categorization of parenchymal patterns like, for instance, the modalities introduced by Cumulus from the University of Toronto<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> or Madena from the University of Southern California.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> These modalities use analog mammographies that need to be scanned and digitized. Nevertheless, digital mammography is a widely used and accepted modality. The goal of this study is to develop a computer program that will allow us to analyze and estimate an objective and reproducible breast density in direct digital mammographies without further processing.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14–18</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0020" class="elsevierStylePara elsevierViewall">Six hundred and fifty-five (655) direct digital mammographies in a former project <span class="elsevierStyleItalic">Determinants of Density in Mammography in Spain</span> (DDM-Spain) (project FIS PI060386) that investigated breast density as one of the risk factors of breast cancer in 3584 women from 7 Spanish screening centers. For our study the mammographies were randomized out of 3 screening centers equipped with digital mammograms: Barcelona – Hologic<span class="elsevierStyleSup">®</span> Lorad M-IV™ digital mammogram (Bedford, MA, USA); Palma de Mallorca– Siemens Novation<span class="elsevierStyleSup">®</span> digital mammogram (Muenchen, Germany); and Valencia–Senographe 2000D<span class="elsevierStyleSup">®</span> GE Medical System S.A. (Buc Cedex, France). Women were between 45 and 69 years of age. Women diagnosed with ovarian or breast cancers, those who underwent a breast surgical procedure or those who were prosthetic carriers were precluded. Both approval and informed consent came from Carlos III Institute of Health Bioethical Committee (Madrid, Spain).</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study modality</span><p id="par0025" class="elsevierStylePara elsevierViewall">In a 1st stage 3 highly experienced radiologists in screening mammographies visually categorized the breast density of 655 mammographies according to Boyd and BI-RADS<span class="elsevierStyleSup">®</span> scales (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Previously they had done a combined training with 300 direct digital images from different screening programs–technically compatible though. To assess breast density the left craniocaudal view (CCV) was used because it has fewer technical issues when proceeding to segment the image since it includes less chest muscle than other projections. Since to categorize breast density a high resolution image is not necessary for the analysis one conventional 17″ monitor and a non-diagnostic radiologic image visualization software were used (K-PACS V1.6,0; free software, <a id="intr0010" class="elsevierStyleInterRef" href="http://www.k-pacs.de/">http://www.k-pacs.de</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In a 2nd stage 3 months later we used a computer application (MD-Scan) specifically designed for this study in the Universidad Politécnica de Valencia (Valencia, Spain). It is a tool used for computed assisted design (CAD) in order to assess breast density and simultaneously reduce its subjectivity. This application was designed to work with PNG format-images that use a compression algorithm to reduce the weight of the image without losing quality. This is why the original DIGICOM digital format original images were converted into PNG format images through the DIGICOM 2 free software.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> When loading the mammographic image DM-Scan first processes it for the sake of identifying the breast and then proceeds to segment it automatically– defining the breast contour while isolating the rest of the image. When segmentation is not precise like when chest muscle or other image components are included in the segmented area, it is possible to preclude them. Through this process we can obtain the total size of the breast measured in number of pixels. Then the radiologist defines the threshold of brightness to establish the separation between the dense and the fat tissue which in turn allows us to know the dense tissue total area also measured in number of pixels and thus its exact percentage with respect to the breast total size.</p><p id="par0035" class="elsevierStylePara elsevierViewall">We need to remember that the attenuation of X-rays and therefore the level of brightness in the mammography is not only based on the tissue density but also on its thickness. This means that the breast side closer to the chest muscle is sometimes brighter than peripheral side and this is why the selection of dense tissue only from a threshold of brightness usually picks out regions closer to the chest muscle. To correct this defect a digital filter called “breast filter” is used to estimate breast thickness in each image point while proportionally darkening the corresponding pixel. Given that the real thickness of each breast is not known the application gives us manual controls that allow us to edit the parameters configuring this filter. Particularly the brightness of each breast pixel <span class="elsevierStyleItalic">p</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">ij</span></span> multiplies by a correction coefficient <span class="elsevierStyleItalic">k</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">ij</span></span> based on an alpha parameter that takes values between 0 and 1–defined by the user so that:<elsevierMultimedia ident="eq0005"></elsevierMultimedia>where <span class="elsevierStyleItalic">d</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">ij</span></span> represents the distance relative to pixel <span class="elsevierStyleItalic">p</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">ij</span></span> at the rim of the breast. In <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a> the graphic interface of the application is shown.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">To estimate the inter-observer concordance in both stages 10% of the images were randomized and analyzed twice with a 2-month separation between both readings. In both stages the inter-observer concordance was estimated among pairs of radiologists and then we compared the concordance averages of the visual and semiautomatic methods. For the results expressed as categories–visual categorization, the concordance was analyzed through the Kappa (<span class="elsevierStyleItalic">k</span>) coefficient with quadratic weights and 95% intervals of confidence (IC). For the results expressed in the continuous-scale score (DM-Scan) the interclass correlation coefficient (ICC) was used. To assess the Kappa coefficient a weighted equation with quadratic weights was used so that disagreements in the most distant categories have a greater penalty. Given two (2) categories <span class="elsevierStyleItalic">i</span>, <span class="elsevierStyleItalic">j</span>, the weighting factor <span class="elsevierStyleItalic">W</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">i,j</span></span> used was:<elsevierMultimedia ident="eq0015"></elsevierMultimedia>where <span class="elsevierStyleItalic">N</span> represents the number of categories. The Kappa coefficient with quadratic weights is statistically comparable to the ICC<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> that in turn allows us to make comparisons between the two (2) methods studies.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The statistical study was done with a free <span class="elsevierStyleItalic">software</span> R (R Development Core Team, 2011). R is a free <span class="elsevierStyleItalic">software</span> environment for the analysis of statistical results. To estimate concordance the irr<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> package was used.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Categorization through visual inspection</span><p id="par0060" class="elsevierStylePara elsevierViewall">In the inter-observer concordance study the average concordance was 0.876 (95% CI: 0.873–0.879) in the Boyd scale and 0.823 (95% CI: 0.818–0.829) in the BI-RADS<span class="elsevierStyleSup">®</span> scale. The average intra-observer concordance was 0.813 (95% CI: 0.796–0.829) in the Boyd scale and 0.770 (95% CI: 0.742–0.797) in the BI-RADS<span class="elsevierStyleSup">®</span> scale. When comparing both scales the average concordance seen is slightly higher with the Boyd scale and it is remarkable that the intra-observer concordance is lower than the inter-observer concordance in both scales.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Semiautomatic categorization</span><p id="par0065" class="elsevierStylePara elsevierViewall">In the analysis done through DM-Scan the average inter- and intra-observer concordance was ICC<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.92 (95% CI: 0.916–0.928)–remarkably better than the concordance with respect to the visual categorization. In this case the intra-observer concordance was the same as the inter-observer concordance.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">This study showed that a computer application automating the determination of breast density obtains excellent intra- and inter-observer concordances while improving visual inspection.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Today breast density can be estimated visually but there is variability among radiologists or in one radiologist only. The concordances reported in former studies go from moderate to really good concordances like <span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.54 in Ciatto et al.’s study,<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.77 in Ooms et al.’s study,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a><span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.85 in Perez-Gómez et al.’s study<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> and <span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.90 in Garrido-Estepa's study<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> where only one radiologist categorized the same group of mammographies into 4 grades. The variability is not easy to explain but it can be due to the various methods used since the studies are different in the number of mammographies analyzed, the number of radiologists involved (between 1 and 12), the radiologist's own experience, the pre-study training, the type of mammography (analogical or digital) and the probability of not coinciding–variability that is when assigning a quantitative category to the images found in the barrier that separates 2 categories. Also various studies do not accurately specify the statistical method used to estimate the Kappa coefficient that makes it hard to compare the results found. We can say that the visual estimate of breast density–subject to a high level of subjectivity is not easy to do. Yet despite the intrinsic difficulty of this task our visual concordances were included between the <span class="elsevierStyleItalic">k</span> coefficients of 0.61 and 0.80 so they are good.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Unlike other studies<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,23</span></a> it is surprising that our average intra-observer concordance in the visual analysis is lower than the inter-observer concordance. It is remarkable that both studies have not been done on the same sample– in the intra-observer study only 10% of the images were used. Also, the inter-observer study was done immediately after the previous training while the intra-observer study was done months later–something that could justify a minor adjustment to the criteria of categorization agreed during the previous training. However, the difference vanished when the DM-Scan screening was done that other than obtaining excellent concordance rates it showed no discordances in the inter- and intra-observer variability regardless of the passing of time. So the estimation of breast density can be more accurate and objective with computer applications capable of determining breast density automatic or semi-automatically.</p><p id="par0085" class="elsevierStylePara elsevierViewall">One of the first authors to suggest the use of computers as tools to determine breast density was Boyd<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> who introduced a semi-automatic method (Cumulus)<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> to estimate breast density based on the manual selection of 2 thresholds for the segmentation of breast and dense tissue respectively. Unlike other applications<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,25</span></a> the application of DM-Scan makes an initial estimate of the percentage of breast tissue that can be accepted or modified which speeds up and facilitates its treatment while reducing the subjectivity of manual manipulation of the measure. It also corrects bright differences due to breast thickness and not density.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Among the limitations of this study we have to bring up that we did not estimate the extra time necessary to add the estimation of breast density to daily routine that other former studies have estimated between 18 and 40 per projection<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,26</span></a> and 5–8<span class="elsevierStyleHsp" style=""></span>min per study.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> As it happens with other semi-automatic tools for the estimation of breast density and even if they can improve the results of visual inspection there is a certain degree of subjectivity since they need one operator to set the threshold to separate dense from fat tissue–something that can induce certain variability in the estimation. But this is not a real limitation given our goal was to estimate it for the semi-automatic measure too.</p><p id="par0095" class="elsevierStylePara elsevierViewall">With a significantly higher number of mammographies than the rest of studies published our results confirm those obtained in other studies done through visual<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,22</span></a> or semi-automatic<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> categorization or when comparing both visual and semi-automatic categorizations.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,15,25,26</span></a> Yet despite both modalities, visual inspection and DM-Scan are valid to estimate breast density, the DM-Scan modality is more precise, reduces subjectivity significantly, is more reliable to establish breast density and consequently allows us to homogenize criteria and helps us to design more adequate screening protocols based on breast density.</p><p id="par0100" class="elsevierStylePara elsevierViewall">In sum our study confirms that the estimation of breast density with the semi-automatic DM-Scan application is reliable and easily reproducible while reducing the subjectivity and variability of visual inspection.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Ethical responsibilities</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Protection of people and animals</span><p id="par0105" class="elsevierStylePara elsevierViewall">Authors confirm that for this investigation no experiments with human beings or animals have been carried out.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Data confidentiality</span><p id="par0110" class="elsevierStylePara elsevierViewall">Authors confirm that there are no personal data from patients in this article.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Right to privacy and informed consent</span><p id="par0115" class="elsevierStylePara elsevierViewall">Authors confirm that they have obtained the written informed prior consent from patients and/or subjects appearing in this article. This document is in the possession of the corresponding author.</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Authors</span><p id="par0120" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0125" class="elsevierStylePara elsevierViewall">Manager of the integrity of the study: IMG.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2</span><p id="par0130" class="elsevierStylePara elsevierViewall">Original Idea of the Study: IMG and MCE.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3</span><p id="par0135" class="elsevierStylePara elsevierViewall">Study Design: IMG and MCE.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4</span><p id="par0140" class="elsevierStylePara elsevierViewall">Data Mining: IMG, MCE, FRP, R Ll and JA.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5</span><p id="par0145" class="elsevierStylePara elsevierViewall">Data Analysis and Interpretation: IMG, MCE, FRP, R Ll and JA.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6</span><p id="par0150" class="elsevierStylePara elsevierViewall">Statistical Analysis: R Ll and JA.</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">7</span><p id="par0155" class="elsevierStylePara elsevierViewall">Reference Search: MCE and IMG.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">8</span><p id="par0160" class="elsevierStylePara elsevierViewall">Writing: IMG, MCE, R Ll, FRP and JA.</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">9</span><p id="par0165" class="elsevierStylePara elsevierViewall">Manuscript critical review: MCE, FRP and R Ll.</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">10</span><p id="par0170" class="elsevierStylePara elsevierViewall">Final Version Approval: IMG, MCE, FRP and R Ll.</p></li></ul></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflict of interests</span><p id="par0175" class="elsevierStylePara elsevierViewall">Authors reported no conflicts of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:2 [ "identificador" => "xres384943" "titulo" => array:5 [ 0 => "Abstract" 1 => "Objective" 2 => "Materials and methods" 3 => "Results" 4 => "Conclusion" ] ] 1 => array:2 [ "identificador" => "xpalclavsec363759" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres384942" "titulo" => array:5 [ 0 => "Resumen" 1 => "Objetivo" 2 => "Material y métodos" 3 => "Resultados" 4 => "Conclusión" ] ] 3 => array:2 [ "identificador" => "xpalclavsec363760" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Study modality" ] ] ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Statistical analysis" ] 7 => array:3 [ "identificador" => "sec0030" "titulo" => "Results" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Categorization through visual inspection" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Semiautomatic categorization" ] ] ] 8 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 9 => array:3 [ "identificador" => "sec0050" "titulo" => "Ethical responsibilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Protection of people and animals" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Data confidentiality" ] 2 => array:2 [ "identificador" => "sec0065" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0070" "titulo" => "Authors" ] 11 => array:2 [ "identificador" => "sec0075" "titulo" => "Conflict of interests" ] 12 => array:2 [ "identificador" => "xack104582" "titulo" => "Acknowledgements" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-07-27" "fechaAceptado" => "2012-11-22" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec363759" "palabras" => array:7 [ 0 => "Mammography" 1 => "Breast cancer" 2 => "Breast density" 3 => "Digital processing of mammograms" 4 => "Computer-assisted diagnosis" 5 => "Intraobserver variability" 6 => "Interobserver variability" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec363760" "palabras" => array:7 [ 0 => "Mamografía" 1 => "Cáncer de mama" 2 => "Densidad mamaria" 3 => "Procesamiento digital de mamografías" 4 => "Diagnóstico asistido por ordenador" 5 => "Variabilidad intraobservador" 6 => "Variabilidad interobservador" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To evaluate the reproducibility of the calculation of breast density with DM-Scan software, which is based on the semiautomatic segmentation of fibroglandular tissue, and to compare it with the reproducibility of estimation by visual inspection.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The study included 655 direct digital mammograms acquired using craniocaudal projections. Three experienced radiologists analyzed the density of the mammograms using DM-Scan, and the inter- and intra-observer agreements between pairs of radiologists for the Boyd and BI-RADS<span class="elsevierStyleSup">®</span> scales were calculated using the intraclass correlation coefficient. The Kappa index was used to compare the inter- and intra-observer agreements with those obtained previously for visual inspection in the same set of images.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">For visual inspection, the mean inter-observer agreement was 0.876 (95% CI: 0.873–0.879) on the Boyd scale and 0.823 (95% CI: 0.818–0.829) on the BI-RADS<span class="elsevierStyleSup">®</span> scale. The mean intra-observer agreement was 0.813 (95% CI: 0.796–0.829) on the Boyd scale and 0.770 (95% CI: 0.742–0.797) on the BI-RADS<span class="elsevierStyleSup">®</span> scale. For DM-Scan, the mean inter- and intra-observer agreement was 0.92, considerably higher than the agreement for visual inspection.</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The semiautomatic calculation of breast density using DM-Scan software is more reliable and reproducible than visual estimation and reduces the subjectivity and variability in determining breast density.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar la reproducibilidad del cálculo de la densidad mamaria con la aplicación informática DM-Scan, basada en la segmentación semiautomática del tejido fibroglandular, y compararla con la de la inspección visual.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El estudio incluyó 655 mamografías digitales directas en proyección cráneo-caudal. Tres expertos radiólogos analizaron la densidad de las mamografías con DM-Scan, y se calcularon las concordancias inter e intraobservador entre pares de radiólogos para las escalas Boyd y BI-RADS<span class="elsevierStyleSup">®</span>, utilizando el índice de correlación intraclase. Las concordancias se compararon con las obtenidas previamente para la inspección visual, en el mismo conjunto de imágenes, utilizando el índice Kappa.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Con el análisis visual, la concordancia media interobservador fue de 0,876 (IC 95%: 0,873-0,879) para la escala de Boyd, y 0,823 (IC 95%: 0,818-0,829) para la clasificación BI-RADS<span class="elsevierStyleSup">®</span>. La concordancia intraobservador fue de 0,813 (IC 95%: 0,796-0,829) para la escala de Boyd, y 0,770 (IC 95%: 0,742-0,797) para la clasificación BI-RADS<span class="elsevierStyleSup">®</span>. Con DM-Scan, la concordancia media inter e intraobservador fue de 0,92, notablemente superior a las concordancias de la clasificación visual.</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El cálculo de la densidad mamaria con la aplicación semiautomática DM-Scan es más fiable y reproducible, y disminuye la subjetividad y variabilidad de la estimación visual.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Martínez Gómez I, Casals el Busto M, Antón Guirao J, Ruiz Perales F, Llobet Azpitarte R. Estimación semiautomática de la densidad mamaria con DM-Scan. Radiología. 2014;56:429–434</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 737 "Ancho" => 1795 "Tamanyo" => 137555 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Boyd/BI-RADS<span class="elsevierStyleSup">®</span> visual classification.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1761 "Ancho" => 1575 "Tamanyo" => 273610 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">DM-Scan user interface.</p>" ] ] 2 => array:5 [ "identificador" => "eq0005" "tipo" => "MULTIMEDIAFORMULA" "mostrarFloat" => false "mostrarDisplay" => true "Formula" => array:5 [ "Matematica" => "kij=α+(1−α)dij" "Fichero" => "si1.jpeg" "Tamanyo" => 1057 "Alto" => 15 "Ancho" => 119 ] ] 3 => array:5 [ "identificador" => "eq0015" "tipo" => "MULTIMEDIAFORMULA" "mostrarFloat" => false "mostrarDisplay" => true "Formula" => array:5 [ "Matematica" => "Wi,j=1−(i−j)2(N−1)2" "Fichero" => "si2.jpeg" "Tamanyo" => 1493 "Alto" => 40 "Ancho" => 123 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Bartella" 1 => "C.S. Smith" 2 => "D.D. Dershaw" 3 => "L. Liberman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rcl.2006.10.007" "Revista" => array:6 [ "tituloSerie" => "Radiol Clin North Am" "fecha" => "2007" "volumen" => "45" "paginaInicial" => "45" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17157623" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Tabár" 1 => "B. Vitak" 2 => "T.H. Chen" 3 => "A.M. Yen" 4 => "A. Cohen" 5 => "T. Tot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiol.11110469" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "2011" "volumen" => "260" "paginaInicial" => "658" "paginaFinal" => "663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21712474" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The quantitative analysis of mammographic densities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.W. Byng" 1 => "N.F. Boyd" 2 => "E. Fishell" 3 => "R.A. Jong" 4 => "M.J. Yaffe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Phys Med Biol" "fecha" => "1994" "volumen" => "39" "paginaInicial" => "1629" "paginaFinal" => "1638" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15551535" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mammographic density and the risk and detection of breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.F. Boyd" 1 => "H. Guo" 2 => "L.J. Martin" 3 => "L. Sun" 4 => "J. Stone" 5 => "E. Fishell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa062790" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "227" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17229950" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V.A. McCormack" 1 => "I. dos Santos Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1055-9965.EPI-06-0034" "Revista" => array:6 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "2006" "volumen" => "15" "paginaInicial" => "1159" "paginaFinal" => "1169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16775176" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mammographic density: a useful biomarker for breast cancer risk in epidemiologic studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Ursin" 1 => "S.A. Qureshi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Norsk Epidemiologi" "fecha" => "2009" "volumen" => "19" "paginaInicial" => "59" "paginaFinal" => "68" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast patterns as an index of risk for developing breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.N. Wolfe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Roentgenol" "fecha" => "1976" "volumen" => "126" "paginaInicial" => "1130" "paginaFinal" => "1137" "itemHostRev" => array:3 [ "pii" => "S0190962212003635" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Percentage density, Wolfe's and Tabar's mammographic patterns: agreement and association with risk factors for breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I.T. Gram" 1 => "Y. Bremnes" 2 => "G. Ursin" 3 => "G. Maskarinec" 4 => "N. Bjurstam" 5 => "E. Lund" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Breast Cancer Res" "fecha" => "2005" "volumen" => "7" "paginaInicial" => "854" "paginaFinal" => "861" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DDM-Spain. Evaluation of mammographic density patterns: reproducibility and concordance among scales" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Garrido-Estepa" 1 => "F. Ruiz-Perales" 2 => "J. Miranda" 3 => "J. Ascunce" 4 => "I. González-Román" 5 => "C. Sanchez-Contador" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2407-10-485" "Revista" => array:5 [ "tituloSerie" => "BMC Cancer" "fecha" => "2010" "volumen" => "10" "paginaInicial" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20836850" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast imaging reporting and data system (BI-RADS<span class="elsevierStyleSup">®</span>)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American College of Radiology" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "4th ed." "fecha" => "2003" "editorial" => "American College of Radiology" "editorialLocalizacion" => "Reston, VA" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantitative classification of mammographic densities and breast cancer risk: results from the Canadian National Breast Screening Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.F. Boyd" 1 => "J.W. Byng" 2 => "R.A. Jong" 3 => "E.K. Fishell" 4 => "L.E. Little" 5 => "A.B. Miller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "1995" "volumen" => "87" "paginaInicial" => "670" "paginaFinal" => "675" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7752271" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An automated approach for estimation of breast density" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.J. Heine" 1 => "M.J. Carston" 2 => "C.G. Scott" 3 => "K. Brandt" 4 => "F.-F. Wu" 5 => "V. Pankratz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1055-9965.EPI-08-0170" "Revista" => array:6 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "2008" "volumen" => "17" "paginaInicial" => "3090" "paginaFinal" => "3097" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18990749" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The detection of changes in mammographic densities" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Ursin" 1 => "M.A. Astrahan" 2 => "M. Salane" 3 => "Y.R. Parisky" 4 => "J.G. Pearce" 5 => "J.R. Daniels" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "1998" "volumen" => "7" "paginaInicial" => "43" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9456242" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mammographic density estimation: comparison among BI-RADS categories, a semi-automated software and a fully automated one" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Tagliafico" 1 => "G. Tagliafico" 2 => "S. Tosto" 3 => "F. Chiesa" 4 => "C. Martinoli" 5 => "L.E. Derchi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.breast.2008.09.005" "Revista" => array:6 [ "tituloSerie" => "Breast" "fecha" => "2009" "volumen" => "18" "paginaInicial" => "35" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19010678" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A novel breast tissue density classification methodology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Oliver" 1 => "J. Freixenet" 2 => "R. Marti" 3 => "J. Pont" 4 => "E. Pérez" 5 => "E.R. Denton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1109/TITB.2007.903514" "Revista" => array:6 [ "tituloSerie" => "IEEE Trans Inf Technol Biomed" "fecha" => "2008" "volumen" => "12" "paginaInicial" => "55" "paginaFinal" => "65" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18270037" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mammography: interobserver variability in breast density assessment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.A. Ooms" 1 => "H. Zonderland" 2 => "M. Eijkemans" 3 => "B. Mahdavian Delavary" 4 => "C. Burger" 5 => "A. Ansink" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.breast.2007.04.007" "Revista" => array:6 [ "tituloSerie" => "Breast" "fecha" => "2007" "volumen" => "16" "paginaInicial" => "568" "paginaFinal" => "576" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18035541" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Computerized image analysis: estimation of breast density in mammograms" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Zhou" 1 => "H.P. Chan" 2 => "N. Petrick" 3 => "M.A. Helvie" 4 => "M.M. Goodsitt" 5 => "B. Sahiner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1118/1.1376640" "Revista" => array:6 [ "tituloSerie" => "Med Phys" "fecha" => "2001" "volumen" => "28" "paginaInicial" => "1056" "paginaFinal" => "1069" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11439475" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimación de la densidad mamaria asistida por ordenador" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Llobet" 1 => "F. Ruiz Perales" 2 => "J.A. Solves" 3 => "J.C. Pérez-Cortés" 4 => "D. Salas" 5 => "M. Pollán" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Informática y Salud" "fecha" => "2009" "paginaInicial" => "84" "paginaFinal" => "89" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dicom2, a free medical image and dicom converter" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Barre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2007" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The equivalence of weighted Kappa and the intraclass correlation coefficient as measures of reliability" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.L. Fleiss" 1 => "J. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Educ Psychol Meas" "fecha" => "1973" "volumen" => "33" "paginaInicial" => "613" "paginaFinal" => "619" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Various coefficients of interrater reliability and agreement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Gamer" 1 => "J. Lemon" 2 => "I. Fellows" 3 => "P. Singh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2010" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Categorizing breast mammographic density: intra and interobserver reproducibility of BI-RADS density categories" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Ciatto" 1 => "N. Houssami" 2 => "A. Apruzzese" 3 => "E. Basetti" 4 => "B. Brancato" 5 => "F. Carozzi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.breast.2004.12.004" "Revista" => array:6 [ "tituloSerie" => "Breast" "fecha" => "2005" "volumen" => "14" "paginaInicial" => "269" "paginaFinal" => "275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16085233" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Women's features and inter/intra rater agreement on mammographic density assessment in full-field digital mammograms (DDM-SPAIN)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Pérez-Gómez" 1 => "F. Ruiz" 2 => "I. Martínez" 3 => "M. Casals" 4 => "J. Miranda" 5 => "C. Sánchez-Contador" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10549-011-1833-3" "Revista" => array:6 [ "tituloSerie" => "Breast Cancer Res Treat" "fecha" => "2012" "volumen" => "132" "paginaInicial" => "287" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22042363" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Practical statistics for medical research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.G. Altman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ "edicion" => "first ed." "titulo" => "Monographs on statistics and applied probability" "fecha" => "1991" "editorial" => "Chapman and Hall" "editorialLocalizacion" => "New York" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Density is in the eye of the beholder: visual versus semi-automated assessment of breast density on standard mammograms" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.B. Lobbes" 1 => "J.P. Cleutjens" 2 => "V. Lima Passos" 3 => "C. Frotscher" 4 => "M.J. Lahaye" 5 => "K.B. Keymeulen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s13244-011-0139-7" "Revista" => array:6 [ "tituloSerie" => "Insights Imaging" "fecha" => "2012" "volumen" => "3" "paginaInicial" => "91" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22696002" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mammographic density measured with quantitative computer-aided method: comparison with radiologists’ estimates and BI-RADS<span class="elsevierStyleSup">®</span> categories" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.E. Martin" 1 => "M.A. Helvie" 2 => "C. Zhou" 3 => "M.A. Roubidoux" 4 => "J.E. Bailey" 5 => "C. Paramagul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiol.2402041947" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "2006" "volumen" => "240" "paginaInicial" => "656" "paginaFinal" => "665" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16857974" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack104582" "titulo" => "Acknowledgements" "texto" => "<p id="par0180" class="elsevierStylePara elsevierViewall">We wish to thank the following institutions: Centro Nacional de Salud: Instituto de Salud Carlos III de Madrid, Fundación Gent x Gent (EDEMAC Project), Fondo Español de Investigación Sanitaria and the Federación Española de Pacientes con Cáncer de Mama (FECMA) for financing the project <span class="elsevierStyleItalic">Determinants of Density in Mammography in Spain</span> (DDM-Spain)–origin of the mammographies presented in this study.</p> <p id="par0185" class="elsevierStylePara elsevierViewall">We also wish to thank other members of DDM-Spain: Pilar Moreo, Pilar Moreno y Soledad Abad (Aragón, Spain); Francisca Collado y Magdalena Moyá (Baleares, Spain); Isabel González, Carmen Pedraz and Francisco Casanova (Castilla-León, Spain); Mercé Peris (Cataluña, Spain); Carmen Santamaría, José Antonio Vázquez Carrete, Montserrat Corujo and Ana Belén Fernández (Galicia, Spain); Nieves Ascunce, María Ederra, Milagros García and Ana Barcos (Navarra, Spain); Manuela Alcaraz, Jesús Vioque (C. Valenciana, Spain); Virginia Lope, Nuria Aragonés and Anna Cabanes (Madrid, Spain).</p> <p id="par0190" class="elsevierStylePara elsevierViewall">Also thanks to the Instituto Tecnológico de Informática de la Universidad Politécnica de Valencia for designing and producing the DM-Scan for automatic and semi-automatic readings and to doctors Beatriz Pérez-Gómez and Marina Pollán from the Enviromental Epidemiology and Cancer Unit of the Centro Nacional de Epidemiología, Instituto de Salud Carlos III, and doctors Dolores Salas and Josefa Miranda from the Dirección General Salud Pública, Programa de Cribado de Cáncer de Mama, Centro Superior de Investigación Salud Pública (CSISP) (Valencia, Spain), and doctor Carmen Palop (Unidad de Prevención de Cáncer de Mama de Sagunto, Valencia, Spain) for their collaboration and help during this study.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21735107/0000005600000005/v1_201411230009/S2173510714000482/v1_201411230009/en/main.assets" "Apartado" => array:4 [ "identificador" => "8098" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735107/0000005600000005/v1_201411230009/S2173510714000482/v1_201411230009/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510714000482?idApp=UINPBA00004N" ]
