Compartir
array:23 [ "pii" => "S0210480608739731" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73973-1" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73973" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:961-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1141 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 714 "PDF" => 421 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480608739743" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73974-3" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73974" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:968-75" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1287 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 830 "PDF" => 449 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Prostatectomía radical: comparación de los resultados obtenidos durante las curvas de aprendizaje de la técnica laparoscópica pura y de la técnica asistida por robot con la prostatectomía radical retropúbica" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "968" "paginaFinal" => "975" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Radical prostatectomy: evaluation of learning curve outcomes laparoscopic and robotic-assisted laparoscopic techniques with radical retropubic prostatectomy" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.P. Caballero Romeu, J. Palacios Ramos, J.G. Pereira Arias, M. Gamarra Quintanilla, A. Astobieta Odriozola, G. Ibarluzea González" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.P." "apellidos" => "Caballero Romeu" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Palacios Ramos" ] 2 => array:2 [ "nombre" => "J.G." "apellidos" => "Pereira Arias" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Gamarra Quintanilla" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Astobieta Odriozola" ] 5 => array:2 [ "nombre" => "G." "apellidos" => "Ibarluzea González" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739743?idApp=UINPBA00004N" "url" => "/02104806/0000003200000010/v1_201304251917/S0210480608739743/v1_201304251917/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S021048060873972X" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73972-X" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73972" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Actas Urol Esp. 2008;32:957-60" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1380 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 871 "PDF" => 503 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Uso de antimuscarínicos en pacientes con STUI-HBP y síntomas de VHA: maestría clínica y resistencia a perder el miedo al riesgo de retención urinaria" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "957" "paginaFinal" => "960" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.L. Ruiz Cerdá" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Ruiz Cerdá" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021048060873972X?idApp=UINPBA00004N" "url" => "/02104806/0000003200000010/v1_201304251917/S021048060873972X/v1_201304251917/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Características clínicas e histopatológicas del cáncer de próstata diagnosticado a partir de la tercera biopsia" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "961" "paginaFinal" => "967" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.P. Bahílo Mateu, M. Ramírez Backhaus, M. Trassierra Villa, C. Di Capua Sacoto, S. Arlandis Guzmán, J.F. Jiménez Cruz" "autores" => array:6 [ 0 => array:4 [ "nombre" => "M.P." "apellidos" => "Bahílo Mateu" "email" => array:1 [ 0 => "pilarbahilo@comv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Ramírez Backhaus" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Trassierra Villa" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Di Capua Sacoto" ] 4 => array:2 [ "nombre" => "S." "apellidos" => "Arlandis Guzmán" ] 5 => array:2 [ "nombre" => "J.F." "apellidos" => "Jiménez Cruz" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Urología. Hospital Universitario La Fe. Valencia" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dra. M.P. Bahílo Mateu Servicio de Urología. Hospital Universitario La Fe Avda. Campanar, 21- 46009. Valencia. Tel.: 963 862 700" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical features and histopathology of prostate cancer diagnosed from the third biopsy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-04-01" "fechaAceptado" => "2008-07-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88742" "palabras" => array:2 [ 0 => "Biopsia prostática de repetición" 1 => "Cáncer de próstata" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88741" "palabras" => array:2 [ 0 => "Repeated prostate biopsy" 1 => "Prostate cancer" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar las características histopatológicas y clínicas de los tumores diagnosticados a partir de terceras biopsias para valorar la relevancia clínica de éstos y descartar el sobrediagnóstico en el cáncer de próstata.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisamos las historias clínicas de 61 pacientes con al menos tres o más biopsias de próstata transrectales, sextantes o de saturación según el esquema preestablecido, desde el año 2000 al 2006. Las variables analizadas son: edad del paciente, PSA, cociente PSA libre/PSA total, PSA densidad, tacto rectal, volumen prostático, hallazgos ecográficos y lesión premaligna fuertemente asociadas a la presencia de tumor en biopsias previas. Y estudiamos la anatomía patológica de los tumores diagnosticados a partir de la tercera biopsia, abordaje terapéutico y su evolución con un seguimiento mínimo de 3 meses.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De 61 pacientes con más de tres biopsias, a 15 pacientes se les diagnostica cáncer (24,6%) en la tercera biopsia. A 14 se les realiza nueva biopsia (cuarta), encontrando tumor en 5 de ellos (35,7%). Se realiza quinta biopsia en 2 pacientes siendo positiva en uno de ellos (50%). Según los resultados de la biopsia, 6 pacientes presentaban criterios de cáncer clínicamente no significativo (28,6%). En todos los pacientes se procedió a tratamiento curativo: 5 braquiterapia, 6 radioterapia externa y a 10 se les realizó una prostatectomía radical, que evidenció tumores clínicamente significativos: 2 tumores pT2b y 7 tumores pT2c sin invasión de los márgenes quirúrgicos y con un excelente control de la enfermedad tras un seguimiento mínimo de 13 meses y un pT4 por invasión del cuello vesical.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En nuestro medio, la tercera, cuarta y quinta biopsia alcanza una positividad del 34,42% y se corresponde con tumores que se benefician de un tratamiento con intención curativa.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study of histological and clinical features of prostate cancer diagnosed after three or more prostate biopsies in order to assess its clinical relevance and to discard the overdiagnosis of prostate cancer.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We reviewed the clinical records of 61 patients who underwent three or more prostate biopsies between January 2000 and December 2006. The analyzed variables were: age, PSA level, free/total PSA ratio, PSA density, digital rectal examination, prostate volume, sonographic findings and previous malignant lesion strongly associated to the presence of tumor on previous biopsy. We studied the pathology of the tumors diagnosed from the third biopsy, therapeutical approach and its evolution with a minimum follow-up of 3 months.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fifteen out of 61 patients with more than three biopsies had prostate cancer (24,59%) in the third biopsy, 5 out of 14 patients with 4 biopsies (35,71%) and 1 of the 2 cases (50%) who underwent a fifth biopsy. According to the results of biopsy, 6 patients met the criteria of clinically insignificant cancer (28,57%). Curative treatment was performed in all patients: brachytherapy in 5, external beam radiotherapy in 6 and radical prostatectomy in 10. Clinically significant tumors were found in all cases: 2 pT2b tumors and 7 pT2c tumors with negative surgical margins and with an excellent control of the cancer after a minimum follow up of 13 months, and one pT4 tumor with bladder neck infiltration.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In our practice, overall detection rate of the third, fourth and fifth biopsy is 34,42% corresponding with tumors that could benefit from curative treatment.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "<a class="elsevierStyleInterRef" href="http://www.ine.es/jaxi/tabla.do">http://www.ine.es/jaxi/tabla.do.</a> 1 de septiembre de 2008" ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Digital rectal examination for detecting prostate cancer at prostate specific antigen levels of 4 ng/ml or less" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.F. Carvalhal" 1 => "D.S. Smith" 2 => "D.E. Mager" 3 => "W.J. Catalona" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1999" "volumen" => "161" "paginaInicial" => "835" "paginaFinal" => "839" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10022696" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of a nomogram that predicts the probability of a positive prostate biopsy in men with an abnormal digital rectal examination and a prostate-specific antigen between 0 and 4 ng/ml" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.A. Eastham" 1 => "R. May" 2 => "J.L. Robertson" 3 => "O. Sartor" 4 => "M.W. Kattan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Urology" "fecha" => "1999" "volumen" => "54" "paginaInicial" => "708" "paginaFinal" => "713" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of digital rectal examination and serum prostate specific antigen (PSA) in the early detection of prostate cancer: results of a multicentre clinical trial of 6,630 men" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.J. Catalona" 1 => "J.P. Richie" 2 => "F.R. Ahmann" 3 => "M.A. Hudson" 4 => "P.T. Scardino" 5 => "R.C. Flanigan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1994" "volumen" => "151" "paginaInicial" => "1283" "paginaFinal" => "1290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7512659" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characteristics of screening detected prostate cancer in men 50 to 66 years old with 3 to 4 ng/mL. Prostate specific antigen" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Lodding" 1 => "G. Aus" 2 => "S. Bergdahl" 3 => "R. Frosing" 4 => "H. Lilja" 5 => "C.G. Pihl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1998" "volumen" => "159" "paginaInicial" => "899" "paginaFinal" => "903" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9474178" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "To color doppler image the prostate or not: that is the question" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.A. Alexander" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiology.195.1.7534428" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "1995" "volumen" => "195" "paginaInicial" => "11" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7534428" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate cancer and the role of color doppler US" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I.M. Kelly" 1 => "W.R. Lees" 2 => "D. Rickards" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiology.189.1.7690489" "Revista" => array:7 [ "tituloSerie" => "Radiology" "fecha" => "1993" "volumen" => "189" "paginaInicial" => "153" "paginaFinal" => "159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7690489" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109707024825" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The sextant protocol for ultrasound-guided core biopsy cores of the prostate understimates the presence of cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Norberg" 1 => "L. Egevad" 2 => "L. Holmberg" 3 => "P. Sparen" 4 => "B.J. Norlen" 5 => "C. Busch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0090-4295(97)00306-3" "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "1997" "volumen" => "50" "paginaInicial" => "562" "paginaFinal" => "568" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9338732" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systematic transrectal ultrasound-guided biopsy of the prostate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.J. Garber" 1 => "S.L. Goldenberg" 2 => "P.L. Cooperberg" 3 => "A.d. Wong" 4 => "J.H. Bilby" 5 => "J.R. Mathieson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Can Assoc Radiol J" "fecha" => "1994" "volumen" => "45" "paginaInicial" => "387" "paginaFinal" => "400" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7922720" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Parasagittal biopsies add minimal information in repeat saturation prostate biopsy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.R. Patel" 1 => "J.S. Jones" 2 => "J. Rabets" 3 => "G. DeOreo" 4 => "C.D. Zippe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "2004" "volumen" => "63" "paginaInicial" => "87" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14751355" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elevated serum prostate specific antigen levels in conjuntion with an initial prostatic biopsy negative for carcinoma: who should undergo a repeat biopsy?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.C. Durkan" 1 => "D.R. Greene" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BJU Int" "fecha" => "1999" "volumen" => "83" "paginaInicial" => "34" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10349413" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive value of prostatic adenocarcinoma after a negative prostate biopsy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.C. Park" 1 => "T. Mai" 2 => "N. Roustan Delatour" 3 => "C. Morash" 4 => "I. Cagiannos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1464-410X.2006.06453.x" "Revista" => array:6 [ "tituloSerie" => "BJU Int" "fecha" => "2006" "volumen" => "98" "paginaInicial" => "986" "paginaFinal" => "988" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17034600" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate biopsy: who, how and when. An update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Djavan" 1 => "S. Milani" 2 => "M. Remzi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Can J Urol" "fecha" => "2005" "volumen" => "12" "paginaInicial" => "44" "paginaFinal" => "52" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15780165" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673699123237" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Djavan" 1 => "V. Ravery" 2 => "A. Zlotta" 3 => "P. Dobronski" 4 => "M. Dobrovits" 5 => "M. Fakhari" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2001" "volumen" => "166" "paginaInicial" => "1679" "paginaFinal" => "1683" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11586201" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical, biochemical and pathological features of initial and repeat transrectal ultrasonography prostate biopsy positive patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.S. Yuen" 1 => "W.K. Lau" 2 => "L.G. Ng" 3 => "P.H. Tan" 4 => "L.W. Khin" 5 => "C.W. Cheng" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1442-2042.2003.00772.x" "Revista" => array:7 [ "tituloSerie" => "Int J Urol" "fecha" => "2004" "volumen" => "11" "paginaInicial" => "225" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15028101" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S014067360861171X" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate cancer diagnosed after repeat biopsies have a favorable pathological outcome but similar recurrence rate" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Lopez-Corona" 1 => "M. Ohori" 2 => "T.M. Wheeler" 3 => "V.E. Reuter" 4 => "P.T. Scardino" 5 => "M.W. Kattan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0022-5347(05)00350-2" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2006" "volumen" => "175" "paginaInicial" => "923" "paginaFinal" => "930" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16469581" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate cancer detection and tumor characteristics in men with multiple biopsy sessions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Lujan" 1 => "A. Paez" 2 => "C. Santonja" 3 => "T. Pascual" 4 => "I. Fernandez" 5 => "A. Berenguer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Prostate" "fecha" => "2004" "volumen" => "7" "paginaInicial" => "238" "paginaFinal" => "242" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Single small focus of prostate adenocarcinoma (< or = 1mm and too small for grading) and clinical significant disease after radical prostatectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Taverna" 1 => "P. Colombo" 2 => "M. Seveso" 3 => "G. Giusti" 4 => "A. Piccinelli" 5 => "A. Benetti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Ital Urol Androl" "fecha" => "2006" "volumen" => "78" "paginaInicial" => "57" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16929604" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate Needle Biopsies Containing Prstatic Intraepithelial Neoplasia or Atypical Foci Suspicious for Carcinom: Implications for Patient Care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.I. Epstein" 1 => "M. Herawi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0022-5347(05)00337-X" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "175" "paginaInicial" => "820" "paginaFinal" => "834" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16469560" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lead times and overdetection due to prostate specific antigen screening: estimates from the European Randomized Study of Screening for Prostate Cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Draisma" 1 => "R. Boer" 2 => "S.J. Otto" 3 => "I.W. van der Cruijsen" 4 => "R.A. Damhuis" 5 => "F.H. Schroder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2003" "volumen" => "95" "paginaInicial" => "868" "paginaFinal" => "878" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12813170" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of prostate cancer among men with a prostate specific antigen level = 4 ng per milliliter" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I.M. Thompson" 1 => "D.K. Pauler" 2 => "P.J. Goodman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "2239" "paginaFinal" => "2246" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cliniclly significant prostate cancer found incidentallly in radical cystoprostatectomy specimens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Abdelhady" 1 => "A. Abusamra" 2 => "S.E. Pautler" 3 => "J.L. Chin" 4 => "J.I. Izawa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1464-410X.2006.06558.x" "Revista" => array:6 [ "tituloSerie" => "BJU Int" "fecha" => "2006" "volumen" => "99" "paginaInicial" => "326" "paginaFinal" => "329" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17026595" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003200000010/v1_201304251917/S0210480608739731/v1_201304251917/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003200000010/v1_201304251917/S0210480608739731/v1_201304251917/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739731?idApp=UINPBA00004N" ]
