array:23 [ "pii" => "S1699885520301100" "issn" => "16998855" "doi" => "10.1016/j.patol.2020.09.005" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "647" "copyright" => "Sociedad Española de Anatomía Patológica" "copyrightAnyo" => "2020" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2021;54:242-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S1699885521000489" "issn" => "16998855" "doi" => "10.1016/j.patol.2021.05.003" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "674" "copyright" => "Sociedad Española de Anatomía Patológica" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Rev Esp Patol. 2021;54:250-62" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">REVISIÓN</span>" "titulo" => "Consenso multidisciplinar para optimizar la determinación de alteraciones del gen <span class="elsevierStyleItalic">NTRK</span>" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "250" "paginaFinal" => "262" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Multidisciplinary consensus on optimizing the detection of <span class="elsevierStyleItalic">NTRK</span> gene alterations in tumours" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 572 "Ancho" => 755 "Tamanyo" => 109329 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El apéndice sirve tanto de control positivo como negativo para la IHQ de <span class="elsevierStyleItalic">NTRK</span>. La positividad de las estructuras neurales de la pared del apéndice nos asegura el correcto funcionamiento de la fase analítica de la IHQ (clon EPR17341, ventana, x400).</p> <p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">IHQ: inmunohistoquímica; NTRK: <span class="elsevierStyleItalic">neurotrophic receptor tyrosine kinase.</span></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Federico Rojo, Ramón Colomer, Fernando López-Ríos, Francisco Bautista, Rosa Álvarez, Enrique de Álava, Raquel Hladun, Pilar Garrido" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Federico" "apellidos" => "Rojo" ] 1 => array:2 [ "nombre" => "Ramón" "apellidos" => "Colomer" ] 2 => array:2 [ "nombre" => "Fernando" "apellidos" => "López-Ríos" ] 3 => array:2 [ "nombre" => "Francisco" "apellidos" => "Bautista" ] 4 => array:2 [ "nombre" => "Rosa" "apellidos" => "Álvarez" ] 5 => array:2 [ "nombre" => "Enrique" "apellidos" => "de Álava" ] 6 => array:2 [ "nombre" => "Raquel" "apellidos" => "Hladun" ] 7 => array:2 [ "nombre" => "Pilar" "apellidos" => "Garrido" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885521000489?idApp=UINPBA00004N" "url" => "/16998855/0000005400000004/v1_202109180718/S1699885521000489/v1_202109180718/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1699885521000040" "issn" => "16998855" "doi" => "10.1016/j.patol.2021.01.003" "estado" => "S300" "fechaPublicacion" => "2021-10-01" "aid" => "654" "copyright" => "Sociedad Española de Anatomía Patológica" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2021;54:234-41" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>" "titulo" => "Microscopía electrónica en biopsias renales: una evaluación de su utilidad en el siglo XXI" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "234" "paginaFinal" => "241" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The relevance of electron microscopy in kidney biopsies to 21<span class="elsevierStyleSup">st</span> century pathology" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1947 "Ancho" => 2508 "Tamanyo" => 1823318 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">En alteraciones hereditarias fue más necesaria la microscopía electrónica para llegar a un diagnóstico adecuado; en A podemos ver un ejemplo de alteración severa de la membrana basal glomerular en un caso de enfermedad de Alport (flechas). En B, las inclusiones laminadas lisosomales en podocitos («cuerpos cebra» –algunas de ellas señaladas con flechas) permitieron plantear el diagnóstico de enfermedad de Fabry, que luego se confirmó con estudios moleculares. En C, la imagen de un caso de membrana basal delgada, condición que solo puede diagnosticarse con el estudio ultraestructural. En D, un caso de nefritis lúpica con extensos depósitos electrón-densos subendoteliales, subepiteliales y transmembrana (flechas), ilustrando mejor el compromiso renal; sin embargo, el diagnóstico y clasificación adecuados de la nefritis lúpica no requiere del estudio ultraestructural. Microscopía electrónica de transmisión, todas con aumento original X 3.000.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Dellys Adriana Álvarez Alvarado, Melissa Alejandra Quintero Picón, Alejandra Taborda-Murillo, Natalia Ortiz-Arango, Sigifredo Ospina Ospina, Luis Fernando Arias" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Dellys Adriana" "apellidos" => "Álvarez Alvarado" ] 1 => array:2 [ "nombre" => "Melissa Alejandra" "apellidos" => "Quintero Picón" ] 2 => array:2 [ "nombre" => "Alejandra" "apellidos" => "Taborda-Murillo" ] 3 => array:2 [ "nombre" => "Natalia" "apellidos" => "Ortiz-Arango" ] 4 => array:2 [ "nombre" => "Sigifredo" "apellidos" => "Ospina Ospina" ] 5 => array:2 [ "nombre" => "Luis Fernando" "apellidos" => "Arias" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885521000040?idApp=UINPBA00004N" "url" => "/16998855/0000005400000004/v1_202109180718/S1699885521000040/v1_202109180718/es/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Adenoid cystic carcinoma and basaloid carcinoma of the breast: A clinicopathological study" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "242" "paginaFinal" => "249" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Vicente Marco, Felip Garcia, Isabel T. Rubio, Teresa Soler, Laura Ferrazza, Ignasi Roig, Inmaculada Mendez, Xavier Andreu, Clarisa González Mínguez, Francesc Tresserra" "autores" => array:10 [ 0 => array:4 [ "nombre" => "Vicente" "apellidos" => "Marco" "email" => array:1 [ 0 => "vmarcomolina@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Felip" "apellidos" => "Garcia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Isabel T." "apellidos" => "Rubio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Teresa" "apellidos" => "Soler" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Laura" "apellidos" => "Ferrazza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Ignasi" "apellidos" => "Roig" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 6 => array:3 [ "nombre" => "Inmaculada" "apellidos" => "Mendez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 7 => array:3 [ "nombre" => "Xavier" "apellidos" => "Andreu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 8 => array:3 [ "nombre" => "Clarisa González" "apellidos" => "Mínguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] ] 9 => array:3 [ "nombre" => "Francesc" "apellidos" => "Tresserra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff0040" ] ] ] ] "afiliaciones" => array:8 [ 0 => array:3 [ "entidad" => "Hospital Quironsalud Barcelona, Pathology, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Quironsalud Barcelona, IOB, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital Universitari Bellvitge/ICO/IDIBELL, Hospitalet de Llobregat, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Consorci Sanitari de Terrassa, Pathology, Terrassa, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Hospital General de Granollers, Pathology, Granollers, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Hospital Parc Tauli, Pathology, Sabadell, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Hospital Mutua de Terrassa, Pathology, Terrassa, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Hospital Universitario Quiron Dexeus, Pathology, Barcelona, Spain" "etiqueta" => "h" "identificador" => "aff0040" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma adenoide quístico y carcinoma basaloide de mama: estudio clinicopatológico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 983 "Ancho" => 1755 "Tamanyo" => 573018 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Different histological patterns in BCB. (A) Solid pattern with central scarring. (B) BCB showing high-grade transformation, basaloid pattern at right and solid pattern at left. (C) BCB with basaloid jigsaw puzzle-like pattern. (D) BCB with basaloid nests showing focal sclerosis. (E) BCB with basaloid nests and collagenous spherule. (F) Solid basaloid nests surrounded by collagenous membranes.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Adenoid cystic carcinomas of the breast (ACCB) are rare tumors, accounting for less than 1% of breast carcinomas. Like their counterpart in the salivary glands, they are composed of a double population of cells, myoepithelial and luminal epithelial cells.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The tumors are predominantly triple negative (ER/PR/HER2) in 90% or more of the cases.</p><p id="par0015" class="elsevierStylePara elsevierViewall">ACCB are usually tumors with a good prognosis, unlike adenoid cystic carcinomas of salivary glands. However, in some ACCB, local recurrences, lymph node metastases and distant metastases occur.</p><p id="par0020" class="elsevierStylePara elsevierViewall">A solid variant of ACCB with basaloid features has been described and is thought to be associated with aggressive behavior.<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">3–6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Several grading systems have been proposed, and predictors of prognosis have been investigated.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,3,6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Molecular characterization of ACCB and ACC of other organs has shown that the majority of the tumors present a recurrent chromosomal translocation t(6;9) (q22-23;p23-24), which is responsible for the fusion of MYB and NFIB and overexpression of MYB. This translocation can be demonstrated with break-apart FISH analysis and the overexpression of MYB with immunohistochemistry (IHC).<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">7–10</span></a>Alternative genetic mechanisms have been described, showing MYL1 rearrangements and MYB amplification, in cases lacking the MYB-NFIB fusion gene.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Rarely, basaloid carcinomas are diagnosed in the breast (BCB) with histological features reminiscent of salivary gland tumors and showing overlapping features with ACCB.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">11</span></a> The diagnostic criteria of these tumors have seldom been addressed and it is unclear whether they are related to ACCB or if their prognosis is unfavorable like that of triple negative carcinomas of no special type (TNC-NST).</p><p id="par0040" class="elsevierStylePara elsevierViewall">The aim of this study was to describe a series of ACCB and BCB, comparing their clinicopathological features and prognosis.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Materials and methods</span><p id="par0045" class="elsevierStylePara elsevierViewall">Databases of the participating institutions were reviewed for cases coded as ACCB and BCB. Hematoxylin and eosin stained slides and paraffin blocks were available. Twenty-six cases were selected after review for one of the authors (VM).</p><p id="par0050" class="elsevierStylePara elsevierViewall">The diagnosis of adenoid cystic carcinoma (ACC) was based on the definition of the 5th edition of the WHO classification.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Classic ACCB are composed of epithelial and myoepithelial neoplastic cells showing a central cribriform area surrounded by a peripheral area with predominant tubular architecture, associated with a basophilic matrix and reduplicated basement membrane material.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Solid basaloid ACCB (SB-ACCB) shows, in addition to the classic features of ACCB, a predominance of solid nests of basaloid cells, with moderate to marked nuclear atypia, variable mitotic counts, and intercalate ducts or ductules.</p><p id="par0065" class="elsevierStylePara elsevierViewall">ACCB with high-grade transformation present areas with loss of the biphasic ductal-myoepithelial differentiation and often show necrosis and high mitotic rate.</p><p id="par0070" class="elsevierStylePara elsevierViewall">BCB, in according to the descriptions of Lamovec et al., were tumors composed of basal-type neoplastic cells, but lacking a cribriform pattern, a dual neoplastic population (epithelial-myoepithelial/basaloid) and stromal deposits of basement membrane-like material.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">11</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">ACCB and BCB were graded following the Nottingham Grading System.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> In addition, ACCB were graded following Foschini's system: grade 1, classic ACCB; grade 2 SB-ACCB; grade 3, ACCB with high-grade transformation.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,6</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">IHC was performed using a Ventana Benchmark LT automated immunostainer (Ventana Medical Systems, Inc., Tucson, AZ, USA) according to standard protocols. The following primary antibodies were used: p63 (clone4A4, Ventana, Inc.); CD 117 (clone 9.7, Ventana, Inc.); MYB (clone EP769Y, Abcam, Cambridge, UK); estrogen receptor (clone SP1, Ventana, Inc.); progesterone receptor (clone PgR636, Ventana, Inc.); HER2 (HER2 Pathway antibody, clone 4B5, Ventana, Inc.). Other antibodies were used in selected cases but are not the object of this report, including CK7, CK 5/6, CK14, neuroendocrine markers (CD56, chromogranin A, synaptophysin), collagen IV, Ki67, and p16.</p><p id="par0085" class="elsevierStylePara elsevierViewall">MYB fluorescence in situ hybridization (FISH) was performed with an MYB dual color break-apart probe (Zytovision, Menarini) designed to detect rearrangements of chromosomal region 6q23.3. A positive result was considered in cases with hybridization patterns other than double signal fusion in more than 15% of cells.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">12</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Clinical data</span><p id="par0090" class="elsevierStylePara elsevierViewall">Clinicopathological features are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. After the pathology review, 17 patients had an ACCB and 9 a BCB. All patients were female. Mean age for ACCB was 59.9 (range, 34–78 year) and for BCB was 58.6 (range, 44–75 years). Size range for ACCB was 12–40<span class="elsevierStyleHsp" style=""></span>mm (mean 26<span class="elsevierStyleHsp" style=""></span>mm) and for BCB was 15–45<span class="elsevierStyleHsp" style=""></span>mm (mean 26<span class="elsevierStyleHsp" style=""></span>mm). Initial surgical treatment was breast conserving surgery (BCS) in 14 (82.3%) ACCB and in 8 (88.8%) BCB. The remaining patients underwent mastectomy. Three patients with ACCB also had a mastectomy following local recurrence and survived 42 months, 171 months, and 193 months, respectively. They are free of disease at the time of publication.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Sentinel lymph node biopsy was performed in 17 cases (9 ACCB and 8 BCB). Six cases underwent axillary lymph node dissection (5 ACCB and 1 BCB). In 1 ACCB, lymph node biopsy was not performed and data were not available in 2 ACCB.</p><p id="par0100" class="elsevierStylePara elsevierViewall">One BCB presented 1 lymph node micrometastasis, 2 BCB presented isolated tumor cells and 1 ACCB presented 2 lymph node metastases. One ACCB with high-grade transformation had axillary recurrence.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Treatment and follow-up</span><p id="par0105" class="elsevierStylePara elsevierViewall">Seven patients received radiotherapy (6 ACCB and 1 BCB), 2 patients received chemotherapy (1 ACCB and 1 BCB) and 5 patients with BCB received radiotherapy and chemotherapy. Ten patients did not receive adjuvant treatment and data were not available in 2 cases.</p><p id="par0110" class="elsevierStylePara elsevierViewall">For 24 patients, mean follow-up was 90 months (range, 12–204 months).</p><p id="par0115" class="elsevierStylePara elsevierViewall">Three patients died of disease. One patient with high-grade ACCB presented skin involvement with ulceration and developed pulmonary metastases. One patient with ACCB and high-grade transformation presented with metastases to the lungs, colon, and brain. One patient with BCB developed pulmonary metastases.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Histopathology and IHC (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>)</span><p id="par0120" class="elsevierStylePara elsevierViewall">We classified 11 of 17 ACCBs as classic type. They presented different architectural patterns, including tubular, cribriform, and solid in different proportions. The cellular aggregates often had geographical configuration. The stroma was, predominantly, fibrous, and often hyalinized. The presence of pseudolumina was characteristic, containing blue mucinous material, and their confluence gave rise to the characteristic cribriform pattern. Occasional ductules were identified among the predominant myoepithelial cells. Cytological atypia was of low grade and mitoses were infrequent (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">Four ACCB cases presented solid basaloid pattern (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). The solid pattern was dominant (>90%). In 3 cases, small foci of classical ACC were observed (pseudolumina, tubules, and cribriform foci). Necrosis was observed in 2 SB-ACCB.</p><p id="par0130" class="elsevierStylePara elsevierViewall">Two cases presented features of ACCB with high-grade transformation (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). In 1 case, the predominant pattern was tubular. High-grade nuclear atypia was noted, with prominent nucleoli and mitotic activity. Infiltration of the overlying skin with ulceration was observed. Perineural invasion was identified in the dermis. The other case had a solid and microcystic pattern, high nuclear atypia and focal lymphovascular invasion. Both patients developed distant metastases and died of disease.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Eleven ACCBs were Nottingham grade 1, 3 were grade 2 and 3 were grade 3.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Nine BCBs showed predominantly solid nests with a geographical pattern reminiscent of SB-ACCB (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The basaloid nests were surrounded by dense fibrous stroma, which was myxoid in a few cases. Occasional lumina were noted, but there was no evidence of ductules, pseudolumina, or a cribriform pattern. One case presented focal squamous differentiation. Most tumors presented nuclear pleomorphism and brisk mitotic activity (>10 mitoses x 10 high power fields). Focal necrosis was observed in 4 cases. All 9 BCB were Nottingham grade 3.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0145" class="elsevierStylePara elsevierViewall">Precursor lesions, such as microglandular adenosis or tubular adenosis, were not observed in our cases.</p><p id="par0150" class="elsevierStylePara elsevierViewall">p63 IHC performed in 16 ACCB showed positivity in 14 cases (87.5%) with a characteristic distribution (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The myoepithelial cells were positive, and the ductules were negative. Positive myoepithelial cells lined the periphery of the tubules and surrounded the pseudolumina, often forming characteristic double rings. Two cases were negative with p63, and 1 was ACCB with high-grade transformation.</p><p id="par0155" class="elsevierStylePara elsevierViewall">p63 was positive in 3 of 9 BCB cases, in 2 cases showing a diffuse pattern, unlike the pattern described in ACCB. One positive case showed focal squamous differentiation.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Seventeen ACCB were stained with MYB antibody, in 15 cases the stain was positive, and in 2 cases the result was uncertain. The pattern of positivity in the myoepithelial cells paralleled the one described with p63. MYB stain in 3 of 9 BC was positive.</p><p id="par0165" class="elsevierStylePara elsevierViewall">In 12 cases, the MYB stain used in core needle biopsies (CNB) was compared with the surgical biopsy. In the positive cases, the stain was more intense and uniform in CNB, probably indicating decreased positivity related to fixation in the surgical biopsies.</p><p id="par0170" class="elsevierStylePara elsevierViewall">CD117 (c-kit) was positive in the ductules of ACC. In BCB, the staining pattern was diffuse.</p><p id="par0175" class="elsevierStylePara elsevierViewall">All ACCB and BCB were triple negative (ER-, PR-, HER2-).</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">MYB FISH</span><p id="par0180" class="elsevierStylePara elsevierViewall">MYB FISH was performed in 25 cases, 16 ACCB and 9 BCB. Thirteen cases were positive for MYB rearrangement, 11 ACCB (73.3%) and 2 BCB (22.2%)(<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). In 10 cases, a typical signal pattern was confirmed (1 orange/green fusion-signal and 1 orange and 1 green split-apart signals); in 3 cases, the pattern observed was a fusion signal and just one green split signal). In 4 ACCB and 1 BCB cases, MYB IHC was expressed and MYB FISH was not rearranged.</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0185" class="elsevierStylePara elsevierViewall">ACC, as defined in the 5th edition of the World Health Organization (WHO) classification, is an invasive carcinoma composed of epithelial and myoepithelial neoplastic cells, associated with a basophilic matrix and reduplicated basement membrane material.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Three subtypes are recognized histologically: classic ACCB, solid-basaloid ACCB and ACCB with high-grade transformation.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0195" class="elsevierStylePara elsevierViewall">Classic ACCB is characterized by the presence of a double population of myoepithelial and epithelial cells. They form tubules, cribriform structures and solid nodules in different proportions. The characteristic feature is the cribriform pattern, formed predominantly by myoepithelial cells surrounding pseudolumina, which are occupied by myxoid stroma and engulfed by the myoepithelium. The luminal cells form small ductules and line tubules. Cytologically, the cells show low-grade atypia and rare mitoses. The stroma shows dense fibrous tissue and reduplicated basement membranes.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">Classic ACCB express myoepithelial markers (p63, CK5/6, CK14) in the majority of the cells. Ductules and tubules are lined by luminal cells, which express CK7 and CD117.</p><p id="par0205" class="elsevierStylePara elsevierViewall">In ACCB, the MYB antibody usually shows nuclear staining in the myoepithelial cells, with a pattern that parallels that of p63. In our series, 15 of 17 cases stained were positive (88.2%). The reported MYB positivity varied between 65 and 89%.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">13</span></a> Positive MYB IHC is characteristic of classic ACC. However, positive results may be also observed in non-salivary gland tumors (breast, thymoma, lymphoma, colon and squamous cell carcinoma).<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">14</span></a> Therefore, MYB IHC has to be interpreted in the appropriate histological context.</p><p id="par0210" class="elsevierStylePara elsevierViewall">ACC of the breast, salivary glands and other organs shows characteristic translocations, t(6;9)(q22-23;p23-24), resulting in the fusion gene MYB-NFIB, which can be demonstrated by FISH or polymerase chain reaction (PCR).<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,13</span></a> In our series, MYB translocation was observed in 11 of 16 cases tested (68.7%). The reported incidence of MYB-NFIB gene fusion in breast ACC varied between 50 and 100%.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">13</span></a> Alternative genetic drivers have been reported in ACC, including MYBL1 rearrangements and MYB amplification.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">15</span></a></p><p id="par0215" class="elsevierStylePara elsevierViewall">Genetic events in the progression of ACCB to high-grade triple-negative breast cancer have been studied in 2 cases, both showing MYB-NFIB fusion gene and additional genetic alterations.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">10</span></a></p><p id="par0220" class="elsevierStylePara elsevierViewall">The solid-basaloid variant of ACC (SB-ACC) was described in the seminal article by Shin and Rosen.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">16</span></a> The 9 cases reported were characterized by the solid growth pattern (>90%) and basaloid appearance, with myxoid or hyalinized stroma. Ductules were present within the tumor islands. Small cysts and pseudoglandular structures were occasionally seen.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">16</span></a> Axillary lymph node metastases were identified in 2 cases but none of the tumors had local or systemic recurrences. D’Alfonso et al. reported a series of 16 cases of SB-ACC, including 5 previously reported by Shin and Rosen.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">4</span></a> They detected MYB rearrangement in 2 of 16 (12.5%) SB-ACC. Two patients had axillary lymph node metastasis, and 2 patients experienced recurrences during follow-up, one local and one distant. Foschini et al. reported 6 cases of SB-ACC. Two patients had lymph node metastases and 2 patients had local recurrences. No distant metastases occurred. Massé et al. reported 17 cases of SB-ACC in which conventional ACC was not present.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">5</span></a> The majority of their cases had MYB expression by IHC (82%), but only 3 cases (19%) had MYB rearrangement by FISH. One SB-ACC had lymph node metastasis, and 2 patients had local recurrences.</p><p id="par0225" class="elsevierStylePara elsevierViewall">In the recent WHO edition of breast tumors, SB-ACC is described as presenting classic ACC and solid nests of basaloid cells, with marked nuclear atypia, high mitotic counts, and necrosis. In our series, we have classified 4 cases as SB-ACC.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Three cases expressed MYB by IHC, and one was not conclusive. MYB rearrangement was present in 2 cases.</p><p id="par0230" class="elsevierStylePara elsevierViewall">ACC with high-grade transformation and dedifferentiation have been described in the salivary glands and rarely in other organs, including the breast.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,17,18</span></a> In these cases high-grade carcinomas-NST were juxtaposed on conventional ACC. This category may overlap with SB-ACC with high-grade features.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">17</span></a> Two of our cases in this category developed distant metastasis.</p><p id="par0235" class="elsevierStylePara elsevierViewall">In 2008 Lamovec et al. described 9 basaloid carcinomas of the breast (BCB) showing neoplastic cells similar to those found in ACC, but lacking distinctive features such as a cribriform pattern, a dual neoplastic population (epithelial-myoepithelial/basaloid) and stromal deposits of basement membrane-like material.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">11</span></a> Following this description and because of their resemblance to ACC and basal cell adenocarcinoma of salivary glands, we have categorized 9 tumors as BCB, acknowledging that these tumors may overlap with SB-ACC and TNC-NST.</p><p id="par0240" class="elsevierStylePara elsevierViewall">ACCBs belong to a group of triple negative carcinomas with a good prognosis in most cases, as opposed to their counterpart in the salivary glands. An important histological difference is perineural invasion, being almost ubiquitous in the salivary glands, but infrequent in ACCB. Occasional local recurrences occur after BCS and may require mastectomy. Lymph node metastasis and visceral metastasis are very unusual.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">2,19–22</span></a></p><p id="par0245" class="elsevierStylePara elsevierViewall">Several grading systems, specifically designed for ACCB, have been proposed. They have also been graded according to the Nottingham grading system.<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">3,6</span></a> As a rule, a solid growth pattern is associated with higher incidence of local recurrence and lymph node metastases; however, this has not been confirmed in all series.<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">4–6</span></a> Foschini et al. proposed a 3 tier grading system (grade 1 corresponds to classical ACC; grade 2 corresponds to SB-ACC; grade 3 corresponds to ACC with high-grade transformation.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,6</span></a> Slodkowska et al. in a multi-institutional series of 108 cases of ACC of breast found that a positive margin, high Nottingham grade, and neovascularization were statistically significant adverse prognostic factors in multivariate analysis.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">3</span></a></p><p id="par0250" class="elsevierStylePara elsevierViewall">Combining the information related to the solid pattern in ACC and BCB in 4 series of 51 cases, including our own, 6 (11.7%) presented local recurrence, 9 (15.6%) presented lymph node involvement (including 1 micrometastasis and 1 with isolated tumor cells, respectively) and 2 (3.9%) cases presented distant metastases.<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">4–6</span></a></p><p id="par0255" class="elsevierStylePara elsevierViewall">When using the Nottingham grading system in our series, 13 ACCB were grade 1, 3 were grade 2, and 2 were grade 3. Two cases, grades 2 and 3, showed evidence of perineural invasion and lymphovascular invasion, respectively, and developed distant metastases. SB-ACCs were grade 2 (2 cases) and grade 3 (1 case) and no distant metastasis developed during follow-up. Nine BCBs were Nottingham grade 3; 2 cases presented lymph node micrometastasis and 1 case presented distant metastasis to the lung.</p><p id="par0260" class="elsevierStylePara elsevierViewall">The differential diagnosis of ACCB and BCB of breast should include other lesions with cribriform and solid patterns.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1–3</span></a> These include cribriform carcinoma, neuroendocrine carcinoma, solid papillary carcinoma (SPC), triple negative carcinoma of no special type (TNC-NST) and basal cell adenoma with cylindroma pattern. Cribriform carcinomas of the breast are low-grade invasive tumors that express hormone receptors. They are HER2-negative and lack myoepithelial layer, except when associated with an in situ component. Neuroendoncrine tumors of the breast may resemble SB-ACC because they have a predominant solid pattern; IHC with different neuroendocrine markers should aid in the differential diagnosis. SPC are characterized by a solid pattern and the presence of fibrovascular cores; they may express neuroendocrine markers and a myoepithelial layer may be focally present at the periphery or be totally absent. TNC-NST are usually not basaloid, but they may present overlapping features with SB-ACCB and ACCB with high-grade transformation, including solid growth, high grade and necrosis.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">23</span></a> In selected cases, IHC for myoepithelial markers, MYB and MYB FISH may be of help.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Genetic studies may show significant differences because TNC-NST are characterized by complex genomes and high mutation rates, including TP53 and PIK3 CA, which are not found in ACCB.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">10</span></a> Rare cases of ACCB coexist with TNC-NST, metaplastic carcinoma and adenomyoepithelioma.<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">24–26</span></a></p><p id="par0265" class="elsevierStylePara elsevierViewall">Basal cell adenomas (BCAs) with a membranous pattern (cylindromas) have been reported in the breast. They are similar to their counterpart in the salivary glands and in the skin<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">27–29</span></a> and are usually well demarcated. They may present a jigsaw puzzle pattern of epithelial basaloid nests, thick basement membranes and hyaline globules, but they lack the characteristic cribriform pattern of ACC and have no atypical nuclear features or significant mitotic activity.</p><p id="par0270" class="elsevierStylePara elsevierViewall">In summary, classic ACCB presents well established histological and IHC features with characteristic cribriform and tubular features and predominance of myoepithelial cells, expressing p63 and MYB. SB-ACC and ACC with high grade transformation should be strictly defined, requiring the presence of focal classic ACC features. The prognosis of most ACC of the breast is excellent, albeit rare cases develop lymph node and distant metastases. Histological features of poor prognosis include high histological grade, perineural invasion, lymphovascular invasion and lymph node metastasis.</p><p id="par0275" class="elsevierStylePara elsevierViewall">In our limited experience, triple negative BCB show little tendency to develop metastasis. Differentiation from TNBC-NST may be important. Further study is needed to delineate their prognosis.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of interest</span><p id="par0280" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1574359" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1418602" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1574360" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1418601" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Materials and methods" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Results" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Clinical data" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Treatment and follow-up" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Histopathology and IHC (Table 2)" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "MYB FISH" ] ] ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-05-31" "fechaAceptado" => "2020-09-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1418602" "palabras" => array:4 [ 0 => "Mammary adenoid cystic carcinoma" 1 => "Solid basaloid adenoid cystic carcinoma" 2 => "High-grade adenoid cystic carcinoma" 3 => "Breast basaloid carcinoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1418601" "palabras" => array:4 [ 0 => "Carcinoma adenoide quístico de mama" 1 => "Carcinoma adenoide quístico basaloide sólido" 2 => "Carcinoma adenoide quístico de alto grado" 3 => "Carcinoma basaloide de mama" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Adenoid cystic carcinoma of the breast (ACCB) is a rare triple negative tumor (TNT) with an excellent prognosis in most cases. Three different histologic types are recognized: classic ACCB, solid basaloid ACCB (SB-ACCB), and ACCB with high-grade transformation. A majority of these tumors show characteristic molecular and immunohistochemical (IHC) features, with fusion of MYB and NFIB genes and overexpression of MYB, respectively. Basaloid carcinomas of the breast (BCB) are infrequently described. They resemble SB-ACCB and TNT of no special type (TNT-NST).</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We have studied the clinicopathological features of 17 ACCB and 9 BCB, investigating the expression of MYB by IHC and the rearrangements of MYB by fluorescence in situ hybridization (FISH).</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">MYB was expressed by IHC in 15 ACCB and in 3 BCB. MYB FISH detected rearrangements in 11 ACCB and in 2 BCB.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">After a mean follow-up of 90 months, with a range of 12–204 months, 2 patients with ACCB with high-grade transformation and 1 patient with BCB developed metastases and died of disease.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In summary, most ACCB have a good prognosis, but tumors with adverse histopathological features may metastasize. BCB may overlap with ACCB and TNT-NST, and their prognosis should be further studied.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El carcinoma adenoide quístico (ACQ) de mama es un tumor triple negativo (TNT) infrecuente, con excelente pronóstico, en muchos de los casos. Se reconocen tres tipos histológicos diferentes: ACQ clásico, ACQ basaloide sólido (SB-ACQ) y ACQ con transformación de alto grado. Una mayoría de estos tumores muestra características moleculares e inmunohistoquímicas (IHC) particulares, con fusión de los genes MYB y NFIB, y sobreexpresión de MYB, respectivamente. Los carcinomas basaloides de mama (BCB) se describen con poca frecuencia. Se asemejan al SB-ACQ y al TNT de tipo no especial (TNT-NST).</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudiamos las características clinicopatológicas de 17 ACQ y nueve BCB, investigando la expresión de MYB mediante IHC y las reorganizaciones de MYB por medio de hibridación fluorescente <span class="elsevierStyleItalic">in situ</span> (FISH).</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La IHC reveló expresiones de MYB en 15 ACQ y en tres BCB. La FISH de MYB detectó reorganizaciones en 11 ACQ y en dos BCB.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Tras un seguimiento medio de 90 meses, con un rango de 12 a 204 meses, dos pacientes con ACQ con transformación de alto grado y una paciente con BCB desarrollaron metástasis y murieron debido a la enfermedad.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A modo de resumen, la mayoría de los tumores ACQ tiene buen pronóstico, pero aquellos con características histopatológicas adversas pueden desarrollar metástasis. Los BCB pueden solaparse con ACQ y TNT-NST, debiendo estudiarse su pronóstico de forma más amplia.</p></span>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1150 "Ancho" => 1755 "Tamanyo" => 622534 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Classic ACCB. (A) Cribriform pattern with pseudolumina. (B) Myoepithelial cells engulfing collagenous stroma and forming pseudolumina. (C) Solid basaloid ACCB showing geographical pattern and collagenous spherules. (D) p63 expressed in myoepithelial cells and negative in luminal cells. (E) MYB expressed in myoepithelial cell. (F) CD117 decorated ductules lined by luminal cells.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 847 "Ancho" => 1505 "Tamanyo" => 521030 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">(A) High-grade ACCB showing ulceration of the skin and (B) perineural invasion. (C) High-grade ACCB showing an ill-defined cribriform pattern with pseudocysts and (D) predominantly solid pattern.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 983 "Ancho" => 1755 "Tamanyo" => 573018 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Different histological patterns in BCB. (A) Solid pattern with central scarring. (B) BCB showing high-grade transformation, basaloid pattern at right and solid pattern at left. (C) BCB with basaloid jigsaw puzzle-like pattern. (D) BCB with basaloid nests showing focal sclerosis. (E) BCB with basaloid nests and collagenous spherule. (F) Solid basaloid nests surrounded by collagenous membranes.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 493 "Ancho" => 1305 "Tamanyo" => 24924 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Break-apart FISH analysis for MYB in ACCB. (A) One wild-type gene locus (yellow signal and break-apart of the second MYB gene locus with separate red and green signals. (B) In 3 cases, an alternative hybridization pattern with a yellow signal and just one green signal.</p>" ] ] 4 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">ACCB: adenoid cystic carcinoma of the breast; BCB: basaloid carcinoma of the breast.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">ACCB \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">BCB \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">N</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Age (years, mean)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">58.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Tumor size (mm, mean)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Surgery</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Breast conserving \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mastectomy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Lymph node status</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (pN1a) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 [1pN1a, 2 pN0(i+)] \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Nottingham grade</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grade 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grade 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grade 3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Perineural invasion</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Lymphovascular invasion</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Distant metastases</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">NED</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">DOD</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2697737.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Follow-up in 15 cases; NED: no evidence of disease; DOD: dead of disease.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Clinicopathological features of adenoid cystic carcinomas and basaloid carcinomas of the breast.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">ACCB: adenoid cystic carcinoma of the breast; BCB: basaloid carcinoma of the breast; SB-ACCB: solid basaloid adenoid cystic carcinoma of the breast; HG-ACCB: high grade adenoid cystic carcinoma of the breast; NI: not interpretable; ND: not done.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cases \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tumor type \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MYB IHC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MYB FISH \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SB-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SB-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 07 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HG-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HG-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SB-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Case 26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SB-ACCB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2697736.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Correlation of tumor type and MYB status determined by IHC and FISH.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0150" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "WHO Classification of Tumors Editorial Board. 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Journal Information
Original
Adenoid cystic carcinoma and basaloid carcinoma of the breast: A clinicopathological study
Carcinoma adenoide quístico y carcinoma basaloide de mama: estudio clinicopatológico
Vicente Marcoa,
, Felip Garciaa, Isabel T. Rubiob, Teresa Solerc, Laura Ferrazzac, Ignasi Roigd, Inmaculada Mendeze, Xavier Andreuf, Clarisa González Mínguezg, Francesc Tresserrah
Corresponding author
a Hospital Quironsalud Barcelona, Pathology, Barcelona, Spain
b Hospital Quironsalud Barcelona, IOB, Barcelona, Spain
c Hospital Universitari Bellvitge/ICO/IDIBELL, Hospitalet de Llobregat, Spain
d Consorci Sanitari de Terrassa, Pathology, Terrassa, Spain
e Hospital General de Granollers, Pathology, Granollers, Spain
f Hospital Parc Tauli, Pathology, Sabadell, Spain
g Hospital Mutua de Terrassa, Pathology, Terrassa, Spain
h Hospital Universitario Quiron Dexeus, Pathology, Barcelona, Spain