metricas
covid
Buscar en
Vacunas (English Edition)
Toda la web
Inicio Vacunas (English Edition) Simulator of interactions of the human immune system: Description of the model f...
Journal Information
Vol. 23. Issue 1.
Pages 1-16 (January - April 2022)
Share
Share
Download PDF
More article options
Visits
1
Vol. 23. Issue 1.
Pages 1-16 (January - April 2022)
Special article
Simulator of interactions of the human immune system: Description of the model for the life cycle of human papillomavirus type 16 and therapeutic vaccines
Simulador de interacciones del sistema inmune humano: descripción del modelo para el ciclo de vida del virus de papiloma humano tipo 16 y vacunas terapéuticas
Visits
1
M.E. Escobar Ospina
Departamento de Ingeniería – Sistemas y Computación, Universidad Nacional, Bogotá, Colombia
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (6)
Show moreShow less
Abstract
Objective

To present an artificial life model that simulates behaviours based on interactions that emerge between the human immune system, the life cycle of human papillomavirus type 16, some types of therapeutic virus type 16, and some types of therapeutic vaccines.

Materials and methods

Using the approach of complex systems theories and biological systems, we created an artificial life model that allowed us to simulate virtual patient immune systems that develop infectious viral processes. These patients receive a therapeutic vaccine capable of releasing the necessary doses autonomously, once the model establishes that the immune system has outgrown its ability to counteract lesions caused by persistent viral infection.

Conclusions

The methodology developed provides independence to the modelling of each of the components that make up each of the components that constitute the three proposed domains and reflects the dynamics that emerge from their interactions, thus ensuring the corresponding feedback processes. With this work, a knowledge base is established that allows us to define the conceptual design, determine the general logic, and produce the dynamics of implementation of the HPV16-ALIFE model.

Keywords:
Artificial life
Artificial immune system
Cervical cancer
Hpv16
Simulation model
Therapeutic vaccine
Resumen
Objetivo

Presentar un modelo de vida artificial que simula comportamientos basados en interacciones que emergen entre el sistema inmune humano, ciclo de vida del virus de papiloma humano tipo 16, y algunos tipos de vacunas terapéuticas.

Materiales y métodos

Bajo el enfoque de teorías de sistemas complejos y sistemas biológicos, creamos un modelo de vida artificial que nos permite simular sistemas inmunes de pacientes virtuales que desarrollan procesos virales infecciosos. Estos pacientes reciben una vacuna terapéutica capaz de liberar las dosis necesarias de forma autónoma, una vez el modelo establece que el sistema inmune ha superado su capacidad de contrarrestar lesiones causadas por la infección viral persistente.

Conclusiones

La metodología desarrollada proporciona independencia al modelamiento de cada uno de los componentes que integran los tres dominios propuestos y refleja la dinámica que surge a partir de sus interacciones, garantizando de esta forma los procesos de retroalimentación correspondientes. Con este trabajo se establece una base de conocimiento que nos permite definir el diseño conceptual, determinar la lógica general, y producir la dinámica de implementación del modelo HPV16-ALIFE.

Palabras clave:
Vida artificial
Sistema inmune artificial
Cáncer cérvix
Hpv16
Modelo simulación
Vacuna terapéutica

Article

These are the options to access the full texts of the publication Vacunas (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Vacunas (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos