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array:24 [ "pii" => "S0210480609741385" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74138-5" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74138" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:249-57" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1392 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 794 "PDF" => 592 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609741397" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74139-7" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74139" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:258-69" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1538 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 889 "PDF" => 641 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Factores predictivos de neoplasia vesical metacrónica tras nefroureterectomía" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "258" "paginaFinal" => "269" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Predictive factors of metachronous bladder neoplasm after nephroureterectomy" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Andres Rodriguez Alonso, Alfonso Gonzalez Blanco, Alfonso Barbagelata Lopez, Salvador Pita Fernandez, Carlos Bonelli Martin, Miguel A. Cuerpo Perez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Andres" "apellidos" => "Rodriguez Alonso" ] 1 => array:2 [ "nombre" => "Alfonso" "apellidos" => "Gonzalez Blanco" ] 2 => array:2 [ "nombre" => "Alfonso" "apellidos" => "Barbagelata Lopez" ] 3 => array:2 [ "nombre" => "Salvador" "apellidos" => "Pita Fernandez" ] 4 => array:2 [ "nombre" => "Carlos" "apellidos" => "Bonelli Martin" ] 5 => array:2 [ "nombre" => "Miguel A." "apellidos" => "Cuerpo Perez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741397?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741397/v1_201304251925/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480609741373" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74137-3" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74137" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:242-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1578 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 860 "PDF" => 708 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Avances sobre la influencia del tejido adiposo en el adenocarcinoma de próstata" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "242" "paginaFinal" => "248" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Advances on the influence of adipose tissue on prostate cancer" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Constanza López Fontana, M. Eugenia Maselli Artola, M. Cristina Vanrell Rodríguez, Nicolás A. Di Milta Mónaco, Rafael Pérez Elizalde, José D. López Laur" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Constanza" "apellidos" => "López Fontana" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Eugenia Maselli Artola" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Cristina Vanrell Rodríguez" ] 3 => array:2 [ "nombre" => "Nicolás A." "apellidos" => "Di Milta Mónaco" ] 4 => array:2 [ "nombre" => "Rafael" "apellidos" => "Pérez Elizalde" ] 5 => array:2 [ "nombre" => "José D." "apellidos" => "López Laur" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741373?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741373/v1_201304251925/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Factores pronósticos en la supervivencia de los pacientes con carcinoma transicional de vejiga tratados con cistectomía radical" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "249" "paginaFinal" => "257" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juan I. Monzó Gardiner, Felipe Herranz Amo, José M. Díez Cordero, Ramiro Cabello Benavente, Ángel Silmi Moyano, Carlos Hernández Fernández" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Juan I." "apellidos" => "Monzó Gardiner" "email" => array:1 [ 0 => "juanimonzo@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Felipe" "apellidos" => "Herranz Amo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "José M." "apellidos" => "Díez Cordero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Ramiro" "apellidos" => "Cabello Benavente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Ángel" "apellidos" => "Silmi Moyano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Carlos" "apellidos" => "Hernández Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital General Universitario Gregorio Marañón. Hospital Clínico San Carlos. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Hospital Clínico San Carlos. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. Juan I. Monzó Garnier Servicio Urología. Fundación Jiménez Díaz Avda. Reyes Católicos 2 - 28040 Madrid. Tel.: 915 504 800" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prognostic factors for survival in patients with transitional baldder cancer treated with radical cystectomy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-01" "fechaAceptado" => "2008-12-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras claves" "identificador" => "xpalclavsec88904" "palabras" => array:3 [ 0 => "Cáncer de vejiga" 1 => "Cistectomía radical" 2 => "Supervivencia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88903" "palabras" => array:3 [ 0 => "Bladder cancer" 1 => "Radical cystectomy" 2 => "Survival" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">conocer las variables clínicas y patológicas que influyen en la mortalidad cáncer-específica de los pacientes con carcinoma transicional de vejiga tratados mediante cistectomía radical (CR).</p> <span class="elsevierStyleSectionTitle">Material y Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">análisis retrospectivo de 333 pacientes con cáncer transicional de vejiga tratados mediante CR. Se analizaron variables agrupadas en el período pre-cistectomía, peri-cistectomía y de seguimiento. Se definieron 4 grupos de riesgo en función del estadio patológico: a) Enfermedad localizada vesical sin afectación ganglionar (pT0-2, pN0); b) Enfermedad extravesical sin afectación ganglionar (pT3-4, pN0); c) Enfermedad con afectación ganglionar (pT0-4, pN+); d) Sin datos sobre la afectación ganglionar (pT0-4, pNx). Realizamos un análisis univariante y dos modelos de multivariante con y sin los grupos de riesgo descritos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La media de seguimiento de la serie fue de 52,6 ± 51 (2-221) meses con una mediana de 31 meses. Un 7,2% de los pacientes presentó estadio pT0, 12% pT1, 26,7% pT2, 34,5% pT3 y un 19,5% pT4. El 20,7% de los pacientes tenían metástasis ganglionares (pN+). La supervivencia cáncer específica a los 5 años fue del 57% y del 54% a los 10 años.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El estadio patológico, la afectación ganglionar y los grupos de riesgo se comportaron como factores predictivos independientes para la supervivencia cáncer-específica. La asociación por grupos de riesgo permite predecir de una forma más fiable el riesgo de fallecer por cáncer de vejiga e identificar a los pacientes en los que la cistectomía resulta un tratamiento insuficiente y que se podrían beneficiar de un tratamiento adyuvante.</p>" ] "en" => array:2 [ "titulo" => "Absctract" "resumen" => "<span class="elsevierStyleSectionTitle">Purpose</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">to recognize clinical and pathological variables that influence in bladder cancer specific mortality in patients with transitional bladder cancer treated with radical cystectomy.</p> <span class="elsevierStyleSectionTitle">Matherial and Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">retrospective analysis of 333 patients with transitional bladder cancer treated with radical cystectomy. Variables included during pre-cystectomy, peri-cystectomy and post-cystectomy period were analyzed. Four groups were defined based on pathological state: a) Organ-confine bladder cancer without lymph node metastasis (pT0-2, pN0); b) Extravesical desease without lymph node metastasis (pT3-4, pN0); c) Bladder cancer with lymph node metastasis (pT0-4, pN+); d) No data of lymph node affection (pT0-4, pNx). Univariate analysis and two models of multivariate analysis were performed including the risk group as a variable in one the latest.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Mean follow up was 52.6 ± 51 (2-221) months with a median of 31 months. Pathological state pT0 was observed in 7.2% of the patients, 12% were pT1, 26.7% pT2, 34.5% pT3 and 10.5% pT4. Lymph node metastasis was detected in 20.7% of the patients. Lymph node metastasis increased according to pathological state rises. Five and 10 years specific survival was 57% and 54% respectively.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Local pathological state, lymph node status and risk groups were independent predictive factors for bladder cancer specific survival. Risk group association is a reliable method to predict bladder cancer specific survival and to identify the suitable patient group to get benefit from adjuvant therapy.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Globocan 2002. International Agency for research on Cancer. Acceso Junio de 2007. 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