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array:24 [ "pii" => "S2173510717300642" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2017.10.001" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "995" "copyright" => "SERAM" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2017;59:511-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1 "HTML" => 1 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0033833817301352" "issn" => "00338338" "doi" => "10.1016/j.rx.2017.08.002" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "995" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2017;59:511-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 540 "formatos" => array:3 [ "EPUB" => 1 "HTML" => 288 "PDF" => 251 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Caracterización de cánceres de mama sintomáticos invisibles en mamografía digital y tomosíntesis: correlación radiopatológica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "511" "paginaFinal" => "515" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Characterization of invisible breast cancers in digital mammography and tomosynthesis: radio-pathological correlation" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 481 "Ancho" => 1500 "Tamanyo" => 86743 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">a) Exploración ecográfica en la que se identificó un nódulo hipoecogénico de bordes mal definidos cercano a la unión de los cuadrantes externos de la mama derecha. b) RM mamaria: imagen coronal en la que se visualizó un realce tipo masa (15<span class="elsevierStyleHsp" style=""></span>mm) correspondiente al nódulo descrito en la ecografía.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P.M. 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"apellidos" => "Cruz Hernández" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173510717300642" "doi" => "10.1016/j.rxeng.2017.10.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510717300642?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833817301352?idApp=UINPBA00004N" "url" => "/00338338/0000005900000006/v1_201711120018/S0033833817301352/v1_201711120018/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173510717300654" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2017.10.002" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "984" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2017;59:516-22" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2 "HTML" => 2 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Report</span>" "titulo" => "Value of intraoperative ultrasound with conventional probes and its usefulness in surgical and therapeutic management of patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "516" "paginaFinal" => "522" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Valor de la ecografía intraoperatoria realizada con sondas convencionales y su utilidad en el manejo quirúrgico y terapéutico de los pacientes" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2234 "Ancho" => 1645 "Tamanyo" => 114108 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Bar graph showing the matches between the intraoperative ultrasound scan and the histological findings, and pie chart showing the matches between the intraoperative ultrasound scan and the preoperative imaging modalities.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.M. Novo Amado, M. Fraga Sánchez, J. González Ramírez, G. Calvo Arrojo, C. Vidal Cameán, J.M. Crespo Teijeiro" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A.M." "apellidos" => "Novo Amado" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Fraga Sánchez" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "González Ramírez" ] 3 => array:2 [ "nombre" => "G." "apellidos" => "Calvo Arrojo" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Vidal Cameán" ] 5 => array:2 [ "nombre" => "J.M." "apellidos" => "Crespo Teijeiro" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0033833817301029" "doi" => "10.1016/j.rx.2017.06.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0033833817301029?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173510717300654?idApp=UINPBA00004N" "url" => "/21735107/0000005900000006/v1_201711202321/S2173510717300654/v1_201711202321/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173510717300538" "issn" => "21735107" "doi" => "10.1016/j.rxeng.2017.07.004" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "970" "copyright" => "SERAM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Radiologia. 2017;59:504-10" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Radiology through images</span>" "titulo" => "Usefulness of magnetic resonance imaging in the postsurgical assessment of patients with inflatable penile prostheses" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "504" "paginaFinal" => "510" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilidad de la resonancia magnética en la valoración postquirúrgica de pacientes con prótesis hidráulica de pene" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1887 "Ancho" => 1417 "Tamanyo" => 164318 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Fifty-eight-year-old male with persistent pain in the perineal region, and a history of penile prosthesis implantation. The T2-weighted sequences show left cylinder (LC) posterior extremity migration located outside the corpus cavernosum reaching out to the perineal fat (arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Pacheco Usmayo, A. Torregrosa Andrés, J. Flores Méndez, S. Luján Marco, R. Rogel Bertó" "autores" => array:5 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Pacheco Usmayo" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Torregrosa Andrés" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Flores Méndez" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Luján Marco" ] 4 => array:2 [ "nombre" => "R." 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Aguilar Angulo, C. Romero Castellano, J. Ruiz Martín, M.P. Sánchez-Camacho González-Carrato, L.M. Cruz Hernández" "autores" => array:5 [ 0 => array:4 [ "nombre" => "P.M." "apellidos" => "Aguilar Angulo" "email" => array:1 [ 0 => "elaguilapm@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Romero Castellano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Ruiz Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M.P." "apellidos" => "Sánchez-Camacho González-Carrato" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "L.M." "apellidos" => "Cruz Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Sección de Radiología Mamaria, Servicio de Radiodiagnóstico, Hospital Virgen de la Salud, Complejo Hospitalario de Toledo, Toledo, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Virgen de la Salud, Complejo Hospitalario de Toledo, Toledo, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Caracterización de cánceres de mama sintomáticos invisibles en mamografía digital y tomosíntesis: correlación radiopatológica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 801 "Ancho" => 1300 "Tamanyo" => 84246 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fifty (50) year old female with indurated area in the outer quadrants of her right breast. 2D digital mammogram of her breast in (a) craniocaudal and (b) lateral projections, of heterogeneous density without findings (BI-RADS 1).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Breast tomosynthesis (TS) is an important contributor in the diagnostic process of breast cancer. Various studies have confirmed the advantages of using it together with mammograms in programs of population screening (improving the detection of cancer with fewer recitations<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1–4</span></a>), and in the pathological setting (improving the sensitivity, characterization, and categorization of the lesions,<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5,6</span></a> with a lower percentage of findings classified BI-RADS 3,<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> among other).</p><p id="par0010" class="elsevierStylePara elsevierViewall">However, it is not a perfect modality and although it allows us to assess areas where possible lesions may be misdiagnosed in the digital mammograms (DM), at times, breast cancer can remain invisible in the DM and the TS. Since it is more and more widely used, we need to know more about the advantages and limitations of TS (information on true false negatives in both modalities in medical literature is scarce).</p><p id="par0015" class="elsevierStylePara elsevierViewall">The goal of this work was to analyze the radiopathological characteristics of lesions with histologic diagnosis of breast cancer (detected in patients with breast symptoms) hidden in the DM and the TS.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">It is a retrospective study approved by our hospital ethics committee and focused on the descriptive analysis of hidden lesions in the DM and the TS with a histological diagnosis of breast cancer in patients with clinical suspicion. Out of the 387 female patients (both from the early detection program of our hospital and those with breast symptoms) with a diagnosis of breast cancer who were studied using DMs and TS as initial tests in the Breast Radiology Unit between Nov. 2011 and Dec. 2015, 160 patients with symptoms were selected (symptoms such as palpable nodules or indurations; changes in breast size or morphology; retraction or sinking of the nipple skin; nipple discharges, skin abnormalities; presence of axillary adenopathies; and even persistent mastodynia).</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patients were studied using the Selenia Dimensions system (Hologic, Bedford, MA, USA). The protocol used was the COMBO mode capable of acquiring 2D images and one tomosynthesis in one single compression; craniocaudal and mediolateral oblique projections were taken for every breast. As part of the diagnostic process, all cases underwent ultrasound scans with a 12<span class="elsevierStyleHsp" style=""></span>MHz linear probe (Aplio MX, Toshiba Medical Systems, Tokyo, Japan); MRIs (RM de 1.5 T Avanto, Siemens, Erlangen, Germany); the acquisition of images included T1 and T2-weighted enhanced sequences, and diffusion and dynamic studies after the administrations of gadolinium; and percutaneous biopsies (low ultrasonography with a 14<span class="elsevierStyleHsp" style=""></span>G tru-cut needle) as additional tests prior to surgical exeresis.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The images acquired and anonymized were part of a database that was reviewed by three (3) different radiologists with exclusive dedication (professional experience of 2–15 years) and a computed assisted detection system was used. Information such as age; clinical presentation; type of breast density; the BI-RADS category, and the number and type of lesions was gathered as well, and the lesions hidden in the DMs and TS were identified (true false negatives) having, as a reference point, the anatomopathological findings and the MRI findings (misreadings or technical mistakes were discarded). Eventually, the imaging findings of the lesions selected were consistent with their respective histopathological diagnoses.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">Overall, 169 neoplastic lesions were found in the symptomatic group, and out of all these lesions, seven (7) were selected (4 per cent) in which breast cancer was not visible through the DM or the TS (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>, Appendix B video 1–2). Two (2) lesions of our series were found in different quadrants of the same breast (multicentric affectation). The patients’ average age was 47 years old (range: 32–61 years old), and the associated symptoms were self-palpation of an area with greater consistency, or a nodule <span class="elsevierStyleItalic">de novo</span>. When it comes to breast density, four (4) lesions were found in high-density breasts (types c and d), and the rest in type b density breasts (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">When it comes to the remaining imaging modalities, six (6) carcinomas were seen in the ultrasound scan (looking as hypoechogenic masses of irregular BI-RADS 4 morphology), and in the MRI (mass enhancement with type 2 uptake curves, and average ADC map of 0.68<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−3</span><span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>/s [they varied from 0.61 to 0.78<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−3</span><span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>/s]) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Only one (1) lesion was not detected in the ultrasound scan, but it was identified in the MRI as segmental enhancement (this case was the aforementioned multicenter affectation). In the MRI tumor size was close to 1<span class="elsevierStyleHsp" style=""></span>cm in three (3) cases (43 per cent), and >3<span class="elsevierStyleHsp" style=""></span>cm in the remaining cases (57 per cent). In two (2) small lesions, conservative surgery was performed, and the size of the final piece had a minimal variation (1–2<span class="elsevierStyleHsp" style=""></span>mm) with respect to the size measure through the MRI; the rest of the group received neoadjuvant therapy prior to exeresis.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">All neoplasms were infiltrating ductal carcinomas (IDC), four (4) of them were grade 2 tumors according to the Nottingham grading system (moderately differentiated) and two (2) were grade 3 tumors (poorly differentiated). All biopsies (except for one lesion) confirmed high percentages of tumor stroma with respect to neoplastic cellularity (55–70 per cent). With respect to the molecular subtypes surrogate to immunohistochemical markers, only one (1) of the cases was triple negative and the rest were luminal category tumors (5 were luminal B like tumors, and 1 was a luminal A like tumor).</p><p id="par0050" class="elsevierStylePara elsevierViewall">Finally, the tumor margins of the two (2) lesions were intervened without prior chemotherapy. Both were moving masses that did not infiltrate the adjacent breast parenchyma (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Lesions were surrounded by fibrous tissue, or benign proliferative changes (sclerosing adenosis) without direct contact with neighboring fat.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">The TS is a modality that, when combined with mammograms, contributes to the detection and characterization of breast cancer. However, this modality has some limitations, and some lesions still do not differentiate breast parenchyma from the rest. According to the medical literature, the rate of false negatives in conventional mammograms goes from 8 to 10 per cent up to 35 per cent,<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">8,9</span></a> and some of the causes may be high breast density; a poor technique; perception errors; or incorrect interpretations, among others.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> One of the great contributions of TS is that it helps reduce the effect of structure overlapping, improves visualization and reveals new findings.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> Yet despite all these advantages, in our series we found a small percentage (4 per cent) of false negative lesions in the DM and the TS in the group of symptomatic patients after ruling out all possible interpretation errors, and technical mistakes due to our study inclusion criteria.</p><p id="par0060" class="elsevierStylePara elsevierViewall">When it comes to breast density, 57 per cent of the lesions occurred in high-density breasts, and the remaining ones in low-density breasts (type b). This was probably due to the fact that there are several factors that may have influenced tumor visualization, such as the presence of a fat plane separating the lesion from the neighboring parenchyma<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a>; the location of the tumor in an area of higher density with respect to the rest of the parenchyma that eclipses the lesion<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a>; or the presence of other signs of suspicion associated with the lesions, such as distortions or microcalcifications, that are necessary for their identification.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">11,13</span></a> Not a single carcinoma showed other signs suggestive of malignancy, and 86 per cent of the masses were undistinguishable from breast tissue in the DMs and TS, with BI-RADS 4 semiological data in the ultrasound scan and the MRI. In our own experience, small size would not be a characteristic of false negatives in DMs and TS with associated clinical presentations, since the size of most of these false negatives (57 per cent) was ≥3<span class="elsevierStyleHsp" style=""></span>cm, and all cases (except for one lesion only detected through an MRI) were clinically evident.</p><p id="par0065" class="elsevierStylePara elsevierViewall">With respect to the anatomopathological findings, all neoplasms of our series were infiltrating ductal carcinomas (most hidden carcinomas were poorly or moderately differentiated). With respect to the molecular classification, only one (1) lesion was categorized as a triple negative carcinoma and the rest were luminal neoplasms (most luminal B tumors), something that we also saw in our series.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> This finding would indicate that, when it comes to immunophenotyping, neoplasms misdiagnosed in the DM and the TS would have worse prognosis.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Our study has some limitations such as the low number of hidden lesions, which makes it hard to draw definitive conclusions, the group selected for the analysis (symptomatic neoplasms where the findings reported could only be compared to this group), and the type of study (retrospective, without case follow-up).</p><p id="par0075" class="elsevierStylePara elsevierViewall">In sum, false negative symptomatic carcinomas in the DM and TS of our small series were basically masses; all lesions were diagnosed as infiltrating ductal carcinomas (predominantly immunophenotype luminal B tumors); and they were identified in breasts with densities types b, c, and d. We need further studies to specifically analyze the impact of false negatives in diagnostic and screening programs of breast cancer that use digital mammograms and TS, with a special attention to their possible causes.</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Ethical disclosures</span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Protection of human and animal subjects</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation.</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Confidentiality of data</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article.</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Right to privacy and informed consent</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Authors</span><p id="par0080" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1.</span><p id="par0085" class="elsevierStylePara elsevierViewall">Manager of the integrity of the study: PMAA, CRC.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2.</span><p id="par0090" class="elsevierStylePara elsevierViewall">Study idea: PMAA, CRC, JRM, MPSCGC, LMCH.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3.</span><p id="par0095" class="elsevierStylePara elsevierViewall">Study design: PMAA, CRC, JRM.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4.</span><p id="par0100" class="elsevierStylePara elsevierViewall">Data mining: PMAA, JRM, MPSCGC, LMCH.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5.</span><p id="par0105" class="elsevierStylePara elsevierViewall">Data analysis and interpretation: PMAA, CRC, JRM.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6.</span><p id="par0110" class="elsevierStylePara elsevierViewall">Statistical analysis: PMAA, CRC, JRM.</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">7.</span><p id="par0115" class="elsevierStylePara elsevierViewall">Reference: PMAA, MPSCGC, LMCH.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">8.</span><p id="par0120" class="elsevierStylePara elsevierViewall">Writing: PMAA, CRC, JRM.</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">9.</span><p id="par0125" class="elsevierStylePara elsevierViewall">Critical review of the manuscript with intellectually relevant remarks: PMAA, CRC, JRM, MPSCGC, LMCH.</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">10.</span><p id="par0130" class="elsevierStylePara elsevierViewall">Approval of final version: PMAA, CRC, JRM, MPSCGC, LMCH.</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of interests</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests associated with this article whatsoever.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres942186" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec915111" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres942187" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec915110" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:3 [ "identificador" => "sec0080" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0085" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0090" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0095" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0025" "titulo" => "Authors" ] 10 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interests" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-02-09" "fechaAceptado" => "2017-08-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec915111" "palabras" => array:4 [ 0 => "Occult breast carcinoma" 1 => "False negative" 2 => "Digital mammography" 3 => "Digital breast tomosynthesis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec915110" "palabras" => array:4 [ 0 => "Carcinoma de mama oculto" 1 => "Falso negativo" 2 => "Mamografía digital" 3 => "Tomosíntesis mamaria digital" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To review the radio-pathologic features of symptomatic breast cancers not detected at digital mammography (DM) and digital breast tomosynthesis (DBT).</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Retrospective analysis of 169 lesions from symptomatic patients with breast cancer that were studied with DM, DBT, ultrasound (US) and magnetic resonance (MR). We identified occult lesions (true false negatives) in DM and DBT. Clinical data, density, US and MR findings were analyzed as well as histopathological results.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We identified seven occult lesions in DM and DBT. 57 per cent (4/7) of the lesions were identified in high-density breasts (type c and d), and the rest of them in breasts of density type b. Six carcinomas were identified at US and MR (BI-RADS 4 masses); the remaining lesion was only identified at MR. The tumor size was larger than 3<span class="elsevierStyleHsp" style=""></span>cm at MRI in 57 per cent of the lesions. All tumors were ductal infiltrating carcinomas, six of them with high stromal proportion. According to molecular classification, we found only one triple-negative breast cancer, the other lesions were luminal-type. We analyzed the tumor margins of two resected carcinomas that were not treated with neoadjuvant chemotherapy, both lesions presented margins that displaced the adjacent parenchyma without infiltrating it.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Occult breast carcinomas in DM and DBT accounted for 4 per cent of lesions detected in patients with symptoms. They were mostly masses, all of them presented the diagnosis of infiltrating ductal carcinoma (with predominance of the luminal immunophenotype) and were detected in breasts of density type b, c and d.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Revisar las características radiopatológicas de carcinomas mamarios sintomáticos ocultos en mamografía digital (MD) y tomosíntesis (TS).</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Análisis retrospectivo de 169 lesiones provenientes de pacientes sintomáticas con diagnóstico histológico de cáncer de mama y que fueron estudiadas con MD, TS, ecografía y resonancia magnética (RM). Se identificaron las lesiones ocultas (falsos negativos verdaderos) en MD y TS. Se analizaron datos clínicos, de densidad, los hallazgos con ecografía y RM, y la histopatología de las lesiones.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se detectaron siete lesiones neoplásicas ocultas en MD y TS. El 57% (4/7) se presentó en mamas densas (tipo c y d), y las restantes en mamas de densidad b. Se identificaron seis de los carcinomas por ecografía y RM (masas BI-RADS 4); la lesión restante solo se visualizó en RM. En el 57% de las neoplasias, el tamaño medido con RM fue mayor de 3<span class="elsevierStyleHsp" style=""></span>cm. Todas fueron carcinomas ductales infiltrantes, seis de ellos con alta proporción estromal. En cuanto a los subtipos moleculares, solo una fue triple negativo y las demás fueron de tipo luminal. Se analizaron los márgenes tumorales de dos carcinomas intervenidos sin quimioterapia previa, y ambos presentaban márgenes que desplazaban sin infiltrar el parénquima adyacente.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los carcinomas ocultos en MD y TS representaron el 4% de las lesiones detectadas en pacientes sintomáticas, fueron mayoritariamente masas, todas tuvieron diagnóstico de carcinoma ductal infiltrante (con predominio del inmunofenotipo luminal) y se detectaron en mamas de densidad tipo b, c y d.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as: Aguilar Angulo PM, Romero Castellano C, Ruiz Martín J, Sánchez-Camacho González-Carrato MP, Cruz Hernández LM. Caracterización de cánceres de mama sintomáticos invisibles en mamografía digital y tomosíntesis: correlación radiopatológica. Radiología. 2017;59:511–515.</p>" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0145" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article:</p> <p id="par0150" class="elsevierStylePara elsevierViewall">Video 1–2. Tomosynthesis in craniocaudal and lateral projections of the patient from <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>; there are no suspicious signs or other significant findings in either of the two (2) cases.<elsevierMultimedia ident="upi0005"></elsevierMultimedia><elsevierMultimedia ident="upi0010"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0040" ] ] ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 801 "Ancho" => 1300 "Tamanyo" => 84246 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fifty (50) year old female with indurated area in the outer quadrants of her right breast. 2D digital mammogram of her breast in (a) craniocaudal and (b) lateral projections, of heterogeneous density without findings (BI-RADS 1).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 481 "Ancho" => 1500 "Tamanyo" => 85975 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">(a) Ultrasound scan showing one (1) hypoechogenic nodule of poorly established edges close to the patient's right breast external quadrant juncture. (b) Breast MRI: coronal image showing mass enhancement (15<span class="elsevierStyleHsp" style=""></span>mm) consistent with the nodule described by the ultrasounds scan.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1099 "Ancho" => 950 "Tamanyo" => 237149 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Histology of the studied lesion (after surgical exeresis), with a diagnosis of well-differentiated infiltrating adenocarcinoma mixed with non-neoplastic ducts and lobules, with presence of well-established fibrous edge, and pushing margins (arrows) separating the fat (HE, 2×).</p>" ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">IDC: infiltrating ductal carcinoma; NA: non applicable.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Lesion \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Breast density \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ultrasound finding \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">MRI enhancement \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Size in the MRI (mm) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Anatomopathological diagnosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Histologic grade \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Stroma/cellularity ratio \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">c \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nodule \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mass \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IDC (luminal B) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">25 per cent \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nodule \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mass \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IDC (luminal B) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">55 per cent \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nodule \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mass \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IDC (luminal B) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">50 per cent \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">c \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nodule \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mass \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IDC (luminal B) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">50 per cent \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nodule \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mass \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IDC (luminal A) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">70 per cent \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">6<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nodule \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mass \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IDC (triple negative) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">50 per cent \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">7<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Segmental \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IDC (luminal B) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">55 per cent \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1594687.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Multicentric affectation with two (2) lesions in the same breast.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Characteristics of BI-RADS 6 lesions 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