metricas
covid
Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) One-day protocol for 18F-FDG and 13N-ammonia PET/CT with uptake decoupling score...
Journal Information
Vol. 39. Issue 2.
Pages 68-74 (March - April 2020)
Share
Share
Download PDF
More article options
Visits
27
Vol. 39. Issue 2.
Pages 68-74 (March - April 2020)
Original Article
One-day protocol for 18F-FDG and 13N-ammonia PET/CT with uptake decoupling score in differentiating untreated low-grade glioma from inflammation
Protocolo de un día para la TEP/TC con amoníaco 18F-FDG y 13N con puntuación de desacoplamiento de la captación para diferenciar el glioma de bajo grado no tratado de la inflamación
Visits
27
Y. Changa,1, Y. Donglanb,1, S. Xinchonga, L. Ganhuaa, Z. Binga, L. Yaoc, Z. Rutongc, H. Qiaoa, Z. Xiangsonga,
Corresponding author
xiaolong-4310@163.com

Corresponding author at: Department of Nuclear Medicine, the First Affiliated Hospital of Sun Yat-Sen University. Zhongshan Er Road 58#, Guangzhou, China.
a Department of Nuclear Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
b Department of Medical Engineering, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
c School of Data and Computer Science, Sun Yat-Sen University, Guangzhou, China
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Tables (2)
Table 1. Patient characteristics.
Table 2. PET results of T/N ratios and decoupling score for 13N-ammonia and 18F-FDG PET.
Show moreShow less
Abstract
Purpose

Accurate identification of low-grade gliomas (LGGs; World Health Organization grades I and II) and their differentiation from brain inflammation lesions (BILs) remains difficult; however, it is essential for treatment. This study assessed whether a one-day protocol for voxel-wise 18F-FDG and 13N-ammonia PET/CT with uptake decoupling analysis could differentiate LGGs from BILs.

Materials and methods

Twenty-eight patients with LGGs and 16 patients with BILs underwent 18F-FDG and 13N-ammonia PET/CT on the same day before any type of therapy. The decoupling score and tumor-to-normal tissue (T/N) ratio of 18F-FDG and 13N-ammonia were calculated at each location. Student’s t-test was used to compare values, and ROC curve analysis was used to establish a cut-off value for the T/N ratio and decoupling score. Area under the curve (AUC) was calculated to evaluate differential efficacy.

Results

Significant differences were observed in 13N-ammonia T/N ratio (p = 0.018) and decoupling score (p = 0.003) between LGGs and BILs; however, the 18F-FDG T/N ratio did not show any differences (p = 0.413). Optimal cut-off values for 18F-FDG T/N ratio, 13N-ammonia T/N ratio, and decoupling score were 0.73, 0.97, and 2.31, respectively, with corresponding AUCs of 0.48, 0.68, and 0.77. The respective sensitivity, specificity, and accuracy parameters using these cut-off values were 53.6%, 62.5%, and 56.8%, respectively, for 18F-FDG; 50.0%, 75.0%, and 59.1%, respectively, for 13N-ammonia; and 60.7%, 93.8%, and 72.7%, respectively, for decoupling score.

Conclusions

18F-FDG/13N-ammonia uptake decoupling score can be used to discriminate between LGGs and BILs. Use of a decoupling map of these two tracers can improve visual analysis and diagnostic accuracy.

Keywords:
One-Day protocol
13N-ammonia
18F-FDG
Voxel-Wise analysis
Low-Grade gliomas
Resumen
Propósito

La identificación precisa de los gliomas de bajo grado (LGGs; grados I y II de la Organización Mundial de la Salud) y su diferenciación de las lesiones por inflamación cerebral (BILs) sigue siendo difícil; sin embargo, es esencial para el tratamiento. Este estudio evaluó si un protocolo de un día para la TEP/TC con amoníaco 18F-FDG y 13Namoníaco con análisis de desacoplamiento de la captación podría diferenciar los LGG de los BIL.

Materiales y métodos

Veintiocho pacientes con GLG y 16 pacientes con BIL se sometieron a TEP/TC con 18F-FDG y 13N-amoníaco el mismo día antes de cualquier tipo de terapia. La puntuación de desacoplamiento y la relación tumor/tejido normal (T/N) de 18F-FDG y 13N-amoníaco se calcularon en cada localización. Se utilizó la prueba t de Student para comparar valores, y el análisis de la curva ROC para establecer un valor de corte para la relación T/N y la puntuación de desacoplamiento. Se calculó la CUA para evaluar la eficacia diferencial.

Resultados

Se observaron diferencias significativas en la relación T/N de 13N-amoníaco (p=0,018) y en la puntuación de desacoplamiento (p=0,003) entre los LGG y los BIL; sin embargo, la relación T/N de 18F-FDG no mostró ninguna diferencia (p=0,413). Los valores de corte óptimos para la relación T/N de 18F-FDG, la relación T/N de 13N-amoníaco y la puntuación de desacoplamiento fueron 0,73, 0,97 y 2,31, respectivamente, con AUC correspondientes de 0,48, 0,68 y 0,77. Los respectivos parámetros de sensibilidad, especificidad y precisión que utilizan estos valores de corte fueron 53,6%, 62,5% y 56,8%, respectivamente, para 18F-FDG; 50,0%, 75,0% y 59,1%, respectivamente, para la amoníaco 13N; y 60,7%, 93,8% y 72,7%, respectivamente, para la puntuación de desacoplamiento.

Conclusiones

La puntuación de desacoplamiento de la captación de amoníaco 18FFDG/ 13N se puede utilizar para discriminar entre LGG y BIL. El uso de un mapa de desacoplamiento de estos dos trazadores puede mejorar el análisis visual y la precisión del diagnóstico.

Palabras clave:
protocolo de un día
13N-amonio
18F-FDG
análisis de voxel
gliomas de bajo grado

Article

These are the options to access the full texts of the publication Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos