metricas
covid
Buscar en
Annals of Hepatology
Toda la web
Inicio Annals of Hepatology 109 TREATMENT PROFILE OF AUTOIMMUNE HEPATITIS IN A BRAZILIAN TERTIARY HOSPITAL
Información de la revista
Vol. 24. Núm. S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(septiembre 2021)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 24. Núm. S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(septiembre 2021)
Open Access
109 TREATMENT PROFILE OF AUTOIMMUNE HEPATITIS IN A BRAZILIAN TERTIARY HOSPITAL
Visitas
508
Camila Toledo Turano1, Renata da Silva Moutinho1, Raul Carlos Wahle1, Luiza Alencar Saldanha Queiroz1, Claudia de Fatima Gomes Vieira Oliveira1, Ana Luisa Vieira Rodrigues De Queiroz1, Dora Gama Ribeiro LeiteAltikes1, Paula Bechara Poletti1
1 Gastroenterology Service of Hospital do Servidor Público Estadual “Francisco Morato de Oliveira”, HSPE-FMO, São Paulo, SP, Brazil
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Suplemento especial
Este artículo forma parte de:
Vol. 24. Núm S1

Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)

Más datos
Introduction

Autoimmune hepatitis (IAH) is a rare disease, marked by periods of inflammation and remission. It occurs in any age group with a bimodal incidence. The aim of IAH treatment is to achieve a complete normalization of the levels of aminotransferase and immunoglobulin and to remain remission after treatment withdrawal and to reduce the development of cirrhosis and its complications.

Objective

Our study evaluated the profile of treatment response IAH patients and identify variables related to biochemical and histological remission.

Methodology

Descriptive, retrospective and observational study, with analysis of data from the medical records of patients, from July 2002 to July 2020, with the inclusion of patients diagnosed with IAH and patients with intake of alcoholic beverages, infected with viral hepatitis, with drug-induced injury or who had overlap syndromes were excluded from the study.

Results

35 adults with IAH were included, the average age at the diagnosis was 54.7 ± 14.2 years. All received corticosteroids and azathioprine. Side effects were observed in 28% of cases. A biochemical remission was achieved in 85% of patients and to those who underwent a new liver biopsy after treatment withdrawal, we found 68% of histological remission. Relapsed rate observed after treatment withdrawal was 35% (5/14), all of them in the first year of follow up. High levels of serum albumin was a positive factor for biochemical remission otherwise high titers of anti-smooth muscle antibody showed a worse rate of histological remission.

Conclusion

The response of treatment were similar to observed in European and North-American studies and minimum side effects were reported. Finally, patients with antismooth muscle antibody positivity achieved a lower histological response and such patients should be considered optimization of standard treatment.

El Texto completo está disponible en PDF
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.aohep.2021.100467
No mostrar más