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array:24 [ "pii" => "S0210480609741373" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74137-3" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74137" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:242-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1578 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 860 "PDF" => 708 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609741385" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74138-5" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74138" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:249-57" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1392 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 794 "PDF" => 592 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Factores pronósticos en la supervivencia de los pacientes con carcinoma transicional de vejiga tratados con cistectomía radical" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "249" "paginaFinal" => "257" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prognostic factors for survival in patients with transitional baldder cancer treated with radical cystectomy" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan I. Monzó Gardiner, Felipe Herranz Amo, José M. Díez Cordero, Ramiro Cabello Benavente, Ángel Silmi Moyano, Carlos Hernández Fernández" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Juan I." "apellidos" => "Monzó Gardiner" ] 1 => array:2 [ "nombre" => "Felipe" "apellidos" => "Herranz Amo" ] 2 => array:2 [ "nombre" => "José M." "apellidos" => "Díez Cordero" ] 3 => array:2 [ "nombre" => "Ramiro" "apellidos" => "Cabello Benavente" ] 4 => array:2 [ "nombre" => "Ángel" "apellidos" => "Silmi Moyano" ] 5 => array:2 [ "nombre" => "Carlos" "apellidos" => "Hernández Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741385?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741385/v1_201304251925/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480609741361" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74136-1" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74136" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:235-41" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1692 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 979 "PDF" => 707 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Mecanismo fisiopatológico de los sofocos-sudores inducidos por deprivación androgénica en el carcinoma prostático" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "235" "paginaFinal" => "241" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Physiopathological mechanism of hot flushes-perspiration induced by androgen deprivation in prostate carcinoma" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Santiago Vilar Gónzalez, Francesc Montañá Puig, Mª Victoria Villas Sánchez, Mª del Mar Sevillano Capellán, Manuel Martos Aguayo, Sebastiá. Sabater Martí" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Santiago" "apellidos" => "Vilar Gónzalez" ] 1 => array:2 [ "nombre" => "Francesc" "apellidos" => "Montañá Puig" ] 2 => array:2 [ "nombre" => "Mª" "apellidos" => "Victoria Villas Sánchez" ] 3 => array:2 [ "nombre" => "Mª" "apellidos" => "del Mar Sevillano Capellán" ] 4 => array:2 [ "nombre" => "Manuel" "apellidos" => "Martos Aguayo" ] 5 => array:2 [ "nombre" => "Sebastiá." "apellidos" => "Sabater Martí" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741361?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741361/v1_201304251925/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Avances sobre la influencia del tejido adiposo en el adenocarcinoma de próstata" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "242" "paginaFinal" => "248" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Constanza López Fontana, M. Eugenia Maselli Artola, M. Cristina Vanrell Rodríguez, Nicolás A. Di Milta Mónaco, Rafael Pérez Elizalde, José D. López Laur" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Constanza" "apellidos" => "López Fontana" "email" => array:1 [ 0 => "investigacioncap@yahoo.com.ar" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Eugenia Maselli Artola" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Cristina Vanrell Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Nicolás A." "apellidos" => "Di Milta Mónaco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Rafael" "apellidos" => "Pérez Elizalde" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "José D." "apellidos" => "López Laur" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Cátedra Clínica Urológica. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza. Argentina" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Laboratorio de Enfermedades Metabólicas y Cáncer. Facultad de Farmacia y Bioquímica. Universidad Juan Agustín Maza. Mendoza. Argentina" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dra. Constanza López Fontana Acceso Este 2245 (Lateral Sur) San José, Guaymallén. Mendoza Argentina. CP: 5519. Fax: 54-261-4299350" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Advances on the influence of adipose tissue on prostate cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88867" "palabras" => array:4 [ 0 => "Tejido adiposo" 1 => "Adipoquinas" 2 => "Obesidad" 3 => "Cáncer de próstata" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88868" "palabras" => array:4 [ 0 => "Adipose tissue" 1 => "Adipokines" 2 => "Obesity" 3 => "Prostate cancer" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numerosos estudios han intentado interpretar la asociación entre la obesidad y el cáncer de próstata (CaP), aunque los resultados no han sido concluyentes debido a que existe una gran dificultad para evaluar sus efectos de sobre el desarrollo del CaP. Dicha dificultad radica en que no solo implica un exceso de grasa corporal, sino también una alteración de diversos parámetros fisiológicos que aumentan la agresividad del tumor.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizar una puesta al día sobre el rol del tejido adiposo en el desarrollo del CaP. Material y métodos: se realizó una búsqueda bibliográfica y lectura compresiva de artículos relacionados con “tejido adiposo”, “obesidad”, “adipoquinas” y “cáncer de próstata” en Pubmed y revistas científicas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudios recientes indican que la obesidad influiría en la carcinogénesis prostática mediante factores promotores (andrógenos, leptina, VEGF, IL-6, insulina e IGF-1) y factores protectores (adiponectina e IGFBP-3). Los mecanismos potenciales mediante los cuales la obesidad podría iniciar, promover o favorecer la progresión del CaP son los bajos niveles de testosterona y altos niveles de estrógenos, el síndrome metabólico coexistente, el aumento en la secreción de leptina, VEGF, IL-6 y TNF-αy disminución de adiponectina, y la excesiva ingesta de grasas saturadas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El exceso de tejido adiposo en el organismo podría promover la progresión del CaP, más que ser un factor de riesgo. Sin embargo, futuros estudios son necesarios para esclarecer aún más la relación entre las adipoquinas y el CaP con el fin de desarrollar nuevas medidas de prevención y tratamiento de este tumor.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Numerous studies have investigated the association between obesity and prostate cancer (CaP), although the results have not been concluding due to the great difficulty to evaluate the effects of obesity on the development of this type of tumor.</p> <span class="elsevierStyleSectionTitle">The aim of this study</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">was to carry out a comprehensive over-view of the existing evidence about the role of adipose tissue in the prostate carcinogenesis. Recent evidence suggests that androgens, leptin, IL-6, VEGF, insulin and IGF-1 may play a role in PC progression, while adiponectin and IGFBP-3 may act as “anti- prostatic cancer” adipokines. The potential mechanisms by which obesity may initiate, promote or facilitate the progression of CaP are low levels of testosterone and high levels of estrogen, coexisting metabolic syndrome, increased secretion of leptin, VEGF, IL-6 and TNF-αand decreased adiponectin, and excessive intake of saturated fat.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Obesity may promote the progression of established PC rather than being a risk factor for the development of this tumour. However, additional studies are needed to clarify the relationship between adipokines and PC before developing new preventive or treatment strategies for this tumor.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:49 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity and prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.J. Freedland" 1 => "W.J. 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