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array:24 [ "pii" => "S2173510717300794" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2017.06.005" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "989" "copyright" => "SERAM" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2018;60:39-48" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1 "HTML" => 1 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S003383381730111X" "issn" => "00338338" "doi" => "10.1016/j.rx.2017.06.009" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "989" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2018;60:39-48" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1296 "formatos" => array:3 [ "EPUB" => 1 "HTML" => 972 "PDF" => 323 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Radiología en Imágenes</span>" "titulo" => "Papel de los estudios de imagen en el diagnóstico etiológico de las bronquiectasias: la distribución es la clave" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "39" "paginaFinal" => "48" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The role of imaging in the diagnosis of bronchiectasis: the key is in the distribution" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figura 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 883 "Ancho" => 1300 "Tamanyo" => 127150 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Mujer de 58 años de edad con tos crónica de varios años de evolución. La imagen axial de TC muestra un engrosamiento bronquial difuso y bronquiectasias cilíndricas segmentarias y subsegmentarias en el lóbulo medio y la língula (flechas). Esta distribución es característica de la infección crónica por micobacterias no tuberculosas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Bueno, L. Flors" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Bueno" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Flors" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173510717300794" "doi" => "10.1016/j.rxeng.2017.06.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510717300794?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S003383381730111X?idApp=UINPBA00004N" "url" => "/00338338/0000006000000001/v1_201802072317/S003383381730111X/v1_201802072317/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173510717300757" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2017.10.004" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "1018" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2018;60:49-56" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Report</span>" "titulo" => "Dynamic magnetic resonance imaging of the breast: Comparison of gadobutrol vs. Gd-DTPA" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "49" "paginaFinal" => "56" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Resonancia magnética dinámica de mama: estudio comparativo de gadobutrol y Gd-DTPA" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2307 "Ancho" => 3000 "Tamanyo" => 492842 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Patient diagnosed of right breast neoplasm through ultrasound-guided biopsy. Bilateral breast MRI with contrast. (a) T1-weighted sequence without contrast. One ROI is placed within the mass showing the area in square centimeters, the mean, and the standard deviation of the signal intensity in the area measured by the ROI. (b) T1-weighted sequence with contrast during the first time of acquisition (<span class="elsevierStyleItalic">T</span><span class="elsevierStyleInf">1</span>) after the administration of contrast. ROI placement in the area of the lesion that has the highest enhancement of all. (c) T1-weighted sequence with contrast during the second time of acquisition (<span class="elsevierStyleItalic">T</span><span class="elsevierStyleInf">2</span>). (d) T1-weighted sequence with contrast during the third time of acquisition <span class="elsevierStyleItalic">T</span><span class="elsevierStyleInf">3</span>. (e) T1-weighted sequence with contrast during the fourth time of acquisition <span class="elsevierStyleItalic">T</span><span class="elsevierStyleInf">4</span>. (f) T1-weighted sequence during the fifth and last time of acquisition T<span class="elsevierStyleInf">5</span>. The ROI is maintained in the same location during the entire study. In this case, there is intense and fast uptake in <span class="elsevierStyleItalic">T</span><span class="elsevierStyleInf">1</span>, with later washout in the remaining sequences.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Escribano, M. Sentís, J.C. Oliva, L. Tortajada, M. Villajos, A. Martín, S. Ganau" "autores" => array:7 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Escribano" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Sentís" ] 2 => array:2 [ "nombre" => "J.C." "apellidos" => "Oliva" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "Tortajada" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Villajos" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Martín" ] 6 => array:2 [ "nombre" => "S." "apellidos" => "Ganau" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S003383381730187X" "doi" => "10.1016/j.rx.2017.10.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S003383381730187X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510717300757?idApp=UINPBA00004N" "url" => "/21735107/0000006000000001/v1_201802071944/S2173510717300757/v1_201802071944/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173510717300782" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2017.08.004" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "997" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2018;60:24-38" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6 "formatos" => array:2 [ "HTML" => 3 "PDF" => 3 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Update in Radiology</span>" "titulo" => "Multidetector computed tomography evaluation of candidates for transcatheter aortic valve implantation" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "24" "paginaFinal" => "38" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación de los pacientes candidatos a implante transcatéter de válvula aórtica mediante tomografía computarizada multidetector" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 2565 "Ancho" => 2500 "Tamanyo" => 324744 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Behavior of the aortic valve annulus throughout the cardiac cycle in a double oblique transverse reconstruction at 70 per cent of the R–R (diastole) and 20 per cent of the R–R (systole): the eccentricity of the aortic valve annulus decreases from the diastole to the systole due to an increase in the minimum diameter, remaining the maximum diameter more stable.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.E. Guillén Subirán, L.H. Ros Mendoza, E. Angulo Herviás, D. Yagüe Romeo, M.E. Núñez Motilva" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M.E." "apellidos" => "Guillén Subirán" ] 1 => array:2 [ "nombre" => "L.H." "apellidos" => "Ros Mendoza" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Angulo Herviás" ] 3 => array:2 [ "nombre" => "D." "apellidos" => "Yagüe Romeo" ] 4 => array:2 [ "nombre" => "M.E." "apellidos" => "Núñez Motilva" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S003383381730142X" "doi" => "10.1016/j.rx.2017.08.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S003383381730142X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510717300782?idApp=UINPBA00004N" "url" => "/21735107/0000006000000001/v1_201802071944/S2173510717300782/v1_201802071944/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Radiology through images</span>" "titulo" => "The role of imaging in the diagnosis of bronchiectasis: The key is in the distribution" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "39" "paginaFinal" => "48" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Bueno, L. Flors" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Bueno" "email" => array:1 [ 0 => "julianab@uchicago.edu" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Flors" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Imagen Cardiotorácica, Departamento de Radiología, Universidad de Chicago, Chicago, IL, United States" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Imagen Cardiotorácica, Departamento de Radiología e Imagen Médica, Universidad de Virginia, Charlottesville, VA, United States" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Papel de los estudios de imagen en el diagnóstico etiológico de las bronquiectasias: la distribución es la clave" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2900 "Ancho" => 2412 "Tamanyo" => 433535 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Illustrations of the different morphological types of bronchiectases. (B) Axial CT scan slices in two patients illustrating the different morphological types of bronchiectases: cylindrical bronchiectasis (arrowheads), varicose bronchiectasis (white arrow) and cystic bronchiectasis (hollow arrow).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Bronchiectases are a chronic inflammatory disease of the airways that involve dilation and progressive destruction of the brochial wall. Due to the little specificity of their clinical manifestations, such as chronic cough, recurrent respiratory infections, expectoration or hemoptysis, the imaging modalities play an important role in its diagnostic guide and treatment.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Chest X-ray is the initial study in patients presenting with respiratory symptoms.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">1</span></a> Recognizing the findings that characterize bronchiectases is esencial in their diagnostic algorythm. The computed tomography (CT) scan is the imaging modality of choice in the study of the airways,<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2–4</span></a> and specifically in the diagnosis of bronchiectases thanks to the anatomic information it provides, both of the airway and the lung parenchyma, and its high spatial resolution so needed if we want to visualize small bronchial structures. In addition, the CT scan can provide the keys to the etiological diagnosis of bronchiectases. CT protocols with low radiation doses allow its use in young patients and among the pediatric population.<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">5–7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The goal of this work is to describe the imaging findings of bronchiectases as well as their different types, to review the most common diseases that present this abnormality and to propose a diagnostic algorithm based on its anatomical distribution.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Definition, classification and imaging findings</span><p id="par0020" class="elsevierStylePara elsevierViewall">The term “bronchiectasis” is reserved to describe permanent localized or diffused dilation of the bronchi.<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">8–10</span></a> Bronchiectases usually occur due to chronic infectious processes; recurrent inflammation; obstruction of the bronchial lumen; or systemic diseases,<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">9,11</span></a> resulting in a vicious circle of infection and inflammation that alters the dynamics of the airways and the mucociliary transport, weakening the wall, making it collapse and promoting the retention of secretions.<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">12</span></a> In up to 50 per cent of the cases the cause is not identified.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The abnormal dilation of the bronchioles is called bronchiolectasis<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">8</span></a> and it is usually of inflammatory etiology, or secondary to pulmonary fibrosis.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Based on their macroscopic morphology, bronchiectases are categorized into three main groups<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">13</span></a>–cylindrical, varicose and cystic. Although this categorization has an excellent correlation with the bronchiectases morphology seen in the CT scans, its use is of little diagnostic utility,<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">14</span></a> since the different types usually coexist and they can be associated with more than just one disease:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0035" class="elsevierStylePara elsevierViewall">Cylindrical bronchiectasis consists of the uniform dilation of segmental brochi (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A and B), in most cases spreading to subsegmental branches.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0040" class="elsevierStylePara elsevierViewall">Varicose bronchiectases are characterized by the tortuosity of the affected bronchi, which, in addition to being dilated, have some sort of difuse pseudosaccular appearance (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A and B).</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0045" class="elsevierStylePara elsevierViewall">In cystic bronchiectasis, the bronchius acquires a rounded morphology forming spaces of cystic appearance that converge with one another in severe cases (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A and B) capable of simulating a “honeycombe” pattern.</p></li></ul></p><p id="par0050" class="elsevierStylePara elsevierViewall">“Traction bronchiectases” are a subtype of varicose bronchiectases that occur in pulmonary fibrosis.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Any of these types of bronchiectases can be associated with the thickening of the brochial walls and with mucoid impaction.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Chest X-ray findings are based on the severity and type of bronchiectasis.</p><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">We should remember that:</span> The “tram line” visualization of bronchial walls (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), and the peripheral tubular opacities branching out, with the “finger-in-glove” sign in cases of severe proximal bronchial dilation (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) are signs of bronchiectasis in the chest X-rays.<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">9,15</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">In the CT scan axial images, the recognition of an abnormal caliber of the bronchi is based on the association between the arterial and bronchial calibers. Both the arteries and the bronchi travel while wrapped up by the same connective tissue (axial interstice) toward the pulmonary periphery, and when they branch out, the proportion between both their calibers remains relatively constant. We should not forget that the lack of progressive bronchial tapering toward the pulmonary periphery, and one bronchio-arterial relation >1 in the CT scan axial slices, are useful if we want to determine the presence of bronchiectases in adults.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">16</span></a> One dilated bronchus adjacent to its arterial branch with a smaller caliber gives the appearance of the characteristic “signet-ring sign”<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2,8,13</span></a> (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><p id="par0075" class="elsevierStylePara elsevierViewall">In healthy people, bronchi are only visualized on the CT scan up to 2–3<span class="elsevierStyleHsp" style=""></span>cm of the pleural surface. The only structure of the secondary pulmonary lobule that is normally seen is the centrilobular artery.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">8</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">We should remember that:</span> visualization of the bronchi in the lung periphery is indicative of bronchiectasis.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">17</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">The thickening of bronchial walls; mucoid impactions; mosaic pattern; and air trapping are usually associated findings.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Etiologic diagnosis: the key is distribution</span><p id="par0090" class="elsevierStylePara elsevierViewall">The analysis of the regional distribution of bronchiectasis is the most useful diagnostic guide (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). They can be diffuse; central; or focal, and have a preference for apical, anterior or inferior pulmonary regions. Here is a look at them based on their regional distribution in order to facilitate the differential diagnosis.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Diffuse bronchiectasis</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Diffuse bronchiectasis with predominant apical involvement</span><p id="par0095" class="elsevierStylePara elsevierViewall">The most common disease in this group is cystic fibrosis. It is a recesive autosomal genetic disorder due to an alteration of the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It usually occurs in the pediatric age, with a wide spectrum of severity. Repeated respiratory infections and excessive production of sputum are the most common respiratory manifestations. Pancreatic failure and infertility are its most common systemic manifestations.<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">5,18</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Commonly, bronchiectases in cystic fibrosis are predominantly apical and peripheral, with damage of segmental and subsegmental bronchi in severe forms. Due to an abnormal mucociliary transport,<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">5</span></a> there is an extensive mucoid impaction in the affected bronchi, which can dilate greatly and adopt cylindrical or cystic forms (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A and B). Colonization by microorganisms such as <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span><a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a> is not uncommon, which can result in extensive scarring (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a><span class="elsevierStyleSmallCaps">C</span>).</p><p id="par0105" class="elsevierStylePara elsevierViewall">Bronchiectases in pulmonary sarcoidosis are seen in cases of severe interstitial fibrosis (stage 4) as traction bronchiectases<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">15,20</span></a> that mainly affect the superior lobes (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). Other associated findings characteristic of sarcoidosis are calcifications of hilar and mediastinal nodes, and perilymphatic nodes.<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a></p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Diffuse bronchiectasis of anterior predominant distribution</span><p id="par0110" class="elsevierStylePara elsevierViewall">Infection due to non-tuberculous mycobacteria usually affects the middle lobe and the lingula in middle-aged women with normal immunity with recurrent cough.<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">21,22</span></a> Bronchiectases are cylindrical and varicose, associated with bronchial thickening, mucus plugs and peribronchiovascular nodes (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">In the adult respiratory distress syndrome (ARDS), after its early inflammatory phase, the proliferation of fibroblasts results in pulmonary fibrosis.<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">23</span></a> Both the predominantly anterior distribution of fibrosis and traction bronchiectases seem to be due to the protective effect against the barotrauma exerted by consolidations, and the dependent atelectasis that characterize the early stages of ARDS.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">24</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Diffuse bronchiectasis of basal predominant distribution</span><p id="par0120" class="elsevierStylePara elsevierViewall">The ciliary dyskinesia syndrome is characterized by an abnormal mucociliary transport and it characteristically occurs with recurrent respiratory infections. The age of occurrence is variable, and patients can remain asymptomatic until adulthood.<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">21,25</span></a> Due to a generalized ciliary dysfunction, it is invariably associated with sinusitis and often with alterations in sperm motility and male infertility. The Kartagener syndrome, characterized by situs inversus, bronchiectases and sinusitis, occurs in approximately half the patients with ciliary dyskinesia. The findings of bronchiectasis both on the chest X-rays and the CT scans are similar to the ones reported in other diseases that occur with bronchiectases, yet damage is predominantly basal<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">26</span></a> (<a class="elsevierStyleCrossRef" href="#fig0030">Fig. 6</a>).</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">Aspiration bronchitis/bronchiolitis is a relatively misdiagnosed condition, but not an uncommon one. Patients with an altered mental status; dysfunction in their swallowing mechanism; or a history of neck neoplasms that may have required resection or radiotherapy are considered groups of risk. Due to the gravitational gradient, bronchiectases resulting from repeated microaspiration of gastric content are predominantly basal.<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">27,28</span></a> In addition to bronchiectases, bronchial thickening, mucoid impaction, “tree-in-bud” opacities, and subsegmental atelectasis are common findings too (<a class="elsevierStyleCrossRef" href="#fig0035">Fig. 7</a>).</p><elsevierMultimedia ident="fig0035"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Bronchiectases associated with pulmonary fibrosis in cases of usual interstitial pneumonia and nonspecific interstitial pneumonia are also predominantly basal and are characteristically traction bronchiectases<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">29</span></a> in the areas of fibrosis (<a class="elsevierStyleCrossRef" href="#fig0040">Fig. 8</a>).</p><elsevierMultimedia ident="fig0040"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Simliarly, basal predominance has been reported in idiopathic bronchiectases and bronchiectases associated with hypogammaglobulinemia and immunosuppression<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">30</span></a> (<a class="elsevierStyleCrossRefs" href="#fig0045">Figs. 9 and 10</a>).</p><elsevierMultimedia ident="fig0045"></elsevierMultimedia><elsevierMultimedia ident="fig0050"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">In patients with lung transplants, the development of bronchiolitis obliterans (BO) as a chronic dysfunction of the graft is well known and it occurs in up to 50 per cent of the cases.<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">31</span></a> It is an important cause of morbidity and mortality, and develops in approximately 12–18 months after the trasplant.<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">31,32</span></a> BO can also occur in patients with heart transplants<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">33</span></a>; in cases of graft versus host disease after hematopoietic stem cell trasplants; in occupational diseases, associated with systemic causes such as rheumatoid arthritis, or be of idiopathic nature.<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">34,35</span></a> Bronchiectases associated with BO are usually predominantly basal, cylindrical and symmetrical. At times, they are associated with thickening of bronchial walls and mosaic attenuation of the pulmonary parenchyma. The latter finding, due to areas of regional air trapping, can be seen through the CT scan expiratory images, although it is not always observed and its presence is not related to the severity of the disease.<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">31,32</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Diffuse bronchiectases without regional predominance</span><p id="par0145" class="elsevierStylePara elsevierViewall">Less common diseases presenting wiht abnormalities in the airway cartilage composition, such as the Mounier–Kuhn syndrome, and the Williams–Campbell syndrome present with diffuse bronchiectases without regional predominance. The Mounier–Kuhn syndrome, also known as tracheobronchomegaly, is characterized by the caliber widening of the upper airways, with a tracheal diameter >3<span class="elsevierStyleHsp" style=""></span>cm and main bronchi >2.4<span class="elsevierStyleHsp" style=""></span>cm on the CT scans.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">2,36</span></a> Also, the presence of pseudodiverticuli on the tracheobronquial walls is characteristic of this condition (<a class="elsevierStyleCrossRef" href="#fig0055">Fig. 11</a>). The Williams–Campbell syndrome characteristically affects fourth to sixth generation bronchi, keeping the central airways untouched<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">15</span></a> (<a class="elsevierStyleCrossRef" href="#fig0060">Fig. 12</a>).</p><elsevierMultimedia ident="fig0055"></elsevierMultimedia><elsevierMultimedia ident="fig0060"></elsevierMultimedia></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Bronchiectasis of central predominant distribution</span><p id="par0150" class="elsevierStylePara elsevierViewall">Allergic bronchopulmonary aspergillosis is characterized by large central bronchial dilations, with extensive mucus plugs and thick secretions, causing the classical “finger-in-glove” sign in the chest X-rays (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). On the CT scan, the bronchial content shows a characteristically high attenuation<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">17,37</span></a> (<a class="elsevierStyleCrossRef" href="#fig0065">Fig. 13</a>).</p><elsevierMultimedia ident="fig0065"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Focal bronchiectasis</span><p id="par0155" class="elsevierStylePara elsevierViewall">Unlike the causes of diffuse bronchiectases, the presence of focal bronchiectases is usually secondary to the obstruction of the bronchial lumen (due to tumor, inflammation, foreign body, or stenosis), with the subsequent distal dilation of the bronchus.</p><p id="par0160" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">We should remember that:</span> the study of focal bronchiectases requires bronchoscopic assessment in order to determine and treat the cause.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a> The “finger-in-glove” radiological sign, characterized by tubular opacity that may branch out, describes the appearance of focal bronchiectases occurring in cases of bronchial atresia, postinfectious bronchial stenosis, or secondary to a foreign body in a lobar or segmental bronchus. This type of bronchiectasis is also known as “bronchocele”,<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">8</span></a> since these disorders result in the retention of secretion and the significant dilation of the affected bronchus (<a class="elsevierStyleCrossRef" href="#fig0070">Fig. 14</a>).</p><elsevierMultimedia ident="fig0070"></elsevierMultimedia><p id="par0165" class="elsevierStylePara elsevierViewall">Some inflammatory or infectious processes may cause focal bronchiectases, as it is the case with radiotherapy fibrosis. Traction bronchiectases appear close to the irradiated area as a result of pulmonary fibrosis.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a> Also, the scarring process of infections such as tuberculosis in any of its stages, and specifically bronchial tuberculosis, is associated with bronchial wall damage and fibrosis, and results in bronchiectases.<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">38</span></a> Since the bacillus tha causes tuberculosis has a preference for pulmonary apices, this type of post-tuberculous bronchiectases has a focal apical distribution (<a class="elsevierStyleCrossRef" href="#fig0075">Fig. 15</a>).</p><elsevierMultimedia ident="fig0075"></elsevierMultimedia></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conclusions</span><p id="par0170" class="elsevierStylePara elsevierViewall">Bronchiectases are a common finding and they can be the result of a broad range of diseases, including congenital; infectious; inflammatory; systemic; and iatrogenic conditions. Imaging modalities play a crucial role in their detection and classification. Specifically, the analysis of its distribution through CT scans allows diagnostic guidance of the underlying disease.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Ethical disclosures</span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Protection of human and animal subjects</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that no experiments with human beings or animals have been performed while conducting this investigation.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Confidentiality of data</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors confirm that in this article there are no data from patients.</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Right to privacy and informed consent</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors confirm that in this article there are no data from patients.</p></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Authors contribution</span><p id="par0190" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">1.</span><p id="par0195" class="elsevierStylePara elsevierViewall">Manager of the integrity of the study: JB and LF.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">2.</span><p id="par0200" class="elsevierStylePara elsevierViewall">Study Idea: JB and LF.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">3.</span><p id="par0205" class="elsevierStylePara elsevierViewall">Study Design: JB and LF.</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">4.</span><p id="par0210" class="elsevierStylePara elsevierViewall">Data Mining: JB and LF.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">5.</span><p id="par0215" class="elsevierStylePara elsevierViewall">Data Analysis and Interpretation: JB and LF.</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">6.</span><p id="par0220" class="elsevierStylePara elsevierViewall">Statistical Analysis: N/A.</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">7.</span><p id="par0225" class="elsevierStylePara elsevierViewall">Reference: JB and LF.</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">8.</span><p id="par0230" class="elsevierStylePara elsevierViewall">Writing: JB and LF.</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">9.</span><p id="par0235" class="elsevierStylePara elsevierViewall">Critical review of the manuscript with intellectually relevant remarks: JB and LF.</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">10.</span><p id="par0240" class="elsevierStylePara elsevierViewall">Approval of final version: JB and LF.</p></li></ul></p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflict of interest</span><p id="par0245" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres976642" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec946416" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres976643" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec946415" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Definition, classification and imaging findings" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Etiologic diagnosis: the key is distribution" "secciones" => array:3 [ 0 => array:3 [ "identificador" => "sec0020" "titulo" => "Diffuse bronchiectasis" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Diffuse bronchiectasis with predominant apical involvement" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Diffuse bronchiectasis of anterior predominant distribution" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Diffuse bronchiectasis of basal predominant distribution" ] 3 => array:2 [ "identificador" => "sec0040" "titulo" => "Diffuse bronchiectases without regional predominance" ] ] ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Bronchiectasis of central predominant distribution" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "Focal bronchiectasis" ] ] ] 7 => array:2 [ "identificador" => "sec0055" "titulo" => "Conclusions" ] 8 => array:3 [ "identificador" => "sec0060" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0065" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0070" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0075" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0080" "titulo" => "Authors contribution" ] 10 => array:2 [ "identificador" => "sec0085" "titulo" => "Conflict of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-01-31" "fechaAceptado" => "2017-06-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec946416" "palabras" => array:5 [ 0 => "Bronchiectasis" 1 => "Bronchial dilation" 2 => "Cystic fibrosis" 3 => "Bronchitis" 4 => "Chronic bronchitis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec946415" "palabras" => array:5 [ 0 => "Bronquiectasia" 1 => "Dilatación bronquial" 2 => "Fibrosis quística" 3 => "Bronquitis" 4 => "Bronquitis crónica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Diseases that involve the medium caliber airways (segmental and subsegmental bronchi) are common and present clinically with nonspecific respiratory symptoms such as cough, recurrent respiratory infections and occasionally, hemoptysis. The abnormal and irreversible dilation of bronchi is known as “bronchiectasis”. The diagnosis can be challenging and the analysis of the regional distribution of the bronchiectasis is the most useful diagnostic guide. The objective of this manuscript is to describe the main imaging findings of bronchiectasis and their classification, review the diseases that most commonly present with this abnormality, and provide an approach to the diagnosis based on their imaging appearance and anatomic distribution. Bronchiectasis is a frequent finding that may result from a broad range of disorders. Imaging plays a paramount role in diagnosis, both in the detection and classification, and in the diagnosis of the underlying pathology.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La patología de las vías respiratorias de medio calibre (bronquios segmentarios y subsegmentarios) es común y se presenta con síntomas respiratorios poco específicos, como tos, infecciones de repetición y en ocasiones hemoptisis. La dilatación permanente del árbol bronquial se conoce como «bronquiectasia» y representa un reto diagnóstico. El análisis de la distribución regional de las bronquiectasias en los diferentes lóbulos pulmonares es la guía diagnóstica más útil. El objetivo de este trabajo es describir los hallazgos de imagen de las bronquiectasias y sus diferentes tipos, revisar las situaciones más comunes y proponer un algoritmo diagnóstico basado en su distribución anatómica. Las bronquiectasias son un hallazgo frecuente, resultado de un amplio espectro de enfermedades. Los estudios de imagen desempeñan un papel esencial en su detección, clasificación y orientación diagnóstica hacia la patología subyacente.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Bueno J, Flors L. Papel de los estudios de imagen en el diagnóstico etiológico de las bronquiectasias: la distribución es la clave. Radiología. 2018:60;39–48.</p>" ] ] "multimedia" => array:16 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2900 "Ancho" => 2412 "Tamanyo" => 433535 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Illustrations of the different morphological types of bronchiectases. (B) Axial CT scan slices in two patients illustrating the different morphological types of bronchiectases: cylindrical bronchiectasis (arrowheads), varicose bronchiectasis (white arrow) and cystic bronchiectasis (hollow arrow).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 807 "Ancho" => 2533 "Tamanyo" => 190775 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Twenty-three-year-old male with cystic fibrosis. (A) The chest X-ray shows extensive bronchial thickening, and “tramline” opacities predominantly in the superior lobes, secondary to bronchiectasis (arrows). The abnormal convexity of the aortopulmonary window (arrowhead) is due to associated mediastinal adenopathies. (B) Axial CT scan image confirming the existence of extensive cylindrical bronchiectases, mainly segmental and subsegmental (arrows). (C) Coronal CT reconstruction in another paciente with cystic fibrosis complicated with recurrent infections showing great distortion of lung architecture due to severe fibrosis and formation of bullae and apical cystic cavities (asterisks).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 926 "Ancho" => 1867 "Tamanyo" => 160098 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(A) Axial CT scan image showing “signet-ring sign” characterized by the abnormal proportion between arterial (arrowhead) and bronchial diameter (arrow) defining the presence of bronchiectasis. This sign takes its name because its appearance is similar to a ring and its stone (illustration). (B) Posteroanterior chest X-ray showing the “finger-in-glove” sign, characterized by one tubular opacity branching out (arrows) due to mucoid impaction and severe bronchial dilation.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 873 "Ancho" => 2534 "Tamanyo" => 157120 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Fifty-eight-year-old male with a history of pulmonary sarcoidosis. The posteroanterior chest X-ray (A) and the Coronal CT reconstruction (B) show the characteristic distortion of the pulmonary parenchyma secondary to advanced sarcoidosis. There is traction bronchiectasis (arrows) and apical cavities (asterisks) due to severe fibrotic changes. The axial CT scan image (C) shows solid and partially calcified masses within the cavities representative of mycetomas (arrows) due to saprophytic colonization by <span class="elsevierStyleItalic">Aspergillus</span>.</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 883 "Ancho" => 1300 "Tamanyo" => 127435 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fifty-eight-year-old woman with chronic cough of several years duration. The axial CT scan image shows diffuse bronchial thickening and segmental and subsegmental cylindrical bronchiectases in the middle lobe and the lingula (arrows). This distribution is characteristic of chronic infection due to nontuberculous mycobacteria.</p>" ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 851 "Ancho" => 2534 "Tamanyo" => 208445 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Forty-three-year-old male with a history of sinusitis, recurrent pneumonias and infertility. (A) The coronal CT scan image of paranasal sinuses shows extensive occupation of the maxillary sinuses (asterisks) and the ethmoidal air cells due to mucoid material. The bony walls of paranasal sinuses are intact. (B) The posteroanterior chest X-ray shows heterogeneous opacities in both pulmonary bases, predominantly in the left one. There are tubular transparencies and bronchial thickening, indicative of bronchiectasis (circle). (C) The axial CT scan image confirms the presence of bronchial thickening and dilation (arrows) in the inferior left lobe, and bronchiolectasis (arrowheads) due to distal bronchiolar damage.</p>" ] ] 6 => array:7 [ "identificador" => "fig0035" "etiqueta" => "Figure 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 1076 "Ancho" => 1300 "Tamanyo" => 153530 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Sixty-seven-year-old male with a history of hiatal hernia and recurrent pneumonias. The axial CT scan image shows cystic bronchiectasis (arrows) with basal distribution, secondary to recurrent aspiration. There is circumferential thickening and dilation of distal esophagus (asterisk).</p>" ] ] 7 => array:7 [ "identificador" => "fig0040" "etiqueta" => "Figure 8" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr8.jpeg" "Alto" => 1057 "Ancho" => 1300 "Tamanyo" => 205339 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Sixty-three-year-old male with a history of idiopathic pulmonary fibrosis confirmed through lung biopsy. The high-resolution axial CT scan image shows bronchiectasis and traction bronchiolectasis (arrows) of a varicose morphology and secondary to underlying advanced pulmonary fibrosis, in this case being a usual interstitial pneumonia characterized by extensive subpleural reticulation and areas of basal honeycombing (arrowheads).</p>" ] ] 8 => array:7 [ "identificador" => "fig0045" "etiqueta" => "Figure 9" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr9.jpeg" "Alto" => 975 "Ancho" => 975 "Tamanyo" => 95092 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Forty-eight-year-old male with a history of chronic cough and recurrent pneumonia. The axial CT scan image shows consolidation and cystic bronchiectases in the middle lobe (arrows). There is also thickening of bronchial walls, centrilobular micronodes and “tree-in-bud” opacities (circle) in the lower right lobe due to multilobar condition.</p>" ] ] 9 => array:7 [ "identificador" => "fig0050" "etiqueta" => "Figure 10" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr10.jpeg" "Alto" => 1067 "Ancho" => 1867 "Tamanyo" => 205330 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Forty-seven-year-old male with a history of Crohn's disease with chronic cough. (A) Lateral chest X-ray showing bronchial thickening and partial volume loss in the middle lobe (arrowheads). We can see tubular “tramline” opacities (arrow), indicative of bronchiectasis. (B) The axial CT scan image confirms the radiographic findings. There is diffuse thickening of bronchial walls, yet the presence of bronchiectasis is limited to the middle lobe.</p>" ] ] 10 => array:7 [ "identificador" => "fig0055" "etiqueta" => "Figure 11" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr11.jpeg" "Alto" => 574 "Ancho" => 1299 "Tamanyo" => 109666 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Mounier–Kuhn syndrome. Axial CT scan images in two patients showing great increase of tracheal diameter (arrows), dilation and pseudosacculations of the central bronchial walls (arrows), and generalized cylindrical bronchiectasis (arrowheads).</p>" ] ] 11 => array:7 [ "identificador" => "fig0060" "etiqueta" => "Figure 12" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr12.jpeg" "Alto" => 923 "Ancho" => 1212 "Tamanyo" => 147081 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Forty-nine-year-old woman with a history of chronic cough and recurrent respiratory infections. Axial CT scan image showing diffuse thickening of bronchial walls, and varicoid (white arrow) and cystic bronchiectasis (arrowhead) affecting the segmental and subsegmental bronchi. There are central bronchial pseudosacculations (hollow arrow), but the main bronchi and the tracheal caliber are normal. This set of findings is characteristic of the Williams–Campbell syndrome.</p>" ] ] 12 => array:7 [ "identificador" => "fig0065" "etiqueta" => "Figure 13" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr13.jpeg" "Alto" => 803 "Ancho" => 1724 "Tamanyo" => 164814 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Forty-three-year-old woman with a history of asthma complicated with allergic bronchopulmonary aspergillosis. (A) Coronal CT reconstruction showing bronchiectasis and mucoid impactions with “glove-in-finger” appearance in both inferior lobes (arrows). (B) The axial image in a mediastinal window setting shows high density (54<span class="elsevierStyleHsp" style=""></span>HU, arrows) in the lumen of bronchiectasis – a characteristic finding of allergic bronchopulmonary aspergillosis.</p>" ] ] 13 => array:7 [ "identificador" => "fig0070" "etiqueta" => "Figure 14" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr14.jpeg" "Alto" => 541 "Ancho" => 1900 "Tamanyo" => 119549 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Thirty-one-year-old asymptomatic male. Coronal reconstruction (A) and axial CT scan slice (B) showing focal bronchiectasis with mucoid impaction in a characteristic “finger-in-glove” image in the upper left lobe (arrows), distal to bronchial atresia (arrowhead). (C) Axial image with contrast manipulation in the lung window in order to highlight segmental hypodensity secondary to trapping distal to the obstruction of the atrophied bronchus (encircled area).</p>" ] ] 14 => array:7 [ "identificador" => "fig0075" "etiqueta" => "Figure 15" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr15.jpeg" "Alto" => 903 "Ancho" => 1866 "Tamanyo" => 115184 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Twenty-five-year-old male with a history of tuberculosis treated during childhood; currently asymptomatic. (A) The posteroanterior chest X-ray shows cicatricial atelectasis with loss of upper left lobe volume and pulmonary hilum upper retraction (arrows). There is associated pleural apical thickening (arrowhead). (B) Coronal CT reconstruction in minimum intensity projection (MinIP) showing cylindrical bronchiectases (arrow) associated with total volume loss of the superior left lobe. There is compensatory expansion of right lung that shows areas of lesser attenuation (asterisks), indicative of air trapping, probably due to post-infectious bronchiolitis.</p>" ] ] 15 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diffuse bronchiectases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Apical predominance \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Cystic fibrosis<br>• Sarcoidosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Anterior predominance \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Infection due to nontuberculous mycobacteria<br>• Adult respiratory distress syndrome \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Basal predominance \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Chronic aspiration sequelae<br>• Ciliary dyskinesia<br>• Pulmonary fibrosis<br>• Immunosuppression-associated bronchiectasis<br>• Bronchiolitis obliterans \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Without regional predominance \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Mounier–Kuhn syndrome<br>• Williams–Campbell syndrome \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Central Bronchiectases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Allergic bronchopulmonary aspergillosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal Bronchiectases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Post-radiotherapy fibrosis<br>• Tuberculosis sequelae<br>• Bronchial atresia<br>• Extrinsic compression<br>• Foreign body<br>• Endobronchial neoplasm<br>• Bronchial stenosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1654388.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Classification of bronchiectases based on their distribution.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib0195" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ACR Appropriateness Criteria<span class="elsevierStyleSup">®</span> acute respiratory illness in immunocompetent patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. 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