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array:23 [ "pii" => "S0001651906787271" "issn" => "00016519" "doi" => "10.1016/S0001-6519(06)78727-1" "estado" => "S300" "fechaPublicacion" => "2006-10-01" "aid" => "78727" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2006;57:355-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1787 "formatos" => array:3 [ "EPUB" => 57 "HTML" => 870 "PDF" => 860 ] ] "itemSiguiente" => array:18 [ "pii" => "S0001651906787283" "issn" => "00016519" "doi" => "10.1016/S0001-6519(06)78728-3" "estado" => "S300" "fechaPublicacion" => "2006-10-01" "aid" => "78728" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2006;57:359-63" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2423 "formatos" => array:3 [ "EPUB" => 49 "HTML" => 1577 "PDF" => 797 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Análisis epidemiológico de 72 carcinomas de fosas y senos paranasales" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "359" "paginaFinal" => "363" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Epidemiologic analysis of 72 carcinomas of the nasal cavity and paranasal sinuses" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.R. Gras Cabrerizo, C. Orús Dotú, J.R. Montserrat Gili, J.M. Fabra Llopis, X. León Vintro, J. De Juan Beltrán" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.R." "apellidos" => "Gras Cabrerizo" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Orús Dotú" ] 2 => array:2 [ "nombre" => "J.R." "apellidos" => "Montserrat Gili" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Fabra Llopis" ] 4 => array:2 [ "nombre" => "X." "apellidos" => "León Vintro" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "De Juan Beltrán" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651906787283?idApp=UINPBA00004N" "url" => "/00016519/0000005700000008/v1_201304231452/S0001651906787283/v1_201304231452/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S000165190678726X" "issn" => "00016519" "doi" => "10.1016/S0001-6519(06)78726-X" "estado" => "S300" "fechaPublicacion" => "2006-10-01" "aid" => "78726" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2006;57:350-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3924 "formatos" => array:3 [ "EPUB" => 54 "HTML" => 2258 "PDF" => 1612 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "El colgajo en “J” de la crus lateral del cartílago alar en el tratamiento del colapso de la válvula nasal" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "350" "paginaFinal" => "354" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Lateral crural “J” flap repair to correct nasal valve collapse" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Franco Gutiérrez, J.P. Rodrigo Tapia, M.P. Cuesta Albalad" "autores" => array:4 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Franco Gutiérrez" ] 1 => array:2 [ "nombre" => "J.P." "apellidos" => "Rodrigo Tapia" ] 2 => array:2 [ "nombre" => "J.P." "apellidos" => "Rodrigo Tapia" ] 3 => array:2 [ "nombre" => "M.P." "apellidos" => "Cuesta Albalad" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000165190678726X?idApp=UINPBA00004N" "url" => "/00016519/0000005700000008/v1_201304231452/S000165190678726X/v1_201304231452/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Resultados de la aplicación de mitomicina en la dacriocistorrinostomía endonasal y endocanalicular con láser diodo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "355" "paginaFinal" => "358" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.A. Alañón Fernández, F.J. Alañón Fernández, A. Martínez Fernández, M. Cárdenas Lara" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M.A." "apellidos" => "Alañón Fernández" "email" => array:1 [ 0 => "miguelaaf@msn.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "F.J." "apellidos" => "Alañón Fernández" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Martínez Fernández" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Cárdenas Lara" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Instituto Internacional de Vías Nasolagrimales. Jaén" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1." "correspondencia" => "Correspondencia: Miguel Ángel Alañón Fernández Plaza de los Jardinillos, 8-1ºD 23001 Jaén" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Results the application of mitomicyn during endonasal and endocanalicular dacryocystorhinostomy by diode laser" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-05-26" "fechaAceptado" => "2006-07-14" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec81752" "palabras" => array:4 [ 0 => "Dacriocistorrinostomía endonasal" 1 => "endocanalicular" 2 => "Mitomicina C" 3 => "Láser diodo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec81753" "palabras" => array:4 [ 0 => "Endonasal" 1 => "endocanalicular dacryocistorhinostomy" 2 => "Mitomicyn C" 3 => "Diode laser" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar el beneficio, efectos secundarios y seguridad de la aplicación de mitomicina C (MMC) de forma intraoperatoria, durante la realización de una dacriocistorrinostomía endonasal y endocanalicular con láser diodo (TLA-ELA DCR).</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realizó un estudio prospectivo randomizado, intervencional y doble ciego. Se estudiaron 200 pacientes a 150 pacientes se les aplicó MMC intraoperatoria (0,4 mg/0,2 ml) durante un tiempo de 5 minutos, mediante un apósito de acetato de polivinilo que se coloca sobre la osteotomía. En el resto de pacientes fueron revisados a las 24 horas, 10 días, 1, 3 y 6 meses postcirugía. Se estudió el aspecto endoscópico y las posibles complicaciones. Los resultados se comparan mediante el test de Chi-cuadrado con la corrección de Yates. Se estudió la presencia o ausencia de efectos secundarios por la aplicación de MMC.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El seguimiento medio fue 15,25 meses (rango= 6-21 meses). El porcentaje de alteraciones por cicatrización excesiva fue del 21,77% y del 8,03%, en los pacientes sin y con MMC respectivamente. La diferencia fue estadísticamente significativa (p=0,02). No hubo efectos secundarios por la aplicación de MMC.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La aplicación de MMC intraoperatoria tópica durante TLA-ELA DCR disminuye los hallazgos patológicos por cicatrización del área periférica al nuevo drenaje sin producir efectos secundarios.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Aim of the study</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the effects, secondary effects and security of the intrasurgical application of mitomicyn C during endonasal and endocanalicular dacryocystorhinostomy with diode laser (TLA-ELA DCR).</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We carried out a randomized, prospective, interventional and double blind study in 200 patients: intrasurgical mitomicyn C was applied in 150 of then (0.4 mgr/0.2 ml) for 5 minutes by means of a polivinil acetate dressing over the osteotomy. In other 50 patients MMC was not used we followed up at 24 hours, 10 days and 1, 3 and 6 months after surgery. Endoscopic aspects and possible complications were valued. The results were compared using the Chi-squared test with the Yates correction. We looked for the presence or abscense of secondary effects in the application of mitomicyn C.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The average follow up was 15.25 months (range 6 to 21 months). The percentages of alterations for excesive scarring were 21.77% in patients without and MAC 8.03% in the ones MMC. The difference was statisticaly significant (p= 0.02). We did not find secondary effects due to application of mitomcyn.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Intrasurgical application of topical MMC during TLA-ENL DCR reduces the number of pathological findings due to scarring of the surrouding area of the new drainage without secondary effects.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dacriocistorrinostomía externa con mitomicina C. Valoración clínica y anatómica mediante tomografía computerizada helicoidal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F.J. Gonzalvo" 1 => "I. Fuertes" 2 => "F.J. 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Oda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthal Plast Reconstr Surg" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "119" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10749158" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sinus surgery: does mitomycin C reduce stenosis?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.R. Ingrans" 1 => "M.S. Volk" 2 => "B.S. Biesman" 3 => "M.M. Pankratov" 4 => "S.M. Shapshay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Laryngoscope" "fecha" => "1998" "volumen" => "108" "paginaInicial" => "883" "paginaFinal" => "886" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9628504" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00016519/0000005700000008/v1_201304231452/S0001651906787271/v1_201304231452/es/main.assets" "Apartado" => array:4 [ "identificador" => "5888" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Investigación clínica" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00016519/0000005700000008/v1_201304231452/S0001651906787271/v1_201304231452/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651906787271?idApp=UINPBA00004N" ]
