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Update in Radiology
Update on meningioma: Clinical-radiological and radio-pathological correlation
Actualización sobre el meningioma: correlación clínico-radiológica y radio-patológica
A. Navarro-Ballestera,
Corresponding author
antonio.navarroball@gmail.com

Corresponding author.
, M. Aleixandre-Barrachinab, S.F. Marco-Doménecha
a Servicio de Radiodiagnóstico, Hospital General Universitario de Castellón, Castellón de la Plana, Castellón, Spain
b Servicio de Anatomía Patológica, Hospital General Universitario de Castellón, Castellón de la Plana, Castellón, Spain
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meaning blood vessel and &#8220;<span class="elsevierStyleItalic">-oma</span>&#8221;&#44; which translates as mass&#44; biological structure or tumour&#46; Although the first monographic scientific publication on these tumours is attributed to the French military surgeon Antoine Louis in the later years of the French Enlightenment &#40;18th century&#41;&#44; it was not until the Cavendish Conference in 1922 that Harvey Cushing gave birth to the term &#8220;meningioma&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The incidence of meningioma peaks at 22&#46;2 per 100&#44;000 population in the age range 75&#8211;89&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Diagnosis is three times more common in women than in men&#44; with this difference particularly pronounced in the 30&#8211;59 age range&#44; in tumour grade I and when located in the spine&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">There are many reasons&#44; beyond the high incidence&#44; to support the need for further studies on meningiomas&#46; Firstly&#44; the fact that they are mostly clinically silent makes it more difficult to obtain reliable data on epidemiology or clinical features&#46; Not surprisingly then&#44; some 80&#37; of these tumours are considered low-grade in the World Health Organisation &#40;WHO&#41; classification&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Secondly&#44; meningiomas have a high recurrence rate after surgery&#44; as well as a not-insignificant potential to be fatal&#44; both of which are related to histological grade&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The aim of this study was to analyse the most common locations for meningiomas and radiological behaviour based on their histological nature&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Syndromes associated with meningioma</span><p id="par0030" class="elsevierStylePara elsevierViewall">In people under the age of 40&#44; a finding of meningiomas raises the suspicion of neurofibromatosis type 2&#44; with intracranial meningiomas being an independent factor for poor prognosis associated with a two- to five-fold increase in the mortality rate for the neurofibromatosis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Other diseases which increase the risk of meningiomas are multiple endocrine neoplasia type 1&#44; Cowden syndrome&#44; Werner syndrome&#44; nevoid basal cell carcinoma syndrome&#44; Rubinstein-Taybi syndrome&#44; BAP1 tumour predisposition syndrome and familial meningiomatosis&#44; which is caused by germline mutations in SMARCB1 and SMARCE1 genes&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Symptoms of meningioma&#58; clinical-radiological correlation</span><p id="par0035" class="elsevierStylePara elsevierViewall">Most meningiomas are asymptomatic and detected incidentally&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> In those that do cause symptoms&#44; the specific dural&#44; intracranial or spinal location enables us to estimate the clinical presentation to expect&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Cerebral convexity&#58;</span> is the most common location&#46; Approximately one in four meningiomas occupy this position&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In symptomatic patients&#44; the most common neurological manifestations detected are headache &#40;43&#46;4&#37;&#41;&#44; motor disturbances &#40;34&#46;4&#37;&#41; and seizures &#40;32&#46;8&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Among the locations in convexity&#44; the most common is frontal &#40;53&#37;&#41;&#44; followed by parietal &#40;20&#37;&#41;&#44; temporal &#40;18&#37;&#41;&#44; occipital &#40;7&#37;&#41; and pterional &#40;2&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> It is important to be aware that meningiomas of the frontal convexity can cause psychological and neurocognitive disorders&#44; a less common presentation which may delay diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Skull base&#58;</span> according to some of the series with the largest number of cases analysed&#44; the location at the skull base as a whole &#40;anterior&#44; middle or posterior cranial fossa&#41; would be the most common of all&#44; even above that of convexity&#44; with a prevalence of 47&#37;&#8211;58&#46;5&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;12</span></a> Within the skull base&#44; the middle cranial fossa is the most common location&#44; followed by the anterior and posterior respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> When meningiomas in this location cause symptoms&#44; headache is the most common &#40;52&#46;1&#37;&#41;&#44; slightly more so than in convexity tumours&#46; In second place are visual disturbances &#40;46&#46;5&#37;&#41;&#44; typical of anterior fossa meningiomas&#46; Clinical manifestations related to alterations in the cerebellum are found in 31&#46;7&#37; of cases&#44; usually in posterior fossa tumours&#44; where hydrocephalus and cranial nerve-related abnormalities are also more common&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Hearing loss can occur&#44; in most cases after invasion of the internal auditory canal by cerebellopontine angle meningiomas<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Anosmia can also occur&#44; being about three times more common in skull base than in convexity meningiomas&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> We should particularly mention meningiomas located in the vicinity of the greater wing of the sphenoid bone&#44; which are divided into lateral&#44; medial and intermediate&#44; depending on their position&#46; Those located lateral to the greater wing of the sphenoid bone tend to cause epilepsy and&#47;or speech disturbances if located on the left-hand side&#46; Those medial to the greater wing can cause unilateral loss of vision&#59; if affecting the cavernous sinus&#44; they may be associated with other symptoms&#44; usually starting with oculomotor deficits &#40;paresis&#44; ophthalmoplegia&#44; ptosis&#44; diplopia and anisocoria&#41; and progressing to facial hypoaesthesia or hyperaesthesia due to trigeminal nerve involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Meningiomas of the middle cranial fossa&#44; in addition to the potential symptoms mentioned&#44; may also cause clinical manifestations due to cerebral ischaemia resulting from compression of the arteries that make up the circle of Willis&#44; and even alterations in pituitary function due to the mass effect of the tumour on the gland&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Parasagittal&#58;</span> defined as meningiomas which grow on at least one wall of the superior sagittal sinus&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Some 10&#37;&#8211;20&#37; of all meningiomas are found in this location&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;9</span></a> although differentiating between parasagittal meningiomas and those located in the high convexity is not always simple&#59; those considered to be convexity meningiomas can even have small points of attachment to the dura mater of the superior sagittal sinus &#40;SSS&#41;&#46; The clinical presentation of the two differs very little and will depend on their specific position&#46; However&#44; it should be remembered that parasagittal meningiomas sometimes invade the SSS&#44; and this significantly affects the neurosurgical strategy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Falx cerebri&#58;</span> about 8&#37; of meningiomas occupy this site<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;16</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; In this case&#44; the tumour arises from the falx cerebri&#44; but differs from the parasagittal tumour in that it is completely covered by the overlying cerebral cortex and does not affect the superior sagittal sinus&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> In the surgical series of Sung et al&#46;&#44; patients with falcine meningioma had symptoms such as headache &#40;30&#37;&#41;&#44; unilateral motor deficits &#40;16&#37;&#41;&#44; seizures &#40;7&#37;&#41; and personality disorders &#40;7&#37;&#41;&#44; with 6&#37; being asymptomatic&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> It has been found that&#44; at the same histological grade&#44; parasagittal and falcine meningiomas are more likely to recur&#44; possibly because of the greater difficulty in achieving complete resection in these locations&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Intraventricular&#58;</span> 0&#46;5&#37;&#8211;3&#37; of meningiomas<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; When located in the lateral ventricles&#44; it is more common for the left side to be affected&#59; this is also the case with other intracranial meningiomas&#44; but it is not understood why&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Unlike other types of meningioma&#44; it tends to be silent and cause mild&#44; long-lasting symptoms such as headache or visual disturbances&#46; This means the tumour volume is usually large at the time of diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Intraventricular meningioma is associated more often than other tumours with postoperative meningitis&#44; a potentially serious complication&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Optic nerve&#58;</span> like intraventricular and pineal region meningiomas&#44; those affecting the optic nerve are part of the intradural meningioma family&#46; They account for 2&#37; of all orbital tumours and 1&#37; of all meningiomas&#46; They are usually intraorbital and unilateral &#40;92&#37; and 95&#37; respectively&#41; and their most common form is secondary&#44; in other words caused by the extension of an intracranial meningioma into the orbit&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Spinal&#58;</span> account for about 1&#46;2&#37; of all meningiomas&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Most are located in the intradural compartment&#44; sparing the pial layer of the spinal cord&#44; and account for 25&#37;&#8211;45&#37; of all intradural spinal tumours&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> They are usually located in the thoracic spine &#40;78&#37;&#41;&#44; being less common in the cervical &#40;19&#37;&#41; and lumbar &#40;3&#37;&#41; areas&#46; In the axial plane&#44; they are most commonly lateral &#40;55&#37;&#41; or ventral &#40;29&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;24</span></a> They are more common in the older adult population and&#44; if diagnosed in young patients&#44; a genetic disorder such as neurofibromatosis type 2 or an aggressive histological subtype of the tumour should be suspected&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> The most common symptoms related to spinal meningioma are motor or sensory deficits &#40;84&#37;&#41;&#44; gait disturbances &#40;52&#37;&#8211;83&#37;&#41; and pain &#40;33&#37;&#8211;47&#37;&#41;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;24</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></li></ul></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Radiological features of meningioma</span><p id="par0360" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Plain X-ray&#58;</span> not a useful technique for the study of meningiomas&#46; In a very small number of cases&#44; intratumour calcifications&#44; the effect of meningiomas on the skullcap &#40;hyperostosis or bone resorption&#41; or enlargement of the meningeal artery grooves can be seen on skull X-rays&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a></p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">&#8226;</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Computed tomography</span><a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">o</span><p id="par0085" class="elsevierStylePara elsevierViewall">Calcification&#58; 25&#37;</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">o</span><p id="par0090" class="elsevierStylePara elsevierViewall">Perilesional oedema&#58; 60&#37;&#8211;67&#37; of meningiomas&#44; but more easily identifiable by MRI&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#44;29</span></a></p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">o</span><p id="par0095" class="elsevierStylePara elsevierViewall">Hyperostosis of adjacent bone&#58; 20&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">o</span><p id="par0100" class="elsevierStylePara elsevierViewall">Osteolysis of adjacent bone&#58; rare finding and seen in intraosseous or locally invasive meningiomas&#46;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">o</span><p id="par0105" class="elsevierStylePara elsevierViewall">Hyperdense relative to the rest of the brain in non-contrast study&#58; 60&#37;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">o</span><p id="par0110" class="elsevierStylePara elsevierViewall">Homogeneous and intense contrast enhancement&#58; 72&#37;&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">&#8226;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Magnetic resonance imaging &#40;MRI&#41;&#58; the technique of choice&#46;</p></li></ul></p><p id="par0120" class="elsevierStylePara elsevierViewall">It typically presents as an extra-axial mass with well-defined margins&#58;<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">&#8226;</span><p id="par0125" class="elsevierStylePara elsevierViewall">T1&#58; isointense with respect to the grey matter&#46;</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">&#8226;</span><p id="par0130" class="elsevierStylePara elsevierViewall">T2&#58; isointense or slightly hyperintense&#46;</p></li><li class="elsevierStyleListItem" id="lsti0095"><span class="elsevierStyleLabel">&#8226;</span><p id="par0135" class="elsevierStylePara elsevierViewall">Magnetic susceptibility sequences&#58; areas of signal loss coinciding with calcifications&#46;</p></li><li class="elsevierStyleListItem" id="lsti0100"><span class="elsevierStyleLabel">&#8226;</span><p id="par0140" class="elsevierStylePara elsevierViewall">T1 with gadolinium&#58; intense and homogeneous enhancement&#46; Occasionally&#44; there may be areas of calcification and&#47;or necrosis which do not enhance&#46;</p></li><li class="elsevierStyleListItem" id="lsti0105"><span class="elsevierStyleLabel">&#8226;</span><p id="par0145" class="elsevierStylePara elsevierViewall">Diffusion&#58; grade 2 or 3 tumours may have restricted diffusion &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41; but this is not a reliable predictor of histological grade&#44; due to its low negative predictive value&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0110"><span class="elsevierStyleLabel">&#8226;</span><p id="par0150" class="elsevierStylePara elsevierViewall">&#8220;<span class="elsevierStyleItalic">Dural tail sign</span>&#8221;&#58; defined as thickening and enhancement of the dura mater adjacent to the tumour on contrast studies and seen in up to 72&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> The presence of this sign may be useful for differentiating meningioma of the cerebellopontine angle from schwannoma&#44; for example&#44; as a dural tail is not usually associated with schwannoma&#46; However&#44; it is not a pathognomonic sign and can be identified in other types of cancer such as glial tumours&#44; lymphomas and even metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p></li><li class="elsevierStyleListItem" id="lsti0115"><span class="elsevierStyleLabel">&#8226;</span><p id="par0155" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Cerebrospinal fluid</span> &#8220;<span class="elsevierStyleItalic">cleft sign</span>&#8221;&#58; consists of a cleft of cerebrospinal fluid between the tumour and the underlying cortex and suggests the extra-axial origin of the lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This sign may not be found in grade 3 meningiomas&#44; due to their aggressive local behaviour&#46;</p></li><li class="elsevierStyleListItem" id="lsti0120"><span class="elsevierStyleLabel">&#8226;</span><p id="par0160" class="elsevierStylePara elsevierViewall">&#8220;<span class="elsevierStyleItalic">Tram-track sign</span>&#8221; <span class="elsevierStyleItalic">&#40;optic nerve meningioma&#41;</span>&#58; intense gadolinium enhancement of the optic nerve sheath surrounding the nerve&#44; producing an image resembling tram tracks&#46; It is important to remember that&#44; although this sign differentiates meningioma from glioma&#44; it can be found in other diseases &#40;for example&#44; orbital pseudotumour&#44; optic perineuritis&#44; orbital sarcoidosis&#44; lymphoma and metastasis&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0125"><span class="elsevierStyleLabel">&#8226;</span><p id="par0165" class="elsevierStylePara elsevierViewall">MRI spectroscopy&#58; in meningiomas&#44; it is common to find increased alanine&#44; choline and glutamine&#47;glutamate&#44; with reduced or absent N-acetylaspartate &#40;NAA&#41; and creatine&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Although elevated alanine has traditionally been considered characteristic of meningioma&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> it is not detected in all meningiomas and it may correlate inversely with the degree of tumour necrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> One publication suggests that an increased choline&#47;NAA ratio &#62;2&#46;409 may be indicative of a high tumour grade&#44; with a specificity of 86&#46;36&#37;&#44; although further studies are needed to validate the results&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> Increases in lactate or lipids have also been suggested in the past as indicators of high tumour grade&#59; unfortunately&#44; they have proven to not always be reliable parameters&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;34</span></a></p></li><li class="elsevierStyleListItem" id="lsti0130"><span class="elsevierStyleLabel">&#8226;</span><p id="par0170" class="elsevierStylePara elsevierViewall">Perfusion MRI&#58; meningiomas are hypervascular lesions and are therefore highly perfused in perfusion studies&#46; Relative cerebral blood volume &#40;rCBV&#41; will be increased&#44; with reported values of between 6 and 9<span class="elsevierStyleHsp" style=""></span>ml&#47;100<span class="elsevierStyleHsp" style=""></span>g&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> However&#44; a histological subtype such as angiomatous meningioma may have slightly higher figures&#44; due to its larger vascular component&#46; In contrast&#44; fibrous meningioma will show somewhat lower perfusion values due to the presence of hypovascular fibrous tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">35&#44;36</span></a></p></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Histological subtypes&#58; radiological-pathological correlation</span><p id="par0175" class="elsevierStylePara elsevierViewall">Meningioma has a separate category in the 2021 fifth edition of the World Health Organisation Classification of Tumours of the Central Nervous System&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> This classification system establishes 15 histological subtypes of meningioma&#44; emphasising that the criteria defining atypical or anaplastic meningioma &#40;current grades 2 and 3 respectively&#41; should be applied regardless of the underlying subtype&#46; However&#44; there are some subtypes which&#44; due to their high recurrence rates or aggressive behaviour&#44; are assigned a grade higher than 1&#46; It should be noted that some molecular biomarkers can also demonstrate the assigned classification and grade&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Histopathological criteria for differentiating grade 2 and 3 meningiomas<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a>&#58;<ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0135"><span class="elsevierStyleLabel">&#8226;</span><p id="par0185" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Grade 2 &#40;atypical&#41;&#58;</span> brain invasion&#44; between 4 and 19 mitoses in 10 consecutive high power fields &#40;HPF&#41; or the presence of three or more of the minor criteria &#40;increased cellularity&#44; small cells with a high nuclear&#47;cytoplasmic ratio&#44; prominent nucleoli&#44; foci of geographic or spontaneous necrosis and sheeting&#41; are the main diagnostic criteria for atypical meningiomas&#46; Chordoid and clear cell subtypes are directly categorised as atypical &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0140"><span class="elsevierStyleLabel">&#8226;</span><p id="par0190" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Grade 3 &#40;anaplastic&#41;&#58;</span> suggested by increased mitotic count of &#8805;20 in 10 consecutive HPF&#44; homozygous deletion of CDKN2A&#47;B&#44; areas of sarcoma-&#44; carcinoma- or melanoma-like appearance&#44; TERT promoter mutation &#40;<a class="elsevierStyleCrossRefs" href="#fig0015">Figs&#46; 3 and 6</a>&#41;&#46;<ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0145"><span class="elsevierStyleLabel">-</span><p id="par0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Angiomatous&#58;</span> 1&#46;5&#37;&#8211;2&#46;1&#37; of meningiomas&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">40&#44;41</span></a> As the name suggests&#44; they are tumours with abundant blood vessels &#40;more than 50&#37; of the total tumour volume&#41; combined with areas of classic meningothelial differentiation&#46; Characteristically&#44; they have a slightly higher rCBV on perfusion MRI than other subtypes&#46; Differentiation of this subtype from the microcystic subtype is particularly difficult&#44; as both have similar findings in relation to their apparent diffusion coefficient &#40;ADC&#41; and perfusion&#44; and it is not uncommon for the angiomatous subtype to show areas of cystic degeneration&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> A differential feature between the two subtypes could be peritumoural oedema &#40;seen in 100&#37; of pure angiomatous versus 66&#46;7&#37; of pure microcystic<span class="elsevierStyleSup">&#41;</span><a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> or the higher likelihood of a dural tail &#40;66&#46;7&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Despite being a histopathologically distinct entity&#44; it is not always easy to differentiate between angiomatous meningioma and solitary fibrous tumour of the meninges &#40;SFTM&#41;&#44; formerly known as haemangiopericytoma<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0035">Fig&#46; 7</a>&#41;&#46; Unlike the angiomatous subtype of meningioma&#44; SFTM are more common in males &#40;75&#37;&#41; and affect younger patients &#40;mean age 41&#46;4 compared to 48&#46;2 for meningioma&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> Radiologically&#44; the SFTM is isointense with respect to the grey matter in T1 and T2 and&#44; in general&#44; more often shows aggressive behaviour&#46; Also&#44; necrosis is more common&#44; with heterogeneous contrast uptake more likely than in meningioma&#46; In perfusion studies the rCBV of SFTM is even higher than that of angiomatous meningioma&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> On spectroscopy&#44; SFTM usually show a marked increase in choline with a lipid&#47;L-lactate peak&#44; increased glutamate&#47;glutamine&#44; increased myo-inositol&#44; decreased creatinine and no NAA&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> According to Ohba et al&#46;&#44; the combination of the criteria age &#60;45 years and myo-inositol &#62;6&#46;347 distinguishes SFTM from meningioma&#44; with a sensitivity of 100&#37; and a specificity of 97&#46;8&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p><elsevierMultimedia ident="fig0035"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0150"><span class="elsevierStyleLabel">-</span><p id="par0200" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Atypical&#58;</span> is a WHO grade 2 tumour&#44; alongside chordoid meningioma and clear cell meningioma&#46; This histological grade has shown an increased relative incidence in recent years&#44; accounting for 22&#46;7&#37;&#8211;24&#46;5&#37; of all cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">45&#44;46</span></a> It is foreseeably more aggressive&#44; fast-growing and prone to recurrence than grade 1&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> However&#44; radiologically it is indistinguishable from grade 1 or 3 meningiomas&#46;</p></li><li class="elsevierStyleListItem" id="lsti0155"><span class="elsevierStyleLabel">-</span><p id="par0205" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Anaplastic&#58;</span> 1&#37;&#8211;3&#37; of meningiomas&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> This is the most aggressive form of the tumour and is classified as WHO grade 3&#46; Studies suggest that a higher degree of cellularity and intratumour necrosis correlate statistically significantly with low ADC&#44;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">36&#44;47</span></a> and a significant correlation was also found between low ADC and high tumour cell proliferation rates in high-grade meningiomas&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a></p></li><li class="elsevierStyleListItem" id="lsti0160"><span class="elsevierStyleLabel">-</span><p id="par0210" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Chordoid&#58;</span> 1&#37;&#8211;4&#46;1&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> Classified as a WHO grade 2 tumour&#46; The most characteristic imaging features are hyperintensity on T2 &#40;probably due to its richness in mucoid matrix&#41;&#44; but above all&#44; hyperintensity on ADC&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> Cut-off values of ADC<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>1&#46;33<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;3</span><span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#47;s and normalised ADC &#40;NADC&#41; &#8805;1&#46;63 enable differentiation of chordoid meningioma from grade 1&#44; non-chordoid or focal chordoid grade 2 meningiomas &#40;&#60;50&#37;&#41; and grade 3 meningiomas on preoperative imaging with considerable diagnostic accuracy&#44; as all of the above usually show a more pronounced diffusion restriction with a low ADC &#40;800<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;6</span><span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#47;s&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a></p></li><li class="elsevierStyleListItem" id="lsti0165"><span class="elsevierStyleLabel">-</span><p id="par0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Clear cells&#58;</span> 0&#46;2&#37;&#8211;1&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">53&#44;54</span></a> Usually located in the cerebellopontine angle and in the spine&#44; especially in the cauda equina&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> They are classified as grade 2 and on imaging have the typical meningioma appearance&#44; with no differentiating features &#40;<a class="elsevierStyleCrossRefs" href="#fig0020">Figs&#46; 4 and 5</a>&#41;&#46; However&#44; they appear to show a very distinctive epigenetic signature&#44; with frequent mutations in the SMARCE1 gene and&#47;or loss of expression of the SMARCE protein&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a></p></li><li class="elsevierStyleListItem" id="lsti0170"><span class="elsevierStyleLabel">-</span><p id="par0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Fibrous or fibroblastic&#58;</span> considered one of the most common subtypes&#44; accounting for 7&#46;1&#37;&#8211;10&#46;2&#37; of the total in its isolated form&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43&#44;56</span></a> As it is more common in its combined form &#40;transitional meningioma&#41;&#44; it is often not possible to differentiate it from the meningothelial subtype&#46; However&#44; in pure fibrous meningiomas&#44; a loss of signal on T2 can be identified due to their high collagen content&#44; a finding that distinguishes them from other subtypes of meningioma&#44; opening up the differential diagnosis towards other types of disease such as solitary fibrous tumour of the dura or histiocytosis &#40;Erdheim-Chester disease&#41;&#46; Another way to differentiate this subtype of meningioma is by detecting a mutation in the NF2 tumour suppressor gene&#44; which occurs in most neurofibromatosis type 2 and in 40&#37;&#8211;60&#37; of sporadic meningiomas&#44; especially in the fibrous and transitional subtypes and when located in the convexity and posterior fossa &#40;skull base&#41;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0040">Fig&#46; 8</a>&#41;&#46;</p><elsevierMultimedia ident="fig0040"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0175"><span class="elsevierStyleLabel">-</span><p id="par0225" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Lymphoplasmacytic&#58;</span> 0&#46;5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> The longest review to date is of 164 cases&#44; in which the authors note that this meningioma does not have a characteristic radiological appearance and cannot be differentiated from other subtypes&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a></p></li><li class="elsevierStyleListItem" id="lsti0180"><span class="elsevierStyleLabel">-</span><p id="par0230" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Meningothelial&#58;</span> the most common subtype &#40;17&#37;&#41;&#44; second only to transitional meningioma&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> Usually shows the general radiological characteristics of meningioma &#40;see section &#8220;Radiological features of meningioma&#8221;&#41;&#44; with no distinct imaging features to differentiate it from other subtypes&#46;</p></li><li class="elsevierStyleListItem" id="lsti0185"><span class="elsevierStyleLabel">-</span><p id="par0235" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Metaplastic&#58;</span> 0&#46;04&#37;&#8722;0&#46;21&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> In this case&#44; the tumour cells of the meningioma &#40;usually of the meningothelial&#44; fibrous or transitional subtypes&#41; differentiate to adopt the tissue characteristics of other parts of the body&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> Therefore&#44; the radiological appearance will depend on the type of tissue being expressed&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0190"><span class="elsevierStyleLabel">&#8226;</span><p id="par0240" class="elsevierStylePara elsevierViewall">Cartilaginous&#58; no more than 10 cases have been reported in the scientific literature&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> As the name suggests&#44; the meningioma takes on a cartilaginous appearance&#46; It may be difficult to distinguish from chondroblastoma or chondrosarcoma&#44; especially when located in the spine&#46;</p></li><li class="elsevierStyleListItem" id="lsti0195"><span class="elsevierStyleLabel">&#8226;</span><p id="par0245" class="elsevierStylePara elsevierViewall">Lipomatous&#58; the meningothelial cells take on an appearance resembling adipocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0045">Fig&#46; 9</a>&#41;&#46; Some studies have suggested that the accumulation of lipids in these cells is due to altered metabolism rather than true metaplasia&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> If there is a sufficient amount of fatty tissue&#44; they will be hypointense on CT and hyperintense on MRI on T1-weighted sequences&#44; with loss of signal after fat suppression&#46;</p><elsevierMultimedia ident="fig0045"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0200"><span class="elsevierStyleLabel">&#8226;</span><p id="par0250" class="elsevierStylePara elsevierViewall">Melanotic&#58; if there is a sufficient amount of melanin&#44; it will be hyperintense on T1&#44; with variable behaviour in T2 &#40;the presence of haemorrhage can cause hypointensity&#41; and homogeneous contrast uptake&#46; This differs from melanomas and meningeal melanocytosis in that they tend to have a more heterogeneous uptake pattern&#46; However&#44; it is not uncommon for them to be confused on imaging&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a></p></li><li class="elsevierStyleListItem" id="lsti0205"><span class="elsevierStyleLabel">&#8226;</span><p id="par0255" class="elsevierStylePara elsevierViewall">Myxoid&#58; myxoid transformation involves the presence of endothelial cells&#44; pericytes and stromal cells&#46; This type has the general appearance of any meningioma&#44; with no distinctive imaging features&#46; Immunohistochemistry plays an important role in differentiating myxoid from other meningiomas which also have a stromal matrix&#44; such as chordoid meningioma&#46;</p></li><li class="elsevierStyleListItem" id="lsti0210"><span class="elsevierStyleLabel">&#8226;</span><p id="par0260" class="elsevierStylePara elsevierViewall">Bone&#58; similar characteristics to other meningiomas&#46; Their bone differentiation makes it virtually impossible to differentiate them from meningiomas with a tendency to calcify &#40;psammomatous&#41; and intraosseous meningiomas&#46;</p></li><li class="elsevierStyleListItem" id="lsti0215"><span class="elsevierStyleLabel">&#8226;</span><p id="par0265" class="elsevierStylePara elsevierViewall">Xanthomatous&#58; imaging characteristics are very similar to the lipomatous variant of meningioma&#44; and can only be differentiated on histological examination&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a><ul class="elsevierStyleList" id="lis0035"><li class="elsevierStyleListItem" id="lsti0220"><span class="elsevierStyleLabel">-</span><p id="par0270" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Microcystic&#58;</span> 1&#37;&#8211;1&#46;6&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a> Radiological features suggestive of this subtype include hypointensity on T1-weighted images and irregular peripheral gadolinium uptake&#46; However&#44; although this uptake pattern is very specific &#40;94&#37;&#41;&#44; it is not very sensitive &#40;27&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a> Another typical feature is that&#44; compared to other subtypes of the same grade&#44; it tends to have a larger volume of peritumoural oedema&#44; which seems to be due to a higher vascular permeability factor&#47;vascular endothelial growth factor ratio<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>B&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0225"><span class="elsevierStyleLabel">-</span><p id="par0275" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Papillary&#58;</span> 1&#37;&#8211;2&#46;5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> Papillary meningiomas are characterised by their aggressive behaviour&#44; with a greater tendency towards recurrence and even metastasis&#44;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a> but they are no longer classified as grade 3&#44; as in the previous WHO classification&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a></p></li><li class="elsevierStyleListItem" id="lsti0230"><span class="elsevierStyleLabel">-</span><p id="par0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Psammomatous&#58;</span> 0&#46;5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> We have to differentiate between the terms &#8220;<span class="elsevierStyleItalic">calcification</span>&#8221; and &#8220;<span class="elsevierStyleItalic">ossification</span>&#8221;&#46; &#8220;<span class="elsevierStyleItalic">Calcification</span>&#8221; is a radiological concept which usually refers to the accumulation of psammoma bodies and is therefore common in psammomatous meningioma&#46; Ossification in meningioma manifests as the presence of mature or immature bone tissue within the tumour and is a much rarer phenomenon histologically&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">68</span></a> On CT it appears as a calcified lesion&#44; although when the psammoma bodies are more dispersed&#44; it shows as a hyperdense mass without clear calcifications&#46; On MRI&#44; it may show hypointensity on T2-weighted images and loss of signal on magnetic susceptibility sequences &#40;<a class="elsevierStyleCrossRef" href="#fig0050">Fig&#46; 10</a>&#41;&#46;</p><elsevierMultimedia ident="fig0050"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0235"><span class="elsevierStyleLabel">-</span><p id="par0285" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Rabdoid&#58;</span> 0&#46;004&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a> The term rhabdoid refers to the characteristic resemblance of the cells to a rhabdomyoblast without true musculoskeletal differentiation&#46; This histological type usually means a poor prognosis and a tendency for recurrence&#46; They can have a cystic component &#40;38&#37;&#41; and marked peritumoural oedema&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a> There may be associated bone changes&#44; ranging from hyperostosis &#40;60&#37;&#41; to bone destruction &#40;33&#46;33&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a></p></li><li class="elsevierStyleListItem" id="lsti0240"><span class="elsevierStyleLabel">-</span><p id="par0290" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Secretory&#58;</span> 0&#46;5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> They tend to be located at the base of the skull&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a> Radiological features are indistinguishable from other meningiomas&#44; although they are more likely to show hyperintensity on T2-weighted images &#40;95&#46;6&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a></p></li><li class="elsevierStyleListItem" id="lsti0245"><span class="elsevierStyleLabel">-</span><p id="par0295" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Transitional&#58;</span> the most common subtype &#40;39&#46;8&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> Combined form of meningothelial and fibroblastic meningioma&#59; imaging features will depend on which component is predominant&#46;</p></li></ul></p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="par0300" class="elsevierStylePara elsevierViewall">Imaging techniques and particularly MRI can be a useful tool to guide the diagnosis of meningioma&#44; ruling out alternative diagnoses with different management&#44; and sometimes helping us make a preliminary estimation of the potential histological subtype and grade&#46; Findings such as the presence of a cerebrospinal fluid cleft around the lesion may demonstrate its extra-axial nature&#44; while low ADC values may point to a high tumour grade&#44; to cite a few examples&#46; However&#44; based on current scientific evidence&#44; it is not yet possible to establish a sufficiently consistent radiological-pathological correlation&#44; so the radiologist has to delegate the definitive diagnosis of the disease to the pathologist&#46; Future development of imaging techniques based on genomics and proteomics could be the key to a more accurate correlation between imaging and histological subtype&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Funding</span><p id="par0305" class="elsevierStylePara elsevierViewall">This study received no specific grants from public agencies&#44; the commercial sector or non-profit organisations&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Authorship</span><p id="par0365" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0040"><li class="elsevierStyleListItem" id="lsti0250"><span class="elsevierStyleLabel">1</span><p id="par0310" class="elsevierStylePara elsevierViewall">Responsible for the integrity of the study&#58; ANB&#44; MAB and SMD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0255"><span class="elsevierStyleLabel">2</span><p id="par0315" class="elsevierStylePara elsevierViewall">Study conception&#58; ANB&#44; MAB and SMD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0260"><span class="elsevierStyleLabel">3</span><p id="par0320" class="elsevierStylePara elsevierViewall">Study design&#58; ANB&#44; MAB and SMD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0265"><span class="elsevierStyleLabel">4</span><p id="par0325" class="elsevierStylePara elsevierViewall">Data collection&#58; ANB&#44; MAB and SMD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0270"><span class="elsevierStyleLabel">5</span><p id="par0330" class="elsevierStylePara elsevierViewall">Data analysis and interpretation&#58; ANB&#44; MAB and SMD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0275"><span class="elsevierStyleLabel">6</span><p id="par0335" class="elsevierStylePara elsevierViewall">Literature search&#58; ANB&#44; MAB and SMD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0280"><span class="elsevierStyleLabel">7</span><p id="par0340" class="elsevierStylePara elsevierViewall">Drafting of the article&#58; ANB&#44; MAB and SMD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0285"><span class="elsevierStyleLabel">8</span><p id="par0345" class="elsevierStylePara elsevierViewall">Critical review of the manuscript with intellectually relevant contributions&#58; ANB&#44; MAB and SMD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0290"><span class="elsevierStyleLabel">9</span><p id="par0350" class="elsevierStylePara elsevierViewall">Approval of the final version&#58; ANB&#44; MAB and SMD&#46;</p></li></ul></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of interest</span><p id="par0355" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Meningiomas are tumors that originate in the arachnoid villi and are the most common non-glial neoplasm in the central nervous system&#46; The clinical manifestations associated with meningioma depend&#44; fundamentally&#44; on its location&#46; The location in the cerebral convexity is the most frequent&#44; especially in the frontal lobes&#44; manifesting with headache&#44; motor disturbances&#44; seizures and even neurocognitive disorders&#46; There are 15 histologic subtypes of meningioma and three histologic grades&#46; Within these&#44; grades two and three have a worse prognosis and a higher rate of recurrence&#44; as well as a radiological behavior that is generally more aggressive&#46; Although there are some imaging features that can suggest a specific subtype&#44; the definitive diagnosis will always require histological&#47;molecular confirmation&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Los meningiomas son tumores que se originan en las vellosidades aracnoideas y que constituyen la neoplasia no glial m&#225;s com&#250;n en el sistema nervioso central&#46; Las manifestaciones cl&#237;nicas asociadas al meningioma dependen&#44; fundamentalmente&#44; de su localizaci&#243;n&#46; La ubicaci&#243;n en la convexidad cerebral es las m&#225;s frecuente&#44; especialmente en l&#243;bulos frontales&#44; manifest&#225;ndose con cefalea&#44; alteraciones motoras&#44; convulsiones e&#44; incluso&#44; con trastornos neurocognitivos&#46; Existen 15 subtipos histol&#243;gicos de meningioma y tres grados histol&#243;gicos&#46; Dentro de estos&#44; los grados dos y tres tienen un peor pron&#243;stico y una mayor tasa de recurrencia&#44; as&#237; como un comportamiento radiol&#243;gico&#44; por lo general&#44; m&#225;s agresivo&#46; Aunque existen algunas caracter&#237;sticas de imagen que pueden permitir sugerir un subtipo concreto&#44; el diagn&#243;stico definitivo siempre requerir&#225; la confirmaci&#243;n histol&#243;gica&#47;molecular&#46;</p></span>"
      ]
    ]
    "multimedia" => array:10 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
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        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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        "detalles" => array:1 [
          0 => array:3 [
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Incidental finding in a 63-year-old woman who had MRI for migraine headache&#58; a&#41; Sagittal T2-weighted MRI&#46; Note the lesion in the cerebellopontine angle &#40;arrow&#41;&#46; T2 hypointensity may be evidence of the meningioma histological subtype&#46; The presence of a hyperintense halo on T2 along its border &#40;cleft sign&#41; indicates the extra-axial location of the lesion &#40;arrowhead&#41;&#59; b&#41; T1-weighted fat-saturated gadolinium-enhanced sequence showing the lesion with heterogeneous uptake &#40;arrow&#41;&#59; c&#41; Microscopic image at 200x magnification with haematoxylin-eosin staining&#44; showing a proliferation of spindle-shaped meningothelial cells with predominantly hyaline stromal cells forming interlacing bundles&#46; Pathology diagnosis of grade 1 fibrous meningioma&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
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        "detalles" => array:1 [
          0 => array:3 [
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">72-year-old female patient&#44; being investigated by her neurologist for vertigo&#58; a&#41; Sagittal FLAIR MRI showing a meningioma of the frontal falx cerebri&#44; isointense with respect to the grey matter and no discernible oedema in the adjacent brain parenchyma&#59; b&#41; Sagittal T1-weighted fat-saturated gadolinium-enhanced MRI&#46; Homogeneous contrast uptake can be seen&#59; c&#41; Macroscopic appearance of the tumour after resection&#44; showing a multilobulated nodular formation with a smooth external surface and whitish colouring&#59; d&#41; Microscopic image of the lesion at 100x magnification and haematoxylin-eosin staining&#44; showing spindle cells arranged in parallel fascicles with collagenised stroma&#46; Pathology diagnosis of grade 1 fibrous meningioma&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 2600
            "Ancho" => 636
            "Tamanyo" => 338910
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        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0360"
            "detalle" => "Figure "
            "rol" => "short"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">71-year-old female patient with progressive neurological deterioration in the previous two months&#44; with bradypsychia&#44; motor incoordination and motor disorientation&#58; a&#41; Axial T2-weighted MRI&#46; Lesion inside the left ventricle&#44; hypointense and multi-lobulated&#59; b&#41; Axial T1-weighted fat-saturated gadolinium-enhanced MRI of the same patient&#46; Shows contrast uptake&#44; with areas of central necrosis&#59; &#40;c&#41; Microscope image at 200x magnification&#44; with haematoxylin-eosin staining&#46; Neoplastic cellularity is evident with moderate nuclear pleomorphism and foci of necrosis&#59; d&#41; Microscope image at 400x magnification and haematoxylin-eosin staining&#46; Mitotic figures &#40;circles&#41; can be seen in a lesion with a high proliferative index&#46; Pathology diagnosis of grade 3 anaplastic meningioma&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 2505
            "Ancho" => 586
            "Tamanyo" => 318619
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0365"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">34-year-old female patient with a month-long history of paraesthesia in hands and feet&#58; a&#41; Axial T2-weighted MRI&#46; Heterogeneous predominantly hyperintense mass &#40;arrow&#41;&#44; displacing the medulla towards the posterior and left lateral region &#40;arrowhead&#41;&#44; causing slightly abnormal signal intensity&#44; related to compressive myelopathy&#59; b&#41; fat-suppressed T2-weighted sagittal MRI showing the same lesion &#40;arrow&#41;&#59; c&#41; and d&#41; Microscopic images at 100&#215; and 200&#215; magnification respectively&#44; with haematoxylin-eosin staining&#44; showing a proliferation of clusters and sheets of clear cells delimited by hyalinised collagen septa&#46; Higher magnification &#40;&#215;200&#41; shows clusters of polygonal meningothelial cells with clear granular cytoplasm&#46; Pathology diagnosis of clear cell meningioma with areas of grade 2 chordoid meningioma&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 2078
            "Ancho" => 2007
            "Tamanyo" => 674785
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0370"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">a&#41; 65-year-old male patient with behavioural disturbance and temporospatial disorientation&#46; T2-weighted axial MRI&#46; Note the large number of cystic areas inside the lesion and the large amount of adjacent vasogenic oedema&#46; On the right of the image is a 400&#215; magnification microscope image with haematoxylin-eosin staining&#44; showing a sheet-like proliferation of polygonal cells with homogeneous nuclei and large&#44; clear cytoplasm&#46; Pathology diagnosis of grade 2 clear cell meningioma&#59; b&#41; 64 year old woman who went to her doctor with a more than 10-year history of a left frontal tumour&#46; She had no neurological symptoms&#46; Axial T2-weighted MRI shows an extra-axial mass in the left frontal convexity&#44; predominantly hyperintense on T2&#44; associated with hyperostosis of the adjacent skullcap and an increase in soft tissue on the scalp&#46; On the right of the image is the appearance of the lesion under 200&#215; magnification microscopy with haematoxylin-eosin staining&#44; showing meningothelial cell proliferation with intranuclear inclusions &#40;circle&#41; associated with micro &#40;&#42;&#41; and macro &#40;&#35;&#41; cysts&#46; They are true cysts without epithelial lining as a result of degenerative change&#46; As can be seen in this figure&#44; several subtypes of meningioma can show a macroscopic cystic component&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr6.jpeg"
            "Alto" => 1334
            "Ancho" => 2007
            "Tamanyo" => 626545
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0375"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">a&#41; 63 year old woman with an episode of partial seizures&#46; Axial ADC map in MRI&#46; Extra-axial mass in the right frontal convexity &#40;arrow&#41;&#44; with invasion and destruction of the adjacent skullcap&#46; Note the clear hypointensity in ADC suggesting high histological grade&#46; On the right is the macroscopic specimen of the surgical resection&#44; consisting of a multi-lobulated nodular formation with a smooth external surface and a brownish colour&#46; Light microscopy at 200x magnification and haematoxylin-eosin staining shows a hypercellular lesion with increased nuclear variability&#46; The definitive diagnosis was grade 3 anaplastic meningioma&#59; b&#41; Incidental finding in a 59-year-old woman having MRI for mild cognitive impairment&#46; Axial ADC map&#46; Left parasagittal extra-axial mass&#44; isointense with respect to the grey matter&#44; suggesting low histological grade&#46; On the right is a light microscope image of the same lesion at 100x magnification with haematoxylin-eosin staining&#44; showing a mesenchymal-like neoplasm with a storiform growth pattern&#59; at higher magnification the lesion consists of spindle-shaped meningothelial cells without atypia&#44; with collagenised stromal areas&#46; The final histological diagnosis was grade 1 fibrous meningioma&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "fig0035"
        "etiqueta" => "Figure 7"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr7.jpeg"
            "Alto" => 1976
            "Ancho" => 2007
            "Tamanyo" => 566489
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0380"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">a&#41; 65-year-old male who attended the emergency department due to epileptic seizures&#46; Axial T2-weighted MRI showing an extra-axial mass in the left frontal convexity &#40;arrow&#41;&#44; with cystic areas inside and marked oedema&#46; On the right is a specimen of the tumour &#40;haematoxylin-eosin stain&#44; &#215;100 magnification under the microscope&#41; with a proliferation of meningothelial cells associated with calcifications and vascular proliferation with vessels of different calibre&#44; all suggestive of the haemangiomatous subtype of grade 1 meningioma&#59; &#40;b&#41; 47-year-old woman having a brain CT scan for migraine-type headache&#46; Axial T2 MRI showing a bilobulated extra-axial mass in the right frontal convexity &#40;black arrow&#41;&#44; cystic areas inside&#44; moderate oedema and mass effect&#44; with displacement of the interhemispheric fissure to the left&#46; On the right is a 100&#215; magnification microscopy image showing diffuse nuclear staining and STAT6 characteristic of haemangiopericytoma&#46; Although their radiological appearance can be confused&#44; as a general rule&#44; angiomatous meningioma and haemangiopericytoma can be differentiated on pathology examination&#46;</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "fig0040"
        "etiqueta" => "Figure 8"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr8.jpeg"
            "Alto" => 2639
            "Ancho" => 2007
            "Tamanyo" => 614032
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0385"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">62-year-old female patient with a history of neurofibromatosis type 2&#44; with left-dominant homonymous haemianopia&#58; a&#41; Non-contrast CT scan&#46; Multiple calcified extra-axial lesions identified &#40;arrow&#41;&#44; compatible with meningioma&#59; b&#41; Fat-saturated T1-weighted MRI with gadolinium injection&#46; Homogeneous contrast uptake is observed in most lesions &#40;arrow&#41;&#59; c&#41; Microscopy image at 100x magnification with haematoxylin-eosin staining showing a fasciculated spindle cell neoplasm with cellular predominance&#59; d&#41; Progesterone receptor immunohistochemistry at 100x magnification&#59; diffuse nuclear staining&#46; Pathology diagnosis was grade 1 fibrous meningioma&#46;</p>"
        ]
      ]
      8 => array:8 [
        "identificador" => "fig0045"
        "etiqueta" => "Figure 9"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr9.jpeg"
            "Alto" => 2408
            "Ancho" => 874
            "Tamanyo" => 314448
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0390"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">74-year-old female patient with 5&#8211;10<span class="elsevierStyleHsp" style=""></span>min episode of loss of consciousness&#46; Following this&#44; she had self-limiting left facial paresis and dysarthria&#58; a&#41; CT with intravenous contrast showing an extra-axial mass in the temporal convexity &#40;arrow&#41;&#46; There is a central region with fat density which corresponds to an area of fat metaplasia&#46; The rest of the lesion showed intense&#44; homogeneous uptake of contrast&#59; b&#41; Sagittal T1-weighted MRI sequence&#46; The fatty component seen on CT shows clear hyperintensity &#40;arrow&#41;&#59; &#40;c&#41; Image obtained with 100x magnification microscopy with haematoxylin-eosin staining&#46; Some meningothelial cells can be seen containing fat-filled vacuoles which make them resemble adipocytes&#59; the diagnosis is grade 1 metaplastic lipomatous meningioma&#46;</p>"
        ]
      ]
      9 => array:8 [
        "identificador" => "fig0050"
        "etiqueta" => "Figure 10"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr10.jpeg"
            "Alto" => 2266
            "Ancho" => 2007
            "Tamanyo" => 718986
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0395"
            "detalle" => "Figure 1"
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">62-year-old female patient with worsening paraparesis&#44; increased spasticity and abolished reflexes&#58; &#40;a&#41; Axial T2-weighted MRI of the spine&#46; Intradural extramedullary lesion &#40;arrow&#41; causing hydrosyringomyelia &#40;arrowhead&#41;&#59; &#40;b&#41; T1-weighted MRI with gadolinium&#46; There is homogeneous contrast uptake&#44; with lesion enclosing nerve roots &#40;arrow&#41;&#59; &#40;c&#41; 40&#215; magnification microscopy image with haematoxylin-eosin staining showing cell proliferation interspersed with abundant psammoma bodies&#59; &#40;d&#41; Higher magnification image &#40;&#215;100&#41; of psammoma bodies&#46; Pathology diagnosis of grade 1 psammomatous meningioma&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
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                        "tituloSerie" => "Neurochirurgie&#46;"
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                        "paginaFinal" => "79"
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es en pt

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