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array:24 [ "pii" => "S0210480609741105" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74110-5" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74110" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2009;33:113-26" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2767 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1247 "PDF" => 1512 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609741117" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74111-7" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74111" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2009;33:127-33" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2266 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1284 "PDF" => 975 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Cáncer de riñón hereditario" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "127" "paginaFinal" => "133" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hereditary renal cancer" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Julián Sanz-Ortega, Carlos Olivier, Pedro Pérez Segura, Isabel Galante Romo, Luis San José Mansó, Mamen Saez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Julián" "apellidos" => "Sanz-Ortega" ] 1 => array:2 [ "nombre" => "Carlos" "apellidos" => "Olivier" ] 2 => array:2 [ "nombre" => "Pedro" "apellidos" => "Pérez Segura" ] 3 => array:2 [ "nombre" => "Isabel" "apellidos" => "Galante Romo" ] 4 => array:2 [ "nombre" => "Luis" "apellidos" => "San José Mansó" ] 5 => array:2 [ "nombre" => "Mamen" "apellidos" => "Saez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741117?idApp=UINPBA00004N" "url" => "/02104806/0000003300000002/v1_201304251922/S0210480609741117/v1_201304251922/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480609741099" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74109-9" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74109" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Actas Urol Esp. 2009;33:112" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2503 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1537 "PDF" => 960 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Comentario editorial sobre Laparo-endoscopia por acceso único: experiencia inicial" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "112" ] ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio Alcaraz Asensio" "autores" => array:2 [ 0 => array:1 [ "colaborador" => "En referencia al trabajo de este número que aparece en las páginas 172-181" ] 1 => array:2 [ "nombre" => "Antonio" "apellidos" => "Alcaraz Asensio" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741099?idApp=UINPBA00004N" "url" => "/02104806/0000003300000002/v1_201304251922/S0210480609741099/v1_201304251922/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Guía de la eau para el cáncer de próstata<a class="elsevierStyleCrossRef" href="#fn0005">(*)</a>" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "113" "paginaFinal" => "126" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Axel Heidenreich, Gunna Aus, Michel Bolla, Steven Joniau, B. Matveev Vsevolod, Hans Peter Schmid, Filliberto Zattoni" "autores" => array:8 [ 0 => array:1 [ "colaborador" => "EAU Guidelines on Prostate Cancer" ] 1 => array:4 [ "nombre" => "Axel" "apellidos" => "Heidenreich" "email" => array:1 [ 0 => "axel.heidenreich@uk-koeln.de" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Gunna" "apellidos" => "Aus" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Michel" "apellidos" => "Bolla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Steven" "apellidos" => "Joniau" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "B." "apellidos" => "Matveev Vsevolod" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 6 => array:3 [ "nombre" => "Hans Peter" "apellidos" => "Schmid" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 7 => array:3 [ "nombre" => "Filliberto" "apellidos" => "Zattoni" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "aServicio de Urología, Hospital Universitario de Colonia, Colonia, Alemania." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología, Hospital Universitario de Sahlgrens, Göteborg, Suecia." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Radioterapia, C.H.U Grenoble, Grenoble, Francia." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Urología, Hospital Universitario de Gasthuisberg, Leuven, Bélgica." "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Urología, Academia Rusa de Ciencias Médicas, Centro de Investigaciones Oncológicas, Moscú, Rusia." "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Servicio de Urología, Kantonspital St. Gallen, St. Gallen, Suiza." "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Servicio de Urología, Hospital Santa Maria Della Misericordia, Udine, Italia." "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Autor para correspondencia: Dr. Axel Heidenreich Department of Urology, Division of Oncological Urology, University of Koln, Kerpener Strasse 62, 50924 Koln, Germany Tel.: +49 221 478 86577; Fax: +49 221 478 87901" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88834" "palabras" => array:10 [ 0 => "Bloqueo hormonal" 1 => "Quimioterapia" 2 => "Diagnostico" 3 => "Guias de la EAU" 4 => "Seguimiento" 5 => "Cancer de prostata" 6 => "Radioterapia" 7 => "Prostatectomia radical" 8 => "Revision" 9 => "Tratamiento" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88833" "palabras" => array:10 [ 0 => "Androgen deprivation" 1 => "Chemotherapy" 2 => "Diagnosis" 3 => "EAU guidelines" 4 => "Follow-up" 5 => "Prostate cancer" 6 => "Radiation therapy" 7 => "Radical prostatectomy" 8 => "Review" 9 => "Treatment" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Presentar un resumen de la version del 2007 de la guia de la Asociacion Europea de Urologia (EAU) para el cancer de prostata (CaP).</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realizo por un grupo de trabajo una revision de los nuevos datos presentes desde 2004 hasta 2007 en la literatura. Las guias han sido actualizadas y el nivel de evidencia/grado de recomendacion ha sido anadido al texto basandose en una revision sistematica de la literatura, que incluia una busqueda de las bases de datos online y revisiones bibliograficas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Una version completa esta disponible en la EAU Office o en <span class="elsevierStyleInterRef" href="http://www.uroweb.org">www.uroweb.org.</span> El metodo diagnostico de eleccion es la biopsia sistematizada de la prostata bajo control ecografico. El tratamiento activo es el recomendado en la mayoria de los pacientes con enfermedad localizada y una larga esperanza de vida, siendo la prostatectomia radical superior a la vigilancia (“watchful waiting”) en un ensayo randomizado prospectivo. La prostatectomia radical con preservacion de bandeletas es la tecnica de eleccion en la enfermedad organo-confinada; el bloqueo androgenico neoadyuvante no ha demostrado una mejoria en las variables de resultados. La radioterapia debe realizarse con al menos 72 Gy en el CaP de bajo riesgo y con 78 Gy en el de intermedio - alto riesgo. El bloqueo androgenico en monoterapia es el estandar del tratamiento en el CaP metastasico; el bloqueo androgenico intermitente podria ser un tratamiento alternativo en pacientes seleccionados. El seguimiento se basa principalmente en los niveles de PSA y en la anamnesis especifica de la enfermedad, estando las pruebas de imagen solo indicadas cuando aparecen los sintomas. La quimioterapia con docetaxel ha surgido como el tratamiento de referencia para el CaP metastasico hormonorefractario.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El conocimiento en el campo del CaP esta rapidamente cambiando. Estas guias de la EAU resumen los hallazgos mas recientes y los aplican a la practica clinica.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To present a summary of the 2007 version of the European Association of Urology (EAU) guidelines on prostate cancer (PCa).</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A literature review of the new data emerging from 2004 to 2007 was performed by the working panel. The guidelines have been updated, and the level of evidence/grade of recommendation was added to the text based on a systematic review of the literature, which included a search of online databases and bibliographic reviews.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Afull version is available at the EAU Office or at <span class="elsevierStyleInterRef" href="http://www.uroweb.org">www.uroweb.org.</span> Systemic prostate biopsy under ultrasound guidance is the preferred diagnostic method. Active treatment is mostly recommended for patients with localized disease and a long life expectancy, with radical prostatectomy being shown to be superior to watchful waiting in a prospective randomized trial. Nerve-sparing radical prostatectomy represents the approach of choice in organ-confined disease; neoadjuvant androgen deprivation demonstrates no improvement of outcome variables. Radiation therapy should be performed with at least 72 and 78 Gy in low-risk and intermediate- to high-risk PCa, respectively. Monotherapeutic androgen deprivation is the standard of care in metastatic PCa; intermittent androgen deprivation might be an alternative treatment option for selected patients. Follow-up is largely based on prostate-specific antigen and a disease-specific history with imaging only indicated when symptoms occur. Cytotoxic therapy with docetaxel has emerged as the reference treatment for metastatic hormone-refractory PCa.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The knowledge in the field of PCa is rapidly changing. These EAU guidelines on PCa summarize the most recent findings and put them into clinical practice.Keywords: Androgen deprivation. Chemotherapy. Diagnosis. EAU guidelines. Follow-up. Prostate cancer. Radiation therapy. Radical prostatectomy. Review. Treatment.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "(*)" "nota" => "<p class="elsevierStyleNotepara">La traducción de este artículo se ha llevado a cabo con el permiso de la Asociación Europea de Urología.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EAU guidelines on prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Aus" 1 => "C.C. Abbou" 2 => "M. Bolla" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Urol" "fecha" => "2005" "volumen" => "48" "paginaInicial" => "451" "paginaFinal" => "546" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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